Sequences with E-value BETTER than threshold (0.002) 221 3e-57
221 5e-57
221 5e-57
219 2e-56
218 4e-56
174 7e-43
173 1e-42
170 9e-42
135 4e-31
133 2e-30
116 1e-25
109 2e-23
107 1e-22
Sequences with E-value WORSE than threshold ref|NP_010725.1| (NC_001136) Protein required for cell viability... 41 0.010
gb|AAF56563.1| (AE003754) CG14550 gene product [Drosophila melan... 38 0.072
Alignments
>sp|P57054|DSR5_HUMAN Down syndrome critical region protein 5 (Down syndrome critical
region protein C)
dbj|BAA96872.1| (AB037163) DSCR5b [Homo sapiens]
Length = 158
Score = 221 bits (559), Expect = 3e-57
Identities = 121/132 (91%), Positives = 127/132 (95%)
Query: 1 MVENSPSPLPERAIYGFVLFLSSQFGFILYLVWAFVPESWLNSLGLTYWPQKYWAVALPV 60
MVENSPSPLPERAIYGFVLFLSSQFGFILYLVWAF+PESWLNSLGLTYWPQKYWAVALPV
Sbjct: 25 MVENSPSPLPERAIYGFVLFLSSQFGFILYLVWAFIPESWLNSLGLTYWPQKYWAVALPV 84
Query: 61 YLLITVVIGYVLLFGINMMSTSPLDSIHTITDNYAKNQQRKNYQEDAIPALRDVPISEVN 120
YLLI +VIGYVLLFGINMMSTSPLDSIHTITDNYAKNQQ+K YQE+AIPALRD+ ISEVN
Sbjct: 85 YLLIAIVIGYVLLFGINMMSTSPLDSIHTITDNYAKNQQQKKYQEEAIPALRDISISEVN 144
Query: 121 KMFFLGAKELNT 132
+MFFL AKEL T
Sbjct: 145 QMFFLAAKELYT 156
>pir||JC7302 Down syndrome critical region protein 5 beta - human
Length = 158
Score = 221 bits (558), Expect = 5e-57
Identities = 120/132 (90%), Positives = 127/132 (95%)
Query: 1 MVENSPSPLPERAIYGFVLFLSSQFGFILYLVWAFVPESWLNSLGLTYWPQKYWAVALPV 60
MVENSPSPLPERAIYGFVLFLSSQFGFILYLVWAF+PESWLNSLGLTYWPQKYWAVALPV
Sbjct: 25 MVENSPSPLPERAIYGFVLFLSSQFGFILYLVWAFIPESWLNSLGLTYWPQKYWAVALPV 84
Query: 61 YLLITVVIGYVLLFGINMMSTSPLDSIHTITDNYAKNQQRKNYQEDAIPALRDVPISEVN 120
YLLI +VIGYVLLFG+NMMSTSPLDSIHTITDNYAKNQQ+K YQE+AIPALRD+ ISEVN
Sbjct: 85 YLLIAIVIGYVLLFGLNMMSTSPLDSIHTITDNYAKNQQQKKYQEEAIPALRDISISEVN 144
Query: 121 KMFFLGAKELNT 132
+MFFL AKEL T
Sbjct: 145 QMFFLAAKELYT 156
>dbj|BAA95636.1| (AB035745) DSCR5b [Homo sapiens]
gb|AAG09757.1|AF237812_1 (AF237812) NPD010 [Homo sapiens]
Length = 158
Score = 221 bits (558), Expect = 5e-57
Identities = 121/132 (91%), Positives = 127/132 (95%)
Query: 1 MVENSPSPLPERAIYGFVLFLSSQFGFILYLVWAFVPESWLNSLGLTYWPQKYWAVALPV 60
MVENSPSPLPERAIYGFVLFLSSQFGFILYLVWAF+PESWLNSLGLTYWPQKYWAVALPV
Sbjct: 25 MVENSPSPLPERAIYGFVLFLSSQFGFILYLVWAFIPESWLNSLGLTYWPQKYWAVALPV 84
Query: 61 YLLITVVIGYVLLFGINMMSTSPLDSIHTITDNYAKNQQRKNYQEDAIPALRDVPISEVN 120
YLLI +VIGYVLLFGINMMSTSPLDSIHTITDNYAKNQQ+K YQE+AIPALRD+ ISEVN
Sbjct: 85 YLLIAIVIGYVLLFGINMMSTSPLDSIHTITDNYAKNQQQKKYQEEAIPALRDISISEVN 144
Query: 121 KMFFLGAKELNT 132
+MFFL AKEL T
Sbjct: 145 QMFFLAAKELYT 156
>ref|NP_062416.1| (NM_019543) Down syndrome critical region protein c [Mus musculus]
gb|AAF32294.1|AF216306_1 (AF216306) DCRC-1 [Mus musculus]
gb|AAF32295.1|AF216307_1 (AF216307) DCRC-2 [Mus musculus]
gb|AAF32296.1|AF216308_1 (AF216308) DCRC-3 [Mus musculus]
gb|AAF32297.1|AF216309_1 (AF216309) DCRC-4 [Mus musculus]
dbj|BAB23204.1| (AK004169) Down syndrome critical region gene c~data source:MGD,
source key:MGI:1860433, evidence:ISS~putative [Mus
musculus]
Length = 132
Score = 219 bits (553), Expect = 2e-56
Identities = 132/132 (100%), Positives = 132/132 (100%)
Query: 1 MVENSPSPLPERAIYGFVLFLSSQFGFILYLVWAFVPESWLNSLGLTYWPQKYWAVALPV 60
MVENSPSPLPERAIYGFVLFLSSQFGFILYLVWAFVPESWLNSLGLTYWPQKYWAVALPV
Sbjct: 1 MVENSPSPLPERAIYGFVLFLSSQFGFILYLVWAFVPESWLNSLGLTYWPQKYWAVALPV 60
Query: 61 YLLITVVIGYVLLFGINMMSTSPLDSIHTITDNYAKNQQRKNYQEDAIPALRDVPISEVN 120
YLLITVVIGYVLLFGINMMSTSPLDSIHTITDNYAKNQQRKNYQEDAIPALRDVPISEVN
Sbjct: 61 YLLITVVIGYVLLFGINMMSTSPLDSIHTITDNYAKNQQRKNYQEDAIPALRDVPISEVN 120
Query: 121 KMFFLGAKELNT 132
KMFFLGAKELNT
Sbjct: 121 KMFFLGAKELNT 132
>pir||JC7301 Down syndrome critical region protein 5 alpha - human
dbj|BAA95633.1| (AB035742) DSCR5a1 [Homo sapiens]
dbj|BAA95634.1| (AB035743) DSCR5a2 [Homo sapiens]
dbj|BAA95635.1| (AB035744) DSCR5a3 [Homo sapiens]
dbj|BAA96871.1| (AB037162) DSCR5a [Homo sapiens]
dbj|BAB12395.1| (AB039659) PIG-P [Homo sapiens]
gb|AAH05180.1|AAH05180 (BC005180) Unknown (protein for MGC:12168) [Homo sapiens]
gb|AAH11007.1|AAH11007 (BC011007) Unknown (protein for MGC:13327) [Homo sapiens]
Length = 134
Score = 218 bits (550), Expect = 4e-56
Identities = 121/132 (91%), Positives = 127/132 (95%)
Query: 1 MVENSPSPLPERAIYGFVLFLSSQFGFILYLVWAFVPESWLNSLGLTYWPQKYWAVALPV 60
MVENSPSPLPERAIYGFVLFLSSQFGFILYLVWAF+PESWLNSLGLTYWPQKYWAVALPV
Sbjct: 1 MVENSPSPLPERAIYGFVLFLSSQFGFILYLVWAFIPESWLNSLGLTYWPQKYWAVALPV 60
Query: 61 YLLITVVIGYVLLFGINMMSTSPLDSIHTITDNYAKNQQRKNYQEDAIPALRDVPISEVN 120
YLLI +VIGYVLLFGINMMSTSPLDSIHTITDNYAKNQQ+K YQE+AIPALRD+ ISEVN
Sbjct: 61 YLLIAIVIGYVLLFGINMMSTSPLDSIHTITDNYAKNQQQKKYQEEAIPALRDISISEVN 120
Query: 121 KMFFLGAKELNT 132
+MFFL AKEL T
Sbjct: 121 QMFFLAAKELYT 132
>ref|NP_057514.1| (NM_016430) Down syndrome critical region protein 5; Down syndrome
critical region protein C short form; Down syndrome
critical region protein C [Homo sapiens]
gb|AAF32289.1|AF216305_1 (AF216305) Down syndrome critical region protein C short form [Homo
sapiens]
dbj|BAA96873.1| (AB037164) DSCR5c [Homo sapiens]
Length = 108
Score = 174 bits (437), Expect = 7e-43
Identities = 94/105 (89%), Positives = 100/105 (94%)
Query: 28 ILYLVWAFVPESWLNSLGLTYWPQKYWAVALPVYLLITVVIGYVLLFGINMMSTSPLDSI 87
+LYLVWAF+PESWLNSLGLTYWPQKYWAVALPVYLLI VVIGYVLLFGINMMSTSPLDSI
Sbjct: 2 VLYLVWAFIPESWLNSLGLTYWPQKYWAVALPVYLLIAVVIGYVLLFGINMMSTSPLDSI 61
Query: 88 HTITDNYAKNQQRKNYQEDAIPALRDVPISEVNKMFFLGAKELNT 132
HTITDNYAKNQQ+K YQE+AIPALRD+ ISEVN+MFFL AKEL T
Sbjct: 62 HTITDNYAKNQQQKKYQEEAIPALRDISISEVNQMFFLAAKELYT 106
>dbj|BAA95512.1| (AP001727) Down syndrome critical region protein C [Homo sapiens]
Length = 108
Score = 173 bits (436), Expect = 1e-42
Identities = 93/105 (88%), Positives = 100/105 (94%)
Query: 28 ILYLVWAFVPESWLNSLGLTYWPQKYWAVALPVYLLITVVIGYVLLFGINMMSTSPLDSI 87
+LYLVWAF+PESWLNSLGLTYWPQKYWAVALPVYLLI +VIGYVLLFGINMMSTSPLDSI
Sbjct: 2 VLYLVWAFIPESWLNSLGLTYWPQKYWAVALPVYLLIAIVIGYVLLFGINMMSTSPLDSI 61
Query: 88 HTITDNYAKNQQRKNYQEDAIPALRDVPISEVNKMFFLGAKELNT 132
HTITDNYAKNQQ+K YQE+AIPALRD+ ISEVN+MFFL AKEL T
Sbjct: 62 HTITDNYAKNQQQKKYQEEAIPALRDISISEVNQMFFLAAKELYT 106
>ref|NP_176323.1| (NM_104809) hypothetical protein [Arabidopsis thaliana]
sp|O64792|DSR5_ARATH Down syndrome critical region protein 5 homolog
gb|AAC13913.1|AAC13913 (AC004255) T1F9.23 [Arabidopsis thaliana]
Length = 137
Score = 170 bits (428), Expect = 9e-42
Identities = 40/119 (33%), Positives = 74/119 (61%), Gaps = 5/119 (4%)
Query: 11 ERAIYGFVLFLSSQFGFILYLVWAFVPESWLNSLGLTYWPQKYWAVALPVYLLITVVIGY 70
+YGFV +S +++L+W +VP+ +L S+G+ Y+P KYWA+A+P+Y ++T+++
Sbjct: 13 TSEVYGFVGSISIVVATVIFLIWGYVPDKFLESIGIYYYPSKYWAMAMPMYSMVTLLVAL 72
Query: 71 VLLFGINMMSTSPLDSIHTITDNYAKNQQR-----KNYQEDAIPALRDVPISEVNKMFF 124
V G+N MSTS S++T+ D+Y++ KN ++ I + D+ I+ +N + F
Sbjct: 73 VFYIGLNFMSTSKPTSLNTLFDDYSREDVNFLPLMKNGEDRPIDPISDIDITRINDLMF 131
>pir||T38153 hypothetical protein SPAC22A12.13 - fission yeast
(Schizosaccharomyces pombe)
Length = 157
Score = 135 bits (337), Expect = 4e-31
Identities = 32/88 (36%), Positives = 50/88 (56%), Gaps = 1/88 (1%)
Query: 9 LPERAIYGFVLFLSSQFGFILYLVWAFVPESWLNSLGLTYWPQKYWAVALPVYLLITVVI 68
+P YGFV++L S GF +Y+VWA P L + Y+ ++WA+A+P +L + V+
Sbjct: 41 VPTYEYYGFVMYLVSMLGFGVYIVWALTPAPVLKFFEIHYYLSRWWALAIPTWLFVLVIY 100
Query: 69 GYVLLFGINM-MSTSPLDSIHTITDNYA 95
+V+L N + T P S+ I D YA
Sbjct: 101 IHVVLNAYNTEVLTKPFSSLECIVDQYA 128
>emb|CAB16583.2| (Z99295) human downs syndrome critical region-like
[Schizosaccharomyces pombe]
Length = 120
Score = 133 bits (332), Expect = 2e-30
Identities = 32/88 (36%), Positives = 50/88 (56%), Gaps = 1/88 (1%)
Query: 9 LPERAIYGFVLFLSSQFGFILYLVWAFVPESWLNSLGLTYWPQKYWAVALPVYLLITVVI 68
+P YGFV++L S GF +Y+VWA P L + Y+ ++WA+A+P +L + V+
Sbjct: 4 VPTYEYYGFVMYLVSMLGFGVYIVWALTPAPVLKFFEIHYYLSRWWALAIPTWLFVLVIY 63
Query: 69 GYVLLFGINM-MSTSPLDSIHTITDNYA 95
+V+L N + T P S+ I D YA
Sbjct: 64 IHVVLNAYNTEVLTKPFSSLECIVDQYA 91
>ref|NP_181476.1| (NM_129502) hypothetical protein [Arabidopsis thaliana]
pir||T00554 hypothetical protein F12L6.10 - Arabidopsis thaliana
gb|AAC27835.1| (AC004218) hypothetical protein [Arabidopsis thaliana]
Length = 773
Score = 116 bits (290), Expect = 1e-25
Identities = 17/72 (23%), Positives = 39/72 (53%), Gaps = 5/72 (6%)
Query: 58 LPVYLLITVVIGYVLLFGINMMSTSPLDSIHTITDNYAKNQQR-----KNYQEDAIPALR 112
+P YL++T+++ G+N ++T P S++T+ D Y++ + ++ I +
Sbjct: 1 MPTYLMVTLMLALAFYIGLNFIATPPPTSLNTLFDEYSREPGEFAAGMEEGEDRPIDPIS 60
Query: 113 DVPISEVNKMFF 124
D+ I+ +N + F
Sbjct: 61 DIDITRINDLMF 72
>ref|NP_496845.1| (NM_064444) BR-1 protein-like [Caenorhabditis elegans]
emb|CAB07689.2| (Z93393) contains similarity to Pfam domain: PF01926 (GTPase of
unknown function), E-value=0.00012,~cDNA EST
EMBL:AU111138 comes from this gene~cDNA EST
EMBL:AU114976 comes from this gene [Caenorhabditis
elegans]
Length = 890
Score = 109 bits (271), Expect = 2e-23
Identities = 26/56 (46%), Positives = 36/56 (63%)
Query: 6 PSPLPERAIYGFVLFLSSQFGFILYLVWAFVPESWLNSLGLTYWPQKYWAVALPVY 61
P P P R IYGF L++ S F++YL+WA P L LG+TY P K WA+A+ ++
Sbjct: 26 PGPHPARGIYGFALYIVSWTLFVIYLIWAITPVPILYRLGITYIPSKLWALAIGIF 81
>pir||T27023 hypothetical protein Y48E1B.2a - Caenorhabditis elegans
Length = 1768
Score = 107 bits (266), Expect = 1e-22
Identities = 26/56 (46%), Positives = 36/56 (63%)
Query: 6 PSPLPERAIYGFVLFLSSQFGFILYLVWAFVPESWLNSLGLTYWPQKYWAVALPVY 61
P P P R IYGF L++ S F++YL+WA P L LG+TY P K WA+A+ ++
Sbjct: 26 PGPHPARGIYGFALYIVSWTLFVIYLIWAITPVPILYRLGITYIPSKLWALAIGIF 81
>ref|NP_010725.1| (NC_001136) Protein required for cell viability; Ydr437wp
[Saccharomyces cerevisiae]
pir||S69717 hypothetical protein YDR437w - yeast (Saccharomyces cerevisiae)
gb|AAB64854.1| (U33007) Ydr437wp; CAI: 0.10 [Saccharomyces cerevisiae]
Length = 140
Score = 40.8 bits (95), Expect = 0.010
Identities = 25/91 (27%), Positives = 46/91 (50%), Gaps = 10/91 (10%)
Query: 11 ERAIYGFVLFLSSQFGFILYLVWAFVPES--------WLNSLGLTYWPQKYWAVALPVYL 62
+ Y F ++ +L ++W+ +P S ++N+L L +PQ+ W + L +
Sbjct: 3 TKEYYWFSQYMIITSTLVLTIIWSILPSSLGEAAPKQFINTL-LDIFPQRRWIITLESIM 61
Query: 63 LITVVIGYVLLFGINM-MSTSPLDSIHTITD 92
L+ ++ Y+ L N T PLDS+ T+TD
Sbjct: 62 LMGMLCTYIGLLMYNEDTLTPPLDSLSTVTD 92
>gb|AAF56563.1| (AE003754) CG14550 gene product [Drosophila melanogaster]
Length = 138
Score = 38.1 bits (88), Expect = 0.072
Identities = 22/70 (31%), Positives = 37/70 (52%), Gaps = 6/70 (8%)
Query: 25 FGFILYLVWAFVPESWLNSLGLT-YWPQKYWAVALPVYLLI-TVVIGYVLLFGINMMSTS 82
F++Y+ WA +P GL Y P KY+AV +P +L+ +++ IN+ T
Sbjct: 5 VLFLVYVTWALLPVE----FGLHSYLPDKYFAVFVPFLVLVFAWFFAFLIYPAINLSMTV 60
Query: 83 PLDSIHTITD 92
+DSI ++ D
Sbjct: 61 DVDSIASVVD 70
CPU time: 43.19 user secs. 1.75 sys. secs 44.94 total secs.
Database: nr
Posted date: Apr 21, 2002 2:19 PM
Number of letters in database: 277,845,442
Number of sequences in database: 887,402
Lambda K H
0.318 0.169 0.530
Gapped
Lambda K H
0.270 0.0592 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 83894406
Number of Sequences: 887402
Number of extensions: 3652106
Number of successful extensions: 11191
Number of sequences better than 10.0: 38
Number of HSP's better than 10.0 without gapping: 17
Number of HSP's successfully gapped in prelim test: 21
Number of HSP's that attempted gapping in prelim test: 11164
Number of HSP's gapped (non-prelim): 40
length of query: 132
length of database: 277,845,442
effective HSP length: 50
effective length of query: 82
effective length of database: 233,475,342
effective search space: 19144978044
effective search space used: 19144978044
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.4 bits)
S2: 69 (31.0 bits)
