CLUSTAL X (1.8) multiple sequence alignment NP_064419 ---------------------MNILFSPRMRKVSVLLFLAWVCFLFYAGIALFTSGFLLT T02245 -----------------------------MQKASVLLFLAWVCFLFYAGIALFTSGFLLT AAF57689.1 ------------------------------MNLTYLFVLIWLAFLISSGVMLFSRGFLLA T40030 -----------MEEKRVKCKKKLTSTIGTWKYIQACIFFAIILISNFYGLKSFTDGFLLR NP_013069.1 MDEKTIKKSILSSSNDEKIIYKSRIKKFQKNHKFYIILLVFIAILQFISIAFFTRGFLLS NP_197227.1 ---------------------------METYLKNKKLTALGFLLIHAIAILIFTRGFLLT AAB93646.1 --------------------------------MGSIIRILLVSINILLALFIFQNGFLLK : . : .: * **** NP_064419 RLELTNQSSCQELPGPGPLPWGSHGKPG----------ACWMPSRFSRVVLVLIDALRFD T02245 RLELTNHSSCQEPPGPGSLPWGSQGKPG----------ACWMASRFSRVVLVLIDALRFD AAF57689.1 RVSKTETSTCRRLSTNPNAEYVLTDEVVNEIFKDVNASSNLCLPQKSKVIVLVVDALKYE T40030 RAVLNQTSLCENPPADVREWKNSSG--------------CWAPKIFERAVIVIIDALRYD NP_013069.1 RHVLDNISSQNE-TS-------------------------KLPPRFNKAVILVIDALRFD NP_197227.1 RTELPFHSTCSDVSLSP-----------------------------------CLASPRSN AAB93646.1 RQEILSKSSCSDAHAQPGQ-------------------TCWMKQQYQRVILILVDALRYD * * : : : : NP_064419 FAQPQRSHVPGEPPVSVPFLGKLGSLQRILESQPHHGRLYRSQVDPPTTTMQRLKALTTG T02245 FAQPQHSH-------------------RILEIQPHHARLYRSQVDPPTTTMQRLKALTTG AAF57689.1 FGLYRANATDP-----LPYENKLVVLQELLQQNPDHARLMRFRADPPTTTLQRLKGLTTG T40030 FLIPYNDSN--------YYHNAFTTPYETSVLHPENSYLTQFIADAPTTTSQRLKGLTTG NP_013069.1 FAIPVNESHSNYN--LNYHNNILSLYDSFASDKDASSLLLKFIADPPTTTLQRLKGLTTG NP_197227.1 HDSSSEPK---------PWMDKLTILQTLAFANDSSAKIFKAFADPPTTSLQRLKGLTTG AAB93646.1 FLIPIDENTKKSK---EEWYYRGQMKNIEKLVKSGNVSIGTLLADPPTTTLQRLKALTTG . : : .*.***: ****.**** NP_064419 SLPTFIDAGSNFASHAIV-EDNVIQQLNSAGRRVVFMGDDTWRDLFPGAFSQAFFFS--S T02245 SLPTFIDAGSNFASHAIV-EDNLIKQLTSAGRRVVFMGDDTWKDLFPGAFSKAFFFP--S AAF57689.1 SLPTFIDIGSNFASPEIN-EDNIIDQIVKNDLPVVFLGDSTWTDLYPHRFKRSYSYP--S T40030 SLPTFIDLGSNFAGTNID-EDNLLLQWKSLDKQIVLLGDDTWDVLFHDYLNETLSQPAFS NP_013069.1 SLPTFIDAGSNFDGTVIE-EDNFLKQLHLANKTVKFAGDDTWMALFHPFLSND-SFPLES NP_197227.1 GLPTFIDIGNSFGAPAIV-EDNFINQLVLNGKRLVMMGDDTWTQLFPNQFQKSYPFP--S AAB93646.1 TLPTFIDAGDNFSPDAVISEDSFVYQAAQLGKNVTLLGDDTWLSLFPNQFSKTAAYD--S ****** *..* : **..: * . : : **.** *: :.. * NP_064419 FNVRDLHTVDNGILEHLYPTLD------------------GGSWDVLIAHFLGVDHCGHK T02245 FNVRDLDTVDNGILEHLYPTMD------------------SGEWDVLIAHFLGVDHCGHK AAF57689.1 FDIFDLDSVDNEILKHLPKELE------------------SKDWQVLVAHFLGVDHCGHK T40030 FNVPDLHGVDNKVNQYVFDYIK------------------DANFDVLIAHYLGVDHVGHR NP_013069.1 LNVWDLDTVDNGVMDYFHDHLQQ-----------------DKEWDVMIGHMLGIDHVGHK NP_197227.1 FNVKDLDTVDNGCIEHLFPTLF------------------KDDWDVLIAHFLGVDHAGHI AAB93646.1 FDINDLNTVDDKIARKIFFGKYYNKMVFCFEGPILQDEMLNSNSSIIIAHFLGVDHCGHK ::: **. **: . . .:::.* **:** ** NP_064419 HGPHHPEMAKKLSQMDQVIQGLIERLE---------NDTLLVVAGDHGMTMNGDHGGDSE T02245 HGPHHPEMAKKLSQMDQVIQGLVERLE---------NDTLLVVAGDHGMTTNGDHGGDSE AAF57689.1 HGPMHEEMARKLGEMNEVIRSVVAAMD---------NDTTLLVMGDHGMTASGDHGGDTD T40030 LGPDHPTMRDKLNQMDRCVKEMMDLLD---------DSTLLIVMGDHGMDNKGNHGGDSF NP_013069.1 YGPDHFTMREKQIQVDQFIDWILKSID---------DDTLLVILGDHGMDHTGNHGGDSI NP_197227.1 FGVDSSPMINKLEQYNSVLEKVINILESQAGPGGLHENTMLIVMGDHGQTLNGDHGGGTA AAB93646.1 FGPSHPVMADTLRKMDRIIGQTIETMK---------------SD-DHGMTSTGDHGGESE * * . : : : : :. *** .*:*** : NP_064419 LEVSAALFLYSPTALFPSVPP----------EEPEVIPQVSLVPTLALLLGLPIPFG--- T02245 LEVSAALFLYSPTAVFPSTPP----------EEPEVIPQVSLVPTLALLLGLPIPFG--- AAF57689.1 DETNALLFAYSKQHRFYGNDSG---------SDSEMLQQIDLVPTLATILGVPIPYS--- T40030 DEINSVLWMYSKKPTFGYLKQP---------GKVLSANQVDLVPTLSLLLGNPIPYG--- NP_013069.1 DELESTLFLYSKKPDMWRLKETSNYNIDNLGHDYRSVRQIDLVSSLALLMGQPIPFN--- NP_197227.1 EEVETTMFAMSTKKHTTLVPPEFDTSSCK-QNKDGKQMCISYIEQQHCQLCLGYPFLSEG AAB93646.1 NEIRAGILVHSKKHQIILPER------------P--IHQIDIVPTISLLMGLPIPFS--- * : : * :. : : *: NP_064419 -NTGEVMAELFSGGSDSSHPHSSAL--------------AQVSALHINAQQVSRFLHTYS T02245 -NIGEVMAELFSGGEDS-QPHSSAL--------------AQASALHLNAQQVSRFLHTYS AAF57689.1 -NLGLVNFNIVPDLRVP--HLNKFQ--------------TLLLHSWQNAQQIYRYFFQYA T40030 -NLGTLIPEPFYYYGDEY----------------------LSKAQKINIGQLNRFFSEYD NP_013069.1 -NLGWPIDEIARNDREWS-QFVNSA--------------ISQLQLYKDTMQIHHGNDEIL NP_197227.1 AFIGHVNPELYALGSSSWNLDKSDLGNFGTQSAANEWMKHYVDVLCVNAWQVKRYIDVYS AAB93646.1 -NLGTVITQLFTRDLWEIARQMMGFVWQDSVG-------IFAETYAAQKNFGELHSHTIR * : : NP_064419 AAT-QDLQVKELHRLQTLFSKASARYQHFLRDP----------QEAEAALSTLTAEFQQF T02245 AAT-QDLQAKELHQLQNLFSKASADYQWLLQSP----------KGAEATLPTVIAELQQF AAF57689.1 LENKRTFNVEQMDHLETEFILLTHRVQTVYN---------------EVAFKSFVRDLNTN T40030 LDASDFLSSSVHKNNNSYLDQYFLDFDYARDAFSYFK-----AIWAEFSLFPMIIGFLLL NP_013069.1 EPLAKNISNTPPTSDPEKFVKLGHKYQKVFLQT---------CEELWAKFDYYSIATGIT NP_197227.1 NSSVVGFSSDDMSRISDLYSAAEQNWSNSVKHILMDRNGDDGSTDISALLKEQIAEYLNF AAB93646.1 DSNTMEEQLDTMSRIQTLLRVSWTQFDDAYINAG-------IFSLVEAIMFLITNEVMSL . . : NP_064419 LRGARALCIESWARFSLVRMAGGAALLAAACLLCLLASQLAVAPGFLFRPLLLIPVAWGL T02245 LRGARAMCIESWARFSLVRMAG-------------------------------------- AAF57689.1 LRDILGTCREIWVRFDPTQMSQGLLFTFLPLFFIFLVVNNSRPADFPHIFKAKEVFYVYL T40030 IIGGFNLALLMQDKSVIFRMSANMAPSVMKCLPVCLILILAN------------------ NP_013069.1 LLATSLVLLISITKLIPSIVVNQMVPEFVPGIIIMVLVTNLCFHGIFYVYQQP------- NP_197227.1 FSSVVELARSKWTEFNLNLMITGFGILVISLILQFLAVFHGD------------------ AAB93646.1 EWIIYRTGCGLLQAALLTDKTDSDG-SARTLLLMTLAVSCLSS----------------- NP_064419 T------WTILYAGVSVTTGSKIDLVVLGAVAAAGSLLPFLWKAWVSRGSKRPLAPLLPV T02245 ------------------------------------------------------------ AAF57689.1 INLAAGVFGYRYFKTFSFKTEEQGVIFFTAISSAVILAFHTLRHWTSIATNWSAVKRFG- T40030 -------------------------------------------------------NELHS NP_013069.1 ------SFVDQFWG----------TLLATAIGIIIGCYITIFDRYNFIWIAMRLGETLAD NP_197227.1 ------------------------------------------KSYAVG--------SWLS AAB93646.1 -----------------------------------------IISMCHKALQIRISIKSML NP_064419 PRP--VLILLLIRLATFFSDSFFVVEARATPFLLGSLVFFLVAQLHWEGQLLPPKPLTMS T02245 ------------------------------------------------------------ AAF57689.1 HMP--TRLLLFGSMAVFFSNSFVIQEAKILSYLLAAAILLLSHELLRLSARLDFR----- T40030 PFP--AEFYVLLPSFYILLNSFN---QKLMEYFKG------------------------- NP_013069.1 YWSRIAVMFMIIHALLFTSNSFTIWEDRIVAFLLS------------------------- NP_197227.1 TGAAFTLFIVTIRACSFLSNSYILEEGK-------------------------------- AAB93646.1 SAKVIGPILVIIHSISLFSNSYVVYEAQVVR----------------------------- NP_064419 RLGSSAPTAPPRHSGAHALWLGIGLLLFTRLAGLFHRCPEETPACRSSPWLSPLASMVGG T02245 ------------------------------------------------------------ AAF57689.1 --TKFKASQFLRSTALRLILASVLAICLIRFAYTLFRCREEQGNCSDFVNTGGAGFSLKK T40030 ---------------------FVKLDYFSIFITFLHVCS--------------------- NP_013069.1 ---------------------TFGMLTLYEFVFLPKR-Q--------------------- NP_197227.1 ------------------------------------------------------------ AAB93646.1 ---------------------YFL------------------------------------ NP_064419 RAKNLWYGACVGALVALLVVVRLWLRRYGNLKSPEPPVLFVRWGMPLMVLGTAAYWALAS T02245 -AKNLWYGACVAALVALLAAVRLWLRRYGNLKSPEPPMLFVRWGLPLMALGTAAYWALAS AAF57689.1 PGTGKTYILAVVVLVVYTTLTRLYLRSCGNLTGNLPNVLLARYGPTVASICAGGHILLAN T40030 -FGSNSFTVWEDRLCHFLIITIGLVMFCKCFSEMSPLFACSTYSALAFILLQVISSYVTN NP_013069.1 -STTALLTATISEKEGTTSGVNPSTANSNYLPLTRFARLLGGYHSAVLIIFTRLASMITI NP_197227.1 --VANFLLATTGLIKLRYSVMRKTMRKEAFMFLAMVFVLRVSIDIGLTKQAATSQFMSSS AAB93646.1 --QSLVTLVFLEKLRSTALRPRKPFKLNFLWKFVNQDQNLIIFTLIMVGLRSEPIFHRCR NP_064419 GAEEAPPRLRALVAGASAVLPRAVMGLAALGLVLLLWRPVTVLVKAGAATSRTRTILTPF T02245 GADEAPPRLRVLVSGASMVLPRAVAGLAASGLALLLWKPVTVLVKAGAGAPRTRTVLTPF AAF57689.1 ------SSIKHIQRTHIDAMALVIYGLLLVQIIVLSWAPLMTFVLP------------PR T40030 CREEQGAFCVSTYISTPDNSLRTLIVLALMALSSIILPLILQLHLR-------RVLGLSL NP_013069.1 CREEQGEYCIPTFNNQ-NNSSWWVLGLCFLMIFILPACITGYYNLTS---SYQAAAPIWI NP_197227.1 ------PSWMLGIAPDHPALTYAIEIAPILSVVILICVLYVAIAKAP---------NEGV AAB93646.1 EEEVGCDTYYPSRQAG-SLTRDAQVVRLLFALGSLAVANLSVFKYYG------------L : : NP_064419 SGPPTSQADLDYVVPQIYRHMQEEFQGRLERTKAQGPITVAAYQLGSVYSAAMVTALLLL T02245 SGPPTSQADLDYVVPQIYRHMQEEFRGRLERTKSQGPLTVAAYQLGSVYSAAMVTALTLL AAF57689.1 SSHTVTINGNESIVPEIFRKMKRMYEGDDDERRS---HIPVVYGLATVYSSIVIAFGVFL T40030 KLYHLSILYFFELISSIFWIAHHVFANDALLEKQ---YHHVLYSLANTYVICILGVLIWQ NP_013069.1 NVFLKGILGLNFVYWSLTSLENNSAVIAIPFLRDVTIFKFTLARIIAGFSLIASNVGWLM NP_197227.1 WKYVTVGSMLLQVTGGRNRIPQTVYVIGLVQLCLLASARMFCTEKDKNWAIRTVALVSAC AAB93646.1 RDTKSQIESNSKRSSETIRILSATSWLHIAIIVLHSVFASLTHDVSRANLSAHSLSVISL NP_064419 AFPLMLLHVERVSLV--------------FLLLFLQSFLLLHLLAAGTPVATPG------ T02245 AFPLLLLHAERISLV--------------FLLLFLQSFLLLHLLAAGIPVTTPGKYLSSD AAF57689.1 ALVMIVLLEPRASIG--------------LVVCVAVGAILLSVHSILRYRTATS------ T40030 FFLLSRSKFAKINVI--------------ERSYFVFALLYSFLSFLQRPLGHLS------ NP_013069.1 GPLCIKLNIHNTDVKSHEATILGYTNIYGSEFFLLVINVLISILLFNKPLAQLS------ NP_197227.1 SSPIILLSGKQGSML--------------ALVYLVAGYCIMRLEGVERRTKSDG------ AAB93646.1 ICAVLAWREGNSAIC--------------AHFLLMPVYILFGDGLIPAIIIFIAVS---- . : . . NP_064419 ------------------------------------------------------------ T02245 SLKDNSDVSSAPLVFKEVLLLMFLSLTEGPMPHTTRKVFLVSSLLPAIAKQIDPSCWFPG AAF57689.1 ------------------------------------------------------------ T40030 --------------------------------------------------------LFSC NP_013069.1 --------------------------------------------------------YFLM NP_197227.1 ------------------------------------------------------------ AAB93646.1 ------------------------------------------------------------ NP_064419 --------------PFTVLWQAVSAWVLLATQTFYSTGHQPVFSAIHWHAAFVGFPDGHG T02245 FMERRDKESSKTPCPFTVPWQAVSAWALMATQTFYSTGHQPVFPAIHWHAAFVGFPEGHG AAF57689.1 -----------FESCVQPTFTALVGWFLLAHFCFFATSHQTTLSQIEWRAAFVGRTTGIG T40030 FLQILLLIQLKQWQPSVGHNFFSVTLGLLGLSHFFTTGNQAAISSLDWNFAFIHSKS--A NP_013069.1 CNQLLSILEIIDLLKLKENIIGPIALGLLSYQHFFTTGHQATIPSVQWDIGFMLSEK--- NP_197227.1 -----------QSKFSKLNPLCVVQWSLLSICMFFASGHWCAFDGLRYGAAFVGFDE--- AAB93646.1 ----------VLIAEFVSREFIASTIALLIPLGFYHLGHSPVISSIPWNAAFVGIPG--G *: *: .: .: : : .*: NP_064419 SSTWLPALLVGANTFASHLLFAVG-CPLL------LLWPFLCERQGPKRRQPLPGSESEA T02245 SCTWLPALLVGANTFASHLLFAVG-CPLL------LLWPFLCESQGLRKRQQPPGNEADA AAF57689.1 QSNLVSGALVILNTFCGPIFFFCM-YSLLSTETFSLFALFPNLIRSCRSGGKVDASTSMS T40030 ENQAISAIFMFLHTVGAPILTCIS-IPLF-------------------------S--FEP NP_013069.1 VTFPFTQIAIILNTFGPHILVSLS-VALLT------------------------LWSQPP NP_197227.1 FVLIRQAILLTIETFGFSIILSVFGLPLLIP-----------------------FHSQTP AAB93646.1 TALRVLPALFVLFHLNFSAISSIFVISSE-------------------------SESSQK . . : . NP_064419 RVRPEEEEELQEPLMEVRLRDAPNHFNAALLQLGLKYLFILGAQILACALAASILRRHLM T02245 RVRPEEEE---EPLMEMRLRDAPQHFYAALLQLGLKYLFILG-----S---------YLR AAF57689.1 DLANEAVG-FDMTRGELSLYEYEDVFLGTGFKLATQFFMLQGLKIFCAMLACTIHCRHLM T40030 LSKKN--------RFLINLFRFSFSFILYNLLISTSTVFFAG-----------FFRRHLM NP_013069.1 DVLKP-------QTLLGRIVSNCGILLTYNTILCLSSFIWVT-----------HFRRHLM NP_197227.1 QAHGE---------KRHQLFQMYMLFGVISATTVTATILCVT-----------IQRRHLM AAB93646.1 MSAPN------------TAWTLTETLVLMTIRATLTCLVSS------------IHRRHLM : .. :* NP_064419 VWKVFAPKFIFEAVGFIVSSVGLLLGIALVMR--VDVAVSSWFKKLVLAQQR T02245 LWASL----------------------------------------------- AAF57689.1 VWKIFAPRFIYEALATFVSLPALIVGYLLVLR--IHRGVDTLIKRINKAKVH T40030 VWKVFAPRFMLSG--------ILLVTHQLFVL--IQCFGSSVVKFPEDAE-- NP_013069.1 VWKIFCPRFIFAS-------LSLIVTQLVVTFGTIAFASGRLIKHINDIFWK NP_197227.1 VWGLFAPKFVFDVVD-------LILTDLLICLASAYYL-------------- AAB93646.1 VWKIFAPKFIFECILT----IVFIFSANFFLIYRQFFGEKFKNSEAKINKLH :* :