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GPI Anchor Biosynthesis Report: SMP3_YEAST (SMP3 family, Saccharomyces cerevisiae)




BLASTP 2.1.1 [Aug-8-2000]

Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query=
         (516 letters)

Database: nr
           887,402 sequences; 277,845,442 total letters

Searching..................................................

Converged !!!


Results of PSI-Blast iteration 4

Distribution of 52 Blast Hits on the Query Sequence


Sequences with E-value BETTER than threshold (0.002)

ref|NP_014792.1| (NC_001147) Involved in glycosyl phosphatidyl i... 594 e-168
emb|CAA41123.1| (X58121) SMP3 protein [Saccharomyces cerevisiae] 592 e-168
ref|NP_568305.1| (NM_121489) dolichyl-phosphate-mannose--glycoli... 386 e-106
gb|AAH17711.1|AAH17711 (BC017711) phosphatidylinositol glycan, c... 375 e-102
ref|NP_061377.1| (NM_018889) phosphatidylinositol glycan, class ... 374 e-102
ref|NP_004846.1| (NM_004855) phosphatidylinositol glycan, class ... 373 e-102
pir||T51430 dolichyl-phosphate-mannose--glycolipid alpha-mannosy... 350 2e-95
emb|CAB66861.1| (AL136927) hypothetical protein [Homo sapiens] 318 2e-85
gb|AAL25798.1| (AF395532) DIBD1 [Homo sapiens] 316 6e-85
gb|AAH21791.1|AAH21791 (BC021791) Similar to disrupted in bipola... 315 1e-84
dbj|BAB32949.1| (AP002908) putative glycolipid alpha-mannosyltra... 314 2e-84
gb|AAH09255.1|AAH09255 (BC009255) hypothetical protein FLJ21845 ... 314 3e-84
ref|NP_079016.1| (NM_024740) disrupted in bipolar disorder 1; si... 312 1e-83
gb|AAF47795.1| (AE003479) CG12006 gene product [Drosophila melan... 311 3e-83
sp|Q09837|YADC_SCHPO HYPOTHETICAL 62.2 KD PROTEIN C4G8.12C IN CH... 299 1e-79
pir||T41079 probable alpha 1,2 mannosyltransferase - fission yea... 293 3e-78
ref|NP_079439.1| (NM_025163) hypothetical protein FLJ12768 [Homo... 278 2e-73
emb|CAD22101.1| (AJ429133) putative mannosyltransferase [Mus mus... 269 6e-71
gb|AAF54441.1| (AE003684) CG8412 gene product [Drosophila melano... 267 3e-70
dbj|BAA94863.1| (AB033824) GPI anchor biosynthesis protein [Tryp... 266 7e-70
ref|XP_081472.1| (XM_081472) CG11851 [Drosophila melanogaster] >... 265 1e-69
pir||T50116 probable mannosyltransferase involved in N-glycosyla... 264 3e-69
ref|NP_077010.1| (NM_024105) hypothetical protein MGC3136 [Homo ... 253 7e-66
emb|CAC83681.1| (AJ290427) putative dolichyl-p-man: Man7GlcNAc2-... 252 1e-65
ref|NP_011373.1| (NC_001139) Involved in glycosyl phosphatidyl i... 244 3e-63
ref|NP_173134.1| (NM_101551) Ser/Thr protein kinase, putative [A... 244 3e-63
ref|NP_505071.1| (NM_072670) ZC513.5.p [Caenorhabditis elegans] ... 241 2e-62
ref|NP_014180.1| (NC_001146) catalyzes the transfer of mannose f... 233 5e-60
gb|AAF99843.1|AC051629_10 (AC051629) Hypothetical protein [Arabi... 230 5e-59
pir||T28996 hypothetical protein ZC513.5 - Caenorhabditis elegans 229 7e-59
gb|AAF47201.1| (AE003464) CG3419 gene product [Drosophila melano... 229 8e-59
ref|NP_496282.1| (NM_063881) C14A4.3.p [Caenorhabditis elegans] ... 229 1e-58
pir||T39659 cell wall biosynthesis protein N3265 homolog - fissi... 214 3e-54
ref|NP_014427.1| (NC_001146) ExtraCellular Mutant; Ecm39p [Sacch... 202 1e-50
ref|XP_016392.3| (XM_016392) hypothetical protein FLJ12768 [Homo... 201 3e-50
gb|AAD53921.1|AF179611_5 (AF179611) phosphatidylinositol glycan ... 201 3e-50
emb|CAC02000.2| (AL390114) possible hypothetical 66.3 Kd protein... 173 4e-42
dbj|BAB21931.1| (AB055306) hypothetical protein [Macaca fascicul... 148 3e-34
gb|AAH21379.1|AAH21379 (BC021379) Similar to hypothetical protei... 134 3e-30
dbj|BAA87150.1| (AB027846) Hypothetical protein [Schizosaccharom... 130 5e-29
pir||T16945 hypothetical protein T27F7.3 - Caenorhabditis elegans 128 3e-28
emb|CAA42931.1| (X60381) ORF2 [Saccharomyces cerevisiae] 123 7e-27
ref|NP_494918.1| (NM_062517) T27F7.3a.p [Caenorhabditis elegans]... 121 2e-26
Sequences with E-value WORSE than threshold

ref|NP_440407.1| (NC_000911) unknown protein [Synechocystis sp. ... 45 0.004
ref|NP_069450.1| (NC_000917) conserved hypothetical protein [Arc... 35 4.3
Alignments
>ref|NP_014792.1| (NC_001147) Involved in glycosyl phosphatidyl inositol synthesis;
           most likely an alpha 1,2 mannosyltransferase utilized
           for addition of the fourth, side-branching mannose onto
           the GPI core structure.; Smp3p [Saccharomyces
           cerevisiae]
 sp|Q04174|SMP3_YEAST SMP3 PROTEIN
 pir||S67037 SMP3 protein - yeast (Saccharomyces cerevisiae)
 gb|AAC49635.1| (U55020) Smp3p [Saccharomyces cerevisiae]
 emb|CAA99355.1| (Z75057) ORF YOR149c [Saccharomyces cerevisiae]
          Length = 516

 Score =  594 bits (1517), Expect = e-168
 Identities = 516/516 (100%), Positives = 516/516 (100%)

Query: 1   MMRYQWWLYLVYAIGLMLCLGPSYIHPDEHFQCIEILAMQFMKVKGTIPWEFKSKFAARS 60
           MMRYQWWLYLVYAIGLMLCLGPSYIHPDEHFQCIEILAMQFMKVKGTIPWEFKSKFAARS
Sbjct: 1   MMRYQWWLYLVYAIGLMLCLGPSYIHPDEHFQCIEILAMQFMKVKGTIPWEFKSKFAARS 60

Query: 61  YGPLLLVYGPLFTILESFPEIQDNPALILYSMRLQNYVMYLLCYHFLIPKLIRDERKAVQ 120
           YGPLLLVYGPLFTILESFPEIQDNPALILYSMRLQNYVMYLLCYHFLIPKLIRDERKAVQ
Sbjct: 61  YGPLLLVYGPLFTILESFPEIQDNPALILYSMRLQNYVMYLLCYHFLIPKLIRDERKAVQ 120

Query: 121 FMQKSLLLTSYVTWTYQTHTFSNSIETLALISTLTVMEDMVNEKNIQRSNFKNSVILGLI 180
           FMQKSLLLTSYVTWTYQTHTFSNSIETLALISTLTVMEDMVNEKNIQRSNFKNSVILGLI
Sbjct: 121 FMQKSLLLTSYVTWTYQTHTFSNSIETLALISTLTVMEDMVNEKNIQRSNFKNSVILGLI 180

Query: 181 FSFGVFNRVTFPAFIFLPCLILFWKFYRVHWKSFSLLLLSFSFSSCLFVLIDTNIYNNGK 240
           FSFGVFNRVTFPAFIFLPCLILFWKFYRVHWKSFSLLLLSFSFSSCLFVLIDTNIYNNGK
Sbjct: 181 FSFGVFNRVTFPAFIFLPCLILFWKFYRVHWKSFSLLLLSFSFSSCLFVLIDTNIYNNGK 240

Query: 241 GFVITPLNNLKYNLNVQNLQVHGLHPRYTHLLVNLPQIVGPVLLLAIFSGYKLDKLSTYA 300
           GFVITPLNNLKYNLNVQNLQVHGLHPRYTHLLVNLPQIVGPVLLLAIFSGYKLDKLSTYA
Sbjct: 241 GFVITPLNNLKYNLNVQNLQVHGLHPRYTHLLVNLPQIVGPVLLLAIFSGYKLDKLSTYA 300

Query: 301 IISGLLFLSFFQHQELRFLVPLVPLLVTNLNWTPLSSTLVNKKIFKGTWLLFNIIMAFIM 360
           IISGLLFLSFFQHQELRFLVPLVPLLVTNLNWTPLSSTLVNKKIFKGTWLLFNIIMAFIM
Sbjct: 301 IISGLLFLSFFQHQELRFLVPLVPLLVTNLNWTPLSSTLVNKKIFKGTWLLFNIIMAFIM 360

Query: 361 GISHQAGIIQFLGDYFHFRTEQMGVHIWWKTYSPPTWMYMSNNLTVSSLINTQDGIESID 420
           GISHQAGIIQFLGDYFHFRTEQMGVHIWWKTYSPPTWMYMSNNLTVSSLINTQDGIESID
Sbjct: 361 GISHQAGIIQFLGDYFHFRTEQMGVHIWWKTYSPPTWMYMSNNLTVSSLINTQDGIESID 420

Query: 421 EVAFSVGNHHVIDLKGCDLPLLTETIRRLRLNGSITPLTLVTPNSMTSELKKLKRDGTIN 480
           EVAFSVGNHHVIDLKGCDLPLLTETIRRLRLNGSITPLTLVTPNSMTSELKKLKRDGTIN
Sbjct: 421 EVAFSVGNHHVIDLKGCDLPLLTETIRRLRLNGSITPLTLVTPNSMTSELKKLKRDGTIN 480

Query: 481 LIPKRNYLFHLDLDHLDFNDFTTFKPGLTVYSIELL 516
           LIPKRNYLFHLDLDHLDFNDFTTFKPGLTVYSIELL
Sbjct: 481 LIPKRNYLFHLDLDHLDFNDFTTFKPGLTVYSIELL 516
>emb|CAA41123.1| (X58121) SMP3 protein [Saccharomyces cerevisiae]
          Length = 516

 Score =  592 bits (1512), Expect = e-168
 Identities = 511/516 (99%), Positives = 514/516 (99%)

Query: 1   MMRYQWWLYLVYAIGLMLCLGPSYIHPDEHFQCIEILAMQFMKVKGTIPWEFKSKFAARS 60
           MMRYQWWLYLVYAIGLMLCLGPSYIHPDEHFQCIEILAMQFMKVKGTIPWEFKSKFAARS
Sbjct: 1   MMRYQWWLYLVYAIGLMLCLGPSYIHPDEHFQCIEILAMQFMKVKGTIPWEFKSKFAARS 60

Query: 61  YGPLLLVYGPLFTILESFPEIQDNPALILYSMRLQNYVMYLLCYHFLIPKLIRDERKAVQ 120
           YGPLLLVYGPLFTILESFPEIQDNPALILYSMRLQNYVMYLLCYHFLIPKLIRDERKAVQ
Sbjct: 61  YGPLLLVYGPLFTILESFPEIQDNPALILYSMRLQNYVMYLLCYHFLIPKLIRDERKAVQ 120

Query: 121 FMQKSLLLTSYVTWTYQTHTFSNSIETLALISTLTVMEDMVNEKNIQRSNFKNSVILGLI 180
           F++KSLLLTSYVTWTYQTHTFSNSIETLALISTLTVMEDMVN KNIQR NFKNSVILGLI
Sbjct: 121 FIKKSLLLTSYVTWTYQTHTFSNSIETLALISTLTVMEDMVNGKNIQRRNFKNSVILGLI 180

Query: 181 FSFGVFNRVTFPAFIFLPCLILFWKFYRVHWKSFSLLLLSFSFSSCLFVLIDTNIYNNGK 240
           FSFGVFNRVTFPAFIFLPCLILFWKFYRVHWKSFSLLLLSFSFSSCLFVLIDTNIYNNGK
Sbjct: 181 FSFGVFNRVTFPAFIFLPCLILFWKFYRVHWKSFSLLLLSFSFSSCLFVLIDTNIYNNGK 240

Query: 241 GFVITPLNNLKYNLNVQNLQVHGLHPRYTHLLVNLPQIVGPVLLLAIFSGYKLDKLSTYA 300
           GFVITPLNNLKYNLNVQNLQVHGLHPRYTHLLVNLPQI+GPVLLLAIFSGYKLDKLSTYA
Sbjct: 241 GFVITPLNNLKYNLNVQNLQVHGLHPRYTHLLVNLPQILGPVLLLAIFSGYKLDKLSTYA 300

Query: 301 IISGLLFLSFFQHQELRFLVPLVPLLVTNLNWTPLSSTLVNKKIFKGTWLLFNIIMAFIM 360
           IISGLLFLSFFQHQELRFLVPLVPLLVTNLNWTPLSSTLVNKKIFKGTWLLFNIIMAFIM
Sbjct: 301 IISGLLFLSFFQHQELRFLVPLVPLLVTNLNWTPLSSTLVNKKIFKGTWLLFNIIMAFIM 360

Query: 361 GISHQAGIIQFLGDYFHFRTEQMGVHIWWKTYSPPTWMYMSNNLTVSSLINTQDGIESID 420
           GISHQAGIIQFLGDYFHFRTEQMGVHIWWKTYSPPTWMYMSNNLTVSSLINTQDGIESID
Sbjct: 361 GISHQAGIIQFLGDYFHFRTEQMGVHIWWKTYSPPTWMYMSNNLTVSSLINTQDGIESID 420

Query: 421 EVAFSVGNHHVIDLKGCDLPLLTETIRRLRLNGSITPLTLVTPNSMTSELKKLKRDGTIN 480
           EVAFSVGNHHVIDLKGCDLPLLTETIRRLRLNGSITPLTLVTPNSMTSELKKLKRDGTIN
Sbjct: 421 EVAFSVGNHHVIDLKGCDLPLLTETIRRLRLNGSITPLTLVTPNSMTSELKKLKRDGTIN 480

Query: 481 LIPKRNYLFHLDLDHLDFNDFTTFKPGLTVYSIELL 516
           LIPKRNYLFHLDLDHLDFNDFTTFKPGLTVYSIELL
Sbjct: 481 LIPKRNYLFHLDLDHLDFNDFTTFKPGLTVYSIELL 516
>ref|NP_568305.1| (NM_121489) dolichyl-phosphate-mannose--glycolipid
           alpha-mannosyltransferase -like protein [Arabidopsis
           thaliana]
 gb|AAK91470.1| (AY050456) AT5g14850/T9L3_150 [Arabidopsis thaliana]
          Length = 548

 Score =  386 bits (983), Expect = e-106
 Identities = 87/437 (19%), Positives = 161/437 (35%), Gaps = 48/437 (10%)

Query: 5   QWWLYLVYAIGLMLCLGPS-YIHPDEHFQCIEILAMQFMKVKGTIPWEFKSKFAARSYGP 63
           +       A  ++  L    Y +PDEH+Q +E+ A + +   G + WE+  K   RSY  
Sbjct: 39  RRIFLFCLAFRVVNALLIQTYFNPDEHWQSLEV-AHRTIFGYGYMTWEW--KRGIRSYLH 95

Query: 64  LLLVYGPLFTILESFPEIQDNPALILYSMRLQNYVMYLLCYHFLIPKLIRDERKAVQFMQ 123
            +L +  L+ +L+      D P +++ + RL   +   +   +L           V    
Sbjct: 96  PML-FAFLYKLLQVTGL--DTPYIMIKAPRLMQSIFSAIGDLYLYKLSDALYGGNVATWS 152

Query: 124 KSLLLTSYVTWTYQTHTFSNSIETLALISTLTVMEDMVNEKNIQRSNFKNSV--ILGL-I 180
               + ++  +     TFSN +ET+  I  L           I+ S+    V    GL I
Sbjct: 153 LFCQMANWFIFFCLNRTFSNCLETVLTIMGLYY------WPCIRDSSIDYPVNRKWGLVI 206

Query: 181 FSFGVFNRVT-FPAFIFLPCLILFWKFYRVHWKSFSLLLLSFSFSSCLFVLIDTNIYNNG 239
            +     R T    ++++  L LF    +V +    ++ +  S       L+D  +Y + 
Sbjct: 207 AALACAIRPTSAVIWLYVGMLELFLTPNKVKFIILEVIPIG-SLVLGFTCLLDRLMYGS- 264

Query: 240 KGFVITPLNNLKYNLNVQNLQVHGLHPRYTHLLVNLPQIVGPVLLLAIFSGYKLDKL-ST 298
             +VI PLN LK+N        +G HP + +       ++      +I    K      +
Sbjct: 265 --WVIVPLNFLKFNFLSSGGDYYGTHPWHWYFTQGFLVMLFTFTPFSIAGIIKSKNQKLS 322

Query: 299 YAIISGLLFLSFFQHQELRFLVPLVPLLVTNLNWTPL----------------------S 336
             I+  L   S   H+E RF++P++P+ +    +                         +
Sbjct: 323 ALILWVLAIYSILGHKEFRFVLPVLPIALIFSGYAFAQMEVSGSSSSSSVTKKKQVPRQN 382

Query: 337 STLVNKKIFKGTWLL--FNIIMAFIMGISHQAGIIQFLGDYFHFR--TEQMGVHIWWKTY 392
            T  + K+    + L   NI MA  M + HQ G    +              +      +
Sbjct: 383 HTKWSPKLRLSVYFLLATNIPMALYMSLFHQRGTEDAMNYLSDEAYKGRVKSILFLMPCH 442

Query: 393 SPPTWMYMSNNLTVSSL 409
           S P +  +  N+ +  L
Sbjct: 443 STPYYSTLHRNIPMQFL 459
>gb|AAH17711.1|AAH17711 (BC017711) phosphatidylinositol glycan, class B [Homo sapiens]
          Length = 554

 Score =  375 bits (954), Expect = e-102
 Identities = 87/418 (20%), Positives = 165/418 (38%), Gaps = 34/418 (8%)

Query: 5   QWWLYLVYAIGLMLCLGPSY-IHPDEHFQCIEILAMQFMKVKGTIPWEFKSKFAARSYGP 63
            + L    A+ ++ C        PDE++Q +E+     +   G + WE+  +   RSY  
Sbjct: 61  IYLLLFTLALRILNCFLVQTSFVPDEYWQSLEVS-HHMVFNYGYLTWEWTERL--RSYTY 117

Query: 64  LLLVYGPLFTILESFPEIQDNPALILYSMRLQNYVMYLLCYHFLIPKLIRDERKAVQFMQ 123
             L++  ++ IL      +D+  L+++  RL   ++  +    L   + + E + V    
Sbjct: 118 P-LIFASIYKILHLLG--KDSVQLLIWIPRLAQALLSAVADVRLYSLMKQLENQEVARWV 174

Query: 124 KSLLLTSYVTWTYQTHTFSNSIETLALISTLTVMEDMVNEKNIQRSNFKNSVILGLIFSF 183
               L S+ TW   T T +N++ET+  I  L           ++ S   NSV    + + 
Sbjct: 175 FFCQLCSWFTWYCCTRTLTNTMETVLTIIALFYY-------PLEGSKSMNSVKYSSLVAL 227

Query: 184 GVFNRVTFPAFIFLPCLILFWKF----YRVHWKSFSLLLLSFSFSSCLFVLIDTNIYNNG 239
               R T      L   +LF  F     ++       L + F  +  L ++ID   +   
Sbjct: 228 AFIIRPTAV---ILWTPLLFRHFCQEPRKLDLILHHFLPVGFV-TLSLSLMIDRIFF--- 280

Query: 240 KGFVITPLNNLKYNLNVQNLQVHGLHPRYTHLLVNLPQIVG---PVLLLAIFSGYKLDKL 296
             + +   N LK+N+       +G HP + +     P I+G   P  +   +   K  ++
Sbjct: 281 GQWTLVQFNFLKFNVLQNLGTFYGSHPWHWYFSQGFPVILGTHLPFFIHGCYLAPKRYRI 340

Query: 297 STYAIISGLLFLSFFQHQELRFLVPLVPLLVTNLNWTPLSSTLVNKKIFKGTWLLFNIIM 356
               ++  LL  S   H+E RF+ P++P  +    ++ L+     KK       L N+ +
Sbjct: 341 LLVTVLWTLLVYSMLSHKEFRFIYPVLPFCMVFCGYS-LTHLKTWKKPALSFLFLSNLFL 399

Query: 357 AFIMGISHQAGIIQFLGD-----YFHFRTEQMGVHIWWKTYSPPTWMYMSNNLTVSSL 409
           A   G+ HQ G +  +       Y +       + I    +S P + ++   L +  L
Sbjct: 400 ALYTGLVHQRGTLDVMSHIQKVCYNNPNKSSASIFIMMPCHSTPYYSHVHCPLPMRFL 457
>ref|NP_061377.1| (NM_018889) phosphatidylinositol glycan, class B; involved in
           GPI-anchor biosynthesis [Mus musculus]
 dbj|BAA94827.1| (D84436) Pig-b [Mus musculus]
          Length = 542

 Score =  374 bits (952), Expect = e-102
 Identities = 84/417 (20%), Positives = 164/417 (39%), Gaps = 34/417 (8%)

Query: 6   WWLYLVYAIGLMLCLGPSY-IHPDEHFQCIEILAMQFMKVKGTIPWEFKSKFAARSYGPL 64
           + +    A+ ++ C        PDE++Q +E+ A + +   G + WE+  +    +Y   
Sbjct: 51  YLVLFTIALRILNCFLVQTSFVPDEYWQSLEV-AHRMVFSYGYLTWEWTERLRGYTYP-- 107

Query: 65  LLVYGPLFTILESFPEIQDNPALILYSMRLQNYVMYLLCYHFLIPKLIRDERKAVQFMQK 124
            L++  ++ +L      +D+   +++  RL   ++  +    L   L + E + V     
Sbjct: 108 -LIFASIYKVLHLLG--KDSVQFLIWIPRLGQALLSAVADIRLYSLLKQLENQEVAQWVF 164

Query: 125 SLLLTSYVTWTYQTHTFSNSIETLALISTLTVMEDMVNEKNIQRSNFKNSVILGLIFSFG 184
              L S+ TW   T T +N++ET      L           ++ S   NS+   L+ +  
Sbjct: 165 LCQLCSWFTWYCCTRTLTNTMETSLTALALFYY-------PLEGSRSVNSIKYSLLVALA 217

Query: 185 VFNRVTFPAFIFLPCLILFWKF----YRVHWKSFSLLLLSFSFSSCLFVLIDTNIYNNGK 240
              R T          +LF  F     ++H      L + F  +  L ++ID   +    
Sbjct: 218 CVVRPTAL---IPWVPLLFRHFYQEQRKLHLTLHHFLPVGF-ITFSLSLIIDRIFF---G 270

Query: 241 GFVITPLNNLKYNLNVQNLQVHGLHPRYTHLLVNLPQIVG---PVLLLAIFSGYKLDKLS 297
            + +  LN LK+N+       +G HP + +L    P ++G   P  +   F   +   + 
Sbjct: 271 QWTLVQLNFLKFNVLQNLGTFYGSHPWHWYLSQGFPVVLGTHLPFFIHGCFLAPRRLHIL 330

Query: 298 TYAIISGLLFLSFFQHQELRFLVPLVPLLVTNLNWTPLSSTLVNKKIFKGTWLLFNIIMA 357
              ++  LL  S   H+E RF+ P++P  +    ++        +K      LL N+ +A
Sbjct: 331 LLTVLWTLLVYSMLGHKEFRFIYPVLPFCMVFCGYSLA-HLKTWRKAALSFLLLSNVPLA 389

Query: 358 FIMGISHQAGIIQFLGDY-----FHFRTEQMGVHIWWKTYSPPTWMYMSNNLTVSSL 409
           F  G+ HQ G +  +                 V I    +S P + ++   L++  L
Sbjct: 390 FYTGLVHQRGTLDVMNHIQKVCPRGPDPASASVFIMMPCHSTPYYSHVHCPLSMRFL 446
>ref|NP_004846.1| (NM_004855) phosphatidylinositol glycan, class B [Homo sapiens]
 pir||S71751 dolichyl-phosphate-mannose--glycolipid alpha-mannosyltransferase
           (EC 2.4.1.130) PIGB - human
 dbj|BAA07709.1| (D42138) PIG-B [Homo sapiens]
          Length = 554

 Score =  373 bits (949), Expect = e-102
 Identities = 87/418 (20%), Positives = 165/418 (38%), Gaps = 34/418 (8%)

Query: 5   QWWLYLVYAIGLMLCLGPSY-IHPDEHFQCIEILAMQFMKVKGTIPWEFKSKFAARSYGP 63
            + L    A+ ++ C        PDE++Q +E+     +   G + WE+  +   RSY  
Sbjct: 61  IYLLLFTIALRILNCFLVQTSFVPDEYWQSLEVS-HHMVFNYGYLTWEWTERL--RSYTY 117

Query: 64  LLLVYGPLFTILESFPEIQDNPALILYSMRLQNYVMYLLCYHFLIPKLIRDERKAVQFMQ 123
             L++  ++ IL      +D+  L+++  RL   ++  +    L   + + E + V    
Sbjct: 118 P-LIFASIYKILHLLG--KDSVQLLIWIPRLAQALLSAVADVRLYSLMKQLENQEVARWV 174

Query: 124 KSLLLTSYVTWTYQTHTFSNSIETLALISTLTVMEDMVNEKNIQRSNFKNSVILGLIFSF 183
               L S+ TW   T T +N++ET+  I  L           ++ S   NSV    + + 
Sbjct: 175 FFCQLCSWFTWYCCTRTLTNTMETVLTIIALFYY-------PLEGSKSMNSVKYSSLVAL 227

Query: 184 GVFNRVTFPAFIFLPCLILFWKF----YRVHWKSFSLLLLSFSFSSCLFVLIDTNIYNNG 239
               R T      L   +LF  F     ++       L + F  +  L ++ID   +   
Sbjct: 228 AFIIRPTAV---ILWTPLLFRHFCQEPRKLDLILHHFLPVGFV-TLSLSLMIDRIFF--- 280

Query: 240 KGFVITPLNNLKYNLNVQNLQVHGLHPRYTHLLVNLPQIVG---PVLLLAIFSGYKLDKL 296
             + +   N LK+N+       +G HP + +     P I+G   P  +   +   K  ++
Sbjct: 281 GQWTLVQFNFLKFNVLQNWGTFYGSHPWHWYFSQGFPVILGTHLPFFIHGCYLAPKRYRI 340

Query: 297 STYAIISGLLFLSFFQHQELRFLVPLVPLLVTNLNWTPLSSTLVNKKIFKGTWLLFNIIM 356
               ++  LL  S   H+E RF+ P++P  +    ++ L+     KK       L N+ +
Sbjct: 341 LLVTVLWTLLVYSMLSHKEFRFIYPVLPFCMVFCGYS-LTHLKTWKKPALSFLFLSNLFL 399

Query: 357 AFIMGISHQAGIIQFLGD-----YFHFRTEQMGVHIWWKTYSPPTWMYMSNNLTVSSL 409
           A   G+ HQ G +  +       Y +       + I    +S P + ++   L +  L
Sbjct: 400 ALYTGLVHQRGTLDVMSHIQKVCYNNPNKSSASIFIMMPCHSTPYYSHVHCPLPMRFL 457
>pir||T51430 dolichyl-phosphate-mannose--glycolipid
           alpha-mannosyltransferase-like protein - Arabidopsis
           thaliana
 emb|CAC01884.1| (AL391149) dolichyl-phosphate-mannose--glycolipid
           alpha-mannosyltransferase-like protein [Arabidopsis
           thaliana]
          Length = 498

 Score =  350 bits (891), Expect = 2e-95
 Identities = 80/437 (18%), Positives = 150/437 (34%), Gaps = 71/437 (16%)

Query: 5   QWWLYLVYAIGLMLCLGPS-YIHPDEHFQCIEILAMQFMKVKGTIPWEFKSKFAARSYGP 63
           +       A  ++  L    Y +PDEH+Q +E+ A + +   G + WE+  K   RSY  
Sbjct: 39  RRIFLFCLAFRVVNALLIQTYFNPDEHWQSLEV-AHRTIFGYGYMTWEW--KRGIRSYLH 95

Query: 64  LLLVYGPLFTILESFPEIQDNPALILYSMRLQNYVMYLLCYHFLIPKLIRDERKAVQFMQ 123
            +L +  L+ +L+      D P +++ + RL   +   +   +L           V    
Sbjct: 96  PML-FAFLYKLLQVTGL--DTPYIMIKAPRLMQSIFSAIGDLYLYKLSDALYGGNVATWS 152

Query: 124 KSLLLTSYVTWTYQTHTFSNSIETLALISTLTVMEDMVNEKNIQRSNFKNSV--ILGL-I 180
             L +                               +     I+ S+    V    GL I
Sbjct: 153 TVLTIM-----------------------------GLYYWPCIRDSSIDYPVNRKWGLVI 183

Query: 181 FSFGVFNRVT-FPAFIFLPCLILFWKFYRVHWKSFSLLLLSFSFSSCLFVLIDTNIYNNG 239
            +     R T    ++++  L LF    +V +    ++ +  S       L+D  +Y + 
Sbjct: 184 AALACAIRPTSAVIWLYVGMLELFLTPNKVKFIILEVIPIG-SLVLGFTCLLDRLMYGS- 241

Query: 240 KGFVITPLNNLKYNLNVQNLQVHGLHPRYTHLLVNLPQIVGPVLLLAIFSGYKLDKL-ST 298
             +VI PLN LK+N        +G HP + +       ++      +I    K      +
Sbjct: 242 --WVIVPLNFLKFNFLSSGGDYYGTHPWHWYFTQGFLVMLFTFTPFSIAGIIKSKNQKLS 299

Query: 299 YAIISGLLFLSFFQHQELRFLVPLVPLLVTNLNWTPL----------------------S 336
             I+  L   S   H+E RF++P++P+ +    +                         +
Sbjct: 300 ALILWVLAIYSILGHKEFRFVLPVLPIALIFSGYAFAQMEVSGSSSSSSVTKKKQVPRQN 359

Query: 337 STLVNKKIFKGTWLL--FNIIMAFIMGISHQAGIIQFLGDYFHFR--TEQMGVHIWWKTY 392
            T  + K+    + L   NI MA  M + HQ G    +              +      +
Sbjct: 360 HTKWSPKLRLSVYFLLATNIPMALYMSLFHQRGTEDAMNYLSDEAYKGRVKSILFLMPCH 419

Query: 393 SPPTWMYMSNNLTVSSL 409
           S P +  +  N+ +  L
Sbjct: 420 STPYYSTLHRNIPMQFL 436
>emb|CAB66861.1| (AL136927) hypothetical protein [Homo sapiens]
          Length = 611

 Score =  318 bits (807), Expect = 2e-85
 Identities = 77/420 (18%), Positives = 132/420 (31%), Gaps = 66/420 (15%)

Query: 8   LYLVYAIGLMLCLGPSYIHPDEHFQCIEILAMQFMKVKGTIPWEFKSKFAARSYGPLLLV 67
              + +  L   L  +    DE F   E      +  +G   WE+   +A RSY  LLL 
Sbjct: 62  FKCLLSARLCAALLSNISDCDETFNYWEP-THYLIYGEGFQTWEYSPAYAIRSYAYLLLH 120

Query: 68  YGPLFTILESFPEIQDNPALILYSMRLQNYVMYLLCYHFLIPKLIRDERKAVQFMQKSLL 127
             P          +Q N  L+ Y +R     +  +C  +    + +     V  M  + L
Sbjct: 121 AWPAAFHAR---ILQTNKILVFYFLRCLLAFVSCICELYFYKAVCKKFGLHVSRMMLAFL 177

Query: 128 LTSYVTWTYQTHTFSNSIETLALISTLTVMEDMVNEKNIQRSNFKNSVILGLIFSFGVFN 187
           + S   +   +    +S      +        M      + S     V  G I  +    
Sbjct: 178 VLSTGMFCSSSAFLPSSFCMYTTLIA------MTGWYMDKTSIAVLGVAAGAILGWPFSA 231

Query: 188 RVTFPAFIFLPCLILFWKFYRVHWKSFSLLLLSFSFSSCLFVLIDTNIYNNGKGFVITPL 247
            +  P    L  +   WK +      F   L++        V+ID+  Y      VI PL
Sbjct: 232 ALGLPIAFDLLVMKHRWKSF------FHWSLMALILFLVPVVVIDSYYY---GKLVIAPL 282

Query: 248 NNLKYNLN-VQNLQVHGLHPRYTHLLVNLPQIVGPVLLLAIFSGY--------------- 291
           N + YN+       ++G  P Y +L +N          LA+                   
Sbjct: 283 NIVLYNVFTPHGPDLYGTEPWYFYL-INGFLNFNVAFALALLVLPLTSLMEYLLQRFHVQ 341

Query: 292 ---KLDKLSTYAIISGLLFLSFFQHQELRFLVPLVPLLVTNLNWTPLSSTL--------- 339
                  L+   +    +      H+E RFL P+ PL+        LS+           
Sbjct: 342 NLGHPYWLTLAPMYIWFIIFFIQPHKEERFLFPVYPLICL-CGAVALSALQKCYHFVFQR 400

Query: 340 --------VNKKIFKGTWLLFNII-----MAFIMGISHQAGIIQFLGDYFHFRTEQMGVH 386
                    +  +  GT  LF ++     +A   G     G +    +++   T+   +H
Sbjct: 401 YRLEHYTVTSNWLALGTVFLFGLLSFSRSVALFRGY---HGPLDLYPEFYRIATD-PTIH 456
>gb|AAL25798.1| (AF395532) DIBD1 [Homo sapiens]
          Length = 611

 Score =  316 bits (803), Expect = 6e-85
 Identities = 76/420 (18%), Positives = 131/420 (31%), Gaps = 66/420 (15%)

Query: 8   LYLVYAIGLMLCLGPSYIHPDEHFQCIEILAMQFMKVKGTIPWEFKSKFAARSYGPLLLV 67
              + +  L   L  +    DE F   E      +  +G   WE+   +A RSY  LLL 
Sbjct: 62  FKCLLSARLCAALLSNISDCDETFNYWEP-THYLIYGEGFQTWEYSPAYAIRSYAYLLLH 120

Query: 68  YGPLFTILESFPEIQDNPALILYSMRLQNYVMYLLCYHFLIPKLIRDERKAVQFMQKSLL 127
             P          +Q N  L+ Y +R     +  +C  +    + +     V  M  + L
Sbjct: 121 AWPAAFHAR---ILQTNKILVFYFLRCLLAFVSCICELYFYKAVCKKFGLHVSRMMLAFL 177

Query: 128 LTSYVTWTYQTHTFSNSIETLALISTLTVMEDMVNEKNIQRSNFKNSVILGLIFSFGVFN 187
           + S   +   +    +S      +        M      + S     V  G I  +    
Sbjct: 178 VLSTGMFCSSSAFLPSSFCMYTTLIA------MTGWYMDKTSIAVLGVAAGAILGWPFSA 231

Query: 188 RVTFPAFIFLPCLILFWKFYRVHWKSFSLLLLSFSFSSCLFVLIDTNIYNNGKGFVITPL 247
            +  P    L  +   WK +      F   L++        V+ID+  Y      VI PL
Sbjct: 232 ALGLPIAFDLLVMKHRWKSF------FHWSLMALILFLVPVVVIDSYYY---GKLVIAPL 282

Query: 248 NNLKYNLN-VQNLQVHGLHPRYTHLLVNLPQIVGPVLLLAIFSGY--------------- 291
           N + YN+       ++G  P Y +L+            LA+                   
Sbjct: 283 NIVLYNVFTPHGPDLYGTEPWYFYLIKGF-LNFNVAFALALLVLPLTSLMEYLLQRFHVQ 341

Query: 292 ---KLDKLSTYAIISGLLFLSFFQHQELRFLVPLVPLLVTNLNWTPLSSTL--------- 339
                  L+   +    +      H+E RFL P+ PL+        LS+           
Sbjct: 342 NLGHPYWLTLAPMYIWFIIFFIQPHKEERFLFPVYPLICL-CGAVALSALQKCYHFVFQR 400

Query: 340 --------VNKKIFKGTWLLFNII-----MAFIMGISHQAGIIQFLGDYFHFRTEQMGVH 386
                    +  +  GT  LF ++     +A   G     G +    +++   T+   +H
Sbjct: 401 YRLEHYTVTSNWLALGTVFLFGLLSFSRSVALFRGY---HGPLDLYPEFYRIATD-PTIH 456
>gb|AAH21791.1|AAH21791 (BC021791) Similar to disrupted in bipolar disorder 1 [Mus
           musculus]
          Length = 611

 Score =  315 bits (800), Expect = 1e-84
 Identities = 79/421 (18%), Positives = 136/421 (31%), Gaps = 68/421 (16%)

Query: 8   LYLVYAIGLMLCLGPSYIHPDEHFQCIEILAMQFMKVKGTIPWEFKSKFAARSYGPLLLV 67
              + +  L   L  +    DE F   E      +  KG   WE+   +A RSY  LLL 
Sbjct: 62  FKCLLSARLCAALLSNISDCDETFNYWEP-THYLIYGKGFQTWEYSPVYAIRSYAYLLLH 120

Query: 68  YGPLFTILESFPEIQDNPALILYSMRLQNYVMYLLCYHFLIPKLIRDERKAVQFMQKSLL 127
             P          +Q N  L+ Y +R     +  +C  +    + +     V  M  + L
Sbjct: 121 AWPAAFHAR---ILQTNKILVFYFLRCLLAFVSCVCELYFYKAVCKKFGLHVSRMMLAFL 177

Query: 128 LTSYVTWTYQTHTFSNSIETLALISTLTVMEDMVNEKNIQRSNFKNSVILGLIFSFGVFN 187
           + S   +   +    +S      +  +T                  + I  L  + G   
Sbjct: 178 VLSTGMFCSSSAFLPSSFCMYTTLIAMTGW------------YMDKTPIAVLGVAAGAIL 225

Query: 188 RVTFPAFIFLPCLILFWKFYRVHWKSF-SLLLLSFSFSSCLFVLIDTNIYNNGKGFVITP 246
              F A + LP +       +  WKSF    L++ +      V+ID+  Y      V+ P
Sbjct: 226 GWPFSAALGLP-IAFDLLARKHRWKSFLLWSLVALALFLVPVVVIDSYYY---GKLVVAP 281

Query: 247 LNNLKYNLN-VQNLQVHGLHPRYTHLLVNLPQIVGPVLLLAIFSGY-------------- 291
           LN + YN+       ++G  P Y +L +N          LA+                  
Sbjct: 282 LNIVLYNVFTSHGPDLYGTEPWYFYL-INGFLNFNVAFALALLVLPLTFLMEYLLQRFHV 340

Query: 292 ----KLDKLSTYAIISGLLFLSFFQHQELRFLVPLVPLLVTNLNWTPLSSTL-------- 339
                   L+   +    +      H+E RFL P+ PL+        LS+          
Sbjct: 341 QNLGHPYWLTLAPMYIWFIIFFIQPHKEERFLFPVYPLICL-CGAVALSALQKCYHFVFQ 399

Query: 340 ---------VNKKIFKGTWLLFNII-----MAFIMGISHQAGIIQFLGDYFHFRTEQMGV 385
                     +  +  GT  LF ++     +A   G     G +    +++   T+   +
Sbjct: 400 RYRLEHYTVTSNWLALGTVFLFGLLSFSRSVALFRGY---HGPLDLYPEFYRIATD-PTI 455

Query: 386 H 386
           H
Sbjct: 456 H 456
>dbj|BAB32949.1| (AP002908) putative glycolipid alpha-mannosyltransferase [Oryza
           sativa]
 dbj|BAB84454.1| (AP003546) putative glycolipid alpha-mannosyltransferase [Oryza
           sativa]
          Length = 506

 Score =  314 bits (798), Expect = 2e-84
 Identities = 83/424 (19%), Positives = 152/424 (35%), Gaps = 44/424 (10%)

Query: 5   QWW-LYLVYAIGLMLCLGPSYIHPDEHFQCIEILAMQFMKVKGTIPWEFKSKFAARSYGP 63
           +      +        L  +Y +PDEH+QC+E+ A + +   G + WE+  K   RSY  
Sbjct: 46  RRVLALALAFRAANALLVRTYFNPDEHWQCLEV-AHRIVFGYGHLTWEW--KRGLRSYLH 102

Query: 64  LLLVYGPLFTILESFPEIQDNPALILYSMRLQNYVMYLLCYHFLIPKLIRDERKAVQFMQ 123
              ++  L+ IL       D+P  +  + RL   V       +L           V  M+
Sbjct: 103 P-FIFAALYKILSLLHL--DSPWFMAMAPRLLQSVFASFGDLYLYKLSKLIFNNHVAHME 159

Query: 124 KSLLLTSYVTWTYQTHTFSNSIETLALISTLTVMEDMVNEKNIQRSNFKNSVILGLIFSF 183
             L +T    W         +IE++   S ++       ++   + +  +  +  LI + 
Sbjct: 160 TVLTVTGLYYWFV-------AIESVKGNSVVS------KQQAASKQSPPSRKMALLIAAL 206

Query: 184 GVFNRVTFPAFIFLPCLILFWKFYRVHWKSFSLLL---LSFSFSSCLFVLIDTNIYNNGK 240
               R T          +    F ++  KS  + L       F   +   +D  +Y +  
Sbjct: 207 ACAIRPTS---AITWLYVGLLDFIQMKSKSRFIFLEVVPLGVFVLAVTTFLDCWMYGSR- 262

Query: 241 GFVITPLNNLKYNLNVQNLQVHGLHPRYTHLLVNLPQIVGPVLLLAIFSGYK-LDKLSTY 299
             +I PLN LK+NL       +G H  + +     P ++   L  +I    K  +     
Sbjct: 263 --IIVPLNFLKFNLFSSGGDYYGTHVFHWYFSQGFPSMIWTFLPFSISGILKSREWRLAG 320

Query: 300 AIISGLLFLSFFQHQELRFLVPLVPLLVTNLNWTPLSSTLV------------NKKIFKG 347
            I+  L+  S   H+E RF++P++P +         +   +              K+   
Sbjct: 321 LIVWVLVVYSILGHKEFRFVLPVLPFMFMFSGHNLAAMAQLKGKGHNEKGRLSRLKLSVI 380

Query: 348 TWLLFNIIMAFIMGISHQAGIIQFLGDYFHFRTE--QMGVHIWWKTYSPPTWMYMSNNLT 405
             +L N+ MA  M + HQ G    +        +     V      +S P +  +  NL 
Sbjct: 381 LLILTNVPMALYMSLYHQRGTEDAMLYLSREAHDGRVKSVLFLMPCHSTPYYSTLHYNLP 440

Query: 406 VSSL 409
           +  L
Sbjct: 441 MRFL 444
>gb|AAH09255.1|AAH09255 (BC009255) hypothetical protein FLJ21845 [Homo sapiens]
          Length = 618

 Score =  314 bits (797), Expect = 3e-84
 Identities = 77/427 (18%), Positives = 132/427 (30%), Gaps = 73/427 (17%)

Query: 8   LYLVYAIGLMLCLGPSYIHPDEHFQCIEILAMQFMKVKGTIPWEFKSKFAARSYGPLLLV 67
              + +  L   L  +    DE F   E      +  +G   WE+   +A RSY  LLL 
Sbjct: 62  FKCLLSARLCAALLSNISDCDETFNYWEP-THYLIYGEGFQTWEYSPAYAIRSYAYLLLH 120

Query: 68  YGPLFTILESFPEIQDNPALILYSMRLQNYVMYLLCYHFLIPKLIRDERKAVQFMQKSLL 127
             P          +Q N  L+ Y +R     +  +C  +    + +     V  M  + L
Sbjct: 121 AWPAAFHAR---ILQTNKILVFYFLRCLLAFVSCICELYFYKAVCKKFGLHVSRMMLAFL 177

Query: 128 LTSYVTWTYQTHTFSNSIETLALISTLTVMEDMVNEKNIQRSNFKNSVILGLIFSFGVFN 187
           + S   +   +    +S      +        M      + S     V  G I  +    
Sbjct: 178 VLSTGMFCSSSAFLPSSFCMYTTLIA------MTGWYMDKTSIAVLGVAAGAILGWPFSA 231

Query: 188 RVTFPAFIFLPCLILFWKFYRVHWKSFSLLLLSFSFSSCLFVLIDTNIYNNGKGFVITPL 247
            +  P    L  +   WK +      F   L++        V+ID+  Y      VI PL
Sbjct: 232 ALGLPIAFDLLVMKHRWKSF------FHWSLMALILFLVPVVVIDSYYY---GKLVIAPL 282

Query: 248 NNLKYNLN-VQNLQVHGLHPRYTHLLVNLPQIVGPVLLLAIFSGY--------------- 291
           N + YN+       ++G  P Y +L +N          LA+                   
Sbjct: 283 NIVLYNVFTPHGPDLYGTEPWYFYL-INGFLNFNVAFALALLVLPLTSLMEYLLQRFHVQ 341

Query: 292 ---KLDKLSTYAIISGLLFLSFFQHQELRFLVPLVPLLVTNLNWTPLSSTL--------- 339
                  L+   +    +      H+E RFL P+ PL+        LS+           
Sbjct: 342 NLGHPYWLTLAPMYIWFIIFFIQPHKEERFLFPVYPLICL-CGAVALSALQHSFLYFQKC 400

Query: 340 ---------------VNKKIFKGTWLLFNII-----MAFIMGISHQAGIIQFLGDYFHFR 379
                           +  +  GT  LF ++     +A   G     G +    +++   
Sbjct: 401 YHFVFQRYRLEHYTVTSNWLALGTVFLFGLLSFSRSVALFRGY---HGPLDLYPEFYRIA 457

Query: 380 TEQMGVH 386
           T+   +H
Sbjct: 458 TD-PTIH 463
>ref|NP_079016.1| (NM_024740) disrupted in bipolar disorder 1; similar to putative
           mannosyltransferase Alg9p (S. cerevisiae) [Homo sapiens]
 dbj|BAB15154.1| (AK025498) unnamed protein product [Homo sapiens]
          Length = 618

 Score =  312 bits (792), Expect = 1e-83
 Identities = 77/427 (18%), Positives = 132/427 (30%), Gaps = 73/427 (17%)

Query: 8   LYLVYAIGLMLCLGPSYIHPDEHFQCIEILAMQFMKVKGTIPWEFKSKFAARSYGPLLLV 67
              + +  L   L  +    DE F   E      +  +G   WE+   +A RSY  LLL 
Sbjct: 62  FKCLLSARLCAALLSNISDCDETFNYWEP-THYLIYGEGFQTWEYSPAYAIRSYAYLLLH 120

Query: 68  YGPLFTILESFPEIQDNPALILYSMRLQNYVMYLLCYHFLIPKLIRDERKAVQFMQKSLL 127
             P          +Q N  L+ Y +R     +  +C  +    + +     V  M  + L
Sbjct: 121 AWPAAFHAR---ILQTNKILVFYFLRCLLAFVSCICELYFYKAVCKKFGLHVSRMMLAFL 177

Query: 128 LTSYVTWTYQTHTFSNSIETLALISTLTVMEDMVNEKNIQRSNFKNSVILGLIFSFGVFN 187
           + S   +   +    +S      +        M      + S     V  G I  +    
Sbjct: 178 VLSTGMFCSSSAFLPSSFCMYTTLIA------MTGWYMDKTSIAVLGVAAGAILGWPFSA 231

Query: 188 RVTFPAFIFLPCLILFWKFYRVHWKSFSLLLLSFSFSSCLFVLIDTNIYNNGKGFVITPL 247
            +  P    L  +   WK +      F   L++        V+ID+  Y      VI PL
Sbjct: 232 ALGLPIAFDLLVMKHRWKSF------FHWSLMALILFLVPVVVIDSYYY---GKLVIAPL 282

Query: 248 NNLKYNLN-VQNLQVHGLHPRYTHLLVNLPQIVGPVLLLAIFSGY--------------- 291
           N + YN+       ++G  P Y +L +N          LA+                   
Sbjct: 283 NIVLYNIFTPHGPDLYGTEPWYFYL-INGFLNFNVAFALALLVLPLTSLMEYLLQRFHVQ 341

Query: 292 ---KLDKLSTYAIISGLLFLSFFQHQELRFLVPLVPLLVTNLNWTPLSSTL--------- 339
                  L+   +    +      H+E RFL P+ PL+        LS+           
Sbjct: 342 NLGHPYWLTLAPMYIWFIIFFIQPHKEERFLFPVYPLICL-CGAVALSALQHSFLYFQKC 400

Query: 340 ---------------VNKKIFKGTWLLFNII-----MAFIMGISHQAGIIQFLGDYFHFR 379
                           +  +  GT  LF ++     +A   G     G +    +++   
Sbjct: 401 YHFVFQRYRLEHYTVTSNWLALGTVFLFGLLSFSRSVALFRGY---HGPLDLYPEFYRIA 457

Query: 380 TEQMGVH 386
           T+   +H
Sbjct: 458 TD-PTIH 463
>gb|AAF47795.1| (AE003479) CG12006 gene product [Drosophila melanogaster]
          Length = 512

 Score =  311 bits (789), Expect = 3e-83
 Identities = 92/435 (21%), Positives = 160/435 (36%), Gaps = 77/435 (17%)

Query: 2   MRYQWWLYLVYAIGLMLCLGPS-YIHPDEHFQCIEILAMQFMKVKGTIPWEFKSKFAARS 60
           M+  +   L+ A+ L        Y  PDE++Q +E+ A +     G + WE+      RS
Sbjct: 1   MKLIYVFLLILAVRLASVFVVQTYYVPDEYWQSLEV-AHKLTFGYGYLTWEWVQG--IRS 57

Query: 61  YGPLLLVYGPLFTILESFPEIQDNPALILYSMRLQNYVMYLLCYHFLIPKLIRDERKAVQ 120
           Y   LL+ G L+ IL       D+  L++   R                         ++
Sbjct: 58  YVYPLLIAG-LYKILALLQL--DSAHLLVVLPR-------------------------IR 89

Query: 121 FMQKSLLLTSYVTWTYQTHTFSNSIETLALISTLTVMEDMVNEKNIQRSNFKNSVILGLI 180
                L+L  +  +   + T +N++E       L+              +        + 
Sbjct: 90  KWALFLILVPWFWFYTGSRTLANTLEASLTTIALSYFPWY-------GESTAYLWPAAIC 142

Query: 181 FSFGVFNRVTFPAFIFLPCLILFWKFYRVHWKSFSLLLLSFS----FSSCLFVLIDTNIY 236
                F R T      +   +  +   R       L+L  F       + L + IDT  Y
Sbjct: 143 ----CFLRPTA---AVIWLPLSLYHLRRSRQNVLELILKRFVLIGLLVAGLGIAIDT--Y 193

Query: 237 NNGKGFVITPLNNLKYNLNVQNLQVHGLHPRYTHLLVNLPQIVGPVLLLAIFSG------ 290
            +    ++TP   LKYN+       +G HP + +  V LP ++G   L  IF        
Sbjct: 194 WH-GQLIVTPYEFLKYNIFNNIGSFYGSHPWHWYFSVGLPTVLGINTLPFIFGVMETVKK 252

Query: 291 ---YKLDKLSTYAIISGLLFLSFFQHQELRFLVPLVPLLVTNLNWTP------LSSTLVN 341
              Y + K     I   L+ LS  +H+E RF+ PL+PL +  +           SST++ 
Sbjct: 253 SEKYPVSKQLLITIFLTLVVLSAVEHKEFRFVSPLLPLCLYVITDALSRWSIRASSTMLW 312

Query: 342 KKIFKGTWLLFNIIMAFIMGISHQAGIIQFLG-------DYFHFRTEQMGVHIWWKTYSP 394
                   L+ N++ A+ +   HQ G I+ +        +Y   R  Q  +      +S 
Sbjct: 313 TTAL--VILVGNVMPAWYLSTVHQKGPIELMPKLREIAREYRDEREHQANILFLMPCHST 370

Query: 395 PTWMYMSNNLTVSSL 409
           P + ++  N+T+  L
Sbjct: 371 PYYSHIHQNVTMRFL 385
>sp|Q09837|YADC_SCHPO HYPOTHETICAL 62.2 KD PROTEIN C4G8.12C IN CHROMOSOME I
 pir||S62489 hypothetical protein SPAC4G8.12c - fission yeast
           (Schizosaccharomyces pombe)
 pir||T38857 hypothetical protein SPAC4G8.12c - fission yeast
           (Schizosaccharomyces pombe)
 emb|CAA91213.1| (Z56276) hypothetical protein [Schizosaccharomyces pombe]
          Length = 533

 Score =  299 bits (758), Expect = 1e-79
 Identities = 118/416 (28%), Positives = 197/416 (46%), Gaps = 40/416 (9%)

Query: 9   YLVYAIGLMLCLG----PSYIHPDEHFQCIEILAMQFMKVKGTIPWEFKSKFAARSYGPL 64
            ++Y   L+L        SYIHPDEH Q  +I A +    K  +PWEF +K   RS  PL
Sbjct: 8   AIIYTFLLILRFWFSQGSSYIHPDEHLQSFQIFANKLFGWKVELPWEFTTKKPIRSVVPL 67

Query: 65  LLVYGPLFTILESFPEIQDNPALILYSMRLQNYVMYLLCYHFLIPKLIRDERKAVQFMQK 124
            ++  P+F +     +   +P  IL   RL   ++ LL    +   +  + R +      
Sbjct: 68  NVMLLPIFLLCRCICKSNCSPYPILLFTRLYMCLISLLIDLSIWNIVPLNARWS----AL 123

Query: 125 SLLLTSYVTWTYQTHTFSNSIETLALISTLTVMEDMVNEKNIQRSNFKNSVILGLIFSFG 184
            L  +S++  T+QTHTF+NSIET+    T+  +  + +    ++ ++  + +L ++   G
Sbjct: 124 LLYSSSFMATTFQTHTFTNSIETIFFFLTILFLSKLNSVPLNKKISYLYTFLLAIVSVLG 183

Query: 185 VFNRVTFPAFIFLPCLILFWKFYRVHWK------SFSLLLLSFSFSSCLFVLIDTNIYNN 238
            F R+TF AF+  P +    + ++ +            + +S SF++ L  +++   Y  
Sbjct: 184 FFTRITFLAFVIAPYIYFSVRCFKKNVNNPKDIFLHLCIFVSVSFATVLACILED--YKF 241

Query: 239 GKGFVITPLNNLKYNLNVQNLQVHGLHPRYTHLLVNLPQIVGPVLLLAIFSGYKLDKLST 298
              FVIT  NNLKYN  ++NL  HGLH R TH   N+P + GP++ +     + + K +T
Sbjct: 242 YGVFVITFWNNLKYNSQIENLSQHGLHSRLTHFFTNMPLLCGPLIFVPKL--WDVRKPAT 299

Query: 299 YAIISGLLFLSFFQHQELRFLVPLVPLLVTNLNWTPLSSTLVNKKIFKGTWLLFNIIMAF 358
           +  +  +  LS F HQE RFL+P   + + N         LV     K  ++++ +++A 
Sbjct: 300 WLWLLPVFILSLFPHQEPRFLLPAASIFIVNSGC------LVRSYWIKFLFVMYAVVLAV 353

Query: 359 IMGISHQAGIIQFLGDY----------------FHFRTEQMGVHIWWKTYSPPTWM 398
             GI HQ G+I  + +                  +F  E      +WK YS PTWM
Sbjct: 354 FFGIMHQNGVIPAVLEVKNIIEQRNVTTMENCNLYFNPEMPTTIYFWKIYSAPTWM 409
>pir||T41079 probable alpha 1,2 mannosyltransferase - fission yeast
           (Schizosaccharomyces pombe)
 emb|CAB53078.1| (AL109957) putative alpha 1,2 mannosyltransferase
           [Schizosaccharomyces pombe]
          Length = 506

 Score =  293 bits (745), Expect = 3e-78
 Identities = 79/427 (18%), Positives = 152/427 (35%), Gaps = 43/427 (10%)

Query: 1   MMRYQWWLYLVYAIGLMLCLGPSYIHPDEHFQCIEILAMQFMKVKGTIPWEFKSKFAARS 60
           ++ ++WW  L            ++  PDE +Q +E+ A  F+   G + WE+ S  A RS
Sbjct: 9   ILVFRWWNAL---------WVKTFFQPDEFYQSLEV-AHHFIFRYGFLTWEWTS--AIRS 56

Query: 61  YGPLLLVYGPLFTILESFPEIQDNPALILY-SMRLQNYVMYLLCYHFLIPKLIRDERKAV 119
                L++  L+ +L+      D+   +   + +L       +  +      +       
Sbjct: 57  ALHP-LIFAALYRVLQVLKL--DSSYFVFTNAPKLLQGTFAAILDYGTYKFALVRYGSKT 113

Query: 120 QFMQKSLLLTSYVTWTYQTHTFSNSIETLALISTLTVMEDM--VNEKNIQRSNFKNSVIL 177
                +  L S +       TFSNS+ET                   + ++     S +L
Sbjct: 114 ANWTLACSLVSIMNAYVGVRTFSNSLETTLTSIGFYYFSYYLKYENSSPEQRKKAYSSLL 173

Query: 178 GLIF--SFGVFNRVTFPAFIFLPC---------LILFWKFYRVHWKSFSLLLL------- 219
           G I   +F  F R T       P           I     +   +  F  L         
Sbjct: 174 GFISVAAFACFIRPTNILVWIFPLLFWNKNPQTPIKDLLSFSNVFNRFRFLYALGYGRLF 233

Query: 220 -SFSFSSCLFVLIDTNIYNNGKGFVITPLNNLKYNLNVQNLQVHGLHPRYTHLLVNLPQI 278
             F     LF++           FV   ++  ++N+      ++GL+  + +L   LP I
Sbjct: 234 GIFVLCVSLFLVNIIADRILYGRFVFPIISFFQFNVTSGLSSLYGLNAWHYYLSQALPLI 293

Query: 279 VGPVLLLAIFSGYKLDKLSTYAIISGLLFLSFFQHQELRFLVPLVPLLVTNLNWTPLSST 338
            G  L   + +   +D  +   I+      S   H+ELRF+ P+ P+L+T       SS 
Sbjct: 294 CGGFLPFVLLT---MDLQTAGTILCVFFPYSLIGHKELRFVYPISPILLTLAG-KFFSSF 349

Query: 339 LVNKKIFKGTWL--LFNIIMAFIMGISHQAGIIQFLGDYFHFRTEQMGVHIWWKTYSPPT 396
              K+  +  +L  L + ++   +   HQ G+++ +        +     I    ++ P 
Sbjct: 350 SSWKRAARFFFLIGLGHALVITFLCRFHQFGVMEVMPLIHSLAEKNQTGLILAPCHTTPW 409

Query: 397 WMYMSNN 403
             ++ + 
Sbjct: 410 QSHIHSP 416
>ref|NP_079439.1| (NM_025163) hypothetical protein FLJ12768 [Homo sapiens]
 dbj|BAB14263.1| (AK022830) unnamed protein product [Homo sapiens]
          Length = 579

 Score =  278 bits (705), Expect = 2e-73
 Identities = 128/453 (28%), Positives = 182/453 (39%), Gaps = 73/453 (16%)

Query: 1   MMRYQWWLYLVYAIGLMLCLGPS--YIHPDEHFQCIEILAMQFMKVKGTIPWEFKSKFAA 58
           M     W  L   + ++ CL P   Y+HPDE FQ  E++A   + V+   PWEF    + 
Sbjct: 32  MAVRVLWGGLSL-LRVLWCLLPQTGYVHPDEFFQSPEVMAEDILGVQAARPWEFYPSSSC 90

Query: 59  RSYGPLLLVYGPLFTILESFPEIQDNPALI-----LYSMRLQNYVMYLLCY---HFLIPK 110
           RS    LL+ G  F +L  + E+   P L+     L   RL    +        + L P 
Sbjct: 91  RSVLFPLLISGSTFWLLRLWEELGPWPGLVSGYALLVGPRLLLTALSFALDGAVYHLAPP 150

Query: 111 LIRDERKAVQFMQKSLLLTSYVTWTYQTHTFSNSIETLALISTLTVMEDMVNEKNIQRSN 170
           +  D          +LL  SYVT  + T TFSN+IE L     L ++   V     ++  
Sbjct: 151 MGADRWN-----ALALLSGSYVTLVFYTRTFSNTIEGLLFTWLLVLVSSHVTWGPTRKEP 205

Query: 171 FKN----SVILGLIFSFGVFNRVTFPAFIFLPCLILFWKFYRVH---WKSFS----LLLL 219
                  S +LG I + G FNR TF AF  +P     W          KS +    +LL 
Sbjct: 206 APGPRWRSWLLGGIVAAGFFNRPTFLAFAVVPL--YLWGTRGATNPGLKSLTREALVLLP 263

Query: 220 SFSFSSCLFVLIDTNIYNN---GKGFVITPLNNLKYNLNVQNLQVHGLHPRYTHLLVNLP 276
             + ++ +FV  D+  +++    +  V+TP+N L YNLN QNL  HG H R THL VN  
Sbjct: 264 GATLTAAVFVATDSWYFSSPATSRNLVLTPVNFLHYNLNPQNLARHGTHARLTHLAVNGF 323

Query: 277 QIVGPVLLLAIF--------------------------SGYKLDKLSTYAIISGLLFLSF 310
            + G +   A+                                           L  LS 
Sbjct: 324 LLFGVLHAQALQAAWQQLQVGLQASAQMGLLRALGARSLLSSPRSYLLLLYFMPLALLSA 383

Query: 311 FQHQELRFLVPLVPLLVTNLNWTPLSSTLVNKKIFKGTWLLFNIIMAFIMGISHQAGIIQ 370
           F HQE RFL+PL+  LV         S       +KGT +LFN + A + G  HQ G++ 
Sbjct: 384 FSHQEARFLIPLLVPLVLLC------SPQTQPVPWKGTVVLFNALGALLFGCLHQGGLVP 437

Query: 371 FLGDYFHFRTEQMG--------VHIWWKTYSPP 395
            L +Y                   ++  TY PP
Sbjct: 438 GL-EYLEQVVHAPVLPSTPTHYTLLFTHTYMPP 469
>emb|CAD22101.1| (AJ429133) putative mannosyltransferase [Mus musculus]
          Length = 483

 Score =  269 bits (683), Expect = 6e-71
 Identities = 60/398 (15%), Positives = 114/398 (28%), Gaps = 41/398 (10%)

Query: 7   WLYLVYAIGLMLCLGPSYIHPDEHFQCIEILAMQFMKVK----GTIPWEFKSKFAARSYG 62
            L  V  I L++C    Y   +E F          +  +         EF      R++ 
Sbjct: 17  LLVTVATIHLVIC---PYTKVEESFNL--QATHDLLYHQLDIDKYDHHEF-PGVVPRTFL 70

Query: 63  PLLLVYG---PLFTILESFPEIQDNPALILYSMRLQNYVMYLLCYHFLIPKLIRDERKAV 119
             L++     P+  +L      +    LI   +R    +  +     L  ++ +     V
Sbjct: 71  GPLVIAAFSSPVVYVLSLLEVSKFYSQLI---VRGVLGLGVISGLWTLQKEVRQQFGATV 127

Query: 120 QFMQKSLLLTSYVTWTYQTHTFSNSIETLALISTLTVMEDMVNEKNIQRSNFKNSVILGL 179
             M   +  T +    Y T T  N +    ++  LT           QR        L  
Sbjct: 128 AVMFCWISATQFHLMFYCTRTLPNVLALAVVLPALTAWL--------QRRWALFVW-LSA 178

Query: 180 IFSFGVFNRVTFPAFIFLPCLILFWKFYRVHWKSFSLLLLSFSFSSCLFVLIDTNIYNNG 239
               G    +     I L   +   +           +         L V +D+  +   
Sbjct: 179 FVIIGFRAELAMLLGIALLLTLYQRRLTVARV-LRHAIPAGL-LCLGLTVAVDSYFW--- 233

Query: 240 KGFVITPLNNLKYNLNVQNLQVHGLHPRYTHLLVNLPQIVGPVLLLAIFSGYKLD-KLST 298
           +  V      L YN  +      G  P   +    LP+ +G  LL               
Sbjct: 234 RYLVWPEGVVLGYNTVLNKSSNWGTSPLLWYFYSALPRGLGCSLLFIPLGAVDRRTYALA 293

Query: 299 YAIISGLLFLSFFQHQELRFLVPLVPLLVTNL--NWTPLSSTLVNKKIFKGTWLLFNIIM 356
              +  +   S   H+ELRF++   P+L        T + +        +   +  +I++
Sbjct: 294 LPSLGFVALYSLLPHKELRFIIYTFPVLNIMAARGCTYILNKKSWPYKVRAMLVTGHILV 353

Query: 357 -------AFIMGISHQAGIIQFLGDYFHFRTEQMGVHI 387
                  +  +   +  G +  +         Q  V +
Sbjct: 354 NVAYTATSLYVSHFNYPGGV-AMQQLHELVPPQTDVLL 390
>gb|AAF54441.1| (AE003684) CG8412 gene product [Drosophila melanogaster]
 gb|AAL48754.1| (AY071132) RE17513p [Drosophila melanogaster]
          Length = 678

 Score =  267 bits (677), Expect = 3e-70
 Identities = 53/376 (14%), Positives = 106/376 (28%), Gaps = 47/376 (12%)

Query: 5   QWWLYLVYAIGLMLCLGPSYIHPDEHFQCIEILAMQFMK----VKGTIPWEFKSKFAARS 60
                   A  +           +E F          +            ++      R+
Sbjct: 3   ILIFVTAAAHLVYTPFT----KVEESFNL--QAMHDILYLRNNFTQYDHHDY-PGVVPRT 55

Query: 61  YGPLLL---VYGPLFTILESFPEIQDNPALILYSMRLQNYVMYLLCYHFLIPKLIRDERK 117
           +   L+   +  P   + E+    +       Y +RL       + ++ L   + +    
Sbjct: 56  FIGPLVVSIISAPFVLLFETLSINKFWAQ---YVVRLVLAGAISVAWNSLRQAVTKIYGV 112

Query: 118 AVQFMQKSLLLTSYVTWTYQTHTFSNSIETLALISTLTVMEDMVNEKNIQRSNFKNSVIL 177
            V+    ++ +T +    Y T    N      ++  +            Q   F   +I 
Sbjct: 113 EVRLWFTAITITQFHFMFYMTRPLPNIFALPIVLFAIAYWLR------DQHKPF---IIC 163

Query: 178 GLIFSFGVFNRVTFPAFIFLPCLILFWKFYRVHWKSFSLLLLSFSFSSCLFVLIDTNIYN 237
             I    VF          L  + L  +   +       L           VL+D+  + 
Sbjct: 164 SGISIL-VFRSELALFLGILLVVSLLRRKVSIDGLLKVALPAGVCI-LAATVLVDSFFW- 220

Query: 238 NGKGFVITPLNNLKYNLNVQNLQVHGLHPRYTHLLVNLPQIVGPVLLLAIFSGY--KLDK 295
             +  +      L YN  +      G  P   +    LP+ +G  L+L           +
Sbjct: 221 --RRLLWPEGEVLWYNTVLNKSSNWGTSPFLWYFYSALPRAMGASLVLVPIGVALEPRIR 278

Query: 296 LSTYAIISGLLFLSFFQHQELRFLVPLVPLLVTNLNWTPLSSTLVNKKIFKGTW------ 349
               + +  +L  S   H+ELRF++ + P+L             +     K TW      
Sbjct: 279 PLVLSALLFVLLYSILPHKELRFIIYVFPVLNIAAACACQR---IWMNSAKSTWHSFLAL 335

Query: 350 -----LLFNIIMAFIM 360
                LL N+ +   +
Sbjct: 336 ACGAHLLLNVFITLFL 351
>dbj|BAA94863.1| (AB033824) GPI anchor biosynthesis protein [Trypanosoma brucei]
          Length = 558

 Score =  266 bits (674), Expect = 7e-70
 Identities = 80/460 (17%), Positives = 159/460 (34%), Gaps = 89/460 (19%)

Query: 6   WWLYLVYAIGLMLCLGPSYIH-PDEHFQCIEILAMQFMKVKGTIPWEFKSKFAARSYGPL 64
           W + L +   L LC     +  PDE +Q  E+ A   +  KG +PWE+  ++  RS    
Sbjct: 4   WLISLTFIYRLFLCATIRTVEAPDEWWQSTEV-AYNMVFGKGHLPWEW--RYGLRSVLFP 60

Query: 65  LLVYGPLFTILESFPEIQDNPALILYSMRLQNYVMYLLCYHFLIP--------------- 109
            +V  P + +L+           + ++ R+   ++  L    +                 
Sbjct: 61  AVVALPFY-LLKLLGRDTTWA--VWFAPRVLQALVLTLIDVSVFCMGATLDELLAKRELE 117

Query: 110 -------------------KLIRDER---KAVQFMQKSLLLTSYVTWTYQTHTFSNSIET 147
                               + R  R    ++ +    L L+++         + N IE 
Sbjct: 118 LAEETRQSKTKGFSYFCEVSVSRSRRGICNSISYTALLLSLSNWYMAYCGVRLYGNVIEA 177

Query: 148 LALISTLTVMEDMVNEKNIQRSNFKNSVILGLIFSFGVFNRVTFPAFIFLPCLI------ 201
           L ++ TL            QR      ++ GL  +  V + V     +F           
Sbjct: 178 LLVLLTL-----------QQRRYVPFLLLTGLASAIRVTSAVVLSPLVFRHLANATREHG 226

Query: 202 LFWKFYRVHWKSFSLLLLSFSFSSCLFVLIDTNIYNNGKGFVITPLNNLKYNLNVQNLQV 261
                +R+      +L+        L        Y     +V+TPL   ++N+     + 
Sbjct: 227 FIRGLFRIVLTGLIVLVAVLGGVMVL-------DYCFYGRWVLTPLAFFRFNVLHNLSRF 279

Query: 262 HGLHPRYTHLLVNLPQIVGPVLLLAIFSGYKLD------------KLSTYAI---ISGLL 306
            G HP Y ++    P +VG V    +F+                 +     +      L 
Sbjct: 280 FGEHPWYFYV---GPVLVGIVGPHVLFTIAAPLVLWRDTASRAVSRPVLGMLGIGAWTLG 336

Query: 307 FLSFFQHQELRFLVPLVPLLVTNLNWTPLSSTLVNKKIFK--GTWLLFNIIMAFIMGISH 364
           F S   H+E+RF+  ++PL +    +  +  +  +  + K    ++LFNI+M ++MG  +
Sbjct: 337 FYSLIDHKEMRFVFVVIPLSLITAAFVLVRWSRTSAVVVKMNRLFVLFNIVMIYLMGYVY 396

Query: 365 QAGIIQFLGDYFHFRTEQMGVHIWWKTYSPPTWMYMSNNL 404
           + G +  + +          + +    Y+ P + YM   +
Sbjct: 397 RRGPLDVMAEVRD-GPRINRLDVIATCYTVPGYSYMHKKV 435
>ref|XP_081472.1| (XM_081472) CG11851 [Drosophila melanogaster]
 gb|AAF56419.1| (AE003751) CG11851 gene product [Drosophila melanogaster]
 gb|AAL39788.1| (AY069643) LD40966p [Drosophila melanogaster]
          Length = 623

 Score =  265 bits (673), Expect = 1e-69
 Identities = 71/413 (17%), Positives = 126/413 (30%), Gaps = 63/413 (15%)

Query: 8   LYLVYAIGLMLCLGPSYIHPDEHFQCIEILAMQFMKVKGTIPWEFKSKFAARSYGPLLLV 67
                +  L   +       DE F   E L    +   G   WE+  +F  RSY  LLL 
Sbjct: 77  FKTFVSARLCSAIWAYIADCDETFNYWEPL-HYIINGHGLQTWEYSPQFGLRSYTYLLLQ 135

Query: 68  YGPLFTILESFPEIQDNPALILYSMRLQNYVMYLLCYHFLIPKLIRDERKAVQFMQKSLL 127
             P +   +       +P LI Y +R        +   ++   + ++    +  +     
Sbjct: 136 GVPGYFYQKL---FNPSPILIFYMVRCMLGFGCAVMERYMYKSICQEFGIHIGRLWLIFQ 192

Query: 128 LTSYVTWTYQTHTFSNSIETLALISTLTVMEDMVNEKNIQRSNFKNSVILGLIFSFGVFN 187
           L S   +   T    +S       + L                         + +     
Sbjct: 193 LFSVGMFVSSTALLPSSFSMYFGCAALAAWWQQNYC------------FAIFLTAISALL 240

Query: 188 RVTFPAFIFLPCLILFWKFYRVHWKSF-SLLLLSFSFSSCLFVLIDTNIYNNGKGFVITP 246
              F A I +P ++      +  WK+F    L+S +  +   + IDT+ +         P
Sbjct: 241 GWPFAALIGIPLVL-EMLLRQRDWKTFVQWTLISGATVAIPMIAIDTSYF---GKLTFAP 296

Query: 247 LNNLKYNLN-VQNLQVHGLHPRYTHLLVNLPQIVGPVLLLAIFSGYKLD----------- 294
           LN + YN+       + G  P   ++ +N       + LLA+     L            
Sbjct: 297 LNIVWYNVFTSHGPNIFGTEPLSYYI-INGFLNFNIIWLLALQLPIMLVIDYLIVPAKSK 355

Query: 295 -------KLSTYAIISGLLFLSFFQHQELRFLVPLVPLLVTNLNWT-------PLSSTLV 340
                   +S   +   LL      H+E RFL P+ PL+      T             V
Sbjct: 356 STLNFPHYISLAPLYLWLLVFFAQPHKEERFLFPIYPLISLCGAITVDVYQRIFFRMKSV 415

Query: 341 NKKIFKGTWLLFNIIMA--------FIMGIS-------HQAGIIQFLGDYFHF 378
             KI  G   L + +           ++G+S       +    +  + +   F
Sbjct: 416 VFKIKAGVHYLDHSMFIAILVMVTSTLLGLSRVFALYRNYHAPMDLMLELNQF 468
>pir||T50116 probable mannosyltransferase involved in N-glycosylation [imported]
           - fission yeast (Schizosaccharomyces pombe)
 emb|CAB75773.1| (AL157734) putative mannosyltransferase involved in N-glycosylation
           [Schizosaccharomyces pombe]
          Length = 577

 Score =  264 bits (669), Expect = 3e-69
 Identities = 63/356 (17%), Positives = 123/356 (33%), Gaps = 32/356 (8%)

Query: 4   YQWWLYLVYAIGLMLCLGPSYIHPDEHFQCIEILAMQFMKVKGTIPWEFKSKFAARSYGP 63
           + W   ++  + L           DE +   E L    +   G   WE+  ++A RS+  
Sbjct: 14  FVWTFSILAVLRLTSASFRVIDDCDEVYNYWEPL-HYLLYGYGLQTWEYSPEYAIRSWFY 72

Query: 64  LLLVYGPLFTILESFPEIQDNPALILYSMRLQNYVMYLLCYHFLIPKLIRDERKAVQFMQ 123
           + L   P F           +   + Y +R         C   LI  + R+  +AV    
Sbjct: 73  IALHAVPGFLARGL----GLSRLHVFYFIRGVLACFSAFCETNLILAVARNFNRAVALHL 128

Query: 124 KSLLLTSYVTWTYQTHTFSNSIETLALISTLTVMEDMVNEKNIQRSNFKNSVILGLIFSF 183
            S+L  +   W+  T    +S     +   L+     ++  + +R+    S I       
Sbjct: 129 TSVLFVNSGMWSASTSFLPSSFAMNMVTLALSA---QLSPPSTKRTVKVVSFITIGAVIG 185

Query: 184 GVFNRVTFPAFIFLPCLILFWKFYRVHWKSFSLLLLSFSFSSCLFVLIDTNIYNNGKGFV 243
             F+      FI L  + L  +F  +  + F  + ++   +     +   +++ +   FV
Sbjct: 186 WPFSAALSIPFILLELVDLKGRFRHLFCRWFKAIFVALLIT--GICITVDSLFYHRIQFV 243

Query: 244 ITPLNNLKYNLNVQ---NLQVHGLHPRYTHLLVN---------LPQIVGPVLLLAIFSGY 291
               N +KYN+  +      ++G  P + +                  GP++LLA F+ +
Sbjct: 244 --AWNIVKYNVLAKDGRGPDIYGTEPWWYYFANLSLQHNIVLWFAMACGPLVLLAAFTNW 301

Query: 292 -------KLDKLSTYAIISGLLFLSFFQHQELRFLVPLVPLLVTNLNWTPLSSTLV 340
                   L  + +      L       H+E RF+ P+ P+L          S  +
Sbjct: 302 INLDSFLDLSSVIS-PFYIWLFIFIIQPHKEERFMYPIYPVLCLAAAIGLDMSLKL 356
>ref|NP_077010.1| (NM_024105) hypothetical protein MGC3136 [Homo sapiens]
 gb|AAH01729.1|AAH01729 (BC001729) Unknown (protein for MGC:3136) [Homo sapiens]
 emb|CAC67488.1| (AJ303120) putative alpha mannosyltransferase [Homo sapiens]
 gb|AAL55850.1|AF318343_1 (AF318343) unknown [Homo sapiens]
          Length = 488

 Score =  253 bits (640), Expect = 7e-66
 Identities = 58/400 (14%), Positives = 111/400 (27%), Gaps = 43/400 (10%)

Query: 7   WLYLVYAIGLMLCLGPSYIHPDEHFQCIEILAMQFMKV----KGTIPWEFKSKFAARSYG 62
            L  V  + L++C    Y   +E F          +      +     EF      R++ 
Sbjct: 16  LLVAVATVHLVIC---PYTKVEESFNL--QATHDLLYHWQDLEQYDHLEF-PGVVPRTFL 69

Query: 63  PLLLVYG---PLFTILESFPEIQDNPALILYSMRLQNYVMYLLCYHFLIPKLIRDERKAV 119
             +++     P   +L      +    LI   +R    +  +     L  ++ R     V
Sbjct: 70  GPVVIAVFSSPAVYVLSLLEMSKFYSQLI---VRGVLGLGVIFGLWTLQKEVRRHFGAMV 126

Query: 120 QFMQKSLLLTSYVTWTYQTHTFSNSIETLALISTLTVMEDMVNEKNIQRSNFKNSVILGL 179
             M   +    +    Y T T  N +    ++  L                     I   
Sbjct: 127 ATMFCWVTAMQFHLMFYCTRTLPNVLALPVVLLALAAWLRHEWA----------RFIWLS 176

Query: 180 IFSFGVFNRVTFPAFIFLPCLILFWKFYRVHWKSFSLLLLSFSFSSCLFVLIDTNIYNNG 239
            F+  VF          L  L L  +   V       +         L V +D+  +   
Sbjct: 177 AFAIIVFRVELCLFLGLLLLLALGNRKVSVVRALRHAVPAGI-LCLGLTVAVDSYFW--- 232

Query: 240 KGFVITPLNNLKYNLNVQNLQVHGLHPRYTHLLVNLPQIVGPVLLLAIFSGYKLD-KLST 298
           +         L YN  +      G  P   +    LP+ +G  LL              T
Sbjct: 233 RQLTWPEGKVLWYNTVLNKSSNWGTSPLLWYFYSALPRGLGCSLLFIPLGLVDRRTHAPT 292

Query: 299 YAIISGLLFLSFFQHQELRFLVPLVPLLVTNLN----WTPLSSTLVNKKIFKGTWLLFNI 354
              +  +   S   H+ELRF++   P+L         +   +             ++ ++
Sbjct: 293 VLALGFMALYSLLPHKELRFIIYAFPMLNITAARGCSYLLNNYKKSWLYKAGSLLVIGHL 352

Query: 355 IM-------AFIMGISHQAGIIQFLGDYFHFRTEQMGVHI 387
           ++       A  +   +  G +  +         Q  V +
Sbjct: 353 VVNAAYSATALYVSHFNYPGGV-AMQRLHQLVPPQTDVLL 391
>emb|CAC83681.1| (AJ290427) putative dolichyl-p-man: Man7GlcNAc2-PP-dolichyl
           mannosyltransferase [Homo sapiens]
          Length = 488

 Score =  252 bits (638), Expect = 1e-65
 Identities = 58/400 (14%), Positives = 111/400 (27%), Gaps = 43/400 (10%)

Query: 7   WLYLVYAIGLMLCLGPSYIHPDEHFQCIEILAMQFMKV----KGTIPWEFKSKFAARSYG 62
            L  V  + L++C    Y   +E F          +      +     EF      R++ 
Sbjct: 16  LLVAVATVHLVIC---PYTKVEESFNL--QATHDLLYHWQDLEQYDHLEF-PGVVPRTFL 69

Query: 63  PLLLVYG---PLFTILESFPEIQDNPALILYSMRLQNYVMYLLCYHFLIPKLIRDERKAV 119
             +++     P   +L      +    LI   +R    +  +     L  ++ R     V
Sbjct: 70  GPVVIAVFSSPAVYVLSLLEMSKFYSQLI---VRGVLGLGVIFGLWTLQKEVRRHFGAMV 126

Query: 120 QFMQKSLLLTSYVTWTYQTHTFSNSIETLALISTLTVMEDMVNEKNIQRSNFKNSVILGL 179
             M   +    +    Y T T  N +    ++  L                     I   
Sbjct: 127 ATMFCWVTAMQFHLMVYCTRTLPNVLALPVVLLALAAWLRHEWA----------RFIWLS 176

Query: 180 IFSFGVFNRVTFPAFIFLPCLILFWKFYRVHWKSFSLLLLSFSFSSCLFVLIDTNIYNNG 239
            F+  VF          L  L L  +   V       +         L V +D+  +   
Sbjct: 177 AFAIIVFRVELCLFLGLLLLLALGNRKVSVVRALRHAVPAGI-LCLGLTVAVDSYFW--- 232

Query: 240 KGFVITPLNNLKYNLNVQNLQVHGLHPRYTHLLVNLPQIVGPVLLLAIFSGYKLD-KLST 298
           +         L YN  +      G  P   +    LP+ +G  LL              T
Sbjct: 233 RQLTWPEGKVLWYNTVLNKSSNWGTSPLLWYFYSALPRGLGCSLLFIPLGLVDRRTHAPT 292

Query: 299 YAIISGLLFLSFFQHQELRFLVPLVPLLVTNLN----WTPLSSTLVNKKIFKGTWLLFNI 354
              +  +   S   H+ELRF++   P+L         +   +             ++ ++
Sbjct: 293 VLALGFMALYSLLPHKELRFIIYAFPMLNITAARGCSYLLNNYKKSWLYKAGSLLVIGHL 352

Query: 355 IM-------AFIMGISHQAGIIQFLGDYFHFRTEQMGVHI 387
           ++       A  +   +  G +  +         Q  V +
Sbjct: 353 VVNAAYSATALYVSHFNYPGGV-AMQRLHQLVPPQTDVLL 391
>ref|NP_011373.1| (NC_001139) Involved in glycosyl phosphatidyl inositol synthesis;
           could be the target of the GPI synthesis inhibitor,
           YW3548; Most likely an alpha 1,2 mannosyltransferase
           utilized for the addition of the third mannose onto the
           GPI core structure.; Gpi1>
 sp|P30777|YGO2_YEAST Hypothetical 72.6 kDa protein in MRF1-HUL5 intergenic region
 pir||S64156 probable membrane protein YGL142c - yeast (Saccharomyces
           cerevisiae)
 emb|CAA96854.1| (Z72664) ORF YGL142c [Saccharomyces cerevisiae]
 emb|CAA68220.1| (X99960) putative, YGL142c [Saccharomyces cerevisiae]
          Length = 616

 Score =  244 bits (618), Expect = 3e-63
 Identities = 77/429 (17%), Positives = 143/429 (32%), Gaps = 58/429 (13%)

Query: 1   MMRYQWWLYLVYAIGLMLCLGPSYIHPDEHFQCIEILAMQFMKVKGTIPWEFKSKFAARS 60
           ++ Y   L       L++ L P Y   +  +Q  E       +    +P++       RS
Sbjct: 88  LLHYALLLLSTIGSDLLILLLPKY---ELSWQVAE----DLKR----LPFDVT-----RS 131

Query: 61  YGPLLLVYGP--LFTILESFPEIQDNPALILYSMRLQNYVMYLLCYHFLIPKLIRDERK- 117
           +    ++Y P  +  +L S  E         Y +R    +  L        +        
Sbjct: 132 FEYYGVIYAPKIVMAVLASIGE--------YYIVRFVQKLYLLTLDKRNEKEEEERRSGL 183

Query: 118 -AVQFMQKSLLLTSYVTWTYQTHTFSNSIETLALISTLTVMEDMVNEKNIQRSNFKNSVI 176
             +      L LT++    + T TF NS E +     L    D    + I+ S+F  S+I
Sbjct: 184 SEITKFALLLSLTNFFNCFFITRTFINSFEMILTSIALYYW-DWTGGQMIKESSFTKSLI 242

Query: 177 LGLIFSFGVFNRVTFPAFIFLPCLILFWKFYRVHWKSFSLLLLSFSFSS----CLFVLID 232
                      R +      +P + L         K + LL ++FS        +F    
Sbjct: 243 FAF---LACLQRPSSGLIWVIPSISLILNLVGK--KQYHLLFITFSKVLRSFFLVFTANA 297

Query: 233 TNIYNNGKGFVITPLNNLKYNLNVQNLQVHGLHPRYTHLLVNLPQIVGPVLLLAIFSGYK 292
                  +         LK+N      + +G+ P + H   +LP ++G  +    F  + 
Sbjct: 298 IIDMYFYEKVTFPFFRFLKFNFTTPLSKFYGVAPWHFHFFQSLPIVLGASIPAFAFGLFF 357

Query: 293 LDK-------------LSTYAIISGLLFLSFFQHQELRFLVPLVPLLVTNLNWTPLS--- 336
                                I+  LL  S   H+E RF+ PL PL +   ++  L    
Sbjct: 358 PLSKRSFPKKYLNPFFQVKLTILLNLLVYSTLPHKEFRFIFPLQPLFILISSFGLLRLDR 417

Query: 337 --STLVNK-KIFKGTWLLFNIIMAFIMGISHQAGIIQFLGDYFHFRTEQMGVHIWWKTYS 393
                ++  K         ++ +A ++   H++G I+ +  + H   E   +      +S
Sbjct: 418 DYWKRLSGLKSLLWLVPFVSVFIALLLDTFHESGSIEVM-KFLHEEPEIDSLGFIMPCHS 476

Query: 394 PPTWMYMSN 402
            P   Y+  
Sbjct: 477 TPGQSYLHR 485
 Score = 41.5 bits (97), Expect = 0.031
 Identities = 16/61 (26%), Positives = 24/61 (39%), Gaps = 5/61 (8%)

Query: 6  WWLYLVYAIGLMLCLGPSYIHPDEHFQCIEILAMQFMKVKGTIPWEFKSKFAARSYGPLL 65
          W         L   L  ++   DE +Q +E  A       G + WE+  KF  RSY   +
Sbjct: 19 WVFL--AFRVLNAVLTRTFFQADEFWQALEP-AHWKAFKYGELTWEW--KFGVRSYLFPM 73

Query: 66 L 66
          +
Sbjct: 74 I 74
>ref|NP_173134.1| (NM_101551) Ser/Thr protein kinase, putative [Arabidopsis thaliana]
          Length = 919

 Score =  244 bits (617), Expect = 3e-63
 Identities = 67/344 (19%), Positives = 119/344 (34%), Gaps = 37/344 (10%)

Query: 4   YQWWL-YLVYAIGLMLCLGPSYIH-PDEHFQCIEILAMQFMKVKGTIPWEFKSKFAARSY 61
            +W+L ++       +    + IH  DE F   E L    +   G   WE+ S FA RSY
Sbjct: 393 LRWFLPFIALCYLRYMSATSNIIHDCDEVFNYWEPL-HYILYKSGFQTWEYSSNFALRSY 451

Query: 62  GPLLLVYGPLFTILESFPEIQDNPALILYSMRLQNYVMYLLCYHFLIPKLIRDERKAVQF 121
               +++  L     S+    D+   + Y++RL   ++  +    L+  L R   K +  
Sbjct: 452 LY--ILFHELAGRPASWW-FGDDKVRVFYAVRLFLGLVSAVSDTVLVVALSRKYGKRIAT 508

Query: 122 MQKSLLLTSYVTWTYQTHTFSNSIETLA--LISTLTVMEDMVNEKNIQRSNFKNSVILGL 179
              ++L  +   +   T    +S    A  L S L + E                 +   
Sbjct: 509 YAVAMLCLTSGCFFASTSFLPSSFSMYAISLSSGLLLFEKYA--------------MAVA 554

Query: 180 IFSFGVFNRVTFPAFIFLPCLILFWKFYRVHWKSFSLLLLSFSFSSCLFVLIDTNIYNNG 239
           +   GV     F    FLP +I         +K   +     +       L+    Y   
Sbjct: 555 VSVVGVILGWPFSILAFLPVVIYSLVKR---FKQAFIAGAVTTIFLLGVSLLVDYYY--Y 609

Query: 240 KGFVITPLNNLKYNLNVQN-LQVHGLHPRYTHL--------LVNLPQIVGPVLLLAIFSG 290
           K +  + LN L YN+       ++G      ++           +  ++   +   I   
Sbjct: 610 KRWTSSVLNLLIYNVLGGGESHLYGTEGALFYIRNGFNNFNFCFILAMLFVAIYPVIRRK 669

Query: 291 YKLDKLSTY-AIISGLLFLSFFQHQELRFLVPLVPLLVTNLNWT 333
           Y    L     +   L F+S   H+E RFL P+ PL+  + +  
Sbjct: 670 YDRALLVVISPMYIWLAFMSLQPHKEERFLYPIYPLICVSASAV 713
>ref|NP_505071.1| (NM_072670) ZC513.5.p [Caenorhabditis elegans]
 gb|AAC48267.3| (U53155) Hypothetical protein ZC513.5 [Caenorhabditis elegans]
          Length = 492

 Score =  241 bits (610), Expect = 2e-62
 Identities = 44/363 (12%), Positives = 115/363 (31%), Gaps = 29/363 (7%)

Query: 7   WLYLVYAIGLMLCLGPSYIHPDEHFQCIEILAMQFMKV-----KGTIPWEFKSKFAARSY 61
           W+ ++  I  ++    +    +E F          M             +F      R++
Sbjct: 6   WIVIIVTIIHIILAPGT--KVEESFNV--QATHDLMFHLPTNLSNYDHSQF-PGVVPRTF 60

Query: 62  GPLL---LVYGPLFTILESFPEIQDNPALILYSMRLQNYVMYLLCYHFLIPKLIRDERKA 118
              +   ++  P+  I   +   +    L++   R    +M  + + +    + R   + 
Sbjct: 61  IGPISLAILSSPMSFIFRFWAIPKMWQLLLI---RATLGLMNAMAFLYFARSVNRKFGRE 117

Query: 119 VQFMQKSLLLTSYVTWTYQTHTFSNSIETLALISTLTVMEDMVNEKNIQRSNFKNSVILG 178
                + ++ T +    Y +    N+   + ++     + +   E  +       SVIL 
Sbjct: 118 TAMYLRLIMCTQFHYIFYMSRPLPNTFALILVMIVFERLLEGRYESAV--RYATASVIL- 174

Query: 179 LIFSFGVFNRVTFPAFIFLPCLILFWKFYRVHWKSFSLLLLSFSFSSCLFVLIDTNIYNN 238
               F     + +        +    K +       ++ +   +    + + ID+  +  
Sbjct: 175 ----FRCELVLLYGPIFLGYMISGRLKVFGFDGAI-AIGVRIAAMCLAVSIPIDSYFW-- 227

Query: 239 GKGFVITPLNNLKYNLNVQNLQVHGLHPRYTHLLVNLPQI--VGPVLLLAIFSGYKLDKL 296
               +      + +N+       +G  P   +    LP+      +L+       +    
Sbjct: 228 -GRPLWPEGEVMFFNVVENRSHEYGTQPFLWYFYSALPRCLLTTTLLVPLGLLVDRRLPQ 286

Query: 297 STYAIISGLLFLSFFQHQELRFLVPLVPLLVTNLNWTPLSSTLVNKKIFKGTWLLFNIIM 356
                +  +   SF  H+ELRF++ ++P+   +         +   K F    L F +I+
Sbjct: 287 IVLPSVIFIFLYSFLPHKELRFIIYVLPIFCLSAAVFCARMLINRHKSFFRMILFFGVIL 346

Query: 357 AFI 359
             +
Sbjct: 347 HLL 349
>ref|NP_014180.1| (NC_001146) catalyzes the transfer of mannose from Dol-P-Man to
           lipid-linked oligosaccharides; Alg9p [Saccharomyces
           cerevisiae]
 sp|P53868|ALG9_YEAST Probable mannosyltransferase ALG9
 pir||S63177 mannosyl transferase (EC 2.4.1.-) - yeast (Saccharomyces
           cerevisiae)
 emb|CAA96122.1| (Z71495) ORF YNL219c [Saccharomyces cerevisiae]
 emb|CAA65277.1| (X96417) putative mannosyltransferase [Saccharomyces cerevisiae]
          Length = 555

 Score =  233 bits (590), Expect = 5e-60
 Identities = 60/342 (17%), Positives = 116/342 (33%), Gaps = 29/342 (8%)

Query: 9   YLVYAIGLMLCLGPSYI--------HPDEHFQCIEILAMQFMKVKGTIPWEFKSKFAARS 60
            +  ++ L+L L   YI          DE F   E L    ++  G   WE+  +++ RS
Sbjct: 5   AVTISLLLLLFLTRVYIQPTFSLISDCDETFNYWEPL-NLLVRGFGKQTWEYSPEYSIRS 63

Query: 61  YGPLLLVYGPLFTILESFPEIQD-NPALILYSMRLQNYVMYLLCYHFLIPKLIRDERKAV 119
           +  LL    P + IL    +  D       +  R        +    L  ++       +
Sbjct: 64  WAFLL----PFYCILYPVNKFTDLESHWNFFITRACLGFFSFIMEFKLHREIAGSLALQI 119

Query: 120 QFMQKSLLLTSYVTWTYQTHTFSNSIETLALISTLTVMEDMVNEKNIQRSNFKNSVILGL 179
             +     L +   +        +++  L  +         ++  +   SNF  S+    
Sbjct: 120 ANIWIIFQLFNPGWFHASVELLPSAVAMLLYVGATRHSLRYLSTGST--SNFTKSLAYNF 177

Query: 180 IFSFGVFNRVTFPAFIFLPCLILFWKFYRVHWKSFSLL--LLSFSFSSCLFVLIDTNIYN 237
                      F   + LP  + +   +R+     +     L FS ++   ++ D+  Y 
Sbjct: 178 ---LASILGWPFVLILSLPLCLHYLFNHRIISTIRTAFDCCLIFSLTAFAVIVTDSIFY- 233

Query: 238 NGKGFVITPLNNLKYNLN----VQNLQVHGLHPRYTHLLVNLPQIVGPVLLLAIFSGYK- 292
                     N L YN+          + G+ P Y + L  L     PVL+LAI   +  
Sbjct: 234 --GKLAPVSWNILFYNVINASEESGPNIFGVEPWYYYPLNLLLNFPLPVLVLAILGIFHL 291

Query: 293 LDKLSTYAIISGLLFLSFFQHQELRFLVPLVPLLVTNLNWTP 334
                  ++ + +   +   H+E RFL P+  L+  + +   
Sbjct: 292 RLWPLWASLFTWIAVFTQQPHKEERFLYPIYGLITLSASIAF 333
 Score =  233 bits (590), Expect = 5e-60
 Identities = 60/342 (17%), Positives = 116/342 (33%), Gaps = 29/342 (8%)

Query: 9   YLVYAIGLMLCLGPSYI--------HPDEHFQCIEILAMQFMKVKGTIPWEFKSKFAARS 60
            +  ++ L+L L   YI          DE F   E L    ++  G   WE+  +++ RS
Sbjct: 5   AVTISLLLLLFLTRVYIQPTFSLISDCDETFNYWEPL-NLLVRGFGKQTWEYSPEYSIRS 63

Query: 61  YGPLLLVYGPLFTILESFPEIQD-NPALILYSMRLQNYVMYLLCYHFLIPKLIRDERKAV 119
           +  LL    P + IL    +  D       +  R        +    L  ++       +
Sbjct: 64  WAFLL----PFYCILYPVNKFTDLESHWNFFITRACLGFFSFIMEFKLHREIAGSLALQI 119

Query: 120 QFMQKSLLLTSYVTWTYQTHTFSNSIETLALISTLTVMEDMVNEKNIQRSNFKNSVILGL 179
             +     L +   +        +++  L  +         ++  +   SNF  S+    
Sbjct: 120 ANIWIIFQLFNPGWFHASVELLPSAVAMLLYVGATRHSLRYLSTGST--SNFTKSLAYNF 177

Query: 180 IFSFGVFNRVTFPAFIFLPCLILFWKFYRVHWKSFSLL--LLSFSFSSCLFVLIDTNIYN 237
                      F   + LP  + +   +R+     +     L FS ++   ++ D+  Y 
Sbjct: 178 ---LASILGWPFVLILSLPLCLHYLFNHRIISTIRTAFDCCLIFSLTAFAVIVTDSIFY- 233

Query: 238 NGKGFVITPLNNLKYNLN----VQNLQVHGLHPRYTHLLVNLPQIVGPVLLLAIFSGYK- 292
                     N L YN+          + G+ P Y + L  L     PVL+LAI   +  
Sbjct: 234 --GKLAPVSWNILFYNVINASEESGPNIFGVEPWYYYPLNLLLNFPLPVLVLAILGIFHL 291

Query: 293 LDKLSTYAIISGLLFLSFFQHQELRFLVPLVPLLVTNLNWTP 334
                  ++ + +   +   H+E RFL P+  L+  + +   
Sbjct: 292 RLWPLWASLFTWIAVFTQQPHKEERFLYPIYGLITLSASIAF 333
>gb|AAF99843.1|AC051629_10 (AC051629) Hypothetical protein [Arabidopsis thaliana]
          Length = 570

 Score =  230 bits (582), Expect = 5e-59
 Identities = 63/342 (18%), Positives = 118/342 (34%), Gaps = 33/342 (9%)

Query: 4   YQWWL-YLVYAIGLMLCLGPSYIH-PDEHFQCIEILAMQFMKVKGTIPWEFKSKFAARSY 61
            +W+L ++       +    + IH  DE F   E L    +   G   WE+ S FA RSY
Sbjct: 44  LRWFLPFIALCYLRYMSATSNIIHDCDEVFNYWEPL-HYILYKSGFQTWEYSSNFALRSY 102

Query: 62  GPLLLVYGPLFTILESFPEIQDNPALILYSMRLQNYVMYLLCYHFLIPKLIRDERKAVQF 121
               +++  L     S+    D+   + Y++RL   ++  +    L+  L R   K +  
Sbjct: 103 LY--ILFHELAGRPASWW-FGDDKVRVFYAVRLFLGLVSAVSDTVLVVALSRKYGKRIAT 159

Query: 122 MQKSLLLTSYVTWTYQTHTFSNSIETLALISTLTVMEDMVNEKNIQRSNFKNSVILGLIF 181
              ++L  +   +   T    +S    A+  +  ++                  +   + 
Sbjct: 160 YAVAMLCLTSGCFFASTSFLPSSFSMYAISLSSGLLLFEKYA------------MAVAVS 207

Query: 182 SFGVFNRVTFPAFIFLPCLILFWKFYRVHWKSFSLLLLSFSFSSCLFVLIDTNIYNNGKG 241
             GV     F    FLP +I         +K   +     +       L+    Y   K 
Sbjct: 208 VVGVILGWPFSILAFLPVVIYSLVKR---FKQAFIAGAVTTIFLLGVSLLVDYYY--YKR 262

Query: 242 FVITPLNNLKYNLNVQN-LQVHGLHPRYTHL--------LVNLPQIVGPVLLLAIFSGYK 292
           +  + LN L YN+       ++G      ++           +  ++   +   I   Y 
Sbjct: 263 WTSSVLNLLIYNVLGGGESHLYGTEGALFYIRNGFNNFNFCFILAMLFVAIYPVIRRKYD 322

Query: 293 LDKLSTY-AIISGLLFLSFFQHQELRFLVPLVPLLVTNLNWT 333
              L     +   L F+S   H+E RFL P+ PL+  + +  
Sbjct: 323 RALLVVISPMYIWLAFMSLQPHKEERFLYPIYPLICVSASAV 364
>pir||T28996 hypothetical protein ZC513.5 - Caenorhabditis elegans
          Length = 369

 Score =  229 bits (580), Expect = 7e-59
 Identities = 38/311 (12%), Positives = 101/311 (32%), Gaps = 19/311 (6%)

Query: 54  SKFAARSYGPLL---LVYGPLFTILESFPEIQDNPALILYSMRLQNYVMYLLCYHFLIPK 110
                R++   +   ++  P+  I   +   +    L++   R    +M  + + +    
Sbjct: 11  PGVVPRTFIGPISLAILSSPMSFIFRFWAIPKMWQLLLI---RATLGLMNAMAFLYFARS 67

Query: 111 LIRDERKAVQFMQKSLLLTSYVTWTYQTHTFSNSIETLALISTLTVMEDMVNEKNIQRSN 170
           + R   +      + ++ T +    Y +    N+   + ++     + +   E  +    
Sbjct: 68  VNRKFGRETAMYLRLIMCTQFHYIFYMSRPLPNTFALILVMIVFERLLEGRYESAV--RY 125

Query: 171 FKNSVILGLIFSFGVFNRVTFPAFIFLPCLILFWKFYRVHWKSFSLLLLSFSFSSCLFVL 230
              SVIL     F     + +        +    K +       ++ +   +    + + 
Sbjct: 126 ATASVIL-----FRCELVLLYGPIFLGYMISGRLKVFGFDGAI-AIGVRIAAMCLAVSIP 179

Query: 231 IDTNIYNNGKGFVITPLNNLKYNLNVQNLQVHGLHPRYTHLLVNLPQI--VGPVLLLAIF 288
           ID+  +      +      + +N+       +G  P   +    LP+      +L+    
Sbjct: 180 IDSYFW---GRPLWPEGEVMFFNVVENRSHEYGTQPFLWYFYSALPRCLLTTTLLVPLGL 236

Query: 289 SGYKLDKLSTYAIISGLLFLSFFQHQELRFLVPLVPLLVTNLNWTPLSSTLVNKKIFKGT 348
              +         +  +   SF  H+ELRF++ ++P+   +         +   K F   
Sbjct: 237 LVDRRLPQIVLPSVIFIFLYSFLPHKELRFIIYVLPIFCLSAAVFCARMLINRHKSFFRM 296

Query: 349 WLLFNIIMAFI 359
            L F +I+  +
Sbjct: 297 ILFFGVILHLL 307
>gb|AAF47201.1| (AE003464) CG3419 gene product [Drosophila melanogaster]
          Length = 830

 Score =  229 bits (580), Expect = 8e-59
 Identities = 112/497 (22%), Positives = 181/497 (35%), Gaps = 123/497 (24%)

Query: 12  YAIGLMLCLGPS--YIHPDEHFQCIEILAMQFMKVKGTIPWEFKSKFAARSYGPLLLVYG 69
            A+ L+L   P   Y+HPDE FQ +E++     +++ T  WEF +    RS    +++  
Sbjct: 24  AAVRLLLVFVPQLGYVHPDEFFQSVEVMTGDHFRLEHTRTWEFNNSLPVRS----IVLPF 79

Query: 70  PLFTILESFPEIQDNPALILY------------SMRLQNYVMYLLCYHFLIPKLIRDERK 117
            L  I  SF E         +              RL   ++     + L   + R    
Sbjct: 80  ALLRIPWSFYEFVAECLKAWWQLELLGTYAYVVFPRLIYTLISFSNDYCLFR-ICRLYGL 138

Query: 118 AVQFMQKSLLL-TSYVTWTYQTHTFSNSIETLALIS-------------TLTVMEDMVNE 163
             +F  + L + +S++   + T TFSNS+E                   T+   ++ + E
Sbjct: 139 --RFEIRLLAMGSSWILLVFGTRTFSNSLEMAMCSWLLCLVSECMLRTNTVVYKKEFLEE 196

Query: 164 K------------------NIQRSNFKNSVILGLIFSFGVFNRVTFPAFIFLPCLILFWK 205
           K                  ++   N ++ + +  I   GVFNR TF  F     ++ FW 
Sbjct: 197 KYDKAESISERVRIWKLKNSLPAHNLQHLMAMSTICVAGVFNRPTFLLFG--APMVFFWL 254

Query: 206 FYR-----VHWKSFSLLLLSFSFS----SCLFVLIDTNIYNNGK------------GFVI 244
                   + ++ F+L +  F         LF+  D+  Y +               FV 
Sbjct: 255 LRGMGTRSITFRDFNLRIALFCLCALPALVLFIFCDSLYYQHLTLGELHMMHLSIDNFVF 314

Query: 245 TPLNNLKYNLNVQNLQVHGLHPRYTHLLVNLPQIVGPVLLLAIFSGYK------------ 292
           TP N +K NL+      HG+HP Y HL+VN+P +    L LA    +             
Sbjct: 315 TPWNFIKANLDSAQTASHGVHPCYVHLMVNMPMLFNV-LALASLGAFAQLLLRFFRAEYQ 373

Query: 293 -------LDKLSTYAIISGLLFLSFFQHQELRFLVPL-VPLLVTNLN------------- 331
                  +  L + AI   L FLS   HQE RFL+P+  PL++ +               
Sbjct: 374 VLPRFQSIVSLMSGAIFVPLFFLSLINHQEPRFLLPVTFPLILLHAPKLITGFSAKYPFQ 433

Query: 332 ---------WTPLSSTLVNKKIFKGTWLLFNIIMAFIMGISHQAGIIQFLGDYFHF---R 379
                    +  L S+  +       W + N+ +    G  HQAG+     D  H    +
Sbjct: 434 KDHPLLRLFYDKLLSSKASGPYLLKIWYVSNVALTLFFGFIHQAGVYPLAADISHVIATK 493

Query: 380 TEQMGVHIWW-KTYSPP 395
                VH+     YS P
Sbjct: 494 PAATHVHLITSHIYSLP 510
>ref|NP_496282.1| (NM_063881) C14A4.3.p [Caenorhabditis elegans]
 sp|P54002|YTH3_CAEEL Hypothetical 75.5 kDa protein C14A4.3 in chromosome II
 pir||T19245 hypothetical protein C14A4.3 - Caenorhabditis elegans
 emb|CAA90107.1| (Z49909) weak similarity with a B. Flavum translocation protein
           (Swiss Prot accession number P38376)~cDNA EST yk549e12.3
           comes from this gene~cDNA EST yk618d6.3 comes from this
           gene~cDNA EST yk549e12.5 comes from this gene~cDNA EST
           yk618d6.5 comes from>
          Length = 653

 Score =  229 bits (579), Expect = 1e-58
 Identities = 57/344 (16%), Positives = 107/344 (30%), Gaps = 44/344 (12%)

Query: 7   WLYLVYAIGLMLCLGPSYIHPDEHFQCIEILAMQFMKVKGTIPWEFKSKFAARSYGPLLL 66
              ++ +I +   +       DE +   E L   F+  +G   WE+   +A RSY  + L
Sbjct: 56  VFKMLLSIRISGAIWGIINDCDEVYNYWEPL-HLFLYGEGFQTWEYSPVYAIRSYFYIYL 114

Query: 67  VYGPLFTILESFPEIQDNPALILYSMRLQNYVMYLLCYHFLIPKLIRDERKAVQFMQKSL 126
            Y P            D   ++   +RL   +  LL  ++    + +    A        
Sbjct: 115 HYIPASL---FANLFGDTKIVVFTLIRLTIGLFCLLGEYYAFDAICKKINIATGRFFILF 171

Query: 127 LLTSYVTWTYQTHTFSNSIETLALISTLTVMEDMVNEKNIQRSNFKNSVILGLIFSFGVF 186
            + S   +   T    +S        T  ++   +NE           V    +  +   
Sbjct: 172 SIFSSGMFLASTAFVPSSFCMA---ITFYILGAYLNENWTAG---IFCVAFSTMVGWPFS 225

Query: 187 NRVTFPAFIFLPCLILFWKFYRVHWKSFSLLLLSFSFSSCLFVLIDTNIYNNGKGFVITP 246
             +  P    +  L      +       + L++       + V+ D++ +      V+ P
Sbjct: 226 AVLGLPIVADMLLLKGLRIRF-----ILTSLVIGLCIG-GVQVITDSHYF---GKTVLAP 276

Query: 247 LNNLKYNLNVQ-NLQVHGLHPRYTHLLVNLPQIVGPVLLLAIFS---------------- 289
           LN   YN+       ++G  P   ++  NL      V+  A F                 
Sbjct: 277 LNIFLYNVVSGPGPSLYGEEPLSFYI-KNLFNNWNIVIFAAPFGFPLSLAYFTKVWMSQD 335

Query: 290 -------GYKLDKLSTYAIISGLLFLSFFQHQELRFLVPLVPLL 326
                   +    L      + LL      H+E RFL P+ P +
Sbjct: 336 RNVALYQRFAPIILLAVTTAAWLLIFGSQAHKEERFLFPIYPFI 379
>pir||T39659 cell wall biosynthesis protein N3265 homolog - fission yeast
           (Schizosaccharomyces pombe)
 emb|CAA21306.1| (AL031856) putative involvement in cell wall biogenesis and
           architecture [Schizosaccharomyces pombe]
          Length = 547

 Score =  214 bits (542), Expect = 3e-54
 Identities = 57/382 (14%), Positives = 115/382 (29%), Gaps = 46/382 (12%)

Query: 20  LGPSYIHPDEHFQCIEILAMQFMKVKGTIPWEFKSKFAARSYGPLLLVYGPLFTILESFP 79
                IH  + ++          KV   + +        RS+ P L +      +L   P
Sbjct: 36  FAMQAIHDIQTYRW------DLSKVYDHLEF---PGAVKRSFIPSLFIA-----VLSYIP 81

Query: 80  EIQDNPALILYSMRLQNYVMYLLCYHFLIPKLIRDERKAVQFMQKSLLLTSYVTWTYQTH 139
               NP L   + R     +     + +   + +        +        +    Y + 
Sbjct: 82  SWFVNPLL---AARWTIGYLSWESMNSVSCSISKRFGTLSGALFILFSCAQFHLVYYMSR 138

Query: 140 TFSNSIETLALISTLTVMEDMVNEKNIQRSNFKNSVILGLIFSFGVFNRVTFPAFIFLPC 199
             SN    +A   +L+++       +I             I  F      +  A + +  
Sbjct: 139 PLSNIFGLIATNHSLSLLLKNNYYGSIS------------ILVFAAAIVRSEIALLLMCL 186

Query: 200 LILFWKFYRVHWKSFSLLLLSFSFSSCLFVLIDTNIYNNGKGFVITPLNNLKYNLNVQNL 259
           ++      R+      L+ +S S ++     +  + +     +    L    +N+     
Sbjct: 187 ILPLLLQRRITLSKLLLVGISSSLAAVGASFLIDSYFW--GAWCWPELEAFLFNVVEGKS 244

Query: 260 QVHGLHPRYTHLLVNLPQIVGPVLLLAIFSGYKLDKLSTYAIISGLLF---LSFFQHQEL 316
              G  P Y + +      + P  LL +   +   K +   I   L F    SF  H+E 
Sbjct: 245 SDWGTSPFYYYFVRLPWLFLNPTTLLFLLISFVYIKPARLLIYVPLFFIFVYSFLGHKEW 304

Query: 317 RFLVPLVPLLVTNLNWT---PLSSTLVNKKIFKGTWLLFNIIMA---------FIMGISH 364
           RF++  +P              +++   KKIF+   L+F   +            +    
Sbjct: 305 RFIIYSIPWFNAASAIGASLCFNASKFGKKIFEILRLMFFSGIIFGFIGSSFLLYVFQYA 364

Query: 365 QAGIIQFLGDYFHFRTEQMGVH 386
             G +     Y      Q+ VH
Sbjct: 365 YPGGLALTRLYEIENHPQVSVH 386
>ref|NP_014427.1| (NC_001146) ExtraCellular Mutant; Ecm39p [Saccharomyces cerevisiae]
 sp|P53730|YN8I_YEAST Hypothetical 62.7 kDa protein in SEC12-SSK2 intergenic region
 pir||S63361 probable membrane protein YNR030w - yeast (Saccharomyces
           cerevisiae)
 emb|CAA96310.1| (Z71645) ORF YNR030w [Saccharomyces cerevisiae]
          Length = 551

 Score =  202 bits (510), Expect = 1e-50
 Identities = 61/419 (14%), Positives = 124/419 (29%), Gaps = 77/419 (18%)

Query: 4   YQW-----WLYLVYAIGLMLC--------LGPSYIHPDEHFQCIEILAMQFMKVKGTIPW 50
            +W      L  V +  L+               IH    +   +I     +K       
Sbjct: 1   MRWSVLDTVLLTVISFHLIQAPFTKVEESFNIQAIHDILTYSVFDISQYDHLKF------ 54

Query: 51  EFKSKFAARSYGPLLLVYG---PLFTILESFPEIQDNPALILYSMRLQNYVMYLLCYHFL 107
                   R++   +++     P   +       +     +   +R    +   L + +L
Sbjct: 55  ---PGVVPRTFVGAVIIAMLSRPYLYLSSLIQTSRPTSIDVQLVVRGIVGLTNGLSFIYL 111

Query: 108 IPKLIRDE------------------RKAVQFMQKSLLLTSYVTWTYQTHTFSNSIETLA 149
              L                        +        L+ S+    Y T T  N      
Sbjct: 112 KNCLQDMFDEITEKKKEENEDKDIYIYDSAGTWFLLFLIGSFHLMFYSTRTLPN------ 165

Query: 150 LISTLTVMEDMVNEKNIQRSNFKNSVILGLIFSFGVFNRVTFPAFIFLPCLILFWKFYRV 209
            + TL +    +    + R N    + L  + +      V+  +       +    F ++
Sbjct: 166 FVMTLPLTNVALGWVLLGRYNAA--IFLSALVAIVFRLEVSALSAGI---ALFSVIFKKI 220

Query: 210 HWKS-FSLLLLSFSFSSCLFVLIDTNIYNNGKGFVITPLNNLKYNLNVQNLQVHGLHPRY 268
                    +      S + + +D+  +     + +  ++   +N+        G+ P  
Sbjct: 221 SLFDAIKFGIFGLGLGSAISITVDSYFWQE---WCLPEVDGFLFNVVAGYASKWGVEPVT 277

Query: 269 THLLVNLPQIVGP--VLLLAIFS---GYKLDKLSTYAIISGLLFLSFFQHQELRFLVPLV 323
            +    L  +  P  VLLL  F         K+ + A +  ++ LSF  H+E RF++  V
Sbjct: 278 AYFTHYLRMMFMPPTVLLLNYFGYKLAPAKLKIVSLASLFHIIVLSFQPHKEWRFIIYAV 337

Query: 324 PLLVTNLNWTPLSSTLVNKKIFKGTWLL------------FNIIMA-FIMGISHQAGII 369
           P ++     T  +    N K+ K T +L            F I MA   +   +  G  
Sbjct: 338 PSIMLL-GATGAAHLWENMKVKKITNVLCLAILPLSIMTSFFISMAFLYISRMNYPGGE 395
>ref|XP_016392.3| (XM_016392) hypothetical protein FLJ12768 [Homo sapiens]
          Length = 457

 Score =  201 bits (507), Expect = 3e-50
 Identities = 94/335 (28%), Positives = 134/335 (39%), Gaps = 62/335 (18%)

Query: 109 PKLIRDERKAVQFMQKSLLLTSYVTWTYQTHTFSNSIETLALISTLTVMEDMVNEKNIQR 168
           P +  D          +LL  SYVT  + T TFSN+IE L     L ++   V     ++
Sbjct: 27  PAMGADRWN-----ALALLSGSYVTLVFYTRTFSNTIEGLLFTWLLVLVSSHVTWGPTRK 81

Query: 169 SNFKN----SVILGLIFSFGVFNRVTFPAFIFLPCLILFWKFYRVH---WKSFS----LL 217
                    S +LG I + G FNR TF AF  +P     W          KS +    +L
Sbjct: 82  EPAPGPRWRSWLLGGIVAAGFFNRPTFLAFAVVPL--YLWGTRGATNPGLKSLTREALVL 139

Query: 218 LLSFSFSSCLFVLIDTNIYNN---GKGFVITPLNNLKYNLNVQNLQVHGLHPRYTHLLVN 274
           L   + ++ +FV  D+  +++    +  V+TP+N L YNLN QNL  HG H R THL VN
Sbjct: 140 LPGATLTAAVFVATDSWYFSSPATSRNLVLTPVNFLHYNLNPQNLARHGTHARLTHLAVN 199

Query: 275 LPQIVGPVLLLAIFSGYKL--------------------------DKLSTYAIISGLLFL 308
              + G +   A+ + ++                                      L  L
Sbjct: 200 GFLLFGVLHAQALQAAWQRLQVGLQASAQMGLLRALGARSLLSSPRSYLLLLYFMPLALL 259

Query: 309 SFFQHQELRFLVPLVPLLVTNLNWTPLSSTLVNKKIFKGTWLLFNIIMAFIMGISHQAGI 368
           S F HQE RFL+PL+  LV         S       +KGT  LFN + A + G  HQ G+
Sbjct: 260 SAFSHQEARFLIPLLVPLVLLC------SPQTQPVPWKGTVALFNALGALLFGCLHQGGL 313

Query: 369 IQFLGDYFHFRTEQMG--------VHIWWKTYSPP 395
           +  L +Y                   ++  TY PP
Sbjct: 314 VPGL-EYLEQVVHAPVLPSTPTHYTLLFTHTYMPP 347
>gb|AAD53921.1|AF179611_5 (AF179611) phosphatidylinositol glycan homolog [Zymomonas mobilis]
          Length = 509

 Score =  201 bits (507), Expect = 3e-50
 Identities = 47/328 (14%), Positives = 103/328 (31%), Gaps = 26/328 (7%)

Query: 9   YLVYAIGLMLCLGPSYIHPDEHFQCIEILAMQFMKVKGTIPWEFKSKFAARSYGPLLLVY 68
            L   + +       Y HPDE FQ +E  A +       IPWE++            ++ 
Sbjct: 28  LLALCLRMTAIFPIGYYHPDEIFQYLEQ-AHRLAFGYSVIPWEYRYGMRGGLVP---VLL 83

Query: 69  GPLFTILESFPEIQDNPALILYSMRLQNYVMYLLCYHFLIPKLIRDERKAVQFMQKSLLL 128
                +     +I +  + + + +      +  L   +   KL R        +   +  
Sbjct: 84  AAAMKM----GDIMNTQSFLYWVLPHAITALLSLGVIWSAYKLGRLHSFFTGCLAMFVAA 139

Query: 129 TSYVTWTYQTHTFSNSIETLALISTLTVMEDMVNEKNIQRSNFKNSVILGLIFSFGVFNR 188
           T Y    +  H  S S+   A +     +      +  ++S+   S  L  + +      
Sbjct: 140 TWYEIVLFAAHPLSESLSFAAFMPAAYYL----IAEEKKKSSLILSGFLMGLSAL----- 190

Query: 189 VTFPAFIFLPCLILFWKFY-RVHWKSFSLLLLSFSFSSCLFVLIDTNIYNNGKGFVITPL 247
                F ++P ++    F  R++ + +   +L     +     +            +   
Sbjct: 191 ---LRFQYIPSILFITLFTLRINVRQWGYFILG-GLGAVFISSLSDIFIGEYPLLWL--F 244

Query: 248 NNLKYNLNVQNLQVHGLHPRYTHLLVNL--PQIVGPVLLLAIFSGYKLDKLSTYAIISGL 305
            N++ NL     + +G  P Y++        +    +L + I              +  L
Sbjct: 245 KNIQQNLIFHRAEDYGTAPIYSYFFDIWTNWKWFSLILPIPILVAAYRYPALFGTALVNL 304

Query: 306 LFLSFFQHQELRFLVPLVPLLVTNLNWT 333
           +F     H+E RF+     + +      
Sbjct: 305 IFHMLVSHKEYRFIFLSSGIFIILAAIG 332
>emb|CAC02000.2| (AL390114) possible hypothetical 66.3 Kd protein c1834.05 in
           chromosome I precursor [Leishmania major]
          Length = 822

 Score =  173 bits (437), Expect = 4e-42
 Identities = 48/354 (13%), Positives = 92/354 (25%), Gaps = 67/354 (18%)

Query: 7   WLYLVYAIGLMLCLGPSYIHPDEHFQCIEILAMQFMKVKGTIPWEFKSKFAARSYGPLLL 66
           +L L           P     DE F  IE +    +   G   WE  S+FA RS+  L +
Sbjct: 15  FLLLSLTHYFASSFLP-ISDCDETFNFIEPI-HYLLYGSGKQTWEVCSRFALRSWLFLWI 72

Query: 67  VYGPLFTILESFPEIQDNPALILYSMRLQNYVMYLLCYHFLIPKLIRDERKAVQFMQKSL 126
              P+  I  +      +   + + +R+ N     L   F +  +          +   L
Sbjct: 73  HAWPVVLIRGAASL---SSVRVYFYLRMLNGCAAALAELFFVCSVWFTLSGKAAAVALLL 129

Query: 127 LLTSYVTWTYQTHTFSNSIETLALISTLTVMEDMVNEKN-------IQRSNFKNSVILGL 179
           LL +Y            S   +     L       +  +       +     +N++    
Sbjct: 130 LLANYPIQHAAVSVLPTSFAMMCNFVVLGSWLRTQSWTSSSALLSRVGDRPTQNTMPAAA 189

Query: 180 I--------------------------------------------FSFGVFNRVTFPAFI 195
                                                            V     F A +
Sbjct: 190 AGTAQLSMMVPPSPSSAPTLHSSSASPPSAPPRHLCWFIGAALCFSVLAVVTGWPF-AAL 248

Query: 196 FLPCLILFWKFYRVHWKSFSLLLLSFSFSSCLFVLIDTNIYNNGKGFVITPLNNLKYNLN 255
               + L         ++ +  L      +C  V +    Y     + ++  N + YN  
Sbjct: 249 ISALVGLDLLLR-FPVRTLACTL-GSLLVACAAVFVADVRY--YCRWTLSSWNVVMYNGF 304

Query: 256 VQ---NLQVHGLHPRYTH---LLVNLPQIVGPVLLLAIFSGYKLDKLSTYAIIS 303
                  ++ G+ P +     L++N   +   VLL  +       +        
Sbjct: 305 GGSGRGPELFGVEPIFFFWKNLMLNFHLMFVVVLLAPVVLLCAPRRELAATSAL 358
 Score = 41.9 bits (98), Expect = 0.025
 Identities = 9/35 (25%), Positives = 13/35 (36%)

Query: 300 AIISGLLFLSFFQHQELRFLVPLVPLLVTNLNWTP 334
                 LF     H+E RF+ P  P ++     T 
Sbjct: 441 PFFVWFLFWMSIAHKEERFMSPAYPFMLLAATRTL 475
>dbj|BAB21931.1| (AB055306) hypothetical protein [Macaca fascicularis]
          Length = 198

 Score =  148 bits (371), Expect = 3e-34
 Identities = 27/131 (20%), Positives = 46/131 (34%), Gaps = 4/131 (3%)

Query: 8   LYLVYAIGLMLCLGPSYIHPDEHFQCIEILAMQFMKVKGTIPWEFKSKFAARSYGPLLLV 67
              + +  L   L  +    DE F   E      +  +G   WE+   +A RSY  LLL 
Sbjct: 62  FKCLLSARLCAALLSNISDCDETFNYWEP-THYLIYGEGFQTWEYSPAYAIRSYAYLLLH 120

Query: 68  YGPLFTILESFPEIQDNPALILYSMRLQNYVMYLLCYHFLIPKLIRDERKAVQFMQKSLL 127
             P          +Q N  L+ Y +R     +  +C  +    + +     V  M  + L
Sbjct: 121 AWPAAFHAR---ILQTNKILVFYFLRCLLAFVSCICELYFYKAVCKKFGLHVSRMMLAFL 177

Query: 128 LTSYVTWTYQT 138
           + S   +   +
Sbjct: 178 VLSTGMFCSSS 188
>gb|AAH21379.1|AAH21379 (BC021379) Similar to hypothetical protein MGC3136 [Mus musculus]
          Length = 385

 Score =  134 bits (336), Expect = 3e-30
 Identities = 33/227 (14%), Positives = 60/227 (25%), Gaps = 27/227 (11%)

Query: 7   WLYLVYAIGLMLCLGPSYIHPDEHFQCIEILAMQFMKVK----GTIPWEFKSKFAARSYG 62
            L  V  I L++C    Y   +E F          +  +         EF      R++ 
Sbjct: 17  LLVTVATIHLVIC---PYTKVEESFNL--QATHDLLYHQLDIDKYDHHEF-PGVVPRTFL 70

Query: 63  PLLLVYG---PLFTILESFPEIQDNPALILYSMRLQNYVMYLLCYHFLIPKLIRDERKAV 119
             L++     P+  +L      +    LI   +R    +  +     L  ++ +     V
Sbjct: 71  GPLVIAAFSSPVVYVLSLLEVSKFYSQLI---VRGVLGLGVISGLWTLQKEVRQQFGATV 127

Query: 120 QFMQKSLLLTSYVTWTYQTHTFSNSIETLALISTLTVMEDMVNEKNIQRSNFKNSVILGL 179
             M   +  T +    Y T T  N +    ++  LT           QR        L  
Sbjct: 128 AVMFCWISATQFHLMFYCTRTLPNVLALAVVLPALTAWL--------QRRWALFVW-LSA 178

Query: 180 IFSFGVFNRVTFPAFIFLPCLILFWKFYRVHWKSFSLLLLSFSFSSC 226
               G    +     I L   +   +           +         
Sbjct: 179 FVIIGFRAELAMLLGIALLLTLYQRRLTVARV-LRHAIPAGL-LCLG 223
 Score = 44.3 bits (104), Expect = 0.006
 Identities = 15/151 (9%), Positives = 40/151 (25%), Gaps = 36/151 (23%)

Query: 269 THLLVNLPQIVGPVLLLAIFSGYKLDKLSTYAIISGLLFLSFFQHQEL------------ 316
            +    LP ++   ++L   + +   +   +A+   L        +              
Sbjct: 143 FYCTRTLPNVLALAVVLPALTAWLQRR---WALFVWLSAFVIIGFRAELAMLLGIALLLT 199

Query: 317 ---------RFLVPLVP--LLVT--NLNWTPLSSTLVNKKIFKGTWLLFNIIM------- 356
                    R L   +P  LL      +   L +        +   +  +I++       
Sbjct: 200 LYQRRLTVARVLRHAIPAGLLCLGKLASLVCLLNKKSWPYKVRAMLVTGHILVNVAYTAT 259

Query: 357 AFIMGISHQAGIIQFLGDYFHFRTEQMGVHI 387
           +  +   +  G +  +         Q  V +
Sbjct: 260 SLYVSHFNYPGGV-AMQQLHELVPPQTDVLL 289
>dbj|BAA87150.1| (AB027846) Hypothetical protein [Schizosaccharomyces pombe]
          Length = 197

 Score =  130 bits (326), Expect = 5e-29
 Identities = 31/211 (14%), Positives = 66/211 (30%), Gaps = 17/211 (8%)

Query: 116 RKAVQFMQKSLLLTSYVTWTYQTHTFSNSIETLALISTLTVMEDMVNEKNIQRSNFKNSV 175
                 +        +    Y +   SN    +A   +L+++       +I         
Sbjct: 1   GTLSGALFILFSCAQFHLVYYMSRPLSNIFGLIATNHSLSLLLKNNYYGSIS-------- 52

Query: 176 ILGLIFSFGVFNRVTFPAFIFLPCLILFWKFYRVHWKSFSLLLLSFSFSSCLFVLIDTNI 235
               I  F      +  A + +  ++      R+      L+ +S S ++     +  + 
Sbjct: 53  ----ILVFAAAIVRSEIALLLMCLILPLLLQRRITLSKLLLVGISSSLAAVGASFLIDSY 108

Query: 236 YNNGKGFVITPLNNLKYNLNVQNLQVHGLHPRYTHLLVNLPQIVGPVLLLAIFSGYKLDK 295
           +     +    L    +N+        G  P Y + +      + P  LL +   +   K
Sbjct: 109 FW--GAWCWPELEAFLFNVVEGKSSDWGTSPFYYYFVRLPWLFLNPTTLLFLLISFVYIK 166

Query: 296 LSTYAIISGLLF---LSFFQHQELRFLVPLV 323
            +   I   L F    SF  H+E RF++  +
Sbjct: 167 PARLLIYVPLFFIFVYSFLGHKEWRFIIYSI 197
>pir||T16945 hypothetical protein T27F7.3 - Caenorhabditis elegans
          Length = 283

 Score =  128 bits (319), Expect = 3e-28
 Identities = 27/133 (20%), Positives = 53/133 (39%), Gaps = 10/133 (7%)

Query: 252 YNLNVQNLQVHGLHPRYTHLLVNLPQIVGPVLLLAI--FSGYKLDKLSTYAIISG---LL 306
           +N+      + G+HP Y +++  +P ++   ++  I    G  + + S     +    ++
Sbjct: 131 FNVVQGGSALFGVHPWYWYIVSGIPAVLTVQMIPIIVGLLGPNIFRPSLLPFFATITYII 190

Query: 307 FLSFFQHQELRFLVPLVPLLVTNLNWTPLSSTLVNKKIFKGTWLLFNIIMAFIMGISHQ- 365
             S   H+E RFL+P++PLL          +    +       +  NI +A      HQ 
Sbjct: 191 VHSLLPHKEQRFLLPIIPLLCIYAG-GAFQNLKKWRGSAMAVMIAINIGIALFTSRYHQK 249

Query: 366 ---AGIIQFLGDY 375
               G I    +Y
Sbjct: 250 HSCNGTIVEHPEY 262
 Score = 68.4 bits (166), Expect = 3e-10
 Identities = 18/73 (24%), Positives = 33/73 (44%), Gaps = 7/73 (9%)

Query: 1   MMRYQWWLYLVYAIGLMLC----LGPSYIHPDEHFQCIEILAMQFMKVKGTIPWEFKSKF 56
           ++R +  L L+  + +  C    L  S+  PDE +Q  E+ A   +   G + WE++   
Sbjct: 62  VLRMRTTLRLLAKLVVFRCISVYLVASWFVPDEVYQSAEV-AHHLVYGTGHLSWEWRHSL 120

Query: 57  AARSYGPLLLVYG 69
             RS+    L+  
Sbjct: 121 --RSFFHPALIAF 131
>emb|CAA42931.1| (X60381) ORF2 [Saccharomyces cerevisiae]
          Length = 278

 Score =  123 bits (308), Expect = 7e-27
 Identities = 27/134 (20%), Positives = 49/134 (36%), Gaps = 11/134 (8%)

Query: 279 VGPVLLLAIFSGYKLDK----LSTYAIISGLLFLSFFQHQELRFLVPLVPLLVTNLNWTP 334
            G    L+  S  K            I+  LL  S   H+E RF+ PL PL +   ++  
Sbjct: 15  FGLFFPLSKRSFPKKYLNPFFQVKLTILLNLLVYSTLPHKEFRFIFPLQPLFILISSFGL 74

Query: 335 LS-----STLVNK-KIFKGTWLLFNIIMAFIMGISHQAGIIQFLGDYFHFRTEQMGVHIW 388
           L         ++  K         ++ +A ++   H++G I+ +  + H   E   +   
Sbjct: 75  LRLDRDYWKRLSGLKSLLWLVPFVSVFIALLLDTFHESGSIEVM-KFLHEEPEIDSLGFI 133

Query: 389 WKTYSPPTWMYMSN 402
              +S P   Y+  
Sbjct: 134 MPCHSTPGQSYLHR 147
>ref|NP_494918.1| (NM_062517) T27F7.3a.p [Caenorhabditis elegans]
 gb|AAK39304.1| (U58762) weakly similar to protein translation factor SUI1 family
           [Caenorhabditis elegans]
          Length = 232

 Score =  121 bits (303), Expect = 2e-26
 Identities = 27/133 (20%), Positives = 53/133 (39%), Gaps = 10/133 (7%)

Query: 252 YNLNVQNLQVHGLHPRYTHLLVNLPQIVGPVLLLAI--FSGYKLDKLSTYAIISG---LL 306
           +N+      + G+HP Y +++  +P ++   ++  I    G  + + S     +    ++
Sbjct: 67  FNVVQGGSALFGVHPWYWYIVSGIPAVLTVQMIPIIVGLLGPNIFRPSLLPFFATITYII 126

Query: 307 FLSFFQHQELRFLVPLVPLLVTNLNWTPLSSTLVNKKIFKGTWLLFNIIMAFIMGISHQ- 365
             S   H+E RFL+P++PLL          +    +       +  NI +A      HQ 
Sbjct: 127 VHSLLPHKEQRFLLPIIPLLCIYAG-GAFQNLKKWRGSAMAVMIAINIGIALFTSRYHQK 185

Query: 366 ---AGIIQFLGDY 375
               G I    +Y
Sbjct: 186 HSCNGTIVEHPEY 198
 Score = 61.4 bits (148), Expect = 3e-08
 Identities = 17/70 (24%), Positives = 30/70 (42%), Gaps = 7/70 (10%)

Query: 4  YQWWLYLVYAIGLMLC----LGPSYIHPDEHFQCIEILAMQFMKVKGTIPWEFKSKFAAR 59
           +  L L+  + +  C    L  S+  PDE +Q  E+ A   +   G + WE++     R
Sbjct: 1  MRTTLRLLAKLVVFRCISVYLVASWFVPDEVYQSAEV-AHHLVYGTGHLSWEWRHSL--R 57

Query: 60 SYGPLLLVYG 69
          S+    L+  
Sbjct: 58 SFFHPALIAF 67
>ref|NP_440407.1| (NC_000911) unknown protein [Synechocystis sp. PCC 6803]
 pir||S75173 hypothetical protein sll1946 - Synechocystis sp. (strain PCC 6803)
 dbj|BAA17087.1| (D90903) ORF_ID:sll1946~unknown protein [Synechocystis sp. PCC
           6803]
          Length = 825

 Score = 44.6 bits (105), Expect = 0.004
 Identities = 40/392 (10%), Positives = 104/392 (26%), Gaps = 66/392 (16%)

Query: 10  LVYAIGLMLCLGPSYIHPDEHFQCIEILAMQFMKVKGTIPWEFKSKFAARSYGPLLLVYG 69
           L Y +  +  L        E ++                 W    K+   +Y    +V  
Sbjct: 46  LSYGLEYLQALRSPEFLSGEWWRSF---------------WMLSPKYPPLTY----IVNA 86

Query: 70  PLFTILESFPEIQDNPALILYSMRLQNYVMYLLCYHFLIPKLIRDERKAVQFMQKSLLLT 129
           P   +     ++      +             +    +     +   + +     ++++ 
Sbjct: 87  PFQGLGGPGSDLALLSNWLW----------SGILILSVYGLGKKLFSREIGLWAVAIMVL 136

Query: 130 SYVTWTYQTHTFSNSIETLALISTLTVMEDMVNEKNIQRSNFKNSVILGLIFSFGVFNRV 189
                  +       +++  L  TL     +   K  +    +    +      G+    
Sbjct: 137 IPRLIHSRLIVL---LDSPLLAFTLLSFTCLTYWKEAEGRRSQWLWAIAAGVGLGLGLLS 193

Query: 190 TFPAFIFLPCLILFWKFYRVHWKSFSLLLLSFSFSSCLFVLIDTNIYNNGKGFVITPLNN 249
                 +L   ++    + +  K +   L          + +          ++      
Sbjct: 194 KQSIIFYLFFPLVGLGLWSIWTKQWQ-RLAQLLVGLLASIPL--WYPWYRTNWIYLFSTA 250

Query: 250 LKYNLNVQNLQVHGLHPR-----YTHLLVNLPQIV-GPVLLLAIFSGYK----------- 292
              N N     + G  P      +T+   +LP  +    L+  +                
Sbjct: 251 --QNSNAIPATLEGDPPVNTLAAWTYYWQDLPNALSWVWLIPPLVGVILSLLNRFPASLQ 308

Query: 293 -LDKLSTYAIISGLLFL--------SFFQHQELRFLVPLVPLLVTNLNWTPLSSTLVNKK 343
                     +  L +         S  Q+++ R+++P +P++   L +           
Sbjct: 309 IPSWREAKPGLLWLGYYYGGTYLICSAIQNKDDRYILPYLPIVAIFLAFGLTRWCGRWLW 368

Query: 344 IFKGTWLLFNIIMAF--IMGISHQAGIIQFLG 373
           +  GT  +  I++    +  I    GI+Q L 
Sbjct: 369 VRWGTLAIT-ILITLGNLFPIPGSNGIVQALN 399
>ref|NP_488731.1| (NC_003272) unknown protein [Nostoc sp. PCC 7120]
 dbj|BAB76390.1| (AP003597) ORF_ID:alr4691~unknown protein [Nostoc sp. PCC 7120]
          Length = 541

 Score = 36.5 bits (84), Expect = 1.1
 Identities = 43/276 (15%), Positives = 83/276 (29%), Gaps = 20/276 (7%)

Query: 68  YGPLFTILESFPEIQDNPALILYSMRLQNYVMYLLCYHFLIPKLIRDERKAVQFMQKSLL 127
            GP + I   +     N     +S+RL + +  +LC  FL+ ++ +           + +
Sbjct: 76  PGPYWLIASFYQLFGVNE----FSVRLPSMIFGVLC-LFLVYEIGKIMLGKTLAWLSAAI 130

Query: 128 LTSYVTWTYQTHTFSNSIETLALISTLTVMEDMVNEKNIQRSNFKNSVILGLIFSFGVFN 187
           L+    W   +   +  +  + L+     +          R  F  S I+GL    G   
Sbjct: 131 LSVEFLWLQYSRLGNPDLPMIFLVLLAIYLLIQAELHPQYRDYF--SFIVGLSLGLGFLM 188

Query: 188 RVTFPAFI--FLPCLILFWKFYRVHWKSFSLLLLSFSFSSCLFVLIDTNIYNNGKGFVIT 245
           R +F  F+        L  +  R    +   L L         ++     +        T
Sbjct: 189 R-SFVIFLPTVALLPYLITEHRRHRHLTNPWLYLGVVIGFIPILIWSWFNWQRDGNNTFT 247

Query: 246 PLNNLKYNLNVQNLQVHGLHPRYTHLLVNLPQIV------GPVLLLAIFSGYKLDKLSTY 299
            L N    + +   +    +    +    L +           LLL I   +    L   
Sbjct: 248 HLVNF---VFLLGSEERDGNGILFYFWNTLLKAFPWPCFSLLGLLLIIRRPWHRYNLILI 304

Query: 300 AIISGLLF-LSFFQHQELRFLVPLVPLLVTNLNWTP 334
                LL  L+ F  +   + + L P +        
Sbjct: 305 GFPIVLLAELTIFSTRLSHYALSLYPFIALLAAVGL 340
>ref|NP_069450.1| (NC_000917) conserved hypothetical protein [Archaeoglobus fulgidus]
 pir||H69326 conserved hypothetical protein AF0616 - Archaeoglobus fulgidus
 gb|AAB90624.1| (AE001062) conserved hypothetical protein [Archaeoglobus fulgidus]
          Length = 533

 Score = 34.5 bits (79), Expect = 4.3
 Identities = 50/395 (12%), Positives = 118/395 (29%), Gaps = 63/395 (15%)

Query: 6   WWLYLVYAIGLMLCLGPSYIHPDEHFQCIEILAMQ---FMKVKGTIPWEFKSKFAARSYG 62
             L L+    ++      +I  D+  Q  +        F+        +F       +Y 
Sbjct: 12  LVLLLITTFVVIT--NVYFIAWDDSPQSWDPALHLTYSFVYFNLIKSLQFSEIVKVSNYY 69

Query: 63  PLLLVYG--PLFTILESFPEIQDNPALILYSMRLQNYVMYLLCYHFLIPKLIRDERKAVQ 120
           P        PL+ +     +I     LI Y               + + ++ +  +    
Sbjct: 70  PPFFYLSSTPLYFLFGFSEDIAILTNLIYYF-----------ILIYSVFQIAKIMKDRNA 118

Query: 121 FMQKSLLLTSYVTWTYQTHTFSNSIETLALISTLTVMEDMVNEKNIQRSNFKNSVILGLI 180
            +  +++++++         +      L    +LT    ++  ++    N K SV+ G++
Sbjct: 119 GVISAVIISAFPALIKFQRVYMIDFALL----SLTAFAILLYLRSEDFRNLKYSVLFGIV 174

Query: 181 FSFGVFNRVTF-----PAFIFLPCLILFWK---FYRVHWKSFSLLLLSFS---------- 222
           F      +        P+   L  +  F +    +++    + +    F           
Sbjct: 175 FGIAELTKWNAFVYIIPSIFALFLVNYFMRCPYCHQIVKNGWKVGYRRFCSKKHLKLYEK 234

Query: 223 ----------FSSCLFVLIDTNIYNNGKGFVITPLNNLKYNLNVQN---LQVHGLHPRYT 269
                     F+  LFV      +          +    +              +     
Sbjct: 235 SAKTNNTMLNFAISLFVAFLFAAWWYLPNLSTVIMRLTYFANIGGKEGDPAFLTIQGWIY 294

Query: 270 HLLVNLPQIVGPVLLLAIFSGYKLDKL-------STYAIISGLLFLSFFQHQELRFLVPL 322
           +    L  +    L+L   S Y L K            I    + L+   +++ R+++P+
Sbjct: 295 YANSILDAVGAVFLILFAVSIYYLYKNNRYLFLGLLTPIALIYIILTLLSNKDPRYIMPV 354

Query: 323 VPLLVTNLNWTPLSSTLVNKKI--FKGTWLLFNII 355
           +P +  ++    +SS    K         LLF ++
Sbjct: 355 LPFVAISIG-VFVSSLANRKYSTILTFIILLFGLL 388
CPU time:   154.34 user secs.	    3.99 sys. secs	  158.33 total secs.

  Database: nr
    Posted date:  Apr 21, 2002  2:19 PM
  Number of letters in database: 277,845,442
  Number of sequences in database:  887,402
  
Lambda     K      H
   0.317    0.178    0.501 

Gapped
Lambda     K      H
   0.270   0.0623    0.230 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 370388278
Number of Sequences: 887402
Number of extensions: 20624271
Number of successful extensions: 93214
Number of sequences better than 10.0: 935
Number of HSP's better than 10.0 without gapping: 62
Number of HSP's successfully gapped in prelim test: 895
Number of HSP's that attempted gapping in prelim test: 91872
Number of HSP's gapped (non-prelim): 1705
length of query: 516
length of database: 277,845,442
effective HSP length: 52
effective length of query: 464
effective length of database: 231,700,538
effective search space: 107509049632
effective search space used: 107509049632
T: 11
A: 40
X1: 15 ( 6.9 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 40 (20.8 bits)
S2: 76 (33.6 bits)