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GPI Anchor Biosynthesis Report: AAF47795.1 (PIG-B family, Drosophila melanogaster)




BLASTP 2.1.1 [Aug-8-2000]

Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query=
         (512 letters)

Database: nr
           887,402 sequences; 277,845,442 total letters

Searching..................................................

Converged !!!


Results of PSI-Blast iteration 2

Distribution of 52 Blast Hits on the Query Sequence


Sequences with E-value BETTER than threshold (0.002)

gb|AAF47795.1| (AE003479) CG12006 gene product [Drosophila melan... 658 0.0
ref|NP_061377.1| (NM_018889) phosphatidylinositol glycan, class ... 512 e-144
gb|AAH17711.1|AAH17711 (BC017711) phosphatidylinositol glycan, c... 507 e-142
ref|NP_004846.1| (NM_004855) phosphatidylinositol glycan, class ... 503 e-141
ref|NP_568305.1| (NM_121489) dolichyl-phosphate-mannose--glycoli... 493 e-138
pir||T51430 dolichyl-phosphate-mannose--glycolipid alpha-mannosy... 469 e-131
dbj|BAB32949.1| (AP002908) putative glycolipid alpha-mannosyltra... 395 e-109
pir||T41079 probable alpha 1,2 mannosyltransferase - fission yea... 376 e-103
ref|NP_011373.1| (NC_001139) Involved in glycosyl phosphatidyl i... 320 6e-86
gb|AAF54441.1| (AE003684) CG8412 gene product [Drosophila melano... 309 9e-83
emb|CAD22101.1| (AJ429133) putative mannosyltransferase [Mus mus... 300 4e-80
gb|AAH21791.1|AAH21791 (BC021791) Similar to disrupted in bipola... 286 6e-76
emb|CAB66861.1| (AL136927) hypothetical protein [Homo sapiens] 285 9e-76
gb|AAH09255.1|AAH09255 (BC009255) hypothetical protein FLJ21845 ... 284 3e-75
gb|AAL25798.1| (AF395532) DIBD1 [Homo sapiens] 283 4e-75
ref|NP_079016.1| (NM_024740) disrupted in bipolar disorder 1; si... 283 8e-75
ref|NP_077010.1| (NM_024105) hypothetical protein MGC3136 [Homo ... 274 4e-72
emb|CAC83681.1| (AJ290427) putative dolichyl-p-man: Man7GlcNAc2-... 273 6e-72
ref|NP_505071.1| (NM_072670) ZC513.5.p [Caenorhabditis elegans] ... 269 6e-71
dbj|BAA94863.1| (AB033824) GPI anchor biosynthesis protein [Tryp... 261 3e-68
ref|XP_081472.1| (XM_081472) CG11851 [Drosophila melanogaster] >... 259 7e-68
pir||T50116 probable mannosyltransferase involved in N-glycosyla... 251 2e-65
pir||T39659 cell wall biosynthesis protein N3265 homolog - fissi... 250 4e-65
pir||T28996 hypothetical protein ZC513.5 - Caenorhabditis elegans 247 3e-64
sp|Q09837|YADC_SCHPO HYPOTHETICAL 62.2 KD PROTEIN C4G8.12C IN CH... 241 2e-62
emb|CAA41123.1| (X58121) SMP3 protein [Saccharomyces cerevisiae] 240 3e-62
ref|NP_014792.1| (NC_001147) Involved in glycosyl phosphatidyl i... 238 2e-61
ref|NP_014427.1| (NC_001146) ExtraCellular Mutant; Ecm39p [Sacch... 230 4e-59
ref|NP_173134.1| (NM_101551) Ser/Thr protein kinase, putative [A... 228 3e-58
ref|NP_496282.1| (NM_063881) C14A4.3.p [Caenorhabditis elegans] ... 225 1e-57
gb|AAF99843.1|AC051629_10 (AC051629) Hypothetical protein [Arabi... 216 9e-55
emb|CAA42931.1| (X60381) ORF2 [Saccharomyces cerevisiae] 215 1e-54
ref|NP_014180.1| (NC_001146) catalyzes the transfer of mannose f... 214 4e-54
ref|NP_079439.1| (NM_025163) hypothetical protein FLJ12768 [Homo... 210 4e-53
gb|AAD53921.1|AF179611_5 (AF179611) phosphatidylinositol glycan ... 177 6e-43
ref|XP_016392.3| (XM_016392) hypothetical protein FLJ12768 [Homo... 171 3e-41
pir||T16945 hypothetical protein T27F7.3 - Caenorhabditis elegans 149 2e-34
dbj|BAA87150.1| (AB027846) Hypothetical protein [Schizosaccharom... 149 2e-34
gb|AAH21379.1|AAH21379 (BC021379) Similar to hypothetical protei... 147 4e-34
ref|NP_494918.1| (NM_062517) T27F7.3a.p [Caenorhabditis elegans]... 142 2e-32
gb|AAF47201.1| (AE003464) CG3419 gene product [Drosophila melano... 128 2e-28
dbj|BAB21931.1| (AB055306) hypothetical protein [Macaca fascicul... 102 2e-20
emb|CAC02000.2| (AL390114) possible hypothetical 66.3 Kd protein... 84 8e-15
Alignments
>gb|AAF47795.1| (AE003479) CG12006 gene product [Drosophila melanogaster]
          Length = 512

 Score =  658 bits (1681), Expect = 0.0
 Identities = 512/512 (100%), Positives = 512/512 (100%)

Query: 1   MKLIYVFLLILAVRLASVFVVQTYYVPDEYWQSLEVAHKLTFGYGYLTWEWVQGIRSYVY 60
           MKLIYVFLLILAVRLASVFVVQTYYVPDEYWQSLEVAHKLTFGYGYLTWEWVQGIRSYVY
Sbjct: 1   MKLIYVFLLILAVRLASVFVVQTYYVPDEYWQSLEVAHKLTFGYGYLTWEWVQGIRSYVY 60

Query: 61  PLLIAGLYKILALLQLDSAHLLVVLPRIRKWALFLILVPWFWFYTGSRTLANTLEASLTT 120
           PLLIAGLYKILALLQLDSAHLLVVLPRIRKWALFLILVPWFWFYTGSRTLANTLEASLTT
Sbjct: 61  PLLIAGLYKILALLQLDSAHLLVVLPRIRKWALFLILVPWFWFYTGSRTLANTLEASLTT 120

Query: 121 IALSYFPWYGESTAYLWPAAICCFLRPTAAVIWLPLSLYHLRRSRQNVLELILKRFVLIG 180
           IALSYFPWYGESTAYLWPAAICCFLRPTAAVIWLPLSLYHLRRSRQNVLELILKRFVLIG
Sbjct: 121 IALSYFPWYGESTAYLWPAAICCFLRPTAAVIWLPLSLYHLRRSRQNVLELILKRFVLIG 180

Query: 181 LLVAGLGIAIDTYWHGQLIVTPYEFLKYNIFNNIGSFYGSHPWHWYFSVGLPTVLGINTL 240
           LLVAGLGIAIDTYWHGQLIVTPYEFLKYNIFNNIGSFYGSHPWHWYFSVGLPTVLGINTL
Sbjct: 181 LLVAGLGIAIDTYWHGQLIVTPYEFLKYNIFNNIGSFYGSHPWHWYFSVGLPTVLGINTL 240

Query: 241 PFIFGVMETVKKSEKYPVSKQLLITIFLTLVVLSAVEHKEFRFVSPLLPLCLYVITDALS 300
           PFIFGVMETVKKSEKYPVSKQLLITIFLTLVVLSAVEHKEFRFVSPLLPLCLYVITDALS
Sbjct: 241 PFIFGVMETVKKSEKYPVSKQLLITIFLTLVVLSAVEHKEFRFVSPLLPLCLYVITDALS 300

Query: 301 RWSIRASSTMLWTTALVILVGNVMPAWYLSTVHQKGPIELMPKLREIAREYRDEREHQAN 360
           RWSIRASSTMLWTTALVILVGNVMPAWYLSTVHQKGPIELMPKLREIAREYRDEREHQAN
Sbjct: 301 RWSIRASSTMLWTTALVILVGNVMPAWYLSTVHQKGPIELMPKLREIAREYRDEREHQAN 360

Query: 361 ILFLMPCHSTPYYSHIHQNVTMRFLTCEPNLEKKEQYKDEADRFFEDPVHWINSHIPMHP 420
           ILFLMPCHSTPYYSHIHQNVTMRFLTCEPNLEKKEQYKDEADRFFEDPVHWINSHIPMHP
Sbjct: 361 ILFLMPCHSTPYYSHIHQNVTMRFLTCEPNLEKKEQYKDEADRFFEDPVHWINSHIPMHP 420

Query: 421 LTALPTHVVLFDPLAENISVFLRNYRLLHRIEHAENRQSRTGRSILVYQRLKKGEENAFN 480
           LTALPTHVVLFDPLAENISVFLRNYRLLHRIEHAENRQSRTGRSILVYQRLKKGEENAFN
Sbjct: 421 LTALPTHVVLFDPLAENISVFLRNYRLLHRIEHAENRQSRTGRSILVYQRLKKGEENAFN 480

Query: 481 RGPDSGQHEPDVHDHPPLEDLVLANENENLFN 512
           RGPDSGQHEPDVHDHPPLEDLVLANENENLFN
Sbjct: 481 RGPDSGQHEPDVHDHPPLEDLVLANENENLFN 512
>ref|NP_061377.1| (NM_018889) phosphatidylinositol glycan, class B; involved in
           GPI-anchor biosynthesis [Mus musculus]
 dbj|BAA94827.1| (D84436) Pig-b [Mus musculus]
          Length = 542

 Score =  512 bits (1307), Expect = e-144
 Identities = 194/504 (38%), Positives = 277/504 (54%), Gaps = 47/504 (9%)

Query: 5   YVFLLILAVRLASVFVVQTYYVPDEYWQSLEVAHKLTFGYGYLTWEWVQGIRSYVYPLLI 64
           Y+ L  +A+R+ + F+VQT +VPDEYWQSLEVAH++ F YGYLTWEW + +R Y YPL+ 
Sbjct: 51  YLVLFTIALRILNCFLVQTSFVPDEYWQSLEVAHRMVFSYGYLTWEWTERLRGYTYPLIF 110

Query: 65  AGLYKILALLQLDSAHLLVVLPRI-------------------------RKWALFLILVP 99
           A +YK+L LL  DS   L+ +PR+                          +W     L  
Sbjct: 111 ASIYKVLHLLGKDSVQFLIWIPRLGQALLSAVADIRLYSLLKQLENQEVAQWVFLCQLCS 170

Query: 100 WFWFYTGSRTLANTLEASLTTIALSYFPWYG----ESTAYLWPAAICCFLRPTAAVIWLP 155
           WF +Y  +RTL NT+E SLT +AL Y+P  G     S  Y    A+ C +RPTA + W+P
Sbjct: 171 WFTWYCCTRTLTNTMETSLTALALFYYPLEGSRSVNSIKYSLLVALACVVRPTALIPWVP 230

Query: 156 LSLYHLRRSRQNVLELILKRFVLIGLLVAGLGIAIDTYWHGQLIVTPYEFLKYNIFNNIG 215
           L   H  + ++  L L L  F+ +G +   L + ID  + GQ  +    FLK+N+  N+G
Sbjct: 231 LLFRHFYQEQR-KLHLTLHHFLPVGFITFSLSLIIDRIFFGQWTLVQLNFLKFNVLQNLG 289

Query: 216 SFYGSHPWHWYFSVGLPTVLGINTLPFIFGVMETVKKSEKYPVSKQLLITIFLTLVVLSA 275
           +FYGSHPWHWY S G P VLG +   FI G     ++         LL+T+  TL+V S 
Sbjct: 290 TFYGSHPWHWYLSQGFPVVLGTHLPFFIHGCFLAPRRLHI------LLLTVLWTLLVYSM 343

Query: 276 VEHKEFRFVSPLLPLCLYVITDALSRWSIRASSTMLWTTALVILVGNVMPAWYLSTVHQK 335
           + HKEFRF+ P+LP C+     +L+       + +       +L+ NV  A+Y   VHQ+
Sbjct: 344 LGHKEFRFIYPVLPFCMVFCGYSLAHLKTWRKAALS-----FLLLSNVPLAFYTGLVHQR 398

Query: 336 GPIELMPKLREIAREYRDEREHQANILFLMPCHSTPYYSHIHQNVTMRFLTCEPNLEKKE 395
           G +++M  ++++    R      A++  +MPCHSTPYYSH+H  ++MRFL C P+L  K 
Sbjct: 399 GTLDVMNHIQKVCP--RGPDPASASVFIMMPCHSTPYYSHVHCPLSMRFLQCPPDLTGKT 456

Query: 396 QYKDEADRFFEDPVHWINSHIPMHPLTALPTHVVLFDPLAENISVFLR--NYRLLHRIEH 453
           QY DEAD F+ +P+ W+      H   +LPTH+V F+ L + I+ FL   NY       H
Sbjct: 457 QYLDEADMFYLNPLRWLQQ--EFHSNASLPTHLVTFNVLEKEINTFLTSGNYERAATFFH 514

Query: 454 AENRQSRTGRSILVYQRLKKGEEN 477
               + RTG  I VY+R   G  N
Sbjct: 515 THWPERRTGSHIHVYERRLPGRVN 538
>gb|AAH17711.1|AAH17711 (BC017711) phosphatidylinositol glycan, class B [Homo sapiens]
          Length = 554

 Score =  507 bits (1294), Expect = e-142
 Identities = 201/505 (39%), Positives = 280/505 (54%), Gaps = 47/505 (9%)

Query: 4   IYVFLLILAVRLASVFVVQTYYVPDEYWQSLEVAHKLTFGYGYLTWEWVQGIRSYVYPLL 63
           IY+ L  LA+R+ + F+VQT +VPDEYWQSLEV+H + F YGYLTWEW + +RSY YPL+
Sbjct: 61  IYLLLFTLALRILNCFLVQTSFVPDEYWQSLEVSHHMVFNYGYLTWEWTERLRSYTYPLI 120

Query: 64  IAGLYKILALLQLDSAHLLVVLPRIRK-------------------------WALFLILV 98
            A +YKIL LL  DS  LL+ +PR+ +                         W  F  L 
Sbjct: 121 FASIYKILHLLGKDSVQLLIWIPRLAQALLSAVADVRLYSLMKQLENQEVARWVFFCQLC 180

Query: 99  PWFWFYTGSRTLANTLEASLTTIALSYFPWYG----ESTAYLWPAAICCFLRPTAAVIWL 154
            WF +Y  +RTL NT+E  LT IAL Y+P  G     S  Y    A+   +RPTA ++W 
Sbjct: 181 SWFTWYCCTRTLTNTMETVLTIIALFYYPLEGSKSMNSVKYSSLVALAFIIRPTAVILWT 240

Query: 155 PLSLYHLRRSRQNVLELILKRFVLIGLLVAGLGIAIDTYWHGQLIVTPYEFLKYNIFNNI 214
           PL   H        L+LIL  F+ +G +   L + ID  + GQ  +  + FLK+N+  N+
Sbjct: 241 PLLFRHFC-QEPRKLDLILHHFLPVGFVTLSLSLMIDRIFFGQWTLVQFNFLKFNVLQNL 299

Query: 215 GSFYGSHPWHWYFSVGLPTVLGINTLPFIFGVMETVKKSEKYPVSKQLLITIFLTLVVLS 274
           G+FYGSHPWHWYFS G P +LG +   FI G     K+       + LL+T+  TL+V S
Sbjct: 300 GTFYGSHPWHWYFSQGFPVILGTHLPFFIHGCYLAPKRY------RILLVTVLWTLLVYS 353

Query: 275 AVEHKEFRFVSPLLPLCLYVITDALSRWSIRASSTMLWTTALVILVGNVMPAWYLSTVHQ 334
            + HKEFRF+ P+LP C+     +L+         +       + + N+  A Y   VHQ
Sbjct: 354 MLSHKEFRFIYPVLPFCMVFCGYSLTHLKTWKKPALS-----FLFLSNLFLALYTGLVHQ 408

Query: 335 KGPIELMPKLREIAREYRDEREHQANILFLMPCHSTPYYSHIHQNVTMRFLTCEPNLEKK 394
           +G +++M  ++++   Y +  +  A+I  +MPCHSTPYYSH+H  + MRFL C P+L  K
Sbjct: 409 RGTLDVMSHIQKVC--YNNPNKSSASIFIMMPCHSTPYYSHVHCPLPMRFLQCPPDLTGK 466

Query: 395 EQYKDEADRFFEDPVHWINSHIPMHPLTALPTHVVLFDPLAENISVFL--RNYRLLHRIE 452
             Y DEAD F+ +P++W  SH   H   +LPTH++ F  L E IS FL   NY+      
Sbjct: 467 SHYLDEADVFYLNPLNW--SHREFHDDASLPTHLITFSILEEEISAFLISSNYKRTAVFF 524

Query: 453 HAENRQSRTGRSILVYQRLKKGEEN 477
           H    + R G  I VY+R  KG+ N
Sbjct: 525 HTHLPEGRIGSHIYVYERKLKGKFN 549
>ref|NP_004846.1| (NM_004855) phosphatidylinositol glycan, class B [Homo sapiens]
 pir||S71751 dolichyl-phosphate-mannose--glycolipid alpha-mannosyltransferase
           (EC 2.4.1.130) PIGB - human
 dbj|BAA07709.1| (D42138) PIG-B [Homo sapiens]
          Length = 554

 Score =  503 bits (1284), Expect = e-141
 Identities = 199/505 (39%), Positives = 279/505 (54%), Gaps = 47/505 (9%)

Query: 4   IYVFLLILAVRLASVFVVQTYYVPDEYWQSLEVAHKLTFGYGYLTWEWVQGIRSYVYPLL 63
           IY+ L  +A+R+ + F+VQT +VPDEYWQSLEV+H + F YGYLTWEW + +RSY YPL+
Sbjct: 61  IYLLLFTIALRILNCFLVQTSFVPDEYWQSLEVSHHMVFNYGYLTWEWTERLRSYTYPLI 120

Query: 64  IAGLYKILALLQLDSAHLLVVLPRIRK-------------------------WALFLILV 98
            A +YKIL LL  DS  LL+ +PR+ +                         W  F  L 
Sbjct: 121 FASIYKILHLLGKDSVQLLIWIPRLAQALLSAVADVRLYSLMKQLENQEVARWVFFCQLC 180

Query: 99  PWFWFYTGSRTLANTLEASLTTIALSYFPWYG----ESTAYLWPAAICCFLRPTAAVIWL 154
            WF +Y  +RTL NT+E  LT IAL Y+P  G     S  Y    A+   +RPTA ++W 
Sbjct: 181 SWFTWYCCTRTLTNTMETVLTIIALFYYPLEGSKSMNSVKYSSLVALAFIIRPTAVILWT 240

Query: 155 PLSLYHLRRSRQNVLELILKRFVLIGLLVAGLGIAIDTYWHGQLIVTPYEFLKYNIFNNI 214
           PL   H        L+LIL  F+ +G +   L + ID  + GQ  +  + FLK+N+  N 
Sbjct: 241 PLLFRHFC-QEPRKLDLILHHFLPVGFVTLSLSLMIDRIFFGQWTLVQFNFLKFNVLQNW 299

Query: 215 GSFYGSHPWHWYFSVGLPTVLGINTLPFIFGVMETVKKSEKYPVSKQLLITIFLTLVVLS 274
           G+FYGSHPWHWYFS G P +LG +   FI G     K+       + LL+T+  TL+V S
Sbjct: 300 GTFYGSHPWHWYFSQGFPVILGTHLPFFIHGCYLAPKRY------RILLVTVLWTLLVYS 353

Query: 275 AVEHKEFRFVSPLLPLCLYVITDALSRWSIRASSTMLWTTALVILVGNVMPAWYLSTVHQ 334
            + HKEFRF+ P+LP C+     +L+         +       + + N+  A Y   VHQ
Sbjct: 354 MLSHKEFRFIYPVLPFCMVFCGYSLTHLKTWKKPALS-----FLFLSNLFLALYTGLVHQ 408

Query: 335 KGPIELMPKLREIAREYRDEREHQANILFLMPCHSTPYYSHIHQNVTMRFLTCEPNLEKK 394
           +G +++M  ++++   Y +  +  A+I  +MPCHSTPYYSH+H  + MRFL C P+L  K
Sbjct: 409 RGTLDVMSHIQKVC--YNNPNKSSASIFIMMPCHSTPYYSHVHCPLPMRFLQCPPDLTGK 466

Query: 395 EQYKDEADRFFEDPVHWINSHIPMHPLTALPTHVVLFDPLAENISVFL--RNYRLLHRIE 452
             Y DEAD F+ +P++W+  H   H   +LPTH++ F  L E IS FL   NY+      
Sbjct: 467 SHYLDEADVFYLNPLNWL--HREFHDDASLPTHLITFSILEEEISAFLISSNYKRTAVFF 524

Query: 453 HAENRQSRTGRSILVYQRLKKGEEN 477
           H    + R G  I VY+R  KG+ N
Sbjct: 525 HTHLPEGRIGSHIYVYERKLKGKFN 549
>ref|NP_568305.1| (NM_121489) dolichyl-phosphate-mannose--glycolipid
           alpha-mannosyltransferase -like protein [Arabidopsis
           thaliana]
 gb|AAK91470.1| (AY050456) AT5g14850/T9L3_150 [Arabidopsis thaliana]
          Length = 548

 Score =  493 bits (1257), Expect = e-138
 Identities = 175/517 (33%), Positives = 271/517 (51%), Gaps = 73/517 (14%)

Query: 6   VFLLILAVRLASVFVVQTYYVPDEYWQSLEVAHKLTFGYGYLTWEWVQGIRSYVYPLLIA 65
           +FL  LA R+ +  ++QTY+ PDE+WQSLEVAH+  FGYGY+TWEW +GIRSY++P+L A
Sbjct: 41  IFLFCLAFRVVNALLIQTYFNPDEHWQSLEVAHRTIFGYGYMTWEWKRGIRSYLHPMLFA 100

Query: 66  GLYKILALLQLDSAHLLVVLPRIRK-------------------------WALFLILVPW 100
            LYK+L +  LD+ ++++  PR+ +                         W+LF  +  W
Sbjct: 101 FLYKLLQVTGLDTPYIMIKAPRLMQSIFSAIGDLYLYKLSDALYGGNVATWSLFCQMANW 160

Query: 101 FWFYTGSRTLANTLEASLTTIALSYFPWYGESTA--------YLWPAAICCFLRPTAAVI 152
           F F+  +RT +N LE  LT + L Y+P   +S+          L  AA+ C +RPT+AVI
Sbjct: 161 FIFFCLNRTFSNCLETVLTIMGLYYWPCIRDSSIDYPVNRKWGLVIAALACAIRPTSAVI 220

Query: 153 WLPLSLYHLRRSRQNVLELILKRFVLIGLLVAGLGIAIDTYWHGQLIVTPYEFLKYNIFN 212
           WL + +  L  +  N ++ I+   + IG LV G    +D   +G  ++ P  FLK+N  +
Sbjct: 221 WLYVGMLELFLT-PNKVKFIILEVIPIGSLVLGFTCLLDRLMYGSWVIVPLNFLKFNFLS 279

Query: 213 NIGSFYGSHPWHWYFSVGLPTVLGINTLPFIFGVMETVKKSEKYPVSKQLLITIFLTLVV 272
           + G +YG+HPWHWYF+ G   +L   T   I G++           +++L   I   L +
Sbjct: 280 SGGDYYGTHPWHWYFTQGFLVMLFTFTPFSIAGII--------KSKNQKLSALILWVLAI 331

Query: 273 LSAVEHKEFRFVSPLLPLCLYVITDALSRWSIRAS--------------------STMLW 312
            S + HKEFRFV P+LP+ L     A ++  +  S                    S  L 
Sbjct: 332 YSILGHKEFRFVLPVLPIALIFSGYAFAQMEVSGSSSSSSVTKKKQVPRQNHTKWSPKLR 391

Query: 313 TTALVILVGNVMPAWYLSTVHQKGPIELMPKLREIAREYRDEREHQANILFLMPCHSTPY 372
            +   +L  N+  A Y+S  HQ+G  + M  L + A + R       +ILFLMPCHSTPY
Sbjct: 392 LSVYFLLATNIPMALYMSLFHQRGTEDAMNYLSDEAYKGR-----VKSILFLMPCHSTPY 446

Query: 373 YSHIHQNVTMRFLTCEPNLEKKEQYKDEADRFFEDPVHWINSHIPMHPLTALPTHVVLFD 432
           YS +H+N+ M+FL C P+ EK E   DE+D+F  +P+ + +        +  P+H+VLF 
Sbjct: 447 YSTLHRNIPMQFLDCTPSAEKGE--LDESDQFLVNPLGFASEL--ARNWSEPPSHIVLFA 502

Query: 433 PLAENISVFL--RNYRLLHRIEHAENRQSRTGRSILV 467
                +  F+   +++ + R  HA  +  R  +S +V
Sbjct: 503 SEETKLRDFMIQHSFKEVRRFFHAHFKVDRDLQSSVV 539
>pir||T51430 dolichyl-phosphate-mannose--glycolipid
           alpha-mannosyltransferase-like protein - Arabidopsis
           thaliana
 emb|CAC01884.1| (AL391149) dolichyl-phosphate-mannose--glycolipid
           alpha-mannosyltransferase-like protein [Arabidopsis
           thaliana]
          Length = 498

 Score =  469 bits (1196), Expect = e-131
 Identities = 164/479 (34%), Positives = 254/479 (52%), Gaps = 52/479 (10%)

Query: 6   VFLLILAVRLASVFVVQTYYVPDEYWQSLEVAHKLTFGYGYLTWEWVQGIRSYVYPLLIA 65
           +FL  LA R+ +  ++QTY+ PDE+WQSLEVAH+  FGYGY+TWEW +GIRSY++P+L A
Sbjct: 41  IFLFCLAFRVVNALLIQTYFNPDEHWQSLEVAHRTIFGYGYMTWEWKRGIRSYLHPMLFA 100

Query: 66  GLYKILALLQLDSAHLLVVLPRIRKWALFLILVPWFWFYTGSRTLAN--TLEASLTTIAL 123
            LYK+L +  LD+ ++++  PR+ +     I   + +  + +    N  T    LT + L
Sbjct: 101 FLYKLLQVTGLDTPYIMIKAPRLMQSIFSAIGDLYLYKLSDALYGGNVATWSTVLTIMGL 160

Query: 124 SYFPWYGESTA--------YLWPAAICCFLRPTAAVIWLPLSLYHLRRSRQNVLELILKR 175
            Y+P   +S+          L  AA+ C +RPT+AVIWL + +  L  +  N ++ I+  
Sbjct: 161 YYWPCIRDSSIDYPVNRKWGLVIAALACAIRPTSAVIWLYVGMLELFLT-PNKVKFIILE 219

Query: 176 FVLIGLLVAGLGIAIDTYWHGQLIVTPYEFLKYNIFNNIGSFYGSHPWHWYFSVGLPTVL 235
            + IG LV G    +D   +G  ++ P  FLK+N  ++ G +YG+HPWHWYF+ G   +L
Sbjct: 220 VIPIGSLVLGFTCLLDRLMYGSWVIVPLNFLKFNFLSSGGDYYGTHPWHWYFTQGFLVML 279

Query: 236 GINTLPFIFGVMETVKKSEKYPVSKQLLITIFLTLVVLSAVEHKEFRFVSPLLPLCLYVI 295
              T   I G++           +++L   I   L + S + HKEFRFV P+LP+ L   
Sbjct: 280 FTFTPFSIAGII--------KSKNQKLSALILWVLAIYSILGHKEFRFVLPVLPIALIFS 331

Query: 296 TDALSRWSIRAS--------------------STMLWTTALVILVGNVMPAWYLSTVHQK 335
             A ++  +  S                    S  L  +   +L  N+  A Y+S  HQ+
Sbjct: 332 GYAFAQMEVSGSSSSSSVTKKKQVPRQNHTKWSPKLRLSVYFLLATNIPMALYMSLFHQR 391

Query: 336 GPIELMPKLREIAREYRDEREHQANILFLMPCHSTPYYSHIHQNVTMRFLTCEPNLEKKE 395
           G  + M  L + A + R       +ILFLMPCHSTPYYS +H+N+ M+FL C P+ EK E
Sbjct: 392 GTEDAMNYLSDEAYKGR-----VKSILFLMPCHSTPYYSTLHRNIPMQFLDCTPSAEKGE 446

Query: 396 QYKDEADRFFEDPVHWINSHIPMHPLTALPTHVVLFDPLAENISVFLRNYRLLHRIEHA 454
              DE+D+F  +P+ + +        +  P+H+VLF          LR++ + H  + A
Sbjct: 447 --LDESDQFLVNPLGFASEL--ARNWSEPPSHIVLFASEE----TKLRDFMIQHSFKEA 497
>dbj|BAB32949.1| (AP002908) putative glycolipid alpha-mannosyltransferase [Oryza
           sativa]
 dbj|BAB84454.1| (AP003546) putative glycolipid alpha-mannosyltransferase [Oryza
           sativa]
          Length = 506

 Score =  395 bits (1006), Expect = e-109
 Identities = 158/472 (33%), Positives = 242/472 (50%), Gaps = 54/472 (11%)

Query: 6   VFLLILAVRLASVFVVQTYYVPDEYWQSLEVAHKLTFGYGYLTWEWVQGIRSYVYPLLIA 65
           V  L LA R A+  +V+TY+ PDE+WQ LEVAH++ FGYG+LTWEW +G+RSY++P + A
Sbjct: 48  VLALALAFRAANALLVRTYFNPDEHWQCLEVAHRIVFGYGHLTWEWKRGLRSYLHPFIFA 107

Query: 66  GLYKILALLQLDSAHLLVVLPRIRKWALFLILVPWFWFYTGSRTLANT----LEASLTTI 121
            LYKIL+LL LDS   + + PR+ +           + Y  S+ + N     +E  LT  
Sbjct: 108 ALYKILSLLHLDSPWFMAMAPRLLQSVFASFGD--LYLYKLSKLIFNNHVAHMETVLTVT 165

Query: 122 ALSYF-----PWYGESTAYLWPAA----------------ICCFLRPTAAVIWLPLSLYH 160
            L Y+        G S      AA                + C +RPT+A+ WL + L  
Sbjct: 166 GLYYWFVAIESVKGNSVVSKQQAASKQSPPSRKMALLIAALACAIRPTSAITWLYVGLLD 225

Query: 161 LRRSRQNVLELILKRFVLIGLLVAGLGIAIDTYWHGQLIVTPYEFLKYNIFNNIGSFYGS 220
             + +      I    V +G+ V  +   +D + +G  I+ P  FLK+N+F++ G +YG+
Sbjct: 226 FIQMKSKSR-FIFLEVVPLGVFVLAVTTFLDCWMYGSRIIVPLNFLKFNLFSSGGDYYGT 284

Query: 221 HPWHWYFSVGLPTVLGINTLPFIFGVMETVKKSEKYPVSKQLLITIFLTLVVLSAVEHKE 280
           H +HWYFS G P+++       I G++++ +          L   I   LVV S + HKE
Sbjct: 285 HVFHWYFSQGFPSMIWTFLPFSISGILKSREWR--------LAGLIVWVLVVYSILGHKE 336

Query: 281 FRFVSPLLPLCLYVITDALSRWSIRASS--------TMLWTTALVILVGNVMPAWYLSTV 332
           FRFV P+LP         L+  +             + L  + +++++ NV  A Y+S  
Sbjct: 337 FRFVLPVLPFMFMFSGHNLAAMAQLKGKGHNEKGRLSRLKLSVILLILTNVPMALYMSLY 396

Query: 333 HQKGPIELMPKLREIAREYRDEREHQANILFLMPCHSTPYYSHIHQNVTMRFLTCEPNLE 392
           HQ+G  + M  L   A + R       ++LFLMPCHSTPYYS +H N+ MRFL C P+  
Sbjct: 397 HQRGTEDAMLYLSREAHDGR-----VKSVLFLMPCHSTPYYSTLHYNLPMRFLDCTPSEN 451

Query: 393 KKEQYKDEADRFFEDPVHWINSHIPMHPLTALPTHVVLFDPLAENISVFLRN 444
           K     DE+DRF  +P  ++        L++  +H+VLF+    ++ + LRN
Sbjct: 452 KGT--LDESDRFLMNPADFVGE--VFGNLSSF-SHIVLFESEERHVKLLLRN 498
>pir||T41079 probable alpha 1,2 mannosyltransferase - fission yeast
           (Schizosaccharomyces pombe)
 emb|CAB53078.1| (AL109957) putative alpha 1,2 mannosyltransferase
           [Schizosaccharomyces pombe]
          Length = 506

 Score =  376 bits (956), Expect = e-103
 Identities = 144/536 (26%), Positives = 239/536 (43%), Gaps = 100/536 (18%)

Query: 4   IYVFLLILAVRLASVFVVQTYYVPDEYWQSLEVAHKLTFGYGYLTWEWVQGIRSYVYPLL 63
           I+ +L IL  R  +   V+T++ PDE++QSLEVAH   F YG+LTWEW   IRS ++PL+
Sbjct: 3   IWFWLAILVFRWWNALWVKTFFQPDEFYQSLEVAHHFIFRYGFLTWEWTSAIRSALHPLI 62

Query: 64  IAGLYKILALLQLDSAHLLV--------------------------VLPRIRKWALFLIL 97
            A LY++L +L+LDS++ +                              +   W L   L
Sbjct: 63  FAALYRVLQVLKLDSSYFVFTNAPKLLQGTFAAILDYGTYKFALVRYGSKTANWTLACSL 122

Query: 98  VPWFWFYTGSRTLANTLEASLTTIALSYFPWYGES---------------TAYLWPAAIC 142
           V     Y G RT +N+LE +LT+I   YF +Y +                  ++  AA  
Sbjct: 123 VSIMNAYVGVRTFSNSLETTLTSIGFYYFSYYLKYENSSPEQRKKAYSSLLGFISVAAFA 182

Query: 143 CFLRPTAAVIWLPLSLYHLRRSRQNVLEL-----ILKRFVLIGLLVAG------------ 185
           CF+RPT  ++W+   L+  +  +  + +L     +  RF  +  L  G            
Sbjct: 183 CFIRPTNILVWIFPLLFWNKNPQTPIKDLLSFSNVFNRFRFLYALGYGRLFGIFVLCVSL 242

Query: 186 --LGIAIDTYWHGQLIVTPYEFLKYNIFNNIGSFYGSHPWHWYFSVGLPTVLGINTLPFI 243
             + I  D   +G+ +     F ++N+ + + S YG + WH+Y S  LP + G      +
Sbjct: 243 FLVNIIADRILYGRFVFPIISFFQFNVTSGLSSLYGLNAWHYYLSQALPLICGGFLPFVL 302

Query: 244 FGVMETVKKSEKYPVSKQLLITIFLTLVVLSAVEHKEFRFVSPLLPLCLYVITDALSRWS 303
             +              Q   TI       S + HKE RFV P+ P+ L +     S +S
Sbjct: 303 LTMD------------LQTAGTILCVFFPYSLIGHKELRFVYPISPILLTLAGKFFSSFS 350

Query: 304 IRASSTMLWTTALVILVGNVMPAWYLSTVHQKGPIELMPKLREIAREYRDEREHQANILF 363
               +        +I +G+ +   +L   HQ G +E+MP +  +A +           L 
Sbjct: 351 SWKRAARF---FFLIGLGHALVITFLCRFHQFGVMEVMPLIHSLAEKN-------QTGLI 400

Query: 364 LMPCHSTPYYSHIHQNVT---MRFLTCEPNLEKKEQYKDEADRFFEDPVHWINSHIPMHP 420
           L PCH+TP+ SHIH        +FLTCEP     E+  DE DRF+E+   +++       
Sbjct: 401 LAPCHTTPWQSHIHSPFAENGWKFLTCEPF----EKPFDETDRFYENMPTFLDK------ 450

Query: 421 LTALPTHVVLFDPLAENISVFLRN----YRLLHRIEHAENRQSRT-GRSILVYQRL 471
           +   P +++ F+    ++  +L +    Y  + R  ++   +SR    ++LVY++L
Sbjct: 451 IKEWPDYLIFFEERFYSLYSYLDSRGLKYEEVQRYYNSLIPESRERAGALLVYKKL 506
>ref|NP_011373.1| (NC_001139) Involved in glycosyl phosphatidyl inositol synthesis;
           could be the target of the GPI synthesis inhibitor,
           YW3548; Most likely an alpha 1,2 mannosyltransferase
           utilized for the addition of the third mannose onto the
           GPI core structure.; Gpi1>
 sp|P30777|YGO2_YEAST Hypothetical 72.6 kDa protein in MRF1-HUL5 intergenic region
 pir||S64156 probable membrane protein YGL142c - yeast (Saccharomyces
           cerevisiae)
 emb|CAA96854.1| (Z72664) ORF YGL142c [Saccharomyces cerevisiae]
 emb|CAA68220.1| (X99960) putative, YGL142c [Saccharomyces cerevisiae]
          Length = 616

 Score =  320 bits (812), Expect = 6e-86
 Identities = 139/531 (26%), Positives = 230/531 (43%), Gaps = 76/531 (14%)

Query: 2   KLIYVFLLILAVRLASVFVVQTYYVPDEYWQSLEVAHKLTFGYGYLTWEWVQGIRSYVYP 61
            ++  + L+L   + S  ++       +Y  S +VA  L      +T  +      Y   
Sbjct: 86  SILLHYALLLLSTIGSDLLILLL---PKYELSWQVAEDLKRLPFDVTRSFEYYGVIYAPK 142

Query: 62  LLIAGLYKI-----------LALLQLDSAHLLVV------LPRIRKWALFLILVPWFWFY 104
           +++A L  I           L LL LD  +          L  I K+AL L L  +F  +
Sbjct: 143 IVMAVLASIGEYYIVRFVQKLYLLTLDKRNEKEEEERRSGLSEITKFALLLSLTNFFNCF 202

Query: 105 TGSRTLANTLEASLTTIALSYFPWYG-------ESTAYLWPAAICCFLRPTAAVIW---- 153
             +RT  N+ E  LT+IAL Y+ W G         T  L  A + C  RP++ +IW    
Sbjct: 203 FITRTFINSFEMILTSIALYYWDWTGGQMIKESSFTKSLIFAFLACLQRPSSGLIWVIPS 262

Query: 154 LPLSLYHLRRSRQNVLELILKRFVLIGLLVAGLGIAIDTYWHGQLIVTPYEFLKYNIFNN 213
           + L L  + + + ++L +   + +    LV      ID Y++ ++    + FLK+N    
Sbjct: 263 ISLILNLVGKKQYHLLFITFSKVLRSFFLVFTANAIIDMYFYEKVTFPFFRFLKFNFTTP 322

Query: 214 IGSFYGSHPWHWYFSVGLPTVLGINTLPFIFGVMETVKKSEK----YPVSKQLLITIFLT 269
           +  FYG  PWH++F   LP VLG +   F FG+   + K            Q+ +TI L 
Sbjct: 323 LSKFYGVAPWHFHFFQSLPIVLGASIPAFAFGLFFPLSKRSFPKKYLNPFFQVKLTILLN 382

Query: 270 LVVLSAVEHKEFRFVSPLLPLCLYVITDALSRW--SIRASSTMLWTTALVILVGNVMPAW 327
           L+V S + HKEFRF+ PL PL + + +  L R         + L +   ++   +V  A 
Sbjct: 383 LLVYSTLPHKEFRFIFPLQPLFILISSFGLLRLDRDYWKRLSGLKSLLWLVPFVSVFIAL 442

Query: 328 YLSTVHQKGPIELMPKLREIAREYRDEREHQANILFLMPCHSTPYYSHIHQNVTMRF--L 385
            L T H+ G IE+M        ++  E     ++ F+MPCHSTP  S++H++       +
Sbjct: 443 LLDTFHESGSIEVM--------KFLHEEPEIDSLGFIMPCHSTPGQSYLHRSDIQDLWSI 494

Query: 386 TCEPNLE---------KKEQYKDEADRFFEDPVHWINSHIPMHPLT-----------ALP 425
           TC P L          K E Y DE+D  ++D   +I  + P                  P
Sbjct: 495 TCNPPLHLLGDPEAYSKLETYMDESDHLYDDISAFIYKNFPPPFRKDLRSPGKTYSHEWP 554

Query: 426 THVVLFDPLAENI-------SVFLRNYRLLHRIEHAENRQSRTGRSILVYQ 469
           T++V+F+ +           S ++   R  + + H ++R  R+G  I+ Y+
Sbjct: 555 TYLVVFEHMENAFLKDFLKDSSYIEYNRFFNSLAHWDSR--RSGDIIIYYK 603
 Score = 80.9 bits (198), Expect = 4e-14
 Identities = 28/68 (41%), Positives = 47/68 (68%)

Query: 6  VFLLILAVRLASVFVVQTYYVPDEYWQSLEVAHKLTFGYGYLTWEWVQGIRSYVYPLLIA 65
          +F + LA R+ +  + +T++  DE+WQ+LE AH   F YG LTWEW  G+RSY++P++  
Sbjct: 17 IFWVFLAFRVLNAVLTRTFFQADEFWQALEPAHWKAFKYGELTWEWKFGVRSYLFPMIFE 76

Query: 66 GLYKILAL 73
            Y++++L
Sbjct: 77 LTYRLVSL 84
>gb|AAF54441.1| (AE003684) CG8412 gene product [Drosophila melanogaster]
 gb|AAL48754.1| (AY071132) RE17513p [Drosophila melanogaster]
          Length = 678

 Score =  309 bits (784), Expect = 9e-83
 Identities = 75/416 (18%), Positives = 157/416 (37%), Gaps = 60/416 (14%)

Query: 10  ILAVRLASVFVVQTYYVPDEYWQSLEVAHKLTF------GYGYLTWEWVQGIRSYVYPLL 63
           IL    A+  +V T +   E   +L+  H + +       Y +  +  V   R+++ PL+
Sbjct: 3   ILIFVTAAAHLVYTPFTKVEESFNLQAMHDILYLRNNFTQYDHHDYPGVVP-RTFIGPLV 61

Query: 64  IAGL-------------------YKIL---------ALLQLDSAHLLVVLPRIRKWALFL 95
           ++ +                   Y +          A   L  A   +    +R W   +
Sbjct: 62  VSIISAPFVLLFETLSINKFWAQYVVRLVLAGAISVAWNSLRQAVTKIYGVEVRLWFTAI 121

Query: 96  ILVPWFWFYTGSRTLANTLEASLTTIALSYFPWYGESTAYLWPAAICCFLRPTAAVIWLP 155
            +  + + +  +R L N     +   A++Y+    +   ++  + I   +  +   ++L 
Sbjct: 122 TITQFHFMFYMTRPLPNIFALPIVLFAIAYWLR-DQHKPFIICSGISILVFRSELALFLG 180

Query: 156 LSLYHLRRSRQNVLELILKRFVLIGLLVAGLGIAIDTYWHGQLIVTPYEFLKYNIFNNIG 215
           + L      R+  ++ +LK  +  G+ +    + +D+++  +L+    E L YN   N  
Sbjct: 181 ILLVVSLLRRKVSIDGLLKVALPAGVCILAATVLVDSFFWRRLLWPEGEVLWYNTVLNKS 240

Query: 216 SFYGSHPWHWYFSVGLPTVLGINTLPFIFGVMETVKKSEKYPVSKQLLITIFLTLVVLSA 275
           S +G+ P+ WYF   LP  +G + +    GV          P  + L+++  L +++ S 
Sbjct: 241 SNWGTSPFLWYFYSALPRAMGASLVLVPIGV-------ALEPRIRPLVLSALLFVLLYSI 293

Query: 276 VEHKEFRFVSPLLPLCLYVITDALSR-WSIRASSTMLWTTALVI-----LVGNVMPAWYL 329
           + HKE RF+  + P+       A  R W   A ST  W + L +     L+ NV    +L
Sbjct: 294 LPHKELRFIIYVFPVLNIAAACACQRIWMNSAKST--WHSFLALACGAHLLLNVFITLFL 351

Query: 330 ---STVHQKGPIELMPKLREIAREYRDEREHQANILFLMPCHSTPYYSHIHQNVTM 382
              S  +  G    + +L  +     +      ++        +     +  N   
Sbjct: 352 LVISGTNYPGG-AALSRLHRL-----EAGTSNVSVHISNLAAQSGVSRFMEINNEW 401
>emb|CAD22101.1| (AJ429133) putative mannosyltransferase [Mus musculus]
          Length = 483

 Score =  300 bits (761), Expect = 4e-80
 Identities = 86/416 (20%), Positives = 159/416 (37%), Gaps = 55/416 (13%)

Query: 8   LLILAVRLASVFVVQTYYVPDEYWQSLEVAHKLTF------GYGYLTWEWVQGIRSYVYP 61
           LL L V +A++ +V   Y   E   +L+  H L +       Y +  +  V   R+++ P
Sbjct: 14  LLGLLVTVATIHLVICPYTKVEESFNLQATHDLLYHQLDIDKYDHHEFPGVVP-RTFLGP 72

Query: 62  LLIAGLYK----ILALLQLDSAH----------------LLVVLPRIRKWALFLILVPWF 101
           L+IA        +L+LL++   +                L  +   +R+     + V + 
Sbjct: 73  LVIAAFSSPVVYVLSLLEVSKFYSQLIVRGVLGLGVISGLWTLQKEVRQQFGATVAVMFC 132

Query: 102 W--------FYTGSRTLANTLEASLTTIALSYFPWYGESTAYLWPAAICCFLRPTAAVIW 153
           W         +  +RTL N L  ++   AL+ +        ++W +A           + 
Sbjct: 133 WISATQFHLMFYCTRTLPNVLALAVVLPALTAW-LQRRWALFVWLSAFVIIGFRAELAML 191

Query: 154 LPLSLYHLRRSRQNVLELILKRFVLIGLLVAGLGIAIDTYWHGQLIVTPYEFLKYNIFNN 213
           L ++L      R+  +  +L+  +  GLL  GL +A+D+Y+   L+      L YN   N
Sbjct: 192 LGIALLLTLYQRRLTVARVLRHAIPAGLLCLGLTVAVDSYFWRYLVWPEGVVLGYNTVLN 251

Query: 214 IGSFYGSHPWHWYFSVGLPTVLGINTLPFIFGVMETVKKSEKYPVSKQLLITIFLTLVVL 273
             S +G+ P  WYF   LP  LG + L    G ++    +        L +     + + 
Sbjct: 252 KSSNWGTSPLLWYFYSALPRGLGCSLLFIPLGAVDRRTYA--------LALPSLGFVALY 303

Query: 274 SAVEHKEFRFVSPLLPLCLYVITDALSRWSIRAS-----STMLWTTALVILVGNVMPAWY 328
           S + HKE RF+    P+   +     +    + S       ML T  +++ V     + Y
Sbjct: 304 SLLPHKELRFIIYTFPVLNIMAARGCTYILNKKSWPYKVRAMLVTGHILVNVAYTATSLY 363

Query: 329 LSTVHQKGPIELMPKLREIAREYRDEREHQANILFLMPCHSTPYYSHIHQNVTMRF 384
           +S  +  G +  M +L E+     D       +   +    T     +  N   R+
Sbjct: 364 VSHFNYPGGV-AMQQLHELVPPQTD-----VLLHIDVAAAQTGVSRFLQVNDDWRY 413
>gb|AAH21791.1|AAH21791 (BC021791) Similar to disrupted in bipolar disorder 1 [Mus
           musculus]
          Length = 611

 Score =  286 bits (726), Expect = 6e-76
 Identities = 83/333 (24%), Positives = 136/333 (39%), Gaps = 41/333 (12%)

Query: 7   FLLILAVRLASVFVVQTYYVPDEYWQSLEVAHKLTFGYGYLTWEW--VQGIRSYVYPLLI 64
           F  +L+ RL +  +       DE +   E  H L +G G+ TWE+  V  IRSY Y LL 
Sbjct: 62  FKCLLSARLCAALLSNISD-CDETFNYWEPTHYLIYGKGFQTWEYSPVYAIRSYAYLLLH 120

Query: 65  AG----------------LYKILALLQLDSAH--LLVVLPRIRKWAL--------FLILV 98
           A                  Y +  LL   S    L       +K+ L        FL+L 
Sbjct: 121 AWPAAFHARILQTNKILVFYFLRCLLAFVSCVCELYFYKAVCKKFGLHVSRMMLAFLVLS 180

Query: 99  PWFWFYTGSRTLANTLEASLTTIALSYFPWYGESTAYLWPAAICCFLRPTAAVIWLPLSL 158
               F + S  L ++     T IA++ +       A L  AA      P +A + LP++ 
Sbjct: 181 TGM-FCSSSAFLPSSFCMYTTLIAMTGWYMDKTPIAVLGVAAGAILGWPFSAALGLPIAF 239

Query: 159 YHLRRSRQNVLELILKRFVLIGLLVAGLGIAIDTYWHGQLIVTPYEFLKYNIFNNIG-SF 217
             L   R++  +  L   ++   L     + ID+Y++G+L+V P   + YN+F + G   
Sbjct: 240 DLLA--RKHRWKSFLLWSLVALALFLVPVVVIDSYYYGKLVVAPLNIVLYNVFTSHGPDL 297

Query: 218 YGSHPWHWYFSVGLP-----TVLGINTLPFIFGVMETVKKSEKYPVSKQLLI---TIFLT 269
           YG+ PW++Y   G         L +  LP  F +   +++     +     +    +++ 
Sbjct: 298 YGTEPWYFYLINGFLNFNVAFALALLVLPLTFLMEYLLQRFHVQNLGHPYWLTLAPMYIW 357

Query: 270 LVVLSAVEHKEFRFVSPLLPLCLYVITDALSRW 302
            ++     HKE RF+ P+ PL       ALS  
Sbjct: 358 FIIFFIQPHKEERFLFPVYPLICLCGAVALSAL 390
>emb|CAB66861.1| (AL136927) hypothetical protein [Homo sapiens]
          Length = 611

 Score =  285 bits (724), Expect = 9e-76
 Identities = 79/333 (23%), Positives = 133/333 (39%), Gaps = 41/333 (12%)

Query: 7   FLLILAVRLASVFVVQTYYVPDEYWQSLEVAHKLTFGYGYLTWEWV--QGIRSYVYPLLI 64
           F  +L+ RL +  +       DE +   E  H L +G G+ TWE+     IRSY Y LL 
Sbjct: 62  FKCLLSARLCAALLSNISD-CDETFNYWEPTHYLIYGEGFQTWEYSPAYAIRSYAYLLLH 120

Query: 65  AG----------------LYKILALLQLDSAH--LLVVLPRIRKWAL--------FLILV 98
           A                  Y +  LL   S    L       +K+ L        FL+L 
Sbjct: 121 AWPAAFHARILQTNKILVFYFLRCLLAFVSCICELYFYKAVCKKFGLHVSRMMLAFLVLS 180

Query: 99  PWFWFYTGSRTLANTLEASLTTIALSYFPWYGESTAYLWPAAICCFLRPTAAVIWLPLSL 158
               F + S  L ++     T IA++ +     S A L  AA      P +A + LP++ 
Sbjct: 181 TGM-FCSSSAFLPSSFCMYTTLIAMTGWYMDKTSIAVLGVAAGAILGWPFSAALGLPIAF 239

Query: 159 YHLRRSRQNVLELILKRFVLIGLLVAGLGIAIDTYWHGQLIVTPYEFLKYNIFNNIG-SF 217
             L    ++  +      ++  +L     + ID+Y++G+L++ P   + YN+F   G   
Sbjct: 240 DLLVM--KHRWKSFFHWSLMALILFLVPVVVIDSYYYGKLVIAPLNIVLYNVFTPHGPDL 297

Query: 218 YGSHPWHWYFSVGLP-----TVLGINTLPFIFGVMETVKKSEKYPVSKQLLI---TIFLT 269
           YG+ PW++Y   G         L +  LP    +   +++     +     +    +++ 
Sbjct: 298 YGTEPWYFYLINGFLNFNVAFALALLVLPLTSLMEYLLQRFHVQNLGHPYWLTLAPMYIW 357

Query: 270 LVVLSAVEHKEFRFVSPLLPLCLYVITDALSRW 302
            ++     HKE RF+ P+ PL       ALS  
Sbjct: 358 FIIFFIQPHKEERFLFPVYPLICLCGAVALSAL 390
>gb|AAH09255.1|AAH09255 (BC009255) hypothetical protein FLJ21845 [Homo sapiens]
          Length = 618

 Score =  284 bits (721), Expect = 3e-75
 Identities = 79/333 (23%), Positives = 133/333 (39%), Gaps = 41/333 (12%)

Query: 7   FLLILAVRLASVFVVQTYYVPDEYWQSLEVAHKLTFGYGYLTWEWV--QGIRSYVYPLLI 64
           F  +L+ RL +  +       DE +   E  H L +G G+ TWE+     IRSY Y LL 
Sbjct: 62  FKCLLSARLCAALLSNISD-CDETFNYWEPTHYLIYGEGFQTWEYSPAYAIRSYAYLLLH 120

Query: 65  AG----------------LYKILALLQLDSAH--LLVVLPRIRKWAL--------FLILV 98
           A                  Y +  LL   S    L       +K+ L        FL+L 
Sbjct: 121 AWPAAFHARILQTNKILVFYFLRCLLAFVSCICELYFYKAVCKKFGLHVSRMMLAFLVLS 180

Query: 99  PWFWFYTGSRTLANTLEASLTTIALSYFPWYGESTAYLWPAAICCFLRPTAAVIWLPLSL 158
               F + S  L ++     T IA++ +     S A L  AA      P +A + LP++ 
Sbjct: 181 TGM-FCSSSAFLPSSFCMYTTLIAMTGWYMDKTSIAVLGVAAGAILGWPFSAALGLPIAF 239

Query: 159 YHLRRSRQNVLELILKRFVLIGLLVAGLGIAIDTYWHGQLIVTPYEFLKYNIFNNIG-SF 217
             L    ++  +      ++  +L     + ID+Y++G+L++ P   + YN+F   G   
Sbjct: 240 DLLVM--KHRWKSFFHWSLMALILFLVPVVVIDSYYYGKLVIAPLNIVLYNVFTPHGPDL 297

Query: 218 YGSHPWHWYFSVGLP-----TVLGINTLPFIFGVMETVKKSEKYPVSKQLLI---TIFLT 269
           YG+ PW++Y   G         L +  LP    +   +++     +     +    +++ 
Sbjct: 298 YGTEPWYFYLINGFLNFNVAFALALLVLPLTSLMEYLLQRFHVQNLGHPYWLTLAPMYIW 357

Query: 270 LVVLSAVEHKEFRFVSPLLPLCLYVITDALSRW 302
            ++     HKE RF+ P+ PL       ALS  
Sbjct: 358 FIIFFIQPHKEERFLFPVYPLICLCGAVALSAL 390
>gb|AAL25798.1| (AF395532) DIBD1 [Homo sapiens]
          Length = 611

 Score =  283 bits (719), Expect = 4e-75
 Identities = 79/333 (23%), Positives = 133/333 (39%), Gaps = 41/333 (12%)

Query: 7   FLLILAVRLASVFVVQTYYVPDEYWQSLEVAHKLTFGYGYLTWEWV--QGIRSYVYPLLI 64
           F  +L+ RL +  +       DE +   E  H L +G G+ TWE+     IRSY Y LL 
Sbjct: 62  FKCLLSARLCAALLSNISD-CDETFNYWEPTHYLIYGEGFQTWEYSPAYAIRSYAYLLLH 120

Query: 65  AG----------------LYKILALLQLDSAH--LLVVLPRIRKWAL--------FLILV 98
           A                  Y +  LL   S    L       +K+ L        FL+L 
Sbjct: 121 AWPAAFHARILQTNKILVFYFLRCLLAFVSCICELYFYKAVCKKFGLHVSRMMLAFLVLS 180

Query: 99  PWFWFYTGSRTLANTLEASLTTIALSYFPWYGESTAYLWPAAICCFLRPTAAVIWLPLSL 158
               F + S  L ++     T IA++ +     S A L  AA      P +A + LP++ 
Sbjct: 181 TGM-FCSSSAFLPSSFCMYTTLIAMTGWYMDKTSIAVLGVAAGAILGWPFSAALGLPIAF 239

Query: 159 YHLRRSRQNVLELILKRFVLIGLLVAGLGIAIDTYWHGQLIVTPYEFLKYNIFNNIG-SF 217
             L    ++  +      ++  +L     + ID+Y++G+L++ P   + YN+F   G   
Sbjct: 240 DLLVM--KHRWKSFFHWSLMALILFLVPVVVIDSYYYGKLVIAPLNIVLYNVFTPHGPDL 297

Query: 218 YGSHPWHWYFSVGLP-----TVLGINTLPFIFGVMETVKKSEKYPVSKQLLI---TIFLT 269
           YG+ PW++Y   G         L +  LP    +   +++     +     +    +++ 
Sbjct: 298 YGTEPWYFYLIKGFLNFNVAFALALLVLPLTSLMEYLLQRFHVQNLGHPYWLTLAPMYIW 357

Query: 270 LVVLSAVEHKEFRFVSPLLPLCLYVITDALSRW 302
            ++     HKE RF+ P+ PL       ALS  
Sbjct: 358 FIIFFIQPHKEERFLFPVYPLICLCGAVALSAL 390
>ref|NP_079016.1| (NM_024740) disrupted in bipolar disorder 1; similar to putative
           mannosyltransferase Alg9p (S. cerevisiae) [Homo sapiens]
 dbj|BAB15154.1| (AK025498) unnamed protein product [Homo sapiens]
          Length = 618

 Score =  283 bits (717), Expect = 8e-75
 Identities = 80/333 (24%), Positives = 133/333 (39%), Gaps = 41/333 (12%)

Query: 7   FLLILAVRLASVFVVQTYYVPDEYWQSLEVAHKLTFGYGYLTWEWV--QGIRSYVYPLLI 64
           F  +L+ RL +  +       DE +   E  H L +G G+ TWE+     IRSY Y LL 
Sbjct: 62  FKCLLSARLCAALLSNISD-CDETFNYWEPTHYLIYGEGFQTWEYSPAYAIRSYAYLLLH 120

Query: 65  AG----------------LYKILALLQLDSAH--LLVVLPRIRKWAL--------FLILV 98
           A                  Y +  LL   S    L       +K+ L        FL+L 
Sbjct: 121 AWPAAFHARILQTNKILVFYFLRCLLAFVSCICELYFYKAVCKKFGLHVSRMMLAFLVLS 180

Query: 99  PWFWFYTGSRTLANTLEASLTTIALSYFPWYGESTAYLWPAAICCFLRPTAAVIWLPLSL 158
               F + S  L ++     T IA++ +     S A L  AA      P +A + LP++ 
Sbjct: 181 TGM-FCSSSAFLPSSFCMYTTLIAMTGWYMDKTSIAVLGVAAGAILGWPFSAALGLPIAF 239

Query: 159 YHLRRSRQNVLELILKRFVLIGLLVAGLGIAIDTYWHGQLIVTPYEFLKYNIFNNIG-SF 217
             L    ++  +      ++  +L     + ID+Y++G+L++ P   + YNIF   G   
Sbjct: 240 DLLVM--KHRWKSFFHWSLMALILFLVPVVVIDSYYYGKLVIAPLNIVLYNIFTPHGPDL 297

Query: 218 YGSHPWHWYFSVGLP-----TVLGINTLPFIFGVMETVKKSEKYPVSKQLLI---TIFLT 269
           YG+ PW++Y   G         L +  LP    +   +++     +     +    +++ 
Sbjct: 298 YGTEPWYFYLINGFLNFNVAFALALLVLPLTSLMEYLLQRFHVQNLGHPYWLTLAPMYIW 357

Query: 270 LVVLSAVEHKEFRFVSPLLPLCLYVITDALSRW 302
            ++     HKE RF+ P+ PL       ALS  
Sbjct: 358 FIIFFIQPHKEERFLFPVYPLICLCGAVALSAL 390
>ref|NP_077010.1| (NM_024105) hypothetical protein MGC3136 [Homo sapiens]
 gb|AAH01729.1|AAH01729 (BC001729) Unknown (protein for MGC:3136) [Homo sapiens]
 emb|CAC67488.1| (AJ303120) putative alpha mannosyltransferase [Homo sapiens]
 gb|AAL55850.1|AF318343_1 (AF318343) unknown [Homo sapiens]
          Length = 488

 Score =  274 bits (694), Expect = 4e-72
 Identities = 89/419 (21%), Positives = 163/419 (38%), Gaps = 57/419 (13%)

Query: 7   FLLILAVRLASVFVVQTYYVPDEYWQSLEVAHKLTF------GYGYLTWEWVQGIRSYVY 60
            LL L V +A+V +V   Y   E   +L+  H L +       Y +L +  V   R+++ 
Sbjct: 12  LLLGLLVAVATVHLVICPYTKVEESFNLQATHDLLYHWQDLEQYDHLEFPGVVP-RTFLG 70

Query: 61  PLLIAGLYK----ILALLQLDSAH----------------LLVVLPRIRKWALFLILVPW 100
           P++IA        +L+LL++   +                L  +   +R+    ++   +
Sbjct: 71  PVVIAVFSSPAVYVLSLLEMSKFYSQLIVRGVLGLGVIFGLWTLQKEVRRHFGAMVATMF 130

Query: 101 FW--------FYTGSRTLANTLEASLTTIALSYFPWYGESTAYLWPAAICCFLRPTAAVI 152
            W         +  +RTL N L   +  +AL+ +  + E   ++W +A    +      +
Sbjct: 131 CWVTAMQFHLMFYCTRTLPNVLALPVVLLALAAWLRH-EWARFIWLSAFAIIVFRVELCL 189

Query: 153 WLPLSLYHLRRSRQNVLELILKRFVLIGLLVAGLGIAIDTYWHGQLIVTPYEFLKYNIFN 212
           +L L L     +R+  +   L+  V  G+L  GL +A+D+Y+  QL     + L YN   
Sbjct: 190 FLGLLLLLALGNRKVSVVRALRHAVPAGILCLGLTVAVDSYFWRQLTWPEGKVLWYNTVL 249

Query: 213 NIGSFYGSHPWHWYFSVGLPTVLGINTLPFIFGVMETVKKSEKYPVSKQLLITIFLTLVV 272
           N  S +G+ P  WYF   LP  LG + L    G+++      +   +  +L   F+   +
Sbjct: 250 NKSSNWGTSPLLWYFYSALPRGLGCSLLFIPLGLVD------RRTHAPTVLALGFM--AL 301

Query: 273 LSAVEHKEFRFVSPLLPLCLYVITDALSRWSIRASS-------TMLWTTALVILVGNVMP 325
            S + HKE RF+    P+         S               ++L    LV+       
Sbjct: 302 YSLLPHKELRFIIYAFPMLNITAARGCSYLLNNYKKSWLYKAGSLLVIGHLVVNAAYSAT 361

Query: 326 AWYLSTVHQKGPIELMPKLREIAREYRDEREHQANILFLMPCHSTPYYSHIHQNVTMRF 384
           A Y+S  +  G +  M +L ++     D       +   +    T     +  N   R+
Sbjct: 362 ALYVSHFNYPGGV-AMQRLHQLVPPQTD-----VLLHIDVAAAQTGVSRFLQVNSAWRY 414
>emb|CAC83681.1| (AJ290427) putative dolichyl-p-man: Man7GlcNAc2-PP-dolichyl
           mannosyltransferase [Homo sapiens]
          Length = 488

 Score =  273 bits (692), Expect = 6e-72
 Identities = 89/419 (21%), Positives = 162/419 (38%), Gaps = 57/419 (13%)

Query: 7   FLLILAVRLASVFVVQTYYVPDEYWQSLEVAHKLTF------GYGYLTWEWVQGIRSYVY 60
            LL L V +A+V +V   Y   E   +L+  H L +       Y +L +  V   R+++ 
Sbjct: 12  LLLGLLVAVATVHLVICPYTKVEESFNLQATHDLLYHWQDLEQYDHLEFPGVVP-RTFLG 70

Query: 61  PLLIAGLYK----ILALLQLDSAH----------------LLVVLPRIRKWALFLILVPW 100
           P++IA        +L+LL++   +                L  +   +R+    ++   +
Sbjct: 71  PVVIAVFSSPAVYVLSLLEMSKFYSQLIVRGVLGLGVIFGLWTLQKEVRRHFGAMVATMF 130

Query: 101 FW--------FYTGSRTLANTLEASLTTIALSYFPWYGESTAYLWPAAICCFLRPTAAVI 152
            W            +RTL N L   +  +AL+ +  + E   ++W +A    +      +
Sbjct: 131 CWVTAMQFHLMVYCTRTLPNVLALPVVLLALAAWLRH-EWARFIWLSAFAIIVFRVELCL 189

Query: 153 WLPLSLYHLRRSRQNVLELILKRFVLIGLLVAGLGIAIDTYWHGQLIVTPYEFLKYNIFN 212
           +L L L     +R+  +   L+  V  G+L  GL +A+D+Y+  QL     + L YN   
Sbjct: 190 FLGLLLLLALGNRKVSVVRALRHAVPAGILCLGLTVAVDSYFWRQLTWPEGKVLWYNTVL 249

Query: 213 NIGSFYGSHPWHWYFSVGLPTVLGINTLPFIFGVMETVKKSEKYPVSKQLLITIFLTLVV 272
           N  S +G+ P  WYF   LP  LG + L    G+++      +   +  +L   F+   +
Sbjct: 250 NKSSNWGTSPLLWYFYSALPRGLGCSLLFIPLGLVD------RRTHAPTVLALGFM--AL 301

Query: 273 LSAVEHKEFRFVSPLLPLCLYVITDALSRWSIRASS-------TMLWTTALVILVGNVMP 325
            S + HKE RF+    P+         S               ++L    LV+       
Sbjct: 302 YSLLPHKELRFIIYAFPMLNITAARGCSYLLNNYKKSWLYKAGSLLVIGHLVVNAAYSAT 361

Query: 326 AWYLSTVHQKGPIELMPKLREIAREYRDEREHQANILFLMPCHSTPYYSHIHQNVTMRF 384
           A Y+S  +  G +  M +L ++     D       +   +    T     +  N   R+
Sbjct: 362 ALYVSHFNYPGGV-AMQRLHQLVPPQTD-----VLLHIDVAAAQTGVSRFLQVNSAWRY 414
>ref|NP_505071.1| (NM_072670) ZC513.5.p [Caenorhabditis elegans]
 gb|AAC48267.3| (U53155) Hypothetical protein ZC513.5 [Caenorhabditis elegans]
          Length = 492

 Score =  269 bits (683), Expect = 6e-71
 Identities = 77/413 (18%), Positives = 147/413 (34%), Gaps = 58/413 (14%)

Query: 15  LASVFVVQTYYVPDEYWQSLEVAHKLTF-------GYGYLTWEWVQGIRSYVYPLLIAGL 67
           +  + ++       E   +++  H L F        Y +  +  V   R+++ P+ +A L
Sbjct: 11  VTIIHIILAPGTKVEESFNVQATHDLMFHLPTNLSNYDHSQFPGVVP-RTFIGPISLAIL 69

Query: 68  YK-------------------ILALLQLDS--AHLLVVLPRIRKWA------LFLILV-P 99
                                I A L L +  A L       RK+       L LI+   
Sbjct: 70  SSPMSFIFRFWAIPKMWQLLLIRATLGLMNAMAFLYFARSVNRKFGRETAMYLRLIMCTQ 129

Query: 100 WFWFYTGSRTLANTLEASLTTIALSYFPWYGESTAYLWPAAICCFLRPTAAVIWLPLSLY 159
           + + +  SR L NT    L  I +      G   + +  A     L     V+       
Sbjct: 130 FHYIFYMSRPLPNTFALILVMI-VFERLLEGRYESAVRYATASVILFRCELVLLYGPIFL 188

Query: 160 ---HLRRSRQNVLELILKRFVLIGLLVAGLGIAIDTYWHGQLIVTPYEFLKYNIFNNIGS 216
                 R +    +  +   V I  +   + I ID+Y+ G+ +    E + +N+  N   
Sbjct: 189 GYMISGRLKVFGFDGAIAIGVRIAAMCLAVSIPIDSYFWGRPLWPEGEVMFFNVVENRSH 248

Query: 217 FYGSHPWHWYFSVGLPTVLGINTLPFIFGVMETVKKSEKYPVSKQLLITIFLTLVVLSAV 276
            YG+ P+ WYF   LP  L   TL    G++   +         Q+++   + + + S +
Sbjct: 249 EYGTQPFLWYFYSALPRCLLTTTLLVPLGLLVDRRL-------PQIVLPSVIFIFLYSFL 301

Query: 277 EHKEFRFVSPLLPLCLYVITDALSRWSIRASST----MLWTTALVILVGNV---MPAWYL 329
            HKE RF+  +LP+         +R  I    +    +L+   ++ L+ NV        +
Sbjct: 302 PHKELRFIIYVLPIFCLSAAVFCARMLINRHKSFFRMILFFGVILHLLANVLCTGMFLLV 361

Query: 330 STVHQKGPIELMPKLREIAREYRDEREHQANILFLMPCHSTPYYSHIHQNVTM 382
           ++ +  G  + +  L+    + R + +    +     C  T     +H N   
Sbjct: 362 ASKNYPG-FDALNYLQ---FQNRFDAKKPVTVYIDNACAQTGVNRFLHINDAW 410
>dbj|BAA94863.1| (AB033824) GPI anchor biosynthesis protein [Trypanosoma brucei]
          Length = 558

 Score =  261 bits (661), Expect = 3e-68
 Identities = 89/313 (28%), Positives = 158/313 (50%), Gaps = 23/313 (7%)

Query: 92  ALFLILVPWFWFYTGSRTLANTLEASLTTIALSYFPWYGESTAYLWPAAICCFLRPTAAV 151
           AL L L  W+  Y G R   N +EA L  + L           +L    +   +R T+AV
Sbjct: 153 ALLLSLSNWYMAYCGVRLYGNVIEALLVLLTL----QQRRYVPFLLLTGLASAIRVTSAV 208

Query: 152 IWLPLSLYHLRR-SRQNVLELILKRFVLIGLL----VAGLGIAIDTYWHGQLIVTPYEFL 206
           +  PL   HL   +R++     L R VL GL+    V G  + +D  ++G+ ++TP  F 
Sbjct: 209 VLSPLVFRHLANATREHGFIRGLFRIVLTGLIVLVAVLGGVMVLDYCFYGRWVLTPLAFF 268

Query: 207 KYNIFNNIGSFYGSHPWHWYFSVGLPTVLGINTLPFIFGVMETVKKSEKYPVSKQLLITI 266
           ++N+ +N+  F+G HPW++Y    L  ++G + L  I   +   + +    VS+ +L  +
Sbjct: 269 RFNVLHNLSRFFGEHPWYFYVGPVLVGIVGPHVLFTIAAPLVLWRDTASRAVSRPVLGML 328

Query: 267 ---FLTLVVLSAVEHKEFRFVSPLLPLCLYVITDALSRWSIRASSTMLWTTALVILVGNV 323
                TL   S ++HKE RFV  ++PL L      L RWS R S+ ++    L +L  N+
Sbjct: 329 GIGAWTLGFYSLIDHKEMRFVFVVIPLSLITAAFVLVRWS-RTSAVVVKMNRLFVL-FNI 386

Query: 324 MPAWYLSTVHQKGPIELMPKLREIAREYRDEREHQANILFLMPCHSTPYYSHIHQNVT-M 382
           +  + +  V+++GP+++M ++R+  R  R        +  +  C++ P YS++H+ V  +
Sbjct: 387 VMIYLMGYVYRRGPLDVMAEVRDGPRINR--------LDVIATCYTVPGYSYMHKKVNHL 438

Query: 383 RFLTCEPNLEKKE 395
            F+ C  +L++K 
Sbjct: 439 GFVDCSIDLDEKT 451
 Score =  103 bits (256), Expect = 8e-21
 Identities = 33/106 (31%), Positives = 56/106 (52%), Gaps = 2/106 (1%)

Query: 5   YVFLLILAVRLASVFVVQTYYVPDEYWQSLEVAHKLTFGYGYLTWEWVQGIRSYVYPLLI 64
           ++  L    RL     ++T   PDE+WQS EVA+ + FG G+L WEW  G+RS ++P ++
Sbjct: 4   WLISLTFIYRLFLCATIRTVEAPDEWWQSTEVAYNMVFGKGHLPWEWRYGLRSVLFPAVV 63

Query: 65  AGLYKILALLQLDSAHLLVVLPRIRKWALFLILVPWFWFYTGSRTL 110
           A  + +L LL  D+   +   PR+ +  +  ++      +    TL
Sbjct: 64  ALPFYLLKLLGRDTTWAVWFAPRVLQALVLTLIDV--SVFCMGATL 107
>ref|XP_081472.1| (XM_081472) CG11851 [Drosophila melanogaster]
 gb|AAF56419.1| (AE003751) CG11851 gene product [Drosophila melanogaster]
 gb|AAL39788.1| (AY069643) LD40966p [Drosophila melanogaster]
          Length = 623

 Score =  259 bits (657), Expect = 7e-68
 Identities = 95/397 (23%), Positives = 150/397 (36%), Gaps = 63/397 (15%)

Query: 7   FLLILAVRLASVFVVQTYYVPDEYWQSLEVAHKLTFGYGYLTWEWV--QGIRSYVYPLL- 63
           F   ++ RL S          DE +   E  H +  G+G  TWE+    G+RSY Y LL 
Sbjct: 77  FKTFVSARLCSAIWAYIAD-CDETFNYWEPLHYIINGHGLQTWEYSPQFGLRSYTYLLLQ 135

Query: 64  ---------------IAGLYKILALLQLDSAHLLVVLPRI----------RKWALFLILV 98
                          I   Y +  +L    A +   + +           R W +F +  
Sbjct: 136 GVPGYFYQKLFNPSPILIFYMVRCMLGFGCAVMERYMYKSICQEFGIHIGRLWLIFQLFS 195

Query: 99  PWFWFYTGSRTLANTLEASLTTIALSYFPWYGESTAYLWPAAI-CCFLRPTAAVIWLPLS 157
               F + +  L ++        AL+ + W       ++  AI      P AA+I +PL 
Sbjct: 196 VGM-FVSSTALLPSSFSMYFGCAALAAW-WQQNYCFAIFLTAISALLGWPFAALIGIPLV 253

Query: 158 LYHLRRSRQNVLELILKRFVLIGLLVAGLGIAIDTYWHGQLIVTPYEFLKYNIFNNIG-S 216
           L  L R R    +  ++  ++ G  VA   IAIDT + G+L   P   + YN+F + G +
Sbjct: 254 LEMLLRQRD--WKTFVQWTLISGATVAIPMIAIDTSYFGKLTFAPLNIVWYNVFTSHGPN 311

Query: 217 FYGSHPWHWYFSVGLPTV----LGINTLPFIFGVMETV-----KKSEKYPVSKQLLITIF 267
            +G+ P  +Y   G        L    LP +  +   +     K +  +P    L   ++
Sbjct: 312 IFGTEPLSYYIINGFLNFNIIWLLALQLPIMLVIDYLIVPAKSKSTLNFPHYISL-APLY 370

Query: 268 LTLVVLSAVEHKEFRFVSPLLPLCLYVIT---DALSRWSIRASSTMLWTT---------- 314
           L L+V  A  HKE RF+ P+ PL         D   R   R  S +              
Sbjct: 371 LWLLVFFAQPHKEERFLFPIYPLISLCGAITVDVYQRIFFRMKSVVFKIKAGVHYLDHSM 430

Query: 315 ALVILVGNVMPAWYLSTV-----HQKGPIELMPKLRE 346
            + ILV        LS V     +   P++LM +L +
Sbjct: 431 FIAILVMVTSTLLGLSRVFALYRNYHAPMDLMLELNQ 467
>pir||T50116 probable mannosyltransferase involved in N-glycosylation [imported]
           - fission yeast (Schizosaccharomyces pombe)
 emb|CAB75773.1| (AL157734) putative mannosyltransferase involved in N-glycosylation
           [Schizosaccharomyces pombe]
          Length = 577

 Score =  251 bits (637), Expect = 2e-65
 Identities = 70/341 (20%), Positives = 128/341 (37%), Gaps = 44/341 (12%)

Query: 1   MKLIYVFLLILAVRLASVFVVQTYYVPDEYWQSLEVAHKLTFGYGYLTWEWV--QGIRSY 58
           +  ++ F ++  +RL S    +     DE +   E  H L +GYG  TWE+     IRS+
Sbjct: 12  VSFVWTFSILAVLRLTSASF-RVIDDCDEVYNYWEPLHYLLYGYGLQTWEYSPEYAIRSW 70

Query: 59  VYPLLIA---------------GLYKILALLQLDSAH----LLVVLPRIRKWALFLILVP 99
            Y  L A                 Y I  +L   SA     L++ + R    A+ L L  
Sbjct: 71  FYIALHAVPGFLARGLGLSRLHVFYFIRGVLACFSAFCETNLILAVARNFNRAVALHLTS 130

Query: 100 WFWFYT-----GSRTLANTLEASLTTIALSYFP----WYGESTAYLWPAAICCFLRPTAA 150
             +  +      +  L ++   ++ T+ALS                +         P +A
Sbjct: 131 VLFVNSGMWSASTSFLPSSFAMNMVTLALSAQLSPPSTKRTVKVVSFITIGAVIGWPFSA 190

Query: 151 VIWLPLSLYHLRRSRQNVLELILKRF--VLIGLLVAGLGIAIDTYWHGQLIVTPYEFLKY 208
            + +P  L  L   +     L  + F  + + LL+ G+ I +D+ ++ ++    +  +KY
Sbjct: 191 ALSIPFILLELVDLKGRFRHLFCRWFKAIFVALLITGICITVDSLFYHRIQFVAWNIVKY 250

Query: 209 NIFNNIG---SFYGSHPWHWYFSV-------GLPTVLGINTLPFIFGVMETVKKSEKYPV 258
           N+    G     YG+ PW +YF+         L   +    L  +      +       +
Sbjct: 251 NVLAKDGRGPDIYGTEPWWYYFANLSLQHNIVLWFAMACGPLVLLAAFTNWINLDSFLDL 310

Query: 259 SKQLLITIFLTLVVLSAVEHKEFRFVSPLLPLCLYVITDAL 299
           S  ++   ++ L +     HKE RF+ P+ P+        L
Sbjct: 311 S-SVISPFYIWLFIFIIQPHKEERFMYPIYPVLCLAAAIGL 350
>pir||T39659 cell wall biosynthesis protein N3265 homolog - fission yeast
           (Schizosaccharomyces pombe)
 emb|CAA21306.1| (AL031856) putative involvement in cell wall biogenesis and
           architecture [Schizosaccharomyces pombe]
          Length = 547

 Score =  250 bits (634), Expect = 4e-65
 Identities = 68/405 (16%), Positives = 128/405 (30%), Gaps = 57/405 (14%)

Query: 2   KLIYVFLLILAVRLASVFVVQTYYVPDEYWQSLEVAHKL-------TFGYGYLTWEWVQG 54
            + +    IL V     +  +T +   E   +++  H +       +  Y +L +     
Sbjct: 6   SICWYLANILLVTCIGYYSYKTPFTKVEESFAMQAIHDIQTYRWDLSKVYDHLEFPGAVK 65

Query: 55  IRSYVYPLLIAGLYKILAL--------------------LQLDSAHLLVVLPRIRKWALF 94
            RS++  L IA L  I +                       +  +             + 
Sbjct: 66  -RSFIPSLFIAVLSYIPSWFVNPLLAARWTIGYLSWESMNSVSCSISKRFGTLSGALFIL 124

Query: 95  LILVPWFWFYTGSRTLANTLEASLTTIALSYFPWYGESTAYLWPAAICCFLRPTAAVIWL 154
                +   Y  SR L+N      T  +LS           +        +  +   + L
Sbjct: 125 FSCAQFHLVYYMSRPLSNIFGLIATNHSLSL-LLKNNYYGSISILVFAAAIVRSEIALLL 183

Query: 155 PLSLYHLRRSRQNVLELILKRFVLIGLLVAGLGIAIDTYWHGQLIVTPYEFLKYNIFNNI 214
              +  L   R+  L  +L   +   L   G    ID+Y+ G       E   +N+    
Sbjct: 184 MCLILPLLLQRRITLSKLLLVGISSSLAAVGASFLIDSYFWGAWCWPELEAFLFNVVEGK 243

Query: 215 GSFYGSHPWHWYFSVGLPTVLGINTLPFIFGVMETVKKSEKYPVSKQLLITIFLTLVVLS 274
            S +G+ P+++YF       L   TL F+      +K       ++ L+      + V S
Sbjct: 244 SSDWGTSPFYYYFVRLPWLFLNPTTLLFLLISFVYIK------PARLLIYVPLFFIFVYS 297

Query: 275 AVEHKEFRFVSPLLP-----------LCLYVITDALSRWSIRASSTMLWTTALVILVGNV 323
            + HKE+RF+   +P           LC          + I     M ++  +   +G+ 
Sbjct: 298 FLGHKEWRFIIYSIPWFNAASAIGASLCFNASKFGKKIFEILRL--MFFSGIIFGFIGSS 355

Query: 324 MPAWYLSTVHQKGPIELMPKLREIAREYRDEREHQANILF-LMPC 367
               Y+      G +        + R Y  E   Q ++   + PC
Sbjct: 356 FL-LYVFQYAYPGGLA-------LTRLYEIENHPQVSVHMDVYPC 392
>pir||T28996 hypothetical protein ZC513.5 - Caenorhabditis elegans
          Length = 369

 Score =  247 bits (626), Expect = 3e-64
 Identities = 73/378 (19%), Positives = 136/378 (35%), Gaps = 51/378 (13%)

Query: 43  GYGYLTWEWVQGIRSYVYPLLIAGLYK-------------------ILALLQLDS--AHL 81
            Y +  +  V   R+++ P+ +A L                     I A L L +  A L
Sbjct: 4   KYDHSQFPGVVP-RTFIGPISLAILSSPMSFIFRFWAIPKMWQLLLIRATLGLMNAMAFL 62

Query: 82  LVVLPRIRKWA------LFLILV-PWFWFYTGSRTLANTLEASLTTIALSYFPWYGESTA 134
                  RK+       L LI+   + + +  SR L NT    L  I +      G   +
Sbjct: 63  YFARSVNRKFGRETAMYLRLIMCTQFHYIFYMSRPLPNTFALILVMI-VFERLLEGRYES 121

Query: 135 YLWPAAICCFLRPTAAVIWLPLSLY---HLRRSRQNVLELILKRFVLIGLLVAGLGIAID 191
            +  A     L     V+             R +    +  +   V I  +   + I ID
Sbjct: 122 AVRYATASVILFRCELVLLYGPIFLGYMISGRLKVFGFDGAIAIGVRIAAMCLAVSIPID 181

Query: 192 TYWHGQLIVTPYEFLKYNIFNNIGSFYGSHPWHWYFSVGLPTVLGINTLPFIFGVMETVK 251
           +Y+ G+ +    E + +N+  N    YG+ P+ WYF   LP  L   TL    G++   +
Sbjct: 182 SYFWGRPLWPEGEVMFFNVVENRSHEYGTQPFLWYFYSALPRCLLTTTLLVPLGLLVDRR 241

Query: 252 KSEKYPVSKQLLITIFLTLVVLSAVEHKEFRFVSPLLPLCLYVITDALSRWSIRASST-- 309
                    Q+++   + + + S + HKE RF+  +LP+         +R  I    +  
Sbjct: 242 L-------PQIVLPSVIFIFLYSFLPHKELRFIIYVLPIFCLSAAVFCARMLINRHKSFF 294

Query: 310 --MLWTTALVILVGNV---MPAWYLSTVHQKGPIELMPKLREIAREYRDEREHQANILFL 364
             +L+   ++ L+ NV        +++ +  G  + +  L+    + R + +    +   
Sbjct: 295 RMILFFGVILHLLANVLCTGMFLLVASKNYPG-FDALNYLQ---FQNRFDAKKPVTVYID 350

Query: 365 MPCHSTPYYSHIHQNVTM 382
             C  T     +H N   
Sbjct: 351 NACAQTGVNRFLHINDAW 368
>sp|Q09837|YADC_SCHPO HYPOTHETICAL 62.2 KD PROTEIN C4G8.12C IN CHROMOSOME I
 pir||S62489 hypothetical protein SPAC4G8.12c - fission yeast
           (Schizosaccharomyces pombe)
 pir||T38857 hypothetical protein SPAC4G8.12c - fission yeast
           (Schizosaccharomyces pombe)
 emb|CAA91213.1| (Z56276) hypothetical protein [Schizosaccharomyces pombe]
          Length = 533

 Score =  241 bits (610), Expect = 2e-62
 Identities = 78/425 (18%), Positives = 147/425 (34%), Gaps = 77/425 (18%)

Query: 3   LIYVFLLILAVRLASVFVVQTYYVPDEYWQSLEVAHKLTFGYGY-LTWEW--VQGIRSYV 59
           +IY FLLIL    +      +Y  PDE+ QS ++     FG+   L WE+   + IRS V
Sbjct: 9   IIYTFLLILRFWFSQG---SSYIHPDEHLQSFQIFANKLFGWKVELPWEFTTKKPIRSVV 65

Query: 60  YPLLIAGLYKILALLQLDS-----AHLLVV------------------LPRIRKW-ALFL 95
              ++     +L      S       LL                    +P   +W AL L
Sbjct: 66  PLNVMLLPIFLLCRCICKSNCSPYPILLFTRLYMCLISLLIDLSIWNIVPLNARWSALLL 125

Query: 96  ILVPWFWFYTGSRTLANTLEASLTTIALSYFPWYGE-------STAYLWPAAICCFLR-- 146
               +      + T  N++E     + + +             S  Y +  AI   L   
Sbjct: 126 YSSSFMATTFQTHTFTNSIETIFFFLTILFLSKLNSVPLNKKISYLYTFLLAIVSVLGFF 185

Query: 147 ------PTAAVIWLPLSLYHLRRSRQNVLELILKRFVLIGLLVAGL--GIAIDTYWHGQL 198
                       ++  S+   +++  N  ++ L   + + +  A +   I  D  ++G  
Sbjct: 186 TRITFLAFVIAPYIYFSVRCFKKNVNNPKDIFLHLCIFVSVSFATVLACILEDYKFYGVF 245

Query: 199 IVTPYEFLKYNIFNNIGSFYGSHPWHWYFSVGLPTVLGINTLPFIFGVMETVKKSEKYPV 258
           ++T +  LKYN      S +G H    +F   +P + G         +        + P 
Sbjct: 246 VITFWNNLKYNSQIENLSQHGLHSRLTHFFTNMPLLCGP-------LIFVPKLWDVRKPA 298

Query: 259 SKQLLITIFLTLVVLSAVEHKEFRFVSPLLPLCLYVITDALSRWSIRASSTMLWTTALVI 318
           +   L+ +F    +LS   H+E RF+ P   + +      +  +         W   L +
Sbjct: 299 TWLWLLPVF----ILSLFPHQEPRFLLPAASIFIVNSGCLVRSY---------WIKFLFV 345

Query: 319 LVGNVMPAWYLSTVHQKGPIELMPKLREIARE---------YRDEREHQANILFLMPCHS 369
           +   V+ A +   +HQ G I  + +++ I  +                    ++    +S
Sbjct: 346 MYA-VVLAVFFGIMHQNGVIPAVLEVKNIIEQRNVTTMENCNLYFNPEMPTTIYFWKIYS 404

Query: 370 TPYYS 374
            P + 
Sbjct: 405 APTWM 409
>emb|CAA41123.1| (X58121) SMP3 protein [Saccharomyces cerevisiae]
          Length = 516

 Score =  240 bits (609), Expect = 3e-62
 Identities = 92/428 (21%), Positives = 161/428 (37%), Gaps = 69/428 (16%)

Query: 5   YVFLLILAVRLASVFVVQTYY-VPDEYWQSLEV-AHKLTFGYGYLTWEW--VQGIRSYVY 60
           Y + L L   +  +  +   Y  PDE++Q +E+ A +     G + WE+      RSY  
Sbjct: 4   YQWWLYLVYAIGLMLCLGPSYIHPDEHFQCIEILAMQFMKVKGTIPWEFKSKFAARSYGP 63

Query: 61  PLLIAGLYK---------------ILALLQLDSAHLL-----VVLPRI----RKWALF-- 94
            LL+ G                  IL  ++L +  +       ++P++    RK   F  
Sbjct: 64  LLLVYGPLFTILESFPEIQDNPALILYSMRLQNYVMYLLCYHFLIPKLIRDERKAVQFIK 123

Query: 95  --LILVPWFWFYTGSRTLANTLEASLTTIALSYFP--------WYGESTAYLWPAAICCF 144
             L+L  +  +   + T +N++E       L+                   +    I  F
Sbjct: 124 KSLLLTSYVTWTYQTHTFSNSIETLALISTLTVMEDMVNGKNIQRRNFKNSVILGLIFSF 183

Query: 145 L----RPTAAVIWLPLSLYHLRRSRQNVLELILKRFVLIGLLVAGLGIAIDTYWHGQ-LI 199
                    A I+LP  +   +  R +     L            + I  + Y +G+  +
Sbjct: 184 GVFNRVTFPAFIFLPCLILFWKFYRVHWKSFSLLLLSFSFSSCLFVLIDTNIYNNGKGFV 243

Query: 200 VTPYEFLKYNIFNNIGSFYGSHPWHWYFSVGLPTVLGINTLPFIFGVMETVKKSEKYPVS 259
           +TP   LKYN+       +G HP + +  V LP +LG   L  IF           Y + 
Sbjct: 244 ITPLNNLKYNLNVQNLQVHGLHPRYTHLLVNLPQILGPVLLLAIF---------SGYKLD 294

Query: 260 KQLLITIFLTLVVLSAVEHKEFRFVSPLLPLCLYVITDALSRWSIRASSTMLWTTAL--V 317
           K     I   L+ LS  +H+E RF+ PL+PL +  +           SST++        
Sbjct: 295 KLSTYAIISGLLFLSFFQHQELRFLVPLVPLLVTNLNW------TPLSSTLVNKKIFKGT 348

Query: 318 ILVGNVMPAWYLSTVHQKGPIELMPKLREIAREYRDEREHQANILFLMPCHSTPYYSHIH 377
            L+ N++ A+ +   HQ G I+ +        +Y   R  Q  +      +S P + ++ 
Sbjct: 349 WLLFNIIMAFIMGISHQAGIIQFLG-------DYFHFRTEQMGVHIWWKTYSPPTWMYMS 401

Query: 378 QNVTMRFL 385
            N+T+  L
Sbjct: 402 NNLTVSSL 409
>ref|NP_014792.1| (NC_001147) Involved in glycosyl phosphatidyl inositol synthesis;
           most likely an alpha 1,2 mannosyltransferase utilized
           for addition of the fourth, side-branching mannose onto
           the GPI core structure.; Smp3p [Saccharomyces
           cerevisiae]
 sp|Q04174|SMP3_YEAST SMP3 PROTEIN
 pir||S67037 SMP3 protein - yeast (Saccharomyces cerevisiae)
 gb|AAC49635.1| (U55020) Smp3p [Saccharomyces cerevisiae]
 emb|CAA99355.1| (Z75057) ORF YOR149c [Saccharomyces cerevisiae]
          Length = 516

 Score =  238 bits (603), Expect = 2e-61
 Identities = 91/428 (21%), Positives = 161/428 (37%), Gaps = 69/428 (16%)

Query: 5   YVFLLILAVRLASVFVVQTYY-VPDEYWQSLEV-AHKLTFGYGYLTWEW--VQGIRSYVY 60
           Y + L L   +  +  +   Y  PDE++Q +E+ A +     G + WE+      RSY  
Sbjct: 4   YQWWLYLVYAIGLMLCLGPSYIHPDEHFQCIEILAMQFMKVKGTIPWEFKSKFAARSYGP 63

Query: 61  PLLIAGLYK---------------ILALLQLDSAHLL-----VVLPRI----RKWALF-- 94
            LL+ G                  IL  ++L +  +       ++P++    RK   F  
Sbjct: 64  LLLVYGPLFTILESFPEIQDNPALILYSMRLQNYVMYLLCYHFLIPKLIRDERKAVQFMQ 123

Query: 95  --LILVPWFWFYTGSRTLANTLEASLTTIALSYFP--------WYGESTAYLWPAAICCF 144
             L+L  +  +   + T +N++E       L+                   +    I  F
Sbjct: 124 KSLLLTSYVTWTYQTHTFSNSIETLALISTLTVMEDMVNEKNIQRSNFKNSVILGLIFSF 183

Query: 145 L----RPTAAVIWLPLSLYHLRRSRQNVLELILKRFVLIGLLVAGLGIAIDTYWHGQ-LI 199
                    A I+LP  +   +  R +     L            + I  + Y +G+  +
Sbjct: 184 GVFNRVTFPAFIFLPCLILFWKFYRVHWKSFSLLLLSFSFSSCLFVLIDTNIYNNGKGFV 243

Query: 200 VTPYEFLKYNIFNNIGSFYGSHPWHWYFSVGLPTVLGINTLPFIFGVMETVKKSEKYPVS 259
           +TP   LKYN+       +G HP + +  V LP ++G   L  IF           Y + 
Sbjct: 244 ITPLNNLKYNLNVQNLQVHGLHPRYTHLLVNLPQIVGPVLLLAIF---------SGYKLD 294

Query: 260 KQLLITIFLTLVVLSAVEHKEFRFVSPLLPLCLYVITDALSRWSIRASSTMLWTTAL--V 317
           K     I   L+ LS  +H+E RF+ PL+PL +  +           SST++        
Sbjct: 295 KLSTYAIISGLLFLSFFQHQELRFLVPLVPLLVTNLNW------TPLSSTLVNKKIFKGT 348

Query: 318 ILVGNVMPAWYLSTVHQKGPIELMPKLREIAREYRDEREHQANILFLMPCHSTPYYSHIH 377
            L+ N++ A+ +   HQ G I+ +        +Y   R  Q  +      +S P + ++ 
Sbjct: 349 WLLFNIIMAFIMGISHQAGIIQFLG-------DYFHFRTEQMGVHIWWKTYSPPTWMYMS 401

Query: 378 QNVTMRFL 385
            N+T+  L
Sbjct: 402 NNLTVSSL 409
>ref|NP_014427.1| (NC_001146) ExtraCellular Mutant; Ecm39p [Saccharomyces cerevisiae]
 sp|P53730|YN8I_YEAST Hypothetical 62.7 kDa protein in SEC12-SSK2 intergenic region
 pir||S63361 probable membrane protein YNR030w - yeast (Saccharomyces
           cerevisiae)
 emb|CAA96310.1| (Z71645) ORF YNR030w [Saccharomyces cerevisiae]
          Length = 551

 Score =  230 bits (583), Expect = 4e-59
 Identities = 65/406 (16%), Positives = 141/406 (34%), Gaps = 81/406 (19%)

Query: 5   YVFLLILAVRLASVFVVQTYYVPDEYWQSLEVAHKLT-------FGYGYLTWEWVQGIRS 57
           +  L  + + + S  ++Q  +   E   +++  H +          Y +L +  V   R+
Sbjct: 3   WSVLDTVLLTVISFHLIQAPFTKVEESFNIQAIHDILTYSVFDISQYDHLKFPGVVP-RT 61

Query: 58  YVYPLLIAGLYK----------------------ILALLQLDSAHLLVVLPRIRK----- 90
           +V  ++IA L +                      +  ++ L +    + L    +     
Sbjct: 62  FVGAVIIAMLSRPYLYLSSLIQTSRPTSIDVQLVVRGIVGLTNGLSFIYLKNCLQDMFDE 121

Query: 91  ----------------------WALFLILVPWFWFYTGSRTLAN-TLEASLTTIALSYFP 127
                                 W L  ++  +   +  +RTL N  +   LT +AL  + 
Sbjct: 122 ITEKKKEENEDKDIYIYDSAGTWFLLFLIGSFHLMFYSTRTLPNFVMTLPLTNVAL-GWV 180

Query: 128 WYGESTAYLWPAAICCFLRPTAA-VIWLPLSLYHLRRSRQNVLELILKRFVLIGLLVAGL 186
             G   A ++ +A+   +       +   ++L+          ++ L   +  G+   GL
Sbjct: 181 LLGRYNAAIFLSALVAIVFRLEVSALSAGIALFS-----VIFKKISLFDAIKFGIFGLGL 235

Query: 187 ----GIAIDTYWHGQLIVTPYEFLKYNIFNNIGSFYGSHPWHWYFSVGLPTVLGINTLPF 242
                I +D+Y+  +  +   +   +N+     S +G  P   YF+  L  +      P 
Sbjct: 236 GSAISITVDSYFWQEWCLPEVDGFLFNVVAGYASKWGVEPVTAYFTHYLRMM---FMPPT 292

Query: 243 IFGVMETVKKSEKYPVSKQLLITIFLTLVVLSAVEHKEFRFVSPLLPLCLYVITDALSR- 301
           +  +     K     +    L ++F  ++VLS   HKE+RF+   +P  + +     +  
Sbjct: 293 VLLLNYFGYKLAPAKLKIVSLASLF-HIIVLSFQPHKEWRFIIYAVPSIMLLGATGAAHL 351

Query: 302 WSIRASSTMLWTTALVILVGNVMPA-------WYLSTVHQKGPIEL 340
           W       +     L IL  ++M +        Y+S ++  G   L
Sbjct: 352 WENMKVKKITNVLCLAILPLSIMTSFFISMAFLYISRMNYPGGEAL 397
>ref|NP_173134.1| (NM_101551) Ser/Thr protein kinase, putative [Arabidopsis thaliana]
          Length = 919

 Score =  228 bits (576), Expect = 3e-58
 Identities = 60/321 (18%), Positives = 114/321 (34%), Gaps = 39/321 (12%)

Query: 7   FLLILAVRLASVFVVQTYYVPDEYWQSLEVAHKLTFGYGYLTWEWV--QGIRSYVYPLLI 64
           F+ +  +R  S       +  DE +   E  H + +  G+ TWE+     +RSY+Y L  
Sbjct: 399 FIALCYLRYMSA-TSNIIHDCDEVFNYWEPLHYILYKSGFQTWEYSSNFALRSYLYILFH 457

Query: 65  A----------------GLYKILALLQLDSAHLLV---------VLPRIRKWALF-LILV 98
                              Y +   L L SA                RI  +A+  L L 
Sbjct: 458 ELAGRPASWWFGDDKVRVFYAVRLFLGLVSAVSDTVLVVALSRKYGKRIATYAVAMLCLT 517

Query: 99  PWFWFYTGSRTLANTLEASLTTI--ALSYFPWYGESTAYLWPAAICCFLRPTAAVIWLPL 156
               F+  +  L ++      ++   L  F  Y  + A            P + + +LP+
Sbjct: 518 SGC-FFASTSFLPSSFSMYAISLSSGLLLFEKYAMAVAVSVV--GVILGWPFSILAFLPV 574

Query: 157 SLYHLRRSRQNVLELILKRFVLIGLLVAGLGIAIDTYWHGQLIVTPYEFLKYNIFNNI-G 215
            +Y L +      +       +  + + G+ + +D Y++ +   +    L YN+      
Sbjct: 575 VIYSLVKR----FKQAFIAGAVTTIFLLGVSLLVDYYYYKRWTSSVLNLLIYNVLGGGES 630

Query: 216 SFYGSHPWHWYFSVGLPTVLGINTLPFIFGVMETVKKSEKYPVSKQLLITIFLTLVVLSA 275
             YG+    +Y   G         L  +F  +  V + +       ++  +++ L  +S 
Sbjct: 631 HLYGTEGALFYIRNGFNNFNFCFILAMLFVAIYPVIRRKYDRALLVVISPMYIWLAFMSL 690

Query: 276 VEHKEFRFVSPLLPLCLYVIT 296
             HKE RF+ P+ PL     +
Sbjct: 691 QPHKEERFLYPIYPLICVSAS 711
>ref|NP_496282.1| (NM_063881) C14A4.3.p [Caenorhabditis elegans]
 sp|P54002|YTH3_CAEEL Hypothetical 75.5 kDa protein C14A4.3 in chromosome II
 pir||T19245 hypothetical protein C14A4.3 - Caenorhabditis elegans
 emb|CAA90107.1| (Z49909) weak similarity with a B. Flavum translocation protein
           (Swiss Prot accession number P38376)~cDNA EST yk549e12.3
           comes from this gene~cDNA EST yk618d6.3 comes from this
           gene~cDNA EST yk549e12.5 comes from this gene~cDNA EST
           yk618d6.5 comes from>
          Length = 653

 Score =  225 bits (570), Expect = 1e-57
 Identities = 81/371 (21%), Positives = 140/371 (36%), Gaps = 51/371 (13%)

Query: 2   KLIYVFLLILAVRLASVFVVQTYYVPDEYWQSLEVAHKLTFGYGYLTWEW--VQGIRSYV 59
               VF ++L++R++           DE +   E  H   +G G+ TWE+  V  IRSY 
Sbjct: 52  SFGSVFKMLLSIRISGAIW-GIINDCDEVYNYWEPLHLFLYGEGFQTWEYSPVYAIRSYF 110

Query: 60  YPLLIAGLYKILALLQLDSAHLLVVLPRIRKWALFLILVPWFWF---------------- 103
           Y  L      + A L  D+  ++  L R+    LF +L  ++ F                
Sbjct: 111 YIYLHYIPASLFANLFGDTKIVVFTLIRL-TIGLFCLLGEYYAFDAICKKINIATGRFFI 169

Query: 104 ----YTGSRTLANTLEASLTTIALSYFPWYGESTAYLWPAAICC------FLRPTAAVIW 153
               ++    LA+T     +      F   G      W A I C         P +AV+ 
Sbjct: 170 LFSIFSSGMFLASTAFVPSSFCMAITFYILGAYLNENWTAGIFCVAFSTMVGWPFSAVLG 229

Query: 154 LPLSLYHLRRSRQNVLELILKRFVLIGLLVAGLGIAIDTYWHGQLIVTPYEFLKYNIFNN 213
           LP+    L    + +    +   ++IGL + G+ +  D+++ G+ ++ P     YN+ + 
Sbjct: 230 LPIVADMLLL--KGLRIRFILTSLVIGLCIGGVQVITDSHYFGKTVLAPLNIFLYNVVSG 287

Query: 214 IG-SFYGSHPWHWYFSV--------------GLPTVLGINTLPFIFGVMETVKKSEKYPV 258
            G S YG  P  +Y                 G P  L   T  ++      V   +++  
Sbjct: 288 PGPSLYGEEPLSFYIKNLFNNWNIVIFAAPFGFPLSLAYFTKVWMS-QDRNVALYQRFAP 346

Query: 259 SKQLLITIFLTLVVLSAVEHKEFRFVSPLLPLCLYVITDALS---RWSIRASSTMLWTTA 315
              L +T    L++  +  HKE RF+ P+ P   +    AL    R  ++        + 
Sbjct: 347 IILLAVTTAAWLLIFGSQAHKEERFLFPIYPFIAFFAALALDATNRLCLKKLGMDNILSI 406

Query: 316 LVILVGNVMPA 326
           L IL   ++ A
Sbjct: 407 LFILCFAILSA 417
>gb|AAF99843.1|AC051629_10 (AC051629) Hypothetical protein [Arabidopsis thaliana]
          Length = 570

 Score =  216 bits (545), Expect = 9e-55
 Identities = 60/321 (18%), Positives = 114/321 (34%), Gaps = 39/321 (12%)

Query: 7   FLLILAVRLASVFVVQTYYVPDEYWQSLEVAHKLTFGYGYLTWEWV--QGIRSYVYPLLI 64
           F+ +  +R  S       +  DE +   E  H + +  G+ TWE+     +RSY+Y L  
Sbjct: 50  FIALCYLRYMSA-TSNIIHDCDEVFNYWEPLHYILYKSGFQTWEYSSNFALRSYLYILFH 108

Query: 65  A----------------GLYKILALLQLDSAHLLV---------VLPRIRKWALF-LILV 98
                              Y +   L L SA                RI  +A+  L L 
Sbjct: 109 ELAGRPASWWFGDDKVRVFYAVRLFLGLVSAVSDTVLVVALSRKYGKRIATYAVAMLCLT 168

Query: 99  PWFWFYTGSRTLANTLEASLTTI--ALSYFPWYGESTAYLWPAAICCFLRPTAAVIWLPL 156
               F+  +  L ++      ++   L  F  Y  + A            P + + +LP+
Sbjct: 169 SGC-FFASTSFLPSSFSMYAISLSSGLLLFEKYAMAVAVSVV--GVILGWPFSILAFLPV 225

Query: 157 SLYHLRRSRQNVLELILKRFVLIGLLVAGLGIAIDTYWHGQLIVTPYEFLKYNIFNNI-G 215
            +Y L +      +       +  + + G+ + +D Y++ +   +    L YN+      
Sbjct: 226 VIYSLVKR----FKQAFIAGAVTTIFLLGVSLLVDYYYYKRWTSSVLNLLIYNVLGGGES 281

Query: 216 SFYGSHPWHWYFSVGLPTVLGINTLPFIFGVMETVKKSEKYPVSKQLLITIFLTLVVLSA 275
             YG+    +Y   G         L  +F  +  V + +       ++  +++ L  +S 
Sbjct: 282 HLYGTEGALFYIRNGFNNFNFCFILAMLFVAIYPVIRRKYDRALLVVISPMYIWLAFMSL 341

Query: 276 VEHKEFRFVSPLLPLCLYVIT 296
             HKE RF+ P+ PL     +
Sbjct: 342 QPHKEERFLYPIYPLICVSAS 362
>emb|CAA42931.1| (X60381) ORF2 [Saccharomyces cerevisiae]
          Length = 278

 Score =  215 bits (544), Expect = 1e-54
 Identities = 74/275 (26%), Positives = 121/275 (43%), Gaps = 45/275 (16%)

Query: 230 GLPTVLGINTLPFIFGVMETVKKSEK----YPVSKQLLITIFLTLVVLSAVEHKEFRFVS 285
            LP VLG +   F FG+   + K            Q+ +TI L L+V S + HKEFRF+ 
Sbjct: 1   ALPIVLGASIPAFAFGLFFPLSKRSFPKKYLNPFFQVKLTILLNLLVYSTLPHKEFRFIF 60

Query: 286 PLLPLCLYVITDALSRW--SIRASSTMLWTTALVILVGNVMPAWYLSTVHQKGPIELMPK 343
           PL PL + + +  L R         + L +   ++   +V  A  L T H+ G IE+M  
Sbjct: 61  PLQPLFILISSFGLLRLDRDYWKRLSGLKSLLWLVPFVSVFIALLLDTFHESGSIEVM-- 118

Query: 344 LREIAREYRDEREHQANILFLMPCHSTPYYSHIHQNVTMRF--LTCEPNLE--------- 392
                 ++  E     ++ F+MPCHSTP  S++H++       +TC P L          
Sbjct: 119 ------KFLHEEPEIDSLGFIMPCHSTPGQSYLHRSDIQDLWSITCNPPLHLLGDPEAYS 172

Query: 393 KKEQYKDEADRFFEDPVHWINSHIPMHPLT-----------ALPTHVVLFDPLAENI--- 438
           K E Y DE+D  ++D   +I  + P                  PT++V+F+ +       
Sbjct: 173 KLETYMDESDHLYDDISAFIYKNFPPPFRKDLRSPGKTYSHEWPTYLVVFEHMENAFLKD 232

Query: 439 ----SVFLRNYRLLHRIEHAENRQSRTGRSILVYQ 469
               S ++   R  + + H ++R  R+G  I+ Y+
Sbjct: 233 FLKDSSYIEYNRFFNSLAHWDSR--RSGDIIIYYK 265
>ref|NP_014180.1| (NC_001146) catalyzes the transfer of mannose from Dol-P-Man to
           lipid-linked oligosaccharides; Alg9p [Saccharomyces
           cerevisiae]
 sp|P53868|ALG9_YEAST Probable mannosyltransferase ALG9
 pir||S63177 mannosyl transferase (EC 2.4.1.-) - yeast (Saccharomyces
           cerevisiae)
 emb|CAA96122.1| (Z71495) ORF YNL219c [Saccharomyces cerevisiae]
 emb|CAA65277.1| (X96417) putative mannosyltransferase [Saccharomyces cerevisiae]
          Length = 555

 Score =  214 bits (540), Expect = 4e-54
 Identities = 78/366 (21%), Positives = 126/366 (34%), Gaps = 55/366 (15%)

Query: 4   IYVFLLILAVRLASVFVVQTYYVPDEYWQSLEVAHKLTFGYGYLTWEWV--QGIRSYVYP 61
           I + LL+   R+            DE +   E  + L  G+G  TWE+     IRS+ + 
Sbjct: 8   ISLLLLLFLTRVYIQPTFSLISDCDETFNYWEPLNLLVRGFGKQTWEYSPEYSIRSWAFL 67

Query: 62  LLIA-GLYKI---------------LALLQLDSAHLLVVLPRIRKWALFLILVPWF---- 101
           L     LY +                A L   S  +   L R    +L L +   +    
Sbjct: 68  LPFYCILYPVNKFTDLESHWNFFITRACLGFFSFIMEFKLHREIAGSLALQIANIWIIFQ 127

Query: 102 -----WFYTGSRTLANTLEASLTTIALSYFPWY---------GESTAYLWPAAICCFLRP 147
                WF+     L + +   L   A  +   Y          +S AY + A       P
Sbjct: 128 LFNPGWFHASVELLPSAVAMLLYVGATRHSLRYLSTGSTSNFTKSLAYNFLA--SILGWP 185

Query: 148 TAAVIWLPLSLYHLRRSRQNVLELILKRFVLIGLLVAGLGIAIDTYWHGQLIVTPYEFLK 207
              ++ LPL L++L   R            LI  L A   I  D+ ++G+L    +  L 
Sbjct: 186 FVLILSLPLCLHYLFNHRIISTIRTAFDCCLIFSLTAFAVIVTDSIFYGKLAPVSWNILF 245

Query: 208 YNIFN----NIGSFYGSHPWHWYFSVGLPTVLGINTLPFIFGVMETVKKSEKYPVSKQLL 263
           YN+ N    +  + +G  PW++Y    L        +  I G+               L 
Sbjct: 246 YNVINASEESGPNIFGVEPWYYYPLNLLLNFPLPVLVLAILGIFHLRLW--------PLW 297

Query: 264 ITIFLTLVVLSAVEHKEFRFVSPLLPLCLYVITDAL---SRWSIRA--SSTMLWTTALVI 318
            ++F  + V +   HKE RF+ P+  L     + A         R       +  + L+I
Sbjct: 298 ASLFTWIAVFTQQPHKEERFLYPIYGLITLSASIAFYKVLNLFNRKPILKKGIKLSVLLI 357

Query: 319 LVGNVM 324
           + G  M
Sbjct: 358 VAGQAM 363
>ref|NP_079439.1| (NM_025163) hypothetical protein FLJ12768 [Homo sapiens]
 dbj|BAB14263.1| (AK022830) unnamed protein product [Homo sapiens]
          Length = 579

 Score =  210 bits (532), Expect = 4e-53
 Identities = 85/449 (18%), Positives = 151/449 (32%), Gaps = 91/449 (20%)

Query: 1   MKLIYVFLLILAVRLASVFVVQTYY-VPDEYWQSLEV-AHKLTFGYGYLTWEW--VQGIR 56
           +++++  L +L  R+    + QT Y  PDE++QS EV A  +        WE+      R
Sbjct: 34  VRVLWGGLSLL--RVLWCLLPQTGYVHPDEFFQSPEVMAEDILGVQAARPWEFYPSSSCR 91

Query: 57  SYVYPLLIAGLYK--------ILALLQLDSAHLLVVLPRIRK------------------ 90
           S ++PLLI+G           +     L S + L+V PR+                    
Sbjct: 92  SVLFPLLISGSTFWLLRLWEELGPWPGLVSGYALLVGPRLLLTALSFALDGAVYHLAPPM 151

Query: 91  -----WALFLILVPWFWFYTGSRTLANTLEASLTTIALSYF----------------PWY 129
                 AL L+   +      +RT +NT+E  L T  L                   P +
Sbjct: 152 GADRWNALALLSGSYVTLVFYTRTFSNTIEGLLFTWLLVLVSSHVTWGPTRKEPAPGPRW 211

Query: 130 GESTAYLWPAAICCFLRPTAAVIWLPLSLYH----LRRSRQNVLELILKRFVLIGLLVAG 185
                    AA   F RPT     +                  L       +    L A 
Sbjct: 212 RSWLLGGIVAAGF-FNRPTFLAFAVVPLYLWGTRGATNPGLKSLTREALVLLPGATLTAA 270

Query: 186 LGIAIDTYWH------GQLIVTPYEFLKYNIFNNIGSFYGSHPWHWYF-SVGLPTVLGIN 238
           + +A D+++         L++TP  FL YN+     + +G+H    +    G      ++
Sbjct: 271 VFVATDSWYFSSPATSRNLVLTPVNFLHYNLNPQNLARHGTHARLTHLAVNGFLLFGVLH 330

Query: 239 T---------------LPFIFGVMETVKKSEKYPVSKQLLITI-FLTLVVLSAVEHKEFR 282
                                G++  +         +  L+ + F+ L +LSA  H+E R
Sbjct: 331 AQALQAAWQQLQVGLQASAQMGLLRALGARSLLSSPRSYLLLLYFMPLALLSAFSHQEAR 390

Query: 283 FVSPLLPLCLYVITDALSRWSIRASSTMLWTTALVILVGNVMPAWYLSTVHQKGPIELMP 342
           F+ PLL   + + +          +  + W     +++ N + A     +HQ G +  + 
Sbjct: 391 FLIPLLVPLVLLCS--------PQTQPVPWKG--TVVLFNALGALLFGCLHQGGLVPGLE 440

Query: 343 KLREIAREYRDEREHQANILFLMPCHSTP 371
            L ++              L     +  P
Sbjct: 441 YLEQVVHAPVLPSTPTHYTLLFTHTYMPP 469
>gb|AAD53921.1|AF179611_5 (AF179611) phosphatidylinositol glycan homolog [Zymomonas mobilis]
          Length = 509

 Score =  177 bits (445), Expect = 6e-43
 Identities = 75/427 (17%), Positives = 143/427 (32%), Gaps = 67/427 (15%)

Query: 1   MKLIYVFLLILAVRLASVFVVQTYYVPDEYWQSLEVAHKLTFGYGYLTWEWVQGIRSYVY 60
           + ++ + LL L +R+ ++F +  YY PDE +Q LE AH+L FGY  + WE+  G+R  + 
Sbjct: 21  LTVLLITLLALCLRMTAIFPIG-YYHPDEIFQYLEQAHRLAFGYSVIPWEYRYGMRGGLV 79

Query: 61  PLLIAGLYKILALLQLDSAHLLVVLPRIRKWALFLILVPWFWFYTGSR---TLANTLEAS 117
           P+L+A   K+  ++   S  L  VLP        L L   +  Y   R        L   
Sbjct: 80  PVLLAAAMKMGDIMNTQS-FLYWVLPH--AITALLSLGVIWSAYKLGRLHSFFTGCLAMF 136

Query: 118 LTT----IALSYFPWYGESTAY--LWPAA--ICCFLRPTAAVIWLPLSLYHLRRSRQNVL 169
           +      I L       ES ++    PAA  +    +  +++I     +      R    
Sbjct: 137 VAATWYEIVLFAAHPLSESLSFAAFMPAAYYLIAEEKKKSSLILSGFLMGLSALLR---- 192

Query: 170 ELILKRFVLIGLLVAGLGIAIDTYWHGQLIVTPYEFLKYNIFNNIGSFY-GSHPWHWYFS 228
                +++   L +    + I+    G  I+     +     +++   + G +P  W F 
Sbjct: 193 ----FQYIPSILFITLFTLRINVRQWGYFILGGLGAV---FISSLSDIFIGEYPLLWLFK 245

Query: 229 V-----GLPTVLGINTLPFIFGVMETVKKSEKYPVSKQ------------LLITIFLTLV 271
                          T P      +     + + +               L  T  + L+
Sbjct: 246 NIQQNLIFHRAEDYGTAPIYSYFFDIWTNWKWFSLILPIPILVAAYRYPALFGTALVNLI 305

Query: 272 VLSAVEHKEFRFVSPLLPLCLYVITDALSRW-------SIRASSTMLWTTALVILVGNVM 324
               V HKE+RF+     + + +     +                +    A         
Sbjct: 306 FHMLVSHKEYRFIFLSSGIFIILAAIGSALLIEKATINFTPLHKKLAQIAAFTAWGACSF 365

Query: 325 PAWYLSTVH---QKGPIELMPK---LREIAREYRDEREHQANILFLMPCHSTPYYSHIHQ 378
                +  H    +G ++   K   L  +      +      I +      +  YS +H+
Sbjct: 366 LCSTGNISHWYQYRGVLQAEMKARSLSNLCGLTLYQ------IDYW----ESGGYSLLHR 415

Query: 379 NVTMRFL 385
            + +  L
Sbjct: 416 PIPIYSL 422
>ref|XP_016392.3| (XM_016392) hypothetical protein FLJ12768 [Homo sapiens]
          Length = 457

 Score =  171 bits (430), Expect = 3e-41
 Identities = 63/359 (17%), Positives = 110/359 (30%), Gaps = 69/359 (19%)

Query: 70  ILALLQLDS----AHLLVVLPRIRKW----------ALFLILVPWFWFYTGSRTLANTLE 115
           +     LDS      LL   P    W          AL L+   +      +RT +NT+E
Sbjct: 1   MRCWWGLDSSSLPFPLLWTGP-CTTWPPAMGADRWNALALLSGSYVTLVFYTRTFSNTIE 59

Query: 116 ASLTTIALSYF----------------PWYGESTAYLWPAAICCFLRPTAAVIWLPLSLY 159
             L T  L                   P +         AA   F RPT     +     
Sbjct: 60  GLLFTWLLVLVSSHVTWGPTRKEPAPGPRWRSWLLGGIVAAGF-FNRPTFLAFAVVPLYL 118

Query: 160 H----LRRSRQNVLELILKRFVLIGLLVAGLGIAIDTYWH------GQLIVTPYEFLKYN 209
                        L       +    L A + +A D+++         L++TP  FL YN
Sbjct: 119 WGTRGATNPGLKSLTREALVLLPGATLTAAVFVATDSWYFSSPATSRNLVLTPVNFLHYN 178

Query: 210 IFNNIGSFYGSHPWHWYF-SVGLPTVLGINTLPFIF---------------GVMETVKKS 253
           +     + +G+H    +    G      ++                     G++  +   
Sbjct: 179 LNPQNLARHGTHARLTHLAVNGFLLFGVLHAQALQAAWQRLQVGLQASAQMGLLRALGAR 238

Query: 254 EKYPVSKQLLITI-FLTLVVLSAVEHKEFRFVSPLLPLCLYVITDALSRWSIRASSTMLW 312
                 +  L+ + F+ L +LSA  H+E RF+ PLL   + + +          +  + W
Sbjct: 239 SLLSSPRSYLLLLYFMPLALLSAFSHQEARFLIPLLVPLVLLCS--------PQTQPVPW 290

Query: 313 TTALVILVGNVMPAWYLSTVHQKGPIELMPKLREIAREYRDEREHQANILFLMPCHSTP 371
                + + N + A     +HQ G +  +  L ++              L     +  P
Sbjct: 291 KG--TVALFNALGALLFGCLHQGGLVPGLEYLEQVVHAPVLPSTPTHYTLLFTHTYMPP 347
>pir||T16945 hypothetical protein T27F7.3 - Caenorhabditis elegans
          Length = 283

 Score =  149 bits (373), Expect = 2e-34
 Identities = 44/165 (26%), Positives = 73/165 (43%), Gaps = 19/165 (11%)

Query: 206 LKYNIFNNIGSFYGSHPWHWYFSVGLPTVLGINTLPFIFGVMETVKKSEKYPVSKQLLIT 265
           + +N+     + +G HPW+WY   G+P VL +  +P I G++          + +  L+ 
Sbjct: 129 IAFNVVQGGSALFGVHPWYWYIVSGIPAVLTVQMIPIIVGLLGP-------NIFRPSLLP 181

Query: 266 IFLT---LVVLSAVEHKEFRFVSPLLPLCLYVITDALSRWSIRASSTMLWTTALVILVGN 322
            F T   ++V S + HKE RF+ P++PL       A         S M    A+     N
Sbjct: 182 FFATITYIIVHSLLPHKEQRFLLPIIPLLCIYAGGAFQNLKKWRGSAMAVMIAI-----N 236

Query: 323 VMPAWYLSTVHQK----GPIELMPKLREIAREYRDEREHQANILF 363
           +  A + S  HQK    G I   P+  E+ +   D+R+   + L 
Sbjct: 237 IGIALFTSRYHQKHSCNGTIVEHPEYGEVIQLTGDQRDKVKDFLI 281
 Score = 79.3 bits (194), Expect = 2e-13
 Identities = 27/57 (47%), Positives = 41/57 (71%)

Query: 10  ILAVRLASVFVVQTYYVPDEYWQSLEVAHKLTFGYGYLTWEWVQGIRSYVYPLLIAG 66
           ++  R  SV++V +++VPDE +QS EVAH L +G G+L+WEW   +RS+ +P LIA 
Sbjct: 75  LVVFRCISVYLVASWFVPDEVYQSAEVAHHLVYGTGHLSWEWRHSLRSFFHPALIAF 131
>dbj|BAA87150.1| (AB027846) Hypothetical protein [Schizosaccharomyces pombe]
          Length = 197

 Score =  149 bits (373), Expect = 2e-34
 Identities = 39/204 (19%), Positives = 70/204 (34%), Gaps = 7/204 (3%)

Query: 85  LPRIRKWALFLILVPWFWFYTGSRTLANTLEASLTTIALSYFPWYGESTAYLWPAAICCF 144
                   +      +   Y  SR L+N      T  +LS           +        
Sbjct: 1   GTLSGALFILFSCAQFHLVYYMSRPLSNIFGLIATNHSLSL-LLKNNYYGSISILVFAAA 59

Query: 145 LRPTAAVIWLPLSLYHLRRSRQNVLELILKRFVLIGLLVAGLGIAIDTYWHGQLIVTPYE 204
           +  +   + L   +  L   R+  L  +L   +   L   G    ID+Y+ G       E
Sbjct: 60  IVRSEIALLLMCLILPLLLQRRITLSKLLLVGISSSLAAVGASFLIDSYFWGAWCWPELE 119

Query: 205 FLKYNIFNNIGSFYGSHPWHWYFSVGLPTVLGINTLPFIFGVMETVKKSEKYPVSKQLLI 264
              +N+     S +G+ P+++YF       L   TL F+      +K       ++ L+ 
Sbjct: 120 AFLFNVVEGKSSDWGTSPFYYYFVRLPWLFLNPTTLLFLLISFVYIK------PARLLIY 173

Query: 265 TIFLTLVVLSAVEHKEFRFVSPLL 288
                + V S + HKE+RF+   +
Sbjct: 174 VPLFFIFVYSFLGHKEWRFIIYSI 197
>gb|AAH21379.1|AAH21379 (BC021379) Similar to hypothetical protein MGC3136 [Mus musculus]
          Length = 385

 Score =  147 bits (369), Expect = 4e-34
 Identities = 42/212 (19%), Positives = 82/212 (37%), Gaps = 36/212 (16%)

Query: 8   LLILAVRLASVFVVQTYYVPDEYWQSLEVAHKLTF------GYGYLTWEWVQGIRSYVYP 61
           LL L V +A++ +V   Y   E   +L+  H L +       Y +  +  V   R+++ P
Sbjct: 14  LLGLLVTVATIHLVICPYTKVEESFNLQATHDLLYHQLDIDKYDHHEFPGVVP-RTFLGP 72

Query: 62  LLIAGLYK----ILALLQLDSAH----------------LLVVLPRIRKWALFLILVPWF 101
           L+IA        +L+LL++   +                L  +   +R+     + V + 
Sbjct: 73  LVIAAFSSPVVYVLSLLEVSKFYSQLIVRGVLGLGVISGLWTLQKEVRQQFGATVAVMFC 132

Query: 102 W--------FYTGSRTLANTLEASLTTIALSYFPWYGESTAYLWPAAICCFLRPTAAVIW 153
           W         +  +RTL N L  ++   AL+ +        ++W +A           + 
Sbjct: 133 WISATQFHLMFYCTRTLPNVLALAVVLPALTAW-LQRRWALFVWLSAFVIIGFRAELAML 191

Query: 154 LPLSLYHLRRSRQNVLELILKRFVLIGLLVAG 185
           L ++L      R+  +  +L+  +  GLL  G
Sbjct: 192 LGIALLLTLYQRRLTVARVLRHAIPAGLLCLG 223
 Score = 47.7 bits (113), Expect = 5e-04
 Identities = 28/181 (15%), Positives = 50/181 (27%), Gaps = 32/181 (17%)

Query: 225 WYFSVGLP--TVLGINTLPFIFGVMETVKKSEKYPVSKQLLITIFLTLVVLSAVEHKE-- 280
           +Y +  LP    L +        +               ++I     L +L  +      
Sbjct: 143 FYCTRTLPNVLALAVVLPALTAWLQRRWALFVWLSAF--VIIGFRAELAMLLGIALLLTL 200

Query: 281 ----------FRFVSPLLPLCL-----YVITDALSRWSIRASSTMLWTTALVILVGNVMP 325
                      R   P   LCL      V       W       ML T  +++ V     
Sbjct: 201 YQRRLTVARVLRHAIPAGLLCLGKLASLVCLLNKKSWPY-KVRAMLVTGHILVNVAYTAT 259

Query: 326 AWYLSTVHQKGPIELMPKLREIAREYRDEREHQANI--LFLMPCHSTPYYSHIHQNVTMR 383
           + Y+S  +  G +  M +L E+          Q ++     +    T     +  N   R
Sbjct: 260 SLYVSHFNYPGGV-AMQQLHELV-------PPQTDVLLHIDVAAAQTGVSRFLQVNDDWR 311

Query: 384 F 384
           +
Sbjct: 312 Y 312
>ref|NP_494918.1| (NM_062517) T27F7.3a.p [Caenorhabditis elegans]
 gb|AAK39304.1| (U58762) weakly similar to protein translation factor SUI1 family
           [Caenorhabditis elegans]
          Length = 232

 Score =  142 bits (355), Expect = 2e-32
 Identities = 44/165 (26%), Positives = 73/165 (43%), Gaps = 19/165 (11%)

Query: 206 LKYNIFNNIGSFYGSHPWHWYFSVGLPTVLGINTLPFIFGVMETVKKSEKYPVSKQLLIT 265
           + +N+     + +G HPW+WY   G+P VL +  +P I G++          + +  L+ 
Sbjct: 65  IAFNVVQGGSALFGVHPWYWYIVSGIPAVLTVQMIPIIVGLLGP-------NIFRPSLLP 117

Query: 266 IFLT---LVVLSAVEHKEFRFVSPLLPLCLYVITDALSRWSIRASSTMLWTTALVILVGN 322
            F T   ++V S + HKE RF+ P++PL       A         S M    A+     N
Sbjct: 118 FFATITYIIVHSLLPHKEQRFLLPIIPLLCIYAGGAFQNLKKWRGSAMAVMIAI-----N 172

Query: 323 VMPAWYLSTVHQK----GPIELMPKLREIAREYRDEREHQANILF 363
           +  A + S  HQK    G I   P+  E+ +   D+R+   + L 
Sbjct: 173 IGIALFTSRYHQKHSCNGTIVEHPEYGEVIQLTGDQRDKVKDFLI 217
 Score = 76.2 bits (186), Expect = 1e-12
 Identities = 27/57 (47%), Positives = 41/57 (71%)

Query: 10 ILAVRLASVFVVQTYYVPDEYWQSLEVAHKLTFGYGYLTWEWVQGIRSYVYPLLIAG 66
          ++  R  SV++V +++VPDE +QS EVAH L +G G+L+WEW   +RS+ +P LIA 
Sbjct: 11 LVVFRCISVYLVASWFVPDEVYQSAEVAHHLVYGTGHLSWEWRHSLRSFFHPALIAF 67
>gb|AAF47201.1| (AE003464) CG3419 gene product [Drosophila melanogaster]
          Length = 830

 Score =  128 bits (320), Expect = 2e-28
 Identities = 49/263 (18%), Positives = 83/263 (30%), Gaps = 50/263 (19%)

Query: 135 YLWPAAICCFLRPTAAVIWLPLSLYHLRR---SRQNVLELILKRFVLI---GLLVAGLGI 188
                A   F RPT  +   P+  + L R   +R         R  L     L    L I
Sbjct: 229 STICVAGV-FNRPTFLLFGAPMVFFWLLRGMGTRSITFRDFNLRIALFCLCALPALVLFI 287

Query: 189 AIDTYWHGQ---------------LIVTPYEFLKYNIFNNIGSFYGSHPWHWYFSVGLP- 232
             D+ ++                  + TP+ F+K N+ +   + +G HP + +  V +P 
Sbjct: 288 FCDSLYYQHLTLGELHMMHLSIDNFVFTPWNFIKANLDSAQTASHGVHPCYVHLMVNMPM 347

Query: 233 ----TVLGINTLPFIFGVMETVKKSEKYPVSK----QLLITIFLTLVVLSAVEHKEFRFV 284
                 L          +     + +  P  +     +   IF+ L  LS + H+E RF+
Sbjct: 348 LFNVLALASLGAFAQLLLRFFRAEYQVLPRFQSIVSLMSGAIFVPLFFLSLINHQEPRFL 407

Query: 285 SPL-LPLCLY--------VITDA-------LSRWSIRASSTMLWTTALV---ILVGNVMP 325
            P+  PL L                     L R       +   +   +     V NV  
Sbjct: 408 LPVTFPLILLHAPKLITGFSAKYPFQKDHPLLRLFYDKLLSSKASGPYLLKIWYVSNVAL 467

Query: 326 AWYLSTVHQKGPIELMPKLREIA 348
             +   +HQ G   L   +  + 
Sbjct: 468 TLFFGFIHQAGVYPLAADISHVI 490
 Score = 36.4 bits (84), Expect = 1.2
 Identities = 40/158 (25%), Positives = 62/158 (38%), Gaps = 38/158 (24%)

Query: 4   IYVFLLILAVRLASVFVVQTYY-VPDEYWQSLEVAHKLTFGYGY-LTWEW--VQGIRS-Y 58
           +  +    AVRL  VFV Q  Y  PDE++QS+EV     F   +  TWE+     +RS  
Sbjct: 17  LSTYFCFAAVRLLLVFVPQLGYVHPDEFFQSVEVMTGDHFRLEHTRTWEFNNSLPVRSIV 76

Query: 59  VYPLLIAGLYK--------ILAL--LQLDSAHLLVVLPR-----------------IRKW 91
           +   L+   +         + A   L+L   +  VV PR                  R +
Sbjct: 77  LPFALLRIPWSFYEFVAECLKAWWQLELLGTYAYVVFPRLIYTLISFSNDYCLFRICRLY 136

Query: 92  A------LFLILVPWFWFYTGSRTLANTLEASLTTIAL 123
                  L  +   W     G+RT +N+LE ++ +  L
Sbjct: 137 GLRFEIRLLAMGSSWILLVFGTRTFSNSLEMAMCSWLL 174
>dbj|BAB21931.1| (AB055306) hypothetical protein [Macaca fascicularis]
          Length = 198

 Score =  102 bits (253), Expect = 2e-20
 Identities = 33/134 (24%), Positives = 47/134 (34%), Gaps = 31/134 (23%)

Query: 7   FLLILAVRLASVFVVQTYYVPDEYWQSLEVAHKLTFGYGYLTWEWV--QGIRSYVYPLLI 64
           F  +L+ RL +  +       DE +   E  H L +G G+ TWE+     IRSY Y LL 
Sbjct: 62  FKCLLSARLCAALLSNISD-CDETFNYWEPTHYLIYGEGFQTWEYSPAYAIRSYAYLLLH 120

Query: 65  AG----------------LYKILALLQLDSAH--LLVVLPRIRKWAL--------FLILV 98
           A                  Y +  LL   S    L       +K+ L        FL+L 
Sbjct: 121 AWPAAFHARILQTNKILVFYFLRCLLAFVSCICELYFYKAVCKKFGLHVSRMMLAFLVLS 180

Query: 99  PWFWFYTGSRTLAN 112
                +  S    +
Sbjct: 181 TGM--FCSSSVYPS 192
>emb|CAC02000.2| (AL390114) possible hypothetical 66.3 Kd protein c1834.05 in
           chromosome I precursor [Leishmania major]
          Length = 822

 Score = 83.6 bits (205), Expect = 8e-15
 Identities = 25/162 (15%), Positives = 43/162 (26%), Gaps = 32/162 (19%)

Query: 7   FLLILAVRLASVFVVQTYYVPDEYWQSLEVAHKLTFGYGYLTWE--WVQGIRSYVYPLLI 64
           FLL+      +   +      DE +  +E  H L +G G  TWE      +RS+++  + 
Sbjct: 15  FLLLSLTHYFASSFLPISD-CDETFNFIEPIHYLLYGSGKQTWEVCSRFALRSWLFLWIH 73

Query: 65  AGLYK-ILALLQLDSAHLLVVLPRIRKWALFLILVPWFWFYT------------------ 105
           A     I     L S  +   L           L   F+  +                  
Sbjct: 74  AWPVVLIRGAASLSSVRVYFYLR--MLNGCAAALAELFFVCSVWFTLSGKAAAVALLLLL 131

Query: 106 --------GSRTLANTLEASLTTIALSYFPWYGESTAYLWPA 139
                       L  +       + L  +      T+     
Sbjct: 132 ANYPIQHAAVSVLPTSFAMMCNFVVLGSWLRTQSWTSSSALL 173
 Score = 70.7 bits (172), Expect = 6e-11
 Identities = 14/65 (21%), Positives = 21/65 (31%)

Query: 241 PFIFGVMETVKKSEKYPVSKQLLITIFLTLVVLSAVEHKEFRFVSPLLPLCLYVITDALS 300
           P        V            ++  F+  +   ++ HKE RF+SP  P  L   T  L 
Sbjct: 417 PLPAATTAAVGSRLSRERELLHIMPFFVWFLFWMSIAHKEERFMSPAYPFMLLAATRTLC 476

Query: 301 RWSIR 305
                
Sbjct: 477 LMFFP 481
 Score = 51.3 bits (122), Expect = 4e-05
 Identities = 20/108 (18%), Positives = 40/108 (36%), Gaps = 9/108 (8%)

Query: 130 GESTAYLWPAAICCFLRPTAAVIWLPLSLYHLRRSRQNVLELILKRFVLIGLLVAGLGIA 189
           G +  +   A       P AA+I   + L  L R     L   L   ++     A + +A
Sbjct: 229 GAALCFSVLA--VVTGWPFAALISALVGLDLLLRFPVRTLACTLGSLLVA---CAAVFVA 283

Query: 190 IDTYWHGQLIVTPYEFLKYNIFNNIGS---FYGSHPWHWYFSVGLPTV 234
            D  ++ +  ++ +  + YN F   G     +G  P  +++   +   
Sbjct: 284 -DVRYYCRWTLSSWNVVMYNGFGGSGRGPELFGVEPIFFFWKNLMLNF 330
>ref|NP_069450.1| (NC_000917) conserved hypothetical protein [Archaeoglobus fulgidus]
 pir||H69326 conserved hypothetical protein AF0616 - Archaeoglobus fulgidus
 gb|AAB90624.1| (AE001062) conserved hypothetical protein [Archaeoglobus fulgidus]
          Length = 533

 Score = 45.0 bits (106), Expect = 0.003
 Identities = 24/106 (22%), Positives = 46/106 (42%), Gaps = 2/106 (1%)

Query: 223 WHWYFSVGLPTVLGINTLPFIFGVMETVKKSEKYPVSKQLLITIFLTLVVLSAVEHKEFR 282
           W +Y +  L  V  +  + F   +    K      +   LL  I L  ++L+ + +K+ R
Sbjct: 292 WIYYANSILDAVGAVFLILFAVSIYYLYKN--NRYLFLGLLTPIALIYIILTLLSNKDPR 349

Query: 283 FVSPLLPLCLYVITDALSRWSIRASSTMLWTTALVILVGNVMPAWY 328
           ++ P+LP     I   +S  + R  ST+L    L+  + N+    +
Sbjct: 350 YIMPVLPFVAISIGVFVSSLANRKYSTILTFIILLFGLLNISALTF 395
CPU time:   168.61 user secs.	    2.84 sys. secs	  171.45 total secs.

  Database: nr
    Posted date:  Apr 21, 2002  2:19 PM
  Number of letters in database: 277,845,442
  Number of sequences in database:  887,402
  
Lambda     K      H
   0.317    0.179    0.513 

Gapped
Lambda     K      H
   0.270   0.0629    0.230 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 387421791
Number of Sequences: 887402
Number of extensions: 22350998
Number of successful extensions: 96475
Number of sequences better than 10.0: 770
Number of HSP's better than 10.0 without gapping: 59
Number of HSP's successfully gapped in prelim test: 725
Number of HSP's that attempted gapping in prelim test: 95209
Number of HSP's gapped (non-prelim): 1420
length of query: 512
length of database: 277,845,442
effective HSP length: 51
effective length of query: 461
effective length of database: 232,587,940
effective search space: 107223040340
effective search space used: 107223040340
T: 11
A: 40
X1: 15 ( 6.9 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 40 (20.8 bits)
S2: 76 (33.6 bits)