analysis of sequence from NP_036459.1.fa ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ >NP_036459.1 phosphatidylinositol glycan, class N; [Homo sapiens]. MLLFFTLGLL IHFVFFASIF DIYFTSPLVH GMTPQFTPLP PPARRLVLFV ADGLRADALY ELDENGNSRA PFIRNIIMHE GSWGISHTRV PTESRPGHVA LIAGFYEDVS AVAKGWKENP VEFDSLFNES KYTWSWGSPD ILPMFAKGAS GDHVYTYSYD AKREDFGAQD ATKLDTWVFD NVKDFFHHAR NNQSLFSKIN EEKIVFFLHL LGIDTNGHAH RPSSRDYKHN IKKVDDGVKE IVSMFNHFYG NDGKTTFIFT SDHGMTDWGS HGAGHPSETL TPLVTWGAGI KYPQRVSAQQ FDDAFLKEWR LENWKRLDVN QADIAPLMTS LIGVPFPLNS VGILPVDYLN NTDLFKAESM FTNAVQILEQ FKVKMTQKKE VTLPFLFTPF KLLSDSKQFN ILRKARSYIK HRKFDEVVSL CKELIHLALK GLSYYHTYDR FFLGVNVVIG FVGWISYASL LIIKSHSNLI KGVSKEVKKP SHLLPCSFVA IGILVAFFLL IQACPWTYYV YGLLPLPIWY AVLREFQVIQ DLVVSVLTYP LSHFVGYLLA FTLGIEVLVL SFFYRYMLTA GLTAFAAWPF LTRLWTRAKM TSLSWTFFSL LLAVFPLMPV VGRKPDISLV MGAGLLVLLL SLCVVTSLMK RKDSFIKEEL LVHLLQVLST VLSMYVVYST QSSLLRKQGL PLMNQIISWA TLASSLVVPL LSSPVLFQRL FSILLSLMST YLLLSTGYEA LFPLVLSCLM FVWINIEQET LQQSGVCCKQ KLTSIQFSYN TDITQFRQLY LDDIRRAFFL VFFLVTAFFG TGNIASINSF DLASVYCFLT VFSPFMMGAL MMWKILIPFV LVMCAFEAVQ LTTQLSSKSL FLIVLVISDI MALHFFFLVK DYGSWLDIGT SISHYVIVMS MTIFLVFLNG LAQLLTTKKL RLCGKPKSHF M ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ sec.str. with predator > NP_036459.1 . . . . . 1 MLLFFTLGLLIHFVFFASIFDIYFTSPLVHGMTPQFTPLPPPARRLVLFV 50 ___HHHHHHHHHHHHHHHHEEEEE___________________HHHHHHH . . . . . 51 ADGLRADALYELDENGNSRAPFIRNIIMHEGSWGISHTRVPTESRPGHVA 100 H___HHHHHHHH________HHHHHHH____________________EEE . . . . . 101 LIAGFYEDVSAVAKGWKENPVEFDSLFNESKYTWSWGSPDILPMFAKGAS 150 E_______HHHHHHHH______________EEEEE______HHHHHH___ . . . . . 151 GDHVYTYSYDAKREDFGAQDATKLDTWVFDNVKDFFHHARNNQSLFSKIN 200 ___EEEEE_________________EEEE______________HHHHH_H . . . . . 201 EEKIVFFLHLLGIDTNGHAHRPSSRDYKHNIKKVDDGVKEIVSMFNHFYG 250 HHHHHHHHHHH___________________EEE_____EEEEE_______ . . . . . 251 NDGKTTFIFTSDHGMTDWGSHGAGHPSETLTPLVTWGAGIKYPQRVSAQQ 300 ____EEEEE_______________________EEEE______HHHHHHHH . . . . . 301 FDDAFLKEWRLENWKRLDVNQADIAPLMTSLIGVPFPLNSVGILPVDYLN 350 HHHHHHHHHHHHHHHHHHHH____HHHHHHH________EEEE_______ . . . . . 351 NTDLFKAESMFTNAVQILEQFKVKMTQKKEVTLPFLFTPFKLLSDSKQFN 400 __HHHHHHHHH_HHHHHHHHHHHHHHHH_EEEE_______EEE_____HH . . . . . 401 ILRKARSYIKHRKFDEVVSLCKELIHLALKGLSYYHTYDRFFLGVNVVIG 450 HHHHHHHHHHH____HHHHHHHHHHHHHHH___EEEE_______EEEEEE . . . . . 451 FVGWISYASLLIIKSHSNLIKGVSKEVKKPSHLLPCSFVAIGILVAFFLL 500 E____HHHHHEEEE___EEEEE_____________EEEEHHHHHHHHHHH . . . . . 501 IQACPWTYYVYGLLPLPIWYAVLREFQVIQDLVVSVLTYPLSHFVGYLLA 550 HH_____EEEEE_____HHHHHHHHHHHHHHHHHHH______HHHHHHHH . . . . . 551 FTLGIEVLVLSFFYRYMLTAGLTAFAAWPFLTRLWTRAKMTSLSWTFFSL 600 HHH__EEEEHHHHHHHHHHHHHHHHH____HHHHHHHHHHHHHHHHHHHH . . . . . 601 LLAVFPLMPVVGRKPDISLVMGAGLLVLLLSLCVVTSLMKRKDSFIKEEL 650 HHH______________EEEEHHHHHHHHHHHHHHHHHHHHH__HHHHHH . . . . . 651 LVHLLQVLSTVLSMYVVYSTQSSLLRKQGLPLMNQIISWATLASSLVVPL 700 HHHHHHHHHHHHHEEEEEE___HHHHH_______EEEHHHHHHHHHEEE_ . . . . . 701 LSSPVLFQRLFSILLSLMSTYLLLSTGYEALFPLVLSCLMFVWINIEQET 750 ___HHHHHHHHHHHHHHHHHHH_________HHHHHHHHHHHHHHHHHHH . . . . . 751 LQQSGVCCKQKLTSIQFSYNTDITQFRQLYLDDIRRAFFLVFFLVTAFFG 800 HHH________EEE_EEE____HHHHHHHHHHHHHHHHHHHHHHHHH___ . . . . . 801 TGNIASINSFDLASVYCFLTVFSPFMMGALMMWKILIPFVLVMCAFEAVQ 850 ____EEEE___HHHHHHHHH___HHHHHHHHHHHH_HHHHHHHHHHHHHH . . . . . 851 LTTQLSSKSLFLIVLVISDIMALHFFFLVKDYGSWLDIGTSISHYVIVMS 900 HHH______EEEEEHHHHHHHHHHHEEEEE____EEE_____EEEEEEE_ . . . 901 MTIFLVFLNGLAQLLTTKKLRLCGKPKSHFM 931 ___EEE___HHHHHHHHHHHEEEE_______ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ method : 1 alpha-contents : 17.6 % beta-contents : 62.3 % coil-contents : 20.1 % class : mixed method : 2 alpha-contents : 0.0 % beta-contents : 77.7 % coil-contents : 22.3 % class : beta ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ GPI: learning from metazoa -10.62 -1.40 -0.21 -0.32 -4.00 0.00 -32.00 -0.33 -0.87 -2.08 -2.25 0.00 -12.00 -4.00 0.00 0.00 -70.08 -6.00 -2.59 -3.36 -1.27 0.00 0.00 0.00 -9.21 -3.34 -3.45 -4.09 0.00 -12.00 -4.00 -12.00 0.00 -61.32 ID: NP_036459.1 AC: xxx Len: 931 1:I 900 Sc: -61.32 Pv: 3.929886e-01 NO_GPI_SITE GPI: learning from protozoa -24.43 -6.74 -2.08 -3.34 -4.00 0.00 -28.00 -0.52 -0.09 -1.82 -7.60 0.00 -12.00 -4.00 0.00 0.00 -94.61 -19.58 -1.54 -0.26 0.00 -4.00 0.00 -32.00 -0.76 -0.24 -1.96 -8.39 0.00 -12.00 -4.00 0.00 0.00 -84.74 ID: NP_036459.1 AC: xxx Len: 931 1:I 892 Sc: -84.74 Pv: 5.965573e-01 NO_GPI_SITE ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ # SignalP euk predictions # name Cmax pos ? Ymax pos ? Smax pos ? Smean ? NP_036459.1 0.945 504 Y 0.577 638 Y 0.996 7 Y 0.286 N # SignalP gram- predictions # name Cmax pos ? Ymax pos ? Smax pos ? Smean ? NP_036459.1 0.424 18 N 0.515 18 Y 0.995 9 Y 0.861 Y # SignalP gram+ predictions # name Cmax pos ? Ymax pos ? Smax pos ? Smean ? NP_036459.1 0.895 577 Y 0.534 504 Y 0.995 793 Y 0.247 N ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ low complexity regions: SEG 12 2.2 2.5 >NP_036459.1 phosphatidylinositol glycan, class N; [Homo sapiens]. 1-381 MLLFFTLGLLIHFVFFASIFDIYFTSPLVH GMTPQFTPLPPPARRLVLFVADGLRADALY ELDENGNSRAPFIRNIIMHEGSWGISHTRV PTESRPGHVALIAGFYEDVSAVAKGWKENP VEFDSLFNESKYTWSWGSPDILPMFAKGAS GDHVYTYSYDAKREDFGAQDATKLDTWVFD NVKDFFHHARNNQSLFSKINEEKIVFFLHL LGIDTNGHAHRPSSRDYKHNIKKVDDGVKE IVSMFNHFYGNDGKTTFIFTSDHGMTDWGS HGAGHPSETLTPLVTWGAGIKYPQRVSAQQ FDDAFLKEWRLENWKRLDVNQADIAPLMTS LIGVPFPLNSVGILPVDYLNNTDLFKAESM FTNAVQILEQFKVKMTQKKEV tlpflftpfkll 382-393 394-590 SDSKQFNILRKARSYIKHRKFDEVVSLCKE LIHLALKGLSYYHTYDRFFLGVNVVIGFVG WISYASLLIIKSHSNLIKGVSKEVKKPSHL LPCSFVAIGILVAFFLLIQACPWTYYVYGL LPLPIWYAVLREFQVIQDLVVSVLTYPLSH FVGYLLAFTLGIEVLVLSFFYRYMLTAGLT AFAAWPFLTRLWTRAKM tslswtffslll 591-602 603-617 AVFPLMPVVGRKPDI slvmgagllvlllslcvvtsl 618-638 639-693 MKRKDSFIKEELLVHLLQVLSTVLSMYVVY STQSSLLRKQGLPLMNQIISWATLA sslvvpllsspvl 694-706 707-711 FQRLF sillslmstyllls 712-725 726-784 TGYEALFPLVLSCLMFVWINIEQETLQQSG VCCKQKLTSIQFSYNTDITQFRQLYLDDI rrafflvfflvtaffgtg 785-802 803-931 NIASINSFDLASVYCFLTVFSPFMMGALMM WKILIPFVLVMCAFEAVQLTTQLSSKSLFL IVLVISDIMALHFFFLVKDYGSWLDIGTSI SHYVIVMSMTIFLVFLNGLAQLLTTKKLRL CGKPKSHFM low complexity regions: SEG 25 3.0 3.3 >NP_036459.1 phosphatidylinositol glycan, class N; [Homo sapiens]. 1-603 MLLFFTLGLLIHFVFFASIFDIYFTSPLVH GMTPQFTPLPPPARRLVLFVADGLRADALY ELDENGNSRAPFIRNIIMHEGSWGISHTRV PTESRPGHVALIAGFYEDVSAVAKGWKENP VEFDSLFNESKYTWSWGSPDILPMFAKGAS GDHVYTYSYDAKREDFGAQDATKLDTWVFD NVKDFFHHARNNQSLFSKINEEKIVFFLHL LGIDTNGHAHRPSSRDYKHNIKKVDDGVKE IVSMFNHFYGNDGKTTFIFTSDHGMTDWGS HGAGHPSETLTPLVTWGAGIKYPQRVSAQQ FDDAFLKEWRLENWKRLDVNQADIAPLMTS LIGVPFPLNSVGILPVDYLNNTDLFKAESM FTNAVQILEQFKVKMTQKKEVTLPFLFTPF KLLSDSKQFNILRKARSYIKHRKFDEVVSL CKELIHLALKGLSYYHTYDRFFLGVNVVIG FVGWISYASLLIIKSHSNLIKGVSKEVKKP SHLLPCSFVAIGILVAFFLLIQACPWTYYV YGLLPLPIWYAVLREFQVIQDLVVSVLTYP LSHFVGYLLAFTLGIEVLVLSFFYRYMLTA GLTAFAAWPFLTRLWTRAKMTSLSWTFFSL LLA vfplmpvvgrkpdislvmgagllvlllslc 604-639 vvtslm 640-649 KRKDSFIKEE llvhllqvlstvlsmyvvystqssll 650-675 676-687 RKQGLPLMNQII swatlasslvvpllsspvlfqrlfsillsl 688-739 mstylllstgyealfplvlscl 740-931 MFVWINIEQETLQQSGVCCKQKLTSIQFSY NTDITQFRQLYLDDIRRAFFLVFFLVTAFF GTGNIASINSFDLASVYCFLTVFSPFMMGA LMMWKILIPFVLVMCAFEAVQLTTQLSSKS LFLIVLVISDIMALHFFFLVKDYGSWLDIG TSISHYVIVMSMTIFLVFLNGLAQLLTTKK LRLCGKPKSHFM low complexity regions: SEG 45 3.4 3.75 >NP_036459.1 phosphatidylinositol glycan, class N; [Homo sapiens]. 1-504 MLLFFTLGLLIHFVFFASIFDIYFTSPLVH GMTPQFTPLPPPARRLVLFVADGLRADALY ELDENGNSRAPFIRNIIMHEGSWGISHTRV PTESRPGHVALIAGFYEDVSAVAKGWKENP VEFDSLFNESKYTWSWGSPDILPMFAKGAS GDHVYTYSYDAKREDFGAQDATKLDTWVFD NVKDFFHHARNNQSLFSKINEEKIVFFLHL LGIDTNGHAHRPSSRDYKHNIKKVDDGVKE IVSMFNHFYGNDGKTTFIFTSDHGMTDWGS HGAGHPSETLTPLVTWGAGIKYPQRVSAQQ FDDAFLKEWRLENWKRLDVNQADIAPLMTS LIGVPFPLNSVGILPVDYLNNTDLFKAESM FTNAVQILEQFKVKMTQKKEVTLPFLFTPF KLLSDSKQFNILRKARSYIKHRKFDEVVSL CKELIHLALKGLSYYHTYDRFFLGVNVVIG FVGWISYASLLIIKSHSNLIKGVSKEVKKP SHLLPCSFVAIGILVAFFLLIQAC pwtyyvygllplpiwyavlrefqviqdlvv 505-742 svltyplshfvgyllaftlgievlvlsffy rymltagltafaawpfltrlwtrakmtsls wtffslllavfplmpvvgrkpdislvmgag llvlllslcvvtslmkrkdsfikeellvhl lqvlstvlsmyvvystqssllrkqglplmn qiiswatlasslvvpllsspvlfqrlfsil lslmstylllstgyealfplvlsclmfv 743-931 WINIEQETLQQSGVCCKQKLTSIQFSYNTD ITQFRQLYLDDIRRAFFLVFFLVTAFFGTG NIASINSFDLASVYCFLTVFSPFMMGALMM WKILIPFVLVMCAFEAVQLTTQLSSKSLFL IVLVISDIMALHFFFLVKDYGSWLDIGTSI SHYVIVMSMTIFLVFLNGLAQLLTTKKLRL CGKPKSHFM low complexity regions: XNU # Score cutoff = 21, Search from offsets 1 to 4 # both members of each repeat flagged # lambda = 0.347, K = 0.200, H = 0.664 >NP_036459.1 phosphatidylinositol glycan, class N; [Homo sapiens]. MLLFFTLGLLIHFVFFASIFDIYFTSPLVHGMTPQFTPLPPPARRLVLFVADGLRADALY ELDENGNSRAPFIRNIIMHEGSWGISHTRVPTESRPGHVALIAGFYEDVSAVAKGWKENP VEFDSLFNESKYTWSWGSPDILPMFAKGASGDHVYTYSYDAKREDFGAQDATKLDTWVFD NVKDFFHHARNNQSLFSKINEEKIVFFLHLLGIDTNGHAHRPSSRDYKHNIKKVDDGVKE IVSMFNHFYGNDGKTTFIFTSDHGMTDWGSHGAGHPSETLTPLVTWGAGIKYPQRVSAQQ FDDAFLKEWRLENWKRLDVNQADIAPLMTSLIGVPFPLNSVGILPVDYLNNTDLFKAESM FTNAVQILEQFKVKMTQKKEVTLPFLFTPFKLLSDSKQFNILRKARSYIKHRKFDEVVSL CKELIHLALKGLSYYHTYDRFFLGVNVVIGFVGWISYASLLIIKSHSNLIKGVSKEVKKP SHLLPCSFVAIGILVAFFLLIQACPWTYYVYGLLPLPIWYAVLREFQVIQDLVVSVLTYP LSHFVGYLLAFTLGIEVLVLSFFYRYMLTAGLTAFAAWPFLTRLWTRAKMTSLSWTFFSL LLAVFPLMPVVGRKPDISLVMGAGLLVLLLSLCVVTSLMKRKDSFIKEELLVHLLQVLST VLSMYVVYSTQSSLLRKQGLPLMNQIISWatlasslvvpllsspvlfqrlfsillslmST YLLLSTGYEALFPLVLSCLMFVWINIEQETLQQSGVCCKQKLTSIQFSYNTDITQFRQLY LDDIRRafflvfflvTAFFGTGNIASINSFDLASVYCFLTVFSPFMMGALMMWKILIPFV LVMCAFEAVQLTTQLSSKSLFLIVLVISDIMALHFFFLVKDYGSWLDIGTSISHYVIVMS MTIFLVFLNGLAQLLTTKKLRLCGKPKSHFM 1 - 689 MLLFFTLGLL IHFVFFASIF DIYFTSPLVH GMTPQFTPLP PPARRLVLFV ADGLRADALY ELDENGNSRA PFIRNIIMHE GSWGISHTRV PTESRPGHVA LIAGFYEDVS AVAKGWKENP VEFDSLFNES KYTWSWGSPD ILPMFAKGAS GDHVYTYSYD AKREDFGAQD ATKLDTWVFD NVKDFFHHAR NNQSLFSKIN EEKIVFFLHL LGIDTNGHAH RPSSRDYKHN IKKVDDGVKE IVSMFNHFYG NDGKTTFIFT SDHGMTDWGS HGAGHPSETL TPLVTWGAGI KYPQRVSAQQ FDDAFLKEWR LENWKRLDVN QADIAPLMTS LIGVPFPLNS VGILPVDYLN NTDLFKAESM FTNAVQILEQ FKVKMTQKKE VTLPFLFTPF KLLSDSKQFN ILRKARSYIK HRKFDEVVSL CKELIHLALK GLSYYHTYDR FFLGVNVVIG FVGWISYASL LIIKSHSNLI KGVSKEVKKP SHLLPCSFVA IGILVAFFLL IQACPWTYYV YGLLPLPIWY AVLREFQVIQ DLVVSVLTYP LSHFVGYLLA FTLGIEVLVL SFFYRYMLTA GLTAFAAWPF LTRLWTRAKM TSLSWTFFSL LLAVFPLMPV VGRKPDISLV MGAGLLVLLL SLCVVTSLMK RKDSFIKEEL LVHLLQVLST VLSMYVVYST QSSLLRKQGL PLMNQIISW 690 - 718 a tlasslvvpl lsspvlfqrl fsillslm 719 - 786 ST YLLLSTGYEA LFPLVLSCLM FVWINIEQET LQQSGVCCKQ KLTSIQFSYN TDITQFRQ LY LDDIRR 787 - 795 affl vfflv 796 - 931 TAFFG TGNIASINSF DLASVYCFLT VFSPFMMGAL MMWKILIPFV LVMCAFEAVQ LTTQL SSKSL FLIVLVISDI MALHFFFLVK DYGSWLDIGT SISHYVIVMS MTIFLVFLNG LAQLL TTKKL RLCGKPKSHF M low complexity regions: DUST >NP_036459.1 phosphatidylinositol glycan, class N; [Homo sapiens]. MLLFFTLGLLIHFVFFASIFDIYFTSPLVHGMTPQFTPLPPPARRLVLFVADGLRADALY ELDENGNSRAPFIRNIIMHEGSWGISHTRVPTESRPGHVALIAGFYEDVSAVAKGWKENP VEFDSLFNESKYTWSWGSPDILPMFAKGASGDHVYTYSYDAKREDFGAQDATKLDTWVFD NVKDFFHHARNNQSLFSKINEEKIVFFLHLLGIDTNGHAHRPSSRDYKHNIKKVDDGVKE IVSMFNHFYGNDGKTTFIFTSDHGMTDWGSHGAGHPSETLTPLVTWGAGIKYPQRVSAQQ FDDAFLKEWRLENWKRLDVNQADIAPLMTSLIGVPFPLNSVGILPVDYLNNTDLFKAESM FTNAVQILEQFKVKMTQKKEVTLPFLFTPFKLLSDSKQFNILRKARSYIKHRKFDEVVSL CKELIHLALKGLSYYHTYDRFFLGVNVVIGFVGWISYASLLIIKSHSNLIKGVSKEVKKP SHLLPCSFVAIGILVAFFLLIQACPWTYYVYGLLPLPIWYAVLREFQVIQDLVVSVLTYP LSHFVGYLLAFTLGIEVLVLSFFYRYMLTAGLTAFAAWPFLTRLWTRAKMTSLSWTFFSL LLAVFPLMPVVGRKPDISLVMGAGLLVLLLSLCVVTSLMKRKDSFIKEELLVHLLQVLST VLSMYVVYSTQSSLLRKQGLPLMNQIISWATLASSLVVPLLSSPVLFQRLFSILLSLMST YLLLSTGYEALFPLVLSCLMFVWINIEQETLQQSGVCCKQKLTSIQFSYNTDITQFRQLY LDDIRRAFFLVFFLVTAFFGTGNIASINSFDLASVYCFLTVFSPFMMGALMMWKILIPFV LVMCAFEAVQLTTQLSSKSLFLIVLVISDIMALHFFFLVKDYGSWLDIGTSISHYVIVMS MTIFLVFLNGLAQLLTTKKLRLCGKPKSHFM ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ coiled coil prediction for NP_036459.1 sequence: 931 amino acids, 0 residue(s) in coiled coil state . | . | . | . | . | . 60 MLLFFTLGLL IHFVFFASIF DIYFTSPLVH GMTPQFTPLP PPARRLVLFV ADGLRADALY ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 -w border ---------- ---------- ---------- ---------- ---------- ---------- * 21 M'95 -w register ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 +w polar ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 MTK -w class ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 28 M'95 -w signif. ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 14 M'95 -w local . | . | . | . | . | . 120 ELDENGNSRA PFIRNIIMHE GSWGISHTRV PTESRPGHVA LIAGFYEDVS AVAKGWKENP ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 -w border ---------- ---------- ---------- ---------- ---------- ---------- * 21 M'95 -w register ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 +w polar ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 MTK -w class ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 28 M'95 -w signif. ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 14 M'95 -w local . | . | . | . | . | . 180 VEFDSLFNES KYTWSWGSPD ILPMFAKGAS GDHVYTYSYD AKREDFGAQD ATKLDTWVFD ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 -w border ---------- ---------- ---------- ---------- ---------- ---------- * 21 M'95 -w register ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 +w polar ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 MTK -w class ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 28 M'95 -w signif. ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 14 M'95 -w local . | . | . | . | . | . 240 NVKDFFHHAR NNQSLFSKIN EEKIVFFLHL LGIDTNGHAH RPSSRDYKHN IKKVDDGVKE ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 -w border ---------- ---------- ---------- ---------- ---------- ---------- * 21 M'95 -w register ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 +w polar ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 MTK -w class ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 28 M'95 -w signif. ~~~~~~~~~1 1111111111 111~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 14 M'95 -w local . | . | . | . | . | . 300 IVSMFNHFYG NDGKTTFIFT SDHGMTDWGS HGAGHPSETL TPLVTWGAGI KYPQRVSAQQ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 -w border ---------- ---------- ---------- ---------- ---------- ---------- * 21 M'95 -w register ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 +w polar ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 MTK -w class ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 28 M'95 -w signif. ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 14 M'95 -w local . | . | . | . | . | . 360 FDDAFLKEWR LENWKRLDVN QADIAPLMTS LIGVPFPLNS VGILPVDYLN NTDLFKAESM ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 -w border ---------- ---------- ---------- ---------- ---------- ---------- * 21 M'95 -w register ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 +w polar ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 MTK -w class ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 28 M'95 -w signif. ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 14 M'95 -w local . | . | . | . | . | . 420 FTNAVQILEQ FKVKMTQKKE VTLPFLFTPF KLLSDSKQFN ILRKARSYIK HRKFDEVVSL ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 -w border ---------- ---------- ---------- ---------- ---------- ---------- * 21 M'95 -w register ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 +w polar ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 MTK -w class ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 28 M'95 -w signif. ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 14 M'95 -w local . | . | . | . | . | . 480 CKELIHLALK GLSYYHTYDR FFLGVNVVIG FVGWISYASL LIIKSHSNLI KGVSKEVKKP ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 -w border ---------- ---------- ---------- ---------- ---------- ---------- * 21 M'95 -w register ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 +w polar ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 MTK -w class ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 28 M'95 -w signif. ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 14 M'95 -w local . | . | . | . | . | . 540 SHLLPCSFVA IGILVAFFLL IQACPWTYYV YGLLPLPIWY AVLREFQVIQ DLVVSVLTYP ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 -w border ---------- ---------- ---------- ---------- ---------- ---------- * 21 M'95 -w register ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 +w polar ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 MTK -w class ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 28 M'95 -w signif. ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 14 M'95 -w local . | . | . | . | . | . 600 LSHFVGYLLA FTLGIEVLVL SFFYRYMLTA GLTAFAAWPF LTRLWTRAKM TSLSWTFFSL ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 -w border ---------- ---------- ---------- ---------- ---------- ---------- * 21 M'95 -w register ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 +w polar ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 MTK -w class ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 28 M'95 -w signif. ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 14 M'95 -w local . | . | . | . | . | . 660 LLAVFPLMPV VGRKPDISLV MGAGLLVLLL SLCVVTSLMK RKDSFIKEEL LVHLLQVLST ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 -w border ---------- ---------- ---------- ---------- ---------- ---------- * 21 M'95 -w register ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 +w polar ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 MTK -w class ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 28 M'95 -w signif. ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 14 M'95 -w local . | . | . | . | . | . 720 VLSMYVVYST QSSLLRKQGL PLMNQIISWA TLASSLVVPL LSSPVLFQRL FSILLSLMST ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 -w border ---------- ---------- ---------- ---------- ---------- ---------- * 21 M'95 -w register ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 +w polar ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 MTK -w class ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 28 M'95 -w signif. ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 14 M'95 -w local . | . | . | . | . | . 780 YLLLSTGYEA LFPLVLSCLM FVWINIEQET LQQSGVCCKQ KLTSIQFSYN TDITQFRQLY ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 -w border ---------- ---------- ---------- ---------- ---------- ---------- * 21 M'95 -w register ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 +w polar ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 MTK -w class ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 28 M'95 -w signif. ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 14 M'95 -w local . | . | . | . | . | . 840 LDDIRRAFFL VFFLVTAFFG TGNIASINSF DLASVYCFLT VFSPFMMGAL MMWKILIPFV ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 -w border ---------- ---------- ---------- ---------- ---------- ---------- * 21 M'95 -w register ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 +w polar ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 MTK -w class ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 28 M'95 -w signif. ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 14 M'95 -w local . | . | . | . | . | . 900 LVMCAFEAVQ LTTQLSSKSL FLIVLVISDI MALHFFFLVK DYGSWLDIGT SISHYVIVMS ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 -w border ---------- ---------- ---------- ---------- ---------- ---------- * 21 M'95 -w register ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 +w polar ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 MTK -w class ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 28 M'95 -w signif. ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 14 M'95 -w local . | . | . | MTIFLVFLNG LAQLLTTKKL RLCGKPKSHF M ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~ ---------- ---------- ---------- - ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ prediction of transmembrane regions with toppred2 *********************************** *TOPPREDM with eukaryotic function* *********************************** NP_036459.1.fa.___inter___ is a single sequence Using hydrophobicity file: /bio_software/2D/toppredm/lib/Engelman-Steitz.scale Using cyt/ext file: /bio_software/2D/toppredm/lib/Cyt-Ext.prok Using sequence file: NP_036459.1.fa.___inter___ (1 sequences) MLLFFTLGLLIHFVFFASIFDIYFTSPLVHGMTPQFTPLPPPARRLVLFV ADGLRADALYELDENGNSRAPFIRNIIMHEGSWGISHTRVPTESRPGHVA LIAGFYEDVSAVAKGWKENPVEFDSLFNESKYTWSWGSPDILPMFAKGAS GDHVYTYSYDAKREDFGAQDATKLDTWVFDNVKDFFHHARNNQSLFSKIN EEKIVFFLHLLGIDTNGHAHRPSSRDYKHNIKKVDDGVKEIVSMFNHFYG NDGKTTFIFTSDHGMTDWGSHGAGHPSETLTPLVTWGAGIKYPQRVSAQQ FDDAFLKEWRLENWKRLDVNQADIAPLMTSLIGVPFPLNSVGILPVDYLN NTDLFKAESMFTNAVQILEQFKVKMTQKKEVTLPFLFTPFKLLSDSKQFN ILRKARSYIKHRKFDEVVSLCKELIHLALKGLSYYHTYDRFFLGVNVVIG FVGWISYASLLIIKSHSNLIKGVSKEVKKPSHLLPCSFVAIGILVAFFLL IQACPWTYYVYGLLPLPIWYAVLREFQVIQDLVVSVLTYPLSHFVGYLLA FTLGIEVLVLSFFYRYMLTAGLTAFAAWPFLTRLWTRAKMTSLSWTFFSL LLAVFPLMPVVGRKPDISLVMGAGLLVLLLSLCVVTSLMKRKDSFIKEEL LVHLLQVLSTVLSMYVVYSTQSSLLRKQGLPLMNQIISWATLASSLVVPL LSSPVLFQRLFSILLSLMSTYLLLSTGYEALFPLVLSCLMFVWINIEQET LQQSGVCCKQKLTSIQFSYNTDITQFRQLYLDDIRRAFFLVFFLVTAFFG TGNIASINSFDLASVYCFLTVFSPFMMGALMMWKILIPFVLVMCAFEAVQ LTTQLSSKSLFLIVLVISDIMALHFFFLVKDYGSWLDIGTSISHYVIVMS MTIFLVFLNGLAQLLTTKKLRLCGKPKSHFM (p)rokaryotic or (e)ukaryotic: e Charge-pair energy: 0 Length of full window (odd number!): 21 Length of core window (odd number!): 11 Number of residues to add to each end of helix: 1 Critical length: 60 Upper cutoff for candidates: 1 Lower cutoff for candidates: 0.6 Total of 4 structures are to be tested Candidate membrane-spanning segments: Helix Begin End Score Certainity 1 1 21 2.240 Certain 2 24 44 0.625 Putative 3 326 346 1.410 Certain 4 443 463 1.724 Certain 5 483 503 2.330 Certain 6 506 526 0.891 Putative 7 544 564 1.633 Certain 8 567 587 1.051 Certain 9 592 612 2.221 Certain 10 617 637 2.218 Certain 11 650 670 1.415 Certain 12 686 706 1.674 Certain 13 726 746 1.706 Certain 14 787 807 2.073 Certain 15 813 833 2.230 Certain 16 836 856 1.101 Certain 17 859 879 1.656 Certain 18 892 912 2.026 Certain ---------------------------------------------------------------------- Structure 1 Transmembrane segments included in this structure: Segment 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 Loop length 0 2 281 96 19 2 17 2 4 4 12 15 19 40 5 2 2 12 19 K+R profile 1.00 + 5.00 1.00 3.00 4.00 1.00 0.00 1.00 5.00 0.00 + 0.00 1.00 2.00 2.00 5.00 1.00 1.00 CYT-EXT prof - 0.88 - - - - - - - - - 0.25 - - - - - - - For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: 9.00 Tm probability: 0.05 -> Orientation: N-in Charge-difference over N-terminal Tm (+-15 residues): 1.00 (NEG-POS)/(NEG+POS): 0.0000 NEG: 0.0000 POS: 0.0000 -> Orientation: N-in CYT-EXT difference: 0.63 -> Orientation: N-out ---------------------------------------------------------------------- Structure 2 Transmembrane segments included in this structure: Segment 1 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 Loop length 0 304 96 19 2 17 2 4 4 12 15 19 40 5 2 2 12 19 K+R profile 1.00 + 0.00 1.00 2.00 2.00 5.00 1.00 1.00 + 5.00 1.00 3.00 4.00 1.00 0.00 1.00 5.00 CYT-EXT prof - 0.25 - - - - - - - 0.99 - - - - - - - - For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: -7.00 Tm probability: 0.73 -> Orientation: N-out Charge-difference over N-terminal Tm (+-15 residues): 1.00 (NEG-POS)/(NEG+POS): 0.0000 NEG: 0.0000 POS: 0.0000 -> Orientation: N-in CYT-EXT difference: -0.75 -> Orientation: N-in ---------------------------------------------------------------------- Structure 3 Transmembrane segments included in this structure: Segment 1 2 3 4 5 7 8 9 10 11 12 13 14 15 16 17 18 Loop length 0 2 281 96 19 40 2 4 4 12 15 19 40 5 2 2 12 19 K+R profile 1.00 + 5.00 1.00 2.00 2.00 5.00 1.00 1.00 0.00 + 1.00 3.00 4.00 1.00 0.00 1.00 5.00 CYT-EXT prof - 0.88 - - - - - - - - 0.25 - - - - - - - For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: 3.00 Tm probability: 0.06 -> Orientation: N-in Charge-difference over N-terminal Tm (+-15 residues): 1.00 (NEG-POS)/(NEG+POS): 0.0000 NEG: 0.0000 POS: 0.0000 -> Orientation: N-in CYT-EXT difference: 0.63 -> Orientation: N-out ---------------------------------------------------------------------- Structure 4 Transmembrane segments included in this structure: Segment 1 3 4 5 7 8 9 10 11 12 13 14 15 16 17 18 Loop length 0 304 96 19 40 2 4 4 12 15 19 40 5 2 2 12 19 K+R profile 1.00 + 1.00 3.00 4.00 1.00 0.00 1.00 5.00 + 5.00 1.00 2.00 2.00 5.00 1.00 1.00 CYT-EXT prof - 0.25 - - - - - - - 0.99 - - - - - - - For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: -1.00 Tm probability: 1.00 -> Orientation: N-out Charge-difference over N-terminal Tm (+-15 residues): 1.00 (NEG-POS)/(NEG+POS): 0.0000 NEG: 0.0000 POS: 0.0000 -> Orientation: N-in CYT-EXT difference: -0.75 -> Orientation: N-in ---------------------------------------------------------------------- "NP_036459" 931 1 21 #t 2.23958 24 44 #f 0.625 326 346 #t 1.41042 443 463 #t 1.72396 483 503 #t 2.33021 506 526 #f 0.890625 544 564 #t 1.63333 567 587 #t 1.05104 592 612 #t 2.22083 617 637 #t 2.21771 650 670 #t 1.41458 686 706 #t 1.67396 726 746 #t 1.70625 787 807 #t 2.07292 813 833 #t 2.23021 836 856 #t 1.10104 859 879 #t 1.65625 892 912 #t 2.02604 ************************************ *TOPPREDM with prokaryotic function* ************************************ NP_036459.1.fa.___inter___ is a single sequence Using hydrophobicity file: /bio_software/2D/toppredm/lib/Engelman-Steitz.scale Using cyt/ext file: /bio_software/2D/toppredm/lib/Cyt-Ext.prok Using sequence file: NP_036459.1.fa.___inter___ (1 sequences) MLLFFTLGLLIHFVFFASIFDIYFTSPLVHGMTPQFTPLPPPARRLVLFV ADGLRADALYELDENGNSRAPFIRNIIMHEGSWGISHTRVPTESRPGHVA LIAGFYEDVSAVAKGWKENPVEFDSLFNESKYTWSWGSPDILPMFAKGAS GDHVYTYSYDAKREDFGAQDATKLDTWVFDNVKDFFHHARNNQSLFSKIN EEKIVFFLHLLGIDTNGHAHRPSSRDYKHNIKKVDDGVKEIVSMFNHFYG NDGKTTFIFTSDHGMTDWGSHGAGHPSETLTPLVTWGAGIKYPQRVSAQQ FDDAFLKEWRLENWKRLDVNQADIAPLMTSLIGVPFPLNSVGILPVDYLN NTDLFKAESMFTNAVQILEQFKVKMTQKKEVTLPFLFTPFKLLSDSKQFN ILRKARSYIKHRKFDEVVSLCKELIHLALKGLSYYHTYDRFFLGVNVVIG FVGWISYASLLIIKSHSNLIKGVSKEVKKPSHLLPCSFVAIGILVAFFLL IQACPWTYYVYGLLPLPIWYAVLREFQVIQDLVVSVLTYPLSHFVGYLLA FTLGIEVLVLSFFYRYMLTAGLTAFAAWPFLTRLWTRAKMTSLSWTFFSL LLAVFPLMPVVGRKPDISLVMGAGLLVLLLSLCVVTSLMKRKDSFIKEEL LVHLLQVLSTVLSMYVVYSTQSSLLRKQGLPLMNQIISWATLASSLVVPL LSSPVLFQRLFSILLSLMSTYLLLSTGYEALFPLVLSCLMFVWINIEQET LQQSGVCCKQKLTSIQFSYNTDITQFRQLYLDDIRRAFFLVFFLVTAFFG TGNIASINSFDLASVYCFLTVFSPFMMGALMMWKILIPFVLVMCAFEAVQ LTTQLSSKSLFLIVLVISDIMALHFFFLVKDYGSWLDIGTSISHYVIVMS MTIFLVFLNGLAQLLTTKKLRLCGKPKSHFM (p)rokaryotic or (e)ukaryotic: p Charge-pair energy: 0 Length of full window (odd number!): 21 Length of core window (odd number!): 11 Number of residues to add to each end of helix: 1 Critical length: 60 Upper cutoff for candidates: 1 Lower cutoff for candidates: 0.6 Total of 4 structures are to be tested Candidate membrane-spanning segments: Helix Begin End Score Certainity 1 1 21 2.240 Certain 2 24 44 0.625 Putative 3 326 346 1.410 Certain 4 443 463 1.724 Certain 5 483 503 2.330 Certain 6 506 526 0.891 Putative 7 544 564 1.633 Certain 8 567 587 1.051 Certain 9 592 612 2.221 Certain 10 617 637 2.218 Certain 11 650 670 1.415 Certain 12 686 706 1.674 Certain 13 726 746 1.706 Certain 14 787 807 2.073 Certain 15 813 833 2.230 Certain 16 836 856 1.101 Certain 17 859 879 1.656 Certain 18 892 912 2.026 Certain ---------------------------------------------------------------------- Structure 1 Transmembrane segments included in this structure: Segment 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 Loop length 0 2 281 96 19 2 17 2 4 4 12 15 19 40 5 2 2 12 19 K+R profile 0.00 + 5.00 1.00 3.00 4.00 1.00 0.00 1.00 5.00 0.00 + 0.00 1.00 2.00 2.00 5.00 1.00 1.00 CYT-EXT prof - 0.88 - - - - - - - - - 0.25 - - - - - - - For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: 8.00 Tm probability: 0.05 -> Orientation: N-in Charge-difference over N-terminal Tm (+-15 residues): 1.00 (NEG-POS)/(NEG+POS): 0.0000 NEG: 0.0000 POS: 0.0000 -> Orientation: N-in CYT-EXT difference: 0.63 -> Orientation: N-out ---------------------------------------------------------------------- Structure 2 Transmembrane segments included in this structure: Segment 1 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 Loop length 0 304 96 19 2 17 2 4 4 12 15 19 40 5 2 2 12 19 K+R profile 0.00 + 0.00 1.00 2.00 2.00 5.00 1.00 1.00 + 5.00 1.00 3.00 4.00 1.00 0.00 1.00 5.00 CYT-EXT prof - 0.25 - - - - - - - 0.99 - - - - - - - - For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: -8.00 Tm probability: 0.73 -> Orientation: N-out Charge-difference over N-terminal Tm (+-15 residues): 1.00 (NEG-POS)/(NEG+POS): 0.0000 NEG: 0.0000 POS: 0.0000 -> Orientation: N-in CYT-EXT difference: -0.75 -> Orientation: N-in ---------------------------------------------------------------------- Structure 3 Transmembrane segments included in this structure: Segment 1 2 3 4 5 7 8 9 10 11 12 13 14 15 16 17 18 Loop length 0 2 281 96 19 40 2 4 4 12 15 19 40 5 2 2 12 19 K+R profile 0.00 + 5.00 1.00 2.00 2.00 5.00 1.00 1.00 0.00 + 1.00 3.00 4.00 1.00 0.00 1.00 5.00 CYT-EXT prof - 0.88 - - - - - - - - 0.25 - - - - - - - For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: 2.00 Tm probability: 0.06 -> Orientation: N-in Charge-difference over N-terminal Tm (+-15 residues): 1.00 (NEG-POS)/(NEG+POS): 0.0000 NEG: 0.0000 POS: 0.0000 -> Orientation: N-in CYT-EXT difference: 0.63 -> Orientation: N-out ---------------------------------------------------------------------- Structure 4 Transmembrane segments included in this structure: Segment 1 3 4 5 7 8 9 10 11 12 13 14 15 16 17 18 Loop length 0 304 96 19 40 2 4 4 12 15 19 40 5 2 2 12 19 K+R profile 0.00 + 1.00 3.00 4.00 1.00 0.00 1.00 5.00 + 5.00 1.00 2.00 2.00 5.00 1.00 1.00 CYT-EXT prof - 0.25 - - - - - - - 0.99 - - - - - - - For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: -2.00 Tm probability: 1.00 -> Orientation: N-out Charge-difference over N-terminal Tm (+-15 residues): 1.00 (NEG-POS)/(NEG+POS): 0.0000 NEG: 0.0000 POS: 0.0000 -> Orientation: N-in CYT-EXT difference: -0.75 -> Orientation: N-in ---------------------------------------------------------------------- "NP_036459" 931 1 21 #t 2.23958 24 44 #f 0.625 326 346 #t 1.41042 443 463 #t 1.72396 483 503 #t 2.33021 506 526 #f 0.890625 544 564 #t 1.63333 567 587 #t 1.05104 592 612 #t 2.22083 617 637 #t 2.21771 650 670 #t 1.41458 686 706 #t 1.67396 726 746 #t 1.70625 787 807 #t 2.07292 813 833 #t 2.23021 836 856 #t 1.10104 859 879 #t 1.65625 892 912 #t 2.02604 ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ SAPS. Version of April 11, 1996. Date run: Wed May 15 16:54:38 2002 File: /people/b_eisen/NP_036459.1.fa.___saps___ ID NP_036459.1 DE phosphatidylinositol glycan, class N; [Homo sapiens]. number of residues: 931; molecular weight: 105.8 kdal 1 MLLFFTLGLL IHFVFFASIF DIYFTSPLVH GMTPQFTPLP PPARRLVLFV ADGLRADALY 61 ELDENGNSRA PFIRNIIMHE GSWGISHTRV PTESRPGHVA LIAGFYEDVS AVAKGWKENP 121 VEFDSLFNES KYTWSWGSPD ILPMFAKGAS GDHVYTYSYD AKREDFGAQD ATKLDTWVFD 181 NVKDFFHHAR NNQSLFSKIN EEKIVFFLHL LGIDTNGHAH RPSSRDYKHN IKKVDDGVKE 241 IVSMFNHFYG NDGKTTFIFT SDHGMTDWGS HGAGHPSETL TPLVTWGAGI KYPQRVSAQQ 301 FDDAFLKEWR LENWKRLDVN QADIAPLMTS LIGVPFPLNS VGILPVDYLN NTDLFKAESM 361 FTNAVQILEQ FKVKMTQKKE VTLPFLFTPF KLLSDSKQFN ILRKARSYIK HRKFDEVVSL 421 CKELIHLALK GLSYYHTYDR FFLGVNVVIG FVGWISYASL LIIKSHSNLI KGVSKEVKKP 481 SHLLPCSFVA IGILVAFFLL IQACPWTYYV YGLLPLPIWY AVLREFQVIQ DLVVSVLTYP 541 LSHFVGYLLA FTLGIEVLVL SFFYRYMLTA GLTAFAAWPF LTRLWTRAKM TSLSWTFFSL 601 LLAVFPLMPV VGRKPDISLV MGAGLLVLLL SLCVVTSLMK RKDSFIKEEL LVHLLQVLST 661 VLSMYVVYST QSSLLRKQGL PLMNQIISWA TLASSLVVPL LSSPVLFQRL FSILLSLMST 721 YLLLSTGYEA LFPLVLSCLM FVWINIEQET LQQSGVCCKQ KLTSIQFSYN TDITQFRQLY 781 LDDIRRAFFL VFFLVTAFFG TGNIASINSF DLASVYCFLT VFSPFMMGAL MMWKILIPFV 841 LVMCAFEAVQ LTTQLSSKSL FLIVLVISDI MALHFFFLVK DYGSWLDIGT SISHYVIVMS 901 MTIFLVFLNG LAQLLTTKKL RLCGKPKSHF M -------------------------------------------------------------------------------- COMPOSITIONAL ANALYSIS (extremes relative to: swp23s) A : 52( 5.6%); C : 10( 1.1%); D : 40( 4.3%); E : 29( 3.1%); F+ : 78( 8.4%) G : 49( 5.3%); H : 26( 2.8%); I : 55( 5.9%); K : 49( 5.3%); L+ :132(14.2%) M : 27( 2.9%); N : 28( 3.0%); P : 39( 4.2%); Q : 29( 3.1%); R : 30( 3.2%) S : 78( 8.4%); T : 53( 5.7%); V : 75( 8.1%); W : 19( 2.0%); Y : 33( 3.5%) KR : 79 ( 8.5%); ED : 69 ( 7.4%); AGP : 140 ( 15.0%); KRED : 148 ( 15.9%); KR-ED : 10 ( 1.1%); FIKMNY : 270 ( 29.0%); LVIFM + : 367 ( 39.4%); ST : 131 ( 14.1%). -------------------------------------------------------------------------------- CHARGE DISTRIBUTIONAL ANALYSIS 1 0000000000 0000000000 -000000000 0000000000 000++00000 0-00+0-000 61 -0--0000+0 000+00000- 00000000+0 00-0+00000 000000--00 000+00+-00 121 0-0-0000-0 +00000000- 000000+000 0-0000000- 0++--0000- 00+0-0000- 181 00+-00000+ 0000000+00 --+0000000 000-000000 +000+-0+00 0++0--00+- 241 0000000000 0-0+000000 0-0000-000 0000000-00 0000000000 +000+00000 301 0--000+-0+ 0-00++0-00 00-0000000 0000000000 000000-000 00-00+0-00 361 00000000-0 0+0+000++- 0000000000 +000-0+000 00++0+000+ 0++0--0000 421 0+-000000+ 00000000-+ 0000000000 0000000000 000+000000 +000+-0++0 481 0000000000 0000000000 0000000000 0000000000 000+-00000 -000000000 541 0000000000 00000-0000 0000+00000 0000000000 00+000+0+0 0000000000 601 0000000000 00++0-0000 0000000000 000000000+ ++-000+--0 0000000000 661 0000000000 00000++000 0000000000 0000000000 00000000+0 0000000000 721 00000000-0 0000000000 000000-0-0 00000000+0 +000000000 0-0000+000 781 0--0++0000 0000000000 0000000000 -000000000 0000000000 000+000000 841 000000-000 0000000+00 00000000-0 000000000+ -00000-000 0000000000 901 0000000000 0000000++0 +000+0+000 0 A. CHARGE CLUSTERS. Positive charge clusters (cmin = 9/30 or 12/45 or 14/60): none Negative charge clusters (cmin = 8/30 or 11/45 or 13/60): none Mixed charge clusters (cmin = 13/30 or 18/45 or 22/60): none B. HIGH SCORING (UN)CHARGED SEGMENTS. There are no high scoring positive charge segments. There are no high scoring negative charge segments. There are no high scoring mixed charge segments. There are no high scoring uncharged segments. C. CHARGE RUNS AND PATTERNS. pattern (+)| (-)| (*)| (0)| (+0)| (-0)| (*0)|(+00)|(-00)|(*00)| (H.)|(H..)| lmin0 5 | 4 | 6 | 55 | 9 | 9 | 12 | 12 | 11 | 15 | 7 | 9 | lmin1 6 | 6 | 8 | 67 | 11 | 11 | 15 | 14 | 14 | 18 | 9 | 12 | lmin2 7 | 7 | 9 | 75 | 13 | 12 | 16 | 16 | 16 | 20 | 10 | 13 | (Significance level: 0.010000; Minimal displayed length: 6) There are no charge runs or patterns exceeding the given minimal lengths. Run count statistics: + runs >= 3: 1, at 640; - runs >= 3: 0 * runs >= 4: 2, at 162; 640; 0 runs >= 37: 1, at 480; -------------------------------------------------------------------------------- DISTRIBUTION OF OTHER AMINO ACID TYPES 1. HIGH SCORING SEGMENTS. __________________________________ High scoring hydrophobic segments: 2.00 (LVIFM) 1.00 (AGYCW) 0.00 (BZX) -2.00 (PH) -4.00 (STNQ) -8.00 (KEDR) Expected score/letter: -1.256 M_0.01= 40.57; M_0.05= 33.67 1) From 488 to 523: length= 36, score=35.00 * 488 FVAIGILVAF FLLIQACPWT YYVYGLLPLP IWYAVL L: 7(19.4%); A: 4(11.1%); V: 4(11.1%); I: 4(11.1%); Y: 4(11.1%); ____________________________________ High scoring transmembrane segments: 5.00 (LVIF) 2.00 (AGM) 0.00 (BZX) -1.00 (YCW) -2.00 (ST) -6.00 (P) -8.00 (H) -10.00 (NQ) -16.00 (KR) -17.00 (ED) Expected score/letter: -1.952 M_0.01= 111.5; M_0.05= 91.43; M_0.30= 67.52 1) From 483 to 639: length=157, score=82.00 (pocket at 582 to 616: length= 35, score=-61.00) (pocket at 524 to 531: length= 8, score=-55.00) 483 LLPCSFVAIG ILVAFFLLIQ ACPWTYYVYG LLPLPIWYAV L |REFQVIQD| L 533 VVSVLTYPLS HFVGYLLAFT LGIEVLVLSF FYRYMLTAGL TAFAAWPFL |T 583 RLWTRAKMTS LSWTFFSLLL AVFPLMPVVG RKPD| ISLVMG AGLLVLLLSL 633 CVVTSLM L: 34(21.7%); V: 18(11.5%); 2) From 787 to 879: length= 93, score=96.00 * (pocket at 847 to 859: length= 13, score=-46.00) (pocket at 808 to 811: length= 4, score=-24.00) 787 AFFLVFFLVT AFFGTGNIAS I |NSFD| LASVY CFLTVFSPFM MGALMMWKIL 837 IPFVLVMCAF |EAVQLTTQLS SKS| LFLIVLV ISDIMALHFF FLV L: 14(15.1%); V: 10(10.8%); F: 16(17.2%); 2. SPACINGS OF C. H2N-420-C-64-C-17-C-128-C-104-C-18-C-C-58-C-26-C-78-C-8-COOH 2*. SPACINGS OF C and H. (additional deluxe function for ALEX) H2N-11-H-17-H-48-H-7-H-10-H-54-H-33-H-H-20-H-8-H-1-H-8-H-17-H-15-H-7-H-3-H-135-H-9-C-4-H-9-H-29-H-15-H-3-C-17-C-38-H-89-C-19-H-84-C-18-C-C-58-C-26-C-29-H-19-H-28-C-5-H-2-COOH -------------------------------------------------------------------------------- REPETITIVE STRUCTURES. A. SEPARATED, TANDEM, AND PERIODIC REPEATS: amino acid alphabet. Repeat core block length: 5 B. SEPARATED AND TANDEM REPEATS: 11-letter reduced alphabet. (i= LVIF; += KR; -= ED; s= AG; o= ST; n= NQ; a= YW; p= P; h= H; m= M; c= C) Repeat core block length: 9 Aligned matching blocks: [ 4- 5]-( 3)-[ 9- 26] [ 645- 646]-( 3)-[ 650- 670] [ 9- 26] iiihii_iisoii-iai__oo [ 650- 670] iiihiiniiooiiomaiiaoo with superset: [ 10- 18] iihiiiiso [ 553- 561] isi-iiiio [ 628- 636] iiioiciio [ 651- 659] iihiiniio [ 788- 796] iiiiiiiio [ 860- 868] iiiiiiiio and: [ 10- 20] iihiiiisoii [ 553- 563] isi-iiiioii [ 651- 662] iihiiniiooii [ 788- 799] iiiiiiiiosii -------------------------------------------------------------------------------- MULTIPLETS. A. AMINO ACID ALPHABET. 1. Total number of amino acid multiplets: 72 (Expected range: 34-- 79) 2. Histogram of spacings between consecutive amino acid multiplets: (1-5) 35 (6-10) 7 (11-20) 20 (>=21) 11 3. Clusters of amino acid multiplets (cmin = 13/30 or 16/45 or 20/60): none B. CHARGE ALPHABET. 1. Total number of charge multiplets: 22 (Expected range: 1-- 21) high 13 +plets (f+: 8.5%), 9 -plets (f-: 7.4%) Total number of charge altplets: 15 (Critical number: 24) 2. Histogram of spacings between consecutive charge multiplets: (1-5) 4 (6-10) 2 (11-20) 3 (>=21) 14 -------------------------------------------------------------------------------- PERIODICITY ANALYSIS. A. AMINO ACID ALPHABET (core: 4; !-core: 5) Location Period Element Copies Core Errors 160- 184 5 D.... 5 5 ! 0 514- 549 9 L........ 4 4 0 626- 633 2 L. 4 4 0 650- 665 4 L... 4 4 0 710- 737 7 L....L. 4 4 /0/././././1/./ 905- 916 3 L.. 4 4 0 B. CHARGE ALPHABET ({+= KR; -= ED; 0}; core: 5; !-core: 6) and HYDROPHOBICITY ALPHABET ({*= KRED; i= LVIF; 0}; core: 6; !-core:10) Location Period Element Copies Core Errors 1- 16 2 i. 8 8 0 1- 24 3 i.. 8 8 0 4- 63 5 i...0 10 6 /2/./././4/ 16- 39 4 i000 6 6 /0/2/1/2/ 160- 184 5 -00.. 5 5 /0/0/1/././ 343- 378 6 i.00.. 6 6 /0/./2/2/././ 385- 456 8 i....... 8 6 1 441- 452 2 i. 6 6 0 442- 504 7 i...0.. 8 6 /1/./././3/././ 489- 502 2 i. 7 7 0 529- 560 4 i0.. 8 8 /0/2/././ 548- 646 9 i...0.... 10 8 /1/./././2/././././ 549- 560 2 i. 6 6 0 625- 630 1 i 6 6 0 626- 689 4 i... 13 6 3 652- 669 3 i0. 6 6 /0/1/./ 687- 749 9 i......0. 7 7 /0/././././././1/./ 731- 760 5 i.0.0 6 6 /0/./0/./2/ 779- 808 5 i.... 6 6 0 788- 795 1 i 8 8 0 819- 881 3 i.. 17 7 4 821- 915 5 i.... 16 7 3 860- 867 1 i 8 8 0 896- 908 1 i 11 6 2 -------------------------------------------------------------------------------- SPACING ANALYSIS. Location (Quartile) Spacing Rank P-value Interpretation 62- 101 (1.) L( 39)L 2 of 133 0.0296 large 2. maximal spacing 211- 280 (2.) L( 69)L 1 of 133 0.0022 large 1. maximal spacing 272- 274 (2.) G( 2)G 50 of 50 0.0038 large minimal spacing 287- 289 (2.) G( 2)G 47 of 50 0.0038 matching minimum 622- 624 (3.) G( 2)G 48 of 50 0.0038 matching minimum 800- 802 (4.) G( 2)G 49 of 50 0.0038 matching minimum ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ Start with Pfam (from /data/patterns/pfam) hmmpfam - search a single seq against HMM database HMMER 2.1.1 (Dec 1998) Copyright (C) 1992-1998 Washington University School of Medicine HMMER is freely distributed under the GNU General Public License (GPL). - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /data/patterns/pfam/Pfam Sequence file: NP_036459.1.fa - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: NP_036459.1 phosphatidylinositol glycan, class N; [Homo sapiens]. Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Ribosomal_L14 Ribosomal protein L14p/L23e 2.2 30 1 CAT Chloramphenicol acetyltransferase 0.0 99 1 cytochrome_b_N Cytochrome b(N-terminal)/b6/petB -0.5 68 1 ART NAD:arginine ADP-ribosyltransferase -0.8 77 1 Rhabd_glycop Rhabdovirus spike glycoprotein -1.8 73 1 DUF6 Integral membrane protein DUF6 -16.5 3 1 ion_trans Ion transport protein -22.3 44 1 Abi CAAX amino terminal protease family -32.2 20 1 Papilloma_E5 Papillomavirus E5 -44.9 48 1 Metalloenzyme Metalloenzyme superfamily -46.0 15 1 ExbD Biopolymer transport protein ExbD/Tol -52.1 40 1 Sdh_cyt Succinate dehydrogenase cytochrome b -55.4 7.7 1 DsbB Disulfide bond formation protein DsbB -56.9 48 1 DUF56 Integral membrane protein DUF56 -57.7 12 1 Cation_ATPase_C Cation transporting ATPase, C-terminu -58.2 69 1 DAGK_prokar Prokaryotic diacylglycerol kinase -62.4 73 1 oxidored_q5_N NADH-ubiquinone oxidoreductase chain -63.8 22 1 MgtE Divalent cation transporter -64.4 55 1 DUF216 Domain of unknown function DUF -70.4 78 1 BioY BioY family -71.8 48 1 BRO1 BRO1-like domain -87.3 1e+02 1 oxidored_q3 NADH-ubiquinone/plastoquinone oxidore -88.0 14 1 Sterol_desat Sterol desaturase -90.2 11 1 Steroid_dh 3-oxo-5-alpha-steroid 4-dehydrogenase -90.3 42 1 Isochorismatase Isochorismatase family -90.9 82 1 UbiA UbiA prenyltransferase family -104.4 30 1 BPD_transp_2 Branched-chain amino acid transport s -122.5 5.9 1 DUF205 Domain of unknown function DUF -132.5 98 1 UPF0118 Domain of unknown function DUF20 -134.4 9.9 1 UPF0056 Uncharacterised protein family UPF005 -138.2 78 1 ABC2_membrane ABC-2 type transporter -146.9 39 1 Sulfatase Sulfatase -150.4 5.8 1 Phosphodiest Type I phosphodiesterase / nucleotide -154.8 0.65 1 PTS_EIIC Phosphotransferase system, EIIC -179.4 96 1 xan_ur_permease Permease family -207.7 37 1 Na_H_Exchanger Sodium/hydrogen exchanger family -207.7 54 1 TrkH Sodium transport protein -233.8 47 1 secY eubacterial secY protein -261.3 52 1 MVIN Virulence factor MVIN -272.4 39 1 Herpes_glycop Herpesvirus glycoprotein M -286.7 87 1 Worm_family_8 Putative membrane protein -305.4 61 1 ERG4_ERG24 Ergosterol biosynthesis ERG4/ERG24 fa -328.4 46 1 LacY_symp LacY proton/sugar symporter -362.3 85 1 aa_permeases Amino acid permease -377.9 99 1 UPF0063 Uncharacterized protein family (UPF00 -403.0 88 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Metalloenzyme 1/1 185 302 .. 1 118 [] -46.0 15 Isochorismatase 1/1 199 372 .. 1 212 [] -90.9 82 Phosphodiest 1/1 31 378 .. 1 416 [] -154.8 0.65 Ribosomal_L14 1/1 409 425 .. 117 133 .] 2.2 30 ExbD 1/1 316 431 .. 1 132 [] -52.1 40 Sulfatase 1/1 44 439 .. 1 520 [] -150.4 5.8 Sterol_desat 1/1 318 477 .. 1 242 [] -90.2 11 BRO1 1/1 369 498 .. 1 172 [] -87.3 1e+02 DsbB 1/1 411 540 .. 1 164 [] -56.9 48 oxidored_q3 1/1 436 587 .. 1 177 [] -88.0 14 Rhabd_glycop 1/1 625 648 .. 1 26 [. -1.8 73 ART 1/1 621 651 .. 1 37 [. -0.8 77 UbiA 1/1 445 664 .. 1 290 [] -104.4 30 Abi 1/1 564 664 .. 1 119 [] -32.2 20 DUF216 1/1 544 687 .. 1 208 [] -70.4 78 UPF0063 1/1 209 702 .. 1 777 [] -403.0 88 BPD_transp_2 1/1 424 707 .. 1 370 [] -122.5 5.9 ion_trans 1/1 542 710 .. 1 223 [] -22.3 44 BioY 1/1 578 714 .. 1 186 [] -71.8 48 MgtE 1/1 617 725 .. 1 137 [] -64.4 55 oxidored_q5_N 1/1 650 725 .. 1 110 [] -63.8 22 DUF6 1/1 573 725 .. 1 126 [] -16.5 3 ABC2_membrane 1/1 519 729 .. 1 261 [] -146.9 39 UPF0056 1/1 555 732 .. 1 211 [] -138.2 78 DUF56 1/1 611 739 .. 1 182 [] -57.7 12 Herpes_glycop 1/1 433 749 .. 1 412 [] -286.7 87 Cation_ATPase_C 1/1 613 751 .. 1 193 [] -58.2 69 LacY_symp 1/1 480 761 .. 1 415 [] -362.3 85 Worm_family_8 1/1 537 778 .. 1 404 [] -305.4 61 CAT 1/1 769 786 .. 105 122 .. 0.0 99 ERG4_ERG24 1/1 436 793 .. 1 508 [] -328.4 46 aa_permeases 1/1 490 807 .. 1 498 [] -377.9 99 Steroid_dh 1/1 693 841 .. 1 209 [] -90.3 42 secY 1/1 655 873 .. 1 384 [] -261.3 52 DAGK_prokar 1/1 789 878 .. 1 114 [] -62.4 73 xan_ur_permease 1/1 534 879 .. 1 443 [] -207.7 37 PTS_EIIC 1/1 568 879 .. 1 366 [] -179.4 96 cytochrome_b_N 1/1 861 883 .. 201 222 .] -0.5 68 UPF0118 1/1 594 886 .. 1 340 [] -134.4 9.9 Na_H_Exchanger 1/1 457 890 .. 1 446 [] -207.7 54 Sdh_cyt 1/1 816 908 .. 1 125 [] -55.4 7.7 Papilloma_E5 1/1 835 917 .. 1 74 [] -44.9 48 DUF205 1/1 765 917 .. 1 233 [] -132.5 98 MVIN 1/1 549 926 .. 1 483 [] -272.4 39 TrkH 1/1 540 928 .. 1 491 [] -233.8 47 Alignments of top-scoring domains: Metalloenzyme: domain 1 of 1, from 185 to 302: score -46.0, E = 15 *->emsaaevadklilaieageyDfifvNfanpDamvGHtGdve..akvk a + l + i++++ ++f+++ + D GH+ + ++ ++ NP_036459. 185 FFHHARNNQSLFSKINEEKI-VFFLHLLGID-TNGHAHRPSsrDYKH 229 AiEavDaclgeildal.....ekddglLiiTADHG.NAEpmkgkdkgnph i++vD ++ei++ ++ + + +++i T+DHG ++ ++g NP_036459. 230 NIKKVDDGVKEIVSMFnhfygNDGKTTFIFTSDHGmTDWGSHGAG----- 274 TaHTre.pVPvliygpgvkkdqvggfgefa<-* H e+ P++ +g g+k q+ + + f NP_036459. 275 --HPSEtLTPLVTWGAGIKYPQRVSAQQFD 302 Isochorismatase: domain 1 of 1, from 199 to 372: score -90.9, E = 82 *->iDpqraALLvvDMQnyFvspigeilpe..............ptdevi i+ ++ + +++ + +i+ + + +++++++ +++ +++d+ + NP_036459. 199 INEEKIVFFLH------LLGIDT-NGHahrpssrdykhnikKVDDGV 238 aniqrLkdaArqagiPv..iytaqphdadsqsaldras.vekytalkldr ++i + +++ + ++ i+t +++ + +++ ++ +++ l NP_036459. 239 KEIVSMFNHFYGNDGKTtfIFTSDHG----MTDWGSHGaGHPSETL---- 280 lltdfwGpglnmppedaelvpeLaPqdgDtvltKrrNPLVviYSAFfahv ++ +wG g + + + v+ a+q++D++l+ +r + ++ NP_036459. 281 TPLVTWGAGIK---YP-QRVS--AQQFDDAFLKEWR------LENWK--- 315 cvlnTdLdllLRelGidqLiitGiath.igVlfTalDAfmlgyqvfvveD +l ++q i+ t igV f++++ NP_036459. 316 ------------RLDVNQADIAPLMTSlIGVPFPLNSV------------ 341 AiadfnsdedHeaalryiasrlgavitteeale<-* +i + d+ ++ l+ ++s ++ ++ e++ NP_036459. 342 GILPV--DYLNNTDLFKAESMFTNAVQILEQFK 372 Phosphodiest: domain 1 of 1, from 31 to 378: score -154.8, E = 0.65 *->lsagcanfsaakcpsstfekpPLviliSiDGFRadYlyrfYdtpll. +++++ ++ + Lv+ ++ DG+Rad ly+ d + ++ NP_036459. 31 GMTPQFTPLPPPAR-------RLVL-FVADGLRADALYEL-DENGNs 68 ..pnlhkLa.ecGtsaktsaPymiPsfPTkTFPNHySivTGlYPesHGIv + p +++++ +G++ ++ + +PT++ P+H + G Y++ v NP_036459. 69 raPFIRNIImHEGSWGIS-----HTRVPTESRPGHVALIAGFYED----V 109 gNyffDpklnpeFyF.tlsskesvnNAwesfWwegePiWvtpQseankqg + + +k np F++l + +++ w+ W + + + + + +g NP_036459. 110 SAVAKGWKENPV-EFdSLFNESKYT--WS--WGSPDILPMFA---KGASG 151 vkaAtfFWPG.....sevdyedykieegvfPdiyrPFYFdkynqsvpfke + t+ +++++ + d ++ ++ +vf ++ F+ ++n ++ + NP_036459. 152 DHVYTYSYDAkredfGAQDATKLDT--WVFDNVKD-FFHHARN-NQSLFS 197 Ri..dtilewldlPkdERPqlitlYfeepDhaGHkyGpdseevtkalkev +i++ +i+ l l +D GH++ p s++ ++k+v NP_036459. 198 KIneEKIVFFLHLL-------------GIDTNGHAHRPSSRDYKHNIKKV 234 DgfigqLiegLk..qrnllecvNviiVsDHGMedvpdkkhvylnedlvpl D+ ++ ++ + + + n+++ + +i++sDHGM d ++ +++ NP_036459. 235 DDGVKEIVSMFNhfYGNDGK-TTFIFTSDHGMTDWGSH-----GAGHPSE 278 klietyvgsaarirpmmlpektsPRDfsfnvkeiyanLtckipeegdhfk l +++ a++++p++++ +++ +k NP_036459. 279 TLTPLVTWGAGIKYPQRVSAQQ-------------------FDD--AFLK 307 vylkedlPkRWNlHyakspRvgdivllaepgyaiakeesdkkveKevncg + e+ kR l + ++ + + l +g+ ++ ++ + + + ++ + NP_036459. 308 EWRLENW-KR--LDVNQADIAPLMTSL--IGVPFPLNSVGIL--PVDYLN 350 tsGdHGYD.nnafsDM..ssifigmGPsFknntvvp<-* ++D ++a+s M ++++ i +Fk + + + NP_036459. 351 -----NTDlFKAES-MftNAVQIL--EQFKVKMTQK 378 Ribosomal_L14: domain 1 of 1, from 409 to 425: score 2.2, E = 30 *->lRekgFmkIaSlApeVl<-* ++ ++F ++Sl++e + NP_036459. 409 IKHRKFDEVVSLCKELI 425 ExbD: domain 1 of 1, from 316 to 431: score -52.1, E = 40 *->ekefeaeiniiPliDImLvlLafvlitAsnfirqgkieVnRLPtAkt + ++ +i Pl ++ ++ + + + + g ++V+ + NP_036459. 316 RLDVNQ-ADIAPL-------MTSLIGVPFPLNSVGILPVD---YLNN 351 geavqsdelkavvvtiteegklyv...ddkpvslEdLqallknylqqnpd + ++ + +++++ +++v+ +++k+v+l L++ +k +l+++++ NP_036459. 352 TDLFKAES--MFTNAVQILEQFKVkmtQKKEVTLPFLFTPFK-LLSDSKQ 398 tlvvlkADenakfetvVkvmDlLkengiknvalatekk<-* + kA + k+ ++ +v++l ke ++ ++ k+ NP_036459. 399 FNILRKARSYIKHRKFDEVVSLCKE-----LIHLALKG 431 Sulfatase: domain 1 of 1, from 44 to 439: score -150.4, E = 5.8 *->PNvllilaDDlGigdlgcyghptirTPnldrLAeeGlrFtnhytatp +l +aD l+ y+ L e+G NP_036459. 44 RRLVLFVADGLR--ADALYE-----------LDENG----------- 66 lCsPSRAaLlTGryphrhGmvsngrlgvlgftaksgglpldettLpelLk SRA + + ++ + + +++g + + + t + NP_036459. 67 ---NSRAPFIR-------NIIM--------HEGSWGISHTRVPT----ES 94 eaGYaTglvGKWHlglnensd.aagdgehlPlgwrGfdyfdgflygspft G + ++G + + s a+g + + fd++++ s +t NP_036459. 95 RPGHVALIAG----FYEDVSAvAKG----WKENPVEFDSLFN---ESKYT 133 ydeencdngegteppeaypeqgwlpqilgyyltdlladkalglldvasaa + + + +++++a a g + NP_036459. 134 W-SWGSPD-----------------------ILPMFAKGASGDHV----- 154 grllakalaasrPFflyisppaphfsilfrnfkevaqpyrapqltqlfvd + ++++ +e + a l+ + +d NP_036459. 155 ----------------------YTY--SYDAKREDFGAQDATKLDTWVFD 180 eaadfiernk.ekPfflylaflrlhvhtplfspaedleskdflgrsqrgr +df+ ++++ f + v + + +d++g+++r NP_036459. 181 NVKDFFHHARnNQSLFSKINEEK-IVFFLHLL------GIDTNGHAHRPS 223 ...YgdlveemDdlvGrvldaLedl.GlldNTlvifTSDnGahlegtpew +++Y ++ +Dd+v ++ G + T ifTSD+G NP_036459. 224 srdYKHNIKKVDDGVKEIVSMFNHFyGNDGKTTFIFTSDHG--------- 264 ygggngplkggKgygslyeGgiRvPllvrwPggiapagrvkeksel.... + g ++ g + + Pl+ ++ gi+ ++rv+ + ++++ NP_036459. 265 -MTDWGSHGAGHPSE------TLTPLVTWGA-GIKYPQRVSAQ-QFddaf 305 .............vshvDlaPTildlAGaplPkvanGakdrplDGvsllp ++ + ++ ++ +v D+aP + +l G+p P +++ G + NP_036459. 306 lkewrlenwkrldVNQADIAPLMTSLIGVPFPL------NSV--GILPVD 347 lllggaapsrrahetlfhyngkgrklravrwprksgktpklkahfftpaf +l+++ + +e +f++ ++ + + + ++k+ + + ++ftp + NP_036459. 348 YLNNTDL-FK--AESMFTN---AVQILEQFKVKMTQKKEVTLPFLFTPFK 391 ...........dddtnngwecvgtvsqaddiedcrcegvetvthhdppel +++++ + + ++++ ++++ +e+ + ++ h+++ l NP_036459. 392 llsdskqfnilRKARSYI--KHRKF-----DEVVSLCK--ELIHLALKGL 432 yDlsrDP<-* +++++ NP_036459. 433 SYYHTYD 439 Sterol_desat: domain 1 of 1, from 318 to 477: score -90.2, E = 11 *->mvnnlletfllfwafyllllilylirclpyfitdfipYsskskiqlk vn + ++ l++ l+ +++ l + + + +Y + +++ NP_036459. 318 DVNQADIAPLMTS---LIGVPFPLNS----VGILPVDYLNNTDLFKA 357 kkkpsklknqqwlefkvvlknifwvsll.iintflleargwgmrklpddl ++++ +q +++fkv++ v+l+ ++++f l + ++ ++l+ ++ NP_036459. 358 -ESMFTNAVQILEQFKVKMTQKKEVTLPfLFTPFKLLSDSKQFNILRKAR 406 pl...PgwfellvqlalfllfgpeDtliYwaHRlLHhpkkrLYkyiHkvH + ++ + +e ++ ++ ++++ NP_036459. 407 SYikhRKFDEVVSLCKELIHL----------------------------- 427 HeyivPtpftaeyaHPlEglllglplviPiviapvifplHvitlliwitl + +++ y H + ++lg+ +vi+ + +wi++ NP_036459. 428 ----ALKGLS--YYHTYDRFFLGVN----VVIG----------FVGWISY 457 adiwtvmiHsGiydfPlslfhliPpLkffyyGAeyHdlHHlqFGikngN< a + + +Hs+ l + G++++ NP_036459. 458 ASLLIIKSHSN-------LIK----------------------GVSKEV 477 -* NP_036459. - - BRO1: domain 1 of 1, from 369 to 498: score -87.3, E = 1e+02 *->efLsipLKkTsevDlvkpLtkyIsntYgsskcerpssyaedalqeLs e + +++ + +ev+l +t ++ + ++ ++ + L NP_036459. 369 EQFKVKMTQKKEVTLPFLFTPFKLLS-----------DS-KQFNILR 403 kLRnqaisvgrpldkseagrldvl......lrYYqqLcaLenkFpssedq k+R+ + ++r +d +++ +++ + ++l+YY + + +F+ + + NP_036459. 404 KARSYI--KHRKFDEVVSLCKELIhlalkgLSYYHT----YDRFFL-GVN 446 HigveFtWyDafdkgslFgssvklsqssLaFEKAcVLFNigalySqiAas +++ F+ + s+ sL + K+ +S++ NP_036459. 447 -VVIGFV--------------GWISYASLLIIKS---------HSNLIKG 472 qinrttddglKqAckyFQqAAGaFahlrdnf<-* + + + K ++++ +++ a l +f NP_036459. 473 V-S----KEVKKPSHLLPCSFVAIGILVAFF 498 DsbB: domain 1 of 1, from 411 to 540: score -56.9, E = 48 *->flnrksflyllwllsaflsligtLtslyfsYIlklkPCvLCwYqRia ++ ++++ +l + + l++ s+y Y R++ NP_036459. 411 HR-KFDEVVSLCKEL--IHLALKGLSYYHT------------YDRFF 442 lfpLvvIllIallqgdlnklralallyvLpsaliGliisiyHyllQlgpG l vvI+ ++ + + l+++ + +++G+ + + + p NP_036459. 443 LGVNVVIGFVGWISYAS-----LLIIKSHSNLIKGV------SKEVKKP- 480 FsplaiCgsmvrFPelLpfqkwvpalfaplgscaekawkfggitmpqlsl s l +C+++ + +a+f + c g + +p + + NP_036459. 481 -SHLLPCSFVA--------IGILVAFFLLIQACPWTYYVYGLLPLPIWYA 521 va..FililivlvLllisk<-* v+++F +i ++v++l ++ NP_036459. 522 VLreFQVIQDLVVSVLTYP 540 oxidored_q3: domain 1 of 1, from 436 to 587: score -88.0, E = 14 *->mtyivliLsillvlGflgVaskpsPiYgaLgLiva.ggvGCGl.... +ty ++L++ +v+Gf+g +s Y+ L+ i +++ ++ G++++ NP_036459. 436 HTYDRFFLGVNVVIGFVGWIS-----YASLLIIKShSNLIKGVskev 477 ...vlslGgsFvalvlFLIYLGGMlVVFgYtvalateeyPEaWgsnkvvw +++ +l sFva+ G+lV F + l+ P +++ NP_036459. 478 kkpSHLLPCSFVAI--------GILVAF-F---LLIQACP------WTY- 508 tigdgvalvlgllievlLvglvlgwtevvivvaltglGdwviYdvegsgl ++++l+ + + ++L + + + vv v++ + l v+ + NP_036459. 509 ---YVYGLLPLPIWYAVLREFQVIQDLVVSVLTYP-LSHF----VGYLLA 550 ir.edlsGvaaLYscgvwmfevaGwvLLval.fvvieltR<-* + + ++v+ +++++ + aG++ + a +f +tR NP_036459. 551 FTlGIEVLVLSFFYRYMLT---AGLTAFAAWpFLTRLWTR 587 Rhabd_glycop: domain 1 of 1, from 625 to 648: score -1.8, E = 73 *->llsliiillltdsqlgkRiPivfpss<-* ll+l+++l++++s+ + + f+ + NP_036459. 625 LLVLLLSLCVVTSLMKR--KDSFIKE 648 ART: domain 1 of 1, from 621 to 651: score -0.8, E = 77 *->mpalhfvLllSVglllstqalssaiqqkdglvkelvL<-* m a++ vLll s+ + s+ +kd ++ke+ L NP_036459. 621 MGAGLLVLLL------SLCVVTSLMKRKDSFIKEELL 651 UbiA: domain 1 of 1, from 445 to 664: score -104.4, E = 30 *->tllvlapvlaglalaaggvntgladllllllallgfflaraagnviN + v+++v + ++++ + + l+ ++ NP_036459. 445 VNVVIGFVGWISYASLL-----IIKSHSNLIKGVS------------ 474 DyfDrdiDaineRrisTpnRPlpsGrispkealtfallllalglalalll + ++ +p+ lp f+++ + +++l+ + NP_036459. 475 --------KEVK----KPSHLLPC---------SFVAIGILVAFFLLIQA 503 nnlafllallglalavlYslpYtrllKRytplgtvvlgaa.galpplmGw ++++ ++ +l + +++ +++ + ++ +v++++++ l + G+ NP_036459. 504 CPWTYYVYGLLPLPIWY-AVL-----REFQVIQDLVVSVLtYPLSHFVGY 547 vAvtgqltpslsvvailLfaalflwtaphdiayaleDvedDrkaGvkslp +++ + v l f+ +++ta+ + a++ l+ NP_036459. 548 LLAFT----LGIEVLVLSFFYRYMLTAGLTAFAAWP-----------FLT 582 vrlGvekakkiallllavavalllllgllgglgllgilylivvlllgaal + k +++ ++++ +++a+++l ++g + i +l+ ga+l NP_036459. 583 RLWTRAKMTSLSWTFFSLLLAVFPLMPVVGR------KPDI-SLVMGAGL 625 lvlaiklvrremdpekiekarlllTfvaslilllvlfaalllaf<-* lvl ++l + + + +++k + + + l++ l+ + +l++ NP_036459. 626 LVLLLSLCV--VTSLMKRKDS--F-IKEELLVHLLQVLSTVLSM 664 Abi: domain 1 of 1, from 564 to 664: score -32.2, E = 20 *->llilllvllaplaEElfFRGilltalerrlkkrytlfgpllaiiiss ++ l++ l+++a +++l+r+ + + +s NP_036459. 564 YRYMLTAGLTAFA--------AWPFLTRL-------WTRAKMTSLSW 595 liFallHlanalellqll.g.........nvliqpvlinwlqllytfllG +F+ll + + l + +++++ + + +++ l++++ l NP_036459. 596 TFFSLLLAVFP-----LMpVvgrkpdislVMGAG-------LLVLLLSLC 633 lvlgllylrrtgsLlapilvHalnNligfill<-* +v++l+ + + + lvH l +l ++ + NP_036459. 634 VVTSLMKR-KDSFIKEELLVHLLQVLSTVLSM 664 DUF216: domain 1 of 1, from 544 to 687: score -70.4, E = 78 *->qVFhlLlfLLAiqRFllYFfPsqRQtEksVkivQkfiqkriwylYlv V +lL f L i+ l Ff ++ ++ + ++ l NP_036459. 544 FVGYLLAFTLGIEVLVLSFFYR-----YMLTAGLTAFAAWPFLTRLW 585 FiiKdvisllviviliayrvlaFfllaslnnskkiefwltgfelleliyv + K + + +Ff l++ ++ ++ + ++ NP_036459. 586 TRAKMTS-----------LSWTFFSLLLAVFPLMPV-------VGRKPDI 617 tvfivlnlLiflsaflYiPiiisirkdflshltSaqqhlllfnkpqkYil + + lL++l ++ +++ ++ ++ ++ ++ NP_036459. 618 SLVMGAGLLVLLLSLCVVTSLMKRKD-----SFIKEE------------- 649 WQtilVfifKlitspvgiififfyldsaafiiliIpitdmpSrkrivvtD +lV+ ++ + ++ ++ ++s+ ++l + NP_036459. 650 ---LLVHLLQVLS----TVLSMYVVYSTQSSLLRKQ-------------- 678 ivttPliIQiS<-* ++Pl+ Qi+ NP_036459. 679 --GLPLMNQII 687 UPF0063: domain 1 of 1, from 209 to 702: score -403.0, E = 88 *->clasRWTDTFkkCslkelkikseQEQlkDnayAvqqsGWllkvlDsf l+ DT + + ++ k n+ +v+ NP_036459. 209 HLLG--IDTNGHAHRPSSRD------YKHNIKKVDD----------- 236 gklpspgllevpyffdGsYqeCkrlsGkgrdrskYetnYCylvlvpgkns g ++ + + f G++++ + + ++ t ++++ + NP_036459. 237 GVKE---IVSMFNHFYGNDGKTTFIFTSD----HGMTDWGSHGAGHPSET 279 ssEHPCsegysgdkaftplpfrfaVCmP..ssCseedlvklfnqlsatlf ++ ++ + P++ s ++ d + l +++ + NP_036459. 280 --------------LTPLVTWGAGIKYPqrVSAQQFDDAFLKEWRLE--- 312 f.mpftacaafCssGTDypveKksaFWgFsaFlivmisivGTLTEKmNRD + + + + +a + + ++F+++ ++i NP_036459. 313 NwKRLDVNQADIAP---L-----MTSLIGVPFPLNSVGIL---------- 344 GLiKKSNTKmRRmilatsvDylrdseynissesekreskgfDlkveeedk vDy n++ +++ NP_036459. 345 -----------------PVDY----LNNTDLFKAE--------------- 358 esllnklVdryfipslalllriLlsFSlSNSlwtNaelilsVkeSLTYLF S tNa +il + NP_036459. 359 --------------------------S----MFTNAVQILEQFK------ 372 RqkpgfIksLdCIRflSmlWVvsGHtfnFllpytidtlvsvfdftksvsf k ++ k + t+ Fl+ + l+s+++ + + NP_036459. 373 -VKMTQKKEV---------------TLPFLFTP--FKLLSDSKQFN---I 401 wnhlllNaflSVDTFFlLSGivvsYlfFKnklkrtSEEsstlkSPltWIl ++ + + K + + +E +l + l ++ NP_036459. 402 LRK--------------------ARSYIKHRKF---DEVVSLCKELIHLA 428 F....YvHRylRLtPAymifiGFftvygkYIqGPf..sasmwnstvtsev +++ +Y H y R+ + iGF++ + Y++ + +s+s+ +++v+ NP_036459. 429 LkglsYYHTYDRFFLGVNVVIGFVGWI-SYASLLIikSHSNLIKGVS--- 474 etCestWWkNllYINNfvdsqketCYpitWYLAvDtQLYLvaPIvLlaLA + ++ L + va+ +L+a+ NP_036459. 475 -----------------KEV-----KKPSHLLPCSF----VAIGILVAF- 497 yfsfvlGtilaivglcigsiftvyilysiydlPAdffgngsstrnnenYq ++l+ + P +++ g + + NP_036459. 498 -------FLLIQAC------------------PWTYYVYGLLPLPIWYAV 522 LekfekvelffdilYekPwiRcpPYliGlLlGYiLAtygkrLRkir.lnw L f ++++ +++ P++ ++GY+LA ++ ++ l++ NP_036459. 523 LREFQVIQDLVVSVLTYPLSH--------FVGYLLAFTLGI--EVLvLSF 562 vlsvigwliavglavaclfatydYdkgafWssvqtrLYRYqVFKiiiqNK + + + + +++a ++++ W+ NP_036459. 563 FYRYMLTAGLTAFAAWPFL-------TRLWTR------------------ 587 KNiFiNYKYFLFFFiFFAfefskatYynfsRaIsnrllWsiavawvI... + + ++ fs ll + ++ v++++ NP_036459. 588 ------------------AKMTSLSWTFFSL-----LLAVFPLMPVVgrk 614 ..vlnhmGwGYLqfGPLInaFmshpiWqPLg..rLSfcA..YiVHwmvLy ++++ mG+G L+ ++s+ + + L ++++Sf+ ++++VH ++ NP_036459. 615 pdISLVMGAG------LLVLLLSLCVVTSLMkrKDSFIKeeLLVHLLQVL 658 yflnigdkPlhfystwqvFmyyaipat..iLSYifAfFwsclfEiPlPtl ++ + +++++++ p+ ++i+S A s+l+ + P l NP_036459. 659 STVLSMYVV--YSTQSSLLRKQGLPLMnqIISW--ATLASSLV-V--PLL 701 k<-* NP_036459. 702 S 702 BPD_transp_2: domain 1 of 1, from 424 to 707: score -122.5, E = 5.9 *->lsqlilnglvlgglyailAlgltlvyGvagipnfahGefyllgayla l l+l gl++ +y +lg++ v+G+ g ++ a+ + l+ NP_036459. 424 LIHLALKGLSYYHTYDRFFLGVNVVIGFVGWISYASLLIIKSHSNLI 470 yvllslgl..slglailylGlvalltaafvglgayvaalllkplrlrgll ++ +++ ++s+ l+ + va+++ ++++l++ a +++++ ++l NP_036459. 471 KGVSKEVKkpSHLLPCS---FVAIGILVAFFLLIQ--ACPWTYYVYGLLP 515 llsv.Avi.tvGvvaaiatliigiilllllgkyleiltgirglsispfvf l+ + Av + v+ ++ +++ +l ++g++l+ ++gi+ l+ s f NP_036459. 516 LPIWyAVLrEFQVIQDLVVSVLTYPLSHFVGYLLAFTLGIEVLVLSFFYR 565 ialefggieiggsyllsvpdaglelsrtvreggWdrfslifgaflspyyr ++l+ g+ + + +l++ NP_036459. 566 YMLTAGLTAFAAWPFLTR-------------------------------- 583 kvilylviLlllaLvlilyrrLlnskfGralrAvredeelAralGinvek +++ + +++L++ ++ l Av + ++ ++G ++ NP_036459. 584 ----LWTRAKMTSLSWTFFS---------LLLAVF--PLMP-VVGRKPD- 616 iklltFaiSsalAGlAGaLyalytGvisPeigdfav.lilkafaivvLGG ++ +++ AG L+ l ++ + + + ++i + +++ +L NP_036459. 617 ---ISLVMG------AGLLVLLLSLCVVTSLMKRKDsFIKEELLVHLL-- 655 lGniyGavlGtlglviglsleviltlyiaylfggplaLivvtvlfnFFgi + +vl+ +v++ ++++++l + g NP_036459. 656 --QVLSTVLS--MYVVY-------STQSSLLRKQ--------------GL 680 vllkdvvflllliavLilkPqGlfgkke<-* l+ +++++++l+ L++ P ++ ++ NP_036459. 681 PLMNQIISWATLASSLVV-PLLSSPVLF 707 ion_trans: domain 1 of 1, from 542 to 710: score -22.3, E = 44 *->ilfildllfvllflleivlkfiayglkstsniaakylksifnildll f+ ll+++l + ++vl f+ ++y+++ + + NP_036459. 542 SHFVGYLLAFTLGIEVLVLSFF-----------YRYMLTAGL--TAF 575 ailplllllvlflsgteqvakkrlrerfslelsq.wyyrilrflrlLrll a++p+ l+ ++ ++++ ++ NP_036459. 576 AAWPF-LTRLWTRAKM-----------------TsL-------------- 593 RlLrllrllrrletlfefelgtlaWslqslgralksilrfllllllllig + ++++l +++l + ++ +++i ++ + ll+l++ NP_036459. 594 ----SWTFFSLLLA-----VFPL----MPVVGRKPDISLVMGAGLLVLLL 630 fsvigyllfkgyedlsenevdgnsefssyf..dafyflfvtlttvGfGdl + l k+ +s+++++ + l++ l+tv + NP_036459. 631 SLCVVTSLMKR--------------KDSFIkeELLVHLLQVLSTVLSMYV 666 vpv................wlgiiffvlffiivgllllnlliavi<-* v +++++ ++++ + +++++ +++ + ++v ll +l+ + NP_036459. 667 VYStqssllrkqglplmnqIISWATL-ASSLVVPLLSSPVLFQRL 710 BioY: domain 1 of 1, from 578 to 714: score -71.8, E = 48 *->isiledflpikPVPlTlQtfgVlLaGllLGPklgaLsqLiYlllGal ++ +L+ l ++k+ Ls + ll + NP_036459. 578 WP--------------------FLTRLWTRAKMTSLSWTFFSLLL-A 603 GlPvFAgfsGGiavflGPTgGYLlGFilAafla.GwlaerhRLCtPwRkr +P+ + + ++ l +G Ll +l+ + +++ +++ + NP_036459. 604 VFPLMPVVGRKPDISLVMGAG-LLVLLLSLCVVtSLMKRKD-------SF 645 gRketlmllLaticLvGlgvIYllGivvLalflgldekvlssdavgafml ++ e+l+ lL + L +++Y + + l + + l+ + +++ NP_036459. 646 IKEELLVHLLQV--LSTVLSMYVV-YSTQSSLLRKQG--LP--LMNQIIS 688 gvilPtmviFAAtvLiFligdfvvkalvavllarritpal<-* ++ l + vv l ++ l+ r+ +l NP_036459. 689 WATLA--------------SSLVVPLLSSPVLFQRLFSIL 714 MgtE: domain 1 of 1, from 617 to 725: score -64.4, E = 55 *->fiPlLiGlgGNvGtqlssrlsrgLalGevsskkrvlrvlakelltsi i l++G g +l+ +L l v s+ ++ + + ke l + NP_036459. 617 -ISLVMGAG---------LLVLLLSLCVVTSLMKRKDSFIKEELLVH 653 llgvvlslallfvagilgggsgvideegeallflivaislliislvalll ll v++ ++++ v++ ++ + + g +l+ +i++ +l++slv+ ll NP_036459. 654 LLQVLSTVLSMYVVYSTQSSL--LRKQGLPLMNQIISWATLASSLVVPLL 701 gvlipilfkklglDPdnvsgPlITTlaDittlllIyllia<-* + +p+lf +l ++ +++l + yll+ NP_036459. 702 S--SPVLFQRL--------------FSILLSLMSTYLLLS 725 oxidored_q5_N: domain 1 of 1, from 650 to 725: score -63.8, E = 22 *->MLKiIlPTiMLlPtTwlskknwlWintttySlLIsliSLtlLnnhse +l ++ ++ T ls + + t+S L+ L l+n+ NP_036459. 650 ----LLVHLLQVLSTVLS----MYVVYSTQSSLLRKQGLPLMNQ--I 686 ngwnnlslylssDplStPLLvLScWLLPLMlmASQnHLskePlnrqRlfI +w +l + +l PLL + P + qRlf NP_036459. 687 ISWATLAS-----SLVVPLL-------------------SSPVLFQRLFS 712 slLiiLQtlLImt<-* +lL + t L ++ NP_036459. 713 ILLSLMSTYLLLS 725 DUF6: domain 1 of 1, from 573 to 725: score -16.5, E = 3 *->fiWalytvfskklle...spltftawrfliagilllilllflkkgpp ++a++ ++++++++ + ++l+ t++ +l+a ++l+++ ++p NP_036459. 573 TAFAAWPFLTRLWTRakmTSLSWTFFSLLLAV---FPLMPVVGRKPD 616 l...........................lallslk.ilallylgilgtal ++ + + + ++ ++++++++ l l +++ +l++ + NP_036459. 617 IslvmgagllvlllslcvvtslmkrkdsFIKEELLvHLLQVLSTVLSMYV 666 gyllyfyalkyvsaskasvlss.lsPvftlilsvllLgEkltlkqllGiv y+ + +l++ + ++s + + +l+ lL ++ + l++i+ NP_036459. 667 VYSTQSSLLRKQGLPLMNQIISwATLASSLVVP--LLSSPVLFQRLFSIL 714 lillGvllisl<-* l+l +++l++ NP_036459. 715 LSLMSTYLLLS 725 ABC2_membrane: domain 1 of 1, from 519 to 729: score -146.9, E = 39 *->lrslfryreLilqLlkrdiKtRYrgSaLGylWsfLnPLlmilvytfv ++ ++r + +i L+++ + PL + + y++ NP_036459. 519 WYAVLREFQVIQDLVVS---------------VLTYPLSHFVGYLLA 550 FsfllrsrlpgddrlnyivylltGllpwqfFsealsrgtssvvanasLik F + l++ +f++++l++g++++ a NP_036459. 551 FTLGIEV-----------------LVLSFFYRYMLTAGLTAFAA------ 577 KlnfPreilplsavlselvvnflisliillivlilfgenp.fswnvlllp +f + +++ s +f+ l+ ++++ + g+ p++s+ + + NP_036459. 578 -WPFLTRLWTRAKMTSLS-WTFFSLLLAVFPLMPVVGRKPdISLVMGAGL 625 llllllvlfslGl.....glilsalgvffRDigqilglllqllfflsPif l+lll + +++l ++++++i + + + ++l++l ++l + NP_036459. 626 LVLLLSLCVVTSLmkrkdSFI------KEELLVHLLQVLSTVL-----SM 664 YplstiPeqyrsillelNPlvhiiesyRdillgGawvpsdlesllylllv Y + ++++ l + +++ ++ l + ++ + l ++l+ NP_036459. 665 YVVYSTQSSLLRKQG----LPLMNQIISWATLASS-LV--VPLLSSPVLF 707 s..lillliGlliFrkfekrfa<-* + + +ll+ ++ + ++ + + NP_036459. 708 QrlFSILLSLMSTYLLLSTGYE 729 UPF0056: domain 1 of 1, from 555 to 732: score -138.2, E = 78 *->lkfiisafvsLfaiiNPiGnvPvFisLtenypaeerkrIilrAsiia + +++++f+ + ++ +++ + Lt+ + ++ ++++ + NP_036459. 555 IEVLVLSFFYRYMLTAGLTAFAAWPFLTRLWTRAKMTSLSWT----- 596 fliLllFlvfGklIlklFGIsid.AfriAGGILLFlIaldMlfgkqskvD f+ Lll+++ ++ G d ++ ++ G+L+ l +l + ++ NP_036459. 597 FFSLLLAVF---PLMPVVGRKPDiSLVMGAGLLVLLLSLCVVTSLMKR-- 641 PektsksEkeeseeideIavvPLAiPLiAGPGaITtvmvlmseasssTFA +++ kee+++ ++ + +++ +v++++ s NP_036459. 642 ---KDSFIKEELLVHLLQVLS----------TVLSMYVVYSTQSSL---- 674 DigeklavvlAilLawlitflil...lsssfiiRlLGrtGinaltRimGL + ++++ ++w++++ +l +l+ss+++ + R++ + NP_036459. 675 -LRKQGLPLMNQIISWATLASSLvvpLLSSPVL----------FQRLFSI 713 lLvaiavQmiv.dGikgif<-* lL ++++ + +++G +f NP_036459. 714 LLSLMSTYLLLsTGYEALF 732 DUF56: domain 1 of 1, from 611 to 739: score -57.7, E = 12 *->mlillllalvfaiillflliRfnvlppfsklyerviellcRekeknr ++ ++ ++lv +++ll+ll+ + v+ +l+++k+ NP_036459. 611 VGRKPDISLVMGAGLLVLLLSLC-----------VVTSLMKRKDSF- 645 dhglgaiifyilglvfvsllFpmevAiasilvLalGDglAaiIGrryGrr + ++ +l ++ s++++m v+ + + +++ r+ G NP_036459. 646 --IKEELLVHLLQVL--STVLSMYVVYS---------TQSSLL-RKQGL- 680 tpilgngKSlEGslAfFvasflillvfygyygGYYvnPaaiallSrlsav p + + S++ ++ +v+ +l++ v+ ++ NP_036459. 681 -PLMNQIISWATLASSLVVPLLSSPVLFQRLF-----------------S 712 llalvlgliaalvEalelksRldDNLsiPllsAil<-* +l+++ ++ l+ ++e Pl+ ++l NP_036459. 713 ILLSLMSTYLLLSTGYEALF--------PLVLSCL 739 Herpes_glycop: domain 1 of 1, from 433 to 749: score -286.7, E = 87 *->mksskvDtfnwRtWlvqvvcfvlmfvnsvvtLIaAsfPglGFPCyYa + D+f + v vv ++ + + +LI s +l NP_036459. 433 SYYHTYDRFFL---GVNVVIGFVGWISYASLLIIKSHSNL------- 469 alVDYsalNlTvrNGvWvrrrag...hlTPtLFLEtpelfaYvvfTalvl +++ v ++ ++++hl P ++v++ lv NP_036459. 470 -----------IKG---VSKEVKkpsHLLP---------CSFVAIGILVA 496 lavav......Yyivg......AVairrakkkfeftaslnqlsawItlvG ++ +++ + +Yy+ g + + + a+ r ++ + +l + + NP_036459. 497 FFLLIqacpwtYYVYGllplpiWYAVLR---E---FQVIQDLVVS--VLT 538 dpttLflgiLrmWTlQlfvllLSyKhvvLAAFvYllHFacsvaFtvsfiT p++ f+g L + Tl + vl+LS+ F ++ T NP_036459. 539 YPLSHFVGYLLAFTLGIEVLVLSF-------------------FYRYMLT 569 rGyssawyskfveqlippnplLhrvvgpgRaVvvNlylllLaLetlvfsL + ++++ p ++L+ +Ra ++ l L +vf+L NP_036459. 570 A-----G--LTAFAAWPFLTRLW-----TRAKMTSLSWTFFSLLLAVFPL 607 s........lmlalGNSFyisvsdtVfgAvnlFliLavvwlivtElvLsk ++ ++++++ l+ G+++ +++ + ++ ++ +++ E L++ NP_036459. 608 MpvvgrkpdISLVMGAGLLVLL----LSLCVVTSLMKRKDSFIKEELLVH 653 YvkvlfGpylGtLvfvgslglalPvyr.R.YeaifvsatQaPnlhtgvri ++vl + v++ ++ + + R+ ++ + ++ + NP_036459. 654 LLQVLST------VLSMYVVYSTQSSLlRkQGLPLMNQ----IISWATLA 693 nlAviailclamivvRlvRaylyhrkkhtkffvrmpksrYkalvskarvR v+++l+ + Rl+ ++l + t++ + ++ Y+ NP_036459. 694 SSLVVPLLSSPVLFQRLFSILLSLMS--TYLLL---STGYE--------- 729 ssmrSrrRpsplspkvrarrrnepslnqaprasylreees<-* + +p + + ++ e + NP_036459. 730 --------------------ALFPLVLSCLMFVWINIEQE 749 Cation_ATPase_C: domain 1 of 1, from 613 to 751: score -58.2, E = 69 *->rkPPrpkkepLitrgliffrYlviGvyvgaatvGAaaffvvmy.edG rkP + +++ +G+ v ++ + ++ + +m ++d NP_036459. 613 RKPDI-------S---LVMG---AGLLVLLLSL--CVVTSLMKrKDS 644 fpplslyqlrnawdcdgfndltdsyGqeltasrdmtmaftafTvfFsvLV + + l + + q+l+ m+ v++ NP_036459. 645 ---------------FIKEELLVHLLQVLST--VLSMY-----VVY---- 668 viqmfNAlncrsernSlf...qmgpfswNkwLllAvvlslalhfliiYvP s Sl++++ + + N+++ +A +s +++ l+ NP_036459. 669 -----------STQSSLLrkqGLP-LM-NQIISWATLASSLVVPLLSSPV 705 plqtiFg.ttpLs........wqeWllvigfsfpvfildEirKfiiRrrp +q+ F+ +L ++ ++++e l+++++s + f++ i NP_036459. 706 LFQRLFSiLLSLMstylllstGYEALFPLVLSCLMFVWINI--------- 746 dgWlereky<-* e+e++ NP_036459. 747 ----EQETL 751 LacY_symp: domain 1 of 1, from 480 to 761: score -362.3, E = 85 *->lipfkNtnFwrFglFFFFYFFISMsayFPFfPiWLkeVngLtKTetG + + F g F+ I + + + V gL + NP_036459. 480 PSHLLPCSFVAIGILVAFFLLI-QACPWTYY------VYGLL--PLP 517 IvFScisLFsIlFqPlfGlisDKLGLkKhLiWcIsllLVlFAPFFIYVFe I ++++ Fq +i+D ++s Vl+ P +V + NP_036459. 518 IWYAVLR----EFQ----VIQDL---------VVS---VLTYPLSHFV-G 546 PLLQlNIlaGalvGGvflGlvysAGaGaiEA..YIEkvSRnshFEYGkAR LL + lv f AG a A ++ + + +A NP_036459. 547 YLLAFTLGIEVLVLSFFYRYMLTAGLTAFAAwpFLTRL-------WTRAK 589 mfGCvGWALCAsiAGIlFsIdPhivFWlgSGfAliLllLLllsKpdkshs m ++ W +F S+ +++ l+ + + k+ NP_036459. 590 MT-SLSWT--------FF-----------SLLLAVFPLMPVVGR--KPDI 617 AiVaDAlGAnksaFSlrlaieL......FkmrkfWvFvlYvV.GVasvYD V+ A G + Sl ++ +L +++++F + v l v + V s Y NP_036459. 618 SLVMGA-GLLVLLLSLCVVTSLmkrkdsFIKEELLVHLLQVLsTVLSMYV 666 VFDQQLFAvFFagFFespqvGTrvFGyvTTfGelLnAlIMFcaPfIvNRI V Q ++ +G l n +I NP_036459. 667 VYSTQ------SSLLR--KQGLP----------LMNQII----------- 687 GaKNALLiAGvIMsvRIlGsafattaleVvILKlLHafEvPFLlVGvFKY + at a v vP+ NP_036459. 688 --------------------SWATLASSLV---------VPL-------- 700 itsnFdkRLSATifLIGFqfskqLaivlLStlaGkLYDhvGFQtaY.lvL LS+ + ++ L ++lLS L + G+ ++lvL NP_036459. 701 --------LSSPV------LFQRLFSILLSLMSTYLLLSTGYEALFpLVL 736 GiIvlsftlISiFTLSgsreqivlptpe<-* ++ I TL s+ v NP_036459. 737 SCLMFVWINIEQETLQQSG---VCCKQK 761 Worm_family_8: domain 1 of 1, from 537 to 778: score -305.4, E = 61 *->MTisYnldVstssiwtFfkLllRWKGSiWKavwkELivWlflY.... T++ + +++ l++++ + NP_036459. 537 LTYPLS----------------------------HFVGYLLAFtlgi 555 ..yiIFsaIYRfaLsksqwdgyqeiFekl..vryfdsrldytIPLtFMLG + +++ s++YR++L+++ + F ++ + + +r ++ L + + NP_036459. 556 evLVL-SFFYRYMLTAGL-----TAFAAWpfLTRLWTRAKM-TSLSW--T 596 FFVttVvrRWwkiFdniGwIDniAlavaayir..GkdeeaRiiRRnIiRY FF + +lav +++ G+ + NP_036459. 597 FF-------------------SLLLAVFPLMPvvGR--K----------- 614 lVLsQvLvFRDISmkVRkRFPTldtlVaAGlMteeEldklsesikskysv P++ + AGl+ l + + + NP_036459. 615 --------------------PDISLVMGAGLLV------L-LLSLCVVT- 636 gqkYWvPInWafsLlQyearkeGlIdsdylynvlwdeIkeFRtglalLsn sL+ +rk+ I+ l++ l++++ ++Ls+ NP_036459. 637 ------------SLM---KRKDSFIKE-ELLVHLLQVLS------TVLSM 664 yDWVPIPLvYPQVVfLAVRlYFlvCLfgRQfl........dsddndnkte y vY Q+ ++++ ++++ + + NP_036459. 665 Y------VVYST-----------------QSSllrkqglpLMNQII--SW 689 ..nyIDlyfPVPFimTi...lQFIFyvGWmKVAEvLLNPlGEDDDDFEcN + +l++P +++++ +Q +F +LL NP_036459. 690 atLASSLVVP---LLSSpvlFQRLF--------SILL----S-------- 716 yiIDRNLavGlaIVDtlWvkEnqydrtPdlek..DaFwdedaePlystse L+ + +t+ y+ + +l + +F ++ + e NP_036459. 717 ------LMSTYLLLSTG------YEALFPLVLscLMFV---WINIEQ--E 749 sFakipnnplvGSaanvkleeddveEvkmvph<-* + + + + ++++ + ++ + +++++ NP_036459. 750 T-LQQSGVCCKQKLTSIQFSYN--TDITQFRQ 778 CAT: domain 1 of 1, from 769 to 786: score 0.0, E = 99 *->ydeDFkeFyknYlsDiae<-* y+ D+++F + Yl+Di++ NP_036459. 769 YNTDITQFRQLYLDDIRR 786 ERG4_ERG24: domain 1 of 1, from 436 to 793: score -328.4, E = 46 *->reieyEFGgfaigalgil.....iGlpiLvHvlmlylngcsgffalm + + F g +++g ++ + +l i+ +l+ + ++ ++ NP_036459. 436 HTYDRFFLG-VNVVIGFVgwisyASLLIIKSHSNLIKGVSKEVKKPS 481 fglPksldlaeLmnkikdpsllvfpgPLPAlyelWerylwtVfll..wyv +lP s+ i+ l f + + A W+ y++++ l+ wy+ NP_036459. 482 HLLPCSF------VAIGI--LVAFFLLIQACP--WTYYVYGLLPLpiWYA 521 ....iqavfYllLPGkvveGlpLsHldGrrLkYklNafwsattlll.... +++q++++l + v pLsH G L l ++ l+l+ NP_036459. 522 vlreFQVIQDLV---VSVLTYPLSHFVGYLLAFTL-GIEV---LVLsffy 564 ..tlAiigvlhftqlfeltylyDnFvqlmsaAIifaFaLsiylYvrSLka + l++++++ + + lt l + ++ + f++ L+++ L + NP_036459. 565 ryMLTAGLTAFAAW-PFLTRLWTRAKMTSLSWTFFSLLLAVF----PLMP 609 pefkkdGnGkRekdLapGgnSGnliYDFFiGreLNPRiGLPLikllDlKm ++k + +l+ +G+ G NP_036459. 610 VVGRKP---------DI-----SLV----MGA------G----------- 624 FfElRpGllgWvvInlaallkqyetyGyvtPsLlfvllnSFQlLYvfDgl l+ ++++l + ++ + l+v l+ Q L NP_036459. 625 --------LLVLLLSLCVVTSLMKRKDSFIKEELLVHLL--QVL------ 658 knEeavLTTMDItyDGFGFMLaFGDlvwVPFtYSlQtlYL......svHD vL + +YS+Q L++++ + NP_036459. 659 ---STVLSMY--------------------VVYSTQSSLLrkqglpLMN- 684 PselgWstlyavaIyvlllcGYyIFrtANsQKNnFRkQiyGdkvgRKtnP + ++W t a+++ v ll + F R + NP_036459. 685 -QIISWAT-LASSLVVPLLSSPVLFQ---------R-----------LFS 712 edPkLihKNLKyiqTknGskLLvsGWWgfaRhINYlGDwlqSLsWsLptG + +L +y+ ++G Y + + Ls + NP_036459. 713 ILLSLMS---TYLLLSTG----------------YEALFPLVLSCLMFVW 743 FnGYqiLsAGsnAPGAitmLDGREvvqGEARGWGsvLPYFYilYFavLLv +n E q L+ ++ F NP_036459. 744 IN------------------IEQETLQQSGVCCKQKLT---SIQFSY--- 769 HReaRDehKCkkKYGedWEeYckrVPYrIiPYiy<-* D+ + Y +d + +++ + NP_036459. 770 ---NTDITQFRQLYLDDIRR-------AFFLVFF 793 aa_permeases: domain 1 of 1, from 490 to 807: score -377.9, E = 99 *->LkRgLknRHiqMIAiGGaIG..TGLfVGsGktLhkaGPagllLgYli aIG ++f+ L++a P Y NP_036459. 490 -----------------AIGilVAFFL-----LIQACP----WTYYV 510 iGlmiyfimrs.LGEmvvffPgDmevsGSFstYA.trfigpsaGfatGW. Gl+ ++i ++ L E v+ + +S tY + f+g ++f++G++ NP_036459. 511 YGLLPLPIWYAvLREFQVIQD----LVVSVLTYPlSHFVGYLLAFTLGIe 556 ....nYwfnWvvviplEltaasiii.qyWf...pdnsiplwvwiliFlvv +++ + ++ l++ aa ++ W++ +++ w + + l+v NP_036459. 557 vlvlSFFYRYMLTAGLTAFAAWPFLtRLWTrakMT--SLSWTFFSLLLAV 604 lviiNlfgVK.....gyGNLKEmEFWfasiKViaivgFIIlGfvlilGLv + ++ ++g K++ + + G a + + l+ +++ NP_036459. 605 FPLMPVVGRKpdislVMG---------------AGLLVLLLSLCVVTS-- 637 flggpadGslgaigfryWndspfgGaFphGtdgGrFlgflsvfviaaFsF l +++d + ++++ NP_036459. 638 -LMKRKD------------S-----FIKEE-------------------- 649 aGtELVGiaAgEsknPrKsiPkAikqVvwRIllFYilslfvigllvPwnD + + l +ls+++ + +v + NP_036459. 650 ----------------------------LLVHLLQVLSTVLSMYVVYSTQ 671 pkllasgasakPdasaSPFVivfenaGikvlahimNaVILtavLSagNSg ll+ G++ +i+ NP_036459. 672 SSLLRK-------------------QGLPLMNQII--------------- 687 lYasSRmLysLAqqGyAPkYDifakvdRkGvKVPlna..vlvslvfg.ll +a + + v VPl +++vl+ +f+ ll NP_036459. 688 ---------------------SWATLASSLV-VPLLSspVLFQRLFSiLL 715 avllnsvspaaatVFnwLlnisglsalfvWlvIalshlrFRkAikkqGrs ++++ ++ t ++ L ++ +fvW I +l ++ G+ NP_036459. 716 SLMSTYLLL--STGYEALFPLVLSCLMFVWINIEQETL---QQ---SGVC 757 ldelpfkaplgPygswlglffiiivlviqgytafapmgdSPGKlfdaedf + + ++s+ i q+y + ++ NP_036459. 758 CK--------QKLTSIQFSYNTDITQFRQLYLDDIR-------------R 786 vaaylaiplfiilwigykfikr<-* ++++ ++l+ ++++++++ NP_036459. 787 AFFLV-FFLVTAFFGTGNIASI 807 Steroid_dh: domain 1 of 1, from 693 to 841: score -90.3, E = 42 *->akmPlfniakAfahNHFctlnGflqgrylsyyqpyylyeTiFVsvka a ++++ +++ F l ++l++ + s y + NP_036459. 693 ASSLVVPLLSSPVL--FQRLFSILLS-LMSTYLL---------LSTG 727 ddwytlfrfllGivlfv.....igmliNihsdiiLrsklPQLHVSiD... ++ +++ ++ +++++++ ++++++ + ++ ++L Si + NP_036459. 728 YEALFPLVLSCLMFVWInieqeTLQQSGVCCKQKLT--------SIQfsy 769 ..DiSLTQWAGAVLFWiCNWKQddLRkpGetgykIPrglirNYAYGicFG ++Di + R + ++ r F NP_036459. 770 ntDIT------------------QFRQLYLDDIR--R----------AFF 789 glFeLVScPNYfgEileWiGfALatwslpalaFalFtvanltprAkahHk F LV++ +g i + +f La+ + F+ + + ++ + NP_036459. 790 LVFFLVTAFFGTGNIASINSFDLASV----YCFLTVFSPFMMGA------ 829 WYlKkFkekYPksRkaLIPFvl<-* l + k+LIPFvl NP_036459. 830 --LMMW--------KILIPFVL 841 secY: domain 1 of 1, from 655 to 873: score -261.3, E = 52 *->SiFALGImPYITASIIvQLLtvDviPaLeelqkEgGEaGrrKLnQyT +Q+L++ v+ +++ +++ L + NP_036459. 655 ----------------LQVLST-VLSMYVVYSTQSSLLRKQGLPLMN 684 RYLltlvlAfiQSlgivfiarrgpLlgPgdmlsgnlvinpnfffyllivl ++ + +A + S +v ++ + P l+ + +f++ll NP_036459. 685 QI---ISWATLASSLVVPLLSS-----P------VLF--QRLFSILL--- 715 aLttGsmlvMWlgEqITekGIGNGiSLlIFaGIaaglPsgllkqifeqan +l+ +++ + NP_036459. 716 ---------------------------------------SLM-STYLL-- 723 lgsgdplfagivfllvllivfllvifgvVFVqeavRkIPvqyAKrqlgrr + ++ ++ +v+ +f+ + +++ + ++ ++ NP_036459. 724 --------LSTGYEALFPLVLSCLMFVWINIEQ----------ETLQQSG 755 rvggqstYLPLKvNqAGViPVIFASsilllPatlgqflnsqdgsipafls + ++q t +qf ++d NP_036459. 756 VCCKQK-------------------------LTSIQFSYNTD-------- 772 nvnwvrwianylspnsiNvisilptsilylllYliLIIfF.syFYvsTiq +++ + yl+ ++l++++ fF++ + +s NP_036459. 773 ---ITQFRQLYLD----------DIRRAFFLVFFLVTAFFgTGNIAS--- 806 lNPeeiAeNLKKmGsfIPGiRPGvkaTekYlekvlnRLTfvGSlFLaliA +N +++A v ++++ +++ + +++ ++ NP_036459. 807 INSFDLAS---------------VYCFLTVFSPFMMGALMMWKILIPFVL 841 ilPsi.leallgvglpvffglGGTSLLIvVGVaidTvkQ<-* ++ +++ l+ +l+ SL ++V V+ d + NP_036459. 842 VMCAFeAVQLTT-------QLSSKSLFLIVLVISDIMAL 873 DAGK_prokar: domain 1 of 1, from 789 to 878: score -62.4, E = 73 *->lrPrLikSaeYalkGikeAfktEraFRheavaalaaviaafllgvsa + ++ + + ++G + + + ++++ +++++ + a NP_036459. 789 FL-VFFLVTAFFGTGNIASIN-----SFDLASVYCFLTVFSPFMMGA 829 IewvllilsvlLVM.alElLNtAIEeVVDlisdehhseLaKnAKDmaagA +++ + LVM a+E+ V l++ ++ L NP_036459. 830 LMMWKILIPFVLVMcAFEA--------VQLTTQLSSKSL----------- 860 VLvaiviagIvgliillf<-* L+ +vi+ I +l +++ NP_036459. 861 FLIVLVISDIMALHFFFL 878 xan_ur_permease: domain 1 of 1, from 534 to 879: score -207.7, E = 37 *->gqtlllGLQhllaMfaatvlvPllvgdalclglsaeslaylisttll + l+++L h+ + a l +++++ + +l NP_036459. 534 VSVLTYPLSHFVGYLLAFTLGIEVLVLSF------------FYRYML 568 vsGigTllQllrYgigrifGirlpivlGsSFafvtPaiglialmialGsa ++G+ ++ ++++ ++ ++ ++ + + S +f++ + +++ lm + G NP_036459. 569 TAGLTAFA-AWPFLTRLWT---RAKMTSLSWTFFSLLLAVFPLMPVVGRK 614 padqgplepigialgglfGallvagvlfilisftglrgrLarlfPPvVtG p +i +g+ + ll++ ++++ +++ + + + +V NP_036459. 615 P-------DISLVMGAGLLVLLLSLCVVTSLMKRKDS-FIKEEL--LVHL 654 pvvllIGLsLipiavkgvaggwaaildgllTllvgslellglavvvlavi vl Ls + ++ +++ + +l+ + ++ +s l+ ++vv++++ NP_036459. 655 LQVLSTVLSMYVVYSTQSSLLRKQGLPLM--NQIISWATLASSLVVPLLS 702 lllsvftavlkgffkslpiLiGiivGwilalfmGpsivdlspeGseARtD ++ + ++++iL+ ++ ++l + NP_036459. 703 SPVLFQ--------RLFSILLSLMSTYLLLSTGY--EALFPL-------- 734 kNSLavvrdapwfqlplplpfglpldalgafnpgliltmlavaivaivEs v++ + ++++ ++ ++ ++ + + ++ + NP_036459. 735 -----VLSCLMFVWI----NIEQET-----LQQSGVCCKQKLTSIQFSYN 770 iGditatakvsgrdlkpgtykprlrRglladGlatllaGlfGagtPtTtf + ++++ + + y ++rR+++ + l++++fG+ NP_036459. 771 T-------DITQ--FRQ-LYLDDIRRAFFL--VFFLVTAFFGT------- 801 aeNiGvvalTrvaSrrvgvtaavilillGlfpKfaallssIPspVlGGvm Ni+ + + aS++ ++t+ ++p+++++l + NP_036459. 802 -GNIASINSFDLASVYCFLTV--------FSPFMMGALMM--------WK 834 lvlFgmiagsGvsilqsvdldysaRnllIiavSlvlGlgiptvpei<-* +++ ++++ ++ +q + s+ l++i + + + + + + + NP_036459. 835 ILIPFVLVMCAFEAVQLTTQL-SSKSLFLIVLVISDIMALHFFFLV 879 PTS_EIIC: domain 1 of 1, from 568 to 879: score -179.4, E = 96 *->GkalMlPiaPvLpAaGlLlGlggalsnegivdalnildefiqliaef + a +a + p+ l +++ ++ + l ++f NP_036459. 568 LTAGLTAFA-AWPF------LTRLWTRAKMTS----------LSWTF 597 ikagGgavFdnLPllFAigiAiglakdlpagvAglagfvgylvlnaainv avF ++P++ g d +v g + +v l+l + +++ NP_036459. 598 FSLLL-AVFPLMPVV-------GRKPD-ISLVMGAGLLVLLLSLCVVTSL 638 algaaggtpeasfssavgagsgtakspayaniLGietlqtGvfGGiivGl + + ++ ++ + + + lq+ +++ + NP_036459. 639 M-KRKDSFIKEELLV--------------------HLLQVL---STVLSM 664 Laaylynrfy..eikLP...kvL..gffsgkrfVPiitslitgivtalii ++y ++ +LP ++ ++ + +++ ++VP+++s + NP_036459. 665 YVVYSTQSSLlrKQGLPlmnQIIswATLASSLVVPLLSSPV--------- 705 gpiwppiqdginailtglgllgsaGalgafifGfierlLiPfGLHHilna ++ + ++ +++ +t l l s+G+ + +f + +++L+++ + NP_036459. 706 -LFQRLFSILLSLMSTYL--LLSTGYEA--LFPLVLSCLMFV-----WIN 745 pfwftiaggkni...................................... ++ +t+ + +++ ++ + + +++ ++ ++ ++ ++ NP_036459. 746 IEQETLQQ---Sgvcckqkltsiqfsyntditqfrqlylddirrafflvf 792 .........intiaegnlvgyEvvywGdqniFfaqladptvdftagstad + +++n + ++n F + +++ NP_036459. 793 flvtaffgtGN-------IA-------SINSF--------DLASVY---C 817 flsGkfpmmmfGlPGAALAmyhtakpEnrkkvaglliSaaltafLtGITE fl+ + p+mm++l +m+ + p + ++++ + t ++ NP_036459. 818 FLTVFSPFMMGAL-----MMWKILIP-----FVLVMCAFEAVQLTTQLSS 857 PlEFgflFvapDlLfvihailaG<-* + F++ +v +++h + NP_036459. 858 KSLFLIVLVIS-DIMALHFFFLV 879 cytochrome_b_N: domain 1 of 1, from 861 to 883: score -0.5, E = 68 *->FlLPfillillllHLlfL.HetG<-* Fl+ +++ +++lH++fL + +G NP_036459. 861 FLIVLVISDIMALHFFFLvKDYG 883 UPF0118: domain 1 of 1, from 594 to 886: score -134.4, E = 9.9 *->llliliflllilafipfinvietllvplliAlvlayllnPvvrfLqk ++++ +ll + + p+++++ ++++ + ++l++ l vv+ L k NP_036459. 594 SWTFFSLLLAVFPLMPVVGRKPDISLVMGAGLLVLLLSLCVVTSLMK 640 kr..gikrslai.llvlllflvalvllgvllipllinqltqLikslPtgd +++++ik l ++ll +l+ ++ +++++ + +ll q L++++ NP_036459. 641 RKdsFIKEELLVhLLQVLSTVLSMYVVYSTQSSLLRKQGLPLMNQII--S 688 yidslqnwlnelpeslpelealdasvviqqlnsslsdilsnilssilnsl + + +++ l s p+l + ++ s+ ls + ++ NP_036459. 689 WATLASSLVVPLL-SSPVL-----------FQRLFSILLSLMSTYL---- 722 lsllasltglllqlilvLvllfffLldgekl.......rqgiisllPkry ll++ + l+ l+l +++++ + e+l++++ +q+++s+ + + NP_036459. 723 --LLSTGYEALFPLVLSCLMFVWINIEQETLqqsgvccKQKLTSIQFSYN 770 rervrailrelndtlggylrgqvivaliigvlvfigllilgvpyAlllAl + + + l+d+ +++++ ++v ++ g++ ++++ + lA NP_036459. 771 TDITQFRQLYLDDIRRAFFLVFFLVTAFFGTGNIASINSFD------LAS 814 lvglanlIPyiGpviiliPiaiialltggGiiwaalivlivvllvqqied +++++ ++ p+++ + +++ l + ++v+ + +vq++ NP_036459. 815 VYCFLT---VFSPFMMGAL-MMWKILIPF------VLVMCAFEAVQLTT- 853 niLrPklmgkrlglhPlvillsliaGgslfGlvGlilapPltavlkaild l +k l l +v+++s i+++++f +l+ + NP_036459. 854 -----QLSSKSLFL--IVLVISDIMALHFF-------------FLVKDYG 883 ayr<-* ++ NP_036459. 884 SWL 886 Na_H_Exchanger: domain 1 of 1, from 457 to 890: score -207.7, E = 54 *->illliiillvlakilahlfkrlgkaiPes.lllllaGlllGpiglgl l i+ + + +++ ++k +k+ + +++ +++G+l+++++l NP_036459. 457 YASLL-IIKSHSNLIKGVSKEVKKPSHLLpCSFVAIGILVAFFLLIQ 502 iv.............ldsevffeilLppilFeaGleldlrelfrnlgsil + + + + ++ v++e+ ++ l + l +l+++ +l++ + NP_036459. 503 ACpwtyyvygllplpIWYAVLREFQVIQDLVVSVLTYPLSHFVGYLLAFT 552 l...lAvlGvlisavgiGlllyalvpilgfggq.lvdldllaaLlfGail l+ +++vl + ++++l + ++ ++ + ++ +++ l +f+ +l NP_036459. 553 LgieVLVLSFFYRYMLTAGLTAFAAWPFLTRLWtRAKMTSLSWTFFSLLL 602 sATDPvavlavlkfg.elkrvnkrlgtlifGESllNDavavVllavlisf + + ++v+++++++ +l++G++ll v+ll++++ NP_036459. 603 A---VFPLMPVVGRKpDI--------SLVMGAGLL-----VLLLSLCVVT 636 aqggdnseaveafdifsgvilsflvvflGGiliGlvlgpkfllslitrft ++++ f + ++++l+v + + +v + +sl+++ NP_036459. 637 SLMK----RKDSFIKEEL-LVHLLQVLSTVLSMYVVYS--TQSSLLRKQG 679 ddeg....................PledrliepllvlllaylayllAeml + ++ + + ++ + ++P l + l+ +ll++++ +l + NP_036459. 680 LPLMnqiiswatlasslvvpllssP---VLFQRLFSILLSLMSTYLLLST 726 glSgilavfaaGlalsnayveaniseksrttvkyfwkmlsflfepliFvl g ++ ++ l++ + ni ++t+ + + + + ++ F + NP_036459. 727 GYEALFPLVLSCLMFVW----INI---EQETLQQSGVCCKQKLTSIQFSY 769 lGlsldlsvlhnwanie.DlsestviafillaivaillaRaigVflltll ++d+ ++ ++ D+ i+ + +++++++ a ++g + + + NP_036459. 770 ---NTDITQFRQL---YlDD-----IRRAFFLVFFLVTA-FFGTGNIASI 807 lnffrrekr.snpvsehitfrdqlvigwgGilRGaValalAlsgpltled +f+ + + +t+ +++g + ++ ++++l+ + NP_036459. 808 NSFDLASVYcF------LTVFSPFMMGALMMWKILIPFVLVMCA-----F 846 gtsgpardlilttaivvvlvTvlvqGitlkplvk....klkvke<-* +++ + ++l +++vlv + + +lvk+ +++l++ + NP_036459. 847 EAVQLTTQLSSKSLFLIVLVISDIMALHFFFLVKdygsWLDIGT 890 Sdh_cyt: domain 1 of 1, from 816 to 908: score -55.4, E = 7.7 *->kklnRPiSPHLTIYkpQltsilSIlHRISGvaLalgvllftllLkll + LT+++p ++ al++ +++ ++l+ NP_036459. 816 YC-------FLTVFSPFMMG-------------ALMMWKILIPFVLV 842 tlslesfafyslsvwslnkfskwliivikvfilyalfYHlfnGIRHLiWD + +e+ ++ ++ + k++ ++i++ i+ + + H+f +L+ D NP_036459. 843 MCAFEAVQLTTQ---LSSKSL----FLIVLVISDIMALHFF----FLVKD 881 lGygleiegvyksgayivlvlsvvLall<-* G +l+i + +iv + +++L++l NP_036459. 882 YGSWLDIGTSISHY-VIVMSMTIFLVFL 908 Papilloma_E5: domain 1 of 1, from 835 to 917: score -44.9, E = 48 *->illvFlLCFcVlLclClll....RPLlLSvsvYAaLLlLVLClL... il F+L c + + l+ + ++ +L+L v v + + L + +L ++ NP_036459. 835 ILIPFVLVMCAFEAVQLTTqlssKSLFLIVLVISDIMALHFFFLvkd 881 ...WVfvtSpLraFivYl...iFlYLPlflIHlHAqyLlq<-* ++W +++ ++ + +iFl ++ Aq+L++ NP_036459. 882 ygsWLDIGTSISHYVIVMsmtIFLV----FLNGLAQLLTT 917 DUF205: domain 1 of 1, from 765 to 917: score -132.5, E = 98 *->lllAYLlGSIpfGylvgKLllgvDiRkvGSgNpGATNVlRaLqskGv + + Y + + + l++ DiR Ra+ NP_036459. 765 IQFSY-----NTDITQFRQLYLDDIR-------------RAF----- 788 snGkkaAllVlifDilKGmlAvllarliFglgLQqYLtvkvYQdswpLgm +lV+++ + A++++ i ++ s+ L NP_036459. 789 -------FLVFFL-----VTAFFGTGNIASI------------NSFDLAS 814 vAWqnWLtLGvclaAvLGHifPvFfkFkGGKgVATslGvlla...lspwl v c+ v f++F +G+l + + l+p + NP_036459. 815 VY---------CFLTV----FSPFM-----------MGALMMwkiLIPFV 840 aliml..avWLlviLltkYVSLaSivtai..aaavliLfvwlpylyffks + ++ +av L++ L +k SL iv +i+++ a+ ++f+ + y + NP_036459. 841 LVMCAfeAVQLTTQLSSK--SLFLIVLVIsdIMALHFFFLVKD--YGSWL 886 dPlkaIv.yqlkevitlffvlLigPLTilviyrHReNIkRLlnG<-* d +I++y t+f+v+L g + Ll+ NP_036459. 887 DIGTSIShYVIVMSMTIFLVFLNG-------------LAQLLTT 917 MVIN: domain 1 of 1, from 549 to 926: score -272.4, E = 39 *->iAayfGAgllaDaFnvAFriPNllRrLfaiEGafssAFvPvfaelks +A ++G +l+ +F++ ++ L+a + + +A P++++l NP_036459. 549 LAFTLGIEVLVLSFFYRYM-------LTA-GLTAFAAW-PFLTRLW- 585 aqdkdeaaeFvrkvstllilvlllvtll.......gilaapwvirllapg + + ++++ +++ ll +v l +++++++ + + +a ++++ll+ NP_036459. 586 --TRAKMTSLSWTFFSLLLAVFPLMPVVgrkpdisLVMGAGLLVLLLSLC 633 fa........daekfsLtvsllritfPylllvsLsavfgavLNarkkFfa + ++ ++++ ++k++L v ll+++ l ++ +++ +++L ++ NP_036459. 634 VVtslmkrkdSFIKEELLVHLLQVLSTVLSMYVVYSTQSSLLRKQGL--- 680 pafsPvllNivvIltllflanyfgrepiyevkvtiwleaellLaiGvliG P ++ i+ +tl +++ ++ + NP_036459. 681 ----PLMNQIISWATLASSLVVPL---LS---------S----------P 704 GvlQlLvqlpf.lrkaglldftklkprfnfrdkgvkrflklalptllgvs +++Q L+ + +l+ ++ll g +++ l l l++v NP_036459. 705 VLFQRLFSILLsLMSTYLL-----------LSTGYEALFPLVLSCLMFVW 743 v.......sQlnllidtalASfaqlkeGsisylyYAdriyqLPlGiFgvs ++ ++++ +Q + + + l+S NP_036459. 744 InieqetlQQSGVCCKQKLTSI---------------------------- 765 vstvlLPrlSrsaksgdwdefrdl.ldqairltllltiPasfgllvLSdp +S + d+ +fr+l ld+ r +l+++++++++ + NP_036459. 766 -------QFS---YNTDITQFRQLyLDDIRRAFFLVFFLVTAFFGTGNIA 805 IvsvLyerGaFsaedvtatasvLaayalGLipyaLvklLsrvFYAredtk ++ +F+ +v+ +v++ + G + ++ k+L++ + NP_036459. 806 SIN------SFDLASVYCFLTVFSPFMMG--ALMMWKILIP--------F 839 tPfkislisavlnillslvayllllpplgvvGlAlAtslsawinlvfLyy + + ++ ++ l++ ls + l ++ l+++ ++ ++ NP_036459. 840 VLVMCAFEAVQLTTQLS-------SKSLFLIVLVISDIMAL------HFF 876 llrkrlvgDghsargiktflasgvlvvltalmsgvilllssltqgewvvg +l k + s++ i t++ v+++ m + +++l+ l q + NP_036459. 877 FLVKD----YGSWLDIGTSISH---YVIVMSMTIFLVFLNGLAQ---LLT 916 slllilvgvl<-* + +l+l g + NP_036459. 917 TKKLRLCGKP 926 TrkH: domain 1 of 1, from 540 to 928: score -233.8, E = 47 *->pltlrlshyFlivvligliasllltlPlitrsdlplsfiDAlFtatS pl++ + +l++ ++g + l l+++ r ++ A ta+ NP_036459. 540 PLSHFVG--YLLAFTLG---IEVLVLSFFYRY-----MLTAGLTAFA 576 Av.TvTGl...tvvdtleslsksglflrslLqqiGGsa.psllqdnsdlG A++ T l +++ ++ l++ s l+ L+ G+ ++ l + l NP_036459. 577 AWpFLTRLwtrAKMTSLSWTFFSLLLAVFPLMPVVGRKpDISLVMGAGLL 626 fmvlavlillllgkklgrnsslkgrllyqeellgeieygsikllpsilft + l+ ++ +l k+ + ++eell l ++l+t NP_036459. 627 VLLLSLCVVTSLMKR--------KDSFIKEELLVH--------LLQVLST 660 afiielIyalllilcfillygtgmsvvdkisrlfdAiFhsiSafnNaGfS +++++++y+ +l+ + m+ + +A + S + + NP_036459. 661 VLSMYVVYSTQSSLLRK-QGLPLMN-----QIISWA-TLASSLV-----V 698 ltsdSmisfrn.lnpfvllvtsfliIlGG..tgFpvlldvliwirkkitk + S + f+ +++ + l + l + G + +Fp+ l++l ++ i + NP_036459. 699 PLLSSPVLFQRlFSILLSLMSTYLLLSTGyeALFPLVLSCLMFVWINIEQ 748 ..........kg.sqfkelslflkdherrtflnL..lllsfitilllevl ++ ++++ k + + ++s+++ ++++r L+++ +f+++++l + NP_036459. 749 etlqqsgvccKQkLTSIQFSYNTDITQFRQLY-LddIRRAFFLVFFLVTA 797 glgnatdtifFmvLDlgSsvvgslsegdrllnsfFqsVStlRTAGFstiD +g g + +S +++D NP_036459. 798 FFG----------------------TG--------NIASI------NSFD 811 lsqlspatlvllmllMfIGgspgSTaGGIKtttfalillalyaelrlahp l++ + v+ ++M + + K+ +++ ++ ++ + NP_036459. 812 LASVYCFLTVFSPFMMGALM-------MWKILIPFVLVMCAFEAVQ---- 850 gavevkifgrsilqrqiiralwvfflglfivciveflllitegypdfsfl ++ +++l+ ++l + + f +l+ + ++ l NP_036459. 851 -----------LTTQLSSKSLFLIVLVISDIMALHFFFLVKDYGS---WL 886 dslFEvvSAfGTVGLSlGlvktanlslspqfstlgKlvlIilMiiGRhRl d+ G +++ ++ + + ++ + G +l NP_036459. 887 DI---------------GTSISHYVIVM-------SMTIFLVFLNGLAQL 914 giftllvawfvkpsw<-* + l++ +kp++ NP_036459. 915 LTTKKLRL-CGKPKS 928 // Start with PfamFrag (from /data/patterns/pfam) hmmpfam - search a single seq against HMM database HMMER 2.1.1 (Dec 1998) Copyright (C) 1992-1998 Washington University School of Medicine HMMER is freely distributed under the GNU General Public License (GPL). - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /data/patterns/pfam/PfamFrag Sequence file: NP_036459.1.fa - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: NP_036459.1 phosphatidylinositol glycan, class N; [Homo sapiens]. Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Steroid_dh 3-oxo-5-alpha-steroid 4-dehydrogenase 4.8 1.5 1 DUF6 Integral membrane protein DUF6 2.7 33 1 Ribosomal_L14 Ribosomal protein L14p/L23e 2.2 30 1 Fusion_gly_K Cell fusion glycoprotein K 1.5 16 1 Carla_C4 Carlavirus putative nucleic acid bind 1.1 62 1 tRNA_int_endo_N tRNA intron endonuclease, N-terminal 1.1 68 1 ABC_membrane ABC transporter transmembrane region. 0.9 51 1 oxidored_q3 NADH-ubiquinone/plastoquinone oxidore 0.9 37 1 Lipoprotein_4 Periplasmic solute binding protein fa 0.9 30 1 PsbJ PsbJ 0.8 77 1 CutA1 CutA1 divalent ion tolerance protein 0.7 69 1 KdpC K+-transporting ATPase, c chain 0.4 28 1 Transposase_20 Transposase IS116/IS110/IS902 family 0.1 96 1 CAT Chloramphenicol acetyltransferase 0.0 99 1 cytochrome_b_N Cytochrome b(N-terminal)/b6/petB -0.5 68 1 ART NAD:arginine ADP-ribosyltransferase -0.8 77 1 HP_OMP_2 Putative outer membrane protein -1.3 64 1 FMO-like Flavin-binding monooxygenase-like -1.5 90 1 Rhabd_glycop Rhabdovirus spike glycoprotein -1.8 73 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- tRNA_int_endo_N 1/1 413 424 .. 67 78 .] 1.1 68 Ribosomal_L14 1/1 409 425 .. 117 133 .] 2.2 30 oxidored_q3 1/1 436 456 .. 1 21 [. 0.9 37 CutA1 1/1 459 479 .. 52 72 .. 0.7 69 ABC_membrane 1/1 436 503 .. 1 66 [. 0.9 51 Lipoprotein_4 1/1 492 507 .. 1 21 [. 0.9 30 HP_OMP_2 1/1 590 597 .. 585 592 .] -1.3 64 DUF6 1/1 573 638 .. 1 65 [. 2.7 33 Rhabd_glycop 1/1 625 648 .. 1 26 [. -1.8 73 ART 1/1 621 651 .. 1 37 [. -0.8 77 FMO-like 1/1 704 715 .. 525 536 .] -1.5 90 Carla_C4 1/1 768 777 .. 85 94 .] 1.1 62 CAT 1/1 769 786 .. 105 122 .. 0.0 99 Steroid_dh 1/1 834 841 .. 202 209 .] 4.8 1.5 Transposase_20 1/1 840 861 .. 92 113 .] 0.1 96 cytochrome_b_N 1/1 861 883 .. 201 222 .] -0.5 68 PsbJ 1/1 882 892 .. 29 39 .] 0.8 77 Fusion_gly_K 1/1 888 908 .. 1 22 [. 1.5 16 KdpC 1/1 892 911 .. 1 20 [. 0.4 28 Alignments of top-scoring domains: tRNA_int_endo_N: domain 1 of 1, from 413 to 424: score 1.1, E = 68 *->sfEELvkrareV<-* +f+E+v++ +e NP_036459. 413 KFDEVVSLCKEL 424 Ribosomal_L14: domain 1 of 1, from 409 to 425: score 2.2, E = 30 *->lRekgFmkIaSlApeVl<-* ++ ++F ++Sl++e + NP_036459. 409 IKHRKFDEVVSLCKELI 425 oxidored_q3: domain 1 of 1, from 436 to 456: score 0.9, E = 37 *->mtyivliLsillvlGflgVas<-* +ty ++L++ +v+Gf+g +s NP_036459. 436 HTYDRFFLGVNVVIGFVGWIS 456 CutA1: domain 1 of 1, from 459 to 479: score 0.7, E = 69 *->vlLIiKTseekfpeLeervke<-* +lLIiK+ + +++ + ++vk+ NP_036459. 459 SLLIIKSHSNLIKGVSKEVKK 479 ABC_membrane: domain 1 of 1, from 436 to 503: score 0.9, E = 51 *->lliailllilagatalvt.fplllgrlldsgfplsdgnddh..arss + ++l + +++++v+ +++ + ++++s ++l++g ++ + +s+ NP_036459. 436 HTYDRFFLGVNVVIGFVGwISYASLLIIKSHSNLIKGVSKEvkKPSH 482 lislailslfavfvliglllqg<-* l+ +++ +++++v+++ll+q+ NP_036459. 483 LLPCSFV-AIGILVAFFLLIQA 503 Lipoprotein_4: domain 1 of 1, from 492 to 507: score 0.9, E = 30 *->alllaalfllaacssetaasa<-* ++l+a+++l++ac ++ NP_036459. 492 GILVAFFLLIQACP-----WT 507 HP_OMP_2: domain 1 of 1, from 590 to 597: score -1.3, E = 64 *->MtnisykF<-* Mt++s+ F NP_036459. 590 MTSLSWTF 597 DUF6: domain 1 of 1, from 573 to 638: score 2.7, E = 33 *->fiWalytvfskklle...spltftawrfliagilllilllflkkgpp ++a++ ++++++++ + ++l+ t++ +l+a ++l+++ ++p NP_036459. 573 TAFAAWPFLTRLWTRakmTSLSWTFFSLLLAV---FPLMPVVGRKPD 616 llallslk.ilallylgilgta<-* ++++ + + ll l+++ ++ NP_036459. 617 ISLVMGAGlLVLLLSLCVVTSL 638 Rhabd_glycop: domain 1 of 1, from 625 to 648: score -1.8, E = 73 *->llsliiillltdsqlgkRiPivfpss<-* ll+l+++l++++s+ + + f+ + NP_036459. 625 LLVLLLSLCVVTSLMKR--KDSFIKE 648 ART: domain 1 of 1, from 621 to 651: score -0.8, E = 77 *->mpalhfvLllSVglllstqalssaiqqkdglvkelvL<-* m a++ vLll s+ + s+ +kd ++ke+ L NP_036459. 621 MGAGLLVLLL------SLCVVTSLMKRKDSFIKEELL 651 FMO-like: domain 1 of 1, from 704 to 715: score -1.5, E = 90 *->vvllvaiflall<-* +vl+ ++f++ll NP_036459. 704 PVLFQRLFSILL 715 Carla_C4: domain 1 of 1, from 768 to 777: score 1.1, E = 62 *->SyNvkVadFI<-* SyN+++ +F+ NP_036459. 768 SYNTDITQFR 777 CAT: domain 1 of 1, from 769 to 786: score 0.0, E = 99 *->ydeDFkeFyknYlsDiae<-* y+ D+++F + Yl+Di++ NP_036459. 769 YNTDITQFRQLYLDDIRR 786 Steroid_dh: domain 1 of 1, from 834 to 841: score 4.8, E = 1.5 *->kaLIPFvl<-* k+LIPFvl NP_036459. 834 KILIPFVL 841 Transposase_20: domain 1 of 1, from 840 to 861: score 0.1, E = 96 *->aLymgAlvalrhledpgsrayy<-* +L+m+A+ a++ + + +s++++ NP_036459. 840 VLVMCAFEAVQLTTQLSSKSLF 861 cytochrome_b_N: domain 1 of 1, from 861 to 883: score -0.5, E = 68 *->FlLPfillillllHLlfL.HetG<-* Fl+ +++ +++lH++fL + +G NP_036459. 861 FLIVLVISDIMALHFFFLvKDYG 883 PsbJ: domain 1 of 1, from 882 to 892: score 0.8, E = 77 *->YGsysglgssl<-* YGs+ +g s+ NP_036459. 882 YGSWLDIGTSI 892 Fusion_gly_K: domain 1 of 1, from 888 to 908: score 1.5, E = 16 *->lLggrtlhLavlgliTaYavll<-* +g+++ h ++ +T+++v+l NP_036459. 888 -IGTSISHYVIVMSMTIFLVFL 908 KdpC: domain 1 of 1, from 892 to 911: score 0.4, E = 28 *->irnLlpALsslllLlviTgl<-* i+ ++ s++++L + gl NP_036459. 892 ISHYVIVMSMTIFLVFLNGL 911 // Start with Repeat Library (from /data/patterns/repeats-Miguel-Andrade/hmm) hmmpfam - search a single seq against HMM database HMMER 2.1.1 (Dec 1998) Copyright (C) 1992-1998 Washington University School of Medicine HMMER is freely distributed under the GNU General Public License (GPL). - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /data/patterns/repeats-Miguel-Andrade/hmm/repeats.hmm-lib Sequence file: NP_036459.1.fa - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: NP_036459.1 phosphatidylinositol glycan, class N; [Homo sapiens]. Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- [no hits above thresholds] Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- [no hits above thresholds] Alignments of top-scoring domains: [no hits above thresholds] // ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ Start with Prosite --------------------------------------------------------- | ppsearch (c) 1994 EMBL Data Library | | based on MacPattern (c) 1990-1994 R. Fuchs | --------------------------------------------------------- PROSITE pattern search started: Wed May 15 16:57:17 2002 Sequence file: NP_036459.1.fa ---------------------------------------- Sequence NP_036459.1 (931 residues): Matching pattern PS00001 ASN_GLYCOSYLATION: 128: NESK 192: NQSL 350: NNTD Total matches: 3 Matching pattern PS00004 CAMP_PHOSPHO_SITE: 478: KKPS 641: RKDS Total matches: 2 Matching pattern PS00005 PKC_PHOSPHO_SITE: 223: SSR 376: TQK 856: SSK 916: TTK 917: TKK Total matches: 5 Matching pattern PS00006 CK2_PHOSPHO_SITE: 18: SIFD 172: TKLD 223: SSRD 726: TGYE 884: SWLD Total matches: 5 Matching pattern PS00008 MYRISTYL: 84: GISHTR 167: GAQDAT 212: GIDTNG 269: GSHGAG 492: GILVAF 802: GNIASI 889: GTSISH Total matches: 7 Matching pattern PS00009 AMIDATION: 611: VGRK Total matches: 1 Matching pattern PS00029 LEUCINE_ZIPPER: 710: LFSILLSLMSTYLLLSTGYEAL Total matches: 1 Total no of hits in this sequence: 24 ======================================== 1314 pattern(s) searched in 1 sequence(s), 931 residues. Total no of hits in all sequences: 24. Search time: 00:00 min ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ Start with Profile Search ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ Start with motif search against own library ***** bioMotif : Version V41a DB, 1999 Nov 11 ***** SeqTyp=2 : PROTEIN search; >APC D-Box is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >ER-GOLGI-traffic signal is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >INTRA-SIGNAL-M minimal SH3 binding is the MOTIF name >NP_036459.1 phosphatidylinositol glycan, class N; [Homo sapiens]. ;LENGTH=931; DIRECT_SEQUENCE n 2 solutions m %_PXXP 38-41 f m %_PXXP 606-609 f >STATISTICS Total : 2 solutions in 1 sequences, 931 units; out of 1 sequences, 931 units >INTRA-SIGNAL-M deubiquitinating enzyme SH3 domain binding motif (Kato, 2000) is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >INTRA-SIGNAL-M minimal class I consensus-SH3 binding motif is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >INTRA-SIGNAL-M minimal class II consensus-SH3 binding motif is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >INTRA-SIGNAL-M exact 14-3-3 binding consensus (Muslin 1996 Cell 84 889) is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >INTRA-SIGNAL-M 14-3-3 binding motif in RAF and others (Muslin 1996 Cell 84 889) is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >INTRA-SIGNAL-M WW domain binding motif in formins (Bedford 1997) is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >INTRA-SIGNAL-M PY motif for WW domain is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >TM-CYTOPLASMIC-M di-hydrophobic endocytosis motifs for internalized transmembrane proteins is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >TM-CYTOPLASMIC-M tyrosine-based endocytosis motif for internalized transmembrane proteins is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >TM-EXTRACELL-M Endocytosis signal for internalized transmembrane proteins is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >EXTRACELL-M minimal furin protease cleavage site motif is the MOTIF name >NP_036459.1 phosphatidylinositol glycan, class N; [Homo sapiens]. ;LENGTH=931; DIRECT_SEQUENCE n 1 solutions m %_RXXR 403-406 f >STATISTICS Total : 1 solutions in 1 sequences, 931 units; out of 1 sequences, 931 units >EXTRACELL-M extended furin protease cleavage site motif is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >EXTRACELL-M zinc binding motif in MMPs is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >EXTRACELL-M g alpha binding go loco is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS PDX-1 experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS QKI-5 experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS HCDA experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS SV40 LrgT experimentally determined is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS H2B experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS v-Rel experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS Amida experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS Amida experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS RanBP3 experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS Pho4p experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS DNAhelicaseQ1 experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS LEF-1 experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS TCF-1 experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR p53-NLS1 NLS experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS hum-Ku70 experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS GAL4 experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS act/inh betaA experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS BDV-P experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS BDV-P experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS BDV-P experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS TR2 experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS THOV NP experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS polyomaVP1 experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS HIV-1 Tat experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS HIV-1 Rev experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS Rex experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS SRY experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS SRY experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS SOX9 experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS SOX9 experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS NS5A experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS DNAse EBV experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS DNAse EBV experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS adenovE1a experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS ystDNApolalpha experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS hVDR experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS CPV capsid experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS hGlu.cort.experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS cFOS experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS cJUN experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS hDNApolalpha experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS hDNAtopoII experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS hDNAtopoII experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS hBLM experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS hARNT experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS influenzaNP experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS influenzaNP experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS p54 experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS hProTalpha experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS Tst1/Oct6 experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS protHsc9 experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS protHsci experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS protHsc3 experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS Ta alpha experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS Pax-QNR experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS Hunt.Dis.pro experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS MyoD experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS MyoD experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS opaque2 experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS CTP experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS HCV experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS HCV experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS p110RB1 experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS VirD2-Nterm experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS VirD2-Cterm experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS Nucloplasmin experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS Nucleolin experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS ICP-8 experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS Nab2 experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS M9 experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS lscMyc experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS humKprotein experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS FluA experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS Mat-alpha experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS polyoma Lrg-T experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS polyoma Lrg-T experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS SV40 VP1 experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS SV40 VP2 experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS polyoma VP2 experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS c-myb experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS N-myc experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS p53 experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS c-erb-A experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS yeast SKI3 experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS L29 experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS L29 experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS Max experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS L3 experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >NUCLEAR NLS dyskerin experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >PDZ domain binding motif science 278_2075_pawson is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units >WW domain binding motif science 278_2075_pawson is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 931 units ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~ ~~~ Start with HMM-search search against own library hmmpfam - search a single seq against HMM database HMMER 2.1.1 (Dec 1998) Copyright (C) 1992-1998 Washington University School of Medicine HMMER is freely distributed under the GNU General Public License (GPL). - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /data/patterns/own/own-hmm.lib Sequence file: NP_036459.1.fa - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: NP_036459.1 phosphatidylinositol glycan, class N; [Homo sapiens]. Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- [no hits above thresholds] Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- [no hits above thresholds] Alignments of top-scoring domains: [no hits above thresholds] // hmmpfam - search a single seq against HMM database HMMER 2.1.1 (Dec 1998) Copyright (C) 1992-1998 Washington University School of Medicine HMMER is freely distributed under the GNU General Public License (GPL). - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /data/patterns/own/own-hmm-f.lib Sequence file: NP_036459.1.fa - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: NP_036459.1 phosphatidylinositol glycan, class N; [Homo sapiens]. Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- [no hits above thresholds] Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- [no hits above thresholds] Alignments of top-scoring domains: [no hits above thresholds] // ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ L. Aravind's signalling DB+ PSSM from other authors IMPALA version 1.1 [20-December-1999] Reference: Alejandro A. Schaffer, Yuri I. Wolf, Chris P. Ponting, Eugene V. Koonin, L. Aravind, Stephen F. Altschul (1999), "IMPALA: Matching a Protein Sequence Against a Collection of "PSI-BLAST-Constructed Position-Specific Score Matrices", Bioinformatics 15:1000-1011. Query= NP_036459.1 phosphatidylinositol glycan, class N; [Homo sapiens]. (931 letters) Searching..................................done Results from profile search Score E Sequences producing significant alignments: (bits) Value DHHC Novel zinc finger domain with DHHC signature 24 1.1 SH2 Src Homology domain 2 23 2.1 BHLH basic helix-loop-helix domain 22 2.9 PUM Pumilio repeat RNA binding domain 22 2.9 SNARE Alpha helical domains which are involved in vesicle fu... 22 3.5 FYVE Zinc Finger domain involved in PtdIns(3)P binding 21 6.5 DNASE1 DNASE-1/Sphingomyelinase like domain 21 8.7 HSF Heat Shock Factor Domain (Winged helix type DNA binding ... 21 8.7 BRIGHT BRIGHT domain (Alpha helical DNA binding domain) 21 9.1 >DHHC Novel zinc finger domain with DHHC signature Length = 217 Score = 23.6 bits (50), Expect = 1.1 Identities = 7/41 (17%), Positives = 7/41 (17%), Gaps = 4/41 (9%) Query: 491 IGILVAFFLLIQACPWTYYVYGLL--PLPIWYAVLREFQVI 529 Sbjct: 54 VAWLLYLFFAV--IGFGILVPLLPHHWVPAGYACMGAIFAG 92 Score = 23.2 bits (49), Expect = 1.5 Identities = 5/30 (16%), Positives = 5/30 (16%) Query: 7 LGLLIHFVFFASIFDIYFTSPLVHGMTPQF 36 Sbjct: 54 VAWLLYLFFAVIGFGILVPLLPHHWVPAGY 83 >SH2 Src Homology domain 2 Length = 119 Score = 22.9 bits (49), Expect = 2.1 Identities = 12/37 (32%), Positives = 12/37 (32%), Gaps = 4/37 (10%) Query: 861 FLIVLVISDIMALHFFFLVKDYGSWLDIGTSISHYVI 897 Sbjct: 31 FLIRE--SETLKGSFSLSVRDYDPMHG--DVIKHYKI 63 >BHLH basic helix-loop-helix domain Length = 103 Score = 22.2 bits (47), Expect = 2.9 Identities = 6/11 (54%), Positives = 6/11 (54%) Query: 401 ILRKARSYIKH 411 Sbjct: 49 TLRLARNYIDA 59 >PUM Pumilio repeat RNA binding domain Length = 337 Score = 22.1 bits (47), Expect = 2.9 Identities = 3/28 (10%), Positives = 3/28 (10%) Query: 224 SRDYKHNIKKVDDGVKEIVSMFNHFYGN 251 Sbjct: 291 NASMNILLTTIDIFTVNLNVLIRDNFGN 318 >SNARE Alpha helical domains which are involved in vesicle fusion Length = 254 Score = 22.1 bits (47), Expect = 3.5 Identities = 13/45 (28%), Positives = 13/45 (28%), Gaps = 4/45 (8%) Query: 460 LLIIKSHSNLIKGVSKEVKKPSHLLPCSFVAIGILVAFFLLIQAC 504 Sbjct: 198 LSLLCGALNLIRGFHAI----ESLLQSDGEDFSYMIAFFLGTAAC 238 >FYVE Zinc Finger domain involved in PtdIns(3)P binding Length = 99 Score = 21.2 bits (44), Expect = 6.5 Identities = 7/19 (36%), Positives = 7/19 (36%) Query: 755 GVCCKQKLTSIQFSYNTDI 773 Sbjct: 69 GSCCDNWTTYPPMGYETKI 87 >DNASE1 DNASE-1/Sphingomyelinase like domain Length = 388 Score = 20.9 bits (43), Expect = 8.7 Identities = 11/100 (11%), Positives = 11/100 (11%), Gaps = 10/100 (10%) Query: 385 FLFTPFKLLSDSKQFNILRKARSYIKHRKFDEV----VSLCKELIHLALKGLSYYHTYDR 440 Sbjct: 119 FIMCPMEALKWEERKYLI---LEEILMYQPDVLCLQEVDHYFDTFQPILSRLGYQCTFLA 175 Query: 441 FFLGVNVVIGFVGWISYASLLIIKSHSNLIKGVSKEVKKP 480 Sbjct: 176 KPWSPC--LDVEHNNGPDGCALF-FLQDRFQLVNSAKIRL 212 >HSF Heat Shock Factor Domain (Winged helix type DNA binding domain) Length = 112 Score = 20.6 bits (43), Expect = 8.7 Identities = 4/18 (22%), Positives = 4/18 (22%) Query: 681 PLMNQIISWATLASSLVV 698 Sbjct: 15 HRTDDVVSWNEEGTAFVV 32 >BRIGHT BRIGHT domain (Alpha helical DNA binding domain) Length = 172 Score = 20.7 bits (43), Expect = 9.1 Identities = 8/33 (24%), Positives = 8/33 (24%), Gaps = 1/33 (3%) Query: 59 LYELDENGNSRAPFIRNIIMHEGSWGISHTRVP 91 Sbjct: 15 LYEINDD-PKRKEFLDDLFSFMQKRGTPINRLP 46 Underlying Matrix: BLOSUM62 Number of sequences tested against query: 105 Number of sequences better than 10.0: 9 Number of calls to ALIGN: 10 Length of query: 931 Total length of test sequences: 20182 Effective length of test sequences: 16536.0 Effective search space size: 14831514.2 Initial X dropoff for ALIGN: 25.0 bits Y. Wolf's SCOP PSSM IMPALA version 1.1 [20-December-1999] Reference: Alejandro A. Schaffer, Yuri I. Wolf, Chris P. Ponting, Eugene V. Koonin, L. Aravind, Stephen F. Altschul (1999), "IMPALA: Matching a Protein Sequence Against a Collection of "PSI-BLAST-Constructed Position-Specific Score Matrices", Bioinformatics 15:1000-1011. Query= NP_036459.1 phosphatidylinositol glycan, class N; [Homo sapiens]. (931 letters) Searching.................................................done Results from profile search Score E Sequences producing significant alignments: (bits) Value gi|1345687 [59..410] Heme-dependent peroxidases 29 0.23 gi|232142 [190..392] P-loop containing nucleotide triphospha... 29 0.26 gi|1072178 [17..364] Phosphoglycerate mutase-like 28 0.68 gi|2829864 [79..325] Metzincin-like 27 1.1 gi|115682 [1..213] CoA-dependent acetyltransferases 26 2.0 gi|1708407 [3..471] Isocitrate & isopropylmalate dehydrogena... 26 3.0 gi|1280085 [6..334] beta/alpha (TIM)-barrel 25 4.5 gi|1168472 [55..543] Periplasmic binding protein-like II 25 5.2 gi|2809057 [242..451] Metzincin-like 25 5.3 gi|730289 [27..419] Single-stranded right-handed beta-helix 25 6.1 gi|666883 [313..633] beta/alpha (TIM)-barrel 25 6.2 gi|2780210 [404..848] beta/alpha (TIM)-barrel 25 6.5 gi|1044824 [27..332] Phosphoglycerate mutase-like 24 7.3 gi|433311 [68..521] DNA/RNA polymerases 25 7.5 gi|139813 [192..507] Periplasmic binding protein-like II 25 7.8 gi|2244909 [587..959] beta/alpha (TIM)-barrel 25 8.1 >gi|1345687 [59..410] Heme-dependent peroxidases Length = 352 Score = 29.4 bits (65), Expect = 0.23 Identities = 28/125 (22%), Positives = 28/125 (22%), Gaps = 20/125 (16%) Query: 221 RPSSRDYKHNIKKVDDGVKEIVSMF--NHFYG---NDGKTTFIFTSD-------HGMTDW 268 Sbjct: 178 KAAARDIRETFRRMGMNDEETVALIAGGHTFGKAHGAGPATHVGPEPEAAPIEAQGLGWI 237 Query: 269 GSHGAGHPSETLTPLVTWGAGIKYPQRVSAQQFDDAFLKEWRLE-------NWKRLDVNQ 321 Sbjct: 238 SSYGKGKGSDTITSGIE-GAWTPTPTQWDTSYFDMLFGYDWWLTKSPAGAWQWMAVDPDE 296 Query: 322 ADIAP 326 Sbjct: 297 KDLAP 301 >gi|232142 [190..392] P-loop containing nucleotide triphosphate hydrolases Length = 203 Score = 29.5 bits (65), Expect = 0.26 Identities = 15/152 (9%), Positives = 15/152 (9%), Gaps = 21/152 (13%) Query: 106 YEDVSAVAKGWKENPVEFDSLFNESKYTWSWGSPDILPMFAKGAS-GDHVYTYSYDAKRE 164 Sbjct: 52 VIREDNQTNRLQEALNLFKSIWNNRW----LRTISVILFLNKQDLLAEKVLAGKSKIELF 107 Query: 165 DFGAQDATKLDT--WVFDNVKDFFH----HARNNQSLFSKINEEKIVFFLHLLGIDTNGH 218 Sbjct: 108 VLDDRLFQERPFSFIEDYFPEFARYTTPEDATPEPGEDPRVTRAKY--FIRDEFLRISTA 165 Query: 219 AHRPSSRDYKH--------NIKKVDDGVKEIV 242 Sbjct: 166 SGDGRHYCYPHFTCAVDTENIRRVFNDCRDII 197 >gi|1072178 [17..364] Phosphoglycerate mutase-like Length = 348 Score = 28.0 bits (62), Expect = 0.68 Identities = 9/101 (8%), Positives = 9/101 (8%), Gaps = 13/101 (12%) Query: 656 QVLSTVLSMYVVYSTQSSLLRKQ-GLPLMNQIISWATLASSLVVPLLSSPVLFQRLFS-- 712 Sbjct: 202 GYENRILNMSFLIHDAVVKVQNDSVGDYHNELVMSYFET----HLQKNSTKGV--FISGH 255 Query: 713 --ILLSLMSTYLLLSTGYEALFPLVLSCLMFVWINIEQETL 751 Sbjct: 256 DTNLVTIWES--LRLDGHPEDIPNYGAHIAIEMHEPVGQLS 294 >gi|2829864 [79..325] Metzincin-like Length = 247 Score = 27.2 bits (60), Expect = 1.1 Identities = 25/154 (16%), Positives = 25/154 (16%), Gaps = 31/154 (20%) Query: 116 WKENPVEFDSLFNESKYTWS------------WGSPDILPMFAKGASGDHVYTYSYDAKR 163 Sbjct: 97 RNALTEEVKSVFSRAFTRWEEVTPLTFTRVERFSTSDISIGFYSGEHGDG---EPFDGPM 153 Query: 164 EDF------GAQDA--TKLDTWVFDN-VKDFFHHARNNQSLFSKINEEKIVFFLHLLGID 214 Sbjct: 154 RTLAHAFSPPTGHFHLDGEENWIVSGEGGDGFISVSEAVDLESVAVHE----IGHLLGLG 209 Query: 215 TNGHAHR---PSSRDYKHNIKKVDDGVKEIVSMF 245 Sbjct: 210 HSSVEGSIMYPTIRTGRRKVDLTTDDVEGVQYLY 243 >gi|115682 [1..213] CoA-dependent acetyltransferases Length = 213 Score = 26.5 bits (58), Expect = 2.0 Identities = 10/57 (17%), Positives = 10/57 (17%), Gaps = 6/57 (10%) Query: 759 KQKLTSIQFSYNTDITQFRQLYLDDIRRAFFLVFFLVTAFFGTGNIASINSFDLASV 815 Sbjct: 94 TETFSALSCRYFPDLSEFMAGYNAVTAE-----YQHDTRLFPQGNLPE-NHLNISSL 144 >gi|1708407 [3..471] Isocitrate & isopropylmalate dehydrogenases Length = 469 Score = 26.0 bits (57), Expect = 3.0 Identities = 16/86 (18%), Positives = 16/86 (18%), Gaps = 8/86 (9%) Query: 47 VLFVADGLRADALYELDENGNSRAPFIRNIIMHEGSWGISHT-RVPTESRPGHVALIAGF 105 Sbjct: 238 IMKYTEGAFRDWGYEL---ATSEFRQET--VTERESWILSNKEKNPNISLEDNARQIDPG 292 Query: 106 YEDVSAVAKGW--KENPVEFDSLFNE 129 Sbjct: 293 FDALTPEKKAQIVKEVETVLNSIWES 318 >gi|1280085 [6..334] beta/alpha (TIM)-barrel Length = 329 Score = 25.3 bits (55), Expect = 4.5 Identities = 4/30 (13%), Positives = 4/30 (13%) Query: 111 AVAKGWKENPVEFDSLFNESKYTWSWGSPD 140 Sbjct: 69 VLHEYISSGKLKREDIFVTSKLPFTAHAPE 98 >gi|1168472 [55..543] Periplasmic binding protein-like II Length = 489 Score = 24.9 bits (54), Expect = 5.2 Identities = 21/141 (14%), Positives = 21/141 (14%), Gaps = 29/141 (20%) Query: 139 PDIL-PMFAKGASGDHVYTYSYD--------AKREDFGAQDATKLD---TWVF---DNVK 183 Sbjct: 1 PTLFNSLYSTDDASTDIENMLYSFLTKTDEKLNVKLSLAESIKELDGGLAYDVKIKKGVK 60 Query: 184 DFFHHARNNQSLFSKINEEKIVF-FLHLLGIDTNGHAHRPSSRDYKHNIKKVDDGVKEIV 242 Sbjct: 61 --FHDGK-------ELTADDVVFTYSVPL--SKDYKGERGSTYEMLKSVEKKGDYEVLFK 109 Query: 243 SM--FNHFYGNDGKTTFIFTS 261 Sbjct: 110 LKYKDGNFYNNALDSTAILPK 130 >gi|2809057 [242..451] Metzincin-like Length = 210 Score = 24.9 bits (54), Expect = 5.3 Identities = 17/124 (13%), Positives = 17/124 (13%), Gaps = 23/124 (18%) Query: 227 YKHNIKKVDDGVKEIVSMFNHFYGNDGKTTFIFTSDHGMTDWGSHGAGHPSETLTPLVTW 286 Sbjct: 14 ADFHGSGLKHYLLTLFSVAARFY-KHPSIRNSIS----------------LVVVKILVIY 56 Query: 287 GAGIKYPQRVSAQQFDDAFLKEWRLENWKRLDVNQA--DIAPLMT--SLIGVPFPLNSVG 342 Sbjct: 57 EEQKGPEVTSNAALTLRNFC-NWQKQHNSPSDRDPEHYDTAILFTRQDLCG-SHTCDTLG 114 Query: 343 ILPV 346 Sbjct: 115 MADV 118 >gi|730289 [27..419] Single-stranded right-handed beta-helix Length = 393 Score = 24.9 bits (54), Expect = 6.1 Identities = 23/153 (15%), Positives = 23/153 (15%), Gaps = 26/153 (16%) Query: 138 SPDILPMFAKGASGDHVYTYSYDAKREDFGAQDATKLDTWVFDNVKDFFHHARNNQSLFS 197 Sbjct: 157 AYDYFPQWDPTDGSSGNWNSQYDNITINGGT------HIWI-DHCT-FNDGSRPDST-SP 207 Query: 198 KINEEKIVFFLHLLGIDTNGHAHRPSSRDYKHNIKKV-----------DDGVKEIVSMFN 246 Sbjct: 208 KYYGRKYQHHDGQTDA-SNGANYITMSYNYYHDHDKSSIFGSSDSKTSDDGKLKITLHHN 266 Query: 247 HFYGNDGKTT-----FIFTSDHGMTDWGSHGAG 274 Sbjct: 267 RYKNIVQRAPRVRFGQVHVYNNYYEGSTSSSSY 299 >gi|666883 [313..633] beta/alpha (TIM)-barrel Length = 321 Score = 24.9 bits (53), Expect = 6.2 Identities = 16/185 (8%), Positives = 16/185 (8%), Gaps = 14/185 (7%) Query: 98 HVALIAGFYEDVSAVAKGWKENPVEFDSLFNESKYTWSWGSPDILPMF--AKGASGDHVY 155 Sbjct: 113 VWKHVAAHYAESPREDLFF---ELLNEPDMSDGKVTAAQWTVAAQAMIDAIRTVDTKHTI 169 Query: 156 TYSYDAKREDFGAQDATKLDTWVFDNVKDFFHHARNNQSLFSKINE---EKIVFFLHLLG 212 Sbjct: 170 LFGDAQWYSISLLAKRTPFTDDNIIYVIHTYEPFAFTHQGGSWTDYATIHDIPFPYDPAK 229 Query: 213 IDTNGHAHRPSSRDYKHNIKKVDDGVKEIVSMFNHFYGNDGKTTF------IFTSDHGMT 266 Sbjct: 230 WSTVSGDFGVNKSTKAYVKTNIKNYYKTGSKEAILEQILKAKKWAATNNVPVIINEFGAL 289 Query: 267 DWGSH 271 Sbjct: 290 NLRST 294 >gi|2780210 [404..848] beta/alpha (TIM)-barrel Length = 445 Score = 24.9 bits (53), Expect = 6.5 Identities = 5/82 (6%), Positives = 5/82 (6%), Gaps = 3/82 (3%) Query: 115 GWKENPVEFDSLFNESKYTWSWGSPDILPMFAKGASGDHVYTYSYDAKREDFGAQDATKL 174 Sbjct: 114 GLTVEPKSGKSYYNGDLWSTAEPTGNTCVNWGRPTGAKSPEGYTLYDCQWPS---PTSGM 170 Query: 175 DTWVFDNVKDFFHHARNNQSLF 196 Sbjct: 171 FPKALYHNCWIGNWEGEDSRSC 192 >gi|1044824 [27..332] Phosphoglycerate mutase-like Length = 306 Score = 24.5 bits (53), Expect = 7.3 Identities = 6/51 (11%), Positives = 6/51 (11%), Gaps = 3/51 (5%) Query: 643 DSFIKEELLVHLLQVLSTVLSMYVVYSTQSSLLRKQGLPLMNQIISWATLA 693 Sbjct: 182 AQHINEIMGIY-VNVTQ--FITGTGNHHDPRMMKVKFGNLMNTLLTDIKNK 229 >gi|433311 [68..521] DNA/RNA polymerases Length = 454 Score = 24.6 bits (53), Expect = 7.5 Identities = 23/148 (15%), Positives = 23/148 (15%), Gaps = 15/148 (10%) Query: 366 QILEQFKVKMTQKKEVTLP-FLFTPFKLLSDSKQFNILRKARSYIKHRKFDEVVSLCKEL 424 Sbjct: 294 ALGHLQKIKAGEPKAVTLRQGPKESYKDFIDR----LFQQIDQE----QALEEVRIAKEA 345 Query: 425 IHLALKGLSYYHTYDRFFLGVNVVIGFVGWISYASLLIIK-SHSNLIKGVSK-EVKKPSH 482 Sbjct: 346 IENLTDMSYFDNKKPVYCKFSIVGVHQVAYIVYQDQGQLWMGRMNRQKKKAENTCDIVLR 405 Query: 483 LLP----CSFVAIGILVAFFLLIQACPW 506 Sbjct: 406 AINKVRQEAIVRLGIEPVYQIPCSREIW 433 >gi|139813 [192..507] Periplasmic binding protein-like II Length = 316 Score = 24.5 bits (53), Expect = 7.8 Identities = 17/173 (9%), Positives = 17/173 (9%), Gaps = 31/173 (17%) Query: 177 WVFDNVKDFFHHARNNQSLFSK---------INEEKIVFF-LHLLGIDTNGHAHRPSSRD 226 Sbjct: 145 PWYERGIERPRDLAAAGRILDEAGWKPGSGGIRARDGQRASFTLYYPSGDKVR-QDHALA 203 Query: 227 YKHNIKKVDDGVK-EIVSMFNHFYGNDGKTTFIFTSDHGMTDWGSHGAGHPSETLTPLVT 285 Sbjct: 204 YASDAKKA--GIEVKVEGATWEVIEPRMKTDAVL----ADLGSVGD-PDFGLYTLLHSTL 256 Query: 286 WGAGIKYPQRVSAQQFDDAFLKEW--------RLENWKRLD---VNQADIAPL 327 Sbjct: 257 AGDGFNNMAHYANPAV-DEALDAGRRSQDPKVRAAAYREIQKALVADPGYTFL 308 >gi|2244909 [587..959] beta/alpha (TIM)-barrel Length = 373 Score = 24.5 bits (53), Expect = 8.1 Identities = 18/104 (17%), Positives = 18/104 (17%), Gaps = 14/104 (13%) Query: 58 ALYELDENGNSRAPFIRNIIMHEGSWGISHTRVPTESRPGHVALIAGF-YEDVSAVAKGW 116 Sbjct: 61 FGLVFKFFGADRIKAVRKMIM----------AVTTEQRKASLDILLPYQRSDFEGIFRAM 110 Query: 117 KENPVEFDSL-FNESKYTWSWGSPDILPMFAK--GASGDHVYTY 157 Sbjct: 111 DGLPVTIRLLDPPLHEFLPEGDLDNIVHELAEETGVKEDEVLSR 154 Underlying Matrix: BLOSUM62 Number of sequences tested against query: 1187 Number of sequences better than 10.0: 16 Number of calls to ALIGN: 16 Length of query: 931 Total length of test sequences: 256703 Effective length of test sequences: 209547.0 Effective search space size: 186719770.0 Initial X dropoff for ALIGN: 25.0 bits ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ calculation of internal repeats with prospero ***** PROSPERO v1.3 Wed May 15 16:58:07 2002 ***** Copyright 2000, Richard Mott, Wellcome Trust Centre for Human Genetics, University of Oxford For help see http://www.well.ox.ac.uk/ariadne For usage use -help using gap penalty 11+1k using matrix BLOSUM62 printing all alignments with eval < 0.100000 using sequence1 NP_036459.1 using self-comparison ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ TIGRFAM hmmpfam - search a single seq against HMM database HMMER 2.1.1 (Dec 1998) Copyright (C) 1992-1998 Washington University School of Medicine HMMER is freely distributed under the GNU General Public License (GPL). - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /data/patterns/tigrfam/tigrfam.hmm Sequence file: NP_036459.1.fa - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: NP_036459.1 phosphatidylinositol glycan, class N; [Homo sapiens]. Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- TIGR00880 2_A_01_02: Multidrug resistance protein -44.1 2.5 1 TIGR00077 lspA: lipoprotein signal peptidase -88.8 75 1 TIGR00830 PTBA: pts system, glucose-specific iia comp -92.8 45 1 TIGR00950 2A78: Carboxylate/Amino Acid/Amine Transpor -137.1 51 1 TIGR00861 MIP: MIP family channel proteins -142.1 63 1 TIGR00852 pts-Glc: pts system, maltose and glucose-sp -152.1 4.3 1 TIGR00790 fnt: formate/nitrite transporter -170.0 45 1 TIGR00816 tdt: C4-dicarboxylate transporter/malic aci -177.4 62 1 TIGR00900 2A0121: H+ Antiporter protein -223.3 97 1 TIGR00937 2A51: Chromate Ion Transporter -241.1 36 1 TIGR00893 2A0114: d-galactonate transporter -241.7 72 1 TIGR00800 ncs1: NCS1 nucleoside transporter family -243.2 60 1 TIGR00846 caca2: calcium/proton exchanger -246.9 60 1 TIGR00885 2A0107: l-fucose permease -260.3 72 1 TIGR00895 2A0115: benzoate transport -266.5 25 1 TIGR00801 ncs2: uracil-xanthine permease -302.0 11 1 TIGR00883 2A0106: citrate-proton symport -302.0 98 1 TIGR00909 2A0306: amino acid transporter -304.3 9 1 TIGR00850 lacE: pts system, lactose-specific iibc com -305.0 84 1 TIGR00837 araaP: aromatic amino acid transport protei -307.2 5.4 1 TIGR00785 dass: anion transporter -318.8 41 1 TIGR00792 gph: sugar (Glycoside-Pentoside-Hexuronide) -329.9 44 1 TIGR00836 amt: ammonium transporter -334.3 73 1 TIGR00353 nrfE: c-type cytochrome biogenesis protein -427.8 77 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- TIGR00830 1/1 227 321 .. 1 129 [] -92.8 45 TIGR00077 1/1 500 641 .. 1 183 [] -88.8 75 TIGR00937 1/1 398 694 .. 1 390 [] -241.1 36 TIGR00950 1/1 465 696 .. 1 275 [] -137.1 51 TIGR00895 1/1 363 697 .. 1 413 [] -266.5 25 TIGR00893 1/1 386 724 .. 1 427 [] -241.7 72 TIGR00880 1/1 599 726 .. 1 148 [] -44.1 2.5 TIGR00861 1/1 590 741 .. 1 258 [] -142.1 63 TIGR00846 1/1 471 749 .. 1 393 [] -246.9 60 TIGR00836 1/1 452 756 .. 1 453 [] -334.3 73 TIGR00885 1/1 486 775 .. 1 422 [] -260.3 72 TIGR00909 1/1 438 799 .. 1 451 [] -304.3 9 TIGR00852 1/1 594 832 .. 1 312 [] -152.1 4.3 TIGR00790 1/1 647 838 .. 1 279 [] -170.0 45 TIGR00816 1/1 558 841 .. 1 346 [] -177.4 62 TIGR00900 1/1 564 850 .. 1 387 [] -223.3 97 TIGR00785 1/1 472 855 .. 1 473 [] -318.8 41 TIGR00792 1/1 487 858 .. 1 470 [] -329.9 44 TIGR00837 1/1 617 868 .. 1 391 [] -307.2 5.4 TIGR00801 1/1 559 878 .. 1 480 [] -302.0 11 TIGR00850 1/1 466 881 .. 1 451 [] -305.0 84 TIGR00353 1/1 490 885 .. 1 590 [] -427.8 77 TIGR00883 1/1 665 905 .. 1 413 [] -302.0 98 TIGR00800 1/1 522 928 .. 1 465 [] -243.2 60 Alignments of top-scoring domains: TIGR00830: domain 1 of 1, from 227 to 321: score -92.8, E = 45 *->IvSPisGeivpLdeVpDevFaskimGdGfAIlPtdGevvAPvdGGVk +++++++V+D v I+ ++++ dG k NP_036459. 227 -------YKHNIKKVDDGVKE---------IVSMFNHFYG-NDG--K 254 itkiFpTkHAiGiesdsGvEiLIHiGIDTVkLnGeG.PGE.LEVFtshVe +t+iF + H +d G G+G+P E+L t +V+ NP_036459. 255 TTFIFTSDHGM---TDWGS-------------HGAGhPSEtL---TPLVT 285 eGdkVkkGDpL..leFDlpaikkagldlttPVvvtN<-* G +k ++++ FD++++k+ l + v + NP_036459. 286 WGAGIKYPQRVsaQQFDDAFLKEWRLENWKRLDVNQ 321 TIGR00077: domain 1 of 1, from 500 to 641: score -88.8, E = 75 *->msqslsAnkkglllywlvailligfDqLsKylvlqnfdlgetyinGa + q A+ + +y l + + y+vl+ f + NP_036459. 500 LIQ---ACPWTYYVYGLLPLPIW-------YAVLREFQVIQD----- 531 dnTivalsgvfnItyvrNtGaAFSlLadqgGWqvyflkgLalaIslglvv v ++v+ + L+ + v++l ++l+I ++ + NP_036459. 532 ---LV--------VSVLTY-----PLS--HF--VGYLLAFTLGIEVLVLS 561 FllrykelqkitniaygLIlGGavGNviDRlv.rGsdgVVDfldfylgny F +ry + +t+ a ++ Rl++r+ + f+l NP_036459. 562 FFYRYMLTAGLTAFAA--------WPFLTRLWtRAKMTSLSWTFFSLLL- 602 hGLDRfpiFNlA.......DvsIcvGvilL.llkfFfpkrKkkkd<-* ++F l + ++++D+s++ G++lL ll ++ + + +k NP_036459. 603 ------AVFPLMpvvgrkpDISLVMGAGLLvLLLSLCVVTSLMKR 641 TIGR00937: domain 1 of 1, from 398 to 694: score -241.1, E = 36 *->FLKLGllsFGGPvAhlgymreelVderqWlseasyndlvALaQllPG + +r +r + ++++ ++v L+ NP_036459. 398 --------------QFNILRK----ARSYIKHRKFDEVVSLCK---- 422 PassQvai.ylGylrg..GilGailagvAFvLPsfLlvvaLawlYvqygs + +a ++l y++ ++++ ++ + ++Fv + + L ++ + + NP_036459. 423 -ELIHLALkGLSYYHTydRFFLGVNVVIGFV--GWISYASLLIIKSHS-N 468 LpkavgavfyGlkaavialiAqAvwklgkKlvgaGeGtpdrll....wgi L k+v+ K v+ p+ ll+ + + i NP_036459. 469 LIKGVS-----------------------KEVK----KPSHLLpcsfVAI 491 alvtAlgtilwesewiqLllailvlvLlwrlpptklslkadalkvkLsqk +++A +++ +w+ ++l l + + ++ q NP_036459. 492 GILVAFFLLIQACPWTYYVYGLLPLPIWYAVLR----------EFQVIQD 531 alvaflaLglallalllpladlslasvlaiffkGLkaGaLvFG.GGyvvv + v+ l +l +++ l++ +l+ + + ff+ L+ G ++++ NP_036459. 532 LVVSVLTYPLSHFVGYLLAFTLGIEVLVLSFFY---RYMLTAGlTAFAAW 578 PFLeggvVeryew....LtakQFLDGiAlaqitPGPLvitAtFiGaaqYl PFL +r+ w++ ++t+ + ++ + + a + NP_036459. 579 PFL-----TRL-WtrakMTSLSW---------------TFFSLLL-AVFP 606 vaGllG.....AivaTvaiFLPsFLLvllvlPyfkklkknp..iirafLd + + G++++ + v+ ++ +L +ll+l + +l k+++++i+ L+ NP_036459. 607 LMPVVGrkpdiSLVMGAG-----LLVLLLSLCVVTSLMKRKdsFIKEELL 651 GVnAgvvGLlvAatidlartsavdiptllvfvvlliallkfsYAWkkKlp + ++++ +++ v ++ +ll++ lp NP_036459. 652 ---------------VHLLQVLSTVLSMYVVYSTQSSLLRK-----QGLP 681 .ewlvVllaAliG<-* + ++ a l+ NP_036459. 682 lMNQIISWATLAS 694 TIGR00950: domain 1 of 1, from 465 to 696: score -137.1, E = 51 *->WGttgvvigqyleg.qvplyfavlrrLifglLlLLpllrlrGdkiLi + +++i+ + + +p+ + +++ g+L+ ++ll+ NP_036459. 465 --SHSNLIKGVSKEvKKPSHLLPCSFVAIGILVAFFLLIQ------- 502 lnplkrllrllllgalqigvfyvly..fvAvkrtlpvgeaalllylaPly ++ + ++g+l + + y+ +++f+ ++ l v+ ++ NP_036459. 503 -A---CPWTYYVYGLLPLPIWYAVLreFQVIQD-LVVS----------VL 537 vtllsdLlgkerprklvllAavlglaGavlllsdgNPsnlsidpaGlllg + +ls +g +llA lg+ vl + + NP_036459. 538 TYPLSHFVG-------YLLAFTLGIEVLVLSFFYR-------------YM 567 llsgis.fAlgtVlaKrlvkkegpellqftgfgvlliGallLlpfawll. l++g++ fA+ l++ ++ +++++ l t f +ll++ + L+p+ +++ NP_036459. 568 LTAGLTaFAAWPFLTRLWT-RAKMTSLSWTFF-SLLLAVFPLMPVVGRKp 615 gpnpqllPatslqwgallYLgligtll....aYfLwnkGltlVdpsaasi ++++ ++ a+ l + ll L ++ +l ++++ ++ +++ + ++ + NP_036459. 616 DISL-VMGAGLLVL--LLSLCVVTSLMkrkdSFIK-----EELLVHLLQV 657 lalle..PlvAlLLgllilGetLsliqLiGgalIiaavL<-* l+++ + +v ++ + l+ ++L l i+ + +a++L NP_036459. 658 LSTVLsmYVVYSTQSSLLRKQGLPLMNQIISWATLASSL 696 TIGR00895: domain 1 of 1, from 363 to 697: score -266.5, E = 25 *->DvqnlirkqplsryqwraiilsfLimlvDGlDLaalgfaaPalsaeW ++ ++ ++ ++ +q++ + l fL + L+ + + l ++ NP_036459. 363 NAVQILEQFKVKMTQKKEVTLPFLFTP---FKLLSDSKQFNILRKAR 406 g.ldpvqlGfllSag..LiGmafGalffGplADriGHLGvsRkrvllwsi + + + ++S ++Li +a+ +l + Dr+ LGv v+++ + NP_036459. 407 SyIKHRKFDEVVSLCkeLIHLALKGLSYYHTYDRFF-LGVN---VVIGFV 452 llFsvfTllcalAtnvtqLlilRflAGlGlGGlmpnliaLvSEYaPkrfR +s +ll + + nli vS + NP_036459. 453 GWISYASLLIIKSHS--------------------NLIKGVS--KEVKKP 480 gtavglmfcGyaiGaavggflagwLiPafGWrslFyvGGiiPllLllllm + ++ + f+ aiG++v+ fl Li a W yv G ll l++ NP_036459. 481 SHLLPCSFV--AIGILVAFFL---LIQACPW--TYYVYG---LLPLPIWY 520 rfLPESidflvekGkrpekvrrivnaIapqlqaeaqsRFVlalpeqksaq +L E f+v + l+++ + NP_036459. 521 AVLRE---FQVIQ----------------------------DLVVSVLTY 539 ktkrsvvklLFqgktakiTvlLWllyfGmllvgvYfltnWlPskLmvelG + + +v L++ +++ ++L y ml +g + + W P +L++ + NP_036459. 540 P-LSHFVGYLLAFTLGIEVLVLSFFYRYMLTAGLTAFAAW-P-FLTRLWT 586 fslskaaivgalfnfGGviGsiifGw.LaDrlgprfvtalllLlgavfav + ++ +++ ++ +++ ++L+ + g++ + +l ++++ ++ NP_036459. 587 RAKMTSLSWTF-------FSLLLAVFpLMPVVGRK-PDISLVMGAGLLVL 628 lvgsstlfsp....tlll...llgaiaGlfvnGgqsglyalmaefYPtai l+++ ++s ++++ +++++ll+ ++ +++ +s++ ++++ ++ NP_036459. 629 LLSLCVVTSLmkrkDSFIkeeLLVHLLQVLST-VLSMYVVYSTQ--SSLL 675 RATGvGWaigiGRlGaiiGPilaGvLL<-* R G + i i+ + la +L+ NP_036459. 676 RKQGLPLMNQI-----ISWATLASSLV 697 TIGR00893: domain 1 of 1, from 386 to 724: score -241.7, E = 72 *->LvtvinYLDRanlSfAaptGlqeDLGlsaaqygyv.fsAFsigYvlg L t + L + + +++ + +y++ F l+ NP_036459. 386 LFTPFKLLS--------DS---KQFNILRKARSYIkHRKFDEVVSLC 421 qfPggllLDRiGHarktlavaiVlWgvftllqafaggFstvtayvslyiL ++ l+L ++ t+ ++ + + v+ ++++ + +y sl+i+ NP_036459. 422 KELIHLALKGLS-YYHTYDRFFLGVNVVIGFVGWI-------SYASLLII 463 RvLlGaAGLEAplfPgiikivasWFPakeRatavsifnsaqylggiiggP + l+ g k v P++ + + + +g NP_036459. 464 K-----S--HSNLIKGVSKEVKK--PSHL-----------LPCSFVAIGI 493 lvgwilvhfssmgmkGWqwvFiieGilgiilgvlwlkfikdkpqkakwlt lv++ l + w + G l + +w++++++ + + NP_036459. 494 LVAFFLLIQA------CPWTYYVYGLLPL---PIWYAVLREFQVIQDLVV 534 eeekyivvggllaeqddskgkgpsepKkyqikelLkdrrvwgl.algqfl ++ y ++ ++++ + v++l+++ +++ NP_036459. 535 SVLTYPLSHF-----------------VGYLLAFTLGIEVLVLsFFYRYM 567 vnillyffltW.fPtyLkqerglsileaGflaslPgivgfvGmvLgGilS ++++l+ f +W+f t L +++l+ f+++l++++ + m+ G+ + NP_036459. 568 LTAGLTAFAAWpFLTRLWTRAKMTSLSWTFFSLLLAVFPL--MPVVGRKP 615 DlllrrgarFWkslvfArktaiiaglvlsllmfatnslvnGmppwaalal D+ l g A +++++ l++++ + ++ ++ l NP_036459. 616 DISLVMG---------AGLLVLLL--SLCVVTSLMK-RKD-SFIKEELLV 652 vaLaffgaglLgailwaviSdvlpgniagltgGlinslGYnlggivgPiv L +++ +l + ++ + S++l ++ l + i+ + ++++v+P++ NP_036459. 653 HLLQVLSTVLSMYVVYSTQSSLLRKQGLPLMNQIISWAT-LASSLVVPLL 701 iGyiaattGsfagallvvaalaligalsvLllV<-* +++l +l++++s+ ll+ NP_036459. 702 ----------SSPVLFQRLFSILLSLMSTYLLL 724 TIGR00880: domain 1 of 1, from 599 to 726: score -44.1, E = 2.5 *->GllvagyAlgqli.....ysPlsglltdRfGRkpvllvglfifvlsq +ll+a + l++++++++++s++ g +l+++l+++v+ NP_036459. 599 SLLLAVFPLMPVVgrkpdISLVMG--------AGLLVLLLSLCVVTS 637 alfAlsNPHsnitvLiisRflqGfgaaaalvagaAliaDiyppeeersva ++ s+i + ++lq +++ ++ ++ ++ + + + ++ + NP_036459. 638 LMKRKD---SFIKEELLVHLLQVLSTVLSMYVVYSTQSSLLRKQ-GLPLM 683 lglmsagialgpilGPplGgvlanvkqalgWRapFlilaalalaafilla + ++s+++ ++ ++ P+l + + + + +++++ +++++ NP_036459. 684 NQIISWATLASSLVVPLLSSPVL-----FQR--------LFSILLSLMST 720 fllpET<-* ll T NP_036459. 721 YLLLST 726 TIGR00861: domain 1 of 1, from 590 to 741: score -142.1, E = 63 *->AEflGTfllVffGvGsvlgvnvaskiiDkmksLssaygavGggasvp + ++ ff ++ ++ ++ v+ NP_036459. 590 ---MTSLSWTFFSLLLAV------------------FPLMP----VV 611 gqflgiaLAfGLavatlvyavggkISGAHlNPAVTiAlllgrrfplirvp g ++i+L++G ++ +l + VT + + +f + NP_036459. 612 GRKPDISLVMGAGLLVLLLSLCV----------VTSLMKRKDSFIKEELL 651 vYiVAQliGAilGaallygltsgaitefegnlavagsvlsaGifatfPks v Q++ + +l+ ++ ++ + l++ G NP_036459. 652 VHLL-QVL-----STVLSMYVVYST---QSSLLRKQ-----G-------- 679 yvsagqaffvEfIgTaiLvlvilattdpdrnrvprggilaPLaIGllval + +++++ +++ Lv+ +l++ +++ +++ NP_036459. 680 -LPLMNQIISWATLASSLVVPLLSSP--VLFQR--------------LFS 712 ihlslgpyTGtgmNPARslGPalvagligwgnkaFtvghwkYhWvywvGP i lsl+ + +l ++ g+++ +++v NP_036459. 713 ILLSLMST-------------YLLLS-TGYEA-----------LFPLV-- 735 ivGailgalvY<-* l+ l NP_036459. 736 -----LSCLMF 741 TIGR00846: domain 1 of 1, from 471 to 749: score -246.9, E = 60 *->KyPtRllsnlqevllgswlni.LlifpVplaiilglvgwsqtvPVVi K +++ev + s+l + ++++ +i+ + +++ q+ NP_036459. 471 KG------VSKEVKKPSHLLPcSFVA---IGILVAFFLLIQAC---- 504 AvflLnllgiipLAavvsVfaTEeLAhrlGetiGGLLNalATfGnAVeLI + + g++pL + ++ f L NP_036459. 505 -PWTYYVYGLLPLPIWYA------------------VL--REFQVIQDLV 533 iSlmAlkAeGkvevVraSLlGSiLsNLlL..VlGlsLllGGikniRDsnG +S + + G +L+ +l+ +Vl ls++ + R NP_036459. 534 VSVLTYP--------LSHFVGYLLAFTLGieVLVLSFF-----Y-R---- 565 vGveQtFnlgaAqtnsaLLllAiilsLvlPaaltagkpheksdevqdsiL + l+a t++a +++ t + + ++ + NP_036459. 566 ------YMLTAGLTAFAAWPFL-----------TRLWTR-------AKMT 591 elSrgiaivmlilYvafLvfQLvTHrqLFepeeeadsdvddevheePtav +lS ++ +l+l a+ + ++ v ++P NP_036459. 592 SLSWTF--FSLLL---------------------AVFPLMPVVGRKP--D 616 lSplsaaiwLvgaTIvvallaeylVdtidsvveslglSvaFIGvI.iipI +S +a +Lv+ ll+ +V ++ +s+ ++ + +++++ NP_036459. 617 ISLVMGAGLLVL------LLSLCVVTSLMKRKDSFIKEELLVHLLqVLST 660 VGNAAEHvtAviaAlkNKlDiAlgvalGSaLQialf...VvPvv.vlvaw V+ ++ v+ ++Q++l++++ P+++ +++w NP_036459. 661 VL-------------------SMYVVY--STQSSLLrkqGLPLMnQIISW 689 a.lGipMdLnF.....gtpEtvaLvlsvflttitlqDGrSnyLeGavlLA a+l ++ + +++ + + + ls++ t +l++G + + + + NP_036459. 690 AtLASSLVVPLlsspvLFQRLFSILLSLMSTYLLLSTGYEALFPLVLSCL 739 lYiiialaff<-* +++ i + NP_036459. 740 MFVWINIEQE 749 TIGR00836: domain 1 of 1, from 452 to 756: score -334.3, E = 73 *->DtaWlLvaaaLVffMTqpGfalLYgGlvRs.KNvlNimmknlvdfav + W+ a++L++ + + G ++ K ++ ++v+ ++ NP_036459. 452 -VGWISYASLLIIKS-HSNLIK---GVSKEvKKPSHLLPCSFVAIGI 493 vIasllwvlf..G.Ys.laFGflsDddiepvngfiGngdqfgLkgfslgp + +++l++ ++++ +G ++p++ ++ L+ f ++ NP_036459. 494 L--VAFFLLIqaCpWTyYVYG----LLPLPIW-------YAVLREFQVIQ 530 gavaissagtlpdllfflFQlmFAaiaaaI..iSGAvAERmkFsayLlfs + + s+ t+p + f+ + l+F +++I+ + ++ F y+l + NP_036459. 531 D--LVVSVLTYPLSHFVGYLLAF---TLGIevLVLSF-----FYRYMLTA 570 vlwttlvYppvaHWvWggdgwaaagitGGwLyl................. +l + p ++ + W+ a t L+++ + + + + NP_036459. 571 GLTAFAAWPFLTRL-WT-----RAKMTS--LSWtffslllavfplmpvvg 612 .......klGalDFAGGtVVHivgGvaGLaaAlvLGPRiGrfpdDkGrpt ++++ + +Ga G+ V +++ L + L +R++ f+ ++ NP_036459. 613 rkpdislVMGA-----GLLVLLLS----LCVVTSLMKRKDSFI-----KE 648 airpHNlplvvLGtflLWFGWfGFNaGSaltIskaanglaGyGqWslaal +++ H l + + + +l+++ NP_036459. 649 ELLVH------------------------L--LQVLST-------VLSMY 665 aavnTnlAaAaGaLtwlliswlkdGKptvlgaisGilAGLVAITPgcgvV ++ T + k + l +++ i+++ + NP_036459. 666 VVYSTQSSL-----------LRK----QGLPLMNQIISW-A--------- 690 spwgAiiIGlvAGvlcylavskLkkklkiDDpLDafaVHGvgGiwGliat ++ +++++ l++ + ++ +++ +i+ NP_036459. 691 TLASSLVVPLLS------SPVLFQRLF-------------------SILL 715 GlFAapkvglsaGtagssrngGlllggngfkqLgvQiigilviiayafvv l ++ + ++y +++ NP_036459. 716 SLMST--------------------YLLL-------------STGYEALF 732 tfiilkiLkktiggLRVSeEeEklGLDlaeHgetgAY<-* +++ ++ +i E+E +++ + NP_036459. 733 PLVLSCLMFVWIN-----IEQE-------TLQQS-GV 756 TIGR00885: domain 1 of 1, from 486 to 775: score -260.3, E = 72 *->tsLFfLwGfindltdiLlPhL..qeaFhlsatdasl....iQfaFfg +s+ + ++iL++++ ++a ++ +l + +i a + NP_036459. 486 CSF--------VAIGILVAFFllIQACPWTYYVYGLlplpIWYAVLR 524 GY.fimalpAgllikkfSYkaGilLGLaLyAiGaaLFfPAasygsyylFL +++i l+ l +S++ G lL+++L + + L f NP_036459. 525 EFqVIQDLVVSVLTYPLSHFVGYLLAFTLGIEVLVLSF------------ 562 valFiLasGigiLETtaNPyvtaLGkektAaeRLnlaQsFNgLGalvgPv + + L++G++ +a P+ t L t + +++ +L + + + NP_036459. 563 FYRYMLTAGLTAF--AAWPFLTRL---WT-RAKMT------SLSWTFFSL 600 lgssLIlsnlksleqdslGnLiFdkLseeqiqaiksadlaiVqfPYllla l +++ l + + d+ + ++ + NP_036459. 601 LLAVFPLMPVVGRKPDIS--------------------------LVMGAG 624 vivlllaliiv..lnKlPnldvenvsdnskgeftkklsGFFrlfkhrhlr + vlll+l+ v++l K + + + ++ + + ls + l NP_036459. 625 LLVLLLSLCVVtsLMKRKD---SFIKEELLVHLLQVLS--------TVLS 663 lgvlaqFlYVGaeiacgsFlisYlveekssnksgqsakaevLAyYvsifw +v + ++ s l ++ +++ + + ++ NP_036459. 664 MYVVY---------STQSSLL------RKQGLPLMN------QIISWATL 692 vgfmvGRfigtflm.rrldaNEYKAsKaLaflAlisivLlllvifisGsS + v +++++++ rl+ +l+l s Lll++++ NP_036459. 693 ASSLVVPLLSSPVLfQRLFS---------ILLSLMSTYLLLSTGYEAL-- 731 VFYFvvgLfalfliglFmSimFPTIfslAlknLgkrltklGsGsflvmAI F + L++l ++ +n+ + +t + s NP_036459. 732 ---FPLVLSCLMFV---------------WINIEQ-ETLQQS-------- 754 vGGAiiPplqGfiaDqvgilqtpgiltaflvPLlc<-* G+ q+ + i +++ ++ NP_036459. 755 ----------GVCCKQKL----TSIQFSYNTDITQ 775 TIGR00909: domain 1 of 1, from 438 to 799: score -304.3, E = 9 *->LrReLGlFDltlLgiGaiiGtGiFvvtGiaAgkaGGPAviLsFvlAG +D Lg+ +iG +g + A+ L + NP_036459. 438 -------YDRFFLGVNVVIG---------FVGWIS-YASLL--IIKS 465 LtAlfiALvYaEl...aamlPvaGsvYtYayeAlGelvAFiiGWvliley l+ + + E ++++ lP + +A G lvAF NP_036459. 466 HSNLIKGVS-KEVkkpSHLLPCS-------FVAIGILVAFF--------- 498 gVAvAavAvgwsgYlqefLeGfvGldLPavLtakPgdggGtFtvfNlPAl + A w +Y+ ++L+ LP F v+ NP_036459. 499 ---LLIQACPWTYYVYGLLP------LPIWYAVL-----REFQVIQD--- 531 livlfltyilylGakeSgkvNsIlvv...LKvlavLlF....aalGaihf l+v+ lty l S +v+ +l ++ ++ vl++ F + +G f NP_036459. 532 LVVSVLTYPL------SHFVGYLLAFtlgIEVLVLSFFyrymLTAGLTAF 575 ksnPllvSNytpFmPmGfGgVlaatalvFfAFiGFeavstaAEEvKnPer ++ P l +t + ++ + +Ff+ +++ + v + NP_036459. 576 AAWPFLTRLWTRAK-------MTSLSWTFFSLL---LAVFPLMPVVGRKP 615 diPkaIilSLivvTllYvlvaavilGavRADVPfrqlagseaplslvkvs di + ++ ++v ll v ++ + + + e ++ l+ v NP_036459. 616 DISL-VMGAGLLVLLLSLCVVTSLMKRK------DSFIKEELLVHLLQVL 658 dlgqkigaliitaGAVisiasvml..atlYgtsRvl.FAmSRDGlLPksL ++ ++ V s+ s++l++ +l +++ A + l+ L NP_036459. 659 -------STVLSMYVVYSTQSSLLrkQGLPLMNQIIsWATLASSLVVPLL 701 SkvHpktkTPhvsilifsllaallAslvPlealaeltsigtLiaFalvnV S +P l++ l+++ll ++ + l t +L++ +l + NP_036459. 702 S-------SP---VLFQRLFSILLSLMST--YLLLSTGYEALFPLVLSCL 739 aviiLRrrrPdlqRAFkcPlvpVLpaLaAALLAVlllCi.yLllnlgegt + + + +lq +++ + L + +++ ++++ + + + NP_036459. 740 MFVWINIEQETLQ-QSGVCCKQKLTSIQ------FSYNTdITQFRQLYLD 782 tvi...flvwmllGsvfYfiY<-* +++ flv+ l++++f NP_036459. 783 DIRrafFLVFFLVTAFF---- 799 TIGR00852: domain 1 of 1, from 594 to 832: score -152.1, E = 4.3 *->GsaaFsfLPllfaigaakgfggnpylgaaLagilvhpvlnnamgvga +++ Fs L f +++g + + +l+++ + ++ ++l +++ NP_036459. 594 SWTFFSLLLAVFPLMPVVGRKPDISLVMGAGLLVLLLSLCVVTSLMK 640 qavggeIpVwnffgfeiakvgfnnsgltlgagIkTLytGvvgpiivgaia ++ + + + ++ v+ ++ + ++ NP_036459. 641 RKDS-----FIKEELLVHLLQ------------------VLSTVLSMYVV 667 lalheRfldkk.lPdvLgf.....FlgprfvvIIagfvailligpigrvw ++ + l+k +lP ++ + +++ +++v++++++v + r NP_036459. 668 YSTQSSLLRKQgLPLMNQIiswatLASSLVVPLLSSPV------LFQRLF 711 ppvQsgIsallswlvsaggalGgaifGflyrlLVpTGLHHifyaifiqli ++ ++s +++l + g+ a+f ++L ++ +++ i++ ++ NP_036459. 712 SI---LLSLMSTYLLLSTGY--EALFPLVLSCL-MF----VWINIEQETL 751 agetvigggqvipgdalan..vAQggaaLavlftagdakfksiglpaafs + ++v + ++ +++ n+++ Q f++ NP_036459. 752 QQSGVCCKQKLTSIQFSYNtdITQ---------------FRQ-------- 778 agLgitelAiYgvAlrerrpfvagliisalltafltgitepleflfLfga +Y +r+ + +v+ l+ ++ +t +++i+ + NP_036459. 779 ---------LYLDDIRRAFFLVFFLVTAFFGTGNIASIN----------S 809 PglyiihavlagliftvaigmgI<-* + l+++ ++l+ ++ + + ++ + NP_036459. 810 FDLASVYCFLTVFSPFMMGALMM 832 TIGR00790: domain 1 of 1, from 647 to 838: score -170.0, E = 45 *->KaalsllsllvlSilAGafialGaHASgLlvavvtggtaiegappgl K+ l l vlS + ++++ ++ + +++++ + NP_036459. 647 KEELLVHLLQVLSTVLSMYVVYS------TQSSLLRKQGLPLMNQ-I 686 vkLVgGavFpiGLilVViaGsdLFTGNtlfvtmAllrgkISwldllinWv ++ + +++ lVV L + +lf l++ S++ + ++ NP_036459. 687 ISWA-----TLASSLVVP----LLSSPVLFQ--RLFSILLSLMSTYLLLS 725 vsw..lGNLVGalfvAylisylggiltangAVEKNlwgvgslaiAehKvh + ++ l+ LV l+ ++++ + +t + ++gv + ++K+ NP_036459. 726 TGYeaLFPLV--LSCLMFVWINIEQETLQ------QSGV----CCKQKLT 763 gGAFIAAGKvv.ShTFvelfllGilCNwlVCLAvwlslsakdlagKffam + S+ + ++ +l ++d+ ff++ NP_036459. 764 --------SIQfSYNTDITQFR--------------QLYLDDIRRAFFLV 791 wfPifaFVAsGFEHsVANMflipiaifighfasPeFWqlvgsapenFadl +f ++aF++ G +ia ++ + NP_036459. 792 FFLVTAFFGTG-----------NIASINSFD-----------------LA 813 tvgqfivkNLIPvtLGNivGGavfvGliYwylylk<-* +v+ f + + + +++l+ w + + NP_036459. 814 SVYCFLT----------VFSPFMMGALMMWKILIP 838 TIGR00816: domain 1 of 1, from 558 to 841: score -177.4, E = 62 *->fpigWFAivLGTggl.al.aslyysqllpilkvlsdvLviLaialFv ++ ++F + T+gl+a+ a+ ++ l+ +k+ s L F+ NP_036459. 558 LVLSFFYRYMLTAGLtAFaAWPFLTRLWTRAKMTS-----LSWTFFS 599 lftsvwlaRlIrYpenvlAElkHpVlssFialipistmllgilfikwgrp l+++v+ + p + + + V+++ ++s ++ l + NP_036459. 600 LLLAVFPLM----PVVGRKPDISLVMGAGLLVLLLSLCVVTSLMKRKDSF 645 lalewmVWViRiLyaiGaivqLlfsvlvvfelFknesieiehthPGwYLP + +e L + +++ ++s +vv+ + ++ LP NP_036459. 646 IKEE-------LLVHLLQVLSTVLSMYVVYSTQSSLLRKQG-------LP 681 pValif..isaaalailpyetgvwleltvlfnyfGlGaGfFlyLsLeaVl i++ + a++++ p + vlf +F+ L+ NP_036459. 682 LMNQIIswATLASSLVVPLLS-----SPVLF------QRLFSILL----- 715 llRLrlhgllpsalrPTmfIlLaPigvgivAliniARGAvnhgevItvaa L + ll T + L P +++ ++ i + ++ NP_036459. 716 --SLMSTYLLL----STGYEALFPLVLSCLMFVWI---NIEQETLQQSGV 756 ikeeflGFVStilaiiLWGfGLwqllfalrSLllwYlkklklpFalgwWA l +i + + + + Yl F+l + NP_036459. 757 CCKQKL------TSIQF------SYNTDITQFRQLYLDDIRRAFFLVF-- 792 FiFPlaayvnStllvykgfdvkvfqyigvily..vflnffwaillirTvn F + a+ ++ + +++ f+ ++v + +vf+ f+ + l+ + NP_036459. 793 --FLVTAFFGTG-NIASIN---SFDLASVYCFltVFSPFMMGALMMWKIL 836 kllkG<-* + + NP_036459. 837 IPFVL 841 TIGR00900: domain 1 of 1, from 564 to 850: score -223.3, E = 97 *->FrlLlaaqliSllGsaitqVAlpLlAyvlagtgsasvlslaalagll +r l+a l++ +++ p+ ++++ a+++sl + +l NP_036459. 564 YRYMLTAGLTAFAAW-------PF---LTRLWTRAKMTSLSWTFFSL 600 Pyvvl..sPiaGvlvDRydRKkvmigaDliravlvavlpfvallgGVdvl ++v++ P++G +D i++v +a+l++++l NP_036459. 601 LLAVFplMPVVGRKPD-------------ISLVMGAGLLVLLLS------ 631 eiwmvyvvafIlaiaqaFFtPayqamlPdlvpeEkWqLtrAnslsqlvrs + vv ++ ++F +eE L++ + +++ v s NP_036459. 632 ----LCVVTSLMKRKDSF------------IKEE--LLVHLLQVLSTVLS 663 lfyRiVGPgiGGllyatlgikwailvdavgFliSalliv.svRiPekaas + + + + ++l ++ l++ + iS +++++s+ +P + + NP_036459. 664 MYV-VYS-----TQSSLLRKQGLPLMNQI---ISWATLAsSLVVPLLSS- 703 eieplseRKtSlkavlRdilEGlkfvlknkvLrtLlllallfnlvfapii ++l+ +++ ++Ll+l + + l++ + + NP_036459. 704 --PVLF----------------------QRLFSILLSLMSTYLLLSTGYE 729 vvlfPyvtsky.lnrtsvhvGwvlaaFglGaL.lGaLllgsiLrrllgry +lfP+v+s + ++ ++ ++ + +l + + +++ + NP_036459. 730 -ALFPLVLSCLmFVWINIEQETLQQSGVCCKQkLTSIQFSY----NTDIT 774 fkriaLitgAvlviglailvvgllpprnsgfllllvlafaiGvgvgl..i ++r + + + +++ ++ l+++ f+ G +++++ NP_036459. 775 QFRQLYLDD---------IRRAFFL-----VFFLVTAFFGTGNIASInsF 810 nvpigtllQrsvpaellGRVfglqfslssaAgPLglilaGpLadklG<-* ++++ + +++++ ++G +l++ ++ ++l+ ++++ NP_036459. 811 DLASVYCFLTVFSPFMMG-------ALMMWKILIPFVLVMCAFEAVQ 850 TIGR00785: domain 1 of 1, from 472 to 855: score -318.8, E = 41 *->PvPdglnkgAWlllAIfvaaiVg....wilEPlP..lpvtaLlalip +v ++ k +ll + fva++++ +++++ P + +v Ll p NP_036459. 472 GVSKEVKKPSHLLPCSFVAIGILvaffLLIQACPwtYYVYGLLP-LP 517 iiavliGvlsfdgkeLAdpafkfknaslsWg...LsGFAdptiwLffgaF i ++ + d + + + ls + + L +F ++ L+++ NP_036459. 518 IWYAVLREFQ----VIQDLVVSVLTYPLSHFvgyLLAFTLGIEVLVLS-- 561 iLAtAlektgLgkRIAykLvkkmGsttLglGyflvfletlLapm.wpSNT ++ + + gL + A ++ ++ ++ ++++ f+++lLa ++ + ++ NP_036459. 562 FFYRYMLTAGLTAFAAWPFLTRLWTRAKMTSLSWTFFSLLLAVFpLMPVV 611 AR.........aggilLPiiksllpllgskpgdksprkigkyLmLgiays R+++ + +ag +L +++ ++ l + + ++ i L+ +++ NP_036459. 612 GRkpdislvmgAGLLVLLLSLCVVTSLMKRK----DSFIKEELLVHLLQV 657 asigssgfltGsAPNaLA....asllskilgieiswgdWflagfLPlgii s+ s+ ++ s L +++++ l+++i isw + ++ NP_036459. 658 LSTVLSMYVVYSTQSSLLrkqgLPLMNQI----ISW------A----TLA 693 LLLlvplLlYvlfpPelkskdevdlwAkeeLeemGplslrEkvliallgi + L+vplL+ p ++ + ++ +ll++ NP_036459. 694 SSLVVPLLS---SP----VLFQ----------------RLFS---ILLSL 717 fllalllWiFggslginniAyFasvVALlavvlmlilgivtWkDiqknkv ++ +lll s+g AL+++vl ++ + W i + NP_036459. 718 MSTYLLL-----STGYE---------ALFPLVLSCLMFV--WINIEQE-- 749 aWntLvlfGGlitLaggLkksGfikWlseklvgiLgfeGlsptiavlvlv L++sG + ++++f+ + i+ + + NP_036459. 750 ----------------TLQQSGVC---CKQKLTSIQFSYNT-DITQFRQL 779 vlfyillyfFaSntAhtaalvPiffsvAsialhGvPlellaLalalSaSl l i + fF ++ lv++ff++++ia+ ++ + la + + + NP_036459. 780 YLDDIRRAFF-----LVFFLVTAFFGTGNIAS--INSFDLASVYCFLTVF 822 mGfltPyaTpPnaIvYGsGYvkikdmwrvGailgivglivlllvgtlww< + + G+ mw++ +++ +v + + t+ + NP_036459. 823 S-----------PFMMGAL-----MMWKILIPFVLVMCAFEAVQLTTQL 855 -* NP_036459. - - TIGR00792: domain 1 of 1, from 487 to 858: score -329.9, E = 44 *->KlsYGfGDfgnnfifaivstYLlf......FYTDvlGlsaaivGank +f ++g +v ++Ll++ + ++Y v Gl + + NP_036459. 487 ----SFVAIGI-----LVAFFLLIqacpwtYY--VYGLLPLPIW--- 519 liLITtlFLVaRilDAitDPimGlivDrTrnItRwGKFRPwlLiGaipfa V+R + +i D + + T + +F +lL a++++ NP_036459. 520 -------YAVLREFQVIQDLVVSVL---TY---PLSHFVGYLL--AFTLG 554 i.vlvLlFttpdfsatgnpigklvyayitYi..llglfYSfvniPYwSlv i+vlvL F +++ g + +a+ ++++l++ NP_036459. 555 IeVLVLSFFYRYMLTA----GLTAFAAWPFLtrLWT-------------- 586 PaiTldprEResLstfRrfgAtlGgllvavivlPlvsyfggisageddkl R+++++ + +++ + +v Pl+ +g + NP_036459. 587 ---------RAKMTSL-----SWTFFSLLLAVFPLMPVVGR-----KPDI 617 GwfmfalilaligvvlliicffgTkErvsvseipkksekklslkkifkal m a++l l +++l ++ k ++ + k+ ++l NP_036459. 618 SLVMGAGLLVL--LLSLCVVTSLMKRKD---SFIKE-----------ELL 651 fkNdqLliLclayLfyllafnikngvqvYYftYvLgdpelfsilgliafi + Ll ++ L +++ + ++++ + ++ ++ i+ + NP_036459. 652 VH---LLQVLSTVLSMYVVYSTQSSLL---------RKQGLPLMNQII-S 688 gagLigvllfPrlvkkfgrkrlfligillmvlGllilffvgkAsnlplil a+L++ l +P+l+ + rlf i ll++ + +l+ +g + + l NP_036459. 689 WATLASSLVVPLLSSPVLFQRLFSI--LLSLMSTYLLLSTG--YEALFPL 734 vliiiagfgqnf...............vtglvWalqvimvaDtVDYGEwK vl+++ ++ +n+++++ ++++ +++ t++++ +D+ ++ NP_036459. 735 VLSCLMFVWINIeqetlqqsgvcckqkLTSIQFSY----NTDITQFRQLY 780 tGvRaEglvySvrtFvrKlGqAlaGflvGliLgiiGYvaNaaQspitlng + + ++++ ++ ++ ++ +G i++i + +++ t+ + NP_036459. 781 LDD----IRRAFFLVFFLVTAFFG---TGNIASINSFDLASVYCFLTVFS 823 qltikilifivPavfllLaaiiiarfYkLtekkhaeIveeLekTlqk<-* + + +l+ + ++ ++L + ++ + Lt +L +k NP_036459. 824 PFMMGALMMWKILIPFVLVMCAFE-AVQLT--------TQLS---SK 858 TIGR00837: domain 1 of 1, from 617 to 868: score -307.2, E = 5.4 *->GGaliiAGTvIGAGMLAlPvstAGaWFiwslllLillWflMlhSGLl ++ v GAG lL+ll l + + L+ NP_036459. 617 ------ISLVMGAG------------------LLVLLLSLCVVTSLM 639 lLEvyltyparkgasfnTiakdlLGktgniiag.lsllFvLYiLtyAYIS ++ +sf i ++lL + +++++ ls+++v Y + NP_036459. 640 ----------KRKDSF--IKEELLVHLLQVLSTvLSMYVV-------YST 670 agGsILselisesfgsinmsaraivlivFtvlfgsfvwlsTsaVDritrv ++ + ++ ++ + i++ + a+ l+ + +l ++++ NP_036459. 671 QSSLLRKQGLPLMNQIISWATLASSLV-VPLLSSPVL------------- 706 LlfgkiiaFalvfsgLlphvkgdlLldaatvalSdtsylpyiLsalPvcl F +fs Ll+ +++ lLl+ t+ + + +p++Ls l NP_036459. 707 --------FQRLFSILLSLMSTYLLLS--TGYE---ALFPLVLSCL---- 739 tSFGFHGnVPSLvkYydgnvkkvkksIlIGsaiALvlYilWqlaTmGnlP + + ++ s ++ l+ NP_036459. 740 -----------MFVWINIEQETLQQS---------------GVCCKQKLT 763 reeFlpiiakGgnldgLveALqgvlkSsaie.....lalelFSnlAlasS + +F+ n d+ + + ++++ ++ ++l++F l++ NP_036459. 764 SIQFSY------NTDI------TQFRQLYLDdirraFFLVFF----LVTA 797 FLGVtLGLFDYlaDLFKfddskkGRlktgllTFlPPLvlaLfyPeGFlyA F+G++ +a + f d ++ + +l +F P F + NP_036459. 798 FFGTG-----NIASINSF-DLAS--VYCFLTVFSP-----------FMM- 827 igYAGalaatiwavIiPalLawkaRkkfpnaggyrVwGGnklillVllfG Gal+ w ++iP +L+ a + +++ + + + l l+Vl++ NP_036459. 828 ----GALMM--WKILIPFVLVMCA-FEAVQLT--TQLSSKSLFLIVLVIS 868 <-* NP_036459. - - TIGR00801: domain 1 of 1, from 559 to 878: score -302.0, E = 11 *->RppflrrqtlvlgLQHLlAMFgatVlVPlLvGlapGLqgLsaeqlqY ++f+ r l++gL+ +A++ P L+ l NP_036459. 559 VLSFFYRYMLTAGLT-AFAAW------PFLTRLW------------- 585 LvsiaLltsGigTLLQlfrtggqgtrYYVGiGlPsyLGsSFafvaVaigl t+ ++t + S +f + + + NP_036459. 586 -------------------TRAKMT------------SLSWTFFSLLLAV 604 pmiaigsgyCqlDgqGnrlGipaimggliatGlvytllallikk...... + + + g ++i+ +mg+ +++ l+ ++++ ++k++++ NP_036459. 605 FPLMPVVG--------RKPDISLVMGAGLLVLLLSLCVVTSLMKrkdsfi 646 ...lgtrwlrrlfPPvVtGpVVmlIGLsLipvAvkmaaGGeaakssnnGa +++l+ +l++l ++V Ls v + + + + + NP_036459. 647 keeLLVHLLQVL-------STV----LSMYVVYSTQSSLLRKQG--LP-- 681 LCPSAdAPrPltygslenllvafvVLaliillnrFakGfl..ksisILiG l n +++ ++La +++ + +++l +++ sIL+ NP_036459. 682 ---------------LMNQIISWATLASSLVVPLLSSPVLfqRLFSILLS 716 ivvGYllAlamGlVdfspvkeApwfslPkpftfGvdYapsFelpailtml + Yll +s eA + + + f + +++++ t+ NP_036459. 717 LMSTYLL--------LSTGYEALFPLVLSCLMF-----VWINIEQ-ETLQ 752 pVaivtlvEsiGdltAtadvtgrdlsgetydprLhrGvlaDGlatllagl + + + + +++++ ++ + ++ +y ++ r+++ l+ +l + NP_036459. 753 QSGVCCKQKLTSIQFSYNTDITQ--FRQLYLDDIRRAFF---LVFFLVTA 797 vGgfPnTtFaQNiGVialTrVaSryVivgaAv..iLialGfvPKiaAlit + g++n +aS + + a v +L +++ + +++Al NP_036459. 798 FFGTGN--------------IASINSFDLASVycFLTVFSPF-MMGALMM 832 sIPspVLGGasivmFGmIaasGiRiLirnkldfrrnlliiaaSvgLGlGv ++ i + ++L++ + NP_036459. 833 ------------------------------WK-------ILIPFVLVMCA 845 tgapdifgnfpPesdNrdLEGleAiellllsGialagivAilLNlI<-* a+ +++ +s l+l+ +++ + i A+ + + NP_036459. 846 FEAVQLTTQLSSKS------------LFLI-VLVISDIMALHFFFL 878 TIGR00850: domain 1 of 1, from 466 to 881: score -305.0, E = 84 *->MnkviasLEkklk......Pf.aeKIarnrYLrAIRDGFIlsMPlii +++i k +k++++ P ++++I+ i NP_036459. 466 HSNLIKGVSKEVKkpshllPCsFVAIG-------------------I 493 fGSiFLLi..........ayvPn.afgeell..aftwgkdleaklmepln ++FLLi+ + + + +P+++++ l++++ + + l +pl+ NP_036459. 494 LVAFFLLIqacpwtyyvyGLLPLpIWY-AVLreFQVIQDLVVSVLTYPLS 542 qlkGiGGnvyyytmGImaLfVaFgiAknLaesykvdalsaGqIslaafll G t+GI L+ +F+ + L+ a + l + NP_036459. 543 ---HFVGYLLAFTLGIEVLVLSFFYRYMLTAGLTAFAAWPFLTRLWTRAK 589 atpysvlilaagpakeggvlgasWfPvI....parymGtkGLftAiIiAl t s + + + +v + Pv++++++++++ ++GL++ + NP_036459. 590 MTSLSWTFFSLL----LAVFPL--MPVVgrkpDISLVMGAGLLVLLLSLC 633 vsvevYkfiVkrNvvIKLPesVPPaVsqSFkaLIPgfav....iivlwai v++ k ++ IK e+ +q+ + + +v ++++++l NP_036459. 634 VVTSLMK---RKDSFIK--EELLVHLLQVLSTVLSMYVVystqSSLLRKQ 678 rlaikatlgesfheiImvllsplLs..alDgyvGGilvivgavaLLWFcG +l + + + + + ++l plLs+++l ++ il+ + LL ++G NP_036459. 679 GLPLMNQIIS-WATLASSLVVPLLSspVLFQRLFSILLSLMSTYLLLSTG 727 iHGasIVepai.apImlsnmdaNiaalqaggsveaaLaaqhlphi..... ++ p++ m ++ +lq+ g q+l i+ + + NP_036459. 728 Y---EALFPLVlSCLMFVWINIEQETLQQSG----VCCKQKLTSIqfsyn 770 ..ltsgflDsf.....vyiGGsGATLvlplammlaaRSkqlKaiGr..la +++t+ + + ++ ++ ++ Lv l+ + +i +la NP_036459. 771 tdITQFRQLYLddirrAFF------LVFFLVTAFFG-TGNIASINSfdLA 813 vvPgiFniNEPIlFGaPIVlNPvLfIPFiLvPiVnViifkafvstGiink v ++ + P + Ga L+ iL+P V+V+ + +v + NP_036459. 814 SVYCFLTVFSPFMMGA-------LMMWKILIPFVLVMCAFEAV------Q 850 svgvavPWTtPgpigiflsTGfkvlsfVLallllvidvvIYyPFvkvyD< l T ++ +s+ L ++l++ d+ F+ v D NP_036459. 851 -----------------LTTQLSSKSLFL-IVLVISDIMALHFFFLVKD 881 -* NP_036459. - - TIGR00353: domain 1 of 1, from 490 to 885: score -427.8, E = 77 *->AfgvLvYsFaVnDFsVeYVAahSnsqLPvfyklAAvWGgHEGSLLLW A+g+Lv F+ P+ y + NP_036459. 490 AIGILVAFFLL------------IQACPWTYYV------------YG 512 vllLSlWsaafAlfsrkqprelvArvLailGlisvGflLFvLftSnPFvR +l L +W a f + ++lv vL NP_036459. 513 LLPLPIWYAVLREF--QVIQDLVVSVL----------------------- 537 iFPdfPiEGRDLNPmLQDvGLIFHPPLLYlGYVGfsVAfAfAlASLlrGk ++P L + +VG+ Af + + L NP_036459. 538 TYP------------LSH-------------FVGYLLAFTLGIEVLVL-- 560 lDsaiARimRpWtLaaWlfLTlGIVLGSWWAYYELGWGGWWFWDPVENAS s + R+m LT+G ++W NP_036459. 561 --SFFYRYM----------LTAGLTAFAAW-------------------P 579 lmPWLlGtALlHSLsvTekrGvFkaWTlLLAilAfsLsLLG.....TfiV ++ L A + SLs T +lLLA+ ++ + G++++ ++ NP_036459. 580 FLTRLWTRAKMTSLSWT-------FFSLLLAVFPLM-PVVGrkpdiSLVM 621 RSGiLVSVHAFAlDntRGlvlLalfvlviggSLaLyAlRaGssvrSaVnf G LV lL+ + +v+ + ++ + NP_036459. 622 GAGLLV--------------LLLSLCVVTSL------MK--------RKD 643 sllSResliLlnniLLvaallvVlLGTLyPlvhkqLGlGsiSvGaPyFNs s++ e l+ l+ +L ++ + V T l+ kq G P N+ NP_036459. 644 SFIKEELLVHLLQVLSTVLSMYVVYSTQSSLLRKQ--------GLPLMNQ 685 mflpimtpfalLLgigllVrwgrDrtllIRcglviivlstlvaGLllpyl + + L l+V l +++ l ++++L+ yl NP_036459. 686 IISWAT------LASSLVV-------PLLSSPVLFQRLFSILLSLMSTYL 722 LrnkvvvsavlglamavviavLAiyelavrlsrnesffvGvRkikrsqwG L + g + + + + + + + + ++ q G NP_036459. 723 LLST-------GYEALFPLVLSCLMFVWINIEQE----------TLQQSG 755 mllAHlGValtviGivfSqnfsvEidVrlkpGqsvtlgqYeFrFrqvsee + S fs d+ + + + F F + ++ NP_036459. 756 ---------VCCKQKLTSIQFSYNTDITQFRQLYLDDIRRAF-FLVFFLV 795 aGPNytgekAiidvtkdGkPeaeLipErRyYevrrmtMtEaaidGGltrD + tg A i ++ a+++ + +v M+ a + + + NP_036459. 796 TAFFGTGNIASINSFD----LASVYC---FLTVFSPFMMGALMMWKILIP 838 LYavlGEkLgkgewAfRLYykPfvRWiWaGGLlMalGaLLsvFdlRkR<- v+ + + + L k++ + +Mal + v d NP_036459. 839 FVLVMC-AFEAVQLTTQLSSKSLFLIVLVISDIMALHFFFLVKDYGSW 885 * NP_036459. - - TIGR00883: domain 1 of 1, from 665 to 905: score -302.0, E = 98 *->GnavEwFDFylYgfaAvlvfntfFfPsgdplvallatfATFAvGFla + +Y++ l+ + l++++ + AT+A ++ NP_036459. 665 --------YVVYSTQSSLLRKQGLP-----LMNQIISWATLASSLVV 698 RPlGgivFGhfGDRiGRKktLviTllmMGigTvlIGLLPsYatIGiwAPi P+ NP_036459. 699 ------------------------------------------------PL 700 L...LllaRliQGFslGGEwGGAalylvEsAppgKRGfygSfqqvgap.. L++++l Rl+ +++l+ ++++ + ++++ + NP_036459. 701 LsspVLFQRLF------------SILLS---------LMSTYLLLSTGye 729 ..vGllLAalvvlllsyllgdeaPlleWGWRIPFlvsavlvligLylRrn l+L+ l+++ +++ e+ NP_036459. 730 alFPLVLSCLMFVWINI----EQ--------------------------- 748 LeETpvFekaqekhktrtgkkripla.elltkhrkafllvlglviatttt ET ++ + k+k + i++ + ++++++ l ++ a ++ NP_036459. 749 --ETLQQSGVCCKQK----LTSIQFSyNTDITQFRQLYL-DDIRRAFFLV 791 fYlittYlptYltttlgvSEAGYAlGLGlsansallvlmlslilffvviP f l+t++ ++t + a++ +++l+ + + v+ P NP_036459. 792 FFLVTAF---FGTGN--------------IASINSFDLASVYCFLTVFSP 824 l.sGaLSDriGRRrvliiftvlaallavPllma..LldsgYspftlvffl + +GaL +++ +++ ++l+ ++ a +L+++ s+ +l++++ NP_036459. 825 FmMGAL---------MMWKILIPFVLVMCAFEAvqLTTQL-SSKSLFLIV 864 llglaliggmytGpmgsllpElFPtevRytGasLaYnlAgaigGGlAPyI l++ ++ ++ NP_036459. 865 LVISDIMALHFF-------------------------------------- 876 AaaLvaitgddlyaig.....yylaalAlisL<-* Lv+ +g+ + ig++ ++y++++ i+L NP_036459. 877 --FLVKDYGS-WLDIGtsishYVIVMSMTIFL 905 TIGR00800: domain 1 of 1, from 522 to 928: score -243.2, E = 60 *->NeDLkPvkeeeRtdWsflnyfslWlgaafniatwaigatllalGgLS +++ + +++ l + l ++++++ ++ +++++ NP_036459. 522 ---VLREFQVIQD----LVVSVLTYPLSHFVGYLLAFTLGIEV---- 557 wwqavlaiilGnllvgifvalnsiaGakyGlpFpvlsRaSFGiyGsllps vl++ + l++ ++a+ a++ + + Ra + ++s NP_036459. 558 ---LVLSFFYRYMLTAGLTAF-----AAWPFLTRLWTRAKMTSLSWTFFS 599 LlR.avmaigWfg....vqawvGglavallLdsifpgflhlgnpdtftkl Ll +++++ g+++++ +++G+ ++llL ++l ++ +d f NP_036459. 600 LLLaVFPLMPVVGrkpdISLVMGAGLLVLLLSLCVVTSLMKR-KDSFI-- 646 glttlelicFiifwvlvlvvlfffgykirhlfewlavv.....vpfaafg +e +++ ++vl++ + ++ ++++ +++ ++++ p+ + NP_036459. 647 ----KEELLVHLLQVLST------VLSMYVVYSTQSSLlrkqgLPLMNQI 686 mliwalskahGkgplfeltssgtlkgstgawsflsalslvigsfatlaln +++++l + ++pl+++++ +f + +s + +t l+ NP_036459. 687 ISWATLASSL-VVPLLSSPV-----------LFQRLFSILLSLMSTYLLL 724 apDFtRFakskkaaiwgiqllalpggfaltaffGilgasaasaayGepyW + ++ ++ + ++ +++ + G++ +++ + ++ NP_036459. 725 STGYEALFPL-VLSCLM--FVWINIEQETLQQSGVCCK---QKLTSIQFS 768 spvdila....rflgliyavlarAGvFligfcfvvatlSlivNisaNiyS +di + ++ +++ a++ + f +v a ++ ++Ni+S NP_036459. 769 YNTDITQfrqlYLDDIRRAFFLV-------FFLVTAFFG-----TGNIAS 806 a.gldiaallPkyikikrvvGslicaiiaLlicpWnly...ssssk.ftt ++++d+a + ++ + + +a++ + i+++ ++ ++++ ++tt NP_036459. 807 InSFDLASVYCFLTVFSP---FMMGALMMWKILIPFVLvmcAFEAVqLTT 853 fLssiGgfLspvaG..VmiADYFivRRrylhlttlysdsgkgeYypggnk Lss + fL + ++++m + F++ + y + ++ ++ ++y ++ NP_036459. 854 QLSSKSLFLIVLVIsdIMALHFFFLVKDYGSWLDIGTSI---SHYVIV-- 898 kGvnwravvAvicgsilapklpgfvgevgrnwdigvlig<-* ++++ + +g la l+ ++ + + ++++ NP_036459. 899 --MSMTIFLVFLNG--LAQLLTTKKLRLCG-----KPKS 928 // hmmpfam - search a single seq against HMM database HMMER 2.1.1 (Dec 1998) Copyright (C) 1992-1998 Washington University School of Medicine HMMER is freely distributed under the GNU General Public License (GPL). - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /data/patterns/tigrfam/tigrfam.hmm-f Sequence file: NP_036459.1.fa - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: NP_036459.1 phosphatidylinositol glycan, class N; [Homo sapiens]. Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- TIGR01058 parE_Gpos: topoisomerase IV, subunit B 3.8 1.6 1 TIGR01068 thioredoxin: thioredoxin 2.6 31 1 TIGR01119 lacB: galactose-6-phosphate isomerase, LacB -0.2 34 1 TIGR00698 TIGR00698: conserved hypothetical integral -0.9 60 1 TIGR00890 2A0111: Oxalate/Formate Antiporter -1.4 89 1 TIGR00147 TIGR00147: conserved protein of unknown fun -1.6 78 1 TIGR01117 mmdA_bact_arch: methylmalonyl-CoA decarboxy -1.9 81 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- TIGR01068 1/1 167 182 .. 86 101 .] 2.6 31 TIGR01119 1/1 288 321 .. 139 171 .] -0.2 34 TIGR01117 1/1 363 385 .. 491 513 .] -1.9 81 TIGR01058 1/1 555 567 .. 516 528 .. 3.8 1.6 TIGR00698 1/1 649 705 .. 276 335 .] -0.9 60 TIGR00890 1/1 707 746 .. 391 429 .] -1.4 89 TIGR00147 1/1 899 912 .. 1 14 [. -1.6 78 Alignments of top-scoring domains: TIGR01068: domain 1 of 1, from 167 to 182: score 2.6, E = 31 *->GalpKaaLkqlinknl<-* Ga++ ++L+ ++ +n+ NP_036459. 167 GAQDATKLDTWVFDNV 182 TIGR01119: domain 1 of 1, from 288 to 321: score -0.2, E = 34 *->AKikHlEthnakqADphFFdEF.LEKWdRGeYHD<-* A ik a+q D+ F E++LE W R + NP_036459. 288 AGIKYPQRVSAQQFDDAFLKEWrLENWKRLDVNQ 321 TIGR01117: domain 1 of 1, from 363 to 385: score -1.9, E = 81 *->sAleiLesKReklppKKHGniPL<-* +A++iLe+ ++k+ KK +P NP_036459. 363 NAVQILEQFKVKMTQKKEVTLPF 385 TIGR01058: domain 1 of 1, from 555 to 567: score 3.8, E = 1.6 *->IQvLLLTfFYRYM<-* I vL L fFYRYM NP_036459. 555 IEVLVLSFFYRYM 567 TIGR00698: domain 1 of 1, from 649 to 705: score -0.9, E = 60 *->kllvpldtfllatalaalglttnvgalkkaGlkPlllgllgflWlvg +llv l +l + ++t+ + l+k Gl Pl+ ++ W+ + NP_036459. 649 ELLVHLLQVLSTVLSMYVVYSTQSSLLRKQGL-PLMNQIIS--WATL 692 ggfllnylgsgll<-* + l+ l+s+ + NP_036459. 693 ASSLVVPLLSSPV 705 TIGR00890: domain 1 of 1, from 707 to 746: score -1.4, E = 89 *->FqSvAGifGGliaslvlteiGfkvtf.lvtaalallSlaL<-* Fq + +i+ +l ++++l + G +++f+lv +l+++ + NP_036459. 707 FQRLFSILLSLMSTYLLLSTGYEALFpLVLSCLMFVWINI 746 TIGR00147: domain 1 of 1, from 899 to 912: score -1.6, E = 78 *->mSMkkallIlNpta<-* mSM +l+ lN++a NP_036459. 899 MSMTIFLVFLNGLA 912 // SMART hmmpfam - search a single seq against HMM database HMMER 2.1.1 (Dec 1998) Copyright (C) 1992-1998 Washington University School of Medicine HMMER is freely distributed under the GNU General Public License (GPL). - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /data/patterns/iprscan/data/smart.HMMs Sequence file: NP_036459.1.fa - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: NP_036459.1 phosphatidylinositol glycan, class N; [Homo sapiens]. Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- [no hits above thresholds] Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- [no hits above thresholds] Alignments of top-scoring domains: [no hits above thresholds] // COG hmmpfam - search a single seq against HMM database HMMER 2.1.1 (Dec 1998) Copyright (C) 1992-1998 Washington University School of Medicine HMMER is freely distributed under the GNU General Public License (GPL). - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /data/patterns/cogs/cogs.hmm Sequence file: NP_036459.1.fa - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: NP_036459.1 phosphatidylinositol glycan, class N; [Homo sapiens]. Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- COG1524 100.1 4.4e-26 1 COG1988 -43.2 30 1 COG1585 -54.3 50 1 COG2456 -60.2 74 1 COG1266 -61.9 69 1 COG1987 -63.6 89 1 COG1950 -63.8 42 1 COG3152 -67.1 29 1 COG2510 -71.0 15 1 COG0558 -72.1 50 1 COG2076 -74.0 58 1 COG3136 -76.2 98 1 COG3090 -81.1 80 1 COG1277 -82.0 92 1 COG0730 -82.8 0.6 1 COG2111 -84.2 39 1 COG1994 -86.1 66 1 COG0705 -86.9 30 1 COG0697 -91.0 15 1 COG0839 -91.1 23 1 COG0842 -92.8 40 1 COG0755 -99.0 43 1 COG2245 -104.7 76 1 COG0679 -105.4 28 1 COG0586 -106.3 65 1 COG0762 -109.3 72 1 COG0392 -109.4 93 1 COG1280 -112.1 70 1 COG0658 -112.1 45 1 COG0575 -113.0 9.3 1 COG0619 -119.3 80 1 COG2095 -121.2 22 1 COG1682 -123.4 18 1 COG0670 -131.9 76 1 COG1183 -134.6 29 1 COG0559 -136.1 8.2 1 COG0310 -136.3 52 1 COG0344 -139.4 39 1 COG3307 -148.5 32 1 COG1296 -155.2 74 1 COG0628 -156.4 5.6 1 COG2860 -160.6 50 1 COG0531 -164.4 38 1 COG0472 -169.7 15 1 COG1108 -172.3 19 1 COG3366 -176.8 70 1 COG1346 -180.5 34 1 COG0861 -182.1 58 1 COG2889 -184.4 31 1 COG1175 -184.7 10 1 COG1275 -185.2 59 1 COG0555 -187.5 35 1 COG2244 -192.2 14 1 COG1177 -196.3 26 1 COG1079 -198.6 41 1 COG1968 -199.5 65 1 COG2981 -199.9 57 1 COG0475 -202.2 13 1 COG3368 -210.4 15 1 COG0581 -215.6 67 1 COG1174 -216.3 39 1 COG0573 -219.6 41 1 COG0341 -220.4 41 1 COG0609 -225.3 54 1 COG1055 -226.7 98 1 COG1906 -233.0 6 1 COG0385 -234.7 35 1 COG0591 -234.8 30 1 COG2855 -235.4 49 1 COG0672 -244.3 33 1 COG1263 -248.7 55 1 COG0772 -250.5 37 1 COG0534 -254.2 26 1 COG0306 -258.0 36 1 COG2899 -265.4 64 1 COG0387 -269.2 80 1 COG0651 -274.4 17 1 COG3379 -281.5 9.3 1 COG3069 -281.9 73 1 COG2814 -286.7 17 1 COG2064 -297.4 62 1 COG0168 -297.4 47 1 COG0814 -298.8 9.1 1 COG1455 -306.8 11 1 COG1301 -316.1 83 1 COG2610 -317.1 8.9 1 COG0201 -324.5 17 1 COG1178 -331.0 54 1 COG1271 -337.4 60 1 COG1007 -341.6 79 1 COG2233 -346.8 20 1 COG0004 -350.1 11 1 COG0733 -359.0 60 1 COG3202 -363.3 14 1 COG2211 -374.9 95 1 COG2851 -378.6 30 1 COG1593 -382.7 40 1 COG1955 -384.7 44 1 COG2252 -389.0 71 1 COG3135 -396.5 38 1 COG2704 -401.4 31 1 COG1138 -417.4 15 1 COG2056 -417.4 51 1 COG1113 -423.9 44 1 COG1620 -462.6 86 1 COG1292 -463.1 67 1 COG0843 -467.4 21 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- COG1524 1/1 2 381 .. 1 518 [] 100.1 4.4e-26 COG3379 1/1 30 407 .. 1 510 [] -281.5 9.3 COG2076 1/1 468 561 .. 1 108 [] -74.0 58 COG1682 1/1 336 576 .. 1 276 [] -123.4 18 COG2860 1/1 411 577 .. 1 225 [] -160.6 50 COG0762 1/1 414 588 .. 1 199 [] -109.3 72 COG3136 1/1 490 590 .. 1 113 [] -76.2 98 COG0310 1/1 450 592 .. 1 228 [] -136.3 52 COG1346 1/1 461 613 .. 1 230 [] -180.5 34 COG1950 1/1 494 614 .. 1 137 [] -63.8 42 COG2981 1/1 398 622 .. 1 289 [] -199.9 57 COG0679 1/1 346 644 .. 1 361 [] -105.4 28 COG1177 1/1 475 644 .. 1 286 [] -196.3 26 COG0705 1/1 467 647 .. 1 243 [] -86.9 30 COG1266 1/1 434 647 .. 1 279 [] -61.9 69 COG0586 1/1 455 650 .. 1 228 [] -106.3 65 COG0672 1/1 244 650 .. 1 512 [] -244.3 33 COG1988 1/1 478 650 .. 1 212 [] -43.2 30 COG0558 1/1 478 650 .. 1 207 [] -72.1 50 COG0341 1/1 336 651 .. 1 367 [] -220.4 41 COG2111 1/1 445 651 .. 1 253 [] -84.2 39 COG0575 1/1 428 661 .. 1 345 [] -113.0 9.3 COG2456 1/1 553 665 .. 1 128 [] -60.2 74 COG0306 1/1 428 675 .. 1 519 [] -258.0 36 COG1275 1/1 402 676 .. 1 348 [] -185.2 59 COG1183 1/1 447 678 .. 1 308 [] -134.6 29 COG2899 1/1 412 683 .. 1 371 [] -265.4 64 COG0559 1/1 403 690 .. 1 352 [] -136.1 8.2 COG2855 1/1 435 706 .. 1 372 [] -235.4 49 COG1277 1/1 419 711 .. 1 352 [] -82.0 92 COG2510 1/1 589 719 .. 1 145 [] -71.0 15 COG0658 1/1 308 720 .. 1 521 [] -112.1 45 COG1968 1/1 522 725 .. 1 285 [] -199.5 65 COG0472 1/1 420 727 .. 1 432 [] -169.7 15 COG0385 1/1 462 734 .. 1 395 [] -234.7 35 COG2095 1/1 539 737 .. 1 218 [] -121.2 22 COG1987 1/1 669 737 .. 1 89 [] -63.6 89 COG2610 1/1 481 740 .. 1 472 [] -317.1 8.9 COG1906 1/1 390 746 .. 1 419 [] -233.0 6 COG0733 1/1 436 749 .. 1 491 [] -359.0 60 COG0609 1/1 490 750 .. 1 346 [] -225.3 54 COG0581 1/1 529 751 .. 1 336 [] -215.6 67 COG0755 1/1 466 751 .. 1 354 [] -99.0 43 COG1007 1/1 422 752 .. 1 513 [] -341.6 79 COG1296 1/1 526 752 .. 1 257 [] -155.2 74 COG0842 1/1 424 753 .. 1 365 [] -92.8 40 COG1280 1/1 592 753 .. 1 214 [] -112.1 70 COG0555 1/1 586 754 .. 1 269 [] -187.5 35 COG1263 1/1 427 756 .. 1 462 [] -248.7 55 COG1175 1/1 535 757 .. 1 314 [] -184.7 10 COG1301 1/1 434 757 .. 1 452 [] -316.1 83 COG1955 1/1 296 759 .. 1 612 [] -384.7 44 COG3202 1/1 392 759 .. 1 523 [] -363.3 14 COG0004 1/1 506 762 .. 1 466 [] -350.1 11 COG1174 1/1 471 763 .. 1 361 [] -216.3 39 COG1455 1/1 455 768 .. 1 471 [] -306.8 11 COG0392 1/1 475 773 .. 1 355 [] -109.4 93 COG1292 1/1 409 795 .. 1 582 [] -463.1 67 COG0843 1/1 340 796 .. 1 629 [] -467.4 21 COG0619 1/1 523 805 .. 1 323 [] -119.3 80 COG1620 1/1 473 806 .. 1 601 [] -462.6 86 COG2889 1/1 483 814 .. 1 406 [] -184.4 31 COG0861 1/1 481 815 .. 1 333 [] -182.1 58 COG3135 1/1 410 816 .. 1 560 [] -396.5 38 COG1994 1/1 592 825 .. 1 282 [] -86.1 66 COG0591 1/1 438 829 .. 1 529 [] -234.8 30 COG2704 1/1 520 832 .. 1 469 [] -401.4 31 COG0168 1/1 412 856 .. 1 561 [] -297.4 47 COG1113 1/1 533 857 .. 1 481 [] -423.9 44 COG3152 1/1 773 857 .. 1 152 [] -67.1 29 COG1138 1/1 448 858 .. 1 706 [] -417.4 15 COG0772 1/1 523 862 .. 1 416 [] -250.5 37 COG0201 1/1 464 867 .. 1 540 [] -324.5 17 COG3366 1/1 610 868 .. 1 327 [] -176.8 70 COG2211 1/1 455 872 .. 1 577 [] -374.9 95 COG2056 1/1 620 875 .. 1 463 [] -417.4 51 COG0387 1/1 530 879 .. 1 468 [] -269.2 80 COG0814 1/1 293 879 .. 1 610 [] -298.8 9.1 COG0730 1/1 578 884 .. 1 287 [] -82.8 0.6 COG0534 1/1 520 892 .. 1 482 [] -254.2 26 COG2064 1/1 349 892 .. 1 643 [] -297.4 62 COG2245 1/1 744 894 .. 1 197 [] -104.7 76 COG0475 1/1 521 895 .. 1 427 [] -202.2 13 COG1079 1/1 519 895 .. 1 388 [] -198.6 41 COG1271 1/1 441 902 .. 1 529 [] -337.4 60 COG3069 1/1 595 907 .. 1 456 [] -281.9 73 COG0651 1/1 526 908 .. 1 534 [] -274.4 17 COG1585 1/1 778 911 .. 1 160 [] -54.3 50 COG1055 1/1 546 912 .. 1 466 [] -226.7 98 COG2244 1/1 471 915 .. 1 510 [] -192.2 14 COG2851 1/1 618 915 .. 1 473 [] -378.6 30 COG3307 1/1 532 916 .. 1 484 [] -148.5 32 COG1178 1/1 443 918 .. 1 615 [] -331.0 54 COG2252 1/1 635 918 .. 1 467 [] -389.0 71 COG1593 1/1 390 920 .. 1 638 [] -382.7 40 COG0697 1/1 590 920 .. 1 321 [] -91.0 15 COG1108 1/1 671 922 .. 1 292 [] -172.3 19 COG0670 1/1 679 922 .. 1 262 [] -131.9 76 COG3368 1/1 518 923 .. 1 525 [] -210.4 15 COG0573 1/1 658 925 .. 1 336 [] -219.6 41 COG2233 1/1 497 926 .. 1 509 [] -346.8 20 COG0344 1/1 759 926 .. 1 250 [] -139.4 39 COG0531 1/1 466 928 .. 1 537 [] -164.4 38 COG0628 1/1 584 929 .. 1 381 [] -156.4 5.6 COG0839 1/1 782 929 .. 1 192 [] -91.1 23 COG2814 1/1 584 929 .. 1 407 [] -286.7 17 COG3090 1/1 760 930 .. 1 217 [] -81.1 80 Alignments of top-scoring domains: COG1524: domain 1 of 1, from 2 to 381: score 100.1, E = 4.4e-26 *->llldlsskaeenriddtriKkfaegrkFllkLLvaivllillylnsi ll+ f+ g +l ++ + +si NP_036459. 2 LLF------------------FTLG-----------LLIHFVFFASI 19 vnkfllaglvidadpsqdtfritadpfkklvliviDGLradlidalkeeg +++++ ++lv+++ p +++ ++ + +lvl+v DGLrad ++ l+e g NP_036459. 20 FDIYFTSPLVHGMTPQFTPLPPP---ARRLVLFVADGLRADALYELDENG 66 llpkleelnpilrsggmniytlecitpSFPTlTlpnhktliTGlyPdehg + ++p++r m + + ++++++ PT+++p+h +li+G+y+d+++ NP_036459. 67 -----NSRAPFIRNIIMHEGSWGISHTRVPTESRPGHVALIAGFYEDVSA 111 ivsnvlyDpeedEeymklsgarvlfndldlkplvkidartalkdvplvqd + + ++++p +++++lfn+++++ + ++++ p++++ NP_036459. 112 VAKGWKENP---------VEFDSLFNESKYTWS-----WGSPDILPMFAK 147 elfdrgkdllkvaffpwlqsevfdpflkeslprgrDtvivatffyfdekq +++ + ++ + +e+f + ++ +++ ++f + +++ NP_036459. 148 GASGDHV----YTYSYDAKREDFGA--QDATKLDT------WVFDNVKDF 185 adhqldlksSFLkddysvlndglllrenedpdraYdlvllhfpniDhaGH h + n l +ne+ +++lh ++iD+ GH NP_036459. 186 FHHARN-------------NQSLFSKINEEKI----VFFLHLLGIDTNGH 218 kyGpdSeedfiYdsyrkavkevDsllsdLleslqkh.eldddtlviivsD ++p S++ y ++k+vD+ +++++ + + ++d +t +i++sD NP_036459. 219 AHRPSSRD------YKHNIKKVDDGVKEIVSMFNHFyGNDGKTTFIFTSD 262 HGqsqvkskVvmnEygqrsgieavSDgavvshgglrgVYvyFqPamsyse HG m++ g shg ++ NP_036459. 263 HG---------MTDWG--------------SHGA-------------GHP 276 keleslrflfgvlkaflredeeeYlakpvsgnliknldegfgvqhfkqqi e++++++++g++ +++ + a+ + ++++k+++ +++ ++ q+ NP_036459. 277 SETLTPLVTWGAGIKYPQRVS----AQQFDDAFLKEWRLENWKRLDVNQA 322 kiillnerlgdkfdifmpipkngvegenpdflgqlglhlfsenagilsli +i++l+ l++ +p p n+v+ d+l++ lf+ ++ NP_036459. 323 DIAPLMTSLIG-----VPFPLNSVGILPVDYLNNT--DLFKAESM----- 360 allgpkffgeegkvriignili<-* ++ e+ kv + ++ ++ NP_036459. 361 -FTNAVQILEQFKVKMTQKKEV 381 COG3379: domain 1 of 1, from 30 to 407: score -281.5, E = 9.3 *->mglldrLres..dvrKvvviGLDgvPpEsLirkfadkG.....VlPN g+ +++ +r++v+ Dg + + + G+++ + + N NP_036459. 30 HGMTPQFTPLppPARRLVLFVADGLRA-DALYELDENGnsrapFIRN 75 LkkLlkkgskGalkSgiPPITvamWpsLvTGknPGElGvYGFrhRkggsY + + gs+G+ + +P ++ + L++G Y NP_036459. 76 I--IMHEGSWGISHTRVPTESRPGHVALIAGF-----------------Y 106 telYvadSkkvketav.WDrLgveLGkrslVvgVPpTYPPkrikGvlVSg e a k ke v+ D L e k NP_036459. 107 -EDVSAVAKGWKENPVeFDSLFNE-SKYTW-------------------S 135 FlTPdiekayayPpElkdEIlksvgrdyvfdVkyhdEKYNDKdafiedlw ++Pdi + +a k++ v+ y d k + + + + da + d w NP_036459. 136 WGSPDILPMFA-----KGASGDHVY-TYSYDAK-RED-FGAQDATKLDTW 177 .........rllearfevvkyyldaKdGLWDlftfvv.igTDRVhHalW. ++ ++ ++ + + ++K ++f + g D Ha + NP_036459. 178 vfdnvkdffHHARNNQSLFSKINEEKI-----VFFLHlLGIDTNGHAHRp 222 ..kyyDeeHplYpGegnkYEnvipdyYsLVDkeIGelleai......ase ++++y +H + ++VD + e+ ++ +++ + NP_036459. 223 ssRDY--KH------N----------IKKVDDGVKEIVSMFnhfygnD-G 253 dttlvvVSDHGfksmkGeFalNqWLaeeGyLklkeeGSWKPkiLseGiRi +tt + SDHG + + GS + ++ NP_036459. 254 KTTFIFTSDHGMT--------------------DW-GSHGAG--HPS--- 277 AKKLradllakrvdwtrviawvwGgyysRlylNleGREprGGHSiTFGGi l v w+ i + + NP_036459. 278 ------ETLTPLVTWGAGIKYPQR-------------------------- 295 YvvkadeadsVldElsdelkkIrgPnGekvedrVyepeelYpgdrgKalP v a +d lk r +n ++ ++ +++ NP_036459. 296 --VSAQQFDDAF------LKEWRLENWKRLDVN-----------QA-DIA 325 DLmVyiDdlsfrlagtigsPldyLreNdsGPddgaHsfeGiflllvpsvk +Lm + f l P dyL + e f v ++ NP_036459. 326 PLMTSLIGVPFPLNSVGILPVDYLN------NTDLFKAESMFTNAVQILE 369 dvskgssvsIYDvA.PTiLdLygvqiplreddGrtlvklld<-* k + v P + + +++ ++++ + l k+ + NP_036459. 370 QF-KVKMTQKKEVTlPFLFTPFKLLSDSKQF--NILRKARS 407 COG2076: domain 1 of 1, from 468 to 561: score -74.0, E = 58 *->mmaWiyLllAilfEVvgaisLKyseGftklwpslltivgiilSFylL ++ + g++ K+ ++l+p ++++gi+++F+lL NP_036459. 468 NL------------IKGVS--KEVKKPSHLLPCSFVAIGILVAFFLL 500 slAl.....ktG.lPlGvAYAvWtGiGivgtvLvGvvlFgEslslikllg ++A++ + +G lPl + YAv + ++ +v+v+ + +ls + NP_036459. 501 IQACpwtyyVYGlLPLPIWYAVLREFQVIQDLVVSVLTY--PLSH----F 544 iaLIlaGvvgLKlgsrk<-* ++ +la ++g+ + + NP_036459. 545 VGYLLAFTLGIEVLVLS 561 COG1682: domain 1 of 1, from 336 to 576: score -123.4, E = 18 *->flalklledirsllryrrliltLvkreikqRYrrsvLGvlWsllnPf f+++ + + ++++l + + L+k+e ++f NP_036459. 336 FPLNSVGILPVDYLNNTD----LFKAE-----------------SMF 361 lmilvytliFgfllrsrlgvvalggldyviylfaGllpwfffseslsrga ++++ + F++ + + + +++lf+ p+ + s s NP_036459. 362 TNAVQILEQFKVKMT------Q-KKEVTLPFLFT---PFKLLSD--SKQF 399 gsfvananlikklnikPlsvlp...latilanlfnfligisviililliv +++ ++ ++ik++++ v ++l++++ ++++ + + ++ +++v NP_036459. 400 NILRKARSYIKHRKF-DEVVSLckeLIHLALKGLSYYHTY-DRFFLGVNV 447 fgvlpswqllllplallllvlfvfglg...........lflaslsvfgfR ++++w + +l++ ++ g++++ +++++ + + ++++ NP_036459. 448 VIGFVGWISYASLLIIKSHSNLIKGVSkevkkpshllpCSFVAIGIL--- 494 DigqilglltqvlFflsPIiypvsilqlPekvspllylNPllhiieivRa ++l++ + + + ++y + + lP+++ l ++ ++i ++v NP_036459. 495 ----VAFFLLIQACPWTYYVYGLLP--LPIWYAVLREF---QVIQDLVVS 535 illggdlpidlesflyillltllllllGllffrklekrfvdvL<-* +l++ + ++ ++l + l + +l l++++ + l +++ + NP_036459. 536 VLTYPLS--HFVGYLLAFTLGIEVLVLSFFYRYMLTAGLTAFA 576 COG2860: domain 1 of 1, from 411 to 577: score -160.6, E = 50 *->rndtllttetlamlLsvLyiIGitAFAmsGALlAgr..ekMDlFGVi ++ + + +l+++ AL++ + +D F NP_036459. 411 HRKFDEVVSLCKELIHL-------------ALKGLSyyHTYDRF--- 441 vLasVTAiGGGaiRDvLLGhyPlgALWvkhpeYliialvaavltvvvarr +L++ +v +G +g W+ + l+i+ + + l v + NP_036459. 442 FLGV----------NVVIG--FVG--WISY-ASLLIIKSHSNLIKGVSK- 475 vrlmrllrklflvlDAiGLavFaiiGAqvA..ldmghsplIvvvaGviTG ++++ l++ + F++iG +vA l +++ p v G + NP_036459. 476 --EVKKPSHLLPCS-------FVAIGILVAffLLIQACPWTYYVYGLL-- 514 VGGGIlRDlLarriPL.....VLrkRDELYAtaAiagglvylllaeslgl PL+ VLr+ + lv+ +l++ l NP_036459. 515 --------------PLpiwyaVLRE-------FQVIQDLVVSVLTY--PL 541 satvAllvtlfvglflRLlAiRfhWkLPtFrleeets<-* s++v+ l+ + +g + +l+ + L t l++ + NP_036459. 542 SHFVGYLLAFTLGIEVLVLSFFYRYML-TAGLTAFAA 577 COG0762: domain 1 of 1, from 414 to 588: score -109.3, E = 72 *->msslifiLstllsLYalvvlLRiwLqwvradfYNPfSqFivkvTePv + ++ l+ L + ++Y + +F v NP_036459. 414 FDEVVSLCKELIH-----------LALKGLSYYHTYDRFFLGVNV-- 447 LspLRRiipfvGtiDfsplvlaivLtilkrivlfgllvlsvsvfviilli +i fvG i ++l+ + + l v + + + + ++ + NP_036459. 448 ------VIGFVGWISYASLLIIKSHSNLIKGVSKEVKK-PSHLLPCSFVA 490 lsilslLssliniylwllliyall...SWvppgrnnKpieq..flaqlse ++il+ ++li w +y ll+ + W+ r++ ++ q+ ++++l++ NP_036459. 491 IGILVAFFLLIQACPWTYYVYGLLplpIWYAVLREF-QVIQdlVVSVLTY 539 PlLnPiRdklvPpiGgiDlSPRAllvavliLqFldvlvlevlrvfalqiL Pl+ ++ l++ + gi + + ++ + l+ ++ + ++a +L NP_036459. 540 PLSHFVG-YLLAFTLGIEVLV----LSFFYRYMLTAGLTA---FAAWPFL 581 pgllsil<-* + l+ ++ NP_036459. 582 TRLWTRA 588 COG3136: domain 1 of 1, from 490 to 590: score -76.2, E = 98 *->maaLvfKAlLGAlvVlLiAvLSKTknYYIAGLVPLFPTFALIAHYIV ++G lv + + + YY+ GL PL P Y V NP_036459. 490 --------AIGILVAFFLLIQACPWTYYVYGLLPL-PIW-----YAV 522 gke.RsledLrtTivFgmwSiIPYfvYLvAlYy........fserlrLea e + dL ++ + + + YL+A ++ + +f +r L+a NP_036459. 523 LREfQVIQDLVVSVL--TYPLSHFVGYLLAFTLgievlvlsFFYRYMLTA 570 aLvlAvlvWLVaAavLvvlWvrLHa<-* L A ++W L lW+r NP_036459. 571 GL-TAFAAW----PFLTRLWTRAKM 590 COG0310: domain 1 of 1, from 450 to 592: score -136.3, E = 52 *->MHIpdGyLPppwcavwyvvAipvIGiYg.lirikRlleerremiPLt G+ +++ +a +++ I + ++li+ + +++ NP_036459. 450 -----GFVGWISYA-----SLLIIKSHSnLIK----GVSKE------ 476 AvlAAaiFvlsslkiPsPtGssvHlvGnGLaavLlGsPyvaalaaaIVLl + ++Hl +a+ G ++ a Ll NP_036459. 477 -----------------VK-KPSHLLPCSFVAI--G------ILVAFFLL 500 iQaLllghGGlTtLGANvfsMGvvgpfvgYyvfRllrslglslavfiaaa iQa + +Yyv+ ll + + + + + NP_036459. 501 IQA-------------------CP---WTYYVYGLLPLP--IWYAVLREF 526 agIgdaaiyvgte.....vqLalafpstsCpygltgllasmarfhiivaa +I d+++ v t + ++ v+ laf+ g+++l+ s+ ++ ++a NP_036459. 527 QVIQDLVVSVLTYplshfVGYLLAFT-----LGIEVLVLSFFYRYMLTA- 570 ltevpltilegiltvgvrpdLfklkpelvkerlgVis<-* g+ + +++p+L++l + +r++ +s NP_036459. 571 ----------GLTAFAAWPFLTRL--W---TRAKMTS 592 COG1346: domain 1 of 1, from 461 to 613: score -180.5, E = 34 *->MsesiislfglfLTLavYllarkLykRvk..npllnPlLvatlvlia ++++++s l + ++k vk+++ ll +va+++l+a NP_036459. 461 LIIKSHS-----------NLIKGVSKEVKkpSHLLPCSFVAIGILVA 496 .lLlltgisYedYmagakwLtfLLgPAVVALAiPLYkQrrllkkyWkpIl +Ll+ + +Y g +L ++ ++l++ +++ NP_036459. 497 fFLLIQACPWTYYVYGLLPLPIW---------------YAVLRE--FQVI 529 vgvvvGsvv...AivsgvllAkaLgldpeliaSllPKSvTTPIAmevsrs +vv++++ + + + g+llA Lg++ l++S+ + NP_036459. 530 QDLVVSVLTyplSHFVGYLLAFTLGIE-VLVLSFFYR------------- 565 IGGiPalTAvfViltGllGailGpllLkvlgvrhpiArGlalGtssHAlG +lt+ l a + ++L++l NP_036459. 566 -----------YMLTAGLTAFAAWPFLTRL-------------------- 584 TAraiEegeeeGAaSSLaMvLcGvlTallaPl.lfaliaf<-* + + + SL+ ++ +++lla ++l +++++ NP_036459. 585 --------WTRAKMTSLSWTF---FSLLLAVFpLMPVVGR 613 COG1950: domain 1 of 1, from 494 to 614: score -63.8, E = 42 *->MvkfllrllVtalaLlvitqlvdGveissgdttLakvaiisvvAvvi v f l + +v +l+ + + +i + vv+ NP_036459. 494 LVAFFLLIQACPWTYYVYGLLPLPIWYAVLR---EFQVIQDL--VVS 535 GllNALIkPv......LliltlPlilLTLGLFllVvNAIvLwLtAaitdH +L P+++ + Ll +tl + L L F+ +LtA t NP_036459. 536 ----VLTYPLshfvgyLLAFTLGIEVLVLSFFYR------YMLTAGLT-A 574 ttHdglqidgFgWtAIwaAIlLsviswLLdklvsLLpldkrRvtRv<-* + + + A + +++s+LL + + L p +r NP_036459. 575 FAAWPFLTRLWT-RAKMTSLSWTFFSLLL-AVFPLMPVVGRK---- 614 COG2981: domain 1 of 1, from 398 to 622: score -199.9, E = 57 *->mVRIIAKSQSFIGGImvtiknmglrSGFtYflrGwKLirqSPGLRrF I+ K S+I r+ f + L + NP_036459. 398 QFNILRKARSYI----------KHRK----FDEVVSLCKE------- 423 VilPLllNilLlggLfwfllsqlddwiDiLmnylPDWLsfLsRRIPKVLP l+ + L g+ ++ + + +++++ W+s+ s NP_036459. 424 -----LIHLALKGLSYYHTYDRFFLGVNVVIGFV-GWISYAS-------- 459 YILPVLK....FIFyl.........lwpLivLlv.LvifgFtFStvanfI L ++K++++ I ++++ +++++l+p + ++ ++++F++ + NP_036459. 460 --LLIIKshsnLIKGVskevkkpshLLPCSFVAIgILVAFFLLIQ----- 502 aaPF....NGLLaEKvEtkLtGRedipdiglv.gLlkDvPRiLaREwrKL a P++ +GLL + ++ ++++ ++L+ v L + + NP_036459. 503 ACPWtyyvYGLLPLPIWYAVLR-----EFQVIqDLVVSV---LTYPLSHF 544 a.YlLPkaivL..flLsfiPavGqtlaPVlwfLFTaWMlAiQYcDYPfDN ++YlL ++++ + ++Lsf +t++ F aW Pf NP_036459. 545 VgYLLAFTLGIevLVLSFFYRYMLTAGL---TAFAAW---------PF-- 580 HKlsFreMlnlLrqk.rplsmgFGgltllftsIPLVNLvimPvAVcGATL l+ L ++ + +s+ +ll PL mPv NP_036459. 581 --------LTRLWTRaKMTSLSWTFFSLLLAVFPL-----MPV------- 610 mWVeeyrpehalvre<-* V +p+ +lv+ NP_036459. 611 --VGR-KPDISLVMG 622 COG0679: domain 1 of 1, from 346 to 644: score -105.4, E = 28 *->hislgamitivfevvlpilliillGyllkrfgilseedakiisrlvv +l+ + e+++ + il + +k + ++e + ++ + NP_036459. 346 VDYLNNTDLFKAESMFTNAVQILEQFKVKM--TQKKEVTLPFLFTPF 390 nvalPaliFssivtni..saelilsvlalilvalllivlliflalliarr ++++ + F+ + ++ + ++ +++ + + l l+ ++l l+++ ++ NP_036459. 391 KLLSDSKQFNILRKARsyIKHRKFDEV-VSLCKELIHLALKGLSYYHTYD 439 lfkldkatrggiilssvfpNtgflGiPillslpqGliFGeeeg....... +f ++g+ ++ ++ + +++ + i+ s + g +++ ++ NP_036459. 440 RF-----FLGVNVVIGFVGWISYASLLIIKSH-----SNLIKGvskevkk 479 ........ekglalavlfdllitilifslgvfflaggsfgktgesdssil +++ + + +++++ v+f+lli+ + ++ v+ l++ ++ + NP_036459. 480 pshllpcsFVAIGILVAFFLLIQACPWTYYVYGLLPLPIWYA-------V 522 lkllkskfPpllasetanllllgllllglpLnnvtlPeflldsldllkga l+ f++++ l++ l + l+ +++++l NP_036459. 523 LRE----FQVIQD------LVVSVLTYPLS-----------HFVGYLLAF 551 iqavplalislGlsLaplklkesvaglgaqvlikgiillasklkqlgSsi ++++ + L++ +++ agl +++ NP_036459. 552 --TLGIEVLV----LSFFYRYMLTAGL-------------TAFA------ 576 sLaplplvgfliafglglpplalgvlvLesairmmPsAalayvlArrygl ++p++ + +a+ + +l +++ L+ a ++ ++ + ++ NP_036459. 577 -AWPFLTRLWTRAK---MTSLSWTFFSLLLA-------VFPLMPVVGRKP 615 dpelvasiitlstlfslvtlplwiylillss<-* d lv ++ +l +l+sl +++ ++ +++s NP_036459. 616 DISLVMGAGLLVLLLSLCVVTSLM--KRKDS 644 COG1177: domain 1 of 1, from 475 to 644: score -196.3, E = 26 *->mssarsrwrlsflraflwlvlaFLYLPllilvlySFNtssklgtvwq + +++ + +l+ + +++ +++aF+ l ++ + + NP_036459. 475 KEVKKPSHLLPCSFVAIGILVAFF------LLIQACP----WTYYVY 511 GFTnpNLkWYaeLfqdedllsAaaNSLlIAvlsalvatvlGtLAAfALwR G+ p WYa+L++ + + + L + vl+ ++ +G L+Af L NP_036459. 512 GL-LPLPIWYAVLREFQVIQD-----LVVSVLTYPLSHFVGYLLAFTLGI 555 yrfrgknlvsgllllPlvvPdIvtGvsLLllFatwtaiglqLGWpqdrgf + lv + ++ +++ + L+ Fa a+ + + NP_036459. 556 -----EVLVLSFFYRYMLT-------AGLTAFA---AWPFLTR------L 584 ftiilaHitFclPfVyvvisaRLqgldlsLieAAaDLGAspwqtFfkitL +t +a++ l++ + ++++ + NP_036459. 585 WT-----------------RAKMTSLSW------------TFFSLLLAVF 605 PllaPgIlsGaLLAFtLSlDDFViTsFvsGVpTiGsetLPlqifsmirrG P l+P v+G NP_036459. 606 P-LMP----------------------VVG-------------------- 612 vvsPeiNAlatllllvlslllviasyllgvkrlekrrer<-* +P+i ++++ ++l++ll+ + + v+ l kr++ NP_036459. 613 R-KPDI---SLVMGAGLLVLLLSLCV---VTSLMKRKDS 644 COG0705: domain 1 of 1, from 467 to 647: score -86.9, E = 30 *->avliaplkfvqqrrtrptaplvtllliiltalvffisl.......fa li + + ++ l+++++ i ++ff++++ + + ++ NP_036459. 467 SNLIKGVSKEVKKPS---HLLPCSFVAIGILVAFFLLIqacpwtyYV 510 ldrvisllllsrqeqllllllpnpaladgqwwRvrvslitliTsmFLHag + + + ++++ +l +++++d ++T+++ H NP_036459. 511 YGLLPLPIWYA-------VLREFQVIQDLVVS--------VLTYPLSH-- 543 flHLlfNmlaLwiFGtalErilG.ssrflllyllsgllgglanlaqylls ++G l +lG ++ l +++ l + +l++++ NP_036459. 544 ------------FVGYLLAFTLGiEVLVLSFFYRYMLTA---GLTAFAAW 578 gpayganasfaphlGASGaiFGllGallllgpfarigllllliipvvlll + + l+ +++ ++ l ++++ lll NP_036459. 579 PFLT---------------------RLWTRAK-----MTSLSWTFFSLLL 602 alialvfisiwaelpgiswagVAhlAHLgGlivGlllgyllsrkkrrrry a++ l p is + +Gl+v lll +++ +r+ NP_036459. 603 AVFPLMPVVGRK--PDISLVM------GAGLLV-LLLSLCVVTSLMKRKD 643 llrs<-* +++ NP_036459. 644 SFIK 647 COG1266: domain 1 of 1, from 434 to 647: score -61.9, E = 69 *->lnslmrywpnllllaallfsavilvaalivlalfvltgvalallelw + +++ ++ +++ ++ ++ ++ +li+++ + l++ + + + NP_036459. 434 YYHTYDRFFLGVNVVIGFVGWISYASLLIIKSHSNLIKGVSKEVKKP 480 gvlgaillllalvlllllwllglsnaaaLwvavglirqrpfslllllnkg ++l + ++++ +l+++++l+ +++ + NP_036459. 481 SHLLPCSFVAIGILVAFFLLIQA---------------------CPWTYY 509 lswrllllgllvlfaamivlfavilllllllaplsalapitvvlfalavi + l l + + ++++ v+ + l+ +l pls ++ +l+a + NP_036459. 510 VYGLLPLPIWYAVLREFQVI--QDLVVSVLTYPLS---HFVGYLLAFTLG 554 lialllfwvflilllfllvalaEElfFRgivggllqgaLqqrlgpvpavi + +l+l+++ +R ++++a + + ++p NP_036459. 555 IE---------VLVLSFF--------YR-----YMLTAGLTAFAAWP--- 579 iasllFallHlalgalgvsismplwllvlaafvaGlvlgllylrtgsllv ++l++ + + + + +++++ +a + l + r +++ NP_036459. 580 FLTRLWTRAKMTSLSW----------TFFSLLLAVFPLMPVVGRKPDISL 619 pilaHgliNgalaallvlvfllplstalglll<-* +++a l +l ++v+ + + + + NP_036459. 620 VMGAGLLVL----LLSLCVVTSLMKRKDSFIK 647 COG0586: domain 1 of 1, from 455 to 650: score -106.3, E = 65 *->meeeltelleqh....................fgvwvylgylaiffl + ++ + ++ h++ ++ +++ +++++ + ++v + g+l+ ffl NP_036459. 455 ISYASLLIIKSHsnlikgvskevkkpshllpcSFV--AIGILVAFFL 499 ellelv.gppiPgevllvlaGvlagqGteelnlglailaaflGallGdli ++ + + + g + l+ ++ e++++ + +++l l + NP_036459. 500 LIQACPwTYYVYGLLPLPIWYAVLR----EFQVIQDLVVSVLTYPLSHFV 545 sYyiGRrfGrprLrllrkfgkkffikpkkldkaeelferyGllslfvgRF +Y++ +G l+ + ++++ l+ + f +++l+ + R NP_036459. 546 GYLLAFTLGIE---VLVLSFFYRYM----LTAGLTAFAAWPFLTRLWTR- 587 iPgvRtvipmvAGmskmplkrFllynalGallWaavlvllGYflGeviei +km + +++++l ++++ l G ++i NP_036459. 588 --------------AKMTSLSWTFFSLL------LAVFPLMPVVGRKPDI 617 vlnylstyliailllilvlillggwlvalWakaiylyrkkrekkklkkqa l ++++l+++l+ l ++ + +++k ++ NP_036459. 618 SLV-------MGAGLLVLLLSL------------CVVTSLMKRKDSFIKE 648 av<-* + NP_036459. 649 EL 650 COG0672: domain 1 of 1, from 244 to 650: score -244.3, E = 33 *->kerikevkDrdvdsaqqtfdtvkakmkkeearikkealasvsvadan + + D+ t d + a e l a NP_036459. 244 MFNHFYGNDGKT-TFIFTSDHGMTDWGSHGAGHPSETLTPLVTWGAG 289 vAm.islaainqdarklktellelarqLvdyteavLdkkfavyrsGdSdr + ++ +a d lk +le ++ L ++ ++ + + NP_036459. 290 IKYpQRVSAQQFDDAFLKEWRLENWKRLDVNQADIAPLMTSLIGVPFPLN 339 AydqsdkaylqiFEakgmeeaevavlssvlkaavdeglsvekeslayksa + + +yl ++ e+ +++ l k ++ k NP_036459. 340 SVGILPVDYLNNTDLFKAESMFT---------NAVQILEQFKVKMTQK-- 378 laagapekkkaleaelkdaklldaasqlkadsasnsasmlaaflivLREg k + l +++ kll ++q ++ + s+ f NP_036459. 379 -------KEVTLPFLFTPFKLLSDSKQFNILRKARSYIKHRKF------- 414 lEAiLvvavilayLKea.qteddtGrekklriivyaGallG..vvlslal ++++ Ke + +++ + y +lG +vv++++ NP_036459. 415 -------DEVVSLCKELiH----LALKGLSYYHTYDRFFLGvnVVIGFVG 453 GagvisvfgsiggdlftiekELfEGv............tsllAvvmLsym ++ +s++ + L+ Gv+++ +++++ + s++A ++L + NP_036459. 454 WISYASLLIIKS------HSNLIKGVskevkkpshllpCSFVAIGIL--V 495 glWMlrknarsvKweieiksskvlsggrgsdykkikklSrrwalaila.F +++l +++ w+ + ++l l+ NP_036459. 496 AFFLL---IQACPWTYY-----------------------VYGLLPLPiW 519 laVlREGlEtVlFlagiGisfqdqpls..ayplgvvaGlavavvlgvlly aVlRE ++ i qd s +ypl+ ++G ++a++lg+ + NP_036459. 520 YAVLRE-------FQVI----QDLVVSvlTYPLSHFVGYLLAFTLGIEVL 558 rlgkaGsvrlnLklFFyitsalLlliaaGLvgkGvheLqEageenglqdq +l+ FFy + + aGL++ +++ + NP_036459. 559 VLS-----------FFYR-----YMLTAGLTAFAAWPFLTR--------- 583 vldskaynlGdsydiskavwhessllpekdligiillgifGYy....esl ++ + ++ + ++ + +ll++f+ + + ++ NP_036459. 584 LWTR------------------AKMTSLSWTFFSLLLAVFPLMpvvgRKP 615 epgSvlsq.livwlvllilililiqrgyrgkepakrseq<-* ++ v+ ++l+v+l+ l ++ +l++r+ + + e NP_036459. 616 DISLVMGAgLLVLLLSLCVVTSLMKRKDS----FIKEEL 650 COG1988: domain 1 of 1, from 478 to 650: score -43.2, E = 30 *->mMtyetHvl.lgiafalfpliafLalvlslikdlihDvdedviplsl + + H+l+ +++ a+ l af+ l+ + p+ + NP_036459. 478 --KKPSHLLpCSFV-AIGILVAFFLLI--QA-----------CPWTY 508 lfagllgallilLlfpDidvlgsklgrs.lllylsklihrgfgHRslgFT + gll++ + + + + +++ ++ +l ++++ ++g + NP_036459. 509 YVYGLLPLP----I-WYAVLREFQVIQDlVVSVLTYPLSHFVGYL----- 548 HsLlslfaLsaillylllkDlpfvslwvalglksgsvldevtlGhlilda L +f+L + +l+l ++f+ +++gl + +++ l++ NP_036459. 549 --L--AFTLGIE--VLVL--SFFYRYMLTAGLTA-------FAAWPFLTR 583 ltpwgd...vrlllpsvgraripililvktgselgllvlmseaPiqllvf l+ ++ +++ +++ s ++a++p++++v +l+ +++++ +l+ NP_036459. 584 LWTRAKmtsLSWTFFSLLLAVFPLMPVVGRKPDISLVMGAGLL---VLLL 630 lpsfvlflrkmggrslvrif<-* + v++l+k ++ + NP_036459. 631 SLCVVTSLMKRKDSFIKEEL 650 COG0558: domain 1 of 1, from 478 to 650: score -72.1, E = 50 *->ntPNqlTllRlvlfLiplfallfllpgslgsf.vf.vvgnvvslrvl P +l + +++i++++++fll ++ + + + NP_036459. 478 KKPSHLLPCS--FVAIGILVAFFLLIQACPWTyYVyG---------- 512 llaalllfllaaltDwlDGylARkygqvtrfGafLDpvaDklldalvllg ll + ++ ++ R++ ++ d++v ++ NP_036459. 513 LLPLPIWYAVL-----------REFQ--------------VIQDLVVSVL 537 lvllgpvpgfnllwlvllilarevlslisslrlaaaeaggrceelavvaa + l+++ +l+++ l++ev +++s++ +++ ag l aa NP_036459. 538 TYPLSHFV----GYLLAFTLGIEV-LVLSFFYRYMLTAG-----LTAFAA 577 .....srlGklktlaqmiallteaeailllmilp............lvsv + ++ + ++k +++ + +++ lll+++p + +++++ +lv+ NP_036459. 578 wpfltRLWTRAKMTSLSWTFFS-----LLLAVFPlmpvvgrkpdisLVMG 622 llliaavltlisgiqyvlkfalkrlkkrr<-* + l++++l+l+++ + +k++ NP_036459. 623 AGLLVLLLSLCVVTSLMKR-KDSFIKEEL 650 COG0341: domain 1 of 1, from 336 to 651: score -220.4, E = 41 *->llldtgpIkgfaLtlavglf..salft.Alfmtdflftlder.tlgm + l I+ + lf+ +++ft+A+ + +++++++ ++ NP_036459. 336 FPLNSVGILPVDYLNNTDLFkaESMFTnAVQILEQFKVKMTQkKEVT 382 qlfkmklfvgikidFmkwrkvafivS....................glll f + ++ +k + i+ + ++ ++++ ++ + ++++ l NP_036459. 383 LPFLFTP-----FKLLSDSKQFNILRkarsyikhrkfdevvslckeLIHL 427 lisifsl......ffkGlnvfGiDFtG....Gtlielqfesasnyfeqsa ++ +s+ ++ ++ff G n i F+G + +l+ +++ +s NP_036459. 428 ALKGLSYyhtydrFFLGVN-VVIGFVGwisyASLLIIKS--------HSN 468 dieqvrealeaagkfgdvsvqsfGsngsdisirlkssd...........g i v ++ + + + s++ G+ ++++ + + + ++ NP_036459. 469 LIKGVSKEVKKPSHLLPCSFVAIGIL-----VAFFLLIqacpwtyyvygL 513 sdelvkrkvqeaLkksgdgevrsiefVGPtVGkeLreqgllAvlfALigI + + ++L++ ++v++ +V+ ++ L + ++f+L++ NP_036459. 514 LPLPIW---YAVLRE---FQVIQDLVVS-VLTYPLSHFVGYLLAFTLGIE 556 liYVglRFewrfaSlaAIlAlfHDviitlGfmSlfgFflkiEvdlatiAA +++++++++ + + + ++ l++ NP_036459. 557 VLVLSFFYRYMLT-AG--------LTAFAAWPFLTR-------------- 583 lLTvIGYSlNDTIviFDRiREnfrkkkkrkktlaeivNeSinqTLsRTin + +R + NP_036459. 584 --------------LWTRAKMTSL-------------------------- 593 TslTTllvvlaLllFGpvGgslkdFslaLlvGiivGTYSSifiAsplllw s T++ ++la + +pv g d+sl++ G++v ++ s +++ NP_036459. 594 -SWTFFSLLLAVFPLMPVVGRKPDISLVMGAGLLV------LLLSLCVVT 636 lgkkrsekklkpqak<-* +kr++ +k++ NP_036459. 637 SLMKRKDSFIKEELL 651 COG2111: domain 1 of 1, from 445 to 651: score -84.2, E = 39 *->lialiiivillaallvyvkslkitetailmlvskyyvensvedtggp + +i++v+++++ +++ +l+ ++ e+++++ + p NP_036459. 445 VNVVIGFVGWISYASLLII------KSHSNLIKGVSKEVKKPSHLLP 485 NvVtvIlvdyRgfDTLgEvsVlliAiiGvl.vya.ysvkllillesrrma + +f+ g ++ +++ i + y y++ +l + + ++ NP_036459. 486 C----------SFVAIGILVAFFLLIQACPwTYYvYGLLPLPIWYAVLRE 525 aalemslilktltrliapli.llfglylflhGhlaPGGGFqgGlvgAvaf + + +l++ +lt +++ ++++l+++ l + ++ + F + +++++++ NP_036459. 526 FQVIQDLVVSVLTYPLSHFVgYLLAFTLGIEVLV---LSFFYRYMLTAGL 572 iLlllafgkdpsvrrdflhtrfealealglllyvllGvisLllgllfltn ++ +l+t ++++ +l + sLll+++ l NP_036459. 573 TAFAAWPFLT------RLWT-RAKMTSLS------WTFFSLLLAVFPLMP 609 kavtnitsyyiygffglpgggNlVeaglapyrnfdvglkvvvglsaalil + g+ ++ ++ +++++l + v+ s + NP_036459. 610 ----------VVGRKPDISL-------VMGAGLLVLLLSLCVVTSLMKRK 642 lslirerke<-* s+i+e++ NP_036459. 643 DSFIKEELL 651 COG0575: domain 1 of 1, from 428 to 661: score -113.0, E = 9.3 *->mlkqrlitalilaplvgsfllllilrfalfallllalrlvalwemtr lk + + ++g + +++++++++a+ll+ + +++ +++ NP_036459. 428 ALKGLSYYHTYDRFFLGVNVVIGFVGWISYASLLI-IKSHS--NLIK 471 lvgvelrlkrvavillflllmlllvvallpavllgggdkilakfllwlpl +v++e + + + +f+++++l+ ++ll+ ++ + + ++ lpl NP_036459. 472 GVSKEVKKPSHLLPCSFVAIGILVAFFLLIQACPW-----TYYVYGLLPL 516 ilgilpldwgllflllvrtygkgltftgpvtglFacvvllgdtvgflfsa + ++ l + ++ +lv+ ++ + +++ NP_036459. 517 PIWYAVLREFQVIQDLVVSVLTYPL--S-------------------HFV 545 gkalgallltvlpilflllllrlfqiggyyltplrgallllllmigvwaa g+ l + l++ ++ l+++ ++l a+l+ ++ +w NP_036459. 546 GYLLAFTLGIEVLVLSFFYRYMLT------------AGLT---AFAAW-- 578 DigAYFiGklFGKtklaPkISPnKTvEGfigGlllavlvgslfglilgyp ++ +l+ + k+ +++ ++ lllav + ++++ NP_036459. 579 ---PFLT-RLWTRAKMTS-----LSWT--FFSLLLAVFPLMPVVG----- 612 yilfllqnlllallitnlffivllvvlsfyywWvsTLaLilfSlfsvlGD + ++++l+++ + l+vl l s++ NP_036459. 613 ------RKPDISLVMG-----AGLLVL----------------LLSLC-- 633 LfeSalKRdagvKDsgkllPGHGGiLDRiDSllftAppffafllileg<- + S +KR+ DS++ ++++ ++ NP_036459. 634 VVTSLMKRK--------------------DSFIKEELLVHLLQVLSTV 661 * NP_036459. - - COG2456: domain 1 of 1, from 553 to 665: score -60.2, E = 74 *->mLikilevklmyliQvigiiiilal...liysflrfkrsklslsdLl + i l +y + + ++a+ + l + r k +ls NP_036459. 553 LGIEVLVLSFFYRYMLTAGLTAFAAwpfLTRLWTRAKMTSLS----- 594 lWlalwvvvlifalnPekfsteIaeiLGlGRGLDaLlvitIvlaYyLLFr W ++ + +f l P +GR D lv++ +l+ +LL NP_036459. 595 -WTFFSLLLAVFPLMPV-----------VGRKPDISLVMGAGLL-VLLLS 631 LYldIDkiereITeLvreIAiRlkeeedkieRKP<-* L r + e+ + l NP_036459. 632 LCVVTSLMKRKDSFIKEELLVHLLQVLSTVLSMY 665 COG0306: domain 1 of 1, from 428 to 675: score -258.0, E = 36 *->mlwlfsyidvntmllllilalifglfmAfnIGANDvANamGTsVGSg l ++sy + + ++l++ +++ f++++ s++S NP_036459. 428 ALKGLSYY-HTYDRFFLGVNVVI-GFVGWI------------SYASL 460 aLtprqAviiaavfeflGAllaGgeVaeTIgsgivdpsllsdgpdvlleg + + + +i +v ++eV + +++++ s++ g +++ NP_036459. 461 LIIKSHSNLIKGV---------SKEVKKP-SHLLP-CSFVAIG----ILV 495 vlaaLlaAglWlliAtylGlPvSTtHsIVGaIiGaGlaaggltgglaigv ++ L+ A+ W ty+ V + + + +++ NP_036459. 496 AFFLLIQACPW----TYY----------VYGLLPLPIWYAV--------- 522 idwsvlgkIvlSWvlSPllGgllAyllfsllrklvleyneykedplksak + +++ +v+S +l y l +++ l+ NP_036459. 523 --LREF-QVIQDLVVS-----VLTYPLSHFVGYLL--------------- 549 ravpayielailvltvtikkglkasvlaysilltlgPiacaslivamlif NP_036459. - -------------------------------------------------- - kgvknkhlldvnnfliimigawlatflilkapkkpkrrkkdgkksverif f + + +++ NP_036459. 550 ------------------------AFTLGIEVL--VL---------SFFY 564 rvlqIitAclvAFaHGaNDvANAiGPiaavliglkpggivvNlNtYeIrT r+++ tA+l AF A P+ NP_036459. 565 RYML--TAGLTAF---------AAWPFLT--------------------- 582 rdaaheqylvsYnLSaqRqvRrylLCiSDtiKvksvadkrLklkadatst rL +a++t NP_036459. 583 ---------------------------------------RLWTRAKMT-- 591 ksyvpfwalilGaiglaiGtltgGwrRVieTVGkkItegLtpsrGFsAql s+ + +l a++ + VG+k + +s + NP_036459. 592 -SLSWTFFSLLLAVF----------P-LMPVVGRK-PD-------ISLVM 621 saAitVllAsllGlPVSTThvlVGAVlGvGlargnlvkwkviknIvlaWi +a+++Vll sl ++V + l +++ ik +l+ + NP_036459. 622 GAGLLVLLLSL---------CVV-----TSLMKRKDS---FIKEELLVHL 654 vTlPaaallSyllfllllaifg<-* + + + +lS +++ ++ ++ NP_036459. 655 LQVL-STVLSMYVVYSTQSSLL 675 COG1275: domain 1 of 1, from 402 to 676: score -185.2, E = 59 *->vntMrmskiknfpp.swFAivLGtggLAlawlsySsvlpalkaasiv r++ ik + + + ++ ++ LAl l +++ + NP_036459. 402 LRKARSY-IKHRKFdEVVSLCKELIHLALKG------LSYYHTYDRF 441 LtylataifflLLipwllkwil..ypnevl...aDLr...HPVlgSFypt ++ ++++i+f+ i ++ +i +++ n +++ ++++++++H+ +SF++ NP_036459. 442 FLGVNVVIGFVGWISYASLLIIksHSNLIKgvsKEVKkpsHLLPCSFVA- 490 ipiaamvvgaalihiypfaaapkvLwaiGvilqLlfSlllpyllfrgesf g+ ++++ ++ a+ w++ v ++L + + y r+ ++ NP_036459. 491 -------IGIL-VAFFLLIQAC--PWTYYVYGLLPL--PIWYAVLREFQV 528 elkhitPgWfiPPVglivisalslsllpHlsgvtqElhdlinlfgfGaGm ++ ++ + +P++ ++ l + l+ + +++ l+ aG+ NP_036459. 529 IQDLVVS-VLTYPLS-HFVGYLLAFTLG-IEVLVLSFFYRYMLT---AGL 572 flyLaLlpGvvlyRLilhepLPtaarPtlgInLAPigvgvvaylaiakhe +++a p l RL +++ + t ++ t + + ++v + +++ + NP_036459. 573 TAFAA-WP--FLTRLWTRA-KMTSLSWTFF----SLLLAVFPLMPVVGRK 614 saiqiaNikepalilafiLwGfGlwqllfailltlrylrkLklPfslswW ++i +l + + ++ l+l ++ NP_036459. 615 PDI-------------------SLVMGAGLLVLLLSLCV----------- 634 AFtFPlaayavstlhlassfgigvlstagfaLywflilawaillvkTlyv ++s+ + ++ + ++ l+ ++ +v+ yv NP_036459. 635 ---------VTSL--MKRK---DSFIKEELLVH----LLQVLSTVLSMYV 666 visgaaflsp<-* v+s++ +l NP_036459. 667 VYSTQSSLLR 676 COG1183: domain 1 of 1, from 447 to 678: score -134.6, E = 29 *->rriesiksikyqSldrsnvskeflmnglemkvrifriyllPnlfTal i + i y Sl+ + s l g ++v++ + llP++f a+ NP_036459. 447 VVIGFVGWISYASLL-IIKSHSNLIKGVSKEVKK-PSHLLPCSFVAI 491 nlfsGlyaIlsalsgtpsseltprwqyqlAailiflamifDGLDGrVARk ++ + ++ ++a t +++++++ l + ++++ R NP_036459. 492 GILVAFFLLIQACPWT--------YYVYGLLPLPIWYAVL--------RE 525 tnvlasSpFGaeLDSLaDvisFGVAPAllaYkaalgtfpg.tifGkfgll + v++ D++ +++ t+p++ ++G++ NP_036459. 526 FQVIQ------------DLV------------VSVLTYPLsHFVGYLLAF 551 vafl..yvlCgaLRTHLYLARFNvlvgkgpqvcdsryFiGlPiPaAAali + ++ +vl+ +R +++ + Gl + +AA+ NP_036459. 552 TLGIevLVLSFFYR------------YML--------TAGLTA-FAAWPF 580 vglvlldnsygiliatedtrilllvlalifgavLMvSnIrypsfkklsas ++ +++ ++ + l++ t++ ll +++ +LM r+p++ + NP_036459. 581 LTRLWTRAKMTSLSW---TFFSLL----LAVFPLMPVVGRKPDIS----L 619 ankstiEniSavsaLlvflaliaiilalvilqpsfv....llilalsyll +++ ++Llv+l + ++ +l+ ++sf++++ l+ l+ + NP_036459. 620 VMG---------AGLLVLLLSLCVVTSLMKRKDSFIkeelLVHLLQVLST 660 sgpivylrriikrkrkqs<-* +++ +++++++ ++ + NP_036459. 661 VLSMYVVYSTQSSLLRKQ 678 COG2899: domain 1 of 1, from 412 to 683: score -265.4, E = 64 *->MktfReFrGfSlLvTvvc..LalAawdGYaRGGHTllalanALfLlv R F v c++L a+ G + HT NP_036459. 412 ----RKFD----EVVSLCkeLIHLALKGLS-YYHTYD---------- 439 vLavLEVSLSFDNAViNAaiLkrMSefWqklFLtiGILIAVFGMRLVFPi + FL + I G + NP_036459. 440 -----------------------------RFFLGVNVVIGFVGWISYASL 460 vIVavtaGLglvevmklALenPAHGALEFADGSesYeklLtkahpaIAAF I+ + l++ + + P + lL ++aI NP_036459. 461 LIIKSHS--NLIKGVSKEVKKP--------------SHLLPCSFVAIGIL 494 GGmFLLmvFLdFlvdndrdlhWLkPiErpLAriGklDaVqaVivavaLll FLL+ + + L P+ A + +q +v+v+ NP_036459. 495 VAFFLLIQACPWTYY----VYGLLPLPIWYAVLREFQVIQDLVVSVLTYP 540 atkLfvapaeqfqdvLiAGLvGllvYLvvdaidrlFktdglG..EAtP.e + ++ L A +G+ v Lv r t+gl A P NP_036459. 541 LSHFVG--------YLLAFTLGIEV-LVLSFFYRYMLTAGLTafAAWPfL 581 vqvaqkAgkAGvAaFLYLEVLDAsFSfDGViGAFAiTkDvViIa.lGLGv + + A+ + + + L A F + V+G D+ +++++GL NP_036459. 582 TRLWTRAKMTSL-SWTFFSLLLAVFPLMPVVGR---KPDISLVMgAGL-L 626 iGAmFVRSiTvyLVrkgTLdeYvFLEHGAHYAIGaLAVI.mLlSidrrfh + + +T + rk+ + L H L V + lS+ NP_036459. 627 VLLLSLCVVTSLMKRKDSFIKEELLVH-------LLQVLsTVLSM----- 664 VPEvVTglvGvafIaaAlweSlrrnrrevls<-* ++ + +Sl r+ + l NP_036459. 665 ------------YVVYSTQSSLLRKQGLPLM 683 COG0559: domain 1 of 1, from 403 to 690: score -136.1, E = 8.2 *->rwailallyllalvpaavlmsdllqlllngltlgliyallALGLnlv r a+ ++ + + + ++ + + l+l gl++ y + LG+n+v NP_036459. 403 RKARSYIKHRKFDEVVSLCKELI-HLALKGLSYYHTYDRFFLGVNVV 448 yGltgiinlahgaFfmlGAYaaallllllgagg.gllpafalsplaalpl G g i+ Ya++l++ ++ + +g++ ++ p + lp NP_036459. 449 IGFVGWIS-----------YASLLIIKSHSNLIkGVSKEVK-KPSHLLPC 486 aflvaallgllierlvlrpllg.Lapliallalaigillvlqnlltqall +f++ ++l + +++ p + ++l+ l ++ ++++ ++++ NP_036459. 487 SFVAIGILVAFFLLIQACPWTYyVYGLLPLPIWYAVLREFQVI------- 529 lvsisvlllgglnvsvaapnglltpfaegggltlpgsrlslvllllalls + l vsv + + ++ g +l++++ NP_036459. 530 ---------QDLVVSVLT----YPLSHFVG--------------YLLAFT 552 lalllllallLlrskfGralrAvredeeaAralGinvervkllaFaisaa l + +l++ +++r ++ a+ NP_036459. 553 LGIEVLVLSFFYR-------------------------------YMLTAG 571 lAGlAGaLya......lylgtvnPtmgtfvisikafaavvLGGlGslpGa l ++A++ + ++ +++++++ ++t ++ ++ ++ v+G + + NP_036459. 572 LTAFAAWPFLtrlwtrAKMTSLSWTFFS-LLLAVFPLMPVVGRKPDISLV 620 vlGalliglaeells.lfpealll...................vykdvlv + ++ll+ l++ + ++ + + +++ +++ + + ++v ++++v NP_036459. 621 MGAGLLVLLLS---LcVVTSLMKRkdsfikeellvhllqvlstVLSMYVV 667 fgilllvlvllfrPqGllgleeraekperrkvr<-* + l+r qGl ++ ++ + NP_036459. 668 YS----TQSSLLRKQGLP------LMNQIISWA 690 COG2855: domain 1 of 1, from 435 to 706: score -235.4, E = 49 *->mhtMkettllkevarvrpfipGLLlsAliail....Alylgsiqsla ht +l v + + G + A ++i ++++ l g + ++ NP_036459. 435 YHTYDRFFLGVNVVIG---FVGWISYASLLIIkshsNLIKGVSKEVK 478 dTthlsALtLAIvlGivlGNTiYpqideevkaGVlFskqfLLRlGIvLYG hl + + + +Gi++ ++ i++ ++ LL+l I Y NP_036459. 479 KPSHLLPCSF-VAIGILVA--FFLLIQACPW---TYYVYGLLPLPI-WYA 521 frlTftdiadVGlegvlldaImlsstFllacfLGtRifKLDkqtSiLiGA + f+ i d + vl+ ++ + lla+ LG+ ++ L+ + + A NP_036459. 522 VLREFQVIQDLVVS-VLTYPLSHFVGYLLAFTLGIEVLVLSFFYRYMLTA 570 GSsICGAAAVlAtEPvvK..aeaekvsvAvatVViFGtvgiFLYPaifsl G A +A +++ +a s+ ++ L a f+l NP_036459. 571 -----GLTAFAAWPFLTRlwTRAKMTSLS--------WTFFSLLLAVFPL 607 asiwGLLffdpdtFGVyiGATvHEVAqVvaagemAKDmAgIepgaentAV + + pd + V +ag NP_036459. 608 MPVV---GRKPD------------ISLVMGAGL----------------- 625 IiKMiRVmMLAPFLLiLSallarnegsssgksGAskITIPWFAvlFlgVA L + L ++ l +r + +F+ NP_036459. 626 -------LVLLLSLCVVTSLMKRKD-------------------SFI--- 646 ifNSYLASKESildlLPkevVsllvtLdTfllamAMAALGLtthvsaikk KE +l V ll L T+l + t+ s ++k NP_036459. 647 --------KEELL-------VHLLQVLSTVLSMYVV----YSTQSSLLRK 677 aGlKPLllalvlflWLVvG.GffLtllisgil<-* Gl PL+ ++ W+ + + ++ ll s +l NP_036459. 678 QGL-PLMNQIIS--WATLAsSLVVPLLSSPVL 706 COG1277: domain 1 of 1, from 419 to 711: score -82.0, E = 92 *->nmmnsllaiarkelrsivrskrfyvllgllllFlllmllfifgytnq ++ l a k l+++ + rf + + ++ F+ ++++ +++++ NP_036459. 419 SLCKELIHLALKGLSYYHTYDRFFLGVNVVIGFVGWISYASLLIIKS 465 .......hpvqrksasklglfsdiaitpflsfflssysnlipitllglll +++ ++ + +k +s l s+ ai +++ffl + p+t+++ l NP_036459. 466 hsnlikgVSKEVKKPSHLLPCSFVAIGILVAFFLLIQA--CPWTYYVYGL 513 aillgadaisgEiek..GTiklLlSkPisRdeivlgKflgallvllilll l a+ +E++ + + +l++P+s ++ +l f+ ++ vl++ ++ NP_036459. 514 LPLPIWYAVLREFQViqDLVVSVLTYPLSHFVGYLLAFTLGIEVLVLSFF 563 itfillilfallffGtpdlaaylglfllslllsllytlillslGmliSsl ++l++++ + + ++ + + +sl ++++ +l+++ l+ ++ NP_036459. 564 YRYMLTAGLTAFAAWPFLTRLWTRAKMTSLSWTFFSLLLAVFP--LMPVV 611 iksqslslilgvglfllflfvipmiaaliaadsvsglppekfylnnasde + + +sl++g+gl +l+l+ + s ++ NP_036459. 612 GRKPDISLVMGAGLLVLLLSLCV---------VTSLMK------------ 640 iylinklnvqqrvltllleekvarniarsstspnyewqeskeyqfenkfl r +++ ee l NP_036459. 641 -----------RKDSFIKEE-----------------------------L 650 lnnvtqfssevllnsneslttgivgltplaeslslavanlviliilelll l q +s + s+ +++ ++l +++ ++++ + +++++ +l+ NP_036459. 651 LVHLLQVLS--TVLSMYVVYSTQSSLLRKQGLPLMN-QIISWATLASSLV 697 ffaiayllFnrrdl<-* ++++++ + r + NP_036459. 698 VPLLSSPVLFQRLF 711 COG2510: domain 1 of 1, from 589 to 719: score -71.0, E = 15 *->MmemdayifwALLaAfFagLapIFaKiGLkgvdPtfAttIRt..iVi m ++ + f+ LL A+F L p+ G k P+ + ++ +V NP_036459. 589 KMTSLSWTFFSLLLAVF-PLMPV---VGRK---PDISLVMGAglLVL 628 ailLliillllgkaqalssitpksllFlaLSGlagalsGWLlYFkAlklG + +L ++ l +++ + + +ll L l+++ls + ++ NP_036459. 629 LLSLCVVTSLMKRKDS---FIKEELLVHLLQVLSTVLS--M---YVVYST 670 kaSiVvPidkfS.vaLvvlLsvLfLgErlnlkqwIGalLIv.iGviLlSi + S+ + k + +++ s++ L + l + +L ++ iLlS+ NP_036459. 671 QSSL---LRKQGlPLMNQIISWATLASSLVVPLLSSPVLFQrLFSILLSL 717 sr<-* NP_036459. 718 MS 719 COG0658: domain 1 of 1, from 308 to 720: score -112.1, E = 45 *->mlarllltaasllivralarllrrfwalllfilvLllliillgflnl ++++ ++ ++ +a++ ++ +l+ ++ +L+ +il + NP_036459. 308 EWRLENWKRLDV----NQADIAPLMTSLIGVPFPLNSVGILPVDYLN 350 illwfalallflaalllgvllpvlllqqllgaGrtllynqkreafvavpw + f + +f a+ ++l q+++ + qk e +++ + NP_036459. 351 NTDLFKAESMFTNAV--------QILEQFKV-----KMTQKKEVTLPF-L 386 vlllqiaqlvflttlllpldqkrvllagrgqaleeeldgvtvvgadcsli ++ + ++ + + ++l+ ++r + + + v c + NP_036459. 387 FTPFKLLSDSKQFNILR---KARSYIK---------HRKFDEVVSLCKEL 424 gelkagrhlvnpagfdyeqilkiqriraflsvknkqsictsertqflskv l + +++ +++ fl + + + v NP_036459. 425 IHLAL----------KGLSYYHTYDRF-FL-----------GVNVVIGFV 452 dkersralglqflllapsqgglllAlilgdgselsnelrqafqrlGlaHL + s a+ l + ++ ++s+e++ + HL NP_036459. 453 G-WISYASLLIIKSH------------SNLIKGVSKEVKKPS------HL 483 laiSGlHvgllmasflflaelfyapllqrllprltarprylagllglllL l S +v+ ++ +l ++ ++ a p+ +++ ++l l NP_036459. 484 LPCS--FVA--------IG------ILVAFFLLIQACPWTYYVYGLLPLP 517 lfYallvGfspSvlRaflmtlllllgilffgrlsllnvlllvaillllff Ya l f + ++ ++++l +++f + l+++l++ +++l++f NP_036459. 518 IWYAVLREF-QVIQDLVVSVL--TYPLSHFVGYLLAFTLGIEVLVLSFFY 564 PhallsvgFiLSflatlgyilllssklkrelllrvlaallasllafllla +++l + l ++ ++ ++++l ++a+ +++l+ NP_036459. 565 RYMLT------AGLTAFA-AWPFLTRLW------TRAK------MTSLSW 595 qlitlplllslnallvllnlpanplsalplfglllllgllafipllg... +++l l+++ ++ +v + +s++ gll+ll +l ++ +l +++ NP_036459. 596 TFFSLLLAVFPLMPVVGRKPD---ISLVMGAGLLVLLLSLCVVTSLMkrk 642 w.lllsalgpfllrlldlllewllkvatflapvplpawilalllapplll +++ + l++ ll l+ +l++++ +t+++ ++++ +l+ ++ ++l NP_036459. 643 DsFIKEELLVHLLQVLSTVLSMYVVYSTQSSLLRKQGLPLMNQIISWATL 692 Lltpftvillllgvlsallallikipal<-* ++++ +l+ + +l+ +l +++++ NP_036459. 693 ASSLVVPLLSSPVLFQRLFSILLSLMST 720 COG1968: domain 1 of 1, from 522 to 725: score -199.5, E = 65 *->mmdlmslfqAliLGiveGlTEFLPISSTGHLilvshlLgfiwedelg + ++++q+l+ + lT +L sh+ g NP_036459. 522 VLREFQVIQDLVVSV---LTYPL-----------SHFVG----Y--L 548 ksFeivIQlGsiLAVvlyFrkdilrllkgfikyrltkreeskdfvlgliy ++F+ I+ +L +++r ++ l++f ++ r ++ +++ NP_036459. 549 LAFTLGIE---VLVLSFFYRYMLTAGLTAFAAWPFLTR-----LWTRAKM 590 iilatIPavvlGlLfkdliksyLfnslwvVa....iaLIvgGilLllaEk l +f l ++ +vV ++++i L+ g+ lL l+ + NP_036459. 591 TSLSWT-------FFSLLLAV-FPL-MPVVGrkpdISLVMGAGLLVLLLS 631 lsekkdrrtedvedltlkdAliiGlAQcLAlifPGiSRSGaTIsgGlllG l+ + + ++d k+ l++ l Q+L + NP_036459. 632 LC-VVTS-LMKRKDSFIKEELLVHLLQVLSTV------------------ 661 lnReaAaeFSFLLaIPtmlGA.gllaikDllksgell.ntsedlppliiG L++ ++ ++++l l k g++l n + ++ l NP_036459. 662 ------------LSMYVVYSTqSSL----LRKQGLPLmNQIISWATL--- 692 FItAFvvallaIkwLLkfikrhslipFaiYRiilGililallli<-* + vv ll+ +L++ + + i+l+++ +lll+ NP_036459. 693 -ASSLVVPLLSSPVLFQRLFS----------ILLSLMSTYLLLS 725 COG0472: domain 1 of 1, from 420 to 727: score -169.7, E = 15 *->MLlmLa..llpalsslnlfsYltafrallalliafllsllltpifip + +L++ l++ls++ ++ ++++++ + ++ ++ + NP_036459. 420 LCKELIhlALKGLSYYHTYDRFFLGVNV----VIGFVGWISYASLLI 462 flrklaikigqdirkdgpksHkshKagTPtmGGlaIllsflivlslllwa + +++ i + + +sH+ + ++ ++ i+++++l++ NP_036459. 463 IKSHSNL-IKGVSKEVKKPSHL-LPC-------SFVAIG--ILVAFFLLI 501 glnsganpyevevwlvLlvllgfgliGflDDlfklsrKnnkGLsakiKll + + p+ + ++ +ll++ + + f++ + NP_036459. 502 QAC----PW----TYYVYGLLPLPIWYAVLREFQVI-------Q------ 530 lqfiaAvlllilllkfdgslltqlyiPFfkspsfdlgtllylvlavfalV +++vl+ + l +f+g y+ ++f lg + lvl+ f+ NP_036459. 531 -DLVVSVLT-YPLSHFVG------YL-----LAFTLG-IEVLVLSFFYRY 566 gssNAvNltDGLDGLAaGlsviaalalaliaylsgnvnfAqYLlipyipd + L aGl+++aa ++ ++ NP_036459. 567 M-------------LTAGLTAFAAWPFLTRLWTRA--------------K 589 agelailclalaGAcLGFL.wfNfyPGkAkvFMGDtGSlaLGavlgalav ++ l + ++ l+ A+++ +++ + P D ++L + g l++ NP_036459. 590 MTSLSWTFFSLLLAVFPLMpVVGRKP--------D---ISLVMGAGLLVL 628 llkl.klq.ei....llli.mggvfvietlsvilqvlsrklrkdptigkr ll+l ++++ ++++++++ + ++v ++ +ls++l+++++ + + NP_036459. 629 LLSLcVVTsLMkrkdSFIKeELLVHLLQVLSTVLSMYVVYST-----QSS 673 ifkmaplHhHfelkgwglkftlrqflifiilcaigiLi.slslrllreak +++ l ++ ++ w +L++sl +ll+ + NP_036459. 674 LLRKQGLPLMNQIISWA------------------TLAsSLVVPLLSSPV 705 vvvrfWiislilaliglatlllaavgvllavifaflrfviwlklrl<-* + r ++s++l l++ ++ l+ + NP_036459. 706 LFQR--LFSILLSLMSTYL----------------------LLSTG 727 COG0385: domain 1 of 1, from 462 to 734: score -234.7, E = 35 *->ysliRmnilrkisrFlsktFtlwliilvllAfffPdffttlgpfeGQ n + +s ++k+ l+ ++v+++++ + f++ NP_036459. 462 IIKSHSNLIKGVSKEVKKPSHLLPCSFVAIGILVAFFLLIQ------ 502 YslipilLglImFgmGLtLtpeDfrevlrhPravligliaqfvimPl... ++p+ + +L p + ++++ ++v+ l+++ + Pl++ NP_036459. 503 --ACPWTYYV------YGLLPLPIWYAVLREFQVIQDLVVSVLTYPLshf 544 lafllskllkanNDPKldPelavGliLvgacPgGtaSnnvmTyLakGNVa +++ll++ l G+ +v ++ ++ NP_036459. 545 VGYLLAFTL------------------------GIEV-LVLSFFYR---- 565 LsVavtsvsTLLsplltPLlvnLftaYlaGdNPATgeglpvdflgmvkqi ++ L + P+l++L + + ++ + ++ NP_036459. 566 ----YMLTAGLTAFAAWPFLTRL----WTR------AKMTSLSWT-FFSL 600 llmVlvPiaLGmlvqNCFrkflpkvveklkkvLplvSvlsillIIaavfs ll V+ P+ m v + p++ ++ + L vl+++l +++++ NP_036459. 601 LLAVF-PL---MPV----VGRKPDISLVMGAGLL---VLLLSLCVVTSLM 639 aaaengashlvesglliflvVllhnllGllLGLSYLCARPWFILKLFPHE + + + ll+ l +l +l++ ++ NP_036459. 640 KRKDS----FIKEELLVHLLQVLSTVLSMYVV------------------ 667 PIEGKSTRLYRYlta..kllgLdyskrkaItIevGGPmqNsgLgaALAta Y+t +++l++ +++ I ++ ++L+ +L + NP_036459. 668 -----------YSTQssLLRKQGLPLMNQI-------ISWATLASSLVVP 699 qhffptshlplmAvPlaIfsvwqnltaavLasLlKryirRtaqataaqss ++ +++ ++q l + +L+ ++ + +t+ ++ NP_036459. 700 -LLS-----SPV--------LFQRLFSILLS----LMSTYLLLSTGYEAL 731 aad<-* + NP_036459. 732 FPL 734 COG2095: domain 1 of 1, from 539 to 737: score -121.2, E = 22 *->mdmmemlsfilsafllLfaiidPfGnlPvFlsLtenlsaeeRk.rva ++ + + ++l ++l++ +++ +f ++++ + + a +r+ NP_036459. 539 YPLSHFVGYLLAFTLGIEVLVLSFFYRYMLTAGLTAFAAWPFLtRLW 585 lrAsliAlliLlvFllfGeliLkdlFGI....sidafriAGGilLfliAi rA +++l ++ F + +++ l+ + ++++ ++ +++G+l++l ++ NP_036459. 586 TRAKMTSL--SWTFFSLLLAVFP-LMPVvgrkPDISLVMGAGLLVLLLSL 632 dMlfgktsatksdpaeiqeeEaieresiapfvvPLAiPLiAGPGaIttvi + ++ + s + + eE ++ + ++tv+ NP_036459. 633 CVVTSLMKRKDS-FIK---EELLVHLLQV----------------LSTVL 662 vlmseygsig.....klavvlaillawaityliLlsSsfivrlLGktGin +++ y++ ++ ++ ++ + ++ wa+ l Ss +v lL ++ NP_036459. 663 SMYVVYSTQSsllrkQGLPLMNQIISWAT-----LASSLVVPLLSSPVL- 706 aitRimGLlLvalavQmiv.dGlkgifkglas<-* ++R++ +lL ++ + +++G ++f++++s NP_036459. 707 -FQRLFSILLSLMSTYLLLsTGYEALFPLVLS 737 COG1987: domain 1 of 1, from 669 to 737: score -63.6, E = 89 *->MtsevileLfreal.wlvLilsaPlLlvALvVGLvVS..IFQAaTQI +t++ +l +++l+++ i+s + L +LvV L+ S+ +FQ NP_036459. 669 STQSSLLR--KQGLpLMNQIISWATLASSLVVPLLSSpvLFQ----- 708 qEQTLsFiPKiivvllvLiilGpWMlnkLldFtyelfqnipqvig<-* ++ +ll L+ + Ll ye + +p+v NP_036459. 709 ---------RLFSILLSLMST-----YLLLSTGYE--ALFPLVLS 737 COG2610: domain 1 of 1, from 481 to 740: score -317.1, E = 8.9 *->mttmpLiiillaiilLllLliikfKvhpFlALllaallvgLagGmpl ++ +p ++++i + +L L+ a + ++G+ + NP_036459. 481 SHLLPCSFVAIGILVAFFL------------LIQACPWTYYVYGLLP 515 dkvvssieaGkfGGtLGsvalvigLGAMlGKllEdSGaAesIAdTlirll +++ ++ + f+ ++ d NP_036459. 516 LPIWYAVLRE-FQ------------------VIQD--------------- 531 GekraqlAlvlaglivGipGlFfeVGfilLiPlafalArrakiSlRLklg lv+ ++++p l+ +VG + laf+l +i + L l+ NP_036459. 532 --------LVVS--VLTYP-LSHFVG----YLLAFTL----GIEV-LVLS 561 iP...lagAlsvtHgfvPGTPhPGPlaaAglfGADiGlvllyGlivAipt + +++A +++ ++ P NP_036459. 562 FFyryMLTAGLTAFAAWP-------------------------------- 579 viiggplAKWlgkflgpkklievpeskelgneaelgaekefdeeelPnSf ++ ++ ++ k+ + + + ++ +f + +P NP_036459. 580 -FLTRLW-----TRA--KMTSLSWTF-------FSLLLAVFPL--MP--- 609 gislalillPilLmalkTviatlalpkwpalkgtlvevvefiGsPviAll ++ P + +++ + +ll NP_036459. 610 ----VVGRKPDISLVMGA------------GLL--------------VLL 629 IalLvAiytlglrrgrsmselmdslgegiagiamilLitGAGGaFgqVLv ++l v +++++ ++++el+ +l + +++++ + +V+ NP_036459. 630 LSLCVVTSLMKRKDSFIKEELLVHLLQVLSTVLSM-----------YVVY 668 dSGvGdyLaellsgtgisPlllafvvAalLRiAqGSATVAmiTAaglvaP ++ ++ll g++ l+ +++ + + A++lv+P NP_036459. 669 STQ-----SSLLRKQGLP--LMNQIISWA------------TLASSLVVP 699 llaqlggasgvnpallHRVlAiaaGsvvfSHvNDsgFWlvkgyfglsDvk ll S+v l+ ++f + NP_036459. 700 --------------LL------------SSPV------LFQRLFSIL--- 714 etlKtWtvlttilsvvGlvivlllslvl<-* l ++ ++ ++ ++ l+ls + NP_036459. 715 --LSLMSTYLLLSTGYEALFPLVLSCLM 740 COG1906: domain 1 of 1, from 390 to 746: score -233.0, E = 6 *->mmkvLnsGeqnFvPMvaislLlllFsVvvVlillRKvniGiSifvGa k L q + a s i RK +S+ NP_036459. 390 -FKLLSDSKQFNILRKARSY-----------IKHRKFDEVVSLCKE- 423 liLaiLSGLgidGiLevlyktv......asw.stlrLIviviLimgltgv li L GL + +++ v+ + w s +L +i + ++ gv NP_036459. 424 LIHLALKGLSYYHTYDRFFLGVnvvigfVGWiSYASLLIIKSHSNLIKGV 473 meqiGyLkkmeegllelFpKAkhsllllPaLI..........GLmPMPgG + kk + l +F A l +LI+ + + GL+P P NP_036459. 474 SKEV---KKPSHLLPCSFV-AIGILVAFFLLIqacpwtyyvyGLLPLP-- 517 ALvSApmiepvakkfr.lnpekktliNYWFRHvwelfWPlYpAvVlvSav + v+ +f+ ++ ++ ++ Y H A l+ +v NP_036459. 518 ------IWYAVLREFQvIQDLVVSVLTYPLSHFVGYL----LAFTLGIEV 557 vGisireiSvklFPltilaltiGylffvrklkerlrksRnKvkGLkmlLi + +s + + + lt++a+ + f++r + + s + ++ lL NP_036459. 558 LVLSFFYRYMLTAGLTAFAA---WPFLTRLWTRAKMTSLS--WTFFSLLL 602 nlYPiiiilvlSVllgLdlLyGsfvgllSisipnvariedLkevLkrafq +++P+ ++++ + L + G++v+llS + + k f NP_036459. 603 AVFPLMPVVGRKPDISLVMGAGLLVLLLSLCVVTSLMKR------KDSFI 646 krDIvLLLfaVmvYKsVIenSGlvesilpeivlsFhvPvillLlltPLii k LL+ v V +v s + + P ++ NP_036459. 647 KE--ELLVHLLQVLSTVLSMY-VVYSTQSSLLRKQGLPLMNQIIS----- 688 GlmTGIsfAyvaivLPLLtefftsGivvfkklvLaylgGymGvlLSPvHL +T ++++v PLL +s + + l+ +lLS + NP_036459. 689 -WAT----LASSLVVPLL----SS------PVLFQRLFS---ILLSLMST 720 ClVLSAeYfgaElgkvYrklLlpsvLTlilvgLvYiViiL<-* l LS Y L p+ +l L++++i + NP_036459. 721 YLLLSTGY----------EALFPL----VLSCLMFVWINI 746 COG0733: domain 1 of 1, from 436 to 749: score -359.0, E = 60 *->mmmkrqWsSRlGFILAAaGSAVGLGNIWRFPymageNGGGAFlLpYL + r +L NP_036459. 436 HTYDR---------------------------------------FFL 443 ialllvGiPlll..aEfaIGRYGGrrtrknavdafrrLapkkgkkdsrkw + +++G+ + ++ a + I ++++n + +++ k + NP_036459. 444 GVNVVIGFVGWIsyASLLII-----KSHSNLIKGVSKEV----K---KPS 481 ewvGwfgvavafvIlsyYsViiG..WilsYlvksitGalpgdtdaakfFg + + va++ + ++ + i + +W +Y+++++ ++ + NP_036459. 482 HLLPCSFVAIGI-LVAFFLLIQAcpWT-YYVYGLLPLPIWYAVLREF--- 526 eyFqssingpgdignpvlavfffllfmvitaliVssrGvkkGIEkankil ++ q + + ++++++ f +++ +l + NP_036459. 527 QVIQDLVVS-----VLTYPLSHFVGYLLAFTLGIE--------------- 556 MPlLFvlfiiLviyalTLpGPGAmeGlkfllsPDfsklkddLpkvwlaAl vl + + + G + ++++ + l+ NP_036459. 557 -----VLVLSFFYRYMLTAG---LTAFAA-----WPFLT----------- 582 GQiFFsLSLGfGiMiTYaSYLpKkedlvksalsvvllNtlvslLAGlmiF l + a +++l+ t++slL l++F NP_036459. 583 -------------------------RLWTRAKMTSLSWTFFSLL--LAVF 605 palFvfgaaggkpvsevssGsllaGpGLvFivLPavFnqlpailGtifgi p + v g + ++ + Lv ++a + NP_036459. 606 PLMPVVGRK-------PD-------ISLV----------MGA-G----LL 626 lFFllLvfAaLTSaISmlEvlvaaLidkfg.isRkkatwlvggvifllGv + +l+L v+++++ +k+ i+ + l+ ++ ++l++ NP_036459. 627 VLLLSLC------------VVTSLMKRKDSfIKEELLVHLLQVLSTVLSM 664 psalslggvwsdvliF.GlslFDlvDffasnilmplgaLlivifvgWvfk +++s++ s+ l +Gl+l + ++a+ L++++ v+++ NP_036459. 665 YVVYSTQ---SSLLRKqGLPLMNQIISWAT--------LASSLVVPLLSS 703 kdklrkelnsgsptsdikvgkiWlylvrYf..itPiiiaivlflsaigil + + ++ + + ++ l++ + ++ + P+++ ++ + i+i NP_036459. 704 PVLFQRLFSI----LLSLMSTYLLLSTG-YeaLFPLVLSCLM-FVWINIE 747 se<-* e NP_036459. 748 QE 749 COG0609: domain 1 of 1, from 490 to 750: score -225.3, E = 54 *->llllillllllllls.ilslslGaisistfLfpsdvlqalfgeqiil ++++++ ++ll+ + + + +G +++++ + ++ +q++ + +++ NP_036459. 490 AIGILVAFFLLIQACpWTYYVYGLLPLPIWYAVLREFQVIQD-LVVS 535 dlRLPRilaallvGAsLAvaGailQgltRNPLAdPsiLGissGAalgavl l P ++ +vG LA ++LGi vl NP_036459. 536 VLTYP---LSHFVGYLLA-----------------FTLGIE-------VL 558 aillfpgasssslkrSvilnpyllplaAfiGaliaallvyllarrsgggn ++ +f y ++l A + a++a+ + l r + ++ NP_036459. 559 VLSFF----------------YRYMLTAGLTAFAAWPFLTRLWTRAKMTS 592 ......slspirLiLaGva.....lsalfsAltslllylad.lqqvlfWl + + sl +L+ v+++++++s + +A+ ll++ +++++ NP_036459. 593 lswtffSLLLAVFPLMPVVgrkpdISLVMGAGLLVLLLSLCvVTSLMKRK 642 lGSlsganWsdvllllpivllglilllllarkLnlLsLGddlAksLGvnv +++l + ++ +l+++l+++ ++s+ l + G+ NP_036459. 643 ----DSFIKEELL-VHLLQVLSTVLSMYV-----VYSTQSSLLRKQGL-- 680 erlrllllllvvlLtgaaVavaGpIgFvGLiaPHiaRllvGpdhrylLPl l +++ +++l+ + L++P ++ + + ++L NP_036459. 681 -PLMNQIISWATLASS-------------LVVPLLSSPVLFQRLFSIL-- 714 SaLlGalLLllADilaRtilaPaelPvGivTalilliGavaPyFlYLLrr l L+ +l t +e +v + + +F+++ + NP_036459. 715 ------LSLMSTYLLLST---GYEALFPLVLSCL--------MFVWINI- 746 rrkisletrgrg<-* ++ NP_036459. 747 --------EQET 750 COG0581: domain 1 of 1, from 529 to 751: score -215.6, E = 67 *->vvwfiPnnimvlfmsttanlqakkkvararkiknklatglvfaa..t + + +++++ l+a+ ++ + + ++++ ++ +a+ t NP_036459. 529 IQDLVVSVLTYPLSHFVGYLLAFTLGIEV--LVLSFFYRYMLTAglT 573 lvgllpLvwIiayiilkglaalvnaaegkgtvgleFftkspsppgsegpg ++++ p + +++ +++++l ++ Ff+ ++ ++ + NP_036459. 574 AFAAWPFLTRLWTR--AKMTSL----------SWTFFSLLLAVFPLM--- 608 stvfs..........GGigpAivGTlylillaivIgvPLGVgaAiYLaEY v++++++ + ++G+ +++ l+++++++ NP_036459. 609 -PVVGrkpdislvmgAGLLVLLLS---LCVVTSLMK-------------- 640 akksrvltkvirflidiLasiPSIVfGLFGlgffVvtlglgfSgtslLAG k+s + ++ l+++L+ +l+++Vv+ ++S NP_036459. 641 RKDSFIKEELLVHLLQVLST---------VLSMYVVY-STQSS------- 673 aLtLallmLPivirtTeEALkaVPkslREAslALGatKwqtIkkvVLPaA L + L + + + +A lA + V+P NP_036459. 674 --LL-----------RKQGLPLMNQIISWATLA---------SSLVVP-- 699 mpGIlTGviLaiaRaiGETAPLLfTagvglsqslptdgfPlqlllePgat +L+ P+Lf + +s+ + l+++ NP_036459. 700 --------LLSS--------PVLFQRL----FSILLS------LMST--- 720 LPvhIYtlatspyepeaqalawgaAlvLlilVLlinllarlllrnkrrkk Y l++ +ye a ++ L++ l+ + ++ +++ NP_036459. 721 -----YLLLSTGYE--A------------LFPLVLSCLMFVWIN-IEQET 750 y<-* + NP_036459. 751 L 751 COG0755: domain 1 of 1, from 466 to 751: score -99.0, E = 43 *->vinaipniwlt.iiymllisllaalagplalawlvggllpwsnlyel n+i+ + + ++ +l+ + + +g l +++l+ + pw++++ NP_036459. 466 HSNLIKGVSKEvKKPSHLLPCSFVAIGILVAFFLLIQACPWTYYVYG 512 lllivglilllahgfaladyiqgegevsssfrilyvhvpaalisfmvyvv ll ++ +++ l +++iq v+s ++ + h+++ l++f + NP_036459. 513 LLPLPIWYAVLR----EFQVIQDL--VVSVLTYPLSHFVGYLLAFTLGIE 556 malvavlnlvWlnllvdvafaalallgalftlgavfllrsidd.erseTF +++++++++ +++ + +afaa+ +l l t + + s+ NP_036459. 557 VLVLSFFYRY-MLTAGLTAFAAWPFLTRLWTRA--------KMtSLSW-- 595 WeiilyLltvvvfllsgslwgkptwgahwvwdnlkpnlrltatlvllfly t + +ll++ + p++g + + l++ +ll+l+ NP_036459. 596 --------TFFSLLLAVFPL-MPVVGRKPDIS-------LVMGAGLLVLL 629 gghlgalliltggtpLvlilllqsgtalldvilkrkkagklagilalvlr ++ L++ + l + +++ k+ l +l+ NP_036459. 630 LS-------------LCVVTSLM------KRKDSFIKEELLVHLLQ---- 656 kvalpvklpplgtldlpmyrfivigfplltlgalitgfiwaeeawgrmws l t+ ++ +++ l+ +g + + ++w ++ s NP_036459. 657 ---------VLSTVLSMYVVYSTQSSLLRKQG---LPLMNQIISWATLAS 694 wdpkmvlsfivwl..vyavlLharlekgwrgkkaawltvagfallmiAyf + +ls v+++++++ lL + ++++ + + a+f l++ +++ NP_036459. 695 SLVVPLLSSPVLFqrLFSILLSLMSTYLL----LSTGYEALFPLVLSCLM 740 gvnlvleglhs<-* +v + +e+ NP_036459. 741 FVWINIEQETL 751 COG1007: domain 1 of 1, from 422 to 752: score -341.6, E = 79 *->mdalilvleilnlalllPelillltalvvllvelflsrksRrlylav +l l l++ ++ ++l + +++++ ++s++s l ++ NP_036459. 422 KELIHLALKGLSYYHTYDRFFLGVNVVIGF--VGWISYAS-LLIIKS 465 lsllalvvallsllatalweqgagpkaflgafavDklsliyklviLlsal s l+ +v+ ++ + + ++ s+++ ++ l+a+ NP_036459. 466 HSNLIKGVSKEVKKPS--HLLPC--------------SFVAIGI--LVAF 497 ltllfyaysyaeeansskgEFYaLlLfatlGmivlvssnnLlliFigLEl ++l++ a ++ ++ g +++ +a+l + ++ ++L+ NP_036459. 498 FLLIQ-ACPWTYYVY---GLLPLPIWYAVLREFQVI--QDLV-------- 533 lSLplYiLvalsrdsrrSlEAAlKYfllGalaSafllyGiAllYgatGtL +S+ +Y L + + ++ f+lG + ++ ++++Y + t NP_036459. 534 VSVLTYPLSHFV-GYLLA-------FTLG-----IEVLVLSFFYRYMLTA 570 dLsgIalalknagednplLlllGlvfllvGlaFKlsaVPFHfWtPDVYeG +L + NP_036459. 571 GLTA---------------------------------------------- 574 APtpvvAFlStapKiAaFvvllRlfvtafgtdliafdtpdwylvfavLAv +Aa +l+Rl + a t + w+++ +LAv NP_036459. 575 --------------FAAWPFLTRLWTRAKMT------SLSWTFFSLLLAV 604 lSMliGNlaALtQtnvKRmLAYSSiaHaGYlLiglaavtkggnadkslgl + L+ +++ +++ sl++ NP_036459. 605 -----------------------------FPLMPVVGRKPD----ISLVM 621 sAglfYllvYafmslGaFgvlallegldrgvgaesYadisdykGLlkrhP Agl ll sl +++ l+ ++++ +++ L + NP_036459. 622 GAGLLVLLL----SLCVVTSLMKRKDSFIKEE--L---------LVHLLQ 656 llAallsivlf.....SLA...GIPPlaGFwGKfyvfaaavqsGhlwLav +l +ls++++ ++++SL++++G+P ++ + s +La NP_036459. 657 VLSTVLSMYVVystqsSLLrkqGLP-----------LMNQIIS-WATLAS 694 lavlnGSaisayYYlRvvvamffeepeqe....Pinqnpvgngekvvvla v+ ++ p +++ +i + +++ + +l NP_036459. 695 SLVVP----------------LLSSPVLFqrlfSILLSLMST---YLLLS 725 salavlvlGilpnpvidlvkksaalnLl<-* + + l+ ++l ++ + ++++ +++ L NP_036459. 726 TGYEALFPLVLSCLMFVWINI-EQETLQ 752 COG1296: domain 1 of 1, from 526 to 752: score -155.2, E = 74 *->llknkedmnlssaminahespRqItaaFkqGfpaslPiviGylPwgl + +d+ s+++ +++ + Gyl +++ NP_036459. 526 -FQVIQDLVVSVLTYPLSHF-------------------VGYL-LAF 551 afGvlakqlGlSvlEallMSlliyAGAsQFvA.....igLlaagasllsi ++G+ l + + ++l + l+ +A A F ++ +++ + + ++s+ NP_036459. 552 TLGIEVLVLSFFYRYMLTAGLTAFA-AWPFLTrlwtrAKMTSLSWTFFSL 600 iltTllvNaRHlLYGlSlrsklsrltlkkrvylaFgLTDEvFAlavssav +l+++ + + +k ++ l+ ++l+ +L +l+v+ + NP_036459. 601 LLAVFPLM-------PVVGRKP-DISLVMGAGLLVLLL----SLCVVTSL 638 RrkrvnkgwfmlGveLssylsWvlgtl....vGalaGStLpadrPfnqqG kr+++ + eL+ +l vl+t+ + v ++ S+L+ qG NP_036459. 639 -MKRKDS---FIKEELLVHLLQVLSTVlsmyVVYSTQSSLLR-----KQG 679 LeFv...mtAlFiv..LlipnvkkrlsvlvsaltGLvlavlfl.lLfgse L +++ ++ + ++++L++p++ + vl l +++l++ ++ lL +++ NP_036459. 680 LPLMnqiISWATLAssLVVPLLSSP--VLFQRLFSILLSLMSTyLLLSTG 727 vfilaallamllgltllrkkleapa<-* + l l++ +l + + +e+ NP_036459. 728 YEALFPLVLSCLMFVWINIEQETLQ 752 COG0842: domain 1 of 1, from 424 to 753: score -92.8, E = 40 *->kfrali.ellrllrdpllllliilpplllllifgygf.gtldlpvav +++++++ l + + + +++++ ++++++++ ++++ NP_036459. 424 LIHLALkGL--SYYHTYDRFFLGVNVVIGFVGWISYAsL-------L 461 vdedqsalsrqli.elkatslflrkllvltlrelkrflrsr.....geii ++ ++s l + ++e+k s++l+ ++v+ + + fl + + +++ NP_036459. 462 IIKSHSNLIKGVSkEVKKPSHLLPCSFVAIGILVAFFLLIQacpwtYYVY 511 galviPedflwlllfgfalvi.vigggqdgeivaysaevggasdylayvl g l P ++ a++ ++++ +++ ++++l+y l NP_036459. 512 GLLPLP--------IWYAVLReFQVIQDL------------VVSVLTYPL 541 pglalmavls.aslfgvisalfdrrssyfvypaaesvialrlGtlerllv ++ + +++++++++ + +f r + l + + NP_036459. 542 SHFVGYLLAFtLGIEVLVLSFFYRY--------------MLTAGLTAFAA 577 sPlsrlsillgrilasllrsllqaailrglvillllalflllfgfivfgi P + + ++++++++++ + ++ ++ l+ ++++ + +++ NP_036459. 578 WPFLTRLWTRAKMTSLSWTFFSLLLA--------VFPLMPVVGRKPDISL 619 plsgsllllll........................avllsvlltlglgal + +ll+lll+ ++ +++++ +++ + + +ls++l++ + + NP_036459. 620 VMGAGLLVLLLslcvvtslmkrkdsfikeellvhlLQVLSTVLSMYVV-Y 668 lislvlallvstpetagaiasllilpliflSGvfyPlellPdwlqwiaya ++ +++ ++++ +i +++ S +Pl + P +q + ++ NP_036459. 669 STQ-----SSLLRKQGLPLMNQIISWATLASSLVVPLLSSPVLFQRLFSI 713 nPltyavealRylllgaglsdvwfsllvLallgllllllgllllrrrekk + ++++ +ll ls + l +L+l +l++ ++ +e++ NP_036459. 714 L-----LSLMSTYLL---LSTGYEALFPLVLSCLMF----VWINIEQETL 751 ar<-* + NP_036459. 752 QQ 753 COG1280: domain 1 of 1, from 592 to 753: score -112.1, E = 70 *->mmdmsfllafligslalslalsPGPdnllvlsnslkyGfraGllaaL ++ ++f++ +l++ + ++ + G++ + ++ NP_036459. 592 SLSWTFFSLLLAV--FPLMPV---------------VGRKPDISLVM 621 GlalGdavhvlLaalGla....aLlktspllFtlLkllGAaYLlYLGvqm G++l ++++ l +++ l +++++++k +ll +lL+ l + Y +++ NP_036459. 622 GAGLLVLLLSLCVVTSLMkrkdSFIK-EELLVHLLQVLSTVLSMYVVYST 670 lrskgkkleasesaasplsrswklflrGlltnllNPKaiLFflsllpqFi s +k+ ++ + +s + +l ++++ NP_036459. 671 QSSLLRKQGLPL-MNQIIS----------------------WATLASSLV 697 dpqaslaslaqllvlgaiivlvdllwfsllAllgsrlarllrsnprfqrv p s++ vl+ ++ + l +s + ll + +l+ + NP_036459. 698 VPLLSSP------VLFQRLFSILLSLMSTYLLLSTGYEALFPL------- 734 lnrlaGllLigfGvklllsrl<-* l+ l+++ + + + + NP_036459. 735 --VLSCLMFVWINIEQETLQQ 753 COG0555: domain 1 of 1, from 586 to 754: score -187.5, E = 35 *->lpgfwlllglgallflllfllLPliaifs.....ralglgwalflaa ++++ +l+ f +l+l+++ + ++++++++ l +g++l+ NP_036459. 586 TRAKMTSLSW---TFFSLLLAVFPLMPVVgrkpdISLVMGAGLLV-- 627 ildPdvlaAlklsLltAliatllnlvfGvplAwvLaRfeFpGKrlldali l lsL +++ ++ R++ K + l+ NP_036459. 628 ---------LLLSLCVVTS--------------LMKRKDSFIKE--ELLV 652 dLPlvLPPvVaGlaLlllfGrnGplGqwledvfGiqivF...swpGiVlA +L+ vL++v l ++++++ + + l + G++++ + sw + lA NP_036459. 653 HLLQVLSTV---LSMYVVYSTQ---SSLLRK-QGLPLMNqiiSW--ATLA 693 qlFVslPFvVrelqpvlesvdrelEeAArtLGAspwqtFfrVtLPlilpg + V +P++ ++ +q +f+++L l NP_036459. 694 SSLV-VPLLSSPVL---------------------FQRLFSILLSLMST- 720 llaGviLaFARalGEFGAVlmvaGNIpGkTrTlPlaIylalesgdyeaAf yl+l++ +ye NP_036459. 721 -------------------------------------YLLLST-GYE--- 729 alavvLlliSlivLlllnilggrqrrsgrr<-* a++ l++S ++++ +ni q++ ++ NP_036459. 730 --ALFPLVLSCLMFVWINIE---QETLQQS 754 COG1263: domain 1 of 1, from 427 to 756: score -248.7, E = 55 *->kkknmnpflqflgkaasIFmppIpaLpaAGlLlGlgnlltnfgwvfs + + ++ +++ +lG++ ++ +gw NP_036459. 427 LALKGLSYYHTYDRF----------------FLGVNVVIGFVGW--- 454 eg.slylinpfdalvlpilkaaGdavFafLPlLfAigaAigFgKdgdGta + ++li +k ++ + g++++ K ++ + NP_036459. 455 ISyASLLI----------IKSHSNLI---------KGVSKEVKKPSHLLP 485 gLaaviGyllvhptllailglgglttfgelgeaegavlvwtfepAitsvl + +iG ++++ l NP_036459. 486 CSFVAIG--ILVA---FFL------------------------------- 499 GiptidtgvygGiiiGiL.laalynrfieikLpkflpfflglrfVPiitl +i+ + ++ + G+L+l +y L++f +++ ++V +t NP_036459. 500 ---LIQACPWTYYVYGLLpLPIWYA-----VLREF--QVIQDLVVSVLTY 539 litgplaliligpwppiqgginsfglllvysGsggavggaifGgierlLv + +++++l + +++ + f +++ +G+ ++++ +++ ++ NP_036459. 540 PLSHFVGYLLAFTLGIEVLVLSFFYRYMLTAGLTAFAAWPFLTRLWTRAK 589 pfGLHHifyaifwfliaggseytngagGevvsGdLnrFfagdstpllgvl ++ L ++f ++ + ++ NP_036459. 590 MTSLSWTFFSLLLAVFP-------------------------------LM 608 ftaGg......FmtglfPimmfGlpAqalAmlavakkekRkkvag..... ++ G +++ + m + ++ ++l + ++ +++ +++ NP_036459. 609 PVVGRkpdislVMGAGLLVLLLSL------CVVTSLMKRKDSFIKeellv 652 ..llisaAltsfLtGITEPAiyEf..tflfva..PfLyAaIhAalaGasf + l+++++ s++ ++y ++++l++ + P+ I ++++ as+ NP_036459. 653 hlLQVLSTVLSMY------VVYSTqsSLLRKQglPLMN-QIISWATLASS 695 glanvlgvriGltFSgGfIDfvllpglasiqpsgtnwwlvyviGlviAai + +l+ + l+ l+si s++ ++l +++ NP_036459. 696 LVVPLLSSPV------------LFQRLFSILLSLMSTYL------LLSTG 727 yyfvFtfligkfnlktpgredeedskeeesaska<-* y +F +++ ++ + + e +e+ + s+ NP_036459. 728 YEALFPLVLSCLMFVWINI---E--QETLQQSGV 756 COG1175: domain 1 of 1, from 535 to 757: score -184.7, E = 10 *->wlayllllPalllfllFiyyPlietlaiylSFtdwdgfppaaaqitp ++ l+ ++ ++l+F++ +++l++++ ++ g++ NP_036459. 535 SVLTYPLSHFVGYLLAFTLGIEVLVLSFFYRYMLTAGLTA------- 574 gesefVGlkNfvrlftlfs....DptFwqalknTllyt.........lls + + +l rl+t ++ ++ tF++ l + +++ +++++ l+ NP_036459. 575 -FAAWPFLT---RLWTRAKmtslSWTFFSLLLAVFPLMpvvgrkpdiSLV 620 vplqlvlgLllAlLLnqkrlkGrglfRtllflPyaiSpVvaaliWkflFn + +l++ Lll l++ +k + f +l + + + + l + +++ NP_036459. 621 MGAGLLV-LLLSLCVVTSLMKRKDSFIKEELLVHLLQVLSTVLSMYVVYS 669 prdsfGliNqlLnllGidpppviaipWlndpfwAllaiilvnvWkgtgfn + + l ++ l+++ + W ++ NP_036459. 670 T-Q---------------S-------SLL-RKQGLPLMNQIISWATL--- 692 mlifLAgLQsIPqeLYEAAriDGAsrwqrFrhITLPlLrPtilfvlilst As++ ++PlL+ + lf +s+ NP_036459. 693 -----------------------ASSL------VVPLLSSPVLFQRLFSI 713 igafqvFdeiyllTgGGPagGPpvgnaTdtlalyiYreaFeggpQdfGyA + ++++ T++l++ Y+ +F NP_036459. 714 LLSLMS---------------------TYLLLSTGYEALFPLV------- 735 sAiavilflivliltliqfklfkrkveegs<-* l +l +++i++ + ++ NP_036459. 736 --------LSCLMFVWINIEQETLQQSGVC 757 COG1301: domain 1 of 1, from 434 to 757: score -316.1, E = 83 *->lfakkikmsLyvkiliGlvlGilvGlvlpelgapdgFvkyavatalk +++ ++ L v+++iG+ vG++++ a +++k NP_036459. 434 YYHTYDRFFLGVNVVIGF-----VGWISY-----------ASLLIIK 464 plGdlFirLiKMlvaPlVFfslVlGiasigdmkklGrvGgktliYflvtT ++l i+ ++ ++++++ l l + NP_036459. 465 SHSNL-IKGVS---------------KEVKKPSHL-----------LPCS 487 tlAlliGLilanvfqPGlvGadlspaatldpsevaeytqataeshieila ++A++i +++++++q + + + + l+ + + a NP_036459. 488 FVAIGILVAFFLLIQAC--PWTYYVYGLLPLPI--------------WYA 521 tl..ldiiPtNpfsAfa..........eGniLqilfFAillGlAlsllgS +l++ ++i + ++s+++ + ++ + + +L+i +l+ +++ + NP_036459. 522 VLreFQVIQDLVVSVLTyplshfvgylLAFTLGIE---VLVLSFFYRYM- 567 eegrepvlnlfeglsevmfkivnfvmklAPiGvFgLmAntvakfGlgsLl ++ + ++ l+ + + k++ + ++t+ ++ l ++ NP_036459. 568 LTAGLTAFAAWPFLTRLWTRA-----KMTSL------SWTFFSL-LLAVF 605 pLakLvl......vvylalllfafVVlglilkifgr.fspfk..flryCl pL +v+++++ ++v +a ll++++ l ++ +++r+ s++k+++l + l NP_036459. 606 PLMPVVGrkpdisLVMGAGLLVLLLSLCVVTSLMKRkDSFIKeeLLVH-L 654 re......alltAFsTsSSeAtLPvlMekaeknlGvsksvvsFViPLGat + ++ ++ +++sT+SS + k G++ NP_036459. 655 LQvlstvlSMYVVYSTQSS---------LLRK-QGLP------------- 681 iNmDGtvaiyltvaalFiAqayGidLslgqqlllvlvatLaSkGaAGVPG + + + +A+ + ++L + + vl L+S+ NP_036459. 682 -------LMNQIISWATLASSLVVPL----LSSPVLFQRLFSI------- 713 gglivLaatLsavGhiPleGAmqvlAlIlgiDrilDmaRTalNvtGDala L+++ s++ + +G + +++ ++ NP_036459. 714 -----LLSLMSTYL-LLSTG----YEALFP-----------------LVL 736 taivakwEgeldakklrraldGrlaerksdse<-* +++ w++ +++++ ++s + NP_036459. 737 SCLMFVWIN-IEQET----------LQQSGVC 757 COG1955: domain 1 of 1, from 296 to 759: score -384.7, E = 44 *->mAAEAEGEHvEsEGslidvkfgEkveivvkvglnprkyllrilapal + A + E l k v ++++ p ++ l + ++l NP_036459. 296 VSAQQFDDAFLKEWRLENWK----RLDVNQADIAPLMTSLIGVPFPL 338 vgsvvLflvtivfiralmlptglvlalyLllpllilafavaypylradsk ++L + l+++ +++ ++ + + +k NP_036459. 339 NSVGILPVDY---LNNTDLFKAESMFTN-------AVQILEQFKVKMTQK 378 rlsinsrLlyfITymavLSTsnlnrteilrilsekpeeyGplskEfrKiy + + L++ T + +LS s+ + il + y +k f ++ NP_036459. 379 KEV---TLPFLFTPFKLLSDSKQ-----FNILRKA-RSYIKHRK-FDEVV 418 dLvdkWgrSLaeAcrfiAkrtpSeifaDfLdRLAyaldSGedleEFLerE L +++ + ++ + NP_036459. 419 SLCKEL---------------IHLALKGL--------------------- 432 qravmddYetfYeraLySldvykdi.....YvSlll..SivFllafvivl +Y +Y r v + + +Y Sll+ +S + l+ v NP_036459. 433 ------SYYHTYDRFFLGVNVVIGFvgwisYASLLIikSHSNLIKGVSKE 476 P....ILlganDitrtltlsafavtaielllvlvifkrlPkDplwhegei +++++ Ll+ ++++ l+af + + + ++ +lP p+w+ NP_036459. 477 VkkpsHLLPCS-FVAIGILVAFFLLIQACPWTYYVYGLLPL-PIWYAV-- 522 kTkrdiklkrlaiiaialaaivllFliyavtllnltgplftlPvpfyaAv l+ i ++ ++ l +v+ l + NP_036459. 523 -------LREFQVIQDLVVSVLTYPLSHFVGYL----------------L 549 gltPAGLVLlyvGyvARkEEgkVkkkDEaFpaFIRSLGsslSaaGnslvk +t+ G+ l +++ R + L + l+a + NP_036459. 550 AFTL-GIEVLVLSFFYRYM-----------------LTAGLTAFAA---- 577 aLeyLsahnFGiLtedIkrLYkRLalriDsnkAWdlFsAetGSyLIqkfS rL +R ++ ++++W +Fs ++ NP_036459. 578 -------------WPFLTRLWTRAKM---TSLSWTFFS---------LLL 602 eIFvesidlGGdPdl.....vGevISenfeeiVr.LRkkRyqsvSt..Fv ++F G Pd + ++G ++ + +V +L k++++ + + +v NP_036459. 603 AVFPLMPVVGRKPDIslvmgAGLLVLLLSLCVVTsLMKRKDSFIKEelLV 652 GilyGlhgAlaGfsLfIslgvaklidgIfskFsvplgGeevgsIfniiPG +l l+ l + v + ++++ k +pl I++ + NP_036459. 653 HLLQVLSTVLS------MYVVYSTQSSLLRKQGLPL----MNQIISWA-- 690 GmqGLNiGiFpssdvdLleill..viillvlsiisslaikVvdGGhkvns + ++++l+++v++ si+ sl+ + +++s NP_036459. 691 ----------TLASSLVVPLLSspVLFQRLFSILLSLMST-----YLLLS 725 LyyfVillwisaivmyvtleivksllsvivvsvvlv<-* y +++ ++ + +m+v i l + +v NP_036459. 726 TGYEALFPLVLSCLMFVWINIEQETLQQS--GVCCK 759 COG3202: domain 1 of 1, from 392 to 759: score -363.3, E = 14 *->mnstspeeksfsKLRailWPIrryElkKFlPmf..LlmFcI.lfNYn +s s+ + K R++ I+ + ++ + ++L ++++++ Y+ NP_036459. 392 LLSDSKQFNILRKARSY---IKHRKFDEVVSLCkeLIHLALkGLSYY 435 lLRsiKDsLVVtgigaGAEvIpFLKlWgvlPsAviftiiYaKLsniLkre + D + ++ + vI+F ++ + + +++ + L+ ++e NP_036459. 436 ---HTYDRFFLGVNV----VIGF--VGWISYASLLIIKSHSNLIKGVSKE 476 ..qvFylivsfFLgFFaLFAfVIYPngdilHpnpklidkLqailPnGlKW ++ l+ F++ +L Af + L+ + P+ NP_036459. 477 vkKPSHLLPCSFVAIGILVAFFL----------------LIQACPW---- 506 FIvivgkWSyalFYilaELWpsvvlsLLFWqFANeITkieEAKRFYaLFg +Y+ ++ l L W Ya++ NP_036459. 507 -----------TYYV----YG--LLPLPIW---------------YAVLR 524 lgaNlslllaGevivwlskqyflaeklaidsYnsssnhilLqpittiili + + l+++++++ ls +f+ + la + ++L ++ +l+ NP_036459. 525 EFQVIQDLVVSVLTYPLS--HFVGYLLAFTL---GIEVLVLSFFYRYMLT 569 sGiiiialyrlInklvltaprPPlkrvlylpniatkkkkk.ektklKlsl +G+ + a ++ +l a++ l + + +a+ ++ + + k+ +sl NP_036459. 570 AGLTAFAAWPFLTRLWTRAKMTSLSWTFFSLLLAVFPLMPvVGRKPDISL 619 ieSfkyilrSrYlgllAllviaYglaINLvEgvWKskvkelYPtrvdYta ++ +++ +ll l+v v+ l + + ++ NP_036459. 620 VMGAGLLV-----LLLSLCV-----------------VTSLMKRKDSFIK 647 FmGnflfwtGvvtvvfmlFiG....gniiRrvGWltgAlvTPlmmliTGv + +++ +tv++m + +++++++R+ G +Plm i NP_036459. 648 EELLVHLLQVLSTVLSMY-VVystqSSLLRKQG-------LPLMNQI--- 686 lFFgfiiFeqqigsifaglllssPLvLAVviGgiQNVLSKstKYsLFDaT i + ++s++ ll s+ NP_036459. 687 -----ISWATLASSLVVPLLSSP--------------------------- 704 KEMAYIPLddElKtKGKAAiDVvgaRlGKSgGaliQsglfiifpsaafia + + lf+i++s+ NP_036459. 705 ---------------------------------VLFQRLFSILLSLM--- 718 iipvLavi.....filicilWIyavkkLnkeYqaaialsek<-* ++ +L++++ + f l+++ ++ + + +e + ++ + k NP_036459. 719 STYLLLSTgyealFPLVLSCLMFVWINIEQETLQQSGVCCK 759 COG0004: domain 1 of 1, from 506 to 762: score -350.1, E = 11 *->mkratfsWlerlwallvlslvatalaqdepatNvsavttvldsgDta ++++ + l + +++a + NP_036459. 506 WTYYVYG------LLPLPIWYA----VLRE----------------- 525 WmLlsaaLVllMtPGlAllYgGlvRaKNvlntimkslvdfaivsllW... ++++ d+ +++l ++ + NP_036459. 526 ---------------------------------FQVIQDLVVSVLTYpls 542 ffvGYSLAFGddagvvngFiGtlgffllgnvl.......lpdlvffaFQl fvGY LAF + +++ +l+ +++ + +l +++ + F NP_036459. 543 HFVGYLLAFTLG----------IEVLVLSFFYrymltagLTAFAAWPFLT 582 mFAaitvaIIsGAvAERmKF..sAyLlFsvLwttlvYpPvAH......WV R+K+++ + Fs L + + Pv ++++ ++V NP_036459. 583 R------------LWTRAKMtsLSWTFFSLLLAVFPLMPVVGrkpdisLV 620 WGggGWLaklGfmaLDFAGGtVVHingGfaALaaallLGkRkGkydddGk G+ G L l +++V l+ ++ + + NP_036459. 621 MGA-GLLVLLL--------SLCV----------VTSLMKRKDSFIKE--- 648 pnaipPHNipmvvLGaalLWFGWFGFNaGSAlaangeanggvaalafvnT ++ H lL + + + +++++ T NP_036459. 649 --ELLVH----------LL-----------QVLST-----VLSMYVVYST 670 nlAAAaGmlgWmliewlrnGrKPtvlglasGavAGLVAITPaaGfVspwg + + l + + l l++ ++ + ++ + NP_036459. 671 Q-------------SSLLRK---QGLPLMNQIIS----------WATLAS 694 AliIGlvAGvicylavkllkkklkiDDaLDvfgVHGvgGvwGtiltGiFA +l++ l+++ + l+++++ +il + NP_036459. 695 SLVVPLLSSPV------LFQRLF-------------------SILLSLMS 719 apsvgamagisslgaGgllgGnqmlkQLgvQiigvvvvaayafvvtfill + + ++++ y +++ ++l NP_036459. 720 T--------------------------------YLLLSTGYEALFPLVLS 737 kllkltlGgLRVSeeeElvGLDlseHgetAYseeevi<-* l+ +++ e+E + ++++ ++ NP_036459. 738 CLMFVWIN-----IEQETL-------QQSGVCCKQKL 762 COG1174: domain 1 of 1, from 471 to 763: score -216.3, E = 39 *->yapnrlvlgeGR...alaalalqtiwaLvavgaAllaaGfiPakgsi + v+ e ++++l +i Lva a + NP_036459. 471 ----KGVSKEVKkpsHLLPCSFVAIGILVAFFLLIQACPWTYYVYGL 513 valilayvvfdtlvkfllplanqvaefvDwlvttfggfFdgisdtlalli +l+ y v+ ++ + +v + t ++ F+g + + l i NP_036459. 514 LPLPIWYAVLREFQV--------IQDLVVSVLTYPLSHFVGYLLAFTLGI 555 ggfkqlllfl.pllllillfallalvasalglallallstmklllieglg ++++ ++ + l +++ +fa+ +++ ++++ a ++ ls NP_036459. 556 EVLVLSFFYRyMLTAGLTAFAAWPFLTRLWTRAKMTSLS----------- 594 lwdltlqHLaLvlvavllailvGV.PLGIlaaRprsprlaglvfpllnvm w +++++l++V PL +++R +p + +lv+++ NP_036459. 595 -W-------------TFFSLLLAVfPLMPVVGR--KPDI-SLVMGA---- 623 QTiPslAlLalllpvfGaLglGirGlGlvPAIvAlv..........LYal +ll+++++ ++ +l++++++ +++L NP_036459. 624 ---------GLLVLLLS-----------LCVVTSLMkrkdsfikeeLLVH 653 LPivRnTylGlrqVpaeviEAAraiGmtpaQrLlkVeLPLAlPvIlAGiR L v +T+l + V +t +L+k LPL NP_036459. 654 LLQVLSTVLSMYVVY-----------STQSSLLRKQGLPL---------- 682 talvlaigmatIAa.....lIGAGGLGdlifrGlntlntglilaGalpva + + i++at+A++ +l + L + +f l +l +++l+ a NP_036459. 683 --MNQIISWATLASslvvpLLSSPVLFQRLFSILLSLMSTYLLLSTGYEA 730 lLAillDrllqllerkltpkglrrrkatkkvkvs<-* l+ ++l l+ + + +l+ ++ k+k++ NP_036459. 731 LFPLVLSCLMFVWINI-EQETLQQSGVCCKQKLT 763 COG1455: domain 1 of 1, from 455 to 768: score -306.8, E = 11 *->MklMsaviqilEkklvPiAgKignqRhlqALRDGFilaMPLiIiGSf + s+ i ++ l+ ++K + + + L F+++ +i++ +f NP_036459. 455 ISYASLLIIKSHSNLIKGVSK-EVKKPSHLLPCSFVAI--GILV-AF 497 fLlitNLPfsfasqnfm.ysvflvllaewkgilgnpfnasmgIMslfvvf fLli P + +++++ ++ +l e++ i ++++ +++ + NP_036459. 498 FLLIQACPWTYYVYGLLpLPIWYAVLREFQVIQDLVVSV----LTYPLSH 543 GIgYnLAksYkvdAlsaGlLSlaaFlllTpysDWvPftvdgesvaamtGg ++gY+LA + + l +LS + lT +G NP_036459. 544 FVGYLLAFTLGIEVL---VLSFFYRYMLT------------------AG- 571 vIPvdDaRlLGakGiFtAmiiaifsvEiYrfivqkPNlvIKmPdsVPPAV ++a+ + + +++ + Km NP_036459. 572 -------------------LTAFAAWPFLTRLWTR----AKMT------- 591 skS...FeALIPafiillVvll...inlivqatfgtllhd..iimsllqt s S + F++L+ +f ++ Vv+ +++i+l a + ll ++ sl++ NP_036459. 592 SLSwtfFSLLLAVFPLMPVVGRkpdISLVMGAGLLVLLLSlcVVTSLMK- 640 PLaslgsslggtLiavfvvqLLWFfGiHGaniitALDngvlaPIwlenid +s++ +++v+LL ++ + ++ NP_036459. 641 ----RKDSFI---KEELLVHLL--------QVL------------STVLS 663 tYqqYaNieAflaGeplPhIftkpFldiFTVfiGGSGATLa..Lvlaill Y Y+ + +l + lP +++ + ++ ATLa++Lv+ l NP_036459. 664 MYVVYSTQSSLLRKQGLP-LMNQ--IISW--------ATLAssLVVPLLS 702 fskskqlKqvGkLslpPGlFNINEPIiFGlPIVMNPiLfiPFvLaPminv + P ++ ++ + NP_036459. 703 S---------------------------------------PVLFQRLFSI 713 tvtYiamssGlVapPvgvaVPWTmPafinAflaTggsvagllLqLvNLii +++++++++ l+Tg +L+ L++ NP_036459. 714 LLSLMSTYL---------------------LLSTGYE------ALFPLVL 736 sfliYLPFvkaldkqklaqEkeveseetaAqagdk<-* s+l+ Fv + +q q + v +++ NP_036459. 737 SCLM---FVWINIEQETLQQSGVCCKQKLTSIQFS 768 COG0392: domain 1 of 1, from 475 to 773: score -109.4, E = 93 *->mkrfilivlgvlavaliflflgirrgieiisalkranpvflllaill ++ ++ l++ ++ +i ++ + ++ + +++ ++++l NP_036459. 475 KEVKKPSHLLPCSFVAIGILVAFFL------LIQACPWTYYVYGLLP 515 lllvlllwgilrwkillrvlgikvsfrraflllfvslflnnitPfsrGgg l ++ +++ r ++++++++ ++l++ +s f++ + f +g NP_036459. 516 LPIWYAVL---------REFQVIQDLVVSVLTYPLSHFVGYLLAFT-LGI 555 elvryyllkklpkaevfvlafaavaaervldlaallvgvisflrllarlg e+ + ++ +++++ ++afaa + l ++a ++ +s+ +++ l+ NP_036459. 556 EVLVLSFFYRYMLTA-GLTAFAAWPFLTRLWTRAK-MTSLSWTFFSLLLA 603 ltel......faeisviillsilgiilgllvlailif...iavsksalsr ++ l + ++ +is+ ++l ++l+l+v + l+ ++++++ +++l++ NP_036459. 604 VFPLmpvvgrKPDISLVMGAGLLVLLLSLCVVTSLMKrkdSFIKEELLVH 653 lvllilgfrriffaklalaeelllkriekikrefkagyerlrkpkrrlll l + +++++ ++ ++ ++ ++k++l l NP_036459. 654 LLQVLSTVLSMYVVYS---------------------TQSSLLRKQGLPL 682 afllSllswlldilalyllflalglsvstsqflfvllvflvallvgvvis + +sw+ la+ l++ +l+++v ++ l++ l++l+++ ++ NP_036459. 683 MNQI--ISWA--TLASSLVVPLLSSPVL----FQRLFSILLSLMST-YLL 723 ltPGpgGlGvvEavmiallsalg.....isksvalaalllwRlisyylpt l G +Ea + ++ls l +i+++++ + NP_036459. 724 LSTG------YEALFPLVLSCLMfvwinIEQETLQQS------------- 754 llGaisllylelqklkkklkkk<-* +++ ++++ +++ + NP_036459. 755 ---GVCCKQKLTSIQFSYNTDI 773 COG1292: domain 1 of 1, from 409 to 795: score -463.1, E = 67 *->msrRgtmlkemekytsinPpVFyisaalIlalvllgvlfpdqaqavl + R ++ ++ + + l+l g+++ + + + NP_036459. 409 IKHRKFDEVVSLCKE-------------LIHLALKGLSYYHTYDRFF 442 nraqswitnnfGWfYlLavtlfLv...FvlflafSrYGkIRLGkddekPE ++ ++++ +GW + +++l++++++ l+ +S k+ kP NP_036459. 443 LGV-NVVIGFVGW--ISYASLLIIkshSNLIKGVS--------KEVKKPS 481 FSflSWlaMLFaAGmGigLlFWGVAEPvshysWtdPPfGvpetpttqAar + L ++ +ig+l v + NP_036459. 482 H-------LLPCSFVAIGIL-------VAFF-----------L-----LI 501 qAlaytfFHWGLhaWAiYalVALalAYiFqyRkglplalSSaLyPllGer qA ++t + +GL + i++ V + +++l +S yPl NP_036459. 502 QACPWTYYVYGLLPLPIWYAV------LREFQVIQDLVVSVLTYPL--SH 543 rvnGpiGhaVDifaviATvfGvATsLGlGalQinsGLsyLfgwGipnsfw ++G+ l ++ G+++L+ + ++ NP_036459. 544 ----FVGYL---------------------LAFTLGIEVLV-LSFFYRYM 567 vqlaiIavvtglatlSvvsGvnkGIriLSniNmaLAflLLLFVLvvGPTl +++++ a ++++ + T+ NP_036459. 568 LTAGLTA-------FAAWPFL---------------------------TR 583 flLnsfvdniGdYlqnlvqmsfrtdPydpegqetdleWlggWTiFYWAWW + + +++ ++ l++ f++ P +g+ NP_036459. 584 LWTRAKMTSLSWTFFSLLLAVFPLMPV--VGRK----------------- 614 IsWaPFVGlFIARISRGRTIREFivGVLliPtlftllWftVF........ P +l ++ ++Ll+ +l+ ++ + ++++++ + NP_036459. 615 ----PDISL-------------VMGAGLLVLLLSLCVVTSLMkrkdsfik 647 GntALylqinggagilgevategpetalfqlLehLPlg.tvtsvvavlvi + ++l + ++l + + +++ +l + + LPl + ++s+ ++ NP_036459. 648 EELLVHLLQV-LSTVLSMYVVYSTQSSLLRK-QGLPLMnQIISWATL--- 692 lvFfvTSaDSgslVLaalssrgksegldPplwvRvfWgvLigavaavLLl + slV+ lss +R+f ++L +++ LLl NP_036459. 693 ---------ASSLVVPLLSSPVL--------FQRLF-SILLSLMSTYLLL 724 sGGggLeALQTaviiaALPFslilLvmvaslyKaLkadardirkaaqsla s g eAL F l+l ++++ ++ ++++ q NP_036459. 725 ST--GYEAL----------FPLVLSCLMF---VWI---NIEQETLQQ--- 753 prrvglsdrdlwkrRlhqimaapsqtdverfmktvalPAmeevkeel<-* +g+ + k + q + ++ t+ ++ ++ + A v ++ NP_036459. 754 ---SGVCC--KQKLTSIQFSYNTDITQFRQLYLDDIRRAFFLVFFLV 795 COG0843: domain 1 of 1, from 340 to 796: score -467.4, E = 21 *->mfgKlsldavpvhdPl...Vlvaqamialedlaimnattyfkkwkkl g l d d+ + + + + a+ +le + ++ + + l NP_036459. 340 SVGILPVDYLNNTDLFkaeSMFTNAVQILEQFKVKMTQKKEVTLPFL 386 wyrwitTvDHKkIGimYivvailmflvGGllAllmRlQLAlPsGGlqfld ++ + D K + i+ +++ ++ NP_036459. 387 FTPFKLLSDSKQFNIL-------------------------RKA-RSYIK 410 pndqtYNqllTmHGvIMiFffamPflfGGfaNyvvPLqIGArDvAFPrLN + +++ ++ + ++ L ++ NP_036459. 411 H--RKFDE-----------------VVS-LCKELIHLALKG--------- 431 alsFWL....fvlGaiLlasslfipGGaAqvGWTfYpPLsannysspGvG ls+ + ++f+lG +++ +++ vGW +Y+ L + ++s NP_036459. 432 -LSYYHtydrFFLG---VNVVIGF------VGWISYASLLIIKSHS---- 467 vdfyilaLqLsGlGsllggINFivTilkMRapGmtlfkmPl.Ft.WtiLi N+i + k ++ + + +P +F+ +iL+ NP_036459. 468 --------------------NLIKGVSKEVKK--PSHLLPCsFVaIGILV 495 TsiLillafPvLtvalalLllDrslGThFFtpvgGGdplLyqhLFWFFGH +++L++ a+P lL l+ NP_036459. 496 AFFLLIQACPWTYYVYGLLPLP---------------------------- 517 PeVYIliLPaFGifSeiiPtFaRKpLFGYtsm..VyAtllItfLSfiVWl i++ ++ F +++++ + ++l LS +V+ NP_036459. 518 ------------IWYAVLREF--------QVIqdLVVSVLTYPLSHFVGY 547 HHMFTvGgpanvrkfFsitlTmlIAiPTGiKiFN...WlaTlwgsgRerg FT G+ v +fF ml A G+++F ++l+ lw r NP_036459. 548 LLAFTLGIEVLVLSFFYRY--MLTA---GLTAFAawpFLTRLWT----RA 588 GkGrirfttpMLfakleFSaliGFillFliGGiTGVmLAsaplDlvvH.. + ++ +t+ f+ ++LA++pl vv ++ NP_036459. 589 KMTSLSWTF---FS---------------------LLLAVFPLMPVVGrk 614 .nTyFVVgHFHyvlgggvvFglfAGlyYWfPKmtGrmln...EtLGk..i ++ + l++g+ + + +++ + +++r+ + +E L ++ + NP_036459. 615 pD---------ISLVMGAGLLVLLLSLCVVTSLMKRKDSfikEELLVhlL 655 hFwlwfIGfnLtFfpqhfLGLmGMPRRiatYlpnpewatlnvv...stiG + +++ +++ + q ++ l ++ +n++ + +t+ NP_036459. 656 QVLSTVLSMYVVYSTQ------------SSLLRKQGLPLMNQIiswATL- 692 Afllgigia..ifvynlfySlrkgkkvrvntgDPWgsg....rTLEWats A l + ++++ +++ S++ ++ +++ ++ +++ L + NP_036459. 693 ASSLVVPLLssPVLFQRLFSIL--LSLMST----YLLLstgyEALFPLVL 736 SPpppeynFaefpPrvreedafwdmkeeglaekkpalplyyqaihmPrns S + + + +++ + + ++ k++++ + + ++ + q+ +++ NP_036459. 737 SC-LMF-VWIN-IEQETLQQSGVCCKQKLTSIQFSYNTDITQFRQLYLDD 783 gspffisvglfva<-* ++++f v+++v NP_036459. 784 IRRAFFLVFFLVT 796 COG0619: domain 1 of 1, from 523 to 805: score -119.3, E = 80 *->mdsmniglyvprksssfltksflHrldPrvKliavillvvivflpsg ++ + +++ + lt + H + +++ + + i ++v++f++ NP_036459. 523 LREFQVIQDLVVSV---LTYPLSHFVGYLLAFTLGIEVLVLSFFYRY 566 lvtlliiflltlllvllsglpprfllllfrlvlllflfLllvngltyfdP +t ++ ++ + +l +l+ r+++ ++++++++l+ +++ P NP_036459. 567 MLTAGLTAFAAWP--FLTRLWTRAKMTSLSWTFFSLLLAVFPLM-----P 609 ......n.fllwtillFNyqdNalanknLnFillillftflgrsWtetpl ++++ +l+ + l l+ll+++ + +t l NP_036459. 610 vvgrkpDiSLVMGAGL-----------------LVLLLSLCV----VTSL 638 fqigpllvnspyvlteeglllgvlitlRilslvtlaflLtlTTsprelar + + ++ +l+ l ++++ l+++++ +T++ NP_036459. 639 MKRKDSFIKEE-----------LLVHLLQVLSTVLSMYVVYSTQSSL--- 674 glerLglPl..kllkipvheialllaLAlRyi..PlLleElqrimqAqrs l+++glPl + ++ ++l+ +L + ++++P+L++ l +i+ + +s NP_036459. 675 -LRKQGLPLmnQIIS----WATLASSLVVPLLssPVLFQRLFSILLSLMS 719 RgvdfgkgsflrrqRlrklgalvipLliralkkAEevalA.......Mea + + g ++ l+ l++ ++ + +++ E++++++ ++++ + NP_036459. 720 TYLLLSTG--YEA--LFPLVLSCLMFVWINIEQ-ETLQQSgvcckqkLTS 764 RGYtgnkkrtkyrtlkgvwrdiavlvllvllvlvlilflglkva<-* ++ n+ t++r+l+++ + +++ +++lv +f++ + a NP_036459. 765 IQFSYNTDITQFRQLYLDDIR---RAFFLVFFLVTAFFGTGNIA 805 COG1620: domain 1 of 1, from 473 to 806: score -462.6, E = 86 *->mlmWtQnYdPiGgnlwLsalvAliPIllfflaLvvlklkGyvAgpit ++ ++ + + +l ++vA+ Il+ f++L ++A p+t NP_036459. 473 VSKEV---KKPS-HLLPCSFVAIG-ILVAFFLL-------IQACPWT 507 llltvaiAlfyfkmPvemasaSvlyGflyGLwP.IawIIfgAvfLYklsv + yGL P ++w NP_036459. 508 YYV-------------------------YGLLPlPIW------------- 519 kSGafeiIRssilsIspDrRiQvlLIGFcFGaFLEGAAGFGtPvAItAaL ++R++ ++iQ l NP_036459. 520 ----YAVLREF-------QVIQDL-------------------------- 532 LVgLGFnPLyAAgLCLIaNtaPVAFGAVGIPIwvGtaaglvtgavkeAle +++ l t NP_036459. 533 -----------------------------------VVSVL-TY------- 539 asgdidaleIsamvgriLpivsllIPfllvflmdrFfGknrgwkgiketw ++ ++ +++L+i l+ f+ ++++ g++ + +w NP_036459. 540 ----PLSHFVGYLLAFTLGIEVLVLSFFYRYMLTA------GLT-AFAAW 578 Paal.......vAGlSFaipQfLtsnvLGPELP........sIlggLvsL P++ + ++ + ++lS + L++++ P P +++++ s++ g+ +L NP_036459. 579 PFLTrlwtrakMTSLSWTFFSLLLAVF--PLMPvvgrkpdiSLVMGA-GL 625 ailalfLKkwqpkpkfrwdgagqaanavstasegktllaplayrigkiik ++l l L + + k+ ++ + ++ + ++ ++++ NP_036459. 626 LVLLLSLCVVTSLMKRKDSFIK-------EELLVH-------LL--QVLS 659 awsPfllltavlvlwslpffKalf.lggalylkslnfsfpnilgevgkvq + + ++ + + l l++ ++s+ + NP_036459. 660 TVLSMYVV---------YSTQSSLlRKQGLPLMNQIISWATLAS------ 694 vlKspPIvaeatpisavfKllylpGliatatGTaIllAalisililkkik s+v ll +p l+ l sil++ ++ NP_036459. 695 --------------SLVVPLLSSP----------VLFQRLFSILLSL-MS 719 pkdaisafkeTlkelalPiltIgfvlafarlmnySGmsrsGlaSMpkttl +s+ e l l+l++l+ + + + + NP_036459. 720 TYLLLSTGYEALFPLVLSCLMFVWI------------N----------IE 747 alalalTGea....FpfFSPflGwLGvFlTGSdTsSNlLFGsLQfvtAqq ++l++ G +++ + s+Qf+ + NP_036459. 748 QETLQQSGVCckqkLT-------------------------SIQFSYNTD 772 iGlsptLlvAANtvGGvmGKMISpqsIaiAcAavGLvGkEgdLfRkTvkp i+ L + d +R+ NP_036459. 773 ITQFRQLYL--------------------------------DDIRR---- 786 sliyliivGvityliaylftgmipt<-* ++l++ ++ a++ tg+i++ NP_036459. 787 -AFFLVFF----LVTAFFGTGNIAS 806 COG2889: domain 1 of 1, from 483 to 814: score -184.4, E = 31 *->MIpliLglivgiitsltdlkaS.yidikhfiipvkitsKWWCkRKGC p i ++++ +++ a + ++ ++ p i NP_036459. 483 LLPCSFVAIGILVAFFLLIQACpWTYYVYGLLPLPIW---------- 519 EYEaKGPYiPIvelgillnlarglkgsnaiialspaigLvlilaiGYfLy a + ++ + +l + l ++ + ++ + vl l+ f y NP_036459. 520 --YAVLREFQVIQDLVVSVLTYPLSHFVGYLLAFTLGIEVLVLS---FFY 564 ytggwAgGDVklftAlsaLLPyqpslvkYsFLGtaPpyslYLplNpLtii + Ag +tA +a P+ l a sl+ + NP_036459. 565 RYMLTAG-----LTAFAA-WPFLTRLWTR-----AKMTSLSWTF------ 597 fnsIlaifPlilvYslvglaikgsaReLldlfkeglrqYRtvvvvtLwin f +la+fPl+ v g + +++ gl v + L + NP_036459. 598 FSLLLAVFPLMPVV--------GRKPDISLVMGAGLL----VLLLSLCV- 634 saviLaalVssflpir.kIikyliLtflLillfsrfkllvgdvigvvsIk V+s + ++ ik +L L ++s + +v+s NP_036459. 635 --------VTSLMKRKdSFIK-EELLVHLLQVLSTVL----SMYVVYSTQ 671 YgLYltgilyLseivllfvvIyalkLirslvkalrREvLiDekkVeELKe +L+ l L ++ ++ + L+ l++ vL ++ + L NP_036459. 672 SSLLRKQGLPLMNQIISWATLAS-SLVVPLLS---SPVLF-QRLFSILLS 716 GdiLgeriiltgDGvvrdrsdlldriktllrgEkvealkYRGEEvv.... L ++ l + G++ l + + + e l+ v +++ NP_036459. 717 ---LMSTYLLLSTGYEALFPLVLSCLMFVWINIEQETLQ--QSGVCckqk 761 gfsveGLteEqIekLKkLvseGKieDkflVrKamPFaPalfiGfLvslll ++s + +I + ++L+ + D +r+a+ +l+ fLv ++ NP_036459. 762 LTSIQFSYNTDITQFRQLY----LDD---IRRAF----FLVF-FLVTAFF 799 gdlaiiLvlkvdgla<-* g i + +d NP_036459. 800 GTGNIASINSFDLAS 814 COG0861: domain 1 of 1, from 481 to 815: score -182.1, E = 58 *->spllwlgFavvvavLllvDlgllrrkg.hvvtvkeaaiwsalwvils s ll +F ++ ++ l++ + + +v ++ + iw a+ + NP_036459. 481 SHLLPCSFVAIGILVAFFLLIQACPWTyYVYGLLPLPIWYAVLREFQ 527 flfsfmewwylvsiagrevlsdpeawlellTLilLEivLgiDNiiviAil ++ ++ + ++++ l+ ++++lL Lgi ++v++ NP_036459. 528 VIQDLVVS-------------VLTYPLSHFVGYLLAFTLGIE-VLVLSFF 563 vskLsVPpeqRkrAlflGL.agA...lvlRi........lLlfsGAaLis +++ l+ GL+a+A ++++R+ ++ + ++l+ + NP_036459. 564 YRYM----------LTAGLtAFAawpFLTRLwtrakmtsLSWTF------ 597 qisWllyLtqplllvtGiklafpkSgrDlilliGglfLlfkavkeWltee +s ll ++ pl v G k + l++++G l Ll ++ + + NP_036459. 598 -FSLLLAVF-PLMPVVGRKP-----DISLVMGAGLLVLLLSLCVV-TSLM 639 legekffeksndgkkkkkatpfwgviiqIellDivFSLDSViAAvamtqG + f++++ + ++++v+ ++ + +v S tq+ NP_036459. 640 KRKDSFIKEE----L---LVHLLQVLSTVLSMYVVYS----------TQS 672 ......................dlfv......vltaviiavlv.mrfask + ++++ + ++ + + + l v+ +++vl ++++l ++++ + NP_036459. 673 sllrkqglplmnqiiswatlasSLVVpllsspVLFQRLFSILLsLMSTYL 722 liadfvdrfptLkylaavfLgfIGvkLvleafhlhipalipkgk...... l++ + + L++ + L+f+ + + e++ + +k ++ + + NP_036459. 723 LLSTGYEALFPLVLSC---LMFVWINIEQETLQQSGVCCKQKLTsiqfsy 769 ...................felfylyaalaFavllsiellnirarknkkk +++ ++ ++ ++ ++ f +f+l +a + + i+++n ++ NP_036459. 770 ntditqfrqlylddirrafFLVFFLVTAFFGT--GNIASINSFDL----- 812 keg<-* ++ NP_036459. 813 ASV 815 COG3135: domain 1 of 1, from 410 to 816: score -396.5, E = 38 *->mmvDGAFvRAEEAvSLNRLPSPiSKNPAPAAHSDLRLStCRDALElA + +E vSL K A L D l NP_036459. 410 -----KHRKFDEVVSL-------CKELIHLALKGLSYYHTYDRFFLG 444 ifynvasvplf...slliirPsialrtgraSasrevLlPareriflarsd + v+ + sllii l g++ +ev P + + NP_036459. 445 VNVVIGFVGWIsyaSLLIIKSHSNLIKGVS---KEVKKPSHLLPCSFVAI 491 kvRvsFSlkRScsRqagklslVRlGCPGmLRdGeartlleittreprmRg + v F l qa + + +G + ++ +++ + + NP_036459. 492 GILVAFFLL----IQACPWTYYVYGLLPLPIWYAVLREFQVIQDLVVSVL 537 FaddtpPsaLlAGfvAvlvGGGRvPAPYassavliGLSDwqAaGFqaAGa p+s+ + ++A + G vl+ LS + AG+ NP_036459. 538 TY---PLSHFVGYLLAFTLG----------IEVLV-LSFFYRY-MLTAGL 572 spAQisSWLwal.......gvvmGvvgitLsLrYRvPivtAWSTPGaALL + ++ L+ l ++ + +++ +++L + +P+v NP_036459. 573 TAFAAWPFLTRLwtrakmtSLSWTFFSLLLAVFPLMPVV----------- 611 vaSlgglt.laEaiGA.FlVSaALitLcGvtapftRlmrkiPlsLAaALL g+ ++ + + GA++lV +L+ Lc vt + R + i L LL NP_036459. 612 ----GRKPdISLVMGAgLLV--LLLSLCVVTSLMKRKDSFIKEELLVHLL 655 AGiLLPFglkafaAleqqpaLvllmllsY.....LLakqfaPRYAVllaL q vl+m ++Y+++++LL kq NP_036459. 656 ----------------QVLSTVLSMYVVYstqssLLRKQ----------- 678 lVGVvvaallGqlhladlalkSLlavPewvtPeFSlaAlLslALPLfLvA ++ + a la l+vP P ++ l s+ L+ NP_036459. 679 ----GLPLMNQIISWATLASS--LVVPLLSSPVL-FQRLFSI-----LLS 716 mtSQnlPGiAvLkAaGYRqaPpsPLlvaTGlASllaAPfGshsvnLAAIs + S +l L + GY + PL+ ++ l++ + +n+ NP_036459. 717 LMSTYL-----LLSTGY--EALFPLVLSC----LMF-----VWINI---- 746 AAICmgPdaHpDkarRYtAalwAGiFYlLaGlFA.aallgLfaaLPapll + + G + + l+ + + NP_036459. 747 ---------EQETLQQ-------------SGVCCkQKLTSIQFSYNTDIT 774 amLAGLALLgsimgsLqnAlkdereReGRGAAqPGSLAAlvaFaVTaSGf + + d+ R lv F+VTa NP_036459. 775 QF--------------RQLYLDDIRRA----------FFLVFFLVTA--- 797 tLlgIGaAfWGLvaGlLaylvLnqiarRerg<-* ++g G +a ++ L+ + NP_036459. 798 -FFGTGN-----IAS-INSFDLA-----SVY 816 COG1994: domain 1 of 1, from 592 to 825: score -86.1, E = 66 *->MlslllikkmrvnmrlfrvsgrepldlhvsvlllLllfayvhelaha ls+ ++ ++++l+ v g ++ ++s++ ++l +++++l + NP_036459. 592 SLSWTFFSLLLAVFPLMPVVG---RKPDISLVMGAGLLVLLLSLCVV 635 yvasffWrikkvaalplgdrtllgagravgLflnpvaHelghgsygglae ++ + + d+++++ L++++++ + + s++ + NP_036459. 636 TS-----------LMKRKDSFIKE--E---LLVHLLQVLSTVLSMYVVYS 669 leigyyvapllglliksiflllfgfagPGivavlgrelktprlqellisl +++ +gl + + +++ +a +++v++l+ + r NP_036459. 670 TQS--SLLRKQGLPLMNQIISWATLASSLVVPLLSSPVLFQR-------- 709 AGPavNlaLAllflvvsrvllcvrlvvvalplgawLallnlaLaiFnlip +++++L+l++ ++ +++ al + l++++++i + NP_036459. 710 ---LFSILLSLMSTYLL-----LSTGYEALFPLVLSCLMFVWINIEQE-- 749 ilpndglav.....lnllpippldgskalkilapaGksvkvllalfgaea + +v +++l ++ + ++ +++ +l +++a++ NP_036459. 750 --TLQQSGVcckqkLTSIQFSYNTDITQFRQ--------LYLDDIRRAFF 789 ygiililvllflyigaevsqllrlleeaqlvslislflgv<-* + ++l+ +++ ++ +a ++ + +a + + + f + NP_036459. 790 LVFFLVTAFFGTGNIAS--IN--SFDLASVYCFLTVFSPF 825 COG0591: domain 1 of 1, from 438 to 829: score -234.8, E = 30 *->nliillifliYlvlvllIGwyayrrtksgseleDYylaGRslgpfvv +l + +++++v +I++ NP_036459. 438 YDRFFLGVNVVIGFVGWISYA-------------------------- 458 alslgatymSaatflGlpGaaYa..sGlgglwyaigyligalilallvap l+++ S ++ G++ + ++++ l+ + aig+l+++++l + + NP_036459. 459 SLLII-KSHS-NLIKGVSKEVKKpsHLLPCSFVAIGILVAFFLLIQACPW 506 rlrklsekknnalTipDflaaRfgskskllRilsalviivfflpYlaaQl + +++ NP_036459. 507 TYYVYG-------------------------------------------- 512 vGgglllevlf.idyetgivigalivilYtflGHGmkavawTDviQgilm l++++++++ +l ++viQ+++ NP_036459. 513 ---------LLpLPIWYA------------VLR-------EFQVIQDLVV 534 lvalivlpvvvllk.gGfgeafealaaalpl.alggsgmviaiis.iill v + l + G+ af+ ++l+l++++ ++ ++++++ NP_036459. 535 SVLTYP-----LSHfVGYLLAFTLGIEVLVLsFFYRY----MLTAgLTAF 575 lawgfGvlglPhilvRffaaksakelrlkailiggfwgilyllaaaliGl +aw f l+R+ + + l + +++ +++++ l++++ NP_036459. 576 AAWPF--------LTRLWTRAKMTSLSW--TFFSLLLAVFPLMPVVGRKP 615 aaialvgdgpaadmavglvpadnaqnnWsemvfpalivallppeALvwla ++ g+g + +++ +++++ + + NP_036459. 616 DISLVMGAG---------LLVLL-------LSLCVVTSLMKRK---DSFI 646 GfllaailAAimSTadsqLlvassaftrDiYkrvirkgknasekklvrvs l++ l ++ST v+s +++++ +++rk + ++ ++ NP_036459. 647 KEELLVHLLQVLST------VLSMYVVYSTQSSLLRK-QGLPLMNQ---- 685 RiavlllgvialllAllppgnpvvldlvglafgglgaaflpvl..llgLy ++ + l +l++p l ++l + ++ +l +l++ y NP_036459. 686 -----IISWATLASSLVVPL---------LSSPVLFQRLFSILlsLMSTY 721 WkRatkwgAiaGmiaGlltvil............................ +t + A+ + ++ +l++++ + ++++ ++++ +++ ++ + + ++ NP_036459. 722 LLLSTGYEALFPLVLSCLMFVWinieqetlqqsgvcckqkltsiqfsynt 771 ................yeivPglfvslvafllgswkakAafivvslltkv + ++ ++ ++ ++ +++v++l+ +++++ ++s+ + NP_036459. 772 ditqfrqlylddirraFFLVFFLVTAFFGT----------GNIASINSFD 811 vasefelkmpaaapvgtrvqdrfeaaakavpaak<-* +a v f ++++++++++ NP_036459. 812 ---------LAS------VY-CFLTVFSPFMMGA 829 COG2704: domain 1 of 1, from 520 to 832: score -401.4, E = 31 *->iiFssllemsimlllqliivLlclFiGARlGGIGlGlaGGlGvvILv + +++ +l++ ++ l+ F+G l + G+ v++L+ NP_036459. 520 YAVLREFQVIQDLVVSVLTYPLSHFVGYL-----LAFTLGIEVLVLS 561 fvfgvPlkPGkiPiDVmLIImAVvaAisamQaAGGLDYMvqiAEKiLRrN f+ + + A +A +a ++ ++ ++ NP_036459. 562 FFYR-------------YMLTAGLTAFAAWP------FLTRLWTRA---- 588 PKrITilAPfVTylLTiLaGTGHvVySilPVIa...dVAkkngIRPeRPl K ++ + T++ +La V+ ++PV+++++d+++ NP_036459. 589 -KMTSL---SWTFFSLLLA-----VFPLMPVVGrkpDISL---------- 619 SaAVVaSQiAItASPiSAAVVymsAvLeplgaFDgrhisYldLLmVtIPs V ++ + +S VV ++++ F + + + +LL+V s NP_036459. 620 ---VMGAGLLVLL--LSLCVV--TSLMKRKDSFIKEEL-LVHLLQVL--S 659 TllgcllaaffsnfrGdkeLddDPeYQeRLkdPlvkeyi.ygdtgtklek T +++ ++ + + L +++ Pl i+ ++ +++l + NP_036459. 660 T-----VLSMYVVYSTQSSL------LRKQGLPLMNQIIsWATLASSLVV 698 elpksAKlSvwiF..LgaivlVVlyAaaisirigligpGkPkvlgmdlaI l + S ++F++L++i+l l+ + +++g + P vl+ + NP_036459. 699 PLLS----SPVLFqrLFSILL-SLMSTYLLLSTGYEAL-FPLVLSCLMFV 742 qmfM....LsagaLIilltKtdpakIlngsVFKSGMtAcvavfGiAWLGD + ++++L ++ +K ++I+ + NP_036459. 743 WINIeqetLQQSGV---CCKQKLTSIQFS--------------------- 768 TfvsaHideiKevagelVkdyPWtlAvaLFlaSvLlnSQAATakALvPsv + i+++ + + ++ +++Fl+ ++ NP_036459. 769 --YNTDITQFRQLYLDDIRR---AFFLVFFLVTAF--------------F 799 alALGispantedllvlVAsfaAvsgyFvLPTYPtllAAvqfDdTGTTkI +++ +i+ + sf +lA+v NP_036459. 800 GTG-NIAS---------INSF--------------DLASV---------- 815 GKyvFNHSFfiPGllgValavafGfvlaslvi<-* y F l+V++ f ++l+ NP_036459. 816 --YCF---------LTVFSP----FMMGALMM 832 COG0168: domain 1 of 1, from 412 to 856: score -297.4, E = 47 *->mdlrtiarivGil..lqlfsllm.......lvPvlvalffeeglfvp +++ +++ + l +l+l +l++ ++ ++ ++ v v++ f ++ NP_036459. 412 RKFDEVVSLCKELihLALKGLSYyhtydrfFLGVNVVIGFVGWIS-- 456 ffatsalfllgvglllkrtlkearllpsrdgflifvlawligalllaL.. +a+ +++ ++ l + + ps+++ ++fv++ +++a +l ++ NP_036459. 457 -YASLLIIKSHSNLIKGVSKEV--KKPSHLLPCSFVAIGILVAFFLLIqa 503 .PfaltadlnltitdldlpggaflsfldALFeamSavTtTGLTVvdtves P++ ++ NP_036459. 504 cPWTYY----------------------------------------VYGL 513 lPksglfwrslLqwlGGlGiivlavailpllgkgigltqLylaeargpvk lP +++ a+l+ + ++ + NP_036459. 514 LP------------------LPIWYAVLREF---------QVIQDLV--- 533 dekilpslintaktiwliyllltllgallLwiagkpspgfdlmslfdaly + ++++l++++ +++++l++++l +++ + ++ NP_036459. 534 VSVLTYPLSHFVGYLLAFTLGIEVLVLSFFYRYM--------LTAGL--- 572 qAifHs............mSafsnGGFSthdwnssigyygspiaielvti f + + ++ ++ +m+ +s +FS+ + + + ++ NP_036459. 573 -TAFAAwpfltrlwtrakMTSLSWTFFSLLL--AVFPLMPVV-GRKPDIS 618 ilmIlGGigFpvhydllrglkkkiKkGnrrslfslftdlqtrtag..... ++m +G ++ ++ + + + l k+ K + ++ + ++ ++ t ++ NP_036459. 619 LVMGAGLLVLLLSLCVVTSLMKR-KDSFIKEELLVHLLQVLSTVLsmyvv 667 ......................ffvllillstilaaiqlalektnpyalq +++++ ++++ + ++ + +++ l++ +l+ + ++ +++ NP_036459. 668 ystqssllrkqglplmnqiiswATLASSLVVPLLS---SPVLFQRLFS-- 712 qlganlsshdrllaslprialffqvsasrtaGFstadignwsdaslvlll +l s + + ++G+ + + l+ NP_036459. 713 -----------ILLS------LMSTYLLLSTGYEAL--------FPLVLS 737 llMfIGgsaGSTaGGIKtiRfavllkalkseirg....lihPksavfkrk +lMf + +++ + + g +++ ++ + + NP_036459. 738 CLMF----------------VWINIEQETLQQSGvcckQKLTS---IQFS 768 iggrtlskaeaqEiieav.lvfflllvllavvllllleavgkydfldllF ++ + + + q ++++++ +ffl+++l+++++ + +a + ++ +dl NP_036459. 769 YNTDITQFR--QLYLDDIrRAFFLVFFLVTAFFGTGNIA-S-INSFDL-- 812 EvvSAfgtVGLSlGiTstelslfanlpvlaKliliilMfiGRLeiltvlv ++v +f +T +++ ++ ++M+ il +v NP_036459. 813 ASVYCF--------LTV----FSP------FMMGALMMWK----ILIPFV 840 lfvrkpkdllwkypreedvl<-* l+ +++ + + NP_036459. 841 LVMC----AFEAVQLTTQLS 856 COG1113: domain 1 of 1, from 533 to 857: score -423.9, E = 44 *->MdpslvmaddnqdaeqeLkRgLknRHIqlIAlGGAIGTGLFlGSgsa +++v + + NP_036459. 533 --VVSVLTYPLSH---------------------------------- 543 IqmAGPsvlLaYaIaGlivflIMRaLGEMavanPvaGSFsdYArkylGpw +++Y++a +++ I E +v NP_036459. 544 --------FVGYLLA--FTLGI-----EVLVLS----------------- 561 AGFltGWlYWflWvlvgmaElTAvgiYmqyWfpaFPdvPqWiwALialvl ++ ++l+++ lTA+++ W p ++ l NP_036459. 562 --------FFYRYMLTAG--LTAFAA----W-P------------FLTRL 584 llavNLisVKlFGElEFWFAlIKVaAIvafIvlGlvllfggfggggtGfs + + ++s + + ++++++ + l+ ++ + + +s NP_036459. 585 WTRAKMTSLSW--------------TFFSLLLAVFPLMPVVGRKPD--IS 618 NLwahtGGFFPnGllGlllalqvvvFAFgGiElvGitAgEakdPeksipk + + Gll lll+l+vv +s+ k NP_036459. 619 LVMGA-------GLLVLLLSLCVV---------------------TSLMK 640 AinsVi...wRIliFYvGslfvilslyPWnqvgsggsgSPFVtvFskiGi s i++++ + + v+s ++ + ++ + ++ + ++k G+ NP_036459. 641 RKDSFIkeeLLVHLLQVLSTVLSMYVV----YSTQS------SLLRKQGL 680 paAasImNfVVLTAAlSslNSGlYstsRMLysLAeqGdAPkffaklsrrG p +I+ L +Ssl+ l s+ P +f + NP_036459. 681 PLMNQIISWATL---ASSLVVPLLSS-------------PVLFQR----- 709 VPvnAillsavvlllgVlLNYvaPsvekvFelltsssglgalfvWlmI.. l+s++ l +++L + +e l ++ +++fvW+ I++ NP_036459. 710 ------LFSILLSLMSTYLLLSTG-----YEALFPLVLSCLMFVWINIeq 748 .......llsqLkfRkarkpaqgaalkFk............mpLyPftty ++ +++++++ k+ + +++ ++F++ ++ ++ + ++ +t NP_036459. 749 etlqqsgVCCKQKLTSIQFSYNTDITQFRqlylddirraffLVFFLVTAF 798 ltlaFllfv....LvlMafdpdtRislfvtpiwlvlLvigYlvfgkrrka ++ ++ +++ +L ++ + + + +++ + ++i + +++ a NP_036459. 799 FGTGNIASInsfdLASVYCFLTVFSPFMMGALMMWKILIPFVLVMCAFEA 848 eahgarpvkaee<-* + ++ ++ NP_036459. 849 VQLTT---QLSS 857 COG3152: domain 1 of 1, from 773 to 857: score -67.1, E = 29 *->meWYLkvlKqlYFsFnGRigRkeyWmfilvniiitlvlvslegllge + + +qlY + i+R ++ f lv + +++ + ++ +++ NP_036459. 773 ITQF----RQLYLD---DIRRAFFLVFFLVTA--FFGTGNIASINSF 810 dvahGevllaalyslavllPalAitvrRLHDtdrSGWW.aLLfvvPfiGw d+a + + l v+ P + G++ ++ ++Pf++ NP_036459. 811 DLA------SVYCFLTVFSPFMM------------GALmMWKILIPFVL- 841 atipAillaVNTQPvmlealirFValLilvliLIyllvlpGtsGeNRYGp ++ +++ + NP_036459. 842 ----------------------------------VMCAFEAVQ------L 851 dPklis<-* ++l s NP_036459. 852 TTQLSS 857 COG1138: domain 1 of 1, from 448 to 858: score -417.4, E = 15 *->MlpelGnflLllAlllalllsllplvGasrrdaklmanniCLKFFPW + ++G ++ +A ll + + ++ G+s+ +k NP_036459. 448 VIGFVGWIS--YASLLIIKSHSNLIKGVSKEVKKPSH---------- 482 iPCtsqvmlArpaayaqflllalAfllLvyaFltdDFSVqYVAaNSnseL ++ ++++A++ Lv+ Fl+ + NP_036459. 483 ----------------LLPCSFVAIGILVAFFLL------------IQAC 504 PlyYKisAvWggHEGSLLLWvllLslwtflvalfsrklpdtlkarvLAVm P+ Y + + +l L +w +a + + +++ v +V+ NP_036459. 505 PWTYYVYG------------LLPLPIW---YAVLREF--QVIQDLVVSVL 537 gLivlgFllfilftSNPFtrllPavPieGrdLNPlLQdvgLIfHPPLLYl + ++ F++ +l +Ft + +v NP_036459. 538 TYPLSHFVGYLL----AFTLGI-EVL------------------------ 558 GYVGfaVaFafavAslLgGrldsawaRwsRpWtlvaWlFLTlGIvLGSWW V +++ + + + + L+ + +aW FLT NP_036459. 559 --V-LSFFYRYMLTAGLT--------------AFAAWPFLTR-------- 583 AYyELGWGGwWFWDPVENASLmPWLagtALlHSlavTeKRgsFkhWTvLL L + A + Sl+ + F + +LL NP_036459. 584 ------------------------LWTRAKMTSLSW---T--FFS--LLL 602 AilAFsLvLLGTFLVRSGvlvSVHAFAsdpvRGvflLaflvlliggSLlL A++ ++ v+ + p +++++++g L L NP_036459. 603 AVFPLMPVV-----------------GRKPD-------ISLVMGAGLLVL 628 falRapqvrEktisrlfdawsrvnfellSrEgllLlnNillvvallvVll + + ++ + ++++++ E+l l+ +l +v V+ NP_036459. 629 LLSLCVVTS----L------MKRKDSFIKEELLVHLLQVLSTVLSMYVVY 668 GTLyPlvvkllglgsQPPSisvGePFFnklFipLmlpllallGvGplvRW +T +++l + +G+P n ++W NP_036459. 669 ST-------QSSLLR-----KQGLPLMN-----------------QIISW 689 kraqpstlatLimLlviliaslVlaallifllgdtvnlasaLglaaaawv tl L+v l+ s Vl f+ +l s+L+++++ + NP_036459. 690 -----ATL--ASSLVVPLLSSPVL-----FQ-----RLFSILLSLMSTYL 722 lLlllaellwrtrgrvflvGkrkltrSqwgmiLaHlGvaliaiGiamSgl lL + +e+l+ + l +++++ ++ NP_036459. 723 LLSTGYEALFPLV----------------------LSCLMFVWINIEQET 750 yssNQGYSEErdVrLaGEVSVpGqtvtlggytftfqqlkeeqgpNytsev ++ + +V + + l ++ f + NP_036459. 751 LQ-------QSGVCCK---------QKLTSIQFSYN-------------- 770 AivdltregkNmmDEpiatLiPEkRfYvvegqsDrmteaaIdggllrDlY t+ ++ ++ ++ ++++ + + + + NP_036459. 771 -----TDITQ----------FRQLYLDDIRRAF-FLVFFLVTAFFGTGNI 804 valgeslrgngswAvrlyykgPlvrWIWaGGEGlLM...alGglLavtdd +++ +++ + + ++ + P++ G +l+M + ++ ++L + + NP_036459. 805 ASINSFD-LASVYCFLTVFS-PFM----MG--ALMMwkiLIPFVLVMCAF 846 rryrveveakkr<-* + ++ + + NP_036459. 847 EAVQLTTQLSSK 858 COG0772: domain 1 of 1, from 523 to 862: score -250.5, E = 37 *->rklkqrrhltDrlLllllllLllliGlvmvySassavladrsgngdp ++ +q ++ D+ + +l+ L +G+++ ++ +++vl+ + NP_036459. 523 LREFQVIQ--DLVVSVLTYPLSHFVGYLLAFTLGIEVLV---LS--- 561 hfffirQlvylilGlilmflllriplrklflkkwspllylvsllLLvlVl ff+r ++ ++l ++++ +l + ++ + +s+ ++ + l+ l+ NP_036459. 562 --FFYRYMLTAGLTAFAAWPFLTRLWTRAKMTSLSWTFFSLLLAVFPLMP 609 ffGvglapevnGAkRWirlG.ggfsiQPSEfvKlalilfLAyyLsrkqel ++G+ + p + + +G g++ + l+ +++ ++ rk+ NP_036459. 610 VVGR-K-PDIS-----LVMGaGLLVL-------LLSLCVVTSLMKRKD-- 643 lslppvllrslfrg..........................lrtflkpllv s+++ + + + ++ + +++++ lr+ +pl+ NP_036459. 644 ---------SFIKEellvhllqvlstvlsmyvvystqsslLRKQGLPLMN 684 vvipalLIllQPDLGTavvlliiglfmlFlaGvplrlvlaifillillal +i ++ ++ ++v+ ++ +lF +l+ ill+l+ + NP_036459. 685 QIISWATLAS------SLVVPLLSSPVLF---QRLF-----SILLSLMST 720 lilifvpfiiifsggsfllkpYqkk.RvtsfLdPeaDpl........... +l +++ + p ++ + ++++ e+ l++++ +++ NP_036459. 721 YLLLSTG--YEAL------FPLVLScLMFVWINIEQETLqqsgvcckqkl 762 ...GsGYQiiQSliAIGsGGlfGkGlgnGtqsKlgyLPEahTDFIFAvig ++ ++Y+ + + +q l+ + a NP_036459. 763 tsiQFSYNTD---------------ITQFRQLYLDDIRRA---------- 787 EEfGfiGvlllLaLffllilrglrIalrAlaatdlFgkllAsGitlliff ++l+++L ++ +g + ++ + dl + + + l +f NP_036459. 788 -------FFLVFFLVTAFFGTGNIASIN---SFDLASVY----CFLTVFS 823 QvfvNiGmvsGLLPvtGvpLPfiSYGGSSllstmiaiGiLlnisresRah +++ m+ +L +p+ ++ m+a+ + NP_036459. 824 PFMMGALMMWKIL----IPFVLV----------MCAF---EAVQ-----L 851 ryrvmrlgkke<-* ++++ ++ + NP_036459. 852 TTQLSSKSLFL 862 COG0201: domain 1 of 1, from 464 to 867: score -324.5, E = 17 *->mgvkdklkpmferlpavfrpkkgghveLrrKllfTllaLilYRiGsf ++ ++k + + +v++p +L + +++L+ ++ +++ NP_036459. 464 KSHSNLIKGVSK---EVKKPS-----HLLPCSFVAIGILVAFFLLIQ 502 .............IPvPGinaaalsdffeqqrg.ifgl.fNmFsGGalsr + + + ++P+++ +++ ++++ + +++ ++++ F G l NP_036459. 503 acpwtyyvygllpLPIWYAVLRE-FQVIQDLVVsVLTYpLSHFVGYLLA- 550 fSifaLGImPYITASIImQLLvgDviPsLikLdkenGeeGRrKiqqyTRy f+LGI Lv + + + ++ G + +TR+ NP_036459. 551 ---FTLGI----------EVLVL---SFFYRYMLTAGLTAFAAWPFLTRL 584 lTivlalvQAlgvalglnnlvg.sgpIssavaigpgpsggvvpvlfylli T a + +l+++++ l + + + ++g +p + l+ NP_036459. 585 WT--RAKMTSLSWTFFSLLLAVfP----LMPVVGRKPD-------ISLV- 620 ilqLtaGtmllmWLGEqItkGrGIGNGISL......iIfAGIvaglPsai +++++l+++L + SL ++++++I + l + + NP_036459. 621 ----MGAGLLVLLLSLCVVT--------SLmkrkdsFIKEELLVHLLQVL 658 fntielnngtesgpaGalprfiqgivql.spnkdllggsvvaFllnilsl ++ + +++++++++ + l +l++ NP_036459. 659 STVLS------------M-YVVYSTQSSlLRKQGL-----------PLMN 684 llivlatlaiivgVVYveqarRrIPIqYArRqqgvvGRrlyggGqstyLP +i atla ++V + + P+ R + l styL NP_036459. 685 QIISWATLASSLVVPLLSS-----PVLF-QRLFS----ILLSL-MSTYL- 722 iKlNyAGVIPvIFAiLlSalllfPstlaqffgsesPLargipiLGtyngp + + ++F l ++++ + + + NP_036459. 723 ---LLSTGYEALFP---LVLSCLMFVWINIEQE--------------TLQ 752 avglg..........gllyyiapylslsawildpldpwqqpgqpvYlaly + g + +++ ++ + + + i+++++l++ + ++ +++l+++ NP_036459. 753 QSGVCckqkltsiqfSYNTDITQFRQLYLDD---------IRRAFFLVFF 793 vvlIifFtyFYteiqGfnPreiAenLkKsGgfIPGiRpdGkqTekyLerv +v+ +f t i+ +n+ + A+ v NP_036459. 794 LVTAFFGT---GNIASINSFDLAS-------------------------V 815 ipRlTliGalfLgviAvlPellgalggvpnnvsfyfGGTslLIvVGVald lT+++ P ++gal+ ++ +LI + ++ NP_036459. 816 YCFLTVFS----------PFMMGALM-MWK----------ILIPFVLVMC 844 tmeqIe..aellsrqYeglrrlkkgglk<-* e+++ +++l s ++l ++ + + NP_036459. 845 AFEAVQltTQLSS---KSL--FLIVLVI 867 COG3366: domain 1 of 1, from 610 to 868: score -176.8, E = 70 *->vvdyidkvikammltlaylikilpivliGifiasiiietNilkKlkk vv k ++ + + l +++ s+ + t ++k+ NP_036459. 610 VVG--RKPDISLVMGAGLL----------VLLLSLCVVTSLMKRKDS 644 ilkpilrklnlpEec.visiatcFvsPTvGysMLkefy.KegkvnerEvi ++k l+ l +++v s+ + v +T ++ + k++++ + + +++ NP_036459. 645 FIKEELLVHLLQVLStVLSMYV--VYSTQSSLLRKQGLpLMNQIISWATL 692 vaslinsF...psvlshSvftfylPvlvpiLGyflGviYVlirvlVglik ++sl+ ++ ++p ++ +f +l ++ + L + +G +l NP_036459. 693 ASSLVVPLlssPVLFQR-LFSILLSLMSTYLLLSTG--------YEALFP 733 tlIGvLylkivlknrdieidsDAGVTmPnsdlkiksnrevvikAfkkTik + + L+ + + ++ s GV +i + + i+ ++ NP_036459. 734 LVLSCLMFVWINIEQETLQQS--GVCCKQKLTSIQFSYNTDIT----QFR 777 ilkrvipsivivvllvvFLielGlfDyveefakpltnvLnLsgeavtvai +l + +i + lv FL v++f++ g++ + NP_036459. 778 QL--YLDDIRRAFFLVFFL--------VTAFFG--------TGNIASINS 809 TelanisaAivtaagfldeGILsekevligLllGniiSfstrylKhSiPl la + + ++f + K +iP+ NP_036459. 810 FDLASVYCFLTVFSPFMMGA--------------------LMMWKILIPF 839 yiSLFGakfGlKlvmvNiavtvlldilfIalLLll<-* + + + +v + + ++lf ++L + NP_036459. 840 VLVMCAF------EAVQLTTQLSSKSLFLIVLVIS 868 COG2211: domain 1 of 1, from 455 to 872: score -374.9, E = 95 *->mgtertemskikeqsessekLsmkEKigYGfGDfasniifdivmlYL + + + k++s ++ s K s++ NP_036459. 455 ISYASLLII--KSHSNLIKGVSKEVK-------KPSHL--------- 483 LfFYTDVaGlpAalaGTlFLVaRifDAitDPimGllvDsRtnsGRwGKFR lp ++++ LVa ++ l+ +w NP_036459. 484 ---------LPCSFVAIGILVAFFL---------LIQA----C-PWT--- 507 PflLfGaiPfailavLc..FWltPdFsdtRLtNqWGKliYAyvtYmllGL + +G +P+ i + +++F ++ d+ + l+Y ++++ L NP_036459. 508 -YYVYGLLPLPIWYAVLreFQVIQDLVVS-------VLTYPLSHFVGYLL 549 tYtlvNiPYgALtpaiTqnpnERtsLtswRfilAtlGlllsavlflPlvn +tl E+ +L+ + + t+G l+a+++ P+++ NP_036459. 550 AFTL---------------GIEVLVLSFFYRYMLTAG--LTAFAAWPFLT 582 liggdpGdeqvGeyqvamlvLsivGivlliiCfrttKEryiLSPSLRRRL + + +++ + ++ l+L+++ ++ + K ++ NP_036459. 583 RLWTRAKMTSLS-WTFFSLLLAVFPLMPVV----GRKPDIS--------- 618 APLLmAAGitLiLLAiAKSFNLLGGSGFDYiSFFLiLLGLiWGGFGFtLR L+m AG+ ++LL + NP_036459. 619 --LVMGAGLLVLLLSLC--------------------------------- 633 DSAVEEHLqKvenqpskeveklsllkslklifkNrpLliLcimaLcsllA v ++ k k s+ k Ll+ ++ L + l+ NP_036459. 634 ----------VVTSLMK--RKDSFIK--------EELLVHLLQVLSTVLS 663 fniklailvYYvtYvLgdpeLfsymlllasgaaligsllliPrlvkrlGK + vY +++ L ++ ++ m+ ++s a+l + +l++P l+ NP_036459. 664 MYV-----VYSTQSSLLRKQGLPLMNQIISWATLAS-SLVVPLLSSPVLF 707 KkvfligllLwvlgdGvLLllffvpysnvvlifilaiiagvGtav..... ++f i lL++ + ll+ ++y++++ ++l+++ +v +++++++ NP_036459. 708 QRLFSI--LLSLMST---YLLLSTGYEALFP-LVLSCLMFVWINIeqetl 751 ..........vntlqWalvsDtVDY.GEwktGkRlEGlvYslftFfrKlG ++++ +++++++q + D+ + + +R+ ++f+ f+ + NP_036459. 752 qqsgvcckqkLTSIQFSYNTDITQFrQLYLDDIRR-----AFFLVFFLVT 796 lALg....GflpGimLgiiGYiARiPGVpNqaQtdaaLmGIraliaivPa + +g+++ +++ + L+ + Y ++ ++ ++ +++P NP_036459. 797 AFFGtgniASINSFDLASV-Y------CFLTVFSPFMMGALMMWKILIPF 839 fflllalIligrFYpLTekrykrIveeLeqRkrKvepvhakvqqqaisDv ++ + a+ + LT+ +L ++ + isD+ NP_036459. 840 VLVMCAFEAVQ----LTT--------QLSSKS-------LFLIVLVISDI 870 ka<-* a NP_036459. 871 MA 872 COG2056: domain 1 of 1, from 620 to 875: score -417.4, E = 51 *->MlenllmNaVViaVivMlVLSLlRVNVvLALiigAlvaGlvggLgLt V a ++ l+LSL+ Vv +L + NP_036459. 620 ---------VMGAGLLVLLLSLC---VVTSL------------MKRK 642 eTinafisGLgGnAtvALSYAlLGAFAvAIsKSGltdvlvkkvirllgkG +++ ++ + v L l + + +S ++l k + l++ NP_036459. 643 DSF------IKEELLVHLLQVLSTVLSMYVVYSTQSSLLRKQGLPLMNQ- 685 mhdeeargktlkKyllllvIlliAcfSQNviPVHIAFIPiLIPPLLs... ++ + A++ L+ PLLs++ NP_036459. 686 ----------------IISWATLASS--------------LVVPLLSspv 705 lFNkLkiDRRlVACvLTFGLtAPYilLPVGFGlIFqnsILldNlhqaang lF +L ++ L +Y+lL G+ ++F + l+ l NP_036459. 706 LFQRLF--------SILLSLMSTYLLLSTGYEALFP--LVLSCL------ 739 lsvsinvaqvplAMliPalGMvvGLLlAvfvtYRKPReYqekeqieeaet + v in++q ++ + + L +++ + +Y+++ i+ ++ NP_036459. 740 MFVWINIEQ--ETLQQSGVCCKQKL-TSIQF------SYNTD--IT--QF 776 edleanyenrefksiavaltLvaIVvaLvvQLySltdSmilGALlGlivf +l + +r+f+ ++ +l V a+ +t++ + + f NP_036459. 777 RQLYLDDIRRAFF-LVFFL-----VTAF---F--GTGNI-----ASINSF 810 flsGvvkfketddvfteGvKMM..AfIGFVMLvAaGFAeVlkaTGaVedL l v f + + f G MM + I FV V+ a aV+ NP_036459. 811 DLASVYCFLTVFSPFMMGALMMwkILIPFVL--------VMCAFEAVQLT 852 VnsvsssiGqsKgLaALLMLvVGLlITMGIGSSFsTIPIIAtiYVPLCla + +s s+ +L++L+ NP_036459. 853 TQLSSKSL----FLIVLVI------------------------------- 867 LGFSPlATiaiiGtAgALGDAGSPASDSTLGPTsGLNADGQHdHIwDTcV SD NP_036459. 868 -------------------------SD----------------------- 869 PTFiHYNiPLlVFGwIAAMvL<-* I A+ NP_036459. 870 ---------------IMALHF 875 COG0387: domain 1 of 1, from 530 to 879: score -269.2, E = 80 *->mDAttPLLtvAnsHPARnPkHtAWRasvadiavkLkskiffllLpfl D +Lt sH v + + + + l +f NP_036459. 530 QDLVVSVLTYPLSHFVGYLLAFTLGIEVLVLSFFYRYMLTAGLTAFA 576 v..pvsLllwwsfqtgpvviFiNLlallaIipLAayvgrAtEsiAarvGe + +++ l++ + t+ +++F+ lla pL vgr + i+ + G NP_036459. 577 AwpFLTRLWTRAKMTSLSWTFF--SLLLAVFPLMPVVGRKPD-ISLVMGA 623 piGgLlNAtFgnavEliLiiiaLksGGDdaatlVratltGSIlgnlLLvl + Ll+++ +++ ++k + ++ l+ +l +l v NP_036459. 624 GLLVLLLSLCVVTS-------LMKRK----DSFIKEELLVHLLQVLSTV- 661 GLSlllGglkyktQ..kFNphgAgqnsslLillaiia..LliPaaldeiy LS+ + y tQ+++ +g +++ + ++a++L++P +l NP_036459. 662 -LSMYV---VYSTQssLLRKQGLPLMNQIISWA-TLAssLVVP-LL---- 701 GGysetfatGaedrDCTFSHPPLKFNRlitelsqgLSiavAi.VlialYv s+++ + F l++ s+ L+++++ ++l+ l + NP_036459. 702 --SSPVLFQ--RL-----------FSILLSLMSTYLLLSTGYeALFPLVL 736 lfLyfqLvTHrklfdlDDglfeleeedgsaeddeeeepPshsaslwvwls L f ++ + e+++ + + +s NP_036459. 737 SCLMF--------------VWINIEQETLQQSGVCCKQKLTSIQF----- 767 tgvLLvaTvlvaiiaeiLvgsleavleslGSlsplFiGviVlalVgNaaE ++ ++i l+++ +F ++V+ lV a NP_036459. 768 -----------SYNTDI-TQFRQLYLDDIR---RAF--FLVFFLVT--AF 798 hlsAikvArkgkmdlAmniavGSaLQvallta..PvL..VLiSiFYTwmi + ++ ++ ++ + +a+ + ++lt+ +P++ ++L w i NP_036459. 799 FGTGNIASIN-----SFDLASVY----CFLTVfsPFMmgALMM----WKI 835 gkpMqLvfGqmFPLVFsafElValva..aVvlvnylssdGesNwLeGvll p Lv F a +l + +++++++l ++++sd NP_036459. 836 LIPFVLVMC-----AFEAVQLTTQLSskSLFLIVLVISD----------- 869 LalYaiialaFFfvgPRGEEGAPAALYAPAPaLv<-* i+al FFf+ v NP_036459. 870 -----IMALHFFFL-------------------V 879 COG0814: domain 1 of 1, from 293 to 879: score -298.8, E = 9.1 *->Skn.rk.h.VdaIsrvLnRsSfS.dlsa.dvdsD.fkTrrdSi.dd. + + + da R + + l +++ d + +T + + + NP_036459. 293 PQRvSAqQfDDAF-LKEWRLENWkRLDVnQADIApLMTSLIGVpFPl 338 .svydfkln.Ls.satsrRPnSeRki.lsadn.klas.sslnetsdad.e +sv+ ++ L + ++ +++ + + k+ + +t + NP_036459. 339 nSVGILPVDyLNnTDLFKAESMFTNAvQILEQfKVKMtQKKEVTLPFLfT 388 a..lA.dGRr.svldagrdri.fadnir.qs.assnid.edd....egsl + +l +d + l r i+++ ++ +s + i+ ++++ + + NP_036459. 389 PfkLLsDSKQfNILRKARSYIkHRKFDEvVSlCKELIHlALKglsyYHTY 438 trNfieflylilhf.agelletdiedeerqeenedeimedmsrqmvskvl r f++ + +i++ + +++ + i ++ s ++ v+ NP_036459. 439 DRFFLGVNVVIGFVgWISYASL-------------LIIKSHSNLIKG-VS 474 gslkwtssdlggvlilaGTaIGAGvLalPiaagggGfwplllmlvlawpl ++ k++s++ lP ++ +G+++ ++l+ a+p NP_036459. 475 KEVKKPSHL------------------LPCSFVAIGILVAFFLLIQACPW 506 tylsgllllevllsspnprngasfttlveeylGkkggilitllyafalyg ty+ ++ll ++ + r +++lv + l + + l+af l + NP_036459. 507 TYYV-YGLLPLPIWYAVLREFQVIQDLVVSVLTYPLSHFVGYLLAFTLGI 555 lllAYivgiGnilpsflgnqfg...............lsrtlgsllfvli +l+ + + l++ l+ + + ++ ++ + ++ls t++sll++++ NP_036459. 556 EVLVLSFFYRYMLTAGLTAFAAwpfltrlwtrakmtsLSWTFFSLLLAVF 605 lapvvllgtkavdkissllvfglvaillvlvlylipkwntallftvpldt v+ ++ ++ ++++ +++l+++l+v+ +++ k+++ + + NP_036459. 606 PLMPVVGRKPDISLVMGAGLLVLLLSLCVVTSLMKRKDSFIKEELLV--- 652 mlqtggqsylkylllaiPvivFsFggfhgiipslnsyydkeykritidfa + v+++ + + +++ s ++k + NP_036459. 653 -HLLQ-------------VLSTVLS-MYVVYSTQSSLLRKQ-G------- 679 vrkailigtlialilyalwgffvfGnllrlefaellaakgqnisllsala +++ +i++ ++l++ ++++++ +l++ ++lls+++ NP_036459. 680 LPLMNQIISWATLASSLVVPLLSSPVLFQR----------LFSILLSLMS 719 nffnsph...............illsyalnlFp.env..s.AllAilntS + ++ +++ + + + ++ + ++ + v ++ l i NP_036459. 720 TYLLLSTgyealfplvlsclmfVWINIEQETLQqSGVccKqKLTSIQ--- 766 FlGvyLGlfegladlfkksgla.dnskkgrkktrlltflpplifallypw f + d++++ l+ d+ + + + +++l++ ++ + + ++ NP_036459. 767 --------FSYNTDITQFRQLYlDDIRRAFFLVFFLVTAFFGTGNIASIN 808 alqgfayalgyaGalaatiiapIiPilLflkpryafykvipalrvfggnk +f+ a y l+ + +++++l+ +k + f +v a+ NP_036459. 809 ---SFDLASVYCF-LTV-FSPFMMGALMMWKILIPFVLVMCAFEAVQLTT 853 kfalllvllfGilvilasilsllgll<-* +++ ++l+ +++ ++ l+ ++l+ NP_036459. 854 QLSSKSLFLIVLVISDIMALHFFFLV 879 COG0730: domain 1 of 1, from 578 to 884: score -82.8, E = 0.6 *->mmnlalllllflvGfiaGflaglfGiGGGlllvPaLlflgg..lpph + l l + ++ + ++ ++l ll+v L+ + g++++++ NP_036459. 578 WPFLTRLWTRAKMTSLSWTFFSL------LLAVFPLMPVVGrkPDIS 618 vAvGTsllqvlftalssayahlkkgnvdlklglilglgsvvGaalGalla ++ G++ll+ l++ l + + +k++ +k l+ l v++ +l +++ NP_036459. 619 LVMGAGLLVLLLS-LCVVTSLMKRKDSFIKEELLVHLLQVLSTVLSMYVV 667 klipaeiky............................eaLklifglllll + + +++ + ++ + + ++ + +++++++ +f +ll l NP_036459. 668 YSTQSSLLRkqglplmnqiiswatlasslvvpllsspVLFQRLFSILLSL 717 lalymllskkiei....................................k ++ y+lls e+ + + + ++++ ++++ +++ ++ ++ NP_036459. 718 MSTYLLLSTGYEAlfplvlsclmfvwinieqetlqqsgvcckqkltsiqF 767 pkreekpnkkslplpglggfyepleieyavrawlliliGfliGflsGllG ++ + + ++l+l+ +++ NP_036459. 768 SYNTDITQFRQLYLDDIRR------------------------------- 786 iGGGsllvPaLilllgyslplkkavgtsllaialsslisfllyllggpvd + +l+ ++ + ++g ++++ ++ la l+ f +++g + NP_036459. 787 --AFFLVFFLVTAFFG--TGNIASINSFDLASVYCFLTVFSPFMMGALMM 832 wllalglvlGsiiGaylGarlasrkligprflrllfalilllvalklllk w++++++vl a+ ++ l++ ++++ l l++++i ++al ++ NP_036459. 833 WKILIPFVLV--MCAFEAVQLTTQ--LSSKSLFLIVLVISDIMALHFFFL 878 glgmll<-* + NP_036459. 879 VKDYGS 884 COG0534: domain 1 of 1, from 520 to 892: score -254.2, E = 26 *->gsirkaLlkralrLAiPiilanllqtlyglvDtfmvGhlgGadaLAA + +++ + ++ l+++++++ + +vG+l+ a L+ NP_036459. 520 YAVLREFQV----------IQDLVVSVLTYPLSHFVGYLL-AFTLGI 555 VglaspilflliaigmglgtGtsvlvaQaiGAgdregarraarqglvlla l+ ++++ ++++++ + ++ ++ +++ +a+ + + ++ + NP_036459. 556 EVLVLSFFYRYMLTAGLTAFAAWPFLTRLWT-----RAKMTSLSWTFF-S 599 lllslllgllglfllellLrllgaseevlalAaeYLrililglpfallsf lll+++ + +++ +++g a L l+ ++ l NP_036459. 600 LLLAVFPLMPVVGRKPDISLVMG---------AGLLVLLLSLCVVTSLMK 640 vlrgalrgaGdtrtpmvvsiignllNivLdyiLIfGkgvlFGfpglGivG ++++ + +L++ ++ NP_036459. 641 RKDSFIKEE----------------------LLVHL-------LQV---- 657 AAiATviarwigflvllfyllrgkkgllislfdrvlkllkpdrkvlkkll ++Tv+++++ ++ l +k+gl++ + + +++++l + l NP_036459. 658 --LSTVLSMYV--VYSTQSSLLRKQGLPLMNQ------I-ISWATLASSL 696 rlG.f.lPialeeilfsvgsfllntlfvarfGtdavAAyqialriaslif + + P+ +++++ ++s++ + l+++++ y + + ++ ++ NP_036459. 697 VVPlLsSPVLFQRLFSILLSLMSTYLLLSTG-------YEALFPLVLSCL 739 mppfGisiAvttlvGqnlGAgnyerarraarlglklslliglilalllll m+ ++ ++++ ++ ++++ l + + NP_036459. 740 MFV------------------WINIEQETLQQS---GVCCKQKLTSIQFS 768 fpepiasllftsdpe.vialaaqlllilais....qpfdlFvgiqvvlsG + i ++ + ++ +a+ + l++a++++++ +++ ++ +++ NP_036459. 769 YNTDITQFRQLYLDDiRRAFFLVFFLVTAFFgtgnIASIN--SFDLASVY 816 vlrGaGdtkvpliislisywgirlPlayllafftgfgknfwllltglgla ++ + p++++ + +w i +P++++ + f + l+ + l + NP_036459. 817 CFLT---VFSPFMMGALMMWKILIPFVLVMCAF----EAVQLTTQ-LSSK 858 GvWlgliignlvaaiigvvlallwrllrrwrkgteaaaekaa<-* ++l++ +++ i al++++l + g ++ + ++ NP_036459. 859 SLFLIVL---VISDIM----ALHFFFLVKDY-GSWLDIGTSI 892 COG2064: domain 1 of 1, from 349 to 892: score -297.4, E = 62 *->rRlylkdllkressykeLekaiekaflamlkerylklAlkys...lL l dl k es + + + +e m+ + + l + + +lL NP_036459. 349 --LNNTDLFKAESMFTNAVQILEQFKVKMTQKKEVTLPFLFTpfkLL 393 edikgavigLlaaevlv.svylPpvF....llsire.gviiYwlFllafv +d k i+ +a + + +v ++l+ + ++g+ Y + + f NP_036459. 394 SDSKQFNILRKARSYIKhRKFDEVVSlckeLIHLALkGLSYYHTYDRFFL 443 iayAiavliagiflvrliivlYPyvvi...eerkkkIdesLPhAvaFmya + + ++ i l+i+ + +i++ + kk LP + + + NP_036459. 444 GVNVVIGFVGWISYASLLIIKSHSNLIkgvSKEVKKPSHLLPCSFVAI-G 492 LSkgGmPLve.......IlriLAkNeevYGevSkEakkIVtdvevfGyDi + L++ + + + L +++ +v +E+++I +v NP_036459. 493 ILVAFFLLIQacpwtyyVYGLLPL--PIWYAVLREFQVIQDLV------- 533 ITAlkrvadtTPSdkLkeFleNliailesGgDlkeylkekyEyllEerel + t P + l + +e+ + ++ +++ + l NP_036459. 534 -----VSVLTYPLSHFVGYLLAFTLGIEV--LVLSFFY----RYMLTAGL 572 eqkeflEll.gilaefyvillvagPLfliivlvVvskmgsieltaleige + + + +l+++ + + l + l+ ++ + + ++++ +++ NP_036459. 573 TAFAAWPFLtRLWTRAKMTSLSWTFFSLLLAVFPLMPVVGRKPDISLVMG 622 flllprgsfekakliklltpieegvmarekarlgevpissrlasavervl +ll + ++ +v +++r ++ i+ +l + ++ vl NP_036459. 623 AGLLV-------------LLLSLCVVTSLMKR-KDSFIKEELLVHLLQVL 658 prgvsslkrlkkrleellylagievkaslyvilalllllgiisavlafiv ++ + ++ l+++++ +++ i+++ +++++s+v+ +++ NP_036459. 659 S----TVLSMYVVYSTQSSLLRKQGLPLMNQIISW--ATLASSLVVPLLS 702 g.llig..lsilkfllalliallgvflaflylpfypfieykrRveeiEre +++l+ + +sil++l + + l ++++ +l+ ++ + + + +iE+e NP_036459. 703 SpVLFQrlFSILLSLMSTY---LLLSTGYEALFPLVLSCLMFVWINIEQE 749 lPdFLrqlasllraGvslseAleevasksdyGpLtkEfrrivaemklwGr + l +Gv + l+++ s +t+ + + +++ NP_036459. 750 T---------LQQSGVCCKQKLTSIQ-FSYNTDITQFRQLYLDDIR---- 785 sledALerfeernlkSpvlsravriitealksGGdlsdvLeivakdleee ++f + ++++a +G+++ i + dl+++ NP_036459. 786 ------RAFFLV-----------FFLVTAFFGTGNIA---SINSFDLASV 815 erlkrelkaqtlmyvifiYvafavvipivliivgsilstlasvlagvatS + +++ ++ +++ + ip+vl++ + + l + NP_036459. 816 YC----FLTVFSPFMMGALMMWKILIPFVLVMCAFEAVQLTT-------- 853 kikgqdaqqLtavkvkayklvlfgtsliqaflsGlvaGvigeGsisaGlk +l +li++++s ++a NP_036459. 854 ------------------QLSSKSLFLIVLVISDIMA------------L 873 hiiIllivaYaiFkllpgf<-* h++ l+++++ + +++++ NP_036459. 874 HFFFLVKDYGSWLDIGTSI 892 COG2245: domain 1 of 1, from 744 to 894: score -104.7, E = 76 *->vikMeLsnAKllgGiGaiLqLvGaavgllGiLiwiLSivGlVLvLia i e + + G+ +L ++ NP_036459. 744 -INIE-QETLQQSGVCCKQKLTSIQFSYN------------------ 770 lymISkqvgddrIFnyyLigfismvaglilfvivifAtvGvsivallkks ++ ++ + a +++f+ v+ +G+ +a+ s NP_036459. 771 ----TDITQFRQLYLDDIRR-----AFFLVFFLVTAF-FGTGNIASI-NS 809 m..mslahglaalgsiLaGfViLyIayiigtyFqkKsyEliAqyTgVdmF ++ s +l+ +++ G ++ i + ++E++ T ++ NP_036459. 810 FdlASVYCFLTVFSPFMMGALMMW-KILIPFVLVMCAFEAVQLTTQLSSK 858 rtAGLlYfiGaiLLIVlGvGflilliAaILeiVaFFSLPdEikaseq.aa ++ LIVl i +I + FF d + ++ NP_036459. 859 ----------SLFLIVL-------VISDIMALHFFFLVKDYGSWLDIgTS 891 Vsp<-* +s NP_036459. 892 ISH 894 COG0475: domain 1 of 1, from 521 to 895: score -202.2, E = 13 *->atsfllelaiiLlvafllgiillakrlrlPpvlGyliaGiilGpsgl a + +++ L+v++l+ + l+ +Gyl+a ++l NP_036459. 521 AVLREFQVIQDLVVSVLTYP--------LSHFVGYLLA------FTL 553 gklliiessetiklLaelGvilLlFliGLEfdle..kLkkvgkrafglgl g ie+ +++++ ++++GL + L + + ra + NP_036459. 554 G----IEV-LVLSFF-----YRYMLTAGLTAFAAwpFLTRLWTRAK-MTS 592 lqgvltplllglllllyvlGlsfiaalflGgiLslsStaivvkiLedlgl l+ +++lll+++ l+ v G + +l++G++L + + + + l + NP_036459. 593 LSWTFFSLLLAVFPLMPVVGRKPDISLVMGAGLLV--LLLSLCVVTSLMK 640 lktreGqlalgalifeDiaaillLalvpalasggsgsdp..Gl.deanel k+ + + l + +++ ++++l + +v + s+ +++Gl++ n++ NP_036459. 641 RKDSFIKEELLVHLLQVLSTVLSMYVVYSTQSSLL---RkqGLpL-MNQI 686 gglvvlllkiaaffalllllgrylvprllrlvakdtgsrelfll.tvLll ++ +l ++++ ++ +l+ +l+ ll l++ l ++ +L+ NP_036459. 687 ISWATLASSLVVPLLSSPVLFQRLFSILLSLMST---YLLLSTGyEALFP 733 vlglAyglaellGlsmiLGAFlAGlllseteyrkkhl............. ++++++ +++++++ e++ + +++ ++ + + NP_036459. 734 LVLSCL-MFVWINIEQ--------------ETLQQSGvcckqkltsiqfs 768 .........eLaeklispfrgfFiPlFFi..svGmslDlgvlleailllL +++ ++ + L +i+ r fF+ +F ++ ++G ++ +++ l NP_036459. 769 yntditqfrQLYLDDIR--RAFFLVFFLVtaFFGTG-NIASINSFDLA-- 813 avilalllivvailgKilavyllarllgfskregdfrealkiGlllaprG + + ++ ++ al ++ l+p NP_036459. 814 --------------SVYCFLTVFSPFMMG---------ALMMWKILIPFV 840 EfsliiaslGlalglisevpetlfaalilvvlismiitPlllkllykrkl ++ ++ ++ l +l s +lf ++++ + i+++ + +l+k + ++ NP_036459. 841 LVMCAFEAVQLTTQLSS---KSLFLIVLVISDIMALHFFFLVKDYGSW-- 885 gaarvekaae<-* + + + ++ NP_036459. 886 LDIGTSISHY 895 COG1079: domain 1 of 1, from 519 to 895: score -198.6, E = 41 *->vdsslkgl.rksrlssllvpvlavilgllvgaivlailGynPle... ++++l++++++ +l+v+vl+ l+ +vg +++ +lG+ +l + NP_036459. 519 WYAVLREFqVIQ---DLVVSVLTYPLSHFVGYLLAFTLGIEVLVlsf 562 vymvlfsisyslinlllsltgVikatPLiLaALGgafseraGvfNIGlEG +y +++ +++ +++ +lt+ t ++ L+ f NP_036459. 563 FYRYMLTAGLTAFAAWPFLTR--LWTRAKMTSLSWTF------------- 597 QmifGAfaaalvalytggslsr.ptllalwlgllagalaGgllglih... f+ +l+ + + + +r+p + l + ag+l+ +l +++++ NP_036459. 598 ------FSLLLAVFPLMPVVGRkPD---ISLVMGAGLLVLLLSLCVVtsl 638 .....avLkvklkan..evIsGimlNlialgltnflvs.pylgkavtnpi ++++ ++k l ++ +v+s++ l++ +++ t ++ +l k++ + + NP_036459. 639 mkrkdSFIKEELLVHllQVLSTV-LSMYVVYST----QsSLLRKQGLPLM 683 stslyettvpvsarlpllfglfsf..................sgllpgvl ++ +t+ +s+ +pll + ++f++ + + ++ ++g+ ++++ NP_036459. 684 NQIISWATLASSLVVPLLSSPVLFqrlfsillslmstylllsTGYEALFP 733 laialaiivwylLyk..............TvfGlrlravGenPeAAdyaG l+++++ +vw+ ++ ++ ++++ +++ T++ + + n + +++ NP_036459. 734 LVLSCLMFVWINIEQetlqqsgvcckqklTSIQFSY-----NTDITQFRQ 778 i...nVkryrlfsmliSGalAGLa..GallvlgvqgklTfsvidftlgmt ++++r+ ++ +++ a+ G ++ +++ + +++ +++ l+++ NP_036459. 779 LyldDIRRAFFLVFFLVTAFFGTGniASINSFDLAS------VYCFLTVF 822 aGlGFiAIAialigrwnPlgvvfaSlLFgFsalliigssalqlntgtvle + +g +++ +++ F l+ +a+ql+t NP_036459. 823 SPF--------MMGALMMWKILIP---FV---LVMCAFEAVQLTTQL--- 855 vPseLvdlipyiiilvvlaalfglrrvrrglrvpralGrpydkg<-* +++L++++ i + +l + f+++ ++ ++ +G NP_036459. 856 SSKSLFLIVLVISDIMALHFFFLVKDYG----SWLDIGTSISHY 895 COG1271: domain 1 of 1, from 441 to 902: score -337.4, E = 60 *->mfmmdvvdLsRlQFAlTal.....................fHiL... f+ v++++ + + a+ +++++ ++ +++ +++ H L+ + NP_036459. 441 FFLGVNVVIGFVGWISYASlliikshsnlikgvskevkkpSHLLpcs 487 FVplTiGLsfmlai..mEtlylktkde...iYkdmtkFWgKlFainFAlG FV ++i ++f+l+i+ + y++++ + +i++ + + ++ + NP_036459. 488 FVAIGILVAFFLLIqaCPWTYYVYGLLplpIWYAVLREFQVIQDL----- 532 VvTGivmefqFGtNWsgfseyVGdvfGaPLaiEglfAFFlEstFLGiflF Vv+ v ++ s++VG ++ L+iE L++ +F NP_036459. 533 VVS--VLTY-------PLSHFVGYLLAFTLGIE----------VLVLSFF 563 GWdRvsNkklHllstwlVAiGtnlSAfWIlvaNSWMqtPaGfefvdetgr +++ ++ +l +++ w f + r NP_036459. 564 YRYMLT-AGLTAFAAWP------------------------FLTRL-WTR 587 geitmvsflaavfNPsapvkflHtvla.....aylTGaffvagisAyyll ++ m+s +f+ v l v +++++ +++ Ga ++ +++ + NP_036459. 588 AK--MTSLSWTFFSLLLAVFPLMPVVGrkpdiSLVMGAGLLVLLLSLCVV 635 kgktkerrekefakkslkvalvigliasilqiisGDlsgyglaeyQPvKL ++ + r+ +f k+ l++ +lq +s ls+y ++ +Q NP_036459. 636 TS-LMK-RKDSFIKE--------ELLVHLLQVLSTVLSMYVVYSTQ---- 671 AAmEglweTepapPmaalflfgipnfeneeeknkfaieIPyaLSlLAtrd + + +++ p m+ ++ ++++ + +P++ S + ++ NP_036459. 672 -SSLLRKQGLPL--MNQIISWATLA--S-------SLVVPLLSSPVLFQR 709 ldgpVpGlkdlppenekrirtGirAyllerLra................. l + + l+ l+ +++ + tG +A l+ L ++ + ++++ ++ NP_036459. 710 LFS--I-LLSLMSTYL-LLSTGYEA--LFPLVLsclmfvwinieqetlqq 753 ............lrqFnvKkDLGyGlllkRYtdvtdateaqiqaaadkad ++ +++ ++ + +n td+t + +++ d NP_036459. 754 sgvcckqkltsiQFSYN-----------------TDITQFRQLYLDD--- 783 epPlvahtffsfrIMvGlgglimllvalialwltlrgkkkvdrieqkkwl ++ ++++ff +G+g i + + + ++ + ++ + NP_036459. 784 IRRAFFLVFFLVTAFFGTG-NIASINSFDLASVYCF--LT---VFSPFMM 827 LwllllsiPlpfiAieaGWivaEvGRQPWvVygilkTtavaasaltagsi l+++ i++pf+ V+ + + ++l+++s NP_036459. 828 GALMMWKILIPFV----------------LVMCAFE-AVQLTTQLSSKS- 859 lfslilFvvlYtvLliaevy..llfrlirkgpvehelateeseseqw<-* lf ++l++ +++L +++++++ l +h ++ ++ NP_036459. 860 LFLIVLVISDIMALHFFFLVkdYGSWLDIGTSISH----YVIVMSMT 902 COG3069: domain 1 of 1, from 595 to 907: score -281.9, E = 73 *->lelfeliIgViViiavgYfIiKgYkprgVL.iaaGllLlIltlilGh ++f l+ +V + v g kp L ++aGll l+l+l NP_036459. 595 WTFFSLLLAVFPLMPVV-----GRKPDISLvMGAGLLVLLLSLCV-- 634 kvlpdstkStGylatD..ifeyvktmLsnRggGLGMmImsscGfAmyMeh + + D+ i e+ + L L + ++ + y++ NP_036459. 635 -------VTSLMKRKDsfIKEELLVHL------LQVLSTVLSMYVVYSTQ 671 iGanttvVkLlskPLslIkSPYiLlaaayiIacLmslaisSAtGlgvLlm + + L L l + +++ a++ L+ sS l NP_036459. 672 SSL------LRKQGLPLMN---QIISWATLASSLVVPLLSS-----PVLF 707 aTLfPvlvslGVsrlaAvAvlaspaaIilgptSgdvvlAAqvsgmklatf + Lf +l sl l + ++l+ + NP_036459. 708 QRLFSILLSLMSTYLLLSTGYEALFPLVLSCLM----------------- 740 afktqLPVsicaIIsmAiahFFwqryLDKKdninhEkvdqseldqvpPly F w in E+ + q ++ NP_036459. 741 --------------------FVW---------INIEQETL----QQSG-- 755 YAiLPflPiIgvLGSlFdgkvgpmqeLhivtimllsliigiiVefirkRf v q+L ++ + ++ +r NP_036459. 756 --------------------VCCKQKLTSIQ-----FSYNTDITQFRQ-- 778 NlretlkdlEaffdGMgdaFANVVmLlVAAgVFAqGLksIGavDalIslA l+d+ +f V lV A +G + ++ s+ NP_036459. 779 ---LYLDDIRRAFF--------LVFFLVTA------FFGTGNIASINSFD 811 eesGlggifvmliltiltvlaAivTGSGNAPFyAFveliPklAaelGvnp s + ltv +G + + liP NP_036459. 812 LAS---------VYCFLTVFSPFMMG----ALMMWKILIP---------- 838 vvLimPmlqAsnLGRTvSPis..GVVVvtAGlAkvSPfEVVK........ vL m + A L +S s +V v + + f VK+ ++ + NP_036459. 839 FVLVMCAFEAVQLTTQLSSKSlfLIVLVISDIMALHFFFLVKdygswldi 888 RTavPmllGlVvviiatlvLvp<-* T++ V+v+ t+ Lv NP_036459. 889 GTSIS---HYVIVMSMTIFLVF 907 COG0651: domain 1 of 1, from 526 to 908: score -274.4, E = 17 *->MsalvlllillPLvaafllpillllgllgpfagltliallalivllv ++++ Lv+++l +l +++ l ++ ++ ++vl++ NP_036459. 526 ------FQVIQDLVVSVLT---YPLSHFVGY-LLAFTLGIEVLVLSF 562 llgyvlltglgalvggtlGgwlapfgivlelDplsalfllilalvgllvs + y+l+ gl+a+++ w+++ ++ ++ + s + + ll + NP_036459. 563 FYRYMLTAGLTAFAA-----WPFLTRLWTRAKMTSLSWTFFS----LLLA 603 lYsigymrrekgrgedsaavyyallllllagmlGafltgDlfnlyVFfEi ++ + + +k + l +++ l+++l + + NP_036459. 604 VFPLMPVVGRK-----------PDISLVMGAGLLVLL----------LSL 632 malaSyaLvalggtkealeaglkYlvlggvgsalfLlGigllYaatGTLn ++S ++ +++ +++ l+++++ ++ l+ ++Y++ +L NP_036459. 633 CVVTS----LMKRKDSFIKE---ELLVHLLQVLSTVLSMYVVYSTQSSLL 675 fadlaavllsglalaaflLlliGfgvKaglFPLHfWLPdAyseApspiSA ++ + + ++ ++ + ++PL P ++ s + NP_036459. 676 RKQGLPLMNQ--------IISWATLASSLVVPLLS-SPVLFQRLFSILLS 716 llSgvvvKvGvYaliRvllllfgglgideqelipaslgalllilaaltai l+S+++ ++ +++l+++ l ++++i + NP_036459. 717 LMSTYLLLST--GYEALFPLVLSCL-------------MFVWINIEQETL 751 fGvlmAllqsDiKRLLAYSsvsQmGy...IllglgiGtpgidlgpltala +q+ + Q y+++I + +i + NP_036459. 752 QQSGVCCKQK--------LTSIQFSYntdITQFRQLYLDDIRRA------ 787 laaalfHllnHalfKglLFLgAGaviyrtGtrdldklgGLakrmPlltal +FL+++ l+ta+ NP_036459. 788 -----------------FFLVFF----------------------LVTAF 798 afliaalslaGiPplnGFvSKwliiqallaaggsapvglpllavlllvgs + + s+ + + ++ +l++ + + ++l++ + NP_036459. 799 FGTGNIASINSFDLASVYC--FLTVFS-----------PFMMGALMMWKI 835 aitfayfvrllykffgggflgaPrsetepgakeapllmllpmlilallcl +i f++++ ++ ++ + +t+ k++ li ++++ NP_036459. 836 LIPFVLVMCAFEAVQL---------TTQLSSKSL-------FLIVLVISD 869 llGvapepvlkalgapaaallliytvkvsavlaglpdiai<-* +++++ ++k +g+++ +++ i+++ ++ ++ + ++ NP_036459. 870 IMALHFFFLVKDYGSWLDIGTSISHYVIVMSMTIF-LVFL 908 COG1585: domain 1 of 1, from 778 to 911: score -54.3, E = 50 *->lglllillgmlffvlwLilgtllllaemlipsffllwlglfalgvgl + l + f+v++L++++++ + ++ i sf l+ ++ f ++++ NP_036459. 778 QLYLDDIRRAFFLVFFLVTAFFGTGNIASINSFDLASVYCFLTVFSP 824 lvgylpvlswlqllvfallsilaaflawrrllrrvksqkssksglgkrga +++ +w +l+ +++++ a + +++ + ssks + NP_036459. 825 F-MMGALMMWK-----ILIPFVLVMCA-FEAVQLTTQL-SSKSLFLI--- 863 eeLiGkvgtvvepiepggeGrVkveGerWrArsedddedlekGekV..kV v+ +i +++ +v + ++ ++l G+ ++++V NP_036459. 864 -------VLVISDIMAL-HFFFLVKD-----YG----SWLDIGTSIshYV 896 VaveGltLvVkkaee<-* + ++ + +V + NP_036459. 897 IVMSMTIFLVFLNGL 911 COG1055: domain 1 of 1, from 546 to 912: score -226.7, E = 98 *->sllalfslllftlvylliipeglnravaallGAllllalghivvtle + l++f l++ +lv+ + + l ++ +a+ A++ +++ + t + NP_036459. 546 GYLLAFTLGIEVLVLSFFYRYMLTAGLTAF--AAWPFLTR--LWTRA 588 dafnerksevagidwntiflLlgmmIivlil..............aesGF + +++w+ + lLl++ + + +++++ + + + +++ NP_036459. 589 KMT--------SLSWTFFSLLLAVFPLMPVVgrkpdislvmgaglLVLLL 630 FeyvAfilislakrskgsgiLvagdlNrtfklLllllvlltAliSAfldN + v +sl+kr++ + + +l L ll +l++++S+ NP_036459. 631 SLCVV---TSLMKRKDSFIK---EEL------LVHLLQVLSTVLSMY--- 665 dttiLlltPivlavadrlglnprivvpfllaivfiANiggtat..lvGdp +v ++ l ++ +p i+ A ++ + +l + p NP_036459. 666 ---------VVYSTQSSLLRKQG--LPLMNQIISWATLASSLVvpLLSSP 704 pNiiiasaaglsFldFalnmappvlvalaavlvvlyllyrrilskryeve + ++ ++++ l++l++++++l y ++ + + NP_036459. 705 V---------------LFQRLFSILLSLMSTYLLLSTGYEALFPLVLSCL 739 drvalkdpkeaikdrrgllilslvvlalvliafflgesflgiplslvAla +++++ +++l s+v ++ +++i+ s + + NP_036459. 740 M------FVWINIE-QETLQQSGVC--------CKQK-LTSIQFSYNTDI 773 gAaillliarvaaakvgkknvekvlrkveWgtLlFfiGlfvvVggLekaG + l++ + + ++ v+ v t +F +G ++++ +a NP_036459. 774 TQFRQLYLDD------IRRAFFLVFFLV---TAFFGTGNIASINSFDLA- 813 vtellaekllslltsgnlaaatlgigwlsgllSsvvdNiPlvlimiptvk + + l ++ ++l++ + iP+vl+m NP_036459. 814 -----SV-YCFLTVFSPFMMGALMMWKIL---------IPFVLVMCAF-- 846 elaalmgggveldlfplwwAlalGAdlGGnlTpIGslAnlvwlgilerkG e+++l ++ ++ l++++++ +d++ + l + NP_036459. 847 EAVQLTTQLSSKS---LFLIVLVISDIMA-----------LHFFFLVKD- 881 vpiSFleYlKvGlivtlpsllvtllyLyirysvll<-* ++ l +G + + +++ +++++++++l NP_036459. 882 ----YGSWLDIGTSISHYVIVMSMTIFLVFLNGLA 912 COG2244: domain 1 of 1, from 471 to 915: score -192.2, E = 14 *->slkrrllkgsivlsiatliskllgfvvlvllaRllGpegfGlyafal + ++ +k+ + l+ +++ ++ +++ + +a NP_036459. 471 KGVSKEVKKPSHLLPCSFVAIGILVAFFL-------------LIQAC 504 aflgllviladlGlplalsryvaeyrekgdkerarrllstvlvltillsv + + + l l + +a+ r++ + l+++vl++++ v NP_036459. 505 PWTYYVYGLLPLPIWYAVLREFQV---------IQDLVVSVLTYPLSHFV 545 llflilllaapfiaefflnlkdpdlaalirllalalllisiisflrgifq +l++ l+ ++ +++++ + + +++l +++ + + NP_036459. 546 GYLLAFTLGIEVLV------LSFFYRY-MLTAGLTAFAAWPF-----LTR 583 gfqrmkylalsqviesilrfllilslvflillvlsvlllgasGaAalaav + r+k ++ls+ + s+l ++ l+ ++ ++ ++ v NP_036459. 584 LWTRAKMTSLSWTFFSLLLAVFP----------LMPVVGRKP---DISLV 620 igalvvgavlslligliklgrkflkpsrkalfkrllrfgiplllsslagl +ga ++ ++lsl++ ++rk + ++ +ll + + +l + l+ + NP_036459. 621 MGAGLLVLLLSLCVVTSLMKRKDSFIKE-----ELLVHLLQVLSTVLSMY 665 lygyiDrillgafLgAGvastlgdeavGiYngaaqplvtvllilasslst +++++ + ll + pl++ +++ a+ s+ NP_036459. 666 VVYSTQSSLLRKQ--------------------GLPLMNQIISWATLASS 695 vlfPyisrayeegklkllslflksllrlllilaiPaalglllladplill ++P +s + +l + l l+s+++ll+++ a++ l+l +++++ NP_036459. 696 LVVPLLSSPVLFQRLFSILLSLMSTYLLLSTG-YEALFPLVLSCLMFVWI 744 lfgekylgseaapllillilvfllsilgvpgaslLqalgktklalyislf + l+ +++ + + ++ +s+++ + ++ q ++ +++f NP_036459. 745 NIEQETLQ-QSGVCCKQKLTSIQFSYNTDIT-QFRQLYLDDIRRAFFLVF 792 gallnlvLnf.llLiprfGieGAAla...........tvisyaivtilsi ++ ++++ i+ f ++ + ++ + ++ +++ ++++ NP_036459. 793 FLVTAFFGTGnIASINSFDLASVYCFltvfspfmmgaLMMWKILIPFVLV 842 iysrklgglsaklkkilklliaallmalgivvlavllllllillaaaglv + + +l+ l+ +k l+++ l++ i++l +l++ ++ ++ + + NP_036459. 843 MCAFEAVQLTTQLS--SKSLFLIVLVISDIMALHFFFLVKDYGSWLDIGT 890 galillgalvavglavrdylllrls<-* ++ ++ + ++v+++ l l NP_036459. 891 SISHYVIVMSMTIFLVFLNGLAQLL 915 COG2851: domain 1 of 1, from 618 to 915: score -378.6, E = 30 *->meiMLt.lLGFlmvlvfvwLiltkrlSPliALIiVPIvfALIaLiLE ++M ++lL +l l v +++ + S +I + + L+ NP_036459. 618 SLVMGAgLLVLLLSLCVVTSLMKRKDS----FIKEELLVHLLQ---- 656 RLGFGvGvALGvKGGvFDikelgemmleGiksVaptaiMlmFAILYFGIM v ++++ m+ V +t + + NP_036459. 657 -----V------------LSTVLSMYV-----VYSTQS---------SLL 675 iDsGLFDPligkiLsivKGdpvkvavGTavlAmlvsLDGdGaTTYlItvp GL Pl + i+s +T + +++v L + p NP_036459. 676 RKQGL--PLMNQIISW----------ATLASSLVVPL---------LSSP 704 AlLPLYkRL.GmnplvLallamlsaGVmNmiPWGGPTaRAAsvLgvDpae L +RL + ++ + + ls G + P ++s L NP_036459. 705 V---LFQRLfSILLSLMSTYLLLSTGYEALFP------LVLSCLMF---- 741 lfvPL..IPvmiiGlllilaLAylLGkrErkRGlGvlnlsapGwnsitkd +++ +++ +++ +G+ + + l ++ s NP_036459. 742 VWINIeqETLQQSGVCC------------KQK-LTSIQFSYN-------- 770 eadaaepaeieaeelkkkkDrsLARPKLlWlNLLLtial.....mglLvs +d + ++ ++++ + ++l ++L+ a ++++++ + s NP_036459. 771 -TDITQFRQLYLDDIR----------RAFFLVFFLVTAFfgtgnIASINS 809 GilPlpvlFMIAfaiALllNYPnvkeQkkRIaaHAgNaLlvvslIfAAGi l + ++F++ f ++ +aL++ +++ NP_036459. 810 FDLASVYCFLTVFSPFMM------------------GALMMWKILI---- 837 FtGILsGTGMvDAmaksivsliPdalGPyLplIvAilsvPFtfvlsnDAY P+ ++ A +v +t ls + NP_036459. 838 ---------------------------PFVLVMCAFEAVQLTTQLSSKSL 860 YFGvLPIveeaasaYGidpveiArAsiiGqpVghllSPLVPsTyLlvGLA + vL I a ++ + + iG + NP_036459. 861 FLIVLVISDIMALHFFFLVKDYGSWLDIGTSI------------------ 892 kvdfGdHqRFslkWAvgiSlViliiAllaGIipll<-* +H ++ +S+ i++ l G+ ll NP_036459. 893 -----SH------YVIVMSMTIFLV-FLNGLAQLL 915 COG3307: domain 1 of 1, from 532 to 916: score -148.5, E = 32 *->mmaalllsrkrhkgvakrlllwvslpillllilpgafalglavvlla + l+ +h+ +ll + l i++l++ ++ l ++l a NP_036459. 532 LVVSVLTYPLSHF---VGYLLAFTLGIEVLVLSFFYRY-MLTAGLTA 574 llallflatavvvllfltLrgalysldikalslllllflaywlslallll + a +fl+ l+ + ls++++++l++ ++l++ + NP_036459. 575 FAAWPFLTR-----LWTRAKMT-------SLSWTFFSLLLAVFPLMPVV- 611 siivdssalrstlflllntirlllflwlclllkaklrlperlkstllyal ++d+s + + + + ++lll+l + ++l + + ++ + +l l NP_036459. 612 GRKPDISLVMG----A-GLLVLLLSLCVVTSLMKRKDSFIKEE-LLVHLL 655 llgsfilRqallaliQfflledPlffstsltprasgygvfsgnplvlaav + s l + ++++ ++ + + ++ n+ ++ a+ NP_036459. 656 QVLSTVL--SMYVVY--STQS---------SLLRKQGLPLM-NQIISWAT 691 lstgflgqyLlvlllfallanqkrkiRWskllgllsvilallvlvLtgSR l+ +++++ + ++ +++ l s++l l+ + L S NP_036459. 692 LA-----------SSLVVPLLSSP----VLFQRLFSILLSLMSTYLLLST 726 gWLallallaillalliaylraskkkrllglallvlllllalitfskaLy g+ al l++++l +++ + + +l + + l +i+fs NP_036459. 727 GYEALFPLVLSCLMFVWINIE----QETLQQSGVCCKQKLTSIQFS---- 768 krtvIiqervvearfelvsiregnseadsslgaRlevWeaAlaaiqerPi ++ +++ ++ +++ R++ + l ++ + NP_036459. 769 ---------YNTDITQFRQLYLDDI--------RRAFF---LVFFLVTAF 798 fGhGagefdeaynllnaeqkryeaklaLlllgHaHN.iyLeilaetG.li fG+G ++n+ + l++ + + + + +G l+ NP_036459. 799 FGTG------NIASINS-----------FDLASVYCfLTVFSPFMMGaLM 831 GtvlllwlailllafgillkkratrglelaRRslilalgllialismlfy +l+ ++++ +af ++ + ++ sl l+ ++++ + ++ f+ NP_036459. 832 MWKILIPFVLVMCAFEAVQLTTQLS-SK----SLFLIVLVISDIMALHFF 876 ltvdsa.vwFlipisgllflflaiiarglasaktalkaal<-* + v +++ w++i s + ++ + + ++l + ++ + NP_036459. 877 FLVKDYgSWLDIGTSISHYVIVMSMTIFLVFLNGLAQLLT 916 COG1178: domain 1 of 1, from 443 to 918: score -331.0, E = 54 *->vvasly.v.m.ysaillvlavgalatlatvklvvmggdplriglwll + + + ++ + + +l ++ +l + +++ ++ + +++ + NP_036459. 443 LGVNVViGfVgWISYASLLIIKSHSNLIKGVSKEVKKPSHLLPCSFV 489 iglllaalllllpplvlavlalsafsgglaeflavlsdayllrllgnTLl ++ +l+a ++ll+ a ++ ++ +g + ++ l + ++ NP_036459. 490 AIGILVA-FFLLI---QACPWTYYVYG------LLPLPIWYAVLREFQVI 529 lallvTvlslilGlplAyllsrydfPGrrwlrwllaLPiLLviPalvvAf + l v vl+ l ++ yll+ ++L + NP_036459. 530 QDLVVSVLTYPLSHFVGYLLA-------------FTLG----------IE 556 gfislfGksGwLarllgelfGlssreywlpdiygPlgGiilalvlfnyPl ++++ f ++ y + + +++ +P+ NP_036459. 557 VLVLSF-----------------------FYRYM---LTAGLTAFAAWPF 580 vyllaaaalesidpsleEaArsLGasrwqvFrrVtLPllrPaiaagalLv + +l a ++++ s w +F lL NP_036459. 581 LTRLWTRA--------KMTSLS-----WTFF---------------SLLL 602 FlyclsdF.....gavliLGGspqytTlttaIyqeilgsqldlatAalLa +++ l+ + +++++++l++G + + l++ + +++ +++ lL NP_036459. 603 AVFPLMPVvgrkpDISLVMGAGLLVLLLSLCVVTSLMKRKDSFIKEELLV 652 llLLllsllllwvvvkllerfsrg.rqkvyssgqswarpiprilllglaa lL +ls++l +v ++ + s +++q + +q +++ + +l+ + NP_036459. 653 HLLQVLSTVLSM-YVVYSTQSSLLrKQGLPLMNQIISW-ATLASSLVVPL 700 lvallfclllfsvlllgvilplsflllWtvlltsdewsdamlgplfstsf l +++ lfs+ll +l ++ + l+ + ++ ++ + NP_036459. 701 LSSPVLFQRLFSILLSLMSTYLLLSTGYEALFPLVLSC--------LMFV 742 whalin.sLtlallAa...lialllaLllaylvrrsrsrlsrfidrLsmL w ++ +++L ++++ +++l ++ + + + r+ i r+ +L NP_036459. 743 WINIEQeTLQQSGVCCkqkLTSIQFSYNTDITQFRQ--LYLDDIRRAFFL 790 plAvPGvVlalGllllfnnldnhwvdlaameGvkpllvlygtllllVlAy + + ++G + n +d l+ V+++ NP_036459. 791 VFFLVTAFFGTGNIASINSFD----------------------LASVYCF 818 alralPfalrsleaalrqidprLeeaArsLGasrwqifrrvtLPLllpgl +++++Pf++++l +++++ l p++ NP_036459. 819 LTVFSPFMMGAL------------------------MMWKI----LIPFV 840 laAaalvFalsmkEls....ATllLgppdftTLttaiynylsggdgryaa l a+ + ++ls+++ + ++L+ d +++ + ++ d+ NP_036459. 841 LVMCAFEAVQLTTQLSskslFLIVLVISDI--MALHFFFLVK--DYGSWL 886 AavllvasaAlvLvlislllfvllikrygersqgt<-* + + s++ + +s+ f+++++++++ ++ NP_036459. 887 DIGT---SISHYVIVMSMTIFLVFLNGLAQLLTTK 918 COG2252: domain 1 of 1, from 635 to 918: score -389.0, E = 71 *->mgllerfFkLkehgTtvrtEiiAGLTTFLTMaYIvfVNPaILsaagv ++ l+ k ++ ++ E++ + + V +Ls v NP_036459. 635 VTSLM-----KRKDSFIKEELL---------VHLLQVLSTVLSMYVV 667 kde.eag......mpfgAvfvATcLaaaiGsllMG...LyANyPiALAPG ++ + ++++ + + + + La+ + + l++++ L+ ++ +L NP_036459. 668 YSTqSSLlrkqglPLMNQIISWATLASSLVVPLLSspvLFQRLFSILLSL 717 MGLNAFFAFtVVlgmGipWQvALgAVFisGvIFilLSltgvRewiinsIP M+ ++ + + AL +s ++F+ + + + NP_036459. 718 MS-----TYLLLSTGY----EALFPLVLSCLMFVWINIEQE--------- 749 rsLKlaigaGIGLFiAfIGLknaGIvVanpaT.........iLag.lVtL L++ G+ + + T+ + + +++i +++ + L NP_036459. 750 ------------------TLQQSGVCCKQKLTsiqfsyntdITQFrQLYL 781 GdltspgvlLallGlfliviLevrrVkGailigIlattiigwilglvvfe d+ + l++ ++++++++ ++ ++++f+ NP_036459. 782 DDIRRAFFLVF---FLVTAFFGTGNIA-----------------SINSFD 811 gaplgifsmPpdilqesiaptFlqlDiknaiitfsGalnlgllgVVftFf ++ ++ t++ ++Gal + + + f+++ NP_036459. 812 --LASVYCFL----------TVFSPF-------MMGALMMWKILIPFVLV 842 fVdlFDtlGTLiGVAqkAGlldkdGki.Pra.gKaLlADsistvfGAllG ++++ + +++++ +++K L NP_036459. 843 MCAF------------------EAVQLtTQLsSKSLF------------- 861 TSTvTaYIESaaGvaaGGRTGLTAvVVGvLFLLaylFfsPLakaiPavay L+ +V ++L Ff L+k + NP_036459. 862 ---------------------LIVLVISDIMALH-FFF--LVKDYG---- 883 ATAPALiyVGaLMmsnvkkIDfdDitEaiPAFlTiimMPLTySIAtGIAl + Di +i+ NP_036459. 884 --------------------SWLDIGTSIS-------------------- 893 GFIsYpivgaapKlftGrwkevspgvyiLAllFvlkfiflla<-* Y+iv s ++ ++l +++++ ++ NP_036459. 894 ---HYVIV-------------MSMTIFLVFLNGLAQLLT-TK 918 COG1593: domain 1 of 1, from 390 to 920: score -382.7, E = 40 *->seavlsqkakevleelekeararrllsgkvllvvsvv...alglslf +++ k + +l+++ + +r++ ++v l +++ gls++ NP_036459. 390 FKLLSDSKQFNILRKARSYIKHRKF-DEVVSLCKELIhlaLKGLSYY 435 hlyt.tfagvlstlilrsv.hvAvflalafllypalrksklkgvplyDwL h y ++f gv + +++ v+ ++++ +l+++ + l k k v+ + L NP_036459. 436 HTYDrFFLGVNV--VIGFVgWISYASLLIIKSHSNLIKGVSKEVKKPSHL 483 LallalfsafYivlnyleLvlr.sggyttlDlvvmvvavllvleatrral L + f+a++i +++ L+++ + +y +v ++ l + a++r NP_036459. 484 LP--CSFVAIGILVAFFLLIQAcPWTY-----YVYGLLPLPIWYAVLREF 526 GvP..laislglfilygllgadppgvqahhgysfrvgadrlvtllilaqe v ++l++s++ l + g+ ++ + NP_036459. 527 QVIqdLVVSVLTYPLSHFVGYLLAFTL----------------------- 553 gvfGtpdsvsllaIplFiLfGaflnkgGvgkrlidlAkalvGhrrGGlAk G ++ +l++ + ++L++ l+ + + +l++l + Ak NP_036459. 554 ---G-IEVLVLSFFYRYMLTAG-LTAFAAWPFLTRLWTR---------AK 589 aaVvaSmLfgsiSGSsvAnvvatGsftIPlMkraGYppefAaAveaaASt + ++ ++f + ++PlM +G +p+ + + +A++ NP_036459. 590 MTSLSWTFFSLL------------LAVFPLMPVVGRKPDIS--LVMGAGL 625 gGqLiPPsmgaiaF.....imaenvsIgYvdlfiAgiiPALLyflalmvm + +L ++ +++++ + e + ++ LL +l+ + NP_036459. 626 LVLLLSLCVVTSLMkrkdsFIKEELLVH------------LLQVLSTVLS 663 vyleAkknglpgrglkasqlpllkgt.................lalkeal +y + + l++ +lpl+ + + + ++ + ++++l ++l NP_036459. 664 MYVVYSTQSSL---LRKQGLPLMNQIiswatlasslvvpllssPVLFQRL 710 wlLllpvilIgglfsGgftPteAAavaaVAivlyalivalvsrrl..... + +ll + ++l s g+ +++ l+++ + ++++l++++ NP_036459. 711 FSILLSLMSTYLLLSTGYEALFPLVLSC----LMFVWINIEQETLqqsgv 756 ......i.llfiyrhtltglgklavalvlvkalgfivvilLlkGlrellk +++ ++ f y+ ++t ++ l l NP_036459. 757 cckqklTsIQFSYNTDITQFRQLY------------------------LD 782 dlleaLeegarttapVaiavAaAgiisgvititgipltladlllslsggn d+ +a+ V+++v a +++ +i +l + +l++ + + NP_036459. 783 DIRRAFFL-------VFFLVTAFFGTGNIASINSFDLASVYCFLTVFSPF 825 illllLllimlllLiLGmgmpttaayiIls.....pilaPvavqlllGid ++ L++ +l+ ++ +m +a+ ++++ +++++++ v+v d NP_036459. 826 -MMGALMMWKILIPFV-LVMCAFEAVQLTTqlsskSLFLIVLVI----SD 869 Pihaalahlfvfy..ngiigdiTPPVGlalFvaagvAgaDPmktgieafk ++ h+f++++++g+ di + +++ NP_036459. 870 IMAL---HFFFLVkdYGSWLDI----------GTSIS------------- 893 kaiapfivpflfvlspvllfpeisllglvwlpllligtai<-* +++v+s ++++ ++ l ll+ + NP_036459. 894 --------HYVIVMSMTIFLVFLNG-----LAQLLTTKKL 920 COG0697: domain 1 of 1, from 590 to 920: score -91.0, E = 15 *->llgllllllaaliWGssfvliKlaledgnyrifvvppltivflRfli + l + +++ l+ f+l+ ++ + + ++ ++ ++l +l+ NP_036459. 590 MTSLSWTFFSLLLAV--FPLMPVVGRKPD-----ISLVMGAGLLVLL 629 aallLlpllllrrr.lprr.pgkllllglgsnvetlllllglllglflyf +l+++ l r++++ + +++++ll +l+++l++++ + NP_036459. 630 LSLCVVTSLMKRKDsFIKEeLLVHLLQ-----------VLSTVLSMYVVY 668 llffyal..qytsasvaalltsl..aPlftallaflllgerltrlqllgl + + l++q++++++ ++ ++ + l+++ll++ +l +r l+++ NP_036459. 669 STQSSLLrkQGLPLMNQIISWATlaSSLVVPLLSSPVLFQR-----LFSI 713 llaflGvvllll..lggllllGillaLlaalswAlytvlgkrlsarvprp ll++ ++lll+++ l++l +l+ l+++ ++ + l +++ NP_036459. 714 LLSLMSTYLLLStgYEALFPL-----VLSCLMFVWINIEQETLQQSGVCC 758 .....................t.plpltivflqlllgallllplalflgg +++ ++ + + +++ ++ ++ + fl+++l ++++ + NP_036459. 759 kqkltsiqfsyntditqfrqlYlDDIRRAFFLVFFLVTAFFGTGNIASIN 808 pplssptl.pspfielsfwlallylgvlatalgyllwnyalrrlgaskaa ++ + ++ ++ +++ + +al +l ++ ++ + a+++ NP_036459. 809 SFDLASVYcFLTVFSPFMMGALMMWKILIPFVLVMCAFEAVQLTTQLSSK 858 llsylePvfalllg..wllLgErpltlaqll.....GaalilaGillvsl +l++++ v++ +++ ++++L ++ ++++ ++ ++++ i+lv+l NP_036459. 859 SLFLIVLVISDIMAlhFFFLVKDYGSWLDIGtsishYVIVMSMTIFLVFL 908 rarkrarkaase<-* + + + ++ NP_036459. 909 NGLAQLLTTKKL 920 COG1108: domain 1 of 1, from 671 to 922: score -172.3, E = 19 *->mmslLlellqyeflqnAllagllvslacgllGsflVlRRmaligDAl slL ++ + q + +a+l+ sl+ +ll+s +++ R+ + NP_036459. 671 QSSLLRKQGLPLMNQIISWATLASSLVVPLLSSPVLFQRLFS----- 712 SHaaLpGvalgyLltgqlglfllginpllgaiafgllgAlligflrrksk + l+ L++ ++l+ + + a + +l +l+ +++ + NP_036459. 713 -------ILLS-LMS-----TYLLLSTGYEALFPLVLSCLMFVWINIEQE 749 vkeDtaiGivfssglalGvvllsllpgfnn.savdlmnyLFGniLaVspt + + + Gv + +l + +++ ++d++++ ++ + + NP_036459. 750 TLQQS------------GVCCKQKLTSIQFsYNTDITQFRQLYLDDIRRA 787 DLwliaivslGP...............sVlclvllllllfyrelllisFD ++ + v++ ++++ + ++ + sV c +l + +++ NP_036459. 788 FFLVFFLVTA-FfgtgniasinsfdlaSVYC-----FLTVFSPFMMG--- 828 pefAkvlGipvrllhyllllLialtiVaavkaVGviLvsaLLiiPaatAr + + + +l+ ++++++ av+ +t + NP_036459. 829 -ALMM--------WKILIPFVLVMCAFEAVQ---------------LTTQ 854 llsrs.lrsmliiAillgllsgvl..........GvlllSyyldlppGps l s+s ++ +l+i+ +++l + +l ++ ++ + G ++S+y + s NP_036459. 855 LSSKSlFLIVLVISDIMALHFFFLvkdygswldiG-TSISHYV---IVMS 900 ivliatllfllslllrkkygvl<-* +++++++l +l++ll+ k l NP_036459. 901 MTIFLVFLNGLAQLLTTKKLRL 922 COG0670: domain 1 of 1, from 679 to 922: score -131.9, E = 76 *->MglydrmqsrnfektqaeargetliaqvvlkmtygLLltalvasaag +++ ++ + + +++++ +l+++ vl + ++ +l++l +++ NP_036459. 679 GLPLMNQIISWATLASSLVV--PLLSSPVLFQRLFSILLSLMSTYLL 723 afvalaallpspglfsttflvlilallglvfliflmikkrnsaY...... + ++ al+p + ++++++ +++ ++++ NP_036459. 724 LSTGYEALFP-----------------LVLSCLMFVWINIEQETlqqsgv 756 ...............................WYtglalffvytgLsGytL +++ ++ + + +++ ++ ++ ++ ++ ++++ +l++++ + +G + NP_036459. 757 cckqkltsiqfsyntditqfrqlylddirraFFLVFFLVTAF-FGTGNIA 805 spilnvylatsGaGgdvIasAFgiTaivFggmSayGlttrFNkkDlsflg s+ + ++++ ++++++ G+ + ++ NP_036459. 806 SINSFDLASVY-------------CFLTVFSPFMMGALM---------MW 833 kfLfmaLigLvvasLvNlvlGFslFlgssalnlaISalGvilFsglIlyD k+L+ ++++ v+ l ++ s +l + ++++ + l+ NP_036459. 834 KILIPFVLVMCAFEAVQ------LTTQLSSKSLF--LIVLVISDIMALHF 875 tqnIirggrkligddteisedlsIraALsLYLdfINLFlsLLrIlgilnd ++ +++ g + d +++ + I+++++++L f+N L ++l + NP_036459. 876 FFLVKDYG--SWLDIGTSISHYVIVMSMTIFLVFLN---GLAQLLTTKKL 920 dD<-* + NP_036459. 921 RL 922 COG3368: domain 1 of 1, from 518 to 923: score -210.4, E = 15 *->MkvevvrvtYrELhyrml.kenaaiSRnervlkdslkvqkniklavg ++ v+ + + +++ ++ S + +l +++ i + v+ NP_036459. 518 -IWYAVLREFQVIQDLVVsVLTYPLS---HFVGYLLAFTLGIEVLVL 560 llsfaFlvfgLFlvgpsf..yeakvslrsslfaLll.vfsliysiyntsL + ++ + l + + ++ ++ +r +L+ ++fsl + L NP_036459. 561 SFFYRYMLTA-GLTAFAAwpFLTRLWTRAKMTSLSWtFFSLLLAVFP--L 607 mvaylqsgkvlePLryLPvpriskvmsVlfFidtlpsglflaLPaiFLav m + + p+is vm + +++ l+ l +++ NP_036459. 608 MPV------------VGRKPDISLVMGAGLLVLLLS--LCVVTS------ 637 LllggiyegLlgllWlilAVLlGAySivlllqvkFGsvkvGkgslsknll L+ + ll +l V +S vl+++v v++ + ll NP_036459. 638 LMKRKDSFIKEELLVHLLQV----LSTVLSMYV----VYSTQS----SLL 675 RaFGlivllvivfliqlIvqlvkrnVemlipifqeYdvlfPisastsiyf R Gl ++ i+ + l lv l + + lf i+ s+ NP_036459. 676 RKQGLPLMNQIISWATLASSLVVP----LLSSPVLFQRLFSILLSL---- 717 PFsGiYmqAksfiLlLvYaalfallflYgiRklwesleepkvvGqseVKg +s ++++L+ Y alf l+ l+ +w +e ++ qs V NP_036459. 718 -MS------TYLLLSTGYEALFPLV-LSCLMFVWINIEQETLQ-QSGVCC 758 eykiksrskltsmliKDfKiif....RktQLlvllllPlyivlpqivsva k+ s i f+++ ++ R+ lv +l+ +++ +i s+ NP_036459. 759 KQKLTSIQFSYNTDITQFRQLYlddiRRAFFLVFFLVTAFFGTGNIASIN 808 kygPlpkrasillltaigalasiTssldvslfmeLEgnGvsflkaLPLsk + +++ lt ++ + g NP_036459. 809 S---FDLASVYCFLTVFSPFM--M------------G------------- 828 refllsKillmslIpafvSltilAaafiynGgglanslyifplvlapllv + ++Kil ++++ +++a +++ + l+ l+l++l+ NP_036459. 829 -ALMMWKILIPFVL-------VMCAFEAVQL---TTQLSSKSLFLIVLVI 867 SvissmklvseKinveavevpnlsFfdgIvFillvnfiavvvgkapiFsl S i + + ++ l + I v+v + iF + NP_036459. 868 SDIMALHFFFLVK----DYGSWLDIGTSIS-------HYVIVMSMTIFLV 906 sqPDLLRLnAYFvslIitdvviivlslllfrkakll<-* ++ ++ ll +k++l NP_036459. 907 FLN-------------------GLAQLLTTKKLRLC 923 COG0573: domain 1 of 1, from 658 to 925: score -219.6, E = 41 *->tstasiedtkskrqlksrlkkkiseklfkillllaAvivilalvlia +st+ + + q + ++k + l ++++ a + ++l + NP_036459. 658 LSTVLSMYVVYSTQSSLLRKQ--GLPLMNQIISWATLASSL-----V 697 vfLliesipafqkfGvklnFftsteWnPtdeekyGvLplIvGTPlitsli v Ll + + + f++ l + st+ ++ + y +L+++v + l+ i NP_036459. 698 VPLLSSPVLFQRLFSI-LLSLMSTYLLLSTG--YEALFPLVLSCLMFVWI 744 Al...............lIAlPlGigtAi..FlsEryAPkrlrrvlkpai +++++ ++++ +++l ++ ++ t i++F y + r ++ + NP_036459. 745 NIeqetlqqsgvcckqkLTSIQFSYNTDItqFRQL-YLDDIRRAFFLV-- 791 ElLAGIPSVvYGlFGlfvlaPlladyiapfLneylfdipvllFsgpPgtg +f ++ ++ ++i + NP_036459. 792 ---------------FFLVTAFFGT----------GNIA---------SI 807 rnlLsAgivLgiMIiPtiaSisrDalrsVPkslkEaalALGATkwetirk ++ A++ ++ V + +al + +k NP_036459. 808 NSFDLASVY---------------CFLTVFSPFMMGALMM--------WK 834 VilPaArpGIvggviLGlGRAlGETMAVtmviGntprlpsinpaslfdpa +++P ++ v+ ++ +++ t +l+s +slf + NP_036459. 835 ILIPFVL------VMCAFE-----------AVQLTTQLSS---KSLFLIV 864 rTltaaIAnefggeaaggg.........lhysaLfalGlvLFVitfllNi ++ +A f + + ++g+ + +++ +hy ++++ + L lN+ NP_036459. 865 LVISDIMALHFFFLVKDYGswldigtsiSHYVIVMSMTIFL----VFLNG 910 laryiirrlrrkygk<-* la+++++++ r gk NP_036459. 911 LAQLLTTKKLRLCGK 925 COG2233: domain 1 of 1, from 497 to 926: score -346.8, E = 20 *->m.llatalrsvllsmsdsampstmtksdlvygvddrp.pllkllllG ll +a + ++ ++p + y v +++++ + l+++ NP_036459. 497 FfLLIQACPWTYYVYGLLPLP-------IWYAVLREFqVIQDLVVSV 536 LQHllAMFgatVlVPLivGlalgLaaedlayLIsmsLf.....asGiaTL L+ l F++ l + +G + s+f + ++G+ + NP_036459. 537 LTYPLSHFVGY-LLAFTLGIEVLVL----------SFFyrymlTAGLTAF 575 l....QtlitgRpfGiglPivLGsSFAFvgPmIaaGglgkegGa..diea + + t+ + ++++ + ++ F ++ + ++ G ++di+ NP_036459. 576 AawpfLTRLWT---RAKMTSLSWTFFSLLLAVFPL---MPVVGRkpDISL 619 amgGifgaglvygviglLisrfgtgdrLkrlfPPvVtGpVImvIGLsLap +mg+ + ++l++ ++++ ++++ ++k + +V +++ Ls+ NP_036459. 620 VMGAGLLVLLLSLCVVTSLMKRKDS-FIKEEL--LVHLLQVLSTVLSMYV 666 VAikmagGgeaamasgnpdfgslenLlLalvVLliilllnrfgkGfl..r V ++ + + +g l n +++ ++L+ l++ + ++ l +r NP_036459. 667 VYSTQSSLL---RKQG----LPLMNQIISWATLASSLVVPLLSSPVLfqR 709 lipILiGlvvGYvlAlfmGlvdfdsalveaapwfalPtpfyfGaPYtpaF l +IL+ l Y+l ++ ++a +f l+ + NP_036459. 710 LFSILLSLMSTYLL------LST----GYEA-LFPLV--LS--------- 737 nwgaIltmlpvalvtivEhvGditAtgkv........tgkpllg..PeYk +++v + + E++ + +k + ++ + +++ ++++ + +Y NP_036459. 738 ------CLMFVWINIEQETLQQSGVCCKQkltsiqfsYNTDITQfrQLYL 781 pgLhrGllaDGlatllAGlfGgfPnTTFaqNiGvvalTgVaSryVivwaA +++r+++ l+ +l + f g +n +aS + + a+ NP_036459. 782 DDIRRAFF---LVFFLVTAFFGTGN--------------IASINSFDLAS 814 vililLGlfPKfaallqs....IPsPVLGGamivlFGmIAasGiriLira v + l ++P++++ l + + IP VL +m+ A+ +++ + NP_036459. 815 VYCFLTVFSPFMMGALMMwkilIP-FVL--VMC------AFEAVQ--LTT 853 kvdlsknRNLlIvAvsL..glGlGgaavPpeflaglPavl...rplllsG ++ L ++ +++++++ l +++ + ++ ++l+ ++++++ NP_036459. 854 QLSS---KSLFLIVLVIsdIMALHFFFL-VKDYG---SWLdigTSISHYV 896 ialgaitAIvLNllLpgrrrnpiveerreeksvtaeaaeealkkea<-* i++ + I+L +L+ + + + + ++ +l++ + NP_036459. 897 IVMS--MTIFL-VFLN---------GLAQ----LLTTKKLRLCGKP 926 COG0344: domain 1 of 1, from 759 to 926: score -139.4, E = 39 *->MeaasNivMlllvillivllaYLlGSIpfgvilaKlfkgvDiRkvGS ++ l+ i ++Y ++ + + +++ DiR NP_036459. 759 -KQ------KLTSIQ----FSY-----NTDITQFRQLYLDDIR---- 785 gNpGATNvlRvlkKGkkAKkaAilVlllDilKGflAVllarllyEslgld R++ +lV++l ++A++++ ++ ++ NP_036459. 786 ---------RAF----------FLVFFL-----VTAFFGTGNIA---SIN 808 pyllasnyqqyiLtYlvaiAAvLGHcfPiFfkFkGGKGVATalGvllv.. ++ las ++++v f++F+ +G+l + + NP_036459. 809 SFDLAS---------VYCFLTV----FSPFM-----------MGALMMwk 834 .lspwlaLitlltwLviflltkyvSLaSlvaaliatallvlvppldygyp l+p + ++++ ++ + + L+S+ +l ++ ++ +++l++ NP_036459. 835 iLIPFVLVMCAFEAVQLT-----TQLSSKSLFL-IVLVISDIMALHFFFL 878 vnkvFntplf.i.YlnewygylfpvlllaGlailviyRHreNIrrLlaGt v+ ++ +++ y+ +++++ i++++ ++ Ll+ + NP_036459. 879 VK----DYGSwLdIGTSISHYVIVMSMT----IFLVFL--NGLAQLLTTK 918 ErKvgekn<-* ++ +k NP_036459. 919 KLRLCGKP 926 COG0531: domain 1 of 1, from 466 to 928: score -164.4, E = 38 *->ssalrkkLG...lwdlvalgigamiGaGifalpgtaaalagpaaila +s+l k +++ ++ +l + ++ +Gi++++ +++++ +++ NP_036459. 466 HSNLIKGVSkevKKPSHLLPCSFVA-IGILVAFFLLIQAC----PWT 507 wllaglivlliAlsyaelssaiapelslaGGvYtYarralG.fagfltgw + + gl+ l+i ++ + i v + + l +f+g+l ++ NP_036459. 508 YYVYGLLPLPIWYAVLREFQVI------QDLVVSVLTYPLShFVGYLLAF 551 lyllsyiigpaii.........alaavsyl.slfpggfgasfgialptwl ++ +++++ +++ + + +a+aa+ +l+ l + ++ NP_036459. 552 TLGIEVLVLSFFYrymltagltAFAAWPFLtRLWTR-------AKMTSLS 594 gillggaqvlivivllllftllnllGvklsgrlntigteSkrvalivipl ++++ +ll++f l ++G k+ l++ ++ l+v++l NP_036459. 595 WTFFS--------LLLAVFPLMPVVGRKPDISLVMGAG------LLVLLL 630 lifillgiilfasglgfvtanflgpsgngifvdVlpgglagpgfggvlag + +++ + + +f l ++ vl++ NP_036459. 631 SLCVVTSLMKR--KDSFIKEELL------------------VHLLQVLST 660 ailvgiffaFvGfeavatlaeEvknP.....erniPrAiilsllivgliY ++++ + + +t ++ ++ + + i A+++s l+v l+ NP_036459. 661 VLSM--YVVY------STQSSLLRKQglplmNQIISWATLASSLVVPLLS 702 ilvsvalvgggdwsevvpsselassaapangrkvanvfalavaatallG. v + + + s ++ + +++ + +a+++l+ + NP_036459. 703 SPVLFQRLF------SILLSLMSTYLLLST---------GYEALFPLVLs 737 .wgaiiisvgal.............lsllgsllawilsasRvlyamArdG + ++i + + ++++ +++ s+ +s + +++ R ly + NP_036459. 738 cLMFVWINIEQEtlqqsgvcckqklTSIQFSYNTD-ITQFRQLYLDDIRR 786 ilPkffskvnprfrisltPvialiltgilsallallfplvslafsvltll + f v + f+ t ia i ++ l+++ +l + fs +++ NP_036459. 787 AFFLVFFLVTAFFG---TGNIASINSFDLASVYCFLTV-----FSPFMMG 828 afla..vllaylvlrialkklkpdlrrpgkkekkafrrpgvg.vlpilgi a ++ ++l++ +++++a +++ ++ ++ +l +l i NP_036459. 829 ALMMwkILIPFVLVMCAF----EAVQLT-------TQLSSKSlFLIVLVI 867 alclyallyssglp..........lilgvilvalGllilyllyarklpsd ++ l++++ ++ ++ + ++ i ++v+ + i+++++ + NP_036459. 868 SDIMA-LHFFFLVKdygswldigtSISHYVIVMSM-TIFLVFLNG----- 910 qsrlilssflhkkevedeeveevlepelasaeakaav<-* l + l +++ + k+ + NP_036459. 911 ---------LAQL----------LTTKKLRLCGKPKS 928 COG0628: domain 1 of 1, from 584 to 929: score -156.4, E = 5.6 *->mlmspairrllkpvvlrllvlllillllllflylfqplllplllAlv + + l++ +++ lll++ l +++ ++ l+ ++l+ NP_036459. 584 LWTRAKMTSLSW----TFFSLLLAVFPLMPVVGRKPDISLVMGAGLL 626 layllnPvvrwLerklgipRplavllvllllllllallllllvptlvgid + l vv L + ++ + ++ l++ ll +l ++l ++v + NP_036459. 627 VLLLSLCVVTSLMK-RKDS-FIKEELLVHLLQVLSTVLSMYVV-----YS 669 qlgqlirnnlPqlnnllqqllawlpnigllqlslyasldeliqqlisnrl + +l+ +++++l +++ ++ ++ +s + + l + NP_036459. 670 TQSSLL-------RKQGLPLMNQIISW-ATLASSLVVPLLSSPVLFQ--- 708 aailgsilssllnllgrqvknllglivslllvllllfffLldgeklkegi ++s ll+l + +ll ++ + +l++l+l +++ + +++ NP_036459. 709 -----RLFSILLSLMS---TYLLLSTGYEALFPLVLSCLMFVWINIEQET 750 ls...........llPsrlyrprvkrilselnaslgnyirGq.vlvalii l++++ +++ + + +y + ++++ + +++ ++ + +lv ++ NP_036459. 751 LQqsgvcckqkltSIQ-FSYNTDITQFRQLYLDDIRRAFFLVfFLVTAFF 799 Gvlsgigllllgvpy..........alllallagllnlIPyiGaviiwiP G + + + + + + ++ +++al+++ lIP++ + ++ NP_036459. 800 GTGNIASINSFDLASvycfltvfspFMMGALMMWKI-LIPFVLVMCA--- 845 aliyalltggglatwggllvlivflviqqlednvLrPklmgkrlg..... ++ l+t l +++ l+++++++ ++ ++ +l++++ + + + NP_036459. 846 FEAVQLTTQ--L-SSKSLFLIVLVISDIMALHFF---FLVKDYGSwldig 889 ..LhPllillsllgGgslfGfvGlilgpPllavlkalldaylrgdiaeli ++++ +i s+ ++ l++l+ l + + NP_036459. 890 tsISHYVIVMSMTIF---------------LVFLNGLAQLLTT------- 917 fkklaeqlgeees<-* kkl+ +++ + NP_036459. 918 -KKLRLCGKPKSH 929 COG0839: domain 1 of 1, from 782 to 929: score -91.1, E = 23 *->mmietlaFylfaalaiasalgVVlakNpvYSalyLilsllsiAglf. +i+ +F++f +++ ++ g + + N + L+++ +++ ++ + NP_036459. 782 DDIRRAFFLVFFLVTAFFGTGNIASINSF----DLASVYCFLTVFSp 824 fllgAeFlgvlqviVYvGAVmVLflFvvMmlnigveeikeeerrylssiv f++gA l++ +++ f+ v+ +++ + +++++++ NP_036459. 825 FMMGA--LMMWKILI-------PFVLVMCAFEA--VQLTTQLSSKS---- 859 gllvapvaLvlililsivyilialpsplgiaaadinktgNlkaiGavLFt L+li++++ +++ +++ +++ + +iG ++ + NP_036459. 860 --------LFLIVLVISDIMALHFFFLVKDYG-------SWLDIGTSI-S 893 dYLlpFEl.asvLLLvAmVgAIaLarrkrlgrkktdrkkqdekqktk<-* Y+++ +++++ L ++ A +L+ +k+ + k k+ NP_036459. 894 HYVIVMSMtIFLVFLNGL--AQLLTTKKL---------RLCGKPKSH 929 COG2814: domain 1 of 1, from 584 to 929: score -286.7, E = 17 *->masstkaqkskklallallaLAlaaFaiGttEFvpvGLLpdiAadlg + +k+ +++ + ++L la+F +L+p + + + NP_036459. 584 LWTRAKMTSLS----WTFFSLLLAVF----------PLMPVVGRKPD 616 vsiaa.AGqLislYAlgvalgaPlLtlltarleRKrlLLgllalFivsNl +s +++AG+L+ l +l v+ t+ + RK ++ +l + ++ NP_036459. 617 ISLVMgAGLLVLLLSLCVV---------TSLMKRKDSFIKEELLVHLLQV 657 lsAlApnfalL....llaRi..lsAlahGvFwviaaalAariVppekrgr ls + + + ++++++ l R ++l + + w a+lA+++V p NP_036459. 658 LSTVLSMYVVYstqsSLLRKqgLPLMNQIISW---ATLASSLVVPLLSSP 704 AlaliftGltlAlvlGvPLGtflGqlfGWRaaFlaiallallvllllarl l + + + l+l+ t+l G a F + +l+ l ++++ + NP_036459. 705 VLFQRLFSILLSLMS-----TYLLLSTGYEALFPL--VLSCLMFVWINIE 747 LPsipgsa....raekpgsl.....rsqlrllrrprvllillatilwigG +++s + + +++++ +++ +q+r l ++ ++ + ++++++ NP_036459. 748 QETLQQSGvcckQKLTSIQFsyntdITQFRQLYLDDIRRAFFLVFFLVTA 797 hFtlYTYiaPfLqevaGfsgatvtllLLvfGlagivGnllgGrladrlGp +F ++a +++ +++ ++ + ++++ ++ l + NP_036459. 798 FFGT--------GNIASINSFDLASVYCFL-------TVFSPFMMGAL-M 831 rrtllgvllllalvlllLplaags..lilalaalflWGlaafsagpalQt + +l+ ++l ++++ ++ l+++ +++ l+l++l++ ++a + + NP_036459. 832 MWKILIPFVLVMCAFEAVQLTTQLssKSLFLIVLVISDIMALHFFFLVKD 881 rvarlapRdaadvaaslnvaAfNlGialGAalGGlvldrglGlaalpwvG + + l + s +v ++ + i l ++l++ NP_036459. 882 YGSWLDI----GTSISHYVIVMSMTIFL------VFLNG----------- 910 AaLvllAlllallaarskkktaaepsll<-* la+l ++k + +p NP_036459. 911 ---------LAQLLTTKKLRLCGKPKSH 929 COG3090: domain 1 of 1, from 760 to 930: score -81.1, E = 80 *->MsvlhrvwamyemetilfslklldlvtfinklleiLlalllilmvll + l + y+ + f ++l +++++ ++ ++++ + NP_036459. 760 -QKLTSIQFSYNTDITQF-RQL-----YLDDIRRAFFLVFFLVTAFF 799 vfwnVvlRylGrlygfnssiswseELaryLFiwl...vfLGisyavkkng ++n+ + + ++ +++y+F ++ +++++G+ +k NP_036459. 800 GTGNIASI------------NSFDLASVYCFLTVfspFMMGALMMWK--- 834 HvrVdv.LvnlLpeklrkvlqlvatllvLifagliivgsyrYWHFiEidw + + + Lv + e ++ +ql l+Li + + + ++ NP_036459. 835 -ILIPFvLVMCAFEAVQLTTQLSSKSLFLIVLVISDIMAL--------HF 875 aqtsdimPmlFlagilnqgspalGiprgliyaalPvGfvLlafrflqili + + + ++ l i ++ ++++ +++ +++ fl l NP_036459. 876 FFL------------VKDYGSWLDIGTSISHYVIVMSMT-IFLVFLNGLA 912 knikekldrlialglvdeavealk<-* +++++ + ++ ++ + + NP_036459. 913 QLLTT------KKLRLCGKPKSHF 930 // hmmpfam - search a single seq against HMM database HMMER 2.1.1 (Dec 1998) Copyright (C) 1992-1998 Washington University School of Medicine HMMER is freely distributed under the GNU General Public License (GPL). - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /data/patterns/cogs/cogs.hmm-f Sequence file: NP_036459.1.fa - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: NP_036459.1 phosphatidylinositol glycan, class N; [Homo sapiens]. Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- COG1524 127.7 1.7e-34 1 COG2076 3.7 17 1 COG3092 0.9 43 1 COG1277 0.6 51 1 COG0762 0.5 47 1 COG0531 0.1 24 1 COG0559 0.0 29 1 COG2510 0.0 77 1 COG1030 -0.5 58 1 COG2703 -0.6 92 1 COG1291 -0.6 77 1 COG1055 -0.8 80 1 COG0583 -0.9 99 1 COG0755 -1.0 74 1 COG2390 -1.0 54 1 COG2027 -1.1 55 1 COG2244 -1.1 79 1 COG1361 -1.5 70 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- COG0583 1/1 33 61 .. 289 317 .] -0.9 99 COG1291 1/1 291 307 .. 116 131 .. -0.6 77 COG3092 1/1 299 309 .. 145 155 .] 0.9 43 COG1524 1/1 8 342 .. 36 471 .. 127.7 1.7e-34 COG2076 1/1 481 504 .. 28 51 .. 3.7 17 COG1361 1/1 558 577 .. 1 20 [. -1.5 70 COG2510 1/1 590 605 .. 1 17 [. 0.0 77 COG2244 1/1 581 648 .. 441 510 .] -1.1 79 COG1030 1/1 614 648 .. 1 59 [. -0.5 58 COG0762 1/1 651 665 .. 1 15 [. 0.5 47 COG0531 1/1 599 670 .. 394 471 .. 0.1 24 COG1055 1/1 650 672 .. 444 466 .] -0.8 80 COG2390 1/1 740 755 .. 1 16 [. -1.0 54 COG0755 1/1 827 857 .. 323 354 .] -1.0 74 COG0559 1/1 829 868 .. 1 43 [. 0.0 29 COG2703 1/1 849 871 .. 1 23 [. -0.6 92 COG1277 1/1 898 920 .. 1 23 [. 0.6 51 COG2027 1/1 894 923 .. 1 41 [. -1.1 55 Alignments of top-scoring domains: COG0583: domain 1 of 1, from 33 to 61: score -0.9, E = 99 *->yrkrrelspavrafieflreelaaeaaal<-* +++ +l+p++r+++ f+++ l+a a+ NP_036459. 33 TPQFTPLPPPARRLVLFVADGLRADALYE 61 COG1291: domain 1 of 1, from 291 to 307: score -0.6, E = 77 *->kYP.dieleeieDpFlk<-* kYP+++++++++D+Flk NP_036459. 291 KYPqRVSAQQFDDAFLK 307 COG3092: domain 1 of 1, from 299 to 309: score 0.9, E = 43 *->kqLdktfLeel<-* +q d++fL e+ NP_036459. 299 QQFDDAFLKEW 309 COG1524: domain 1 of 1, from 8 to 342: score 127.7, E = 1.7e-34 *->ivllillylnsivnkfllaglvidadpsqdtfritadpfkklvlivi ++l ++ + +si+++++ ++lv+++ p +++ ++ + +lvl+v NP_036459. 8 GLLIHFVFFASIFDIYFTSPLVHGMTPQFTPLPPP---ARRLVLFVA 51 DGLradlidalkeegllpkleelnpilrsggmniytlecitpSFPTlTlp DGLrad ++ l+e g + ++p++r m + + ++++++ PT+++p NP_036459. 52 DGLRADALYELDENG-----NSRAPFIRNIIMHEGSWGISHTRVPTESRP 96 nhktliTGlyPdehgivsnvlyDpeedEeymklsgarvlfndldlkplvk +h +li+G+y+d++++ + ++++p +++++lfn+++++ + NP_036459. 97 GHVALIAGFYEDVSAVAKGWKENP---------VEFDSLFNESKYTWS-- 135 idartalkdvplvqdelfdrgkdllkvaffpwlqsevfdpflkeslprgr ++++ p++++ +++ + ++ + +e+f + ++ +++ NP_036459. 136 ---WGSPDILPMFAKGASGDHV----YTYSYDAKREDFGA--QDATKLDT 176 DtvivatffyfdekqadhqldlksSFLkddysvlndglllrenedpdraY ++f + +++ h + n l +ne+ NP_036459. 177 ------WVFDNVKDFFHHARN-------------NQSLFSKINEEKI--- 204 dlvllhfpniDhaGHkyGpdSeedfiYdsyrkavkevDsllsdLleslqk +++lh ++iD+ GH ++p S++ y ++k+vD+ +++++ + NP_036459. 205 -VFFLHLLGIDTNGHAHRPSSRD------YKHNIKKVDDGVKEIVSMFNH 247 h.eldddtlviivsDHGqsqvkskVvmnEygqrsgieavSDgavvshggl + ++d +t +i++sDHG m++ g shg NP_036459. 248 FyGNDGKTTFIFTSDHG---------MTDWG--------------SHGA- 273 rgVYvyFqPamsysekeleslrflfgvlkaflredeeeYlakpvsgnlik ++ e++++++++g++ +++ + a+ + ++++k NP_036459. 274 ------------GHPSETLTPLVTWGAGIKYPQRVS----AQQFDDAFLK 307 nldegfgvqhfkqqikiillnerlgdkfdifmpipkngve<-* +++ +++ ++ q++i++l+ l++ +p p n+v+ NP_036459. 308 EWRLENWKRLDVNQADIAPLMTSLIG-----VPFPLNSVG 342 COG2076: domain 1 of 1, from 481 to 504: score 3.7, E = 17 *->tklwpslltivgiilSFylLslAl<-* ++l+p ++++gi+++F+lL++A+ NP_036459. 481 SHLLPCSFVAIGILVAFFLLIQAC 504 COG1361: domain 1 of 1, from 558 to 577: score -1.5, E = 70 *->ieyseflrwmmraitmlivl<-* + +s+f+r+m +a++ ++++ NP_036459. 558 LVLSFFYRYMLTAGLTAFAA 577 COG2510: domain 1 of 1, from 590 to 605: score 0.0, E = 77 *->MmemdayifwALLaAfF<-* m ++ + f+ LL A+F NP_036459. 590 -MTSLSWTFFSLLLAVF 605 COG2244: domain 1 of 1, from 581 to 648: score -1.1, E = 79 *->lgglsaklkkilklliaallmalgivvlavllllllillaaaglvga l++l+ ++k+ + l + ++++l++v+ ++ + + +++ g+ NP_036459. 581 LTRLWTRAKMTS--LSWTFFSLLLAVFPLMPVVGRKPDISLVMGAGL 625 lillgalvavglavrdylllrls<-* l+ll++l++v + ++++++ + NP_036459. 626 LVLLLSLCVVTSLMKRKDSFIKE 648 COG1030: domain 1 of 1, from 614 to 648: score -0.5, E = 58 *->maslRrFlialmkillLllLllallaaqaeaqklretttttAGEqPV ++ + ++m+++lL lLl++ + + ++k NP_036459. 614 KPDIS----LVMGAGLLVLLLSLCVVTSLMKRK-------------- 642 PGKADFESLVKE<-* +S +KE NP_036459. 643 ------DSFIKE 648 COG0762: domain 1 of 1, from 651 to 665: score 0.5, E = 47 *->msslifiLstllsLY<-* ++ l++ Lst+ls Y NP_036459. 651 LVHLLQVLSTVLSMY 665 COG0531: domain 1 of 1, from 599 to 670: score 0.1, E = 24 *->allallfplvsla.......fsvltllaflavllaylvlrialkklk +ll+++fpl+++++++++ + ++++ l +l++ l+++ + ++ NP_036459. 599 SLLLAVFPLMPVVgrkpdisLVMGAGLLVLLLSLCVVTSLMKR---- 641 pdlrrpgkkekkafrrpgvgvlpilgialclyallyss<-* d ++ ++v +l +l+++l++y ++ys+ NP_036459. 642 KDSFIK--------EELLVHLLQVLSTVLSMY-VVYST 670 COG1055: domain 1 of 1, from 650 to 672: score -0.8, E = 80 *->livtlpsllvtllyLyirysvll<-* l+v l+++l t+l+ y++ys+++ NP_036459. 650 LLVHLLQVLSTVLSMYVVYSTQS 672 COG2390: domain 1 of 1, from 740 to 755: score -1.0, E = 54 *->MdqlieaqreldpRSG<-* M +i +++e+++ SG NP_036459. 740 MFVWINIEQETLQQSG 755 COG0755: domain 1 of 1, from 827 to 857: score -1.0, E = 74 *->rgkkaawltvagfallmiAyfgvnlvleglhs<-* +g ++w ++ f+l+m A+ +v l + +l+s NP_036459. 827 MGALMMWKILIPFVLVMCAFEAVQLTT-QLSS 857 COG0559: domain 1 of 1, from 829 to 868: score 0.0, E = 29 *->rwailallyllalvpaavlmsdllqlllngltlgliyallALG<-* +++++ +l++++lv+ a++ ++l ++ + + +l ++ l+++ NP_036459. 829 ALMMWKILIPFVLVMCAFEAVQL---TTQLSSKSLFLIVLVIS 868 COG2703: domain 1 of 1, from 849 to 871: score -0.6, E = 92 *->VSLiKNLSSKYLLKiYFmCGEim<-* V L LSSK L i + +im NP_036459. 849 VQLTTQLSSKSLFLIVLVISDIM 871 COG1277: domain 1 of 1, from 898 to 920: score 0.6, E = 51 *->nmmnsllaiarkelrsivrskrf<-* +m + +++++ l++ +++k++ NP_036459. 898 VMSMTIFLVFLNGLAQLLTTKKL 920 COG2027: domain 1 of 1, from 894 to 923: score -1.1, E = 55 *->mkkvlllyfsllpvaltSstPaklaqllaslpagaqsdrLe<-* +v+ ++ + ++v+l + laqll +++ rL+ NP_036459. 894 -HYVIVMSMTIFLVFLNG-----LAQLLTTKKL-----RLC 923 //