ID   5NTD_RAT       STANDARD;      PRT;   576 AA.
AC   P21588;
DT   01-MAY-1991 (REL. 18, CREATED)
DT   01-MAY-1991 (REL. 18, LAST SEQUENCE UPDATE)
DT   15-JUL-1998 (REL. 36, LAST ANNOTATION UPDATE)
DE   5'-NUCLEOTIDASE PRECURSOR (EC 3.1.3.5) (ECTO-NUCLEOTIDASE) (5'-NT)
DE   (CD73).
GN   NT5.
OS   RATTUS NORVEGICUS (RAT).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA;
OC   EUTHERIA; RODENTIA.
RN   [1]
RP   SEQUENCE FROM N.A., AND PARTIAL SEQUENCE.
RC   TISSUE=LIVER;
RX   MEDLINE; 90130472.
RA   MISUMI Y., OGATA S., HIROSE S., IKEHARA Y.;
RL   J. BIOL. CHEM. 265:2178-2183(1990).
RN   [2]
RP   SEQUENCE OF 538-551, AND GPI-ANCHOR.
RC   TISSUE=LIVER;
RX   MEDLINE; 91084455.
RA   OGATA S., HAYASHI Y., MISUMI Y., IKEHARA Y.;
RL   BIOCHEMISTRY 29:7923-7927(1990).
CC   -!- FUNCTION: HYDROLYZES EXTRACELLULAR NUCLEOTIDES INTO MEMBRANE
CC       PERMEABLE NUCLEOSIDES.
CC   -!- CATALYTIC ACTIVITY: A 5'-RIBONUCLEOTIDE + H(2)O = A
CC       RIBONUCLEOSIDE + ORTHOPHOSPHATE.
CC   -!- COFACTOR: ZINC.
CC   -!- SUBUNIT: HOMODIMER, LINKED BY DISULFIDE BOND(S).
CC   -!- SUBCELLULAR LOCATION: ATTACHED TO THE MEMBRANE BY A GPI-ANCHOR.
CC   -!- SIMILARITY: BELONGS TO THE 5'-NUCLEOTIDASE FAMILY.
DR   EMBL; J05214; G202551; -.
DR   PIR; A35036; A35036.
DR   PIR; A35613; A35613.
DR   PROSITE; PS00785; 5_NUCLEOTIDASE_1; 1.
DR   PROSITE; PS00786; 5_NUCLEOTIDASE_2; 1.
KW   HYDROLASE; SIGNAL; GPI-ANCHOR; GLYCOPROTEIN; ZINC.
FT   SIGNAL        1     28
FT   CHAIN        29    551       5'-NUCLEOTIDASE.
FT   PROPEP      552    576       REMOVED IN MATURE FORM.
FT   LIPID       551    551       GPI-ANCHOR.
FT   CARBOHYD     55     55       POTENTIAL.
FT   CARBOHYD    313    313       POTENTIAL.
FT   CARBOHYD    335    335       POTENTIAL.
FT   CARBOHYD    349    349       POTENTIAL.
FT   CARBOHYD    405    405       POTENTIAL.
SQ   SEQUENCE   576 AA;  63968 MW;  921590B3 CRC32;
     MRPAAATAPK WLLLALSALL PLWPTAKSWE LTIMHTNDVH SRLEQTSDDS TKCLNASLCV
     GGVARLFTKV QQIRKEEPNV LLLDAGDQYQ GTIWFTVYKG LEVAHFMNLL GYDAMALGNH
     EFDNGVEGLI DPLLRNVKFP ILSANIKARG PLAPQISGLY LPYKVLSVGG EVVGIVGYTS
     KETPFLSNPG TNLVFEDEVT ALQPEVDKLK TLNVNKIIAL GHSGFEMDKL IAQKVRGVDV
     VVGGHTNTFL YTGNPPSKEV PAGKYPFIVT SDDGRKVPVV QAYAFGKYLG YLKVEFDDKG
     NVVTSYGNPI LLNSTIREDA AIKADINQWR IKLDNYSTQE LGRTIVYLNG SAQECRFREC
     NMGNLICDAM INNNLRHPDE MFWNHVSMCI VNGGGIRSPI DERNNGTITW ENLAAVLPFG
     GTFDLVQLKG STLKKAFEHS VHRYGQSTGE FLQVGGIHVV YDISRKPWDR VVQLKVLCTK
     CRVPIYEPLE MDKVYKVVLP SYLVNGGDGF QMIKDELLKH DSGDQDISVV SEYISKMKVI
     YPAVEGRIKF SAASHYQGSF PLIILSFWAV ILVLYQ
//