analysis of sequence from TRYP10.0.001875_6.fa ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ >TRYP10.0.001875_6 MRNCQPASLR ETSAMGEAAQ PRGTIGSVST ETATVRDEGR VWRKVLYTRQ PYEDNYVDPQ QFLQDLRQNV NVATYEYNKV VLDTFVVIQQ FSFVVFYLFV FSMMLSGRVD ECALMWVNAT LFTLAFVFCI VVQRQQAVDR GEIPTPFTHY LMGLCRQGIP LVGVLILLSP VLQTLTVAYS NDTIVTLSSL SMFVHVLLTD YNYLNCYSER YQQNTAVNAA TFGIILIASR IQRVFQSGAL IMFGILCFTL SPIPRHNLKH VSLRAHVVLT FTICALAIYF LMEVPVFALL YCVVVVVISV VIPFFFVKLH GSMKDQINGP WDEAKPTNSA AAVEWANAGM LQ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ sec.str. with predator > TRYP10.0.001875_6 . . . . . 1 MRNCQPASLRETSAMGEAAQPRGTIGSVSTETATVRDEGRVWRKVLYTRQ 50 ______HHHHHHH_____________EEEEEEEEE______HHHHHHH__ . . . . . 51 PYEDNYVDPQQFLQDLRQNVNVATYEYNKVVLDTFVVIQQFSFVVFYLFV 100 __________HHHHHHHHH___EEE___HHHHHHHEEEEE__HHHHHHHH . . . . . 101 FSMMLSGRVDECALMWVNATLFTLAFVFCIVVQRQQAVDRGEIPTPFTHY 150 HHH_______HHHHHHHHHHHHHHHHHHHHHHHHHHHHH__________H . . . . . 151 LMGLCRQGIPLVGVLILLSPVLQTLTVAYSNDTIVTLSSLSMFVHVLLTD 200 HHHHH_______EEEEEE_____EEEEEE_____EEEE____EEEEEEE_ . . . . . 201 YNYLNCYSERYQQNTAVNAATFGIILIASRIQRVFQSGALIMFGILCFTL 250 _________HHHHHHHHHHHHHHEEEEHHHHHHHHH___EEEEEEEEEE_ . . . . . 251 SPIPRHNLKHVSLRAHVVLTFTICALAIYFLMEVPVFALLYCVVVVVISV 300 _______EEEHHHHHHHHHHHHHHHHHHHHHH_HHHHHHHHHHHHHEEEE . . . . 301 VIPFFFVKLHGSMKDQINGPWDEAKPTNSAAAVEWANAGMLQ 342 EHHHHHHH____________________HHHHHHHHHHH___ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ method : 1 alpha-contents : 10.9 % beta-contents : 79.8 % coil-contents : 9.3 % class : beta method : 2 alpha-contents : 7.1 % beta-contents : 73.9 % coil-contents : 19.0 % class : beta ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ GPI: learning from metazoa 0.38 -0.06 0.00 0.00 0.00 0.00 -12.00 0.00 0.00 -4.21 -1.05 -12.00 -12.00 0.00 -12.00 0.00 -52.95 -2.67 0.00 0.00 0.00 0.00 0.00 -20.00 0.00 -0.09 -4.21 -1.05 -12.00 -12.00 0.00 0.00 0.00 -52.03 ID: TRYP10.0.001875_6 AC: xxx Len: 342 1:I 330 Sc: -52.03 Pv: 2.502579e-01 NO_GPI_SITE GPI: learning from protozoa -5.31 0.00 0.00 0.00 0.00 0.00 -20.00 0.00 0.00 -3.75 -4.77 -12.00 -12.00 0.00 0.00 0.00 -57.84 1.78 -0.03 -0.12 0.00 0.00 0.00 -12.00 -0.03 0.00 -3.75 -4.77 -12.00 -12.00 0.00 -12.00 0.00 -54.93 ID: TRYP10.0.001875_6 AC: xxx Len: 342 1:I 328 Sc: -54.93 Pv: 1.775960e-01 NO_GPI_SITE ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ # SignalP euk predictions # name Cmax pos ? Ymax pos ? Smax pos ? Smean ? TRYP10.0.00 0.839 138 Y 0.735 138 Y 0.977 295 Y 0.301 N # SignalP gram- predictions # name Cmax pos ? Ymax pos ? Smax pos ? Smean ? TRYP10.0.00 0.545 289 Y 0.326 135 N 0.936 121 Y 0.294 N # SignalP gram+ predictions # name Cmax pos ? Ymax pos ? Smax pos ? Smean ? TRYP10.0.00 0.733 278 Y 0.422 138 Y 0.996 123 Y 0.357 N ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ low complexity regions: SEG 12 2.2 2.5 >TRYP10.0.001875_6 1-84 MRNCQPASLRETSAMGEAAQPRGTIGSVST ETATVRDEGRVWRKVLYTRQPYEDNYVDPQ QFLQDLRQNVNVATYEYNKVVLDT fvviqqfsfvvfylfvfsmml 85-105 106-283 SGRVDECALMWVNATLFTLAFVFCIVVQRQ QAVDRGEIPTPFTHYLMGLCRQGIPLVGVL ILLSPVLQTLTVAYSNDTIVTLSSLSMFVH VLLTDYNYLNCYSERYQQNTAVNAATFGII LIASRIQRVFQSGALIMFGILCFTLSPIPR HNLKHVSLRAHVVLTFTICALAIYFLME vpvfallycvvvvvisvvipfffv 284-307 308-342 KLHGSMKDQINGPWDEAKPTNSAAAVEWAN AGMLQ low complexity regions: SEG 25 3.0 3.3 >TRYP10.0.001875_6 1-79 MRNCQPASLRETSAMGEAAQPRGTIGSVST ETATVRDEGRVWRKVLYTRQPYEDNYVDPQ QFLQDLRQNVNVATYEYNK vvldtfvviqqfsfvvfylfvfs 80-102 103-283 MMLSGRVDECALMWVNATLFTLAFVFCIVV QRQQAVDRGEIPTPFTHYLMGLCRQGIPLV GVLILLSPVLQTLTVAYSNDTIVTLSSLSM FVHVLLTDYNYLNCYSERYQQNTAVNAATF GIILIASRIQRVFQSGALIMFGILCFTLSP IPRHNLKHVSLRAHVVLTFTICALAIYFLM E vpvfallycvvvvvisvvipfffv 284-307 308-342 KLHGSMKDQINGPWDEAKPTNSAAAVEWAN AGMLQ low complexity regions: SEG 45 3.4 3.75 >TRYP10.0.001875_6 1-160 MRNCQPASLRETSAMGEAAQPRGTIGSVST ETATVRDEGRVWRKVLYTRQPYEDNYVDPQ QFLQDLRQNVNVATYEYNKVVLDTFVVIQQ FSFVVFYLFVFSMMLSGRVDECALMWVNAT LFTLAFVFCIVVQRQQAVDRGEIPTPFTHY LMGLCRQGIP lvgvlillspvlqtltvaysndtivtlssl 161-199 smfvhvllt 200-257 DYNYLNCYSERYQQNTAVNAATFGIILIAS RIQRVFQSGALIMFGILCFTLSPIPRHN lkhvslrahvvltfticalaiyflmevpvf 258-309 allycvvvvvisvvipfffvkl 310-342 HGSMKDQINGPWDEAKPTNSAAAVEWANAG MLQ low complexity regions: XNU # Score cutoff = 21, Search from offsets 1 to 4 # both members of each repeat flagged # lambda = 0.347, K = 0.200, H = 0.664 >TRYP10.0.001875_6 MRNCQPASLRETSAMGEAAQPRGTIGSVSTETATVRDEGRVWRKVLYTRQPYEDNYVDPQ QFLQDLRQNVNVATYEYNKVVLDTFVVIQQFSFVVFYLFVFSMMLSGRVDECALMWVNAT LFTLAFVFCIVVQRQQAVDRGEIPTPFTHYLMGLCRQGIPLVGVLILLSPVLQTLTVAYS NDTIVTLSSLSMFVHVLLTDYNYLNCYSERYQQNTAVNAATFGIILIASRIQRVFQSGAL IMFGILCFTLSPIPRHNLKHVSLRAHVVLTFTICALAIYFLMEVPVFALLYCvvvvvisv vipfffVKLHGSMKDQINGPWDEAKPTNSAAAVEWANAGMLQ 1 - 292 MRNCQPASLR ETSAMGEAAQ PRGTIGSVST ETATVRDEGR VWRKVLYTRQ PYEDNYVDPQ QFLQDLRQNV NVATYEYNKV VLDTFVVIQQ FSFVVFYLFV FSMMLSGRVD ECALMWVNAT LFTLAFVFCI VVQRQQAVDR GEIPTPFTHY LMGLCRQGIP LVGVLILLSP VLQTLTVAYS NDTIVTLSSL SMFVHVLLTD YNYLNCYSER YQQNTAVNAA TFGIILIASR IQRVFQSGAL IMFGILCFTL SPIPRHNLKH VSLRAHVVLT FTICALAIYF LMEVPVFALL YC 293 - 306 vvvvvisv vipfff 307 - 342 VKLH GSMKDQINGP WDEAKPTNSA AAVEWANAGM LQ low complexity regions: DUST >TRYP10.0.001875_6 MRNCQPASLRETSAMGEAAQPRGTIGSVSTETATVRDEGRVWRKVLYTRQPYEDNYVDPQ QFLQDLRQNVNVATYEYNKVVLDTFVVIQQFSFVVFYLFVFSMMLSGRVDECALMWVNAT LFTLAFVFCIVVQRQQAVDRGEIPTPFTHYLMGLCRQGIPLVGVLILLSPVLQTLTVAYS NDTIVTLSSLSMFVHVLLTDYNYLNCYSERYQQNTAVNAATFGIILIASRIQRVFQSGAL IMFGILCFTLSPIPRHNLKHVSLRAHVVLTFTICALAIYFLMEVPVFALLYCVVVVVISV VIPFFFVKLHGSMKDQINGPWDEAKPTNSAAAVEWANAGMLQ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ coiled coil prediction for TRYP10.0.001875_6 sequence: 342 amino acids, 0 residue(s) in coiled coil state . | . | . | . | . | . 60 MRNCQPASLR ETSAMGEAAQ PRGTIGSVST ETATVRDEGR VWRKVLYTRQ PYEDNYVDPQ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 -w border ---------- ---------- ---------- ---------- ---------- ---------- * 21 M'95 -w register ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~1 * 21 M'95 +w polar ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 MTK -w class ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 28 M'95 -w signif. ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 14 M'95 -w local . | . | . | . | . | . 120 QFLQDLRQNV NVATYEYNKV VLDTFVVIQQ FSFVVFYLFV FSMMLSGRVD ECALMWVNAT ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 -w border ---------- ---------- ---------- ---------- ---------- ---------- * 21 M'95 -w register 1111111111 1111111111 111~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 +w polar ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 MTK -w class ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 28 M'95 -w signif. ~~11111111 111111~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 14 M'95 -w local . | . | . | . | . | . 180 LFTLAFVFCI VVQRQQAVDR GEIPTPFTHY LMGLCRQGIP LVGVLILLSP VLQTLTVAYS ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 -w border ---------- ---------- ---------- ---------- ---------- ---------- * 21 M'95 -w register ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 +w polar ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 MTK -w class ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 28 M'95 -w signif. ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 14 M'95 -w local . | . | . | . | . | . 240 NDTIVTLSSL SMFVHVLLTD YNYLNCYSER YQQNTAVNAA TFGIILIASR IQRVFQSGAL ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 -w border ---------- ---------- ---------- ---------- ---------- ---------- * 21 M'95 -w register ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 +w polar ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 MTK -w class ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 28 M'95 -w signif. ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 14 M'95 -w local . | . | . | . | . | . 300 IMFGILCFTL SPIPRHNLKH VSLRAHVVLT FTICALAIYF LMEVPVFALL YCVVVVVISV ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 -w border ---------- ---------- ---------- ---------- ---------- ---------- * 21 M'95 -w register ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 M'95 +w polar ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 21 MTK -w class ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 28 M'95 -w signif. ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ * 14 M'95 -w local . | . | . | . | VIPFFFVKLH GSMKDQINGP WDEAKPTNSA AAVEWANAGM LQ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~ ---------- ---------- ---------- ---------- -- ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ prediction of transmembrane regions with toppred2 *********************************** *TOPPREDM with eukaryotic function* *********************************** TRYP10.0.001875_6.fa.___inter___ is a single sequence Using hydrophobicity file: /bio_software/2D/toppredm/lib/Engelman-Steitz.scale Using cyt/ext file: /bio_software/2D/toppredm/lib/Cyt-Ext.prok Using sequence file: TRYP10.0.001875_6.fa.___inter___ (1 sequences) MRNCQPASLRETSAMGEAAQPRGTIGSVSTETATVRDEGRVWRKVLYTRQ PYEDNYVDPQQFLQDLRQNVNVATYEYNKVVLDTFVVIQQFSFVVFYLFV FSMMLSGRVDECALMWVNATLFTLAFVFCIVVQRQQAVDRGEIPTPFTHY LMGLCRQGIPLVGVLILLSPVLQTLTVAYSNDTIVTLSSLSMFVHVLLTD YNYLNCYSERYQQNTAVNAATFGIILIASRIQRVFQSGALIMFGILCFTL SPIPRHNLKHVSLRAHVVLTFTICALAIYFLMEVPVFALLYCVVVVVISV VIPFFFVKLHGSMKDQINGPWDEAKPTNSAAAVEWANAGMLQ (p)rokaryotic or (e)ukaryotic: e Charge-pair energy: 0 Length of full window (odd number!): 21 Length of core window (odd number!): 11 Number of residues to add to each end of helix: 1 Critical length: 60 Upper cutoff for candidates: 1 Lower cutoff for candidates: 0.6 Total of 2 structures are to be tested Candidate membrane-spanning segments: Helix Begin End Score Certainity 1 87 107 2.077 Certain 2 112 132 2.024 Certain 3 158 178 1.658 Certain 4 181 201 1.288 Certain 5 211 231 0.766 Putative 6 234 254 2.055 Certain 7 264 284 1.771 Certain 8 287 307 2.327 Certain ---------------------------------------------------------------------- Structure 1 Transmembrane segments included in this structure: Segment 1 2 3 4 5 6 7 8 Loop length 86 4 25 2 9 2 9 2 35 K+R profile + 3.00 1.00 3.00 3.00 1.00 0.00 2.00 0.00 CYT-EXT prof 0.71 - - - - - - - - For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: 7.00 Tm probability: 0.41 -> Orientation: N-in Charge-difference over N-terminal Tm (+-15 residues): 0.00 (NEG-POS)/(NEG+POS): 0.0476 NEG: 11.0000 POS: 10.0000 -> Orientation: undecided CYT-EXT difference: 0.71 -> Orientation: N-out ---------------------------------------------------------------------- Structure 2 Transmembrane segments included in this structure: Segment 1 2 3 4 6 7 8 Loop length 86 4 25 2 32 9 2 35 K+R profile + 3.00 3.00 0.00 1.00 0.00 3.00 3.00 CYT-EXT prof 0.71 - - - - - - - For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: -1.00 Tm probability: 1.00 -> Orientation: N-out Charge-difference over N-terminal Tm (+-15 residues): 0.00 (NEG-POS)/(NEG+POS): 0.0476 NEG: 11.0000 POS: 10.0000 -> Orientation: undecided CYT-EXT difference: 0.71 -> Orientation: N-out ---------------------------------------------------------------------- "TRYP10" 342 87 107 #t 2.07708 112 132 #t 2.02396 158 178 #t 1.65833 181 201 #t 1.2875 211 231 #f 0.765625 234 254 #t 2.05521 264 284 #t 1.77083 287 307 #t 2.32708 ************************************ *TOPPREDM with prokaryotic function* ************************************ TRYP10.0.001875_6.fa.___inter___ is a single sequence Using hydrophobicity file: /bio_software/2D/toppredm/lib/Engelman-Steitz.scale Using cyt/ext file: /bio_software/2D/toppredm/lib/Cyt-Ext.prok Using sequence file: TRYP10.0.001875_6.fa.___inter___ (1 sequences) MRNCQPASLRETSAMGEAAQPRGTIGSVSTETATVRDEGRVWRKVLYTRQ PYEDNYVDPQQFLQDLRQNVNVATYEYNKVVLDTFVVIQQFSFVVFYLFV FSMMLSGRVDECALMWVNATLFTLAFVFCIVVQRQQAVDRGEIPTPFTHY LMGLCRQGIPLVGVLILLSPVLQTLTVAYSNDTIVTLSSLSMFVHVLLTD YNYLNCYSERYQQNTAVNAATFGIILIASRIQRVFQSGALIMFGILCFTL SPIPRHNLKHVSLRAHVVLTFTICALAIYFLMEVPVFALLYCVVVVVISV VIPFFFVKLHGSMKDQINGPWDEAKPTNSAAAVEWANAGMLQ (p)rokaryotic or (e)ukaryotic: p Charge-pair energy: 0 Length of full window (odd number!): 21 Length of core window (odd number!): 11 Number of residues to add to each end of helix: 1 Critical length: 60 Upper cutoff for candidates: 1 Lower cutoff for candidates: 0.6 Total of 2 structures are to be tested Candidate membrane-spanning segments: Helix Begin End Score Certainity 1 87 107 2.077 Certain 2 112 132 2.024 Certain 3 158 178 1.658 Certain 4 181 201 1.288 Certain 5 211 231 0.766 Putative 6 234 254 2.055 Certain 7 264 284 1.771 Certain 8 287 307 2.327 Certain ---------------------------------------------------------------------- Structure 1 Transmembrane segments included in this structure: Segment 1 2 3 4 5 6 7 8 Loop length 86 4 25 2 9 2 9 2 35 K+R profile + 3.00 1.00 3.00 3.00 1.00 0.00 2.00 0.00 CYT-EXT prof 0.71 - - - - - - - - For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: 7.00 Tm probability: 0.41 -> Orientation: N-in Charge-difference over N-terminal Tm (+-15 residues): 0.00 (NEG-POS)/(NEG+POS): 0.0476 NEG: 11.0000 POS: 10.0000 -> Orientation: undecided CYT-EXT difference: 0.71 -> Orientation: N-out ---------------------------------------------------------------------- Structure 2 Transmembrane segments included in this structure: Segment 1 2 3 4 6 7 8 Loop length 86 4 25 2 32 9 2 35 K+R profile + 3.00 3.00 0.00 1.00 0.00 3.00 3.00 CYT-EXT prof 0.71 - - - - - - - For CYT-EXT profile neg. values indicate cytoplasmic preference. K+R difference: -1.00 Tm probability: 1.00 -> Orientation: N-out Charge-difference over N-terminal Tm (+-15 residues): 0.00 (NEG-POS)/(NEG+POS): 0.0476 NEG: 11.0000 POS: 10.0000 -> Orientation: undecided CYT-EXT difference: 0.71 -> Orientation: N-out ---------------------------------------------------------------------- "TRYP10" 342 87 107 #t 2.07708 112 132 #t 2.02396 158 178 #t 1.65833 181 201 #t 1.2875 211 231 #f 0.765625 234 254 #t 2.05521 264 284 #t 1.77083 287 307 #t 2.32708 ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ SAPS. Version of April 11, 1996. Date run: Thu Feb 28 17:33:26 2002 File: /people/b_eisen/TRYP10.0.001875_6.fa.___saps___ ID TRYP10.0.001875_6 DE - number of residues: 342; molecular weight: 38.5 kdal 1 MRNCQPASLR ETSAMGEAAQ PRGTIGSVST ETATVRDEGR VWRKVLYTRQ PYEDNYVDPQ 61 QFLQDLRQNV NVATYEYNKV VLDTFVVIQQ FSFVVFYLFV FSMMLSGRVD ECALMWVNAT 121 LFTLAFVFCI VVQRQQAVDR GEIPTPFTHY LMGLCRQGIP LVGVLILLSP VLQTLTVAYS 181 NDTIVTLSSL SMFVHVLLTD YNYLNCYSER YQQNTAVNAA TFGIILIASR IQRVFQSGAL 241 IMFGILCFTL SPIPRHNLKH VSLRAHVVLT FTICALAIYF LMEVPVFALL YCVVVVVISV 301 VIPFFFVKLH GSMKDQINGP WDEAKPTNSA AAVEWANAGM LQ -------------------------------------------------------------------------------- COMPOSITIONAL ANALYSIS (extremes relative to: swp23s) A : 26( 7.6%); C : 8( 2.3%); D : 11( 3.2%); E : 12( 3.5%); F : 22( 6.4%) G : 15( 4.4%); H : 6( 1.8%); I : 19( 5.6%); K : 6( 1.8%); L : 36(10.5%) M : 11( 3.2%); N : 15( 4.4%); P : 14( 4.1%); Q : 20( 5.8%); R : 17( 5.0%) S : 20( 5.8%); T : 23( 6.7%); V++: 43(12.6%); W : 4( 1.2%); Y : 14( 4.1%) KR : 23 ( 6.7%); ED : 23 ( 6.7%); AGP : 55 ( 16.1%); KRED : 46 ( 13.5%); KR-ED : 0 ( 0.0%); FIKMNY : 87 ( 25.4%); LVIFM + : 131 ( 38.3%); ST : 43 ( 12.6%). -------------------------------------------------------------------------------- CHARGE DISTRIBUTIONAL ANALYSIS 1 0+0000000+ -00000-000 0+00000000 -0000+--0+ 00++0000+0 00--000-00 61 0000-0+000 00000-00+0 00-0000000 0000000000 0000000+0- -000000000 121 0000000000 000+0000-+ 0-00000000 00000+0000 0000000000 0000000000 181 0-00000000 000000000- 00000000-+ 0000000000 000000000+ 00+0000000 241 0000000000 0000+000+0 000+000000 0000000000 00-0000000 0000000000 301 0000000+00 000+-00000 0--0+00000 000-000000 00 A. CHARGE CLUSTERS. Positive charge clusters (cmin = 7/30 or 9/45 or 11/60): none Negative charge clusters (cmin = 7/30 or 9/45 or 11/60): none Mixed charge clusters (cmin = 11/30 or 15/45 or 18/60): 1) From 31 to 58: ETATVRDEGRVWRKVLYTRQPYEDNYVD -0000+--0+00++0000+000--000- quartile: 1; size: 28, +count: 5, -count: 6, 0count: 17; t-value: 4.01 * V: 4 (14.3%); E: 3 (10.7%); T: 3 (10.7%); D: 3 (10.7%); R: 4 (14.3%); Y: 3 (10.7%); B. HIGH SCORING (UN)CHARGED SEGMENTS. There are no high scoring positive charge segments. There are no high scoring negative charge segments. There are no high scoring mixed charge segments. There are no high scoring uncharged segments. C. CHARGE RUNS AND PATTERNS. pattern (+)| (-)| (*)| (0)| (+0)| (-0)| (*0)|(+00)|(-00)|(*00)| (H.)|(H..)| lmin0 4 | 4 | 5 | 58 | 8 | 8 | 10 | 10 | 10 | 13 | 6 | 8 | lmin1 5 | 5 | 7 | 71 | 10 | 10 | 13 | 12 | 12 | 16 | 8 | 9 | lmin2 6 | 6 | 8 | 79 | 11 | 11 | 14 | 14 | 14 | 18 | 9 | 11 | (Significance level: 0.010000; Minimal displayed length: 6) There are no charge runs or patterns exceeding the given minimal lengths. Run count statistics: + runs >= 3: 0 - runs >= 3: 0 * runs >= 3: 1, at 36; 0 runs >= 39: 0 -------------------------------------------------------------------------------- DISTRIBUTION OF OTHER AMINO ACID TYPES 1. HIGH SCORING SEGMENTS. __________________________________ High scoring hydrophobic segments: 2.00 (LVIFM) 1.00 (AGYCW) 0.00 (BZX) -2.00 (PH) -4.00 (STNQ) -8.00 (KEDR) Expected score/letter: -1.143 M_0.01= 37.40; M_0.05= 30.22 1) From 273 to 307: length= 35, score=39.00 ** 273 ICALAIYFLM EVPVFALLYC VVVVVISVVI PFFFV L: 4(11.4%); V: 10(28.6%); I: 4(11.4%); F: 5(14.3%); ____________________________________ High scoring transmembrane segments: 5.00 (LVIF) 2.00 (AGM) 0.00 (BZX) -1.00 (YCW) -2.00 (ST) -6.00 (P) -8.00 (H) -10.00 (NQ) -16.00 (KR) -17.00 (ED) Expected score/letter: -1.898 M_0.01= 96.96; M_0.05= 77.31; M_0.30= 53.93 1) From 267 to 307: length= 41, score=104.00 ** 267 VVLTFTICAL AIYFLMEVPV FALLYCVVVV VISVVIPFFF V L: 5(12.2%); V: 12(29.3%); F: 6(14.6%); 2. SPACINGS OF C. H2N-3-C-107-C-16-C-25-C-50-C-40-C-26-C-17-C-50-COOH 2*. SPACINGS OF C and H. (additional deluxe function for ALEX) H2N-3-C-107-C-16-C-19-H-5-C-39-H-10-C-40-C-8-H-3-H-5-H-7-C-17-C-17-H-32-COOH -------------------------------------------------------------------------------- REPETITIVE STRUCTURES. A. SEPARATED, TANDEM, AND PERIODIC REPEATS: amino acid alphabet. Repeat core block length: 4 B. SEPARATED AND TANDEM REPEATS: 11-letter reduced alphabet. (i= LVIF; += KR; -= ED; s= AG; o= ST; n= NQ; a= YW; p= P; h= H; m= M; c= C) Repeat core block length: 8 -------------------------------------------------------------------------------- MULTIPLETS. A. AMINO ACID ALPHABET. 1. Total number of amino acid multiplets: 21 (Expected range: 7-- 34) 2. Histogram of spacings between consecutive amino acid multiplets: (1-5) 8 (6-10) 3 (11-20) 5 (>=21) 6 3. Clusters of amino acid multiplets (cmin = 11/30 or 14/45 or 17/60): none 4. Long amino acid multiplets (>= 5; Letter/Length/Position): V/5/293 B. CHARGE ALPHABET. 1. Total number of charge multiplets: 5 (Expected range: 0-- 8) 1 +plets (f+: 6.7%), 4 -plets (f-: 6.7%) Total number of charge altplets: 5 (Critical number: 10) 2. Histogram of spacings between consecutive charge multiplets: (1-5) 1 (6-10) 1 (11-20) 1 (>=21) 3 -------------------------------------------------------------------------------- PERIODICITY ANALYSIS. A. AMINO ACID ALPHABET (core: 4; !-core: 5) Location Period Element Copies Core Errors 154- 181 7 L...... 4 4 0 286- 313 7 V...... 4 4 0 293- 297 1 V 5 5 ! 0 B. CHARGE ALPHABET ({+= KR; -= ED; 0}; core: 5; !-core: 5) and HYDROPHOBICITY ALPHABET ({*= KRED; i= LVIF; 0}; core: 6; !-core: 9) Location Period Element Copies Core Errors 22- 84 9 *00.....0 7 7 /0/1/0/./././././2/ 122- 133 2 i0 6 6 /0/2/ 243- 282 5 i...0 8 8 /0/./././2/ 276- 307 2 i. 14 7 2 289- 320 4 i... 8 8 0 293- 309 1 i 14 6 3 -------------------------------------------------------------------------------- SPACING ANALYSIS. There are no unusual spacings. ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ Start with Pfam (from /data/patterns/pfam) hmmpfam - search a single seq against HMM database HMMER 2.1.1 (Dec 1998) Copyright (C) 1992-1998 Washington University School of Medicine HMMER is freely distributed under the GNU General Public License (GPL). - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /data/patterns/pfam/Pfam Sequence file: TRYP10.0.001875_6.fa - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: TRYP10.0.001875_6 Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- DUF6 Integral membrane protein DUF6 -38.1 63 1 Papilloma_E5 Papillomavirus E5 -45.7 56 1 DUF202 Domain of unknown function DUF -52.9 83 1 Na_Ca_Ex Sodium/calcium exchanger protein -63.5 51 1 oxidored_q5_N NADH-ubiquinone oxidoreductase chain 4, -65.2 29 1 SBF Sodium Bile acid symporter family -88.5 44 1 UbiA UbiA prenyltransferase family -95.0 12 1 DsbD Cytochrome C biogenesis protein transme -113.0 59 1 DUF46 Putative integral membrane protein DUF4 -126.5 20 1 DUF205 Domain of unknown function DUF -131.8 89 1 ABC2_membrane ABC-2 type transporter -147.9 43 1 Bac_rhodopsin Bacteriorhodopsin -153.3 61 1 DUF63 Membrane protein of unknown function DU -158.8 32 1 MBOAT MBOAT family -162.2 84 1 ABC-3 ABC 3 transport family -198.2 12 1 Cyto_ox_2 Cytochrome oxidase subunit II -266.8 99 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- DsbD 1/1 70 249 .. 1 226 [] -113.0 59 oxidored_q5_N 1/1 159 249 .. 1 110 [] -65.2 29 SBF 1/1 93 284 .. 1 208 [] -88.5 44 MBOAT 1/1 104 294 .. 1 334 [] -162.2 84 ABC-3 1/1 65 298 .. 1 267 [] -198.2 12 DUF63 1/1 58 304 .. 1 275 [] -158.8 32 DUF6 1/1 164 305 .. 1 126 [] -38.1 63 Na_Ca_Ex 1/1 193 306 .. 1 152 [] -63.5 51 DUF202 1/1 201 309 .. 1 133 [] -52.9 83 Cyto_ox_2 1/1 91 310 .. 1 363 [] -266.8 99 Papilloma_E5 1/1 240 316 .. 1 74 [] -45.7 56 ABC2_membrane 1/1 72 317 .. 1 261 [] -147.9 43 DUF205 1/1 150 319 .. 1 233 [] -131.8 89 DUF46 1/1 192 321 .. 1 192 [] -126.5 20 Bac_rhodopsin 1/1 111 326 .. 1 250 [] -153.3 61 UbiA 1/1 91 341 .. 1 290 [] -95.0 12 Alignments of top-scoring domains: DsbD: domain 1 of 1, from 70 to 249: score -113.0, E = 59 *->aFLAGLLSflSPCvLPliPaylSyisgvslgDvkqgKGvvKPakkvq ++++ K TRYP10.0.0 70 -------------------VNVATYEYN--------K---------- 79 wrvllsallFvlGft.ivFlllGvgaafltallrdyllylrviagvlvIl v l+++ + f+ +vF+l+ +++ + + + l +++ + +l+ + TRYP10.0.0 80 --VVLDTFVVIQQFSfVVFYLFVFSMMLSGRVDECALMWVNATLFTLAFV 127 mGLhflgvfrgliafLrklrlvWelktkkkveisvlgafllGl......l + +++ r ++ ++ +++ + ++l+Gl +++ +l TRYP10.0.0 128 FCIVVQ---R-----QQAVDRG------EIPTP--FTHYLMGLcrqgipL 161 FAlgWtPCigPiLasvlalasstgslvllgalllvvYvLGLg........ ++ + + ++P+L l++a s+++ v l++l ++v vL L++ + + TRYP10.0.0 162 VGVLIL--LSPVLQT-LTVAYSNDTIVTLSSLSMFVHVL-LTdynylncy 207 .......iPfvlaalfagsllsflrwLrkhsraikiasGvLLiliGalll +++ ++++++ +a++++ ++ s+ ++ + sG+L++ +G+l + TRYP10.0.0 208 seryqqnTAVNAATFGIILIASRIQRVFQ--------SGALIM-FGILCF 248 l<-* + TRYP10.0.0 249 T 249 oxidored_q5_N: domain 1 of 1, from 159 to 249: score -65.2, E = 29 *->MLKiIlPTiMLlPtTwlskknwlWintttySlLIsliSLtlLnnhse +P+++ +++ls+ + +++ ++ ++ l SL+++ + TRYP10.0.0 159 -----IPLVG--VLILLSPVLQTLTVAYSNDTIVTLSSLSMFVHVLL 198 ngwnnlsly.......lssDplStPLLvLScWLLPLMlmASQnHLskePl + +n+l+ y+++ ++++++ + + + l+AS TRYP10.0.0 199 TDYNYLNCYseryqqnTAVNAATFGII----------LIASRI------- 231 nrqRlfIslLiiLQtlLImt<-* qR+f s +i +L++t TRYP10.0.0 232 --QRVFQSGALIMFGILCFT 249 SBF: domain 1 of 1, from 93 to 284: score -88.5, E = 44 *->allLflmMfsmglkvefedlkellrrvkPKalilgLllqyiImPllm +++ l fsm+l+ ++++ + + +L+ l+ TRYP10.0.0 93 FVVFYLFVFSMMLSGRVDECALMWVN-------ATLF-------TLA 125 Filawlllrlppedep.......glavGliLvGcaPggamSnvwtylakG F++ +++ r +d ++ +++ + ++ Gl c g+ ++ v +l+ TRYP10.0.0 126 FVFCIVVQRQQAVDRGeiptpftHYLMGL----CRQGIPLVGVLILLSPV 171 dveLsv.....vmvalSTLlsillaplvtPLllfllagllvhvdtvegtl ++L+v +++++v+lS+ ls + +l t + ++ ++ + ++ t +++ TRYP10.0.0 172 LQTLTVaysndTIVTLSS-LSMFVHVLLTDYNYLNCYSERYQQNTAVNAA 220 a..avsplsliksvLvyViiPliaGmltryflpkkKGrewfeqkvlpvls + ++++++s i v++ + + G+l+ +p +++l+ TRYP10.0.0 221 TfgIILIASRIQRVFQSGAL-IMFGILCFTLSP----------IPRHNLK 259 pisligllltivvifalngeviasl<-* +sl + + + i al ++ +++ TRYP10.0.0 260 HVSLRAHVVLTFTICALAIYFLMEV 284 MBOAT: domain 1 of 1, from 104 to 294: score -162.2, E = 84 *->itDGmkkdekeLsseQKrtAlreiPSlLEflaYmfffqgSllLvGPq + +G++++ Al + L la++f+ TRYP10.0.0 104 MLSGRVDEC----------ALMWVNATLFTLAFVFCIV--------- 131 ftysdYiaflngkllrsladskGkpmsskrEvvktPsptklaalrrfvaa ++ + d+ G + P p + +++ + ++ TRYP10.0.0 132 --------VQRQQAV----DR-GEI----------PTPFTHYLMGLCRQG 158 lfylalflllssyf.PldylltdavfpersFfkRllYvlitfmAafvfRy + + + +lls+ +++l+ + +++ + ++s +++++ vl+t TRYP10.0.0 159 IPLVGVLILLSPVLqTLTVAYSNDTIVTLSSLSMFVHVLLTD-------- 200 KYYfaWlisEgiCIlsGlGaYnGayDpkegkgkWdryafdkrekdeleyd Yn + TRYP10.0.0 201 --------------------YNY-LN------------------------ 205 yetirNidilkvEfaqnfregmesWNinTntWLrryVYeRvpkkgkklGF + + ++ + N +n+ ++ +++++ + TRYP10.0.0 206 ---CY---------SERYQQ-----NTAVNA--ATFGIILIASRIQRV-- 234 lStlaTllvSAvWHGlhpGYYltFltealcvtaekqirRlvrprflksgm ++ +a ++ + lc t++ + r +++++ l+ ++ TRYP10.0.0 235 FQSGA-----------------LIMFGILCFTLSPIPRHNLKHVSLRAHV 267 krptisklfydifgwlitkvalgYlitaFvLlslkpsl<-* +++i +a+ +l++ v+ l+ + TRYP10.0.0 268 VL-----------TFTICALAIYFLMEVPVFALLYCVV 294 ABC-3: domain 1 of 1, from 65 to 298: score -198.2, E = 12 *->qyefmqrAllasilvglacgiLGsFlVLRRqSLmGDAiSHavLpGVA ++ q++ +a+ + +L +F+V++ S+ + TRYP10.0.0 65 --DLRQNVNVATYEYNKV--VLDTFVVIQQFSFVV------------ 95 LAffLginkSleipliGAflfgliaAvaigylkrnsrlkeDtaiGIvfss f+L ++++ l+g + a+ ++ ++ +f+ TRYP10.0.0 96 --FYL--------FVFSMMLSGRVDECALMWVNAT-----------LFTL 124 flAlGlll.....islikgsnaaskvdLdhyLFGni........Lgisqq + + +++++++ ++ + + hyL G +++ + ++ i + TRYP10.0.0 125 AFVFCIVVqrqqaVDRGE-----IPTPFTHYLMGLCrqgiplvgVLILLS 169 Dliqiaii.....taiiLlllllfwkeLl.....litFDpdlAkviGlpv ++q++ + +++t+++L+ l+ f + Ll++ + l + ++ + + + ++ TRYP10.0.0 170 PVLQTLTVaysndTIVTLSSLSMFVHVLLtdynyLNCYSERYQQNTAVNA 219 nflkllLliLlaltiVvalqaV...GvILViAlLitPAatArllt....k ++ ++L i+ +q V ++G+++++ ++ + l++ ++ TRYP10.0.0 220 ATFGIIL-------IASRIQRVfqsGALIMF------GILCFTLSpiprH 256 slesmlliAsaiGvvssvaGlllSYyfdtatGpvIVLiatllFlisflfa +l+++ l A ++ +++ a l + + ++++ +++ll+ +++ ++ TRYP10.0.0 257 NLKHVSLRAHVVLTFTICA-LAIYFLMEVP-------VFALLYCVVVVVI 298 <-* TRYP10.0.0 - - DUF63: domain 1 of 1, from 58 to 304: score -158.8, E = 32 *->mLkeFieeYyinpiyykeGYNpVNTvtYAiI..LgiAvillYkkllK + +F + n + YN V t+ +I+++ + v +l+ TRYP10.0.0 58 DPQQFLQDLRQNVNVATYEYNKVVLDTFVVIqqFSFVVFYLF-VFSM 103 kLkIKiDekfflAl......iPyiiLGSlvR.ALvDaGvlprPisyltvT L +De ++ ++ + ++ +++ + R+ vD G +p P ++ ++ TRYP10.0.0 104 MLSGRVDECALMWVnatlftLAFVFCIVVQRqQAVDRGEIPTPFTHYLMG 153 ...PGIYfLvflttIAtLillvklkffkeKyYrklavagGlvLavvalil + GI Lv+ Lill + + + Y ++++++ L ++ +l TRYP10.0.0 154 lcrQGIP-LVGV-----LILLSPVLQTLTVAYSNDTIVTLSSLSMFVHVL 197 lqhilkvvfileVlllfvvfsaiAlvafvlltlkLk.ilrkklnlyvvya l + ++ + +A + + l + + + +++ +++++ TRYP10.0.0 198 LTDYNYLNC-YSERYQQNTAVNAATFGIILIASRIQrVFQS--GALIMFG 244 HlfDassTfvGIdfyGYwEqHvvPryLiglfGTayamyplKflVlltaLY l s ++Pr a +l f + +a Y TRYP10.0.0 245 ILCFTLS--------------PIPRHNLKHVS-LRAHVVLTFTICALAIY 279 iLdklvEdeeereylDFiKLvifiLGLAPGlRDllrmvmgv<-* L + +l + v+++ ++ v TRYP10.0.0 280 FLMEV----PVFALL---YCVVVV---------VISVVIPF 304 DUF6: domain 1 of 1, from 164 to 305: score -38.1, E = 63 *->fiWalytvfskklle.spltftawrfliagilllilllflkkgppl. ++ l+ v++ ++++ s t++++ +l + ++ l++ +l+ TRYP10.0.0 164 VLILLSPVLQTLTVAySNDTIVTLSSLSMF----VHVLLTDYN-YLn 205 .................lallslk.ilallylgilgtalgyllyfya.lk +++ ++++ + + ++l ++i +++ +g+l +++g l+++ +++ TRYP10.0.0 206 cyseryqqntavnaatfGIILIASrIQRVFQSGAL-IMFGILCFTLSpIP 254 yvsaskasvlsslsPvftlils.vllLgEkltlkqllGivlillGvllis + + +s+ +++ ft+++ +++L E + + l +v+++++v++ + TRYP10.0.0 255 RHNLKHVSLRAHVVLTFTICALaIYFLMEVPVFALLYCVVVVVISVVIPF 304 l<-* + TRYP10.0.0 305 F 305 Na_Ca_Ex: domain 1 of 1, from 193 to 306: score -63.5, E = 51 *->ilivlgadlfVdgasaiaevlgisesviGlTlvAlGTSlPElfaSli + vl +d + + e+ + + +v ++T+ + li TRYP10.0.0 193 FVHVLLTDY--NYLNCYSERYQQNTAVNAATFGII----------LI 227 aalkgqfqadiAiGnviGSNifNillglGiasliaplyhkakgesfiVdp a+++ v+ S ++ ++++l +++++p+ + ++ + TRYP10.0.0 228 ASRIQ---------RVFQSGALIMFGIL--CFTLSPIPRH------NLKH 260 islrrdvlflllvllilivflllgrsligrgdgvlllilyilyltflvfs +slr +v++++ +++i+fl+ + ++ +ly+++++++ ++ TRYP10.0.0 261 VSLRAHVVLTFTICALAIYFLM---------EVPVFALLYCVVVVVISVV 301 illev<-* i + TRYP10.0.0 302 IPFFF 306 DUF202: domain 1 of 1, from 201 to 309: score -52.9, E = 83 *->MdnlklgeePDNLAkElvdyRfrlAaERTF....LA..WIRT..ALg ++l + e + +++ + TF+ A++ +R ++ + TRYP10.0.0 201 YNYLNCYSERY--------QQNTAVNAATFgiilIAsrIQRVfqSGA 239 llafGVgldqlvp....elvqlDRiLiPgtRvgeeLslvLglfiIgigvl l+ fG+ l p +++ l + + R + +L +++++++I + TRYP10.0.0 240 LIMFGILCFTLSPiprhNLK------HVSLRAHVVLTFTICALAIYFLM- 282 gLLrwaaNeramrkhidrgryrYtsvllislvllVvlVvvltLafyal<- + + + ll+ +v++V+ Vv + f +l TRYP10.0.0 283 ----------------EVPVFA----LLYCVVVVVISVVI-PFFFVKL 309 * TRYP10.0.0 - - Cyto_ox_2: domain 1 of 1, from 91 to 310: score -266.8, E = 99 *->elLplvWfvligvllfgYvvlDGFDlGVGmllpflakdeeERRillN f +++ lf+++ m+l+ ++ + E + TRYP10.0.0 91 -------FSFVVFYLFVFS----------MMLS--GRVD-ECALM-- 115 sIGPVWDGNEVWLvlaGGALFAAFPlaYAtllSglYlPlilvLvgLiF.R + Atl+ ++++++ +++R TRYP10.0.0 116 -------------------------WVNATLFT------LAFVFCIVVqR 134 GVaFEyRgKiedakWkkvWDwaffiGSlvpalllGv..afGnllqGlPFl a + Rg i+++ ++ + + ++l+ Gv ++ +lq l+++ TRYP10.0.0 135 QQAVD-RGEIPTP----FTHYLMGLCRQGIPLV-GVliLLSPVLQTLTVA 178 vdadlrtsYaGsswdlLnRPfaLLcGlvlvslyalhGatflalKTeGeLq +d t ++ ss + + +LL+ + y + TRYP10.0.0 179 YSND--TIVTLSSLSMFV--HVLLTDYNYLNCY----------------S 208 erarklArylafvtLvavllvglwllyGiDGyvlvsiDtpatsaplakrV er+++ +++ a +t++++l+++ + TRYP10.0.0 209 ERYQQNTAVNA-ATFGIILIASRI------------------------Q- 232 aveigaWwfnfprmpillalpvLgvvafll.......llvalrrgrygwa r++ al+ g+++f l++ ++++l+ + r +++ TRYP10.0.0 233 ------------RVFQSGALIMFGILCFTLspiprhnLKHVSLRAHVVLT 270 F.iltlllialailgagislfPnvmPSsldpaysLTiwnAassplTLkiM F+i++l+ +l + ++++l+ v++ TRYP10.0.0 271 FtICALAIYFLMEVPVFALLYCVVVV------------------------ 296 LvialiflPivLgYtiwsYwVFRGKis<-* ++ +++P+ F+ K+ TRYP10.0.0 297 --VISVVIPF-----------FFVKLH 310 Papilloma_E5: domain 1 of 1, from 240 to 316: score -45.7, E = 56 *->illvFlLCFcV.......lLclClllRPLlLSvsvYAaLLlLVLClL ++ +LCF +++ ++++l ++l +L ++A+++ + l TRYP10.0.0 240 LIMFGILCFTLspiprhnLKHVSLRA-HVVLTFTICALAIY--F-LM 282 WVfvtSpLraFivYliFlYLPlflIHlHAqyLlq<-* V v L + +v +i + +P f lH + q TRYP10.0.0 283 EVPVFALLYCVVVVVISVVIPFFFVKLHGSMKDQ 316 ABC2_membrane: domain 1 of 1, from 72 to 317: score -147.9, E = 43 *->lrslfryreLilqLlkrdiKtRYrgSaLGylWsfLnPLlmilvytfv + + +++ ++ ++++ ++ + ++++y+fv TRYP10.0.0 72 VATYEYNKVVLDTFVV------------------IQQFSFVVFYLFV 100 FsfllrsrlpgddrlnyivylltGllpwqfFsealsrgtssvvanasLik Fs++l r+ ++ +++ + l++ F+ ++ vv++++ + TRYP10.0.0 101 FSMMLSGRV----DECALMWVNATLFT-LAFVFCI------VVQRQQAVD 139 KlnfP.reilplsavlselvvnflisliillivl....ilfgenp.fswn +P+++++ l +++++ + ++ +li+l +vl++ +++++++ +++ TRYP10.0.0 140 RGEIPtPFTHYLMGLCRQG-IPLVGVLILLSPVLqtltVAYSNDTiVTLS 188 vlllpllllll.................vlfslGlglilsalgvffRDig +l++ ++++ll++ + + +++ +++++ ++ +g+il ++ +++ + TRYP10.0.0 189 SLSM-FVHVLLtdynylncyseryqqntAVNAATFGIIL--IASRIQRVF 235 qilglllqll..fflsPifYplstiP.eqyrsillelNPlvhiiesyRdi q l+++ + f lsPi p +++ + ++r+ ++ l+ i +i TRYP10.0.0 236 QSGALIMFGIlcFTLSPI--PRHNLKhVSLRAHVV----LTFTICAL-AI 278 llgGawvpsdlesllylllvslillliGlliFrkf..ekrfa<-* ++ + vp + lly+++v +i i +++++ ++++k+ + TRYP10.0.0 279 YFLME-VP--VFALLYCVVVVVISVVIPFFFVKLHgsMKDQI 317 DUF205: domain 1 of 1, from 150 to 319: score -131.8, E = 89 *->lllAYLlGSIpfGy.lvgKLllgvDiRkvGSgNpGATNVlRaLqskG YL+G G++lvg L+l+ Vl +L TRYP10.0.0 150 ----YLMGLCRQGIpLVGVLILLSP-------------VLQTL---- 175 vsnGkkaAllVlifDilKGmlAvllarliFglgLQqYLtvkvYQdswpL. + + + +l l + ++l L Y + Y + ++ TRYP10.0.0 176 ---TVAYSNDTIV------TLSSLSMFV-HVL-LTDYNYLNCYSERYQQn 214 gmvAWqnWLtLGvclaAvLGHifPvFfkFkGGKgVATslGvllalspw.. ++v A ++G +l s +++ TRYP10.0.0 215 TAVN-------------------------------AATFGIILIASRIqr 233 lalimlavWLlviLlt.........kYVSLaS..ivtaiaaavliLfvwl ++ +++++ ++++ +t ++ ++++ k VSL ++ ++t+ + a++i f+ TRYP10.0.0 234 VFQSGALIMFGILCFTlspiprhnlKHVSLRAhvVLTFTICALAIYFLME 283 pylyffksdPlkaIvyqlkevitlffvlLigPLTilv...iyrHReNIkR + f + ++v++i+ ++++ +++ ++ k TRYP10.0.0 284 V--PVF-------------ALLYCVVVVVIS---VVIpffFVKLHGSMKD 315 LlnG<-* +nG TRYP10.0.0 316 QING 319 DUF46: domain 1 of 1, from 192 to 321: score -126.5, E = 20 *->flrGvqvntDiiniillLkaiWyiLPAY.......vANaSavvfGGG + +L + + L +Y+++ ++++A + a TRYP10.0.0 192 MFV------------HVLLTDYNYLNCYseryqqnTAVNAA------ 220 TPiDfGKtfvDGRRllGDGkTWRGfvgGvlvGtlvGiiQylLlklsiFla +G++ ++ iQ + TRYP10.0.0 221 -------------------------TFGII--LIASRIQRVFQ------- 236 leyyGslliaviLaFLLsfGAlvGDlvGSFIKRRLnieRGk......PAp +G l+ + iL F Ls i+R ++ + +A TRYP10.0.0 237 ---SGALIMFGILCFTLS-----------------PIPRHNlkhvslRAH 266 iLDQLdFligALlfaSLYPPFvkliPieiIilillITpllHlgaNIIAYk ++ L F i AL++ L v ++ + + +++I +++ + k TRYP10.0.0 267 VV--LTFTICALAIYFLME--VPVFALLYCVVVVVISVVI----PFFFVK 308 L..GlKd...VpW<-* L++ +Kd+ + pW TRYP10.0.0 309 LhgSMKDqinGPW 321 Bac_rhodopsin: domain 1 of 1, from 111 to 326: score -153.3, E = 61 *->lttwlwiGaagmllGtllfi.......ymGrgledpearkiyvali. + + w++a ++ l+ ++ i ++++ ++ rg + + ++ l + TRYP10.0.0 111 ECALMWVNATLFTLAFVFCIvvqrqqaVD-RGEIPTPFTHYLMGLCr 156 .lIPgiAivaYlgMalG.iGvttvempaehlaLAGeeVd...tiywaRYl ++IP++ + l+ +l +++v ++++ V ++ ++ + TRYP10.0.0 157 qGIPLVGVLILLSPVLQtLTVAYSNDT---------IVTlssLSMFVH-- 195 DWllTTPLlllfLGLL.AgadrrtiftlvvaDalMIvtGlaAALttGsGv ll + +L+ + r t+v a ++ I L++ TRYP10.0.0 196 -------VLLTDYNYLnCYSERYQQNTAVNAATFGII------LIA---- 228 LsagllRwvlfgiStafflvlLYyLlvnlpraAkdaspgtaslFntLrnl + ++R f ++ + ++L + l+++pr + Lr++ TRYP10.0.0 229 --SRIQR--VFQSGALIMFGILCFTLSPIPRHNLKH--------VSLRAH 266 tvVLWlaYPvvWLlGpeGiGlltvgietllyvvLDvvAKVgFgfilLrsr +v+ ++ + l+ v + +lly v vv V+ f+++ + TRYP10.0.0 267 VVLTFTI------CALAIYFLMEVPVFALLYCVVVVVISVVIPFFFVKLH 310 avlertvavgsalaage<-* + g+ +a TRYP10.0.0 311 GSMKDQIN-GPWDEAKP 326 UbiA: domain 1 of 1, from 91 to 341: score -95.0, E = 12 *->tllvlapvlaglalaaggvn.tgladllllllallgfflaraagnvi +++v++++++ +++ +g v++ l ++ l++l+ +f++ TRYP10.0.0 91 FSFVVFYLFVFSMMLSGRVDeCALMWVNATLFTLAFVFCI------- 130 NDyfDrdiDaineRrisTpnRPlpsGrispkealtfalll..lalglala ++ ++ ++ +G i+ ++ +l+++++ ++++ TRYP10.0.0 131 ----------VVQ-----RQQAVDRGEIPTPFTHYLMGLCrqGIPLVGVL 165 lllnnla..........fllallglalavlYslpYtrllKRytplg.... ll + +++ + +++ +++l +l ++v +l+ y +l+ ++ TRYP10.0.0 166 ILLSPVLqtltvaysndTIVTLSSLSMFVH-VLL-----TDYNYLNcyse 209 ....tvvlgaagalpplmGwvAvtgqltpslsvvailLfaalflwtaphd + +++ ++ aa++ +l++ ++ + a+++f++l++ +p+ TRYP10.0.0 210 ryqqNTAVNAATFGIILIASRIQR-----VFQSGALIMFGILCFTLSPI- 253 iayaleDvedDrkaGvkslpvrlGvekakkiallllavavalllllgllg +l+ + +++ ++l+ al++++++ TRYP10.0.0 254 PRHNLK-------------------HVSLRAHVVLTFTICALAIYFLMEV 284 glgllgilylivvlllgaallvlaiklvrremdpekiekarlllTfvasl + + +ly++vv++ ++ + ++ +kl + m++ ++++++ TRYP10.0.0 285 P--VFALLYCVVVVVISVVIPFFFVKLHGS-MKDQINGPWD----EAKPT 327 illlvlfaalllaf<-* + + ++ a +++ TRYP10.0.0 328 NSAAAVEWANAGML 341 // Start with PfamFrag (from /data/patterns/pfam) hmmpfam - search a single seq against HMM database HMMER 2.1.1 (Dec 1998) Copyright (C) 1992-1998 Washington University School of Medicine HMMER is freely distributed under the GNU General Public License (GPL). - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /data/patterns/pfam/PfamFrag Sequence file: TRYP10.0.001875_6.fa - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: TRYP10.0.001875_6 Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- DUF230 Poxvirus proteins of unknown function 0.4 93 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- DUF230 1/1 267 282 .. 125 140 .] 0.4 93 Alignments of top-scoring domains: DUF230: domain 1 of 1, from 267 to 282: score 0.4, E = 93 *->kflplflialiflill<-* ++l+++++al++++l TRYP10.0.0 267 VVLTFTICALAIYFLM 282 // Start with Repeat Library (from /data/patterns/repeats-Miguel-Andrade/hmm) hmmpfam - search a single seq against HMM database HMMER 2.1.1 (Dec 1998) Copyright (C) 1992-1998 Washington University School of Medicine HMMER is freely distributed under the GNU General Public License (GPL). - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /data/patterns/repeats-Miguel-Andrade/hmm/repeats.hmm-lib Sequence file: TRYP10.0.001875_6.fa - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: TRYP10.0.001875_6 Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- [no hits above thresholds] Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- [no hits above thresholds] Alignments of top-scoring domains: [no hits above thresholds] // ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ Start with Prosite --------------------------------------------------------- | ppsearch (c) 1994 EMBL Data Library | | based on MacPattern (c) 1990-1994 R. Fuchs | --------------------------------------------------------- PROSITE pattern search started: Thu Feb 28 17:35:51 2002 Sequence file: TRYP10.0.001875_6.fa ---------------------------------------- Sequence TRYP10.0.001875_6 (342 residues): Matching pattern PS00001 ASN_GLYCOSYLATION: 118: NATL 181: NDTI Total matches: 2 Matching pattern PS00005 PKC_PHOSPHO_SITE: 8: SLR 34: TVR 106: SGR 208: SER 262: SLR 312: SMK Total matches: 6 Matching pattern PS00006 CK2_PHOSPHO_SITE: 8: SLRE 34: TVRD 312: SMKD Total matches: 3 Matching pattern PS00008 MYRISTYL: 23: GTIGSV 26: GSVSTE Total matches: 2 Matching pattern PS00029 LEUCINE_ZIPPER: 154: LCRQGIPLVGVLILLSPVLQTL Total matches: 1 Total no of hits in this sequence: 14 ======================================== 1314 pattern(s) searched in 1 sequence(s), 342 residues. Total no of hits in all sequences: 14. Search time: 00:00 min ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ Start with Profile Search ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ Start with motif search against own library ***** bioMotif : Version V41a DB, 1999 Nov 11 ***** SeqTyp=2 : PROTEIN search; >APC D-Box is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >ER-GOLGI-traffic signal is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >INTRA-SIGNAL-M minimal SH3 binding is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >INTRA-SIGNAL-M deubiquitinating enzyme SH3 domain binding motif (Kato, 2000) is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >INTRA-SIGNAL-M minimal class I consensus-SH3 binding motif is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >INTRA-SIGNAL-M minimal class II consensus-SH3 binding motif is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >INTRA-SIGNAL-M exact 14-3-3 binding consensus (Muslin 1996 Cell 84 889) is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >INTRA-SIGNAL-M 14-3-3 binding motif in RAF and others (Muslin 1996 Cell 84 889) is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >INTRA-SIGNAL-M WW domain binding motif in formins (Bedford 1997) is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >INTRA-SIGNAL-M PY motif for WW domain is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >TM-CYTOPLASMIC-M di-hydrophobic endocytosis motifs for internalized transmembrane proteins is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >TM-CYTOPLASMIC-M tyrosine-based endocytosis motif for internalized transmembrane proteins is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >TM-EXTRACELL-M Endocytosis signal for internalized transmembrane proteins is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >EXTRACELL-M minimal furin protease cleavage site motif is the MOTIF name >TRYP10.0.001875_6 ;LENGTH=342; DIRECT_SEQUENCE n 2 solutions m %_RXXR 40-43 f m %_RXXR 230-233 f >STATISTICS Total : 2 solutions in 1 sequences, 342 units; out of 1 sequences, 342 units >EXTRACELL-M extended furin protease cleavage site motif is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >EXTRACELL-M zinc binding motif in MMPs is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >EXTRACELL-M g alpha binding go loco is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS PDX-1 experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS QKI-5 experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS HCDA experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS SV40 LrgT experimentally determined is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS H2B experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS v-Rel experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS Amida experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS Amida experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS RanBP3 experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS Pho4p experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS DNAhelicaseQ1 experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS LEF-1 experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS TCF-1 experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR p53-NLS1 NLS experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS hum-Ku70 experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS GAL4 experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS act/inh betaA experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS BDV-P experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS BDV-P experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS BDV-P experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS TR2 experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS THOV NP experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS polyomaVP1 experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS HIV-1 Tat experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS HIV-1 Rev experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS Rex experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS SRY experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS SRY experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS SOX9 experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS SOX9 experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS NS5A experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS DNAse EBV experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS DNAse EBV experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS adenovE1a experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS ystDNApolalpha experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS hVDR experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS CPV capsid experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS hGlu.cort.experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS cFOS experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS cJUN experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS hDNApolalpha experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS hDNAtopoII experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS hDNAtopoII experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS hBLM experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS hARNT experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS influenzaNP experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS influenzaNP experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS p54 experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS hProTalpha experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS Tst1/Oct6 experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS protHsc9 experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS protHsci experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS protHsc3 experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS Ta alpha experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS Pax-QNR experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS Hunt.Dis.pro experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS MyoD experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS MyoD experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS opaque2 experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS CTP experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS HCV experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS HCV experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS p110RB1 experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS VirD2-Nterm experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS VirD2-Cterm experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS Nucloplasmin experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS Nucleolin experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS ICP-8 experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS Nab2 experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS M9 experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS lscMyc experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS humKprotein experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS FluA experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS Mat-alpha experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS polyoma Lrg-T experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS polyoma Lrg-T experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS SV40 VP1 experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS SV40 VP2 experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS polyoma VP2 experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS c-myb experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS N-myc experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS p53 experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS c-erb-A experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS yeast SKI3 experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS L29 experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS L29 experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS Max experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS L3 experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >NUCLEAR NLS dyskerin experimentally determined NLS is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >PDZ domain binding motif science 278_2075_pawson is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units >WW domain binding motif science 278_2075_pawson is the MOTIF name >STATISTICS Total : 0 solutions in 0 sequences, 0 units; out of 1 sequences, 342 units ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~ ~~~ Start with HMM-search search against own library hmmpfam - search a single seq against HMM database HMMER 2.1.1 (Dec 1998) Copyright (C) 1992-1998 Washington University School of Medicine HMMER is freely distributed under the GNU General Public License (GPL). - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /data/patterns/own/own-hmm.lib Sequence file: TRYP10.0.001875_6.fa - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: TRYP10.0.001875_6 Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- [no hits above thresholds] Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- [no hits above thresholds] Alignments of top-scoring domains: [no hits above thresholds] // hmmpfam - search a single seq against HMM database HMMER 2.1.1 (Dec 1998) Copyright (C) 1992-1998 Washington University School of Medicine HMMER is freely distributed under the GNU General Public License (GPL). - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /data/patterns/own/own-hmm-f.lib Sequence file: TRYP10.0.001875_6.fa - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: TRYP10.0.001875_6 Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- [no hits above thresholds] Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- [no hits above thresholds] Alignments of top-scoring domains: [no hits above thresholds] // ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ L. Aravind's signalling DB+ PSSM from other authors IMPALA version 1.1 [20-December-1999] Reference: Alejandro A. Schaffer, Yuri I. Wolf, Chris P. Ponting, Eugene V. Koonin, L. Aravind, Stephen F. Altschul (1999), "IMPALA: Matching a Protein Sequence Against a Collection of "PSI-BLAST-Constructed Position-Specific Score Matrices", Bioinformatics 15:1000-1011. Query= TRYP10.0.001875_6 (342 letters) Searching..................................done Results from profile search Score E Sequences producing significant alignments: (bits) Value PDE cyclic NMP phosphodiesterase domain 22 0.81 BROMO Bromodomain (A chromatin associated domain) 22 0.93 ARR Arrestin domain 23 0.95 SNARE Alpha helical domains which are involved in vesicle fu... 20 4.0 CHLMY Adenovirus like protease domain 20 4.5 S1 S1 RNA binding domain 19 7.0 SEC7 Sec7 like GDP exchange factor for ARF like GTPases 19 7.7 >PDE cyclic NMP phosphodiesterase domain Length = 350 Score = 22.4 bits (47), Expect = 0.81 Identities = 12/35 (34%), Positives = 12/35 (34%) Query: 256 HNLKHVSLRAHVVLTFTICALAIYFLMEVPVFALL 290 Sbjct: 67 HNFTHAFDVTQTVYTFLTSFNAAQYLTHLDIFALL 101 >BROMO Bromodomain (A chromatin associated domain) Length = 94 Score = 22.5 bits (48), Expect = 0.93 Identities = 6/24 (25%), Positives = 6/24 (25%), Gaps = 1/24 (4%) Query: 56 YVDPQQFLQDLRQNVNVATYEYNK 79 Sbjct: 57 YLNFDDFEEDFNLIVSNC-LKYNA 79 >ARR Arrestin domain Length = 454 Score = 22.5 bits (48), Expect = 0.95 Identities = 11/71 (15%), Positives = 11/71 (15%), Gaps = 7/71 (9%) Query: 44 KVLYTRQPYEDNYVDPQQFLQDLRQ---NVNVATYEYNKVVLDTFVVIQQFSFVVFYLFV 100 Sbjct: 302 SKVFAVCPLLSNNKDKRGLALDGQLKHEDTNLASSTILDSKTSKESLG----IVVQYRVK 357 Query: 101 FSMMLSGRVDE 111 Sbjct: 358 VRAVLGPLNGE 368 >SNARE Alpha helical domains which are involved in vesicle fusion Length = 254 Score = 20.2 bits (42), Expect = 4.0 Identities = 4/20 (20%), Positives = 4/20 (20%) Query: 288 ALLYCVVVVVISVVIPFFFV 307 Sbjct: 188 ATLSGIVAFILSLLCGALNL 207 >CHLMY Adenovirus like protease domain Length = 157 Score = 20.2 bits (42), Expect = 4.5 Identities = 8/62 (12%), Positives = 8/62 (12%), Gaps = 2/62 (3%) Query: 202 NYLNCYSERYQQNTAVNAATFGIILIASRIQ--RVFQSGALIMFGILCFTLSPIPRHNLK 259 Sbjct: 78 NFLIKESHARKLETPLTLKDFQVQHATNVPRQTNTSDCGVFSCMFAEYITRNISLTFSQK 137 Query: 260 HV 261 Sbjct: 138 DM 139 Score = 19.4 bits (40), Expect = 8.5 Identities = 8/67 (11%), Positives = 8/67 (11%), Gaps = 8/67 (11%) Query: 50 QPYEDNYVDPQQFLQDLRQNVNVATYEYNKVVLDTFVVIQQFS-----FVVFYLFVFSMM 104 Sbjct: 73 LNALRNFLIKESHARKLETPLTLKDF---QVQHATNVPRQTNTSDCGVFSCMFAEYITRN 129 Query: 105 LSGRVDE 111 Sbjct: 130 ISLTFSQ 136 >S1 S1 RNA binding domain Length = 305 Score = 19.5 bits (40), Expect = 7.0 Identities = 5/34 (14%), Positives = 5/34 (14%), Gaps = 2/34 (5%) Query: 293 VVVVVISVVIPFFFVKLHGSMKDQINGPWDEAKP 326 Sbjct: 243 ISVYVQEIDEYKNRISL--STRILETYPGELVEK 274 >SEC7 Sec7 like GDP exchange factor for ARF like GTPases Length = 192 Score = 19.4 bits (40), Expect = 7.7 Identities = 10/46 (21%), Positives = 10/46 (21%), Gaps = 11/46 (23%) Query: 58 DPQQFLQDLRQNVN-----VATY------EYNKVVLDTFVVIQQFS 92 Sbjct: 35 TPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFS 80 Underlying Matrix: BLOSUM62 Number of sequences tested against query: 105 Number of sequences better than 10.0: 7 Number of calls to ALIGN: 8 Length of query: 342 Total length of test sequences: 20182 Effective length of test sequences: 16738.0 Effective search space size: 5174176.1 Initial X dropoff for ALIGN: 25.0 bits Y. Wolf's SCOP PSSM IMPALA version 1.1 [20-December-1999] Reference: Alejandro A. Schaffer, Yuri I. Wolf, Chris P. Ponting, Eugene V. Koonin, L. Aravind, Stephen F. Altschul (1999), "IMPALA: Matching a Protein Sequence Against a Collection of "PSI-BLAST-Constructed Position-Specific Score Matrices", Bioinformatics 15:1000-1011. Query= TRYP10.0.001875_6 (342 letters) Searching.................................................done Results from profile search Score E Sequences producing significant alignments: (bits) Value gi|417452 [24..351] beta-Lactamase/D-ala carboxypeptidase 25 2.0 gi|1060878 [22..383] beta-Lactamase/D-ala carboxypeptidase 24 3.4 gi|2506131 [675..907] The "swivelling" beta/beta/alpha domain 24 3.7 gi|999647 [1..512] Ferritin-like 24 3.9 gi|1127061 [6..559] Single-stranded right-handed beta-helix 24 4.8 gi|285263 [5..313] beta-Lactamase/D-ala carboxypeptidase 23 7.2 >gi|417452 [24..351] beta-Lactamase/D-ala carboxypeptidase Length = 328 Score = 24.9 bits (54), Expect = 2.0 Identities = 11/51 (21%), Positives = 11/51 (21%), Gaps = 6/51 (11%) Query: 120 TLFTLAFV---FCIVVQRQQAVDRGEI--PTPFTHYLMGLCRQGIPLVGVL 165 Sbjct: 32 SLFELASLSKPFTALGI-ILLEEKGILGYEDKVDRWLPGFPYQGVTIRHLL 81 >gi|1060878 [22..383] beta-Lactamase/D-ala carboxypeptidase Length = 362 Score = 24.1 bits (52), Expect = 3.4 Identities = 20/77 (25%), Positives = 20/77 (25%), Gaps = 11/77 (14%) Query: 120 TLFTLAFV---FCIVVQRQQAVDRGEI--PTPFTHYLMGLCRQGIPLVGVLILLS----- 169 Sbjct: 57 TLFELGSISKTFTGVLG-GDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGG 115 Query: 170 PVLQTLTVAYSNDTIVT 186 Sbjct: 116 LPLQVPDEVTDNASLLR 132 >gi|2506131 [675..907] The "swivelling" beta/beta/alpha domain Length = 233 Score = 24.1 bits (52), Expect = 3.7 Identities = 15/58 (25%), Positives = 15/58 (25%), Gaps = 5/58 (8%) Query: 196 VLLTDYNYLNCYSERYQQNTAVNAATFGI-ILIASRIQRVFQSGALIMFGILCFTLSP 252 Sbjct: 107 VVLAGKDY-GMGSSRDWAAKGTNL--LGIRTVIAESFERIHRSN-LVFMGVLPLQFKQ 160 >gi|999647 [1..512] Ferritin-like Length = 512 Score = 24.1 bits (52), Expect = 3.9 Identities = 13/94 (13%), Positives = 13/94 (13%), Gaps = 3/94 (3%) Query: 15 MGEAAQPRGTIGSVSTETAT--VRDEGRVWRKVLYTRQPYEDNYVDPQQFLQDLRQNVNV 72 Sbjct: 105 AATGMLWDSAQAAEQKNGYLAQVLDEIRHTHQCAYVNYYFAKNGQDPAGHNDARRTRTIG 164 Query: 73 ATYE-YNKVVLDTFVVIQQFSFVVFYLFVFSMML 105 Sbjct: 165 PLWKGMKRVFSDGFISGDAVECSLNLQLVGEACF 198 >gi|1127061 [6..559] Single-stranded right-handed beta-helix Length = 554 Score = 23.6 bits (50), Expect = 4.8 Identities = 24/97 (24%), Positives = 24/97 (24%), Gaps = 17/97 (17%) Query: 150 YLMGLCR-QGIPLVGVLILLSPVLQTLTVAYSNDTIVTLSSLSMFVHVLLTDYNYLNCYS 208 Sbjct: 379 YISGACRVNGLRLIGI---RSTDGQSLTIDAPNSTVSGITG--------MVDPSRINVAN 427 Query: 209 ERYQQNTAVNAATFG-----IILIASRIQRVFQSGAL 240 Sbjct: 428 LAEEGLGNIRANSFGYDSAAIKLRIHKLSKTLDSGAL 464 >gi|285263 [5..313] beta-Lactamase/D-ala carboxypeptidase Length = 309 Score = 22.9 bits (49), Expect = 7.2 Identities = 9/54 (16%), Positives = 9/54 (16%), Gaps = 5/54 (9%) Query: 116 WVNATLFTLAFV---FCIVVQRQQAVDRGEI-PTPFTHYLMGLCRQGIPLVGVL 165 Sbjct: 48 MTLDTRMPICSVSKQFTCAVL-LDAVGEPELLDDALEAYLDKFEDERPAVRDLC 100 Underlying Matrix: BLOSUM62 Number of sequences tested against query: 1187 Number of sequences better than 10.0: 6 Number of calls to ALIGN: 6 Length of query: 342 Total length of test sequences: 256703 Effective length of test sequences: 210706.0 Effective search space size: 63856236.1 Initial X dropoff for ALIGN: 25.0 bits ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ calculation of internal repeats with prospero ***** PROSPERO v1.3 Thu Feb 28 17:36:29 2002 ***** Copyright 2000, Richard Mott, Wellcome Trust Centre for Human Genetics, University of Oxford For help see http://www.well.ox.ac.uk/ariadne For usage use -help using gap penalty 11+1k using matrix BLOSUM62 printing all alignments with eval < 0.100000 using sequence1 TRYP10.0.001875_6 using self-comparison ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ ~~~~~ TIGRFAM hmmpfam - search a single seq against HMM database HMMER 2.1.1 (Dec 1998) Copyright (C) 1992-1998 Washington University School of Medicine HMMER is freely distributed under the GNU General Public License (GPL). - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /data/patterns/tigrfam/tigrfam.hmm Sequence file: TRYP10.0.001875_6.fa - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: TRYP10.0.001875_6 Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- TIGR00077 lspA: lipoprotein signal peptidase -88.8 75 1 TIGR00317 cobS: cobalamin 5'-phosphate synthase/cobal -132.0 60 1 TIGR01065 hlyIII: channel protein, hemolysin III fami -145.9 89 1 TIGR00912 2A0309: spore germination protein (amino ac -220.3 34 1 TIGR00850 lacE: pts system, lactose-specific iibc com -298.1 42 1 TIGR00410 pts: phosphotransferase system (pts) -312.7 90 1 TIGR00905 2A0302: arginine/ornithine antiporter -393.1 35 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- TIGR00905 1/1 15 296 .. 1 507 [] -393.1 35 TIGR00912 1/1 17 310 .. 1 359 [] -220.3 34 TIGR00850 1/1 40 311 .. 1 451 [] -298.1 42 TIGR01065 1/1 163 313 .. 1 224 [] -145.9 89 TIGR00077 1/1 171 315 .. 1 183 [] -88.8 75 TIGR00410 1/1 70 320 .. 1 450 [] -312.7 90 TIGR00317 1/1 123 341 .. 1 253 [] -132.0 60 Alignments of top-scoring domains: TIGR00905: domain 1 of 1, from 15 to 296: score -393.1, E = 35 *->MseekdsSkKlGlfALtALVvgSMiGsGIFsLPqnlAsvAgpGAvlI M e+ + ++G s + A v + G v TRYP10.0.0 15 MGEAAQPRGTIG------------------SVSTETATVRDEGRV-- 41 GWiITGvGmlaLAfvFanLatkkPeLdGGiyaYAreGFGpyiGFsSgWGY W +L t+ P d TRYP10.0.0 42 -WR-------------KVLYTRQPYEDN---------------------- 55 WlsawIGNVaYavllfSaLgyFfPtPELRlFgsgnpvpsIlgaSvLlWvv +++ P l +++v v+ TRYP10.0.0 56 ---------------------YVD-PQQFLQDLRQNVN----------VA 73 tflvlrGvrqAAfINtitTiaKliPlflFiIigwfwFkldlFtadfWghd t+ ++ v + +++i f F+++ +f+F+ TRYP10.0.0 74 TYEYNKVVLDT---------FVVIQQFSFVVFYLFVFSM----------- 103 vpsLGSdvfsQVkntMlvTLWvFiGIEGAvvsSgrAknPksDVGkATvlG ++Sgr+ TRYP10.0.0 104 ------------------------------MLSGRVDE------------ 111 llgaLvIYiliTl....LslGvltqqeLA....nlpnPSmAavlehivGk +++ + +Tl + + ++ q + A +++++p P++ TRYP10.0.0 112 ---CALMWVNATLftlaFVFCIVVQRQQAvdrgEIPTPFT---------- 148 WGavLIslGLiiSvLGslLSWtllvAEipflAAkdGlFPkiFgrvNkkga +L++l +g+ TRYP10.0.0 149 --HYLMGL-------------------------------------CRQGI 159 Psva.LllTnilvQlflllilltnsagslssaYntllsLAtvmiLvPYll P v+ L+l + + Q l++ + +++ +tl sL ++ TRYP10.0.0 160 PLVGvLILLSPVLQ--TLTVAYS------NDTIVTLSSLS--------MF 193 SaayLlklskvgnGitHPHAGetypkkGPEiepiknrkalivGviAvvYs + + L + + y + r + ++v A+ ++ TRYP10.0.0 194 VHVLLTDYNYLN----------CYSE----------RYQQNTAVNAATFG 223 vwLlYAAGlkyLLlgfIlyapGiifYgrarkergkdkhvfnkkEiliati ++L+ A+ + ++ + l Gi+ + + r + khv +++ +++ TRYP10.0.0 224 IILI-ASRIQRVFQSGALIMFGILCFTLSPIPRHNLKHVSLRAHVVLTFT 272 ivilAv.....iAiilLvsGsIsI<-* i lA+ ++ ++ L+ + TRYP10.0.0 273 ICALAIyflmeVPVFALLYCVVVV 296 TIGR00912: domain 1 of 1, from 17 to 310: score -220.3, E = 34 *->KltttQ..aliiivntlLGaGvLTLPRAlaeKaktPDgWLavLLgGl + Q+++ i v+t+ + + +W vL + TRYP10.0.0 17 --EAAQprGTIGSVSTETAT--------VRDEG---RVWRKVLYTRQ 50 if...iffillmlkLlkkypgktLfeyqqkilGKwIGnlLnlliigYFLg +++ + +l l ++ +ey++ +l ++ + + +++ L TRYP10.0.0 51 PYednYVDPQQFLQDLRQNVNVATYEYNKVVLDTFV-VIQQFSFVVFYLF 99 vssfviRtma.EvikfFlletTptfvivllfmlVgiYlisgGiesIArSG v s + ++E + + ++ +f + + f+ +++ +++ r G TRYP10.0.0 100 VFSMMLSGRVdECALMWV--NATLFTLAFVFC-----IVVQRQQAVDR-G 141 lfefIfpitliIf...lfllliSfklfdidNLrPVLgeGikpvlksa.kt +++ f+ l ++ ++++ l ++ l L PVL + v+ s ++ TRYP10.0.0 142 EIPTPFTHYLMGLcrqGIPLVGVLIL-----LSPVLQT--LTVAYSNdTI 184 tslsFtGfEiiLftmLlpFmkkpKkakkaallGiliSlilYiiTllivig ++ls + + + + L + ++ ++ + + + + TRYP10.0.0 185 VTLSSLSMFVHVL--LTDYNYLNCYSERYQQ------------NTAVNAA 220 aLsvdevktviWPtiSlvqsievpGiFiERfesfllvvwiiqifatfiis +++ ++ +i ++++ + i+ + +f++ TRYP10.0.0 221 TFGIILIASRI------QRVFQSG-------------ALIMFGILCFTL- 250 fyAaaiglaeiFklkqksnAWlliAliiitfiIsmlpkdlNDvlkygdlL + i + + +++ + l + + + ++ m v ++ l TRYP10.0.0 251 ---SPIPRHNLKHVSLRAHVVLTFTICALAIYFLME------VPVFALLY 291 GyifLfLiyllPfilfiivwlk<-* +++ + ++P f+ v l TRYP10.0.0 292 CVVVVVISVVIP---FFFVKLH 310 TIGR00850: domain 1 of 1, from 40 to 311: score -298.1, E = 42 *->MnkviasLEkklkPfaeKIarnrYLrAIRDGFIlsMPliifGSiFLL +v ++ r++Y TRYP10.0.0 40 --RVWRKV---------LYTRQPYED--------------------- 54 iayv.PnafgeellaftwgkdleaklmeplnqlkGiGGnvyyytmGImaL +yv+P f + + +++ + + +n TRYP10.0.0 55 -NYVdPQQFL-----QDLRQNV-NVATYEYN------------------- 78 fVaFgiAknLaesykvdalsaGqIslaafllatpysvlilaagpakeggv kv + + I +f + + ++ +g e + TRYP10.0.0 79 --------------KVVLDTFVVIQQFSFVVFYLFVFSMMLSGRVDECAL 114 lgasWfPvIparymGtkGLftAiIiAlvsvevYkfiVkrNvvIKLPesVP ++ + Lft +A+v + ++V+r + e TRYP10.0.0 115 M-----------WVNAT-LFT---LAFV----FCIVVQRQQAVDRGE--- 142 PaVsqSFkaLIPgfaviivlwairlaikatlgesfheiImvllsplLsal IP + ++++ r +i ++ + ++++l ++ + TRYP10.0.0 143 ----------IPTPFTHYLMGLCRQGIPLVGVLILLSPVLQTL-TVAYSN 181 DgyvGGilvivgavaLLWFcGiHGasIVepaiapImlsnmdaN.iaalqa D+ v + +++v+ L ++d N + ++ TRYP10.0.0 182 DTIVT-LSSLSMFVHVL---------------------LTDYNyLNCYSE 209 ggsveaaLaaqhlphiltsgflDsfvyiGGsGATLvlplammlaaRSkql +++ ++G ++++a+R ++ TRYP10.0.0 210 R---------------YQQNTAVNAATFG----------IILIASRIQRV 234 KaiGrlavvPgiFniNEPIlFGaPIVlNPvLfIPFiLvPiVnViifkafv + G l I+FG ++ F L Pi + + TRYP10.0.0 235 FQSGAL------------IMFG---------ILCFTLSPIPRHNLKHVSL 263 stGiinksvgvavPWTtPgpigiflsTGfkvlsfVLallllvidvvIYyP + +++ + ++i++ v +++ + +vi+vvI + TRYP10.0.0 264 RAHVVL-TFTICA-------LAIYFLMEVPVFALLYCVVVVVISVVIPFF 305 FvkvyD<-* Fvk TRYP10.0.0 306 FVKLHG 311 TIGR01065: domain 1 of 1, from 163 to 313: score -145.9, E = 89 *->eEiaNaiTHgiGavlsiialalLviyavdhg.avavvgfsiYGiSLi g+ ++ls ++ +l v+y+ d+ +++++ + + TRYP10.0.0 163 ---------GVLILLSPVLQTLTVAYSNDTIvTLSSLSMFVH----V 196 lLFlvSTlYHsipWkgskWPCLWqlrtaknwlrkiDHsmIYVLIAGTYTP lL T Y ++ ++++ +q ta+n A+T TRYP10.0.0 197 LL----TDYNYLNCYSER----YQQNTAVN--------------AAT--- 221 flllanldgplgwtvlviiWglAil..GIilklf..fhkrpfrwLslvlY f +++ +++++ + ++A++ GI+ ++++++++ + +sl TRYP10.0.0 222 FGIIL-----IASRIQRVFQSGALImfGILCFTLspIPRHNLKHVSLRAH 266 LvMGWlvvlvikplyenLpgaglvlLalGGllYtvGaifYalkwkiPPRR +v+ + + +++ + p+ ++lL Y+v +++ + iP TRYP10.0.0 267 VVLTFTICALAIYFLMEVPV--FALL------YCVVVVVISVV--IP--- 303 LGnfntfgyHaIWHlFVlgASacHfvailfyv<-* f+ fv + ++ TRYP10.0.0 304 ---FF-------------------FVKLHGSM 313 TIGR00077: domain 1 of 1, from 171 to 315: score -88.8, E = 75 *->msqslsAnkkglllywlvailligfDqLsKylvlq.nfdlgetyinG ++q+l+ + l+ ++ + ++L+ y l + + ++ TRYP10.0.0 171 VLQTLTVAYSNDTIVTLSSLSMFVHVLLTDYNYLNcYSERYQQ---- 213 adnTivalsgvfnItyvrNtGaAFSlLa..dqgGWqvyflkgLalaIslg nT v + f I+++ S ++ +q+G +I g TRYP10.0.0 214 --NTAV-NAATFGIILIA------SRIQrvFQSG----------ALIMFG 244 lvvFllrykelqkitniaygLIlGGavGNviDRlvrGsdgVVDfldfylg ++ F l+ + + +++ r+ V+ f + l TRYP10.0.0 245 ILCFTLSPIPRHNLKHVSL----------------RA-HVVLTFTICALA 277 nyhGLDRfpiFNlADvsIcvGvilLllkfFfpk.rKkkkd<-* +y+ L p+F l +++v vi ++ fFf k +kd TRYP10.0.0 278 IYF-LMEVPVFALL-YCVVVVVISVVIPFFFVKlHGSMKD 315 TIGR00410: domain 1 of 1, from 70 to 320: score -312.7, E = 90 *->LvPiAgkIgkqRhLqALRDGfiltMPLtIiGSfFllLtNLPfpgseg + ++ + + D F+++ f TRYP10.0.0 70 -----VNVATYEYNKVVLDT-------------FVVIQQFSFVV--- 95 sFFYsLGlladfmavellnsykgklgyp.vnatmgIMSlfavFGIGYrLa + f + +l++ + + vnat+ l vF I TRYP10.0.0 96 --------FYLFVFSMMLSGRVDECALMwVNATL--FTLAFVFCIVVQ-- 133 esYkVdAlsaGalSlaaFLllTpqsDWvPfsvdgateaimvGgWFPvIpa + A+ G + T Pf+ + + G TRYP10.0.0 134 ---RQQAVDRGEIP-------T------PFT-H-----YLMG-------- 153 nlLGakGl.FvaiIiAlvStEiYrfIVQkNlvIKlPdgVPPAVsKSFvAL L +G++ v+++i l+S TRYP10.0.0 154 --LCRQGIpLVGVLI-LLS------------------------------- 169 IPgFiiliVvllinlaveltlgtnlHniImdligTPLsiLGsslggtLvi P+ +l+V+ + +v+ ++ +L TRYP10.0.0 170 -PVLQTLTVAYSNDTIVT--------------LS------------SLSM 192 eFfvmlLWfcGLHGaniigalmnPIwygaldeNiaAyqageelPAALAAG fv+ L l + y l yq++ ++ TRYP10.0.0 193 --FVHVL-------------LTD---YNYLNCYSERYQQNTAVN------ 218 KtFhIlakpFldiftVniGGsGATLaLvltilirsrSkqmKQvgkLalaP AT ++ ili+sr + Q g L TRYP10.0.0 219 ---------------------AATFGI---ILIASRIQRVFQSGAL---- 240 GiFNINEPIiFGlPIVMNPiliiPFvLaPlvtitvTYiamstGlvprPvg I+FG i+ F L P+ + + + v + TRYP10.0.0 241 --------IMFG---------ILCFTLSPIPRHNLKHVSLRAHVVLT-FT 272 iaVPWTmPplisgflaTgGsvsgaVmqLiNLlIsfviYlPFlkawDKakl i + ++ ++ v +++ + +Is+vi + F+k k TRYP10.0.0 273 ICA-------LAIYFLMEVPVFALLYCVVVVVISVVIPFFFVKLHGSMKD 315 aeEkE<-* + TRYP10.0.0 316 QINGP 320 TIGR00317: domain 1 of 1, from 123 to 341: score -132.0, E = 60 *->mlkllrallSFlTrLPlkgewsqGlDfEeiarniwl.........fp l F + + + q +D ei +++ + ++++p TRYP10.0.0 123 -------TLAFVFCIVVQR--QQAVDRGEIPTPFTHylmglcrqgIP 160 LiGiLIGl..ivgipgvilsfvlpnlllAvvlylfiegltGghHlDGLAD L+G LI+l++++ + v+ s + + l+ ++ ++ ++lt TRYP10.0.0 161 LVGVLILLspVLQTLTVAYS-NDTIVTLSSLSMFVHVLLT---------- 199 fGDglfapgskrrkleaMkDsrlGtGGvvalivvfLlkilaLsslalrvl D ++r ++ +v ++ + ++i++ + +rv TRYP10.0.0 200 --DYNYLNCYSER-----YQQNT----AVNAATFGIILIASR--I-QRVF 235 alylllgeVcAklsmlllllvsrPRYlreeGtGryFiekidsrPDLLLdt +++l++ + l+ ++s P r+ + ++r ++L TRYP10.0.0 236 QSGALIM------FGILCFTLS-P-------IPRHNLKHVSLRAHVVLTF 271 vIgvilglplllllagvprilvvaAlavtiligll..lgryakrhFgGvt +I + +++ l vp v+Al+ +++++++ + + ++ G+ TRYP10.0.0 272 TIC----ALAIYFLMEVP----VFALLYCVVVVVIsvVIPFFFVKLHGSM 313 GDVl............GAsnElgevvsLLaL<-* D ++++ ++ +++++ A++E+ ++ L TRYP10.0.0 314 KDQIngpwdeakptnsAAAVEWANAGML--- 341 // hmmpfam - search a single seq against HMM database HMMER 2.1.1 (Dec 1998) Copyright (C) 1992-1998 Washington University School of Medicine HMMER is freely distributed under the GNU General Public License (GPL). - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /data/patterns/tigrfam/tigrfam.hmm-f Sequence file: TRYP10.0.001875_6.fa - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: TRYP10.0.001875_6 Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- TIGR00967 3a0501s007: preprotein translocase SecY sub -1.5 68 1 TIGR00444 mazG: MazG family protein -2.1 88 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- TIGR00967 1/1 269 282 .. 1 17 [. -1.5 68 TIGR00444 1/1 321 325 .. 249 253 .] -2.1 88 Alignments of top-scoring domains: TIGR00967: domain 1 of 1, from 269 to 282: score -1.5, E = 68 *->rerllfTlglLvlfRlG<-* l+fT+++L +++l+ TRYP10.0.0 269 ---LTFTICALAIYFLM 282 TIGR00444: domain 1 of 1, from 321 to 325: score -2.1, E = 88 *->WqevK<-* W+e+K TRYP10.0.0 321 WDEAK 325 // SMART hmmpfam - search a single seq against HMM database HMMER 2.1.1 (Dec 1998) Copyright (C) 1992-1998 Washington University School of Medicine HMMER is freely distributed under the GNU General Public License (GPL). - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /data/patterns/iprscan/data/smart.HMMs Sequence file: TRYP10.0.001875_6.fa - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: TRYP10.0.001875_6 Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- [no hits above thresholds] Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- [no hits above thresholds] Alignments of top-scoring domains: [no hits above thresholds] // COG hmmpfam - search a single seq against HMM database HMMER 2.1.1 (Dec 1998) Copyright (C) 1992-1998 Washington University School of Medicine HMMER is freely distributed under the GNU General Public License (GPL). - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /data/patterns/cogs/cogs.hmm Sequence file: TRYP10.0.001875_6.fa - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: TRYP10.0.001875_6 Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- COG2212 -41.0 38 1 COG1266 -63.1 81 1 COG2891 -82.9 25 1 COG2426 -86.6 98 1 COG3371 -100.6 61 1 COG2245 -101.7 51 1 COG3374 -104.4 61 1 COG0670 -112.8 11 1 COG0697 -115.9 96 1 COG0730 -117.8 30 1 COG0575 -126.6 52 1 COG1183 -127.7 12 1 COG1682 -131.1 40 1 COG2364 -150.7 30 1 COG1279 -151.2 77 1 COG1612 -165.4 87 1 COG1684 -177.7 85 1 COG0472 -184.6 53 1 COG1108 -188.8 90 1 COG0555 -194.7 79 1 COG0395 -199.8 29 1 COG1177 -204.0 70 1 COG0385 -215.9 4.2 1 COG1174 -222.5 70 1 COG1294 -223.5 81 1 COG0341 -226.5 79 1 COG0798 -244.7 47 1 COG0772 -261.8 90 1 COG2311 -271.9 28 1 COG2814 -307.8 89 1 COG1455 -317.7 34 1 COG1914 -332.1 54 1 COG1113 -415.3 18 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- COG2212 1/1 154 240 .. 1 88 [] -41.0 38 COG1279 1/1 99 257 .. 1 230 [] -151.2 77 COG0670 1/1 49 284 .. 1 262 [] -112.8 11 COG2426 1/1 159 284 .. 1 156 [] -86.6 98 COG2891 1/1 137 291 .. 1 173 [] -82.9 25 COG1266 1/1 71 293 .. 1 279 [] -63.1 81 COG3374 1/1 101 296 .. 1 211 [] -104.4 61 COG1684 1/1 82 304 .. 1 272 [] -177.7 85 COG0472 1/1 66 309 .. 1 432 [] -184.6 53 COG1108 1/1 81 311 .. 1 292 [] -188.8 90 COG0575 1/1 112 312 .. 1 345 [] -126.6 52 COG0730 1/1 90 313 .. 1 287 [] -117.8 30 COG1612 1/1 1 314 [. 1 402 [] -165.4 87 COG0555 1/1 98 316 .. 1 269 [] -194.7 79 COG1183 1/1 130 316 .. 1 308 [] -127.7 12 COG0697 1/1 84 316 .. 1 321 [] -115.9 96 COG0772 1/1 43 316 .. 1 416 [] -261.8 90 COG1682 1/1 43 317 .. 1 276 [] -131.1 40 COG1177 1/1 105 317 .. 1 286 [] -204.0 70 COG1294 1/1 81 318 .. 1 390 [] -223.5 81 COG3371 1/1 146 319 .. 1 217 [] -100.6 61 COG2814 1/1 69 320 .. 1 407 [] -307.8 89 COG0385 1/1 80 321 .. 1 395 [] -215.9 4.2 COG0341 1/1 28 322 .. 1 367 [] -226.5 79 COG2245 1/1 152 323 .. 1 197 [] -101.7 51 COG1113 1/1 58 326 .. 1 481 [] -415.3 18 COG0798 1/1 56 329 .. 1 434 [] -244.7 47 COG2364 1/1 95 329 .. 1 242 [] -150.7 30 COG1174 1/1 1 330 [. 1 361 [] -222.5 70 COG1455 1/1 44 332 .. 1 471 [] -317.7 34 COG2311 1/1 64 333 .. 1 448 [] -271.9 28 COG0395 1/1 152 339 .. 1 304 [] -199.8 29 COG1914 1/1 1 342 [] 1 546 [] -332.1 54 Alignments of top-scoring domains: COG2212: domain 1 of 1, from 154 to 240: score -41.0, E = 38 *->MleliinialiligLallLafyRvirGPtlsDRvVALDtlntnlvgi ++i+++++li+L+ L ++ v+ ++++ +V L++l+ + ++ TRYP10.0.0 154 LCRQGIPLVGVLILLSPVLQTLTVAYSNDT---IVTLSSLSMFVHVL 197 lv......LlgilsgrsiylDIALVlaLLsFiGTIA..fAKyLegRGei< l++ + ++++ ++ + ++ +A +L IA+++ ++++ G + TRYP10.0.0 198 LTdynylnCYSERYQQNTAVNAATFGIIL-----IAsrIQRVFQS-GAL 240 -* TRYP10.0.0 - - COG1279: domain 1 of 1, from 99 to 257: score -151.2, E = 77 *->mtiSLmiEKKCERSFfmfs.sflqGflLaagLIlaiGaQNaFVlnQG S+m+ + + +m++++ l f La+ ++ + Q Q TRYP10.0.0 99 FVFSMMLSGRVDECALMWVnATL--FTLAFVFCIVVQRQ------QA 137 irRkkleyvLpivaLCsvcDivLIslGVfGvgAlihenprlllvvtlGGa R g + + l ++ G+ TRYP10.0.0 138 VDR----------------------------GEIPTPFTHYLMGLCRQGI 159 aFLlgYGflAlrtAlrpSnaklapatpkkqslkkVllfaLAVTlLNPHVY ++ +++l+p +l +L+V N TRYP10.0.0 160 ------PLVGVLILLSP------------------VLQTLTVAYSN---- 181 LDTVvlIGalglqfkadeKwlFalGtisASfvWFflLalgAarLgpllan DT+v + +l++ +++ L + r+++ a TRYP10.0.0 182 -DTIVTLSSLSMFVHVLL-------------TDYNYLNCYSERYQQNTAV 217 NpkawrilnllV.........AamMwglAvqLlvdslallskn<-* N++++ i+ +++ ++ +++A++M+g+ L +++ ++ +n TRYP10.0.0 218 NAATFGIILIASriqrvfqsgALIMFGI---LCFTLSPIPRHN 257 COG0670: domain 1 of 1, from 49 to 284: score -112.8, E = 11 *->MglydrmqsrnfektqaeargetliaqvvlkmtygLLltalvasaag ++y + + +++ q++ ++ + + ++k ++ +++ +s+++ TRYP10.0.0 49 RQPYEDNYVDPQQFLQDLRQNVNVATYEYNKVVLDTFVVIQQFSFVV 95 afvalaallpspglfsttflvlilallg.lvfliflmikkrnsaY..... ++ +++++ s ++ +l ++ a+l++l+f++ ++++ + +++ + TRYP10.0.0 96 FYLFVFSMMLSGRV-DECALMWVNATLFtLAFVFCIVVQRQQAVDrgeip 144 ....WYtglalffvytgL.sGytLspilnvylatsGaGgdvIasAFgiTa ++ + Y+ + +++ +++ ++Lsp+l+ + ++ ++ +v +s +++ TRYP10.0.0 145 tpftHYLMGLCRQGIPLVgVLILLSPVLQTLTVAYSNDTIVTLSSLSM-- 192 ivFggmSayGlttrFNkkDlsflgk...fLfmaLigLv.vasLvNlvlGF F+ + ++ ++ + s + +++++++a +g++ +as ++ TRYP10.0.0 193 --FVHVLLTDYNY---LNCYSERYQqntAVNAATFGIIlIASRIQ----- 232 slFlgssalnlaISalGvilFsglIlyDtqnIirggrkligddteisedl +++s al++ +G++ F+ l + + n++++ + TRYP10.0.0 233 -RVFQSGALIM----FGILCFT-LSPIPRHNLKHVS-----------LRA 265 sIraALsLYLdfINLFlsLLrIlgilnddD<-* +++ +++ + ++++ + + TRYP10.0.0 266 HVVLTFT-----------ICALAIYFLMEV 284 COG2426: domain 1 of 1, from 159 to 284: score -86.6, E = 98 *->MkFlEvLlLSLmPtfElRyAiilGlalGlsllEaLllSvlGNvLils + + vL+L L P ++ l +s lS l + TRYP10.0.0 159 IPLVGVLIL-LSP-------VLQTLTVAYSNDTIVTLSSLS--MFVH 195 llLpllLdvvdrimeklklRtrLkrniaelYlalveRarrkAkgyVERyG lL + ++ e+ ++n a + l + + V G TRYP10.0.0 196 VLL-TDYNYLNCYSERYQQ--NTAVNAATFGIILIASRIQR----VFQSG 238 flGLiiFvAIPLPgTGawtGaLAAyLLgIrerka.faalllGglisgavt + Li F G L L I++ ++ +l + +++ + TRYP10.0.0 239 A--LIMF------------GILCFTLSPIPRHNLkHVSLRAHVVLTFTIC 274 alpsiGiiki<-* al+ + + + TRYP10.0.0 275 ALAIYFLMEV 284 COG2891: domain 1 of 1, from 137 to 291: score -82.9, E = 25 *->mmtRfilnrwvilvsfllalvLqlvpwPyfvsyqvlrPdwLlLvLly R + ++ l +l q +p+ + +++l+P + L + y TRYP10.0.0 137 AVDR--GEIPTPFTHYLMGLCRQGIPLV--GVLILLSPVLQTLTVAY 179 wvlalphrVGigtgfimGllfDllyGslL........GvhalglsiigYl + +++ + ++ f+ ll D++y + +++ ++++ v+a ++ii + TRYP10.0.0 180 -SNDTIVTLSSLSMFVHVLLTDYNYLNCYseryqqntAVNAATFGIIL-I 227 vaknylrLrnnvllplwqqaLvvillvflvlvLiflvellimnysgFvld +++++ +++ +l+ ++++ + l+ + + + v l ++++ TRYP10.0.0 228 ASRIQRVFQS---GALIMFGILCFTLSPIPRHNLKHVSLRAHVVL----- 269 rFsptlllnillailLwPwvflLLrkvrkelrvr<-* t+ + +l++ ++L+ v+ ++ ++ TRYP10.0.0 270 ----TFTICALAI--------YFLMEVPVFALLY 291 COG1266: domain 1 of 1, from 71 to 293: score -63.1, E = 81 *->lnslmrywpnllllaallfsavilvaalivlalfvltgvalallelw + +++ y l +++ + v+ l+v++ + v +l + TRYP10.0.0 71 NVATYEYNKVVLDTFVVIQQFSFVVFYLFVFSMMLSGRVDECALMWV 117 gvlgaillllalvlllllwllglsnaaaLwvavglirqrpfslllllnkg + ++l + ++++ +++ ++ + TRYP10.0.0 118 NATLFTLAFVFCIVVQRQQAVDR------------------------GEI 143 lswrllllgllvlfaamivlfavilllllllaplsalapitvvlfalavi ++++ + l + l +++i+l +++l ll ++ + +a+ + +++l ++ TRYP10.0.0 144 PTPFTHYL--MGLCRQGIPL-VGVLILLSPVLQTLTVAYSNDTIVTLSSL 190 lialllfwvflilllfllvalaEElfFR.givggllqgaLqqrlgpvpav + ++ l+ + + + +q+ +v TRYP10.0.0 191 SM--------------FVHVLLTDYNYLnCY------SERYQQNTAVN-- 218 iiasllFallHlalgalgvsismplwllvlaafvaGlvlgllylrtg.sl ++ F+++ +a+ + + ++ a++++G+++ l + +++l TRYP10.0.0 219 ---AATFGIILIASRIQR-------VFQSGALIMFGILCFTLSPIPRhNL 258 .lvpilaHgliNgalaallvlvfllplstalglll<-* + v++ aH + ++ al ++++ +++al++ TRYP10.0.0 259 kHVSLRAHVVLTFTICALAIYFLMEVPVFALLYCV 293 COG3374: domain 1 of 1, from 101 to 296: score -104.4, E = 61 *->MallF...iDdLAmElllLvllgvlvlaaagavylfv.lkGlkdeek +++ ++++D L+ + ++++++a + v++ d + TRYP10.0.0 101 FSMMLsgrVDEC-----ALMWVNATLFTLAFVFCIVVqRQQAVDRGE 142 vkgPlaapfvg........VGllalvaGlygvmTWPLPGSyN.IlFgDPf + P+ ++ g +++ + VG l+l + +T S+ +I+ ++ TRYP10.0.0 143 IPTPFTHYLMGlcrqgiplVGVLILLSPVLQTLT--VAYSNDtIVTLSSL 190 LllGlvlLv...vAIaliKgyDlratgIiAlFaGlyaIiyavsIvnYgMT ++ vlL + + + y + A F+ I a I TRYP10.0.0 191 SMFVHVLLTdynYLNCYSERYQQNTAVNAATFG---IILIASRIQ----- 232 kePNLlaagllyIaaGLaav.LSYPtllIdrkkPGgkvvsvLevviLvia ++ +g l I +G+ +LS P I r + + L + + + TRYP10.0.0 233 ---RVFQSGAL-IMFGILCFtLS-P---IPRH---NLKHVSLRAHVVLTF 271 lllafvtgytAalGHiedvgkylpwtPivtv<-* ++ a+ + + v+ + + + +v v TRYP10.0.0 272 TICALAIYF------LMEVPVFALLYCVVVV 296 COG1684: domain 1 of 1, from 82 to 304: score -177.7, E = 85 *->MmefinlqplslvsltFlLllvRilaflstaPffserlvPavvRlgL ++f+ q++s+v+ +l ++ +++ls + a + TRYP10.0.0 82 LDTFVVIQQFSFVV-FYLFVF---SMMLS-----GRVDECALMWVNA 119 ALflsfivlPtlpasppqvpllsalyfaLlllkEiLlGlllGFilqllFa Lf+ ++v+ ++ + + + ++ + L Gl+ + TRYP10.0.0 120 TLFTLAFVFCIVVQRQ---QAVDRGEI-PTPFTHYLMGLCR--------Q 157 AfqaAGeiIsfQmGlgGfAsmvDpfsgeqtpliGqfltllalLlFLslnG + ++G +I + l+ + ++ + +++++L Ls+ TRYP10.0.0 158 GIPLVGVLILLSPVLQ-TLTVAYSN------------DTIVTLSSLSMFV 194 HllliliglldSfksiPvgsffpe.mnvlnenlf..kfllkalslmFiia H+ll + + ++++ s ++ +n++ f+ ++++ + + +F + TRYP10.0.0 195 HVLLTD------YNYLNCYSERYQqNTAVNAATFgiILIASRIQRVFQSG 238 lllalPiiialLlvdlvLGllnRaaPQlNvFviGfPLkilvGlllLilil l+ + i+++ L +P N+ +++ +++++ ++ l++ TRYP10.0.0 239 ALIMFGILCFTLS----------PIPRHNLKHVSLRAHVVLTFTICALAI 278 pviaiqfknlfllafetlrellallgkp<-* +++++ +f+l+ ++ ++++ + TRYP10.0.0 279 YFLMEV--PVFALLYCVVVVVISVVIPF 304 COG0472: domain 1 of 1, from 66 to 309: score -184.6, E = 53 *->MLlmLa.llpalss.lnlfsYltafrallalliafllsllltpifip + ++ ++ ++ ++++ t f+ ++ + +++++ ++++++++ TRYP10.0.0 66 LRQNVNvATY--EYnKVVLD--T-FVVIQQFSFVVFYLFVFSMMLSG 107 flrklaikigqdirkdgpksHkshKagTPtmGGlaIllsflivlslllwa ++ a +++ + + la++++ ++ TRYP10.0.0 108 RVDECAL--MWVN-----ATLF---T-------LAFVFC------IVVQR 134 glnsganpyevevwlvLlvllgfgliGflDDlfklsrKnnkGLsakiKll + + v D+ ++ +++ +l TRYP10.0.0 135 QQA-------V-------------------DRGEIP-------TPFTHYL 151 lqfia..AvlllilllkfdgslltqlyiPFfkspsfdlgtllylvlavfa + +++++++l +++l++ + p ++ t++y +++ TRYP10.0.0 152 MG-LCrqGIPL-VGVLILLS-------------PVLQTLTVAYSNDTIVT 186 lVgssNAvNltDGLDGLAaGlsviaalalaliaylsgnvnfAqYLlipyi l++ l++++ ++l+ TRYP10.0.0 187 LSS-----------------------LSMFVHVLLTD------------- 200 pdagelailclalaGAcLGFLwfNfyPGkAkvFMGDtGSlaLGavlgala + ++N+y TRYP10.0.0 201 -------------------YNYLNCYS----------------------- 208 vllkl.klqeilllimggvfvietlsvilqvlsrklrkdptigkrifkma +++ ++ + g+++++ + ++q + + g f + TRYP10.0.0 209 --ERYqQNTAVNAATFGIILIASRIQRVFQSGALIMF-----GILCFTLS 251 plHhHfelkgwglkftlrqflifiilcaigiLislslrllreakvvvrfW p+ H + + a+vv++f TRYP10.0.0 252 PIPRHNLKHVSL-----------------------------RAHVVLTFT 272 iislilaliglatlllaavgv.lla.vifaflrfviwlklrl<-* i++l+ +++ + v++ l v++ + + + +++++l TRYP10.0.0 273 ICALAIYFLMEVP-----VFAlLYCvVVVVISVVIPFFFVKL 309 COG1108: domain 1 of 1, from 81 to 311: score -188.8, E = 90 *->mmslLlellqyeflqnAllagllvslacgllGsflVlRRmaligDAl ++ ++++ q++f ++ l TRYP10.0.0 81 VLDTFVVIQQFSFVVFYLF---------------------------- 99 SHaaLpGvalgyLltgqlglfllginpllgaiafgllgAlligflrrksk +++++l+g + + + a +f+l + ++i+ r+ TRYP10.0.0 100 --------VFSMMLSGRV--DECAL-MWVNATLFTLAFVFCIVVQRQQAV 138 vkeDtaiGivfssglal...GvvllsllpgfnnsavdlmnyLFGniLaVs ++++ + + ++l ++G+ l+ +l l+ L + L+V+ TRYP10.0.0 139 DRGEIPTP-FTHYLMGLcrqGIPLVGVLI-------LLSPVL--QTLTVA 178 ptDLwliaivslGPsVlclvllllllfyrelllisFDpefAkvlGipvrl + +++ sl s ++ +ll y+ l + ++ + + + v++ TRYP10.0.0 179 YSNDTIVTLSSL--SMFV---HVLLTDYNYLNCY--SERYQQ--NTAVNA 219 lhyllllLialtiVaavkaV...GviLvsaLL..iiPaatArllsrslrs + ++l i++ ++ V ++G+++++ +L ++ ++ +l++ TRYP10.0.0 220 ATFGIIL-----IASRIQRVfqsGALIMFGILcfTLSPIP----RHNLKH 260 mliiAillgllsgvlGvlllSyyldlppGpsivliatllfllslllrkky + + A ++ l +++++ l ++++ +p+ ++ + ++ +++ ++++ TRYP10.0.0 261 VSLRAHVV-LTFTICA-LAIYFLMEVPVFALLYCVVVVVISVVIPFFFVK 308 gvl<-* + TRYP10.0.0 309 LHG 311 COG0575: domain 1 of 1, from 112 to 312: score -126.6, E = 52 *->mlkqrlitalilaplvgsfllllilrfalfallllalrlvalwemtr + ++++l+++++v f++ + a + + + +++ l ++ r TRYP10.0.0 112 CALMWVNATLFTLAFV--FCIVVQRQQAVDRGEIPTPFTHYLMGLCR 156 lvgvelrlkrvavillflllmlllvvallpavllgggdkilakfllwlpl + ++++ +l+l+ +++ l+ a+++ + TRYP10.0.0 157 ---------QGIPLVGVLILLSPVLQTLTVAYSNDT-------------- 183 ilgilpldwgllflllvrtygkgltftgpvtglFacvvllgdtvgflfsa i+++ +l ++ +ll + y++++ ++ + TRYP10.0.0 184 IVTLSSLSMFVHVLLTDYNYLNCYSERY-------------------QQ- 213 gkalgallltvlpilflllllrlfqiggyyltplrgallll.llmigvwa a+ a+++ +++i++ r+ +++gal ++++l+++ TRYP10.0.0 214 NTAVNAATFGIILIAS-----RIQ------RVFQSGALIMFgILCFTLS- 251 aDigAYFiGklFGKtklaPkISPnKTvEGfigGlllavlvgslfglilgy ++ l ++S + +l++++ ++ +++ TRYP10.0.0 252 ----------PIPRHNLK-HVSLR------AHVVLTFTICALAIYF---- 280 pyilfllqnlllallitnlffivllvvlsfyywWvsTLaLilfSlfsvlG l+ +++ all+ +vv+ TRYP10.0.0 281 -----LMEVPVFALLYC-------VVVV---------------------- 296 DLfeSalKRdagvKDsgkllPGHGGiLDRiDSllftAppffafllileg< ++S +++ f+f+++ ++ TRYP10.0.0 297 --VIS-------------------------------VVIPFFFVKLHGS 312 -* TRYP10.0.0 - - COG0730: domain 1 of 1, from 90 to 313: score -117.8, E = 30 *->mmnlalllllflvGfiaGfla..glfGiGGGlllvPaLlflgglpph +++++ l+++ ++ G +++ +l ++ + l+++ + + + + TRYP10.0.0 90 QFSFVVFYLFVFSMMLSGRVDecALMWVNATLFTLAFVFCIV-VQRQ 135 vAvGTsllqvlftalssayahlkkgnvdlklglilglgsvvGaalGalla +Av + + ft h+ g++ + g++l+ + ++ +++ l+ TRYP10.0.0 136 QAVDRGEIPTPFT-------HYLMGLC--RQGIPLVGVLILLSPVLQTLT 176 klipaeikyeaLklifgllllllalymllskkieikpkreekpnkkslpl + + +++l++l m+ + + +l TRYP10.0.0 177 VAYSNDT-----------IVTLSSLSMFVH-----------VLLTDYNYL 204 pglggfyep.leieyavrawlliliGfliGflsGllGiGGGsllvPaLil ++y +++ +++++ ++++Gi +Li TRYP10.0.0 205 ----NCYSErY----QQNTAVN----------AATFGI--------ILIA 228 llgyslplkkavgtsllaialsslisfllyllggpvdwllalglvlGsii + + +g ++ +l + s + + +v+++ ++l++ i TRYP10.0.0 229 SR---IQRVFQSGALIMFGILCFTLSPIPRHNLKHVSLRAHVVLTFT--I 273 GaylGarlasrkligprflrllfalilllvalklllkglgmll<-* a++ +l+ ++ +l + ++++ v + +++ l++ + TRYP10.0.0 274 CALAIYFLME---VPVFALLYCVVVVVISVVIPFFFVKLHGSM 313 COG1612: domain 1 of 1, from 1 to 314: score -165.4, E = 87 *->fLfrlievlRlaiklleetvkrlairsigrdralslmrrrlrrlawl + + +lR e r i s++ a+++ + r+ r +++ TRYP10.0.0 1 MRNCQPASLRETSAMGEAAQPRGTIGSVSTETATVRDEGRVWRKVLY 47 ................................tviltfllivlGaitRlT ++++ +++ ++++ ++ +++ + + + +++v+ tf++i + +++ + TRYP10.0.0 48 trqpyednyvdpqqflqdlrqnvnvatyeynkVVLDTFVVIQQFSFVVFY 97 gAGlgCGpdWPlCnGqlfPfqspaevpefakykpvpelellNydIdLdeF ++f + + v TRYP10.0.0 98 -----L---------FVFSMMLSGRVD----------------------- 110 KFqtiiEwiHRllagltGllvlglallAwrrrrfvisrevklaallalal + ++ w++ + ++ l+ + +++ r+ + v ++e++++ + l TRYP10.0.0 111 --ECALMWVN----ATLFTLAFVFCIVVQRQQA-VDRGEIPTPFTHYLMG 153 lilQal.LGgwtVtlgLlapivalHlgylaavlilavlvllllllqdakv l+ Q+++L g+ +l+ +++++++ ++++l++l + + +l+++++ TRYP10.0.0 154 LCRQGIpLVGVLILLSPVLQTLTVAYS-NDTIVTLSSLSMFVHVLLTDYN 202 vrdgVeplllvkkklrplala.sitilyaqillGalVaaagAalacldaa + l + ++ ++++++t ++++i+ + +++ +al TRYP10.0.0 203 Y------LNCYSERYQQNTAVnAATFGIILIASRIQRVFQSGALIM---- 242 WvvnnfPlcggewvPiElrddfangfelkkdiGvryllgeiefvqviHrt f TRYP10.0.0 243 ------------------------------------------F------- 243 lavvlfalllvll.vwllrkratrernvLvwlavllllvllaQvllGilt +l+++l ++ + +++ +r v + + ++l++ TRYP10.0.0 244 -----GILCFTLSpIPRHNLKHVSLRAHVVLTFTICALAI---------Y 279 vllgvpialvAvaHalvaiaLlavlvllayllrrpeavtr<-* +l +vp + ++l ++ + ++v++ + +++ ++ + TRYP10.0.0 280 FLMEVPVF-----ALLYCVVVVVISVVIPFFFVKLHGSMK 314 COG0555: domain 1 of 1, from 98 to 316: score -194.7, E = 79 *->lpgfwlllglg....allfl..llfllLPliaifsralglgwalfla l++f l+ + ++ al++++ lf l ++ i+++ ++ ++++ TRYP10.0.0 98 LFVFSMMLSGRvdecALMWVnaTLFTLAFVFCIVVQRQQAVDRGEIP 144 aildPdvlaAlklsLltAliatllnlvfGvplAwvL....aRfeFpGKrl + ++ + +++ ++l++v+ ++l+ vL++ ++ ++ TRYP10.0.0 145 TPFTHYLM-------GLCRQGIPLVGVL-ILLSPVLqtltVAYSN----- 181 ldalidLPlvLPPvVaGlaLlllfGrnGplGqwledvfGiqivFswpGiV d+++ L + + +l + l+ ++e ++ + V TRYP10.0.0 182 -DTIVTL------SSLSMFVHVLLTDYNYLNCYSER-YQQNTA------V 217 lAqlFVslPFvVrelqpvlesvdrelEeAArtLGAspwqt..FfrVtLPl A +F + +++ +q v++s + + + ++ +sp+ +++ +V+L + TRYP10.0.0 218 NAATFGII-LIASRIQRVFQS-GALIMFGILCFTLSPIPRhnLKHVSLRA 265 ilpgllaGviLaFARalGEFGAVlmvaGNIpGkTrTlPlaIylalesgdy v+L+F + a laIy ++e TRYP10.0.0 266 H-------VVLTFT----------ICA-----------LAIYFLMEV--P 285 eaAfalavvLlliSlivLlllnilggrqrrsgrr<-* A ++vv ++iS ++ ++ +l ++++ TRYP10.0.0 286 VFALLYCVVVVVISVVIPFFFVKL---HGSMKDQ 316 COG1183: domain 1 of 1, from 130 to 316: score -127.7, E = 12 *->rriesiksikyqSldr.....snvskeflmnglemkvrifriyllPn i+ q dr++ ++++ + ++ + + ++ i+l P TRYP10.0.0 130 -----IVVQRQQAVDRgeiptPFTHYLMGLCRQGIPLVGVLILLSPV 171 lfTalnlfsGlyaIlsalsgtpsseltprwqyqlAailiflamifDGLDG l T+ + s +++ +++++ TRYP10.0.0 172 LQTLTVAYSNDTIVTLSSLS------------------------------ 191 rVARktnvlasSpFGaeLDSLaDvisFGVAPAllaYkaalgtfpgtifGk +++++ l ++ TRYP10.0.0 192 ---------------------------------MFVHVLLTDY------- 201 fgllvaflyvlCgaLRTHLYLARFNvlvgkgpqvcdsryFiGlPiPaAAa + l + ++ ++ N+ v+ ++++ TRYP10.0.0 202 -----NYLNCYSERYQ-------QNTAVNAA--------------TFGII 225 livglvlldnsygiliatedtrilllvlalifgavLMvSnIrypsfkkls li++ ++ +++ g li +++l+ + + S I+ +++k++s TRYP10.0.0 226 LIASRIQRVFQSGALIM----FGILC--------FTL-SPIPRHNLKHVS 262 asankstiEniSavsaLlvflaliaiilalvilqpsfvllilalsyllsg ++a +++ + ++a+++ +++ +p f+ll ++ +++s+ TRYP10.0.0 263 LRAH------------VVLTFTICALAIYFLMEVPVFALLYCVVVVVISV 300 pivylrriikrkrkqs<-* +i +++ + k+ TRYP10.0.0 301 VIPFFFVKLHGSMKDQ 316 COG0697: domain 1 of 1, from 84 to 316: score -115.9, E = 96 *->llgllllllaaliWGssfvliKlaledgnyrifvvppltivflRfli + ++ + +++++ fv++ ++++ v+ +++++ ++ TRYP10.0.0 84 TFVVIQQFSFVVFY--LFVFSMMLSGR-------VDECALMWVNATL 121 aallLlpllllrrrlprr.pgkllllglgsnvetlllllglllglflyfl +l++++ + +r + ++g++ TRYP10.0.0 122 FTLAFVFCIVVQR-QQAVdRGEIPTP------------------------ 146 lffyalqytsasvaalltslaPlftallaflllgerltrlqllglllafl f+ l+++ ++++l++ l++++l l l++l f+ TRYP10.0.0 147 -FTHYLMGL-CRQGIPLVGVLILLSPVLQTLTVAYSNDTIVTLSSLSMFV 194 Gvvllll.lggllllGillaLlaalswAlytvlgkrlsarvprptplplt +ll++ l+ +s+r+ ++ TRYP10.0.0 195 H--VLLTdYNYLNC----------------------YSERY-------QQ 213 ivflqlllgallllplalflggpplssptlpspfielsfwlallylgvla ++ +++ ++ +++a ++ ++s g l TRYP10.0.0 214 NTAVNAATFGI--ILIASRIQRVFQS--------------------GALI 241 talgyllwnyalrrlgaskaallsylePvfalllgwllLgErpltlaqll +++ + + + r + ++l ++ f++ + ++++ ++ ++ll TRYP10.0.0 242 MFGILCFTLSPIPRHNLKHVSLRAHVVLTFTICALAIYFLME-VPVFALL 290 GaalilaGillvslrarkrarkaase<-* ++++++ +++ ++ k + +++++ TRYP10.0.0 291 YCVVVVVISVVIPFFFVKLHGSMKDQ 316 COG0772: domain 1 of 1, from 43 to 316: score -261.8, E = 90 *->rklkqrrhl.....tDrlLllllllLllliGlvmvySassavladrs rk+ ++r+ +++ D++++l l + a+++++ + + TRYP10.0.0 43 RKVLYTRQPyednyVDPQQFLQDLRQNV-------NVATYEYNKVVL 82 gngdphfffirQlvylilGlilmflllriplrklflkkwspllylvsllL + f +i+Q ++++ l+++ ++l + + ++l++ l+ +++++ TRYP10.0.0 83 DT----FVVIQQFSFVVFYLFVFSMMLSGRVDECALMWVNATLFTLAFVF 128 LvlVlffGvglapevnGAkRWirlGggfsiQPSEfvKlalilfLAyyLsr +++V + ++ ++ TRYP10.0.0 129 CIVVQRQQA-V--DRG------EIP------------------------- 144 kqellslppvllrslfrg.lrtflkpllvvvipalLIllQPDLGTavvll + p+ +++++g r+ +++++v LIll TRYP10.0.0 145 -T------PF--THYLMGlCRQGIPLVGV------LILL----------- 168 iiglfmlFlaGvplrlvlaifillillallilifvpfiiifsggsfllkp +l v ++ ++ l+ +++fv ++++ TRYP10.0.0 169 ---SPVLQTLTVAYSN----DTIVTLSS--LSMFVH--VLLT------D- 200 YqkkRvtsfLdPeaDplGsGYQiiQSliAIGsGGlfGkGlgnGtqsKlgy +L+ ++ ++ YQ + + +A fG l +++ ++ + TRYP10.0.0 201 ------YNYLNCYS-ER---YQQNTAVNAA----TFGIILIASRI-QRVF 235 LPEahTDFIFAvigEEfGfiGvlllLaLffllilrglrIalrAlaatdlF + a L++f+ l +++ I ++ l + +l TRYP10.0.0 236 QSGA---------------------LIMFGILCFTLSPIPRHNLKHVSLR 264 gkllAsGitlliffQvfvNiGmvsGLLPvtGvpLPfiSYGGSSllstmia + ++ ++ +++++++ + + l +++ TRYP10.0.0 265 AHVVLTFTICALAIYFLMEVPVFA--------------------LLYCVV 294 iGiLlnisresRahryrvmrlgkke<-* + ++ ++ + + +++ ++k++ TRYP10.0.0 295 VVVISVVI---PFFFVKLHGSMKDQ 316 COG1682: domain 1 of 1, from 43 to 317: score -131.1, E = 40 *->flalklledirsllryrrliltLvkrei.kqRY.rrsvLGvlWslln +++l +++ +++ +l+ ++++++ + Y+ + v + ++++ TRYP10.0.0 43 RKVLYTRQPYEDNYVDPQQFLQDLRQNVnVATYeYNKVVLDTFVVIQ 89 PflmilvytliFgfllrsrlgvvalggldyviylfaGllpwfffseslsr f+ ++ y ++F+++l g++d + + + ++ +l TRYP10.0.0 90 QFSFVVFYLFVFSMMLS--------GRVDECALMWVNATLF-----TLAF 126 gagsfvananlikklnikPl.svlplatilanlfnfligisviililliv ++v + + + i P +++++l + ++++ ++ + +++ ++l + TRYP10.0.0 127 VFCIVVQRQQAVDRGEI-PTpFTHYLMGLCRQGIPLVGVL-ILLSPVLQT 174 fgvlpswqllllplallllv.lfvfglg.................lflas + v s + ++ +++l +v+++++ + + +++ ++++ + +++ TRYP10.0.0 175 LTVAYSNDTIVTLSSLSMFVhVLLTDYNylncyseryqqntavnaATFGI 224 lsvfgfRDigqilglltqvlFflsPIi.ypvsilqlPekvspllylNPll + + +i ++ ++++ +I +++s+ +P+ ++ + l + TRYP10.0.0 225 ILIA-----SRIQRVFQSGALIMFGILcFTLSP--IPRHNLKHVSLR--A 265 hiieivRaillggdlpidlesf.lyillltllllllGllffrklekrfvd h++ ++ l ++ +++ + f l ++++++++ + +ff kl ++d TRYP10.0.0 266 HVVLTFTICALAIYFLMEVPVFaLLYCVVVVVISVVIPFFFVKLHGSMKD 315 vL<-* ++ TRYP10.0.0 316 QI 317 COG1177: domain 1 of 1, from 105 to 317: score -204.0, E = 70 *->mssarsrwrlsflraflwlvlaFLYLPllilvlySFNtssklgtvwq +s + +++l+ ++a l +laF + +v++ + ++g +++ TRYP10.0.0 105 LSGRVDECALMWVNATL-FTLAF----VFCIVVQRQQ-AVDRGEIPT 145 GFTnpNLkWYaeLfqdedllsAaaNSLlIAvlsalvatvlGtLAAfALwR FT +Y + + ++ + l++vl +l++ vl tL+ +A TRYP10.0.0 146 PFT-----HYLMGLCRQGIP-------LVGVL-ILLSPVLQTLT-VA--- 178 yrfrgknlvsgllllPlvvPdIvtGvsLLllFatwtaiglqLG...Wpq. ++n d + +s L F+ + L + + + TRYP10.0.0 179 ----YSN-------------DTIVTLSSLSMFV-----HVLLTdynYLNc 206 ......drgfftiilaHitFclPfVyvvisaRLqgldlsLieAAaDLGAs +++ + ++ + +tF++ ++i +R+q++ + TRYP10.0.0 207 yseryqQNTAVNA----ATFGI----ILIASRIQRVFQ------------ 236 pwqtFfkitLPllaPgIlsGaLLAFtLS...lDDFViTsFvsG.VpTiGs +++ ++L FtLS+ + ++ s+ + V ++ TRYP10.0.0 237 -------------SGALIMFGILCFTLSpipRHNLKHVSLRAHvVL--TF 271 etLPlqifsmirrGvvsPeiNAlatllllvlslllviasyllgvkrlekr ++ l i+ + ++v + + ++++++ +++ +++ + + +++ TRYP10.0.0 272 TICALAIYFLMEVPV-FALLYCVVVVVI-SVVIPFFFVKL-----HGSMK 314 rer<-* + TRYP10.0.0 315 DQI 317 COG1294: domain 1 of 1, from 81 to 318: score -223.5, E = 81 *->emmmleyelLpliWwvLlgvlivgyvvlDGFDlGVGillpllgkdek + ++ ++++ +v++ ++++ + l+g+ ++ TRYP10.0.0 81 VLDTF--VVIQQFSFVVFYLFVFS--------------MMLSGRVDE 111 eRriliNSIgPvWDgNeVWLVlaGGALFAAFPlaYAtlfSgLYlPliliL + + +N Atlf+ l++++ + TRYP10.0.0 112 CALMWVN----------------------------ATLFT---LAFVFCI 130 llLIlRgvaFefRsKidkprwkkvwDisfiiGslipalliGvapvsfGnl + ++v R+ i++p + ++ + + ip + ++ ++ + TRYP10.0.0 131 VVQRQQAVD---RGEIPTP---FTHYLMGLCRQGIPLVGVLIL---LSPV 171 ieGvPvdlnellrvswqhftgslfdllnPFalLcGLalvslfllhGaawl +++++v++ + v ++sl + v ++l+++ ++l TRYP10.0.0 172 LQTLTVAYSNDTIV----TLSSLSMF------------VHVLLTDY-NYL 204 qlkTegeLqrRaakvaqiisllvavlfllfglwtplgidgyvvnsiDhna e q+ a + a ++++l++++ ++ g+++ TRYP10.0.0 205 NCYSERYQQNTAVNAAT------FGIILIASRIQRVFQSGALIM------ 242 fsnPlNKeVareaGAWlynfpnvpilwalpvlgvalplllmvqgkkvlsv f ++ ++l ++p + + l TRYP10.0.0 243 FG------------------ILCFTLSPIPRHNLKHVSL----------- 263 rikkdglAF.vltvlqfalailgagislfPnlmpSsldPqysLTiwnAaS + +++l+F+++++++++l + + +l+ +++ TRYP10.0.0 264 -RAHVVLTFtICALAIYFLMEVPVFALLYCVVVV---------------- 296 spyTLkvMlivaliglPiiLaYtiwsYrvFrGkvdkryiyrneh<-* ++ +++P F++++ + + ++ + TRYP10.0.0 297 ---------VIS-VVIP------------FFFVKLHGSMKDQIN 318 COG3371: domain 1 of 1, from 146 to 319: score -100.6, E = 61 *->miknyamtp..kmlkilgiigpliail.gilisvllNrpWFSfTkNA y m++ + ++g++ l+ +l+++ ++++ T TRYP10.0.0 146 PFTHYLMGLcrQGIPLVGVLILLSPVLqTLTVAYSND------TIVT 186 LSDLGggnLLqnGHvkapkpWvyNyGLIigGvlvllfSvdlgilalkk.s LS L Hv +++ yNy + + + + +++ + TRYP10.0.0 187 LSSLSM-----FVHVLLTD---YNY---LN--C---Y---SERYQQNTaV 217 enlgralliiSglFLaLIGvFpEGtGrpHvfvSilFFilmfiamlilSvr +++ +++++i++ vF G + il F l++i ++ TRYP10.0.0 218 NAATFGIILIASRIQR---VFQSGA---LIMFGILCFTLSPIPRHN--LK 259 ASLPAWiRvygisrlirklaigifgLalfivyilvfiplgwvSlAvpEli ++r+ +++f++ ++ +y+l ++p+ A+ + TRYP10.0.0 260 ------------HVSLRAHVVLTFTICALAIYFLMEVPVF----ALLYCV 293 gialIlaiv..iflglryllkrVkdg<-* +++I +++ +f+ l++++k g TRYP10.0.0 294 VVVVISVVIpfFFVKLHGSMKDQING 319 COG2814: domain 1 of 1, from 69 to 320: score -307.8, E = 89 *->masstkaqkskklallallaLAlaaFaiGttEFvpvGLLpdiAadlg + ++++ k +++ Fv+ i++ TRYP10.0.0 69 NVNVATYEYNK----------------VVLDTFVV------IQQ--- 90 vsiaaAGqLislYAlgvalgaPlLtlltarleRKrlLLgllalFivsNll ++++v+ + ++l++r++ +L++ a ++ TRYP10.0.0 91 ------------FSFVVFYLFVFSMMLSGRVD-ECALMWVNATLF----- 122 sAlApnfalLllaRilsAlahGvFwviaaalAariVppekrgrAlalift ++a++ iV ++++ TRYP10.0.0 123 ---------------------------TLAFVFCIVVQRQQA-------- 137 GltlAlvlGvPLGtflGqlfGWRaaFlaiallallvllllarlLPsipgs +g TRYP10.0.0 138 ---------------------------------------------VDRG- 141 araekpgslrsqlrllrrprvllillatilwigGhFtlYTYiaPfLqeva e p+++ ++l+ l r++++l+ ++++l +P+Lq+++ TRYP10.0.0 142 ---EIPTPFTHYLMGLCRQGIPLVGVLILL------------SPVLQTLT 176 GfsgatvtllLLvfGlagivGnllgGr.....ladrlGprrtllgvllll ++++ ++L l+++v ll ++ + +++r+ ++ ++++ + TRYP10.0.0 177 VAYSNDTIVTLSS--LSMFVHVLLTDYnylncYSERYQQNTAVNAATFGI 224 alvlllLplaagslilalaalflWGlaafsagpalQtrvarlapRdaadv +l++ ++ +al+ +++ +++++ ++ +v+ a+ TRYP10.0.0 225 ILIASRIQRVFQ--SGALIMFGILCFTLSPIPRHNLKHVSLRAH------ 266 aaslnvaAfNlGialGAalGGlvldrglGlaalpwvGAaLvllAlllall + l +++ l+i ++l + ++ + ++v++ ++ ++ TRYP10.0.0 267 -VVLTFTICALAI--------YFLME--VPVFALLYCVVVVVISVVIPFF 305 aarskkktaaepsll<-* + + ++ + + + + TRYP10.0.0 306 FVKLHGSMKDQINGP 320 COG0385: domain 1 of 1, from 80 to 321: score -215.9, E = 4.2 *->ysliRmnilrkisrFlsktFtlwliilvllAfffPdffttlgpfeGQ +l+ + + s ++ F l++ + l ++ + + ++ TRYP10.0.0 80 VVLDTFVVIQQFSFVV---FYLFVFSMMLSGRVDECALMWV------ 117 YslipilLglImFgmGLtLtpeDfrevlrhPravligliaqfvimPllaf +++ L+++ f +v+++ +av g i + P + + TRYP10.0.0 118 -NATLFTLAFV------------FCIVVQRQQAVDRGEIPT----PFTHY 150 llskllkanNDPKldPelavGliLvgacPgGtaSnnvmTyLakGNVaLsV l + + G+ Lvg++ TRYP10.0.0 151 LMGLCR--Q-----------GIPLVGVL---------------------- 165 avtsvsTLLsplltPLlvnLftaYlaGdNPATgeglpvdflgmvkqillm +ll+P l L +a+ + +++++l+m++ +ll TRYP10.0.0 166 ----------ILLSPVLQTL---TVAY---SNDTIVTLSSLSMFVHVLLT 199 VlvPiaLGmlvqNCFrkflpkvveklkkvLplvSvlsillIIaavfsaaa + +++l + e+ + + + +++ + II++++ + TRYP10.0.0 200 -----------D---YNYLNCYSERYQQNTAVNAAT--FGIILIASRIQR 233 engashlvesglliflvVllhnllGllLGLSYLCARPWFILKLFPHEPIE ++ +sg+li+ l++ l+ + TRYP10.0.0 234 VF------QSGALIMFGILCFTLSPIPRH--------------------- 256 GKSTRLYRYltakllgLdyskrkaItIevGGPmqNsgLgaALAtaqhffp l +++ + +t++++ A+a ++f TRYP10.0.0 257 ------------NLKHVSLRAHVVLTFTIC------------ALA-IYF- 280 tshlplmAvPl..aIfsvwqnltaavLasLlKryirRtaqataaqssaad lm vP+ ++ v+ +++++v ++ +++ + + q + TRYP10.0.0 281 -----LMEVPVfaLLYCVVVVVISVVIP----FFFVKLHGSMKDQINGPW 321 <-* TRYP10.0.0 - - COG0341: domain 1 of 1, from 28 to 322: score -226.5, E = 79 *->llldtgpIkgf..aLtlavglfsalftAlfmtdflftlder.tlgm. t + ++ +++ ++ + + + ++ + + TRYP10.0.0 28 VSTETATVRDEgrVWRKVLYTRQPYEDNYVDPQQFLQDLRQnVNVAt 74 .qlfkmklfv.gikidFmkwrkvafivS..........gllllisifslf + +k++l + +++ F + + f +S +++ ++ +l+ + + ++ + TRYP10.0.0 75 yEYNKVVLDTfVVIQQFSFVVFYLFVFSmmlsgrvdecALMWVNATLFTL 124 fkGlnvfGiDFtGGtlielqfesasnyfeqsadieqvrealeaagk.fgd + + i +q +q++d +++ + ++ TRYP10.0.0 125 AFVFC-----------IVVQR-------QQAVDRGEIPTPFTHYLMgLCR 156 vsvqsfGsngsdisirlkssd..gsdelvk.r.kvqeaLkk.sgdgevrs + + +G+ +s +l++ + +s++++ + + + +++ d+ +++ TRYP10.0.0 157 QGIPLVGVLI-LLSPVLQTLTvaYSNDTIVtLsSLSMFVHVlLTDYNYLN 205 iefVGPtVGkeLreqgllAvlfALigIliYVglRFewrfaSlaAIlAlfH + ++ ++++ Av +A gI++ ++ R + f S TRYP10.0.0 206 CY------SERYQQNT--AVNAATFGIIL-IASRIQRVFQS--------- 237 DviitlGfmSlfgFflkiEvdlatiAAlLTvIGYSlNDTIviFDRiREnf G++ +fg I+ F+ + TRYP10.0.0 238 ------GALIMFG--------------------------ILCFT-----L 250 rkkkkrkktlaeivNeSinqTLsRTinTslTTllvvlaLllFGpvGgslk +++++l ++ ++ +lT+ + +la+++ + + ++ TRYP10.0.0 251 S--PIPRHNLKHVSLRAHV---------VLTFTICALAIYFLM-EVPV-- 286 dFslaLlvGiivGTYSSifiAsplllwlgkkrsekklkpqak<-* +aLl ++v + S + + + ++l ++ + +++ + + TRYP10.0.0 287 ---FALLYCVVVVVIS--VVIPFFFVKLHGSM-KDQINGPWD 322 COG2245: domain 1 of 1, from 152 to 323: score -101.7, E = 51 *->vikMeLsn..AKllgGiGaiLqLvGaavgllGi......LiwiLSiv M L ++++l g +L L ++++ +l + +++++ + S+ TRYP10.0.0 152 ---MGLCRqgIPLVG----VLILLSPVLQTLTVaysndtIVTLSSLS 191 GlVLvLialymISkqvgddrIFnyyLigfismvaglilfvivifAtvGvs +V vL+ y+ ++ n ++ + g+il+++ i TRYP10.0.0 192 MFVHVLLTDYNYLNCYSERYQQNTAVNA---ATFGIILIASRIQR----- 233 ivallkksmmslahglaalgsiLaGfViLyIayiigtyFqkKsyEliAqy +++++ + + + + l++i + + ++ + TRYP10.0.0 234 VFQSG--ALIMFGILCFTLSPI-----------------PRHNLKHVSLR 264 TgVdm.FrtAGL.lYf.....iGaiLLIVlGvGflilliAaILeiVaFFS V ++F +++L +Yf + ++ a+L V+ + i + F TRYP10.0.0 265 AHVVLtFTICALaIYFlmevpVFALLYCVV-----VVVISVVIPFF-FVK 308 LPdEikaseqaaVsp<-* L k + + + TRYP10.0.0 309 LHGSMKDQINGPWDE 323 COG1113: domain 1 of 1, from 58 to 326: score -415.3, E = 18 *->Mdpslvmaddnqda...eqeLkRgLknRHIqlIAlGGAIGTGLFlGS dp+ + +d +q+ + e+ + TRYP10.0.0 58 -DPQQFLQDLRQNVnvaTYEYNK------------------------ 79 gsaIqmAGPsvlLaYaIaGlivflIMRaLGEMavanPvaGSFsdYArkyl ++++ +f + ++ SF+ + TRYP10.0.0 80 -VVLD----------------TFVVIQQF-----------SFVVF----- 96 GpwAGFltGWlYWflWvlvgmaElTAvgiYmqyWfpaFPdvPqWiwALia +l f+++l g ++ A W TRYP10.0.0 97 ---------YLFVFSMMLSGRVDECAL-----MW---------------- 116 lvlllavNLisVKlFGElEFWFAlIKVaAIvafIvlGlvllfggfggggt vN + ++ l+++f + + TRYP10.0.0 117 ------VNAT------------------------LFTLAFVFCIVVQRQ- 135 GfsNLwahtGGFFPnGllGlllalqvvvFAFgGiElvGitAgEakdPeks + G P+ ++ l++l+ +Gi lvG TRYP10.0.0 136 ---QAVDR-GEI-PTPFTHYLMGLCR-----QGIPLVG------------ 163 ipkAinsViwRIliFYvGslfvilslyPWnqvgsggsgSPFVtvFskiGi v+++l P q + + + TRYP10.0.0 164 ---------------------VLILLSPVLQTLTVAYS----------ND 182 paAasImNfVVLTAAlSslNSGlYstsRMLysLAeqGdAPkffaklsrrG ++++ lSsl s ++ L + + +++++ ++ TRYP10.0.0 183 TIVT-----------LSSL-------SMFVHVLLTDYNYLNCYSERYQQN 214 VPvnAillsavvlllgVlLNYvaPsvekvFelltsssglgalfvWlmIll vnA + ++ ++a ++vF sg++++f l l TRYP10.0.0 215 TAVNAATFGII---------LIASRIQRVFQ-----SGALIMFGILCFTL 250 sqLkfRkarkpaqgaalkFkmpLyPfttyltlaFllfvLvlMafdpdtRi s ++++++++ + ++ ++l F ++L + ++++ TRYP10.0.0 251 S------PIPRHNLKHVSLRAH-------VVLTFTICALAIYFLMEVPVF 287 slfvtpiwlvl.LvigYlvfgkrrkaeahgarpv.kaee<-* +l+ ++ v+++vi +++++++ ++ + p+++a++ TRYP10.0.0 288 ALLYCVVVVVIsVVIPFFFVKLHGSMKDQINGPWdEAKP 326 COG0798: domain 1 of 1, from 56 to 329: score -244.7, E = 47 *->MSedqksEnsvksmvnrvnrtmklkemKrLsfLdkfLtlwiflaiai q+ ++ ++ vn+ + ++ + ++ f ++ +f + + TRYP10.0.0 56 YVDPQQFLQDLRQNVNVATYEYNKVVLDTFVVIQQF-SFVVFYLFVF 101 GiylGvvvpsvaltldslGHPqldtvSlPiAiGLilMmYPpmakVryEel + l+ v + al ++ + + +A+ ++ + + TRYP10.0.0 102 SMMLSGRVDECAL---MW----VNATLFTLAF----------VFCIVVQR 134 knvfkasvkrKlLilsLalNwvigPlLMfilawvfLrdlpePLLtAtEii +++ + + + P++ + L+ l TRYP10.0.0 135 QQAVDR-------------GEIPTPFTHY------LMGL----------- 154 RGqEvtldheyriGlILiGlApCiAMVivWngLakGdrelAlVlVAfNsL r+G+ L+G+ + + V+ a+++ +V ++sL TRYP10.0.0 155 ----------CRQGIPLVGVLILLSPVLQTLTVAYSNDT----IVTLSSL 190 lqivlyavyayifitvlphwLglvegtsiavsieeiaKSVlIyLGiPLia + v + + y ++ ++ ++t+++ + i++ TRYP10.0.0 191 SMFVHVLLTDYNYLNCYSERYQ--QNTAVNAATFGIIL------------ 226 GilTRyillriKGrewyesrilpklSpiaLiaLl.ftIvviFslKGklIV i++R + r + s +++ + + l ft++ i + k TRYP10.0.0 227 -IASR--IQR-----VFQS------GALIMFGILcFTLSPIPRHNLKHVS 262 erPldilliAliPLliYFlimffitfllgyaLglsRsDtqRECsCDqELL r ++++l + +i ++++++l+ ++ TRYP10.0.0 263 LR-AHVVLTF--------TICALAIYFLM---EVP--------------- 285 LkRvWGRksCEAsYedttalaFTaaSNNfeLAIAvAvalFGigSgaAiAA +F+++ + TRYP10.0.0 286 --------------------------------------VFALL----YCV 293 vvGPLiEVPvLigLVkvCkktallirkkyiknirksps<-* vv +i V + ++Vk+ i + + + ++++s TRYP10.0.0 294 VVV-VISVVIPFFFVKLHGSMKDQINGPWDEA-KPTNS 329 COG2364: domain 1 of 1, from 95 to 329: score -150.7, E = 30 *->mLAskkkvrllsRtasaAallkkelllrwliyliGLlilglGisLtI + + +ls + al++ + L +l++ + TRYP10.0.0 95 VFYLFVFSMMLSGRVDECALMWVN---------ATLFTLAFVFCIVV 132 qGsgLGs......sPWDvLhvGLsqqfGLtVGsWSIligfclvgltallt q + +++++ ++P++ + GL q VG + Il++ +l lt TRYP10.0.0 133 Q-RQQAVdrgeipTPFTHYLMGLCRQGIPLVG-VLILLSPVLQTLTVAYS 180 rerPglGtLLNmlliGvFIDiflflihnfItPeal....vsrlIcfliGl + L m+ + v + +++l + e +++++++ + f+i l TRYP10.0.0 181 NDTIVTLSSLSMF-VHVLLTDYNYLNC---YSERYqqntAVNAATFGIIL 226 v............LiGlGtglYltaglGAGPrDgLMLgIaektgwnvqfv + ++ ++ +++ Li +G+ l l ++Pr L + +++ TRYP10.0.0 227 IasriqrvfqsgaLIMFGI---LCFTLSPIPRHNL--------KHVSLRA 265 RtlvEilvLllg..wlLGGPiGlGTvLfacLiGlilqFfLpiigrlldYl ++ ++++l+ +l+ P++ +L + + + p + + l++ TRYP10.0.0 266 HVVLTFTICALAiyFLMEVPVFA--LLYCVVV-VVISVVIPFFFVKLHGS 312 lerGiRyeakeekalrkvH<-* + + + a ++ TRYP10.0.0 313 MKD--QINGPWDEAKPTNS 329 COG1174: domain 1 of 1, from 1 to 330: score -222.5, E = 70 *->yap.nrlvlgeGRalaalalq..tiwaLvavgaAllaaGfiPak..g ++ + l e+ a+ +a++++ti +a G ++ k TRYP10.0.0 1 MRNcQPASLRETSAMGEAAQPrgTIGSVSTETATVRDEGRVWRKvlY 47 sivalilayv...vfdtlvkfllplan......qvaefvDwlvttfggfF ++ + yv+++ f+ +++ a+ + ++ ++ fv +f +F TRYP10.0.0 48 TRQPYEDNYVdpqQFLQDLRQNVNVATyeynkvVLDTFVVIQQFSFV-VF 96 dgisdtlalliggfkqlllflpllllillfallalvasalglallallst ++ + +l +++ l+++++ l++l+f+ + v++ +++ TRYP10.0.0 97 YLFVFSMMLSGRVDECALMWVNATLFTLAFVFCIVVQRQQAVDRGEIPT- 145 mklllieglglwdltlqHLaLvlvavllailvGVPL.GIlaaRprsprla + +++ gl + G+PL G+l+ sp l+ TRYP10.0.0 146 --PFTHYLMGLCRQ------------------GIPLvGVLILL--SPVLQ 173 glvfplln.vmQTiPslAlLa.lllpvfGaLg........lGirGlGlvP l+++ n+ + T+ sl +++++ll ++ L +++ ++ + +v+ TRYP10.0.0 174 TLTVAYSNdTIVTLSSLSMFVhVLLTDYNYLNcyseryqqNT-----AVN 218 AIvAlvLYalLPivRnTylGlrqVpaeviEAAraiGmtpaQrLlkVeLPL A A++ G+ + ++++Qr+++ TRYP10.0.0 219 A--ATF-------------GIILI------------ASRIQRVFQ----- 236 AlPvIlAGi...........RtalvlaigmatIAalIGAGGLGdlifrGl + +I+ Gi + ++ ++++ v + + +++++ I A + + TRYP10.0.0 237 SGALIMFGIlcftlspiprhNLKHVSLRAHVVLTFTICA------LAIYF 280 ntlntglilaGalpvalLAillDrllqllerkltpkglrrrkatkkvkvs + +l+ + v+++ +++ ++ +l + + + +++++ +k+ + TRYP10.0.0 281 LMEVPVFALLYCVVVVVISVVIPFFFVKLHGSMKDQINGPWDEAKPTNSA 330 <-* TRYP10.0.0 - - COG1455: domain 1 of 1, from 44 to 332: score -317.7, E = 34 *->MklMsaviqilEkklvPiAgKignqRhlqALRDGF.ilaMPL.iIiG +l+ q E +v q +lq LR ++++ + + +++ TRYP10.0.0 44 KVLYT--RQPYEDNYV------DPQQFLQDLRQNVnVATYEYnKVVL 82 SffLlitNLPfsfasqnfmysvflvllaewkgilg.npfnasmgIMslfv f++i + f + f +s + l++ ++ + + +na++ ++l TRYP10.0.0 83 DTFVVIQQFSFVV-FYLFVFSMM---LSGRVDECAlMWVNATL--FTLAF 126 vfGIgYnLAksYkvdAlsaGlLSlaaFlllTpysDWvPftvdgesvaamt vf I vd+ + T Pft +++ TRYP10.0.0 127 VFCIVVQ--RQQAVDRGE----------IPT------PFTHY--LMGLCR 156 GgvIPvdDaRlLGakGiFtAmiiaifsvEiYrfivqkPNlvIKmPdsVPP +IP+ +++i TRYP10.0.0 157 Q-GIPLV------------GVLI--------------------------- 166 AVskSFeALIPafiillVvllinlivqatfgtllhdiimsllqtPLaslg +L P++ +l+V+++ iv+ L+sl+ TRYP10.0.0 167 -------LLSPVLQTLTVAYSNDTIVT------------------LSSLS 191 sslggtLiavfvvqLLWFfGiHGaniitALDngvlaPIwlenidtYqqYa + + +l+ + n TRYP10.0.0 192 MFVH----------------------V------LLTDYNYLNCY------ 207 NieAflaGeplPhIftkpFldiFTVfiGGSGATLaLvlaillfskskqlK ++++ ++ V+ AT+++ il++s+ + TRYP10.0.0 208 SERYQQNT---------------AVNA----ATFGI---ILIASRIQRVF 235 qvGkLslpPGlFNINEPIiFGlPIVMNPiLfiPFvLaPminvtvtYiams q G L I+FG ++ F L+P+ + + TRYP10.0.0 236 QSGAL------------IMFG---------ILCFTLSPIPRHNLKHVSLR 264 sGlVapPvgvaVPWTmPafinAflaTggsvagllLqLvNLiisfliYLPF + V +T ++ ++ v +ll +v +is++i + F TRYP10.0.0 265 AHVVLT-------FTI-CALAIYFLMEVPVFALLYCVVVVVISVVIPFFF 306 vkaldkqklaqEkeveseetaAqagdk<-* vk k ++ + e ++ ++ TRYP10.0.0 307 VKLHGSMKDQINGPWD-EAKPTNSAAA 332 COG2311: domain 1 of 1, from 64 to 333: score -271.9, E = 28 *->tTLslvmivaktpklqPvaenERihlLDiLRGfALLGILlvNmrlFa L va+ v+ + +v ++ F+ TRYP10.0.0 64 QDLRQNVNVATYEYNKVVLD-----------------TFVV-IQQFS 92 ypglYLsllylettgyeswsaglDdvadaLidlfaqgKFitLFsfLFGvG ++ + ++ ++s+ +D a ++++ tLF++ F + TRYP10.0.0 93 FV------VFYLFVFSMMLSGRVDECA----LMWVNA---TLFTLAFVFC 129 mavmyrRalekgrrpvalyaRRlliLLllGliHatfiWdGDILllYAllg +v +++a ++g+ p ++ + Y l+g TRYP10.0.0 130 IVVQRQQAVDRGEIPTPF-------------------------THY-LMG 153 liLllfvkrkpktLLiwavaLllvplllvSlflLgaliaalgenaSmvaw l +++++++v++ll p+l +l +a ++++ + TRYP10.0.0 154 LC--------RQGIPLVGVLILLSPVLQ---TLTVAYSNDTIV------- 185 teavgaenAsfieqtiavYgsGtyleilsqRlhdrlvtmslngmifnipw + ++ + +v+ l+d +++ln + + TRYP10.0.0 186 ----T-----LSSLSMFVHV----------LLTD---YNYLNCYSERYQQ 213 ilfgisPYFSMFLLGaafaragwlknpeshkGrifrrLlaigtiAlliGl +++ + +a g++ + + + r+ g TRYP10.0.0 214 NTA------------VNAATFGIILIASRIQ-----RVFQSG-------- 238 tlnlLlvlllsqldlalrllallvlrPRllGgpflalgYLittiayLfak +l+ ++l ++ +++ + l lr + +++ + i +a f TRYP10.0.0 239 ALIMFGILCFTLSPIPRHNLKHVSLR-----AHVVLTFT-ICALAIYFLM 282 tlrrakllrpfaaVGRmALTNYLLQSlVcTtiFYgYGLGLfGrvgrlagl +++ ++ +V +++++ TRYP10.0.0 283 E---VPVFALLYCV-------------------------------VVVVI 298 liaiavfalQialStlWLrrFRyGPmEWlWRslTYlkrpGPsiPlrskks +i++f++ + +S + +++ + P s+ + TRYP10.0.0 299 SVVIPFFFVKLHGSM---------------KDQINGPWD-EAKPTNSAAA 332 s<-* + TRYP10.0.0 333 V 333 COG0395: domain 1 of 1, from 152 to 339: score -199.8, E = 29 *->rkillylfLilfaliilfPflwlvltSfkpdgntdsselfsgpptlf ++ ++ ++ +li l P+l +++++ ++ d + s+ + TRYP10.0.0 152 MGLCRQGIPLVGVLILLSPVLQTLTVAYSN----DTIVTLSSLSMFV 194 PstftlenyfrnYrkvfklttggnfpflraflNSlivalvttvlsvllss + t n Y + ++ r+ N+ + a +t++ +l++s TRYP10.0.0 195 HVLLTDYN----YLNCY--SE-------RYQQNTAVNA--ATFGIILIAS 229 lAAYAlaRlrFkGrkllfllilatlMiPfqvlliPlYllirkLGLlnplG + R F l+++ il+++ P +L + TRYP10.0.0 230 R----IQR-VFQSGALIMFGILCFTLSPIP---------RHNLKHVS--- 262 vlldTywGLILpyaagglpfnifllrqfFdtIPkELeEAAriDGAspfqi + ++L +++ +++i++l TRYP10.0.0 263 ----LRAHVVLTFTIC--ALAIYFLMEVP--------------------- 285 FfrIvLPLskPglAtvaiftFigsWNdFlwpliflsdpndslnyplyTLp + + ++ + + + p++f + + + TRYP10.0.0 286 -------------VFALLYCVVVVVISVVIPFFFVKLHG------SMKDQ 316 vgLanlingeygtdlvtapewglimAaavlaaLPililFlffQkyfvkGl + g + Aaav TRYP10.0.0 317 IN------GPWDEA------KPTNSAAAV--------------------- 333 taGgvKG<-* ++ G TRYP10.0.0 334 -EWANAG 339 COG1914: domain 1 of 1, from 1 to 342: score -332.1, E = 54 *->mrsieeeviewsdkkdstvdievemsardptspssrspkvgealskv mr+ + + ++ + ++ ++++ + + +g+ k TRYP10.0.0 1 MRNCQ--PASLRETSAMGEAAQPRGTIGSVSTETATVRDEGRVWRK- 44 avqsmirtlrkllaFlGPGlmvsvAYmDPGNyATnvqaGAqfGYqLLfvI v ++++ Y+DP TRYP10.0.0 45 -VLYTRQPYE-------------DNYVDP--------------------- 59 llsNlmAmllQnLsAkLGiaTGkdLaEacReryprplnwflwlqaElaiI +lQ L + aT e+ + l f+ +q + ++ TRYP10.0.0 60 ------QQFLQDLRQNVNVAT--------YEYNKVVLDTFVVIQQFSFVV 95 ATDLAEviGaAIaLnLLfglPliwGvviTavdvlliLalqkPngSrRgyR ++L ++++G v d +++ TRYP10.0.0 96 -------------FYLFVFSMMLSGRV----DECALMWVN---------- 118 pLEavvlaLllvivicFvvelvlarpsdlaevlkGlfvPspqtladqqal +++ l v c+vv+ + ++v +G +P+p t TRYP10.0.0 119 -----ATLFTLAFVFCIVVQ------R-QQAVDRG-EIPTPFTHY---LM 152 yLA...igIlGATVMPHsiYLhSGsLvQtRlqgydpkagnYlvdeedMee +L +++i ++G ++ L S + Qt + y+ TRYP10.0.0 153 GLCrqgIPLVG------VLILLS-PVLQTLTVAYSN-------------- 181 kkvNyRPstaarrkilrftvvdviiAlltlAgfVNaAiLivAAatfhgsg + v+ ++++++ + + ++ + ++ ++++ TRYP10.0.0 182 ----------------DTIVTLSSLSMF-VHVLLTDYNYLNCYSERYQQN 214 hgaevadLfsaYqlLapllsspaAavlFalALLasGlsstvVgTlAGDLa a a+ f + +++ + +++l++++ L+ Tl+ TRYP10.0.0 215 T-AVNAATFGIILIASRIQRVFQSGALIMFGILC--------FTLSP--- 252 qvvMeGFLrwkippwvRRliTRgiaiiPalivvllaGedptsrlLvlSQV ++ L+ ++++++ ++T i al++ l+ + + + l V TRYP10.0.0 253 --IPRHNLK-HVSLRAHVVLT---FTICALAIYFLMEVPVFALLYCVVVV 296 vLSfglPfaliPLlrFTsdrklMGalvtedkevedsadkkavaDrtadev v S+++Pf+ F++ M++++ TRYP10.0.0 297 VISVVIPFF------FVKLHGSMKDQI----------------------- 317 ieidsSSgenlnskdskivdmaNgrwvtvlaWiiallIsaLNvyLlvdtm n g w + a+ ++ +N ++m TRYP10.0.0 318 ---------N-------------GPWDEAKPTNSAAAVEWAN-----AGM 340 fG<-* + TRYP10.0.0 341 LQ 342 // hmmpfam - search a single seq against HMM database HMMER 2.1.1 (Dec 1998) Copyright (C) 1992-1998 Washington University School of Medicine HMMER is freely distributed under the GNU General Public License (GPL). - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /data/patterns/cogs/cogs.hmm-f Sequence file: TRYP10.0.001875_6.fa - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: TRYP10.0.001875_6 Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- COG1183 4.4 2.7 1 COG1988 3.4 9.7 1 COG0636 2.9 20 1 COG2851 1.4 19 1 COG0810 0.0 36 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- COG2851 1/1 231 248 .. 76 93 .. 1.4 19 COG1988 1/1 262 280 .. 1 23 [. 3.4 9.7 COG0636 1/1 285 301 .. 1 17 [. 2.9 20 COG0810 1/1 295 311 .. 287 306 .] 0.0 36 COG1183 1/1 251 316 .. 231 308 .] 4.4 2.7 Alignments of top-scoring domains: COG2851: domain 1 of 1, from 231 to 248: score 1.4, E = 19 *->iksVaptaiMlmFAILYF<-* i++V ++++++mF IL F TRYP10.0.0 231 IQRVFQSGALIMFGILCF 248 COG1988: domain 1 of 1, from 262 to 280: score 3.4, E = 9.7 *->mMtyetHvllgiafalfpliafL<-* +++ Hv+l+++ +++l++++ TRYP10.0.0 262 --SLRAHVVLTFT--ICALAIYF 280 COG0636: domain 1 of 1, from 285 to 301: score 2.9, E = 20 *->ivfgaiGaAlAlgLagl<-* +vf++++++++++++++ TRYP10.0.0 285 PVFALLYCVVVVVISVV 301 COG0810: domain 1 of 1, from 295 to 311: score 0.0, E = 36 *->pikiriripiefnlriaLek<-* +++i+++ip+ f + L++ TRYP10.0.0 295 VVVISVVIPFFFVK---LHG 311 COG1183: domain 1 of 1, from 251 to 316: score 4.4, E = 2.7 *->SnIrypsfkklsasankstiEniSavsaLlvflaliaiilalvilqp S I+ +++k++s++a +++ + ++a+++ +++ +p TRYP10.0.0 251 SPIPRHNLKHVSLRAH------------VVLTFTICALAIYFLMEVP 285 sfvllilalsyllsgpivylrriikrkrkqs<-* f+ll ++ +++s++i +++ + k+ TRYP10.0.0 286 VFALLYCVVVVVISVVIPFFFVKLHGSMKDQ 316 //