ID 5NTD_HUMAN STANDARD; PRT; 574 AA. AC P21589; DT 01-MAY-1991 (REL. 18, CREATED) DT 01-MAY-1991 (REL. 18, LAST SEQUENCE UPDATE) DT 01-NOV-1997 (REL. 35, LAST ANNOTATION UPDATE) DE 5'-NUCLEOTIDASE PRECURSOR (EC 3.1.3.5) (ECTO-NUCLEOTIDASE) (5'-NT) DE (CD73 ANTIGEN). GN NT5 OR NTE. OS HOMO SAPIENS (HUMAN). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; PRIMATES. RN [1] RP SEQUENCE FROM N.A., AND PARTIAL SEQUENCE. RC TISSUE=PLACENTA; RX MEDLINE; 90361037. RA MISUMI Y., OGATA S., OHKUBO K., HIROSE S., IKEHARA Y.; RL EUR. J. BIOCHEM. 191:563-569(1990). RN [2] RP SEQUENCE OF 27-40. RC TISSUE=PLACENTA; RX MEDLINE; 91058583. RA KLEMENS M.R., SHERMAN W.R., HOLMBERG N.J., RUEDI J.M., LOW M.G., RA THOMPSON L.F.; RL BIOCHEM. BIOPHYS. RES. COMMUN. 172:1371-1377(1990). CC -!- FUNCTION: HYDROLYZES EXTRACELLULAR NUCLEOTIDES INTO MEMBRANE CC PERMEABLE NUCLEOSIDES. CC -!- CATALYTIC ACTIVITY: A 5'-RIBONUCLEOTIDE + H(2)O = A CC RIBONUCLEOSIDE + ORTHOPHOSPHATE. CC -!- COFACTOR: ZINC. CC -!- SUBUNIT: HOMODIMER, LINKED BY DISULFIDE BOND(S). CC -!- SUBCELLULAR LOCATION: ATTACHED TO THE MEMBRANE BY A GPI-ANCHOR. CC -!- SIMILARITY: BELONGS TO THE 5'-NUCLEOTIDASE FAMILY. CC -!- DATABASE: NAME=PROW; NOTE=CD guide CD73 entry; CC WWW="http://www.ncbi.nlm.nih.gov/prow/cd/cd73.htm". DR EMBL; X55740; G23897; -. DR PIR; S11032; S11032. DR MIM; 129190; -. DR PROSITE; PS00785; 5_NUCLEOTIDASE_1; 1. DR PROSITE; PS00786; 5_NUCLEOTIDASE_2; 1. KW HYDROLASE; SIGNAL; GPI-ANCHOR; GLYCOPROTEIN; ZINC. FT SIGNAL 1 26 FT CHAIN 27 549 5'-NUCLEOTIDASE. FT PROPEP 550 574 REMOVED IN MATURE FORM. FT LIPID 549 549 GPI-ANCHOR. FT CARBOHYD 53 53 POTENTIAL. FT CARBOHYD 311 311 POTENTIAL. FT CARBOHYD 333 333 POTENTIAL. FT CARBOHYD 403 403 POTENTIAL. SQ SEQUENCE 574 AA; 63367 MW; F3401352 CRC32; MCPRAARAPA TLLLALGAVL WPAAGAWELT ILHTNDVHSR LEQTSEDSSK CVNASRCMGG VARLFTKVQQ IRRAEPNVLL LDAGDQYQGT IWFTVYKGAE VAHFMNALRY DAMALGNHEF DNGVEGLIEP LLKEAKFPIL SANIKAKGPL ASQISGLYLP YKVLPVGDEV VGIVGYTSKE TPFLSNPGTN LVFEDEITAL QPEVDKLKTL NVNKIIALGH SGFEMDKLIA QKVRGVDVVV GGHSNTFLYT GNPPSKEVPA GKYPFIVTSD DGRKVPVVQA YAFGKYLGYL KIEFDERGNV ISSHGNPILL NSSIPEDPSI KADINKWRIK LDNYSTQELG KTIVYLDGSS QSCRFRECNM GNLICDAMIN NNLRHTDEMF WNHVSMCILN GGGIRSPIDE RNNGTITWEN LAAVLPFGGT FDLVQLKGST LKKAFEHSVH RYGQSTGEFL QVGGIHVVYD LSRKPGDRVV KLDVLCTKCR VPSYDPLKMD EVYKVILPNF LANGGDGFQM IKDELLRHDS GDQDINVVST YISKMKVIYP AVEGRIKFST GSHCHGSFSL IFLSLWAVIF VLYQ //