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GPI Anchor Biosynthesis Report: YA93_SCHPO (GPI7 family, Schizosaccharomyces pombe)




BLASTP 2.1.1 [Aug-8-2000]





BLASTP 2.1.1 [Aug-8-2000]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= 
         (758 letters)

Database: nr
           887,402 sequences; 277,845,442 total letters

Searching..................................................

Converged !!!


Results of PSI-Blast iteration 6

Distribution of 57 Blast Hits on the Query Sequence


Sequences with E-value BETTER than threshold (0.002)
Sequences producing significant alignments: (bits) Value
sp|Q09782|YA93_SCHPO HYPOTHETICAL 85.7 KD PROTEIN C13G6.03 IN CH... 905 0.0
ref|NP_495820.1| (NM_063419) Yeast YJ10 like [Caenorhabditis ele... 707 0.0
ref|NP_012473.1| (NC_001142) Local Anesthetics Sensitive: involv... 704 0.0
gb|AAK52677.1|AF321466_1 (AF321466) putative protein Gpi7p [Yarr... 536 e-151
dbj|BAA82620.1| (AB030280) phosphatidylinositolglycan class N sh... 426 e-118
dbj|BAA82663.1| (AB030316) phosphatidylinositolglycan class N [M... 424 e-117
gb|AAH21148.1|AAH21148 (BC021148) Similar to phosphatidylinosito... 422 e-116
pir||T02245 hypothetical protein P1.11659_3 - human >gi|2984587|... 418 e-115
ref|NP_186787.1| (NM_111004) putative phosphatidylinositolglycan... 363 8e-99
ref|NP_013069.1| (NC_001144) Glycosylphosphatidylinositol (GPI) ... 360 6e-98
ref|NP_179839.1| (NM_127819) unknown protein [Arabidopsis thalia... 355 2e-96
ref|NP_491097.1| (NM_058696) Y54E10BR.1.p [Caenorhabditis elegans] 343 9e-93
gb|AAF57689.1| (AE003799) CG12263 gene product [Drosophila melan... 339 1e-91
dbj|BAB29186.1| (AK014165) data source:MGD, source key:MGI:13516... 336 6e-91
pir||T40715 hypothetical protein SPBC839.08c - fission yeast (S... 332 2e-89
gb|AAF59557.2| (AC024812) Hypothetical protein Y54E10BR.1 [Caeno... 327 4e-88
pir||T40030 hypothetical protein SPBC27B12.06 - fission yeast (... 323 4e-87
gb|AAF58853.1| (AE003831) CG2292 gene product [Drosophila melano... 299 9e-80
ref|NP_491750.1| (NM_059349) C27A12.9.p [Caenorhabditis elegans]... 296 8e-79
dbj|BAB55130.1| (AK027465) unnamed protein product [Homo sapiens] 266 8e-70
ref|NP_060203.1| (NM_017733) hypothetical protein FLJ20265 [Homo... 266 8e-70
ref|NP_194699.1| (NM_119115) nucleotide pyrophosphatase -like pr... 266 1e-69
gb|AAK25979.1|AF360269_1 (AF360269) putative nucleotide pyrophos... 264 3e-69
ref|NP_005012.1| (NM_005021) ectonucleotide pyrophosphatase/phos... 262 1e-68
ref|NP_194698.1| (NM_119114) nucleotide pyrophosphatase - like p... 260 9e-68
dbj|BAA02053.1| (D12485) The first in-frame ATG codon is located... 258 2e-67
pir||A39216 plasma cell membrane glycoprotein PC-1 - human >gi|7... 258 3e-67
ref|NP_006199.1| (NM_006208) ectonucleotide pyrophosphatase/phos... 256 1e-66
emb|CAB99365.1| (AL117378) dJ131F15.2 (phosphodiesterase I/nucle... 254 3e-66
gb|AAB61536.1| (U78788) alkaline phosphodiesterase [Rattus norve... 253 1e-65
dbj|BAA06333.1| (D30649) phosphodiesterase I [Rattus norvegicus] 252 1e-65
ref|NP_445987.1| (NM_053535) ectonucleotide pyrophosphatase/phos... 252 2e-65
ref|NP_062243.1| (NM_019370) alkaline phosphodiesterase [Rattus ... 252 2e-65
gb|AAL26912.1| (AF320054) ecto-nucleotide pyrophosphatase [Rattu... 252 2e-65
gb|AAK69653.1|AF340185_1 (AF340185) ecto-nucleotide pyrophosphat... 252 2e-65
pir||A57080 cell surface antigen RB13-6 - rat >gi|806379|emb|CAA... 249 2e-64
pir||T33724 hypothetical protein - Zymomonas mobilis >gi|3089614... 248 2e-64
ref|NP_032839.2| (NM_008813) phosphodiesterase I/nucleotide pyro... 248 2e-64
gb|AAK84174.1|AF339910_1 (AF339910) ectonucleotide pyrophosphata... 248 2e-64
pir||A27410 plasma cell membrane glycoprotein PC-1 - mouse 248 2e-64
sp|P06802|PC1_MOUSE Ectonucleotide pyrophosphatase/phosphodieste... 247 6e-64
ref|XP_056208.1| (XM_056208) hypothetical protein MGC3079 [Homo ... 232 2e-59
pir||T03293 nucleotide pyrophosphatase homolog - rice >gi|818849... 230 5e-59
ref|NP_194697.1| (NM_119113) nucleotide pyrophosphatase - like p... 212 2e-53
Alignments
>sp|Q09782|YA93_SCHPO HYPOTHETICAL 85.7 KD PROTEIN C13G6.03 IN CHROMOSOME I
 pir||S62432 major facilitator protein homolog - fission yeast
           (Schizosaccharomyces pombe)
 pir||T37638 major facilitator protein homolog - fission yeast
           (Schizosaccharomyces pombe)
 emb|CAA91096.1| (Z54308) putative major facilitator superfamily protein
           [Schizosaccharomyces pombe]
          Length = 758

 Score =  905 bits (2315), Expect = 0.0
 Identities = 758/758 (100%), Positives = 758/758 (100%)

Query: 1   MRFAFFGIFWLQIFGSILFLLGFFPHKNDSTGKAMSNQFSPPAVIDQVVFVMVDALRADF 60
           MRFAFFGIFWLQIFGSILFLLGFFPHKNDSTGKAMSNQFSPPAVIDQVVFVMVDALRADF
Sbjct: 1   MRFAFFGIFWLQIFGSILFLLGFFPHKNDSTGKAMSNQFSPPAVIDQVVFVMVDALRADF 60

Query: 61  VFSKSHNMPFTQSLLYNSTHGIGFSAFARSPTVTMPRLKALTTGTIPGFLDVLLNIAESD 120
           VFSKSHNMPFTQSLLYNSTHGIGFSAFARSPTVTMPRLKALTTGTIPGFLDVLLNIAESD
Sbjct: 61  VFSKSHNMPFTQSLLYNSTHGIGFSAFARSPTVTMPRLKALTTGTIPGFLDVLLNIAESD 120

Query: 121 TGSSIEAQDSWVYQLNSFNKKIEFYGDDTWLKLFPSAFSKFEGTTSFFVSDYTEVDNNVT 180
           TGSSIEAQDSWVYQLNSFNKKIEFYGDDTWLKLFPSAFSKFEGTTSFFVSDYTEVDNNVT
Sbjct: 121 TGSSIEAQDSWVYQLNSFNKKIEFYGDDTWLKLFPSAFSKFEGTTSFFVSDYTEVDNNVT 180

Query: 181 RNFDHALPSSLSHSWDALILHYLGVDHIGHLYGPSSPLLNIKLLEIDTIISRIYKYLQEY 240
           RNFDHALPSSLSHSWDALILHYLGVDHIGHLYGPSSPLLNIKLLEIDTIISRIYKYLQEY
Sbjct: 181 RNFDHALPSSLSHSWDALILHYLGVDHIGHLYGPSSPLLNIKLLEIDTIISRIYKYLQEY 240

Query: 241 DEKTNTHSLIVLCGDHGMNEVGNHGGSSSGETTAALSLLFPSNELSHINKPILNMDDNPY 300
           DEKTNTHSLIVLCGDHGMNEVGNHGGSSSGETTAALSLLFPSNELSHINKPILNMDDNPY
Sbjct: 241 DEKTNTHSLIVLCGDHGMNEVGNHGGSSSGETTAALSLLFPSNELSHINKPILNMDDNPY 300

Query: 301 SILERVEQVDVVPTICLLLGIPIPKGNMGKVLSPVTELWKDTKTAKMAALSNLFQLSLLK 360
           SILERVEQVDVVPTICLLLGIPIPKGNMGKVLSPVTELWKDTKTAKMAALSNLFQLSLLK
Sbjct: 301 SILERVEQVDVVPTICLLLGIPIPKGNMGKVLSPVTELWKDTKTAKMAALSNLFQLSLLK 360

Query: 361 NPSLTTSELSTQFQDSDLNDIRLALENLQSQMVAQSSSYSLDRMLVAISILGACSILSLI 420
           NPSLTTSELSTQFQDSDLNDIRLALENLQSQMVAQSSSYSLDRMLVAISILGACSILSLI
Sbjct: 361 NPSLTTSELSTQFQDSDLNDIRLALENLQSQMVAQSSSYSLDRMLVAISILGACSILSLI 420

Query: 421 LFRNLYNYKELLAFAPFVVQNIIIVFSSSFIEEEHVIWYFAAVSLSLLQLLNPKTRLAGS 480
           LFRNLYNYKELLAFAPFVVQNIIIVFSSSFIEEEHVIWYFAAVSLSLLQLLNPKTRLAGS
Sbjct: 421 LFRNLYNYKELLAFAPFVVQNIIIVFSSSFIEEEHVIWYFAAVSLSLLQLLNPKTRLAGS 480

Query: 481 LQLFCLSIIKRWNQTGQKYSDLRDIVDDFIAPSTFMKTILCVTSAFMPAIRSPSPINFLS 540
           LQLFCLSIIKRWNQTGQKYSDLRDIVDDFIAPSTFMKTILCVTSAFMPAIRSPSPINFLS
Sbjct: 481 LQLFCLSIIKRWNQTGQKYSDLRDIVDDFIAPSTFMKTILCVTSAFMPAIRSPSPINFLS 540

Query: 541 SMFIAFYKLMPIISKHLNELPIIASFDYTFFVRIIWSLLLISFLSKPTFKQLRCQLSLFI 600
           SMFIAFYKLMPIISKHLNELPIIASFDYTFFVRIIWSLLLISFLSKPTFKQLRCQLSLFI
Sbjct: 541 SMFIAFYKLMPIISKHLNELPIIASFDYTFFVRIIWSLLLISFLSKPTFKQLRCQLSLFI 600

Query: 601 LLLTRLENMGLYLLYDIWQRTMPEEGTLASVMYYVAEQVAFFSLGNSNSLATVDLSQAYT 660
           LLLTRLENMGLYLLYDIWQRTMPEEGTLASVMYYVAEQVAFFSLGNSNSLATVDLSQAYT
Sbjct: 601 LLLTRLENMGLYLLYDIWQRTMPEEGTLASVMYYVAEQVAFFSLGNSNSLATVDLSQAYT 660

Query: 661 GLDSYNIFAVGILLFTSVFAGALWWCLHQPKRMMDRSVKTFWIMSSISLTFLCISCFIMR 720
           GLDSYNIFAVGILLFTSVFAGALWWCLHQPKRMMDRSVKTFWIMSSISLTFLCISCFIMR
Sbjct: 661 GLDSYNIFAVGILLFTSVFAGALWWCLHQPKRMMDRSVKTFWIMSSISLTFLCISCFIMR 720

Query: 721 HHLFVWSVFSPKLLYNASWASMYFLAKCLISTIMVRLR 758
           HHLFVWSVFSPKLLYNASWASMYFLAKCLISTIMVRLR
Sbjct: 721 HHLFVWSVFSPKLLYNASWASMYFLAKCLISTIMVRLR 758
>ref|NP_495820.1| (NM_063419) Yeast YJ10 like [Caenorhabditis elegans]
 pir||T21487 hypothetical protein F28C6.4 - Caenorhabditis elegans
 emb|CAA92675.1| (Z68315) Similarity to Yeast hypothetical protein YJ10
           (SW:YJ10_YEAST)~cDNA EST yk160e12.5 comes from this
           gene~cDNA EST yk160e12.3 comes from this gene~cDNA EST
           yk317h4.3 comes from this gene~cDNA EST yk317h4.5 comes
           from this gene [Caenorhabditis ele>
          Length = 795

 Score =  707 bits (1807), Expect = 0.0
 Identities = 244/766 (31%), Positives = 388/766 (49%), Gaps = 59/766 (7%)

Query: 10  WLQIFGSILFLLGFFPHKNDST------GKAMSNQFSPPAVIDQVVFVMVDALRADFVFS 63
            L +    L +  F       T      G    NQ S  +   ++VF+++DA R  F+ S
Sbjct: 63  VLVVCACALLVYSFVALDITPTPPTEEFGFKDGNQESSSSP--RLVFMVIDAFRLSFLTS 120

Query: 64  KSHNMPFTQSLLYNSTHGIGFSAFARSPTVTMPRLKALTTGTIPGFLDVLLNIAESDTGS 123
               M FT+S +   +    F A+AR PTVT+PR+ A  TGT+P F  VL N+A ++  +
Sbjct: 121 SKSPMSFTKSEITKKS-AKLFDAYARMPTVTLPRITAYLTGTLPSFGTVLTNLATAEMKT 179

Query: 124 SIEAQDSWVYQLNSFNKKIEFYGDDTWLKLFPSAFSKFEGTTSFFVSDYTEVDNNVTRNF 183
           +     +W+ ++    KK+ F+GDDTW++L P +F KFEG TSFFVSDYT+VDNNVTR+ 
Sbjct: 180 A-----NWISRIQKIGKKVHFFGDDTWIRLLPRSFEKFEGVTSFFVSDYTDVDNNVTRHL 234

Query: 184 DHALPSSLSHSWDALILHYLGVDHIGHLYGPSSPLLNIKLLEIDTIISRIYKYLQEYDEK 243
           D  L S+ +HSWDALILHYLG+DHIGH  G SS  +  KL E+D +I RI+KYL+     
Sbjct: 235 DTEL-SNTNHSWDALILHYLGLDHIGHSLGGSSSKIPEKLKEMDDVIGRIHKYLKS-STS 292

Query: 244 TNTHSLIVLCGDHGMNEVGNHGGSSSGETTAALSLLFPSNELSHINKPILNMDDNPYSIL 303
            +  S +++CGDHGM   G+HGG+S  ET   + +     E    NK   N DD      
Sbjct: 293 VDQESYLIVCGDHGMTAAGSHGGASPDETRVPVVIWKFGREEG--NKNYGNQDD-SLKQP 349

Query: 304 ERVEQVDVVPTICLLLGIPIPKGNMGKVLSPVTELWKDTKTAKMAALSNLFQLSLLKNPS 363
            R+EQ+DV  TI  +  +PIP  + G     +   + D +        N F+  +++   
Sbjct: 350 PRIEQIDVSSTIFDVFNMPIPIESYGIS---LINYFSDDEEEYFEKQHNQFR-RIVQAKH 405

Query: 364 LTTSELSTQFQDSDLNDIRLALE----NLQSQMVAQSSSYSLDRMLVAISILGACSILSL 419
           L  S++  +  D     I+ AL+     +QS+++  +S      + V + +L     LS+
Sbjct: 406 LAISDICDENCDYSDKFIKSALKKWFLTVQSELIGSASEVPNKSLGVCVFLLLVALTLSM 465

Query: 420 ILFRNLYNYKELLAFAPFVVQNIIIVFSSSFIEEEHVIWYFAAVSLSLLQLLN-----PK 474
            L+ NL+  K    F  F++   I  F+SS IEEEH IWY+   ++  ++ L       K
Sbjct: 466 GLW-NLHLSK--SDFFIFLIN--ITYFASSLIEEEHEIWYYLGSTVVAIRALRNFKIWNK 520

Query: 475 TRLAGSLQLFCLSIIKRWNQTGQKYSDLRDIVDDFIAPSTFMKTILCVTSAFMPAIRSPS 534
           T +     +F L+ + R   +  + +  R I+D  + P +     L      +  I +  
Sbjct: 521 TEVK---SIFFLAFLHRIACSYTQSTRRRWIMDSSLLPPSIFSDTLDFQPNNLNTILNEY 577

Query: 535 PINFL--SSMFI-------AFYKLMPIISKHLNELPIIASFDYTFFVRIIWSLLLISFLS 585
           PI  +   S+F         F+ ++P++S H   L  +  F+      I  S+L IS+  
Sbjct: 578 PIIVILTCSLFWMYGYKQSKFHIILPMVS-HFLRLFELTQFNEVLMHFIRLSILPISY-- 634

Query: 586 KPTFKQLRCQLSLFILLLTRLENMGLYLLYDIWQRTMPEEGTLASVMYYVAEQVAFFSLG 645
             T   L   L L + ++   + + L ++Y++ +  +  +  L SV +      +FF  G
Sbjct: 635 -STGSVLAGCLPLLLAIVPVSQILLLLVIYNMGK--LFSKLNLGSVEFVTLCMSSFFYTG 691

Query: 646 NSNSLATVDLSQAYTGLDSYNIFAVGILLFTSVFAGALWW-CLHQPKRMMDRSVKTF-WI 703
           NSNSL+T+ L+ AY GL SY    VG+ L    F+G + + C              F + 
Sbjct: 692 NSNSLSTLSLTSAYVGLSSYQPILVGLQLMLYTFSGPILFLCGCNASSCTSLLNHLFSYR 751

Query: 704 MSSISLTFLCISCFIMRHHLFVWSVFSPKLLYNASWASMYFLAKCL 749
           +SS+  + +C+  +I ++HLF+WSV+SPK++Y+ +    + L   L
Sbjct: 752 ISSMCTSLICL--YIFQNHLFIWSVYSPKVVYDMAHVIFFGLIGLL 795
>ref|NP_012473.1| (NC_001142) Local Anesthetics Sensitive: involved in the attachment
           of glycosylphosphatidylinositol (GPI) anchors to
           proteins.; Las21p [Saccharomyces cerevisiae]
 sp|P40367|YJG2_YEAST HYPOTHETICAL 94.9 KD PROTEIN IN MRPL8-NUP82 INTERGENIC REGION
 pir||S50810 probable membrane protein YJL062w - yeast (Saccharomyces
           cerevisiae)
 emb|CAA84061.1| (Z34288) HRC830 [Saccharomyces cerevisiae]
 emb|CAA89353.1| (Z49337) ORF YJL062w [Saccharomyces cerevisiae]
          Length = 830

 Score =  704 bits (1799), Expect = 0.0
 Identities = 252/830 (30%), Positives = 409/830 (48%), Gaps = 100/830 (12%)

Query: 1   MRFAFFGIF-WLQIFGSILFLLGFFPHKNDSTGKAMSN-----QFSPPAVIDQVVFVMVD 54
           M    F      Q+   +LF+  FFP K   TG +  +              ++VFV++D
Sbjct: 1   MNLKQFTCLSCAQLLAILLFIFAFFPRKIVLTGISKQDPDQDRDLQRDRPFQKLVFVIID 60

Query: 55  ALRADFVFSK--SHNMPFTQSLLYNSTHGIGFSAFARSPTVTMPRLKALTTGTIPGFLDV 112
           ALR+DF+F    SH     Q L  N+    G+++FA  PTVT+PRLK++TTG+ P F+D+
Sbjct: 61  ALRSDFLFDSQISHFNNVHQWL--NTGEAWGYTSFANPPTVTLPRLKSITTGSTPSFIDL 118

Query: 113 LLNIAESDTGSSIEAQDSWVYQLNSFNKKIEFYGDDTWLKLFPSAFSKF-EGTTSFFVSD 171
           LLN+A+    + +   DSW+ Q    N  I F GDDTWLKLFP  +  F + T SFFVSD
Sbjct: 119 LLNVAQDIDSNDLSEHDSWLQQFIQHNNTIRFMGDDTWLKLFPQQWFDFADPTHSFFVSD 178

Query: 172 YTEVDNNVTRNFDHALPSSLSHSWDALILHYLGVDHIGHLYGPSSPLLNIKLLEIDTIIS 231
           +T+VDNNVTRN    L       WD  ILHYLG+DHIGH  GP S  +  K  E+D+I+ 
Sbjct: 179 FTQVDNNVTRNLPGKLFQEW-AQWDVAILHYLGLDHIGHKDGPHSKFMAAKHQEMDSILK 237

Query: 232 RIYKYLQEYDEKTNTHSLIVLCGDHGMNEVGNHGGSSSGETTAALSLLFPSN-------E 284
            IY  +   + + +  +LI + GDHGMNE+GNHGGSS+GET+A L  L P          
Sbjct: 238 SIYDEV--LEHEDDDDTLICVLGDHGMNELGNHGGSSAGETSAGLLFLSPKLAQFARPES 295

Query: 285 LSHINKPILNMDDNPYSILERVEQVDVVPTICLLLGIPIPKGNMGKVLSPVTELWKDTKT 344
             +   PI    D  +  LE V+Q+D+VPTI  L G+PIP  ++G ++    +L  +   
Sbjct: 296 QVNYTLPINASPDWNFQYLETVQQIDIVPTIAALFGMPIPMNSVGIIIPDFLQLLPN--- 352

Query: 345 AKMAALSNLFQLSLLKNPSLTTSELSTQFQDSDLNDIRLALENLQSQMVAQSSSYSLDRM 404
            K+A++   F + L K   L+         D    DI   +  +Q  +   +++Y+   +
Sbjct: 353 -KLASMKENF-MHLWK---LSDHHGEVALDDFTAEDIYTKMYTIQETLTKSATNYNYPLL 407

Query: 405 LVAISILGACSILSLILF-----RNLYNYKELLAFAPFVVQNI-IIVFSSSFIEEEHVIW 458
            +A       +I+++ +       + +  +        V   + +  F+SSFIEEEH +W
Sbjct: 408 TLAFVGFLIITIIAIYVLLRYSGPDFWQLRVSSLSVLLVSIILGVSTFASSFIEEEHQLW 467

Query: 459 YFAAVSLSLLQL----LNPKTRLAGSLQLFCLSIIKRWNQTGQKYSDLRDIVDDFIAPST 514
           ++   + S + L    LN    +   + + C+  IK WN +GQK+    +++ + +  + 
Sbjct: 468 WWIVTAFSAVPLFVYRLNVLIIVRWFIMMACVRSIKFWNNSGQKFIY-SNVMSNLLNQNP 526

Query: 515 FMKTILCVTSAFMPAIRSPSPINFL----SSMFIAF---YKL-MPIISKHLNELP----- 561
             K  L + +  +  I + +    L    +++ +     YK+   I++ +  E+P     
Sbjct: 527 SWKWCLNMLTF-LVLIMASAGFQVLHFIVTTILVGLCFTYKISWEIVNGNQAEIPLFMHD 585

Query: 562 IIASFDYT-------FFVRII---WSLLLISFL---------SKPTFKQLRCQLSLFILL 602
           ++A  D+           R+    W++++IS L              K ++  +++ ++ 
Sbjct: 586 LLAKIDFAPTESNLIVLARVFFQAWAIVVISRLVLTKLKVLNKNYLIKDMKVYITILLMF 645

Query: 603 LTRLENMGLYLLYDI--------WQRTMPEEGTLASVMYY------VAEQVAFFSLGNSN 648
            T  +N+G +L++ I        +Q       T  S +Y+      + +   FF  G +N
Sbjct: 646 QTSSQNIGQFLVFQILESQIFYFFQNIPTASLTSTSKIYFSNLVSLILQNFTFFQFGGTN 705

Query: 649 SLATVDLSQAYTGLDS-YNIFAVGILLFTSVFAGALWWCL-----HQPKRMMDRSVKTFW 702
           S++T+DL  AY G+ S YNI+ VGIL+  + FA A++W +     +         ++TF 
Sbjct: 706 SISTIDLGNAYHGVSSDYNIYVVGILMSVANFAPAIYWSMLPWSINYASIPAQVKLQTFI 765

Query: 703 IMSSISLTFLCIS-------CFIMRHHLFVWSVFSPKLLYNASWASMYFL 745
                + T+ CI        C ++R HLF+WSVFSPKL Y   W  +  L
Sbjct: 766 RSKLPAFTYHCIFGTCLMTACVVLRFHLFIWSVFSPKLCYFLGWNFVMGL 815
>gb|AAK52677.1|AF321466_1 (AF321466) putative protein Gpi7p [Yarrowia lipolytica]
          Length = 860

 Score =  536 bits (1367), Expect = e-151
 Identities = 198/539 (36%), Positives = 282/539 (51%), Gaps = 35/539 (6%)

Query: 4   AFFGIFWLQIFGSILFLLGFFPHKNDSTGKAMSNQFSPPAVIDQVVFVMVDALRADFVFS 63
               I  LQ+   +LF  GF P +    G   S + S  A   + + ++VDA R+DF FS
Sbjct: 8   LAVTIVVLQLAAVLLFARGFLPSRVLLPGYTES-RVSTEAPFQKAIIMVVDAFRSDFAFS 66

Query: 64  KSHNMPFTQSLLYNSTHGIGFSAFARSPTVTMPRLKALTTGTIPGFLDVLLNIAESDTGS 123
              N P     + NS   I F+A +  PTVT+PR+K LTTG+ P FLD +LNIAESD  S
Sbjct: 67  DQSNCPQLHKRI-NSGGAIPFTAHSTPPTVTLPRIKGLTTGSTPNFLDAVLNIAESDNSS 125

Query: 124 SIEAQDSWVYQLNSFNKKIEFYGDDTWLKLFPSAFSKFEGTTSFFVSDYTEVDNNVTRNF 183
           ++  QDSW+ Q +   +KI  +GDDTW+KLFP  F   EGT SFFVSDYTEVDNNVTR+ 
Sbjct: 126 TLANQDSWLAQASRDGRKIHMFGDDTWIKLFPGMFDDCEGTASFFVSDYTEVDNNVTRHI 185

Query: 184 DHALPSSLSHSWDALILHYLGVDHIGHLYGPSSPLLNIKLLEIDTIISRIYKYLQEYDEK 243
           D  L       WD LILHYLG+DHIGH  GP SP +  K  E+D I  ++Y         
Sbjct: 186 DTQLDQKT--EWDVLILHYLGLDHIGHKTGPESPFMPAKQKEMDDIFDKLYNS------- 236

Query: 244 TNTHSLIVLCGDHGMNEVGNHGGSSSGETTAALSLLFPSNELSHINK-----PILNMDDN 298
            +  ++++L GDHGMNEVGNHGGSS+GET+AA+    P  E + + +     P+   D  
Sbjct: 237 CDDDTVLILLGDHGMNEVGNHGGSSAGETSAAMVFASPKFETAQLTETAETSPLPWTDTY 296

Query: 299 PYSILERVEQVDVVPTICLLLGIPIPKGNMGKVLSPVTELWKDTKTAKMAALSNLFQLSL 358
            Y    R++Q D+VPT+  LLG+  PK N+G ++S +  LW       +   +    + +
Sbjct: 297 KYHS--RMDQTDLVPTLTALLGLNTPKNNLGVLVSQMLGLWSPEDQLNVLKNNADQMVQI 354

Query: 359 LKNPSLTTSELSTQFQDSD-------LNDIRLALENLQSQMVAQSSSYSLDRMLVAISIL 411
           L+  +   S+    ++  D       + D    L   QS +   SS+Y+ + ML  I + 
Sbjct: 355 LQGQASRESDAKEVYELYDTLNSNPSVKDYYNFLYEAQSYLTHASSNYNTNDMLGGIGLG 414

Query: 412 GACSILSLILFRNLYNYKELLA--FAPFVVQNIIIVFSSSFIEEEHVIWYFAAVS-LSLL 468
              +IL+L +F  L    + L   +   ++   I VF SS +EEEH IWY+     ++ L
Sbjct: 415 LLSTILALTVFSALTLAVQGLKRLYLIILLVYFISVFGSSTVEEEHQIWYWITSGWMAFL 474

Query: 469 QLLNPKTRLAGSLQLFCLSIIKR----WNQTGQKYSDLRDIVDDF---IAPSTFMKTIL 520
            +   + +         + +  R    WNQTGQK++   DIV          +    IL
Sbjct: 475 YISGSRNKFGDGFNWMFVQVFVRMMISWNQTGQKFTKKDDIVTWLSKDGNQPSLWILIL 533
 Score =  192 bits (484), Expect = 2e-47
 Identities = 71/255 (27%), Positives = 119/255 (45%), Gaps = 55/255 (21%)

Query: 558 NELPIIASFDY-TFFVRIIWSLLLISFL-SKPTFKQLRCQLSLFILLLTRLENMGLYLLY 615
             +  +A F + T     ++ +L ++        + L   L+LF++  +R++N+ L+++Y
Sbjct: 601 ARMAGLARFAFSTIAAGSLYRVLSLAGTDKVNLIRDLHAFLTLFLITQSRIQNIPLFMVY 660

Query: 616 --------------------DIWQR--TMPEEGTLASVMYYVAEQVAFFSLGNSNSLATV 653
                               DI+Q      +   + SV   + EQV+FFS+GNSNS+A++
Sbjct: 661 YFLEIFLRKATNRSFIFSSRDIYQTEALFQKLVLVLSVSTLLLEQVSFFSMGNSNSMASI 720

Query: 654 DLSQAYTGLDSYNIFAVGILLFTSVFAGALWWC--------------------------- 686
           DLS AY G+  Y I  VG+L F S + G L+W                            
Sbjct: 721 DLSNAYNGVTLYQIEFVGVLTFVSNWIGPLYWSTAGLSFLLEDHVRNAIFAKIAEKNNDV 780

Query: 687 ---LHQPKRMMDRSVKTFWIMSSISLTFLCISCFIMRHHLFVWSVFSPKLLYNASWASMY 743
                  ++ +   V      SS++++ + I+CF +R HLF+W+VFSPKLLY   W  + 
Sbjct: 781 KLTTKLVQQALTLRVYVVLAFSSVAISAVMITCFFLREHLFIWTVFSPKLLYQFVWTVLQ 840

Query: 744 F-LAKCLISTIMVRL 757
           F L   ++S+I V L
Sbjct: 841 FALVDVILSSIFVVL 855
>dbj|BAA82620.1| (AB030280) phosphatidylinositolglycan class N short form [Mus
           musculus]
          Length = 798

 Score =  426 bits (1085), Expect = e-118
 Identities = 82/425 (19%), Positives = 150/425 (35%), Gaps = 48/425 (11%)

Query: 3   FAFFGIFWLQIFGSILFLLGFFPHKNDSTGKAMSNQF-SPPAVIDQVVFVMVDALRADFV 61
           F   G+    +F   +F + F           M+ QF   P    ++V  + D LRAD +
Sbjct: 4   FFALGLLIHFVFFVSIFDIYF----TSPLVHGMTPQFTPLPPPAKRLVLFVADGLRADTL 59

Query: 62  FSKSH----NMPFTQSLLYNSTHGIGFSAFARSPTVTMPRLKALTTGTIPGFLDVLLNIA 117
           +          PF ++++     G    +  R PT + P   AL  G    F + +  +A
Sbjct: 60  YELDEDGNSRAPFIRNVIM--HEGSWGVSHTRVPTESRPGHVALIAG----FYEDVSAVA 113

Query: 118 ESDTGSSIEAQDSWVYQLNSFNKKIEFYGDDTWLKLFPSA--------FSKFEGTTSFFV 169
           +    + +E        L + +K    +G    L +F           +S       F  
Sbjct: 114 KGWKENPVEFD-----SLFNESKYTWSWGSPDILPMFAKGASGDHVYTYSYDAQREDFGA 168

Query: 170 SDYTEVDNNVTRNFDH---------ALPSSLSHSWDALILHYLGVDHIGHLYGPSSPLLN 220
            D T++D  V               +L + ++       LH LGVD  GH + PSS    
Sbjct: 169 HDATKLDTWVFDKVKDFFDAARNNQSLFTKVNEEKVVFFLHLLGVDTNGHAHRPSSREYK 228

Query: 221 IKLLEIDTIISRIYKYLQEYDEKTNTHSLIVLCGDHGMNEVGNHGGSSSGETTAALSLLF 280
             + ++D  +  I    + +    +  +  +   DHGM + G+HG     ET        
Sbjct: 229 DNIKKVDDGVKEIVSIFKHFYG-DDGKTAFIFTSDHGMTDWGSHGAGHPSETLTPFVTWG 287

Query: 281 PSNELS------HINKPILNMDDNPYSILERVEQVDVVPTICLLLGIPIPKGNMGKVLSP 334
              +          +   L            V Q D+ P +  L+G+P P  ++G +  P
Sbjct: 288 AGIKFPQNVSAQQYDDEFLKEWRLENWKRRDVNQADIAPLMASLIGVPFPLNSVGIL--P 345

Query: 335 VTELWKDTKTAKMAALSNLFQLSLLKNPSLTTSELSTQFQDSDLNDIRLALENLQSQMVA 394
           V  L         +  +N  Q  +L+   +  ++             +L  ++ Q  ++ 
Sbjct: 346 VGYLNNTGLFKAESMFTNAVQ--ILEQFKVKMTQKKEATLPFLFTPFKLLSDSQQLDILR 403

Query: 395 QSSSY 399
           ++ SY
Sbjct: 404 KARSY 408
>dbj|BAA82663.1| (AB030316) phosphatidylinositolglycan class N [Mus musculus]
          Length = 391

 Score =  424 bits (1079), Expect = e-117
 Identities = 77/408 (18%), Positives = 141/408 (33%), Gaps = 48/408 (11%)

Query: 3   FAFFGIFWLQIFGSILFLLGFFPHKNDSTGKAMSNQF-SPPAVIDQVVFVMVDALRADFV 61
           F   G+    +F + +F + F           M+ QF   P    ++V  + D LRAD +
Sbjct: 4   FFALGLLIHFVFFASIFDIYF----TSPLVHGMTPQFTPLPPPAKRLVLFVADGLRADTL 59

Query: 62  FSKSH----NMPFTQSLLYNSTHGIGFSAFARSPTVTMPRLKALTTGTIPGFLDVLLNIA 117
           +          PF ++++     G    +  R PT + P   AL  G    F + +  +A
Sbjct: 60  YELDEDGNSRAPFIRNVIM--HEGSWGVSHTRVPTESRPGHVALIAG----FYEDVSAVA 113

Query: 118 ESDTGSSIEAQDSWVYQLNSFNKKIEFYGDDTWLKLFPSA--------FSKFEGTTSFFV 169
           +    + +E        L + +K    +G    L +F           +S       F  
Sbjct: 114 KGWKENPVEFD-----SLFNESKYTWSWGSPDILPMFAKGASGDHVYTYSYDAQREDFGA 168

Query: 170 SDYTEVDNNVTRNFDH---------ALPSSLSHSWDALILHYLGVDHIGHLYGPSSPLLN 220
            D T++D  V               +L + ++       LH LG+D  GH + PSS    
Sbjct: 169 HDATKLDTWVFDKVKDFFDAARNNQSLFTKVNEEKVVFFLHLLGIDTNGHAHRPSSREYK 228

Query: 221 IKLLEIDTIISRIYKYLQEYDEKTNTHSLIVLCGDHGMNEVGNHGGSSSGETTAALSLLF 280
             + ++D  +  I    + +    +  +  +   DHGM + G+HG     ET        
Sbjct: 229 DNIKKVDDGVKEIVSIFKHFYG-DDGKTAFIFTSDHGMTDWGSHGAGHPSETLTPFVTWG 287

Query: 281 PSNELS------HINKPILNMDDNPYSILERVEQVDVVPTICLLLGIPIPKGNMGKVLSP 334
              +          +   L            V Q D+ P +  L+G+P P  ++G +  P
Sbjct: 288 AGIKFPQNVSAQQYDDEFLKEWRLENWKRRDVNQADIAPLMASLIGVPFPLNSVGIL--P 345

Query: 335 VTELWKDTKTAKMAALSNLFQLSLLKNPSLTTSELSTQFQDSDLNDIR 382
           V  L         +  +N  Q  +L+   +  ++             +
Sbjct: 346 VGYLNNTGLFKAESMFTNAVQ--ILEQFKVKMTQKKEATLPFLFTPFK 391
>gb|AAH21148.1|AAH21148 (BC021148) Similar to phosphatidylinositol glycan, class N [Mus
           musculus]
          Length = 826

 Score =  422 bits (1074), Expect = e-116
 Identities = 81/425 (19%), Positives = 151/425 (35%), Gaps = 48/425 (11%)

Query: 3   FAFFGIFWLQIFGSILFLLGFFPHKNDSTGKAMSNQF-SPPAVIDQVVFVMVDALRADFV 61
           F   G+    +F + +F + F           M+ QF   P    ++V  + D LRAD +
Sbjct: 4   FFALGLLIHFVFFASIFDIYF----TSPLVHGMTPQFTPLPPPAKRLVLFVADGLRADTL 59

Query: 62  FSKSH----NMPFTQSLLYNSTHGIGFSAFARSPTVTMPRLKALTTGTIPGFLDVLLNIA 117
           +          PF ++++     G    +  R PT + P   AL  G    F + +  +A
Sbjct: 60  YELDEDGNSRAPFIRNVII--HEGSWGVSHTRVPTESRPGHVALIAG----FYEDVSAVA 113

Query: 118 ESDTGSSIEAQDSWVYQLNSFNKKIEFYGDDTWLKLFPSA--------FSKFEGTTSFFV 169
           +    + +E        L + +K    +G    L +F           +S       F  
Sbjct: 114 KGWKENPVEFD-----SLFNESKYTWSWGSPDILPMFAKGASGDHVYTYSYDAQREDFGA 168

Query: 170 SDYTEVDNNVTRNFDH---------ALPSSLSHSWDALILHYLGVDHIGHLYGPSSPLLN 220
            D T++D  V               +L + ++       LH LG+D  GH + PSS    
Sbjct: 169 HDATKLDTWVFDKVKDFFDAARNNQSLFTKVNEEKVVFFLHLLGIDTNGHAHRPSSREYK 228

Query: 221 IKLLEIDTIISRIYKYLQEYDEKTNTHSLIVLCGDHGMNEVGNHGGSSSGETTAALSLLF 280
             + ++D  +  I    + +    +  +  +   DHGM + G+HG     ET        
Sbjct: 229 DNIKKVDDGVKEIVSIFKHFYG-DDGKTAFIFTSDHGMTDWGSHGAGHPSETLTPFVTWG 287

Query: 281 PSNELS------HINKPILNMDDNPYSILERVEQVDVVPTICLLLGIPIPKGNMGKVLSP 334
              +          +   L            V Q D+ P +  L+G+P P  ++G +  P
Sbjct: 288 AGIKFPQNVSAQQYDDEFLKEWRLENWKRRDVNQADIAPLMASLIGVPFPLNSVGIL--P 345

Query: 335 VTELWKDTKTAKMAALSNLFQLSLLKNPSLTTSELSTQFQDSDLNDIRLALENLQSQMVA 394
           V  L         +  +N  Q  +L+   +  ++             +L  ++ Q  ++ 
Sbjct: 346 VGYLNNTGLFKAESMFTNAVQ--ILEQFKVKMTQKKEATLPFLFTPFKLLSDSQQLDILR 403

Query: 395 QSSSY 399
           ++ SY
Sbjct: 404 KARSY 408
>pir||T02245 hypothetical protein P1.11659_3 - human
 gb|AAC07985.1| (AC004472) P1.11659_3 [Homo sapiens]
          Length = 880

 Score =  418 bits (1064), Expect = e-115
 Identities = 132/419 (31%), Positives = 189/419 (44%), Gaps = 52/419 (12%)

Query: 3   FAFFGIFWLQIFGSILFLLGFFPHKNDSTGKAMSNQFSPP-----------------AVI 45
                + +L   G  LF  GF   + + T  +   +   P                 +  
Sbjct: 8   LFLAWVCFLFYAGIALFTSGFLLTRLELTNHSSCQEPPGPGSLPWGSQGKPGACWMASRF 67

Query: 46  DQVVFVMVDALRADFVFSKSHNMPFTQSLLYNSTHGIGFSAFARSPTVTMPRLKALTTGT 105
            +VV V++DALR DF   +       + L     H   + +    PT TM RLKALTTG+
Sbjct: 68  SRVVLVLIDALRFDFAQPQHS----HRILEIQPHHARLYRSQVDPPTTTMQRLKALTTGS 123

Query: 106 IPGFLDVLLNIAESDTGSSIEAQDSWVYQLNSFNKKIEFYGDDTWLKLFPSAFSKFEGTT 165
           +P F+D   N A     S    +D+ + QL S  +++ F GDDTW  LFP AFSK     
Sbjct: 124 LPTFIDAGSNFA-----SHAIVEDNLIKQLTSAGRRVVFMGDDTWKDLFPGAFSKAFFFP 178

Query: 166 SFFVSDYTEVDNNVTRNFDHALPSSLSHSWDALILHYLGVDHIGHLYGPSSPLLNIKLLE 225
           SF V D   VDN +  +     P+  S  WD LI H+LGVDH GH +GP  P +  KL +
Sbjct: 179 SFNVRDLDTVDNGILEHL---YPTMDSGEWDVLIAHFLGVDHCGHKHGPHHPEMAKKLSQ 235

Query: 226 IDTIISRIYKYLQEYDEKTNTHSLIVLCGDHGMNEVGNHGGSSSGETTAALSLLFPSNEL 285
           +D +I  + + L+         +L+V+ GDHGM   G+HGG S  E +AAL L  P+   
Sbjct: 236 MDQVIQGLVERLE-------NDTLLVVAGDHGMTTNGDHGGDSELEVSAALFLYSPTAVF 288

Query: 286 SHINKPILNMDDNPYSILERVEQVDVVPTICLLLGIPIPKGNMGKVLSPVTELWKDTKTA 345
                        P    E + QV +VPT+ LLLG+PIP GN+G+V++ +    +D+   
Sbjct: 289 P----------STPPEEPEVIPQVSLVPTLALLLGLPIPFGNIGEVMAELFSGGEDS-QP 337

Query: 346 KMAALSNLFQLSLLKNPSLT-TSELSTQFQDSDLNDIRLALENLQSQMVAQSSSYSLDR 403
             +AL+    L L            S   QD    +    L  LQ+     S+ Y    
Sbjct: 338 HSSALAQASALHLNAQQVSRFLHTYSAATQDLQAKE----LHQLQNLFSKASADYQWLL 392
 Score = 38.4 bits (89), Expect = 0.42
 Identities = 9/55 (16%), Positives = 20/55 (36%), Gaps = 3/55 (5%)

Query: 635 VAEQVAFFSLGNSNSLATVDLSQAYTGLDSYN---IFAVGILLFTSVFAGALWWC 686
           +     F+S G+      +    A+ G    +    +   +L+  + FA  L + 
Sbjct: 747 LMATQTFYSTGHQPVFPAIHWHAAFVGFPEGHGSCTWLPALLVGANTFASHLLFA 801
>ref|NP_186787.1| (NM_111004) putative phosphatidylinositolglycan class N short form
           [Arabidopsis thaliana]
 gb|AAF24617.1|AC010870_10 (AC010870) putative phosphatidylinositolglycan class N short form
           [Arabidopsis thaliana]
          Length = 921

 Score =  363 bits (923), Expect = 8e-99
 Identities = 78/446 (17%), Positives = 148/446 (32%), Gaps = 68/446 (15%)

Query: 3   FAFFGIFWLQIFGSILFLLGFFPHKNDSTGKAMSNQFSP--PAVIDQVVFVMVDALRADF 60
               G+    ++   +F + F           M             ++V ++ D LRAD 
Sbjct: 46  LVVLGVALHAVYMLSIFDIYF----KTPIVHGMDPVPPRFSEPPAKRLVLLISDGLRADK 101

Query: 61  VFSKSH----NMPFTQSLLYNSTHGIGFSAFARSPTVTMPRLKALTTGTIPGFLDVLLNI 116
            F          PF ++++ N   G    + AR PT + P   A+  G    F +    +
Sbjct: 102 FFEPDEEGKYRAPFLRNIIKN--QGRWGVSHARPPTESRPGHVAIIAG----FYEDPSAV 155

Query: 117 AESDTGSSIEAQDSWVYQLNSFNKKIEFYGDDTWLKLF-----PSAFSKFEGTTSFFVSD 171
            +    + +E    +    +        +G    + +F      S ++ +      F +D
Sbjct: 156 TKGWKANPVEFDSVFNQSRH-----TFAFGSPDIIPIFCSALPHSTWNSYPHEYEDFATD 210

Query: 172 YTEVDNNVTRNFDHALPSS---------LSHSWDALILHYLGVDHIGHLYGPSSPLLNIK 222
            + +D      F+  L  S         L      + LH LG D  GH + P S +    
Sbjct: 211 ASFLDEWSFDQFEGLLNRSHADPKLKELLHQDKLVVFLHLLGCDSNGHAHRPYSSIYLNN 270

Query: 223 LLEIDTIISRIYKYLQEYDEKTNTHSLIVLCGDHGMNEVGNHGGSSSGETTAALSLLFPS 282
           +  +D I  R+Y  L++Y    +  +  +   DHGM++ G+HG      T   L      
Sbjct: 271 VKVVDKIAERVYHLLEDYYR--DNRTSYIFTADHGMSDKGSHGDGHPTNTDTPLVAWGAG 328

Query: 283 NELSH-------------------INKPILNMDDNPYSILERVEQVDVVPTICLLLGIPI 323
            +                       + P              V Q D+ P +  LLG+P 
Sbjct: 329 IQYPKPASGNSHSDSVTTFVDKHAHDMPTPYDWGLRRVERVDVNQADIAPLMSTLLGLPC 388

Query: 324 PKGNMGKVLSPVTELWKDTKTAKMAALSNLFQLSLLKNPSLTTSELSTQFQDSDLNDIRL 383
           P  ++G +  P+  +  +      A ++N  Q+    N  L  S + +          + 
Sbjct: 389 PVNSVGNL--PLGYMKLNEAEEVEAVVANTKQI---LNQLLRKSYIKSSNSLFF-KPFKP 442

Query: 384 ALE------NLQSQMVAQSSSYSLDR 403
            +        +   + A+S   ++  
Sbjct: 443 LVHHSFSLSQIDELISAKSYEAAMKL 468
 Score = 40.0 bits (93), Expect = 0.14
 Identities = 20/96 (20%), Positives = 35/96 (35%), Gaps = 5/96 (5%)

Query: 629 ASVMYYVAEQVAFFSLGNSNSLATVDLSQAYTGLDSYNIFAVGILLFTSVFAGALWWCLH 688
             +++ V   VAFF  GN  S+A+ ++S  Y  +  ++ F +  LL   +F   +     
Sbjct: 774 IPLVFMVLFNVAFFGTGNFASIASFEISSVYRFITIFSPFLMAALLIFKLFIPFMLVICA 833

Query: 689 QPKRMMDRSVKTFWIMSSISLTFLCISCFIMRHHLF 724
                    V             + +   IM  H F
Sbjct: 834 FSAITKLVRVP-----RLGCYFLVILFSDIMTIHFF 864
>ref|NP_013069.1| (NC_001144) Glycosylphosphatidylinositol (GPI) biosynthesis; Gpi13p
           [Saccharomyces cerevisiae]
 pir||S64782 probable membrane protein YLL031c - yeast (Saccharomyces
           cerevisiae)
 emb|CAA97480.1| (Z73136) ORF YLL031c [Saccharomyces cerevisiae]
          Length = 1017

 Score =  360 bits (915), Expect = 6e-98
 Identities = 112/395 (28%), Positives = 180/395 (45%), Gaps = 33/395 (8%)

Query: 4   AFFGIFWLQIFGSILFLLGFFPHKNDSTGKAMSNQFS-PPAVIDQVVFVMVDALRADFVF 62
               I  LQ      F  GF   ++     +  N+ S  P   ++ V +++DALR DF  
Sbjct: 38  LLVFIAILQFISIAFFTRGFLLSRHVLDNISSQNETSKLPPRFNKAVILVIDALRFDFAI 97

Query: 63  S-----KSHNMPFTQSLLY--------NSTHGIGFSAFARSPTVTMPRLKALTTGTIPGF 109
                  ++N+ +  ++L              +     A  PT T+ RLK LTTG++P F
Sbjct: 98  PVNESHSNYNLNYHNNILSLYDSFASDKDASSLLLKFIADPPTTTLQRLKGLTTGSLPTF 157

Query: 110 LDVLLNIAESDTGSSIEAQDSWVYQLNSFNKKIEFYGDDTWLKLF-PSAFSKFEGTTSFF 168
           +D   N        ++  +D+++ QL+  NK ++F GDDTW+ LF P   +      S  
Sbjct: 158 IDAGSNFDG-----TVIEEDNFLKQLHLANKTVKFAGDDTWMALFHPFLSNDSFPLESLN 212

Query: 169 VSDYTEVDNNVTRNFDHALPSSLSHSWDALILHYLGVDHIGHLYGPSSPLLNIKLLEIDT 228
           V D   VDN V   F   L       WD +I H LG+DH+GH YGP    +  K +++D 
Sbjct: 213 VWDLDTVDNGVMDYFHDHLQQD--KEWDVMIGHMLGIDHVGHKYGPDHFTMREKQIQVDQ 270

Query: 229 IISRIYKYLQEYDEKTNTHSLIVLCGDHGMNEVGNHGGSSSGETTAALSLLFPSNELSHI 288
            I  I K +       +  +L+V+ GDHGM+  GNHGG S  E  + L L     ++  +
Sbjct: 271 FIDWILKSI-------DDDTLLVILGDHGMDHTGNHGGDSIDELESTLFLYSKKPDMWRL 323

Query: 289 NKPILNMDDNPYSILERVEQVDVVPTICLLLGIPIPKGNMGKVLSPVTELWKDTKTAKMA 348
            +      DN       V Q+D+V ++ LL+G PIP  N+G    P+ E+ ++ +     
Sbjct: 324 KETSNYNIDNLGHDYRSVRQIDLVSSLALLMGQPIPFNNLG---WPIDEIARNDREWSQF 380

Query: 349 ALSNLFQLSLLKNPSLTTSELSTQFQDSDLNDIRL 383
             S + QL L K+ ++     + +  +    +I  
Sbjct: 381 VNSAISQLQLYKD-TMQIHHGNDEILEPLAKNISN 414
 Score =  298 bits (757), Expect = 2e-79
 Identities = 53/369 (14%), Positives = 111/369 (29%), Gaps = 55/369 (14%)

Query: 434  FAPFVVQNIIIVFSSSFIEEEHVI------------WYFAAVSLSLLQLL--------NP 473
             A  ++   +    +   EE+               W+   +   ++ +L        N 
Sbjct: 649  SAVLIIFTRLASMITICREEQGEYCIPTFNNQNNSSWWVLGLCFLMIFILPACITGYYNL 708

Query: 474  KTRLAGSLQLFCLSIIKRWNQTGQKYSDLRDIVDDFIAPSTFMKT--ILCVTSAFMPAIR 531
             +    +  ++    +K     G  +      +      S  +    +  VT       R
Sbjct: 709  TSSYQAAAPIWINVFLKGI--LGLNFVY--WSLTSLENNSAVIAIPFLRDVTIFKFTLAR 764

Query: 532  SPSPINFLSSM---FIAFYKLMPIISKHLNELPIIASFDYTFFVRIIWSLLLISFLSKP- 587
              +  + ++S     +    +   I     +        YT      + LL+I+ L    
Sbjct: 765  IIAGFSLIASNVGWLMGPLCIKLNIHNTDVKSHEATILGYTNIYGSEFFLLVINVLISIL 824

Query: 588  TFKQLRCQLSLFILLLTRLENMGLYLLYDIWQRTMPEEGTLASVMYYVAEQVAFFSLGNS 647
             F +   QLS F++         L  + +I      +E  +  +   +     FF+ G+ 
Sbjct: 825  LFNKPLAQLSYFLMCNQ------LLSILEIIDLLKLKENIIGPIALGLLSYQHFFTTGHQ 878

Query: 648  NSLATVDLSQAYTGLDSYNIFA-VGILLFTSVFAGALWWCLHQP-----KRMMDRSVKTF 701
             ++ +V     +  L     F    I +  + F   +   L         +  D      
Sbjct: 879  ATIPSVQWDIGFM-LSEKVTFPFTQIAIILNTFGPHILVSLSVALLTLWSQPPDVLKPQT 937

Query: 702  WI--------MSSISLTFLCISCFI----MRHHLFVWSVFSPKLLYNASWASMYFLAKCL 749
             +        +     T LC+S FI     R HL VW +F P+ ++ +    +  L    
Sbjct: 938  LLGRIVSNCGILLTYNTILCLSSFIWVTHFRRHLMVWKIFCPRFIFASLSLIVTQLVVTF 997

Query: 750  ISTIMVRLR 758
             +      R
Sbjct: 998  GTIAFASGR 1006
>ref|NP_179839.1| (NM_127819) unknown protein [Arabidopsis thaliana]
 gb|AAF18652.1| (AC006592) unknown protein [Arabidopsis thaliana]
          Length = 897

 Score =  355 bits (903), Expect = 2e-96
 Identities = 135/389 (34%), Positives = 196/389 (49%), Gaps = 44/389 (11%)

Query: 3   FAFFGIFWLQIFGSILFLLGFFPHKNDSTGKAMSNQFSPP---------------AVIDQ 47
           F   GI  LQI G  +F+ GFFP K   +G + S  +  P                   +
Sbjct: 14  FTVAGIL-LQIIGLSIFVFGFFPVKPTLSGVSGSESYRDPFCDSSLISNESELHHPEKLR 72

Query: 48  VVFVMVDALRADFVFSKS---------HNMPFTQSLLYNSTHGIGFSAFARSPTVTMPRL 98
           +++ ++D L A+FV  K           +MP+TQSLL N    IG+ A A  PTVTMPRL
Sbjct: 73  LLYQVIDGLPAEFVLGKDGKPPEKVLKESMPYTQSLLANGD-AIGYHAKAAPPTVTMPRL 131

Query: 99  KALTTGTIPGFLDVLLNIAESDTGSSIEAQDSWVYQLNSFNKKIEFYGDDTWLKLFPSAF 158
           KA+ +G I GFLDV  N       +     D+ + Q      K+   GD+TWLKLFP  F
Sbjct: 132 KAMVSGAIGGFLDVAFNF-----NTQALLDDNILGQFFRIGWKMVMLGDETWLKLFPGLF 186

Query: 159 SKFEGTTSFFVSDYTEVDNNVTRNFDHALPSSLSHSWDALILHYLGVDHIGHLYGPSSPL 218
            + +G +SFFV D  +VD NV+R+    L S     W+ LILHYLG+DH+GH  G +SPL
Sbjct: 187 MRHDGVSSFFVKDTVQVDRNVSRHLPDELNSD---DWNLLILHYLGLDHVGHTGGRNSPL 243

Query: 219 LNIKLLEIDTIISRIYKYLQEYDEKTNTHSLIVLCGDHGMNEVGNHGGSSSGETTAALSL 278
           +  KL E+D I+  ++             +L+++  DHGM E GNHGGSS  ET + +  
Sbjct: 244 MPAKLKEMDDIVRTMHLRAMMDRSHDQGQTLLIIVSDHGMTENGNHGGSSYEETDSLMLF 303

Query: 279 LFPSNELSHINKPILNMDDNPYSILERVEQVDVVPTICLLLGIPIPKGNMGKVLSPVTEL 338
           +  +           N+ D   +      QVD+ PT+ LL G+PIPK N+G ++      
Sbjct: 304 IGLN----------SNISDYASATNNVAFQVDLAPTLALLFGVPIPKNNVGVLVPGTLCS 353

Query: 339 WKDTKTAKMAALSNLFQLSLLKNPSLTTS 367
            +D +  +   L++   L L+     ++S
Sbjct: 354 LRDFEQLRALELNSWQLLRLMLAQIQSSS 382
 Score =  293 bits (745), Expect = 5e-78
 Identities = 78/419 (18%), Positives = 148/419 (34%), Gaps = 82/419 (19%)

Query: 350 LSNLFQLS-LLKNPSLTTSELSTQFQDSDLNDIRLALENLQSQMVAQSSSYSLDRMLVAI 408
             N   L  + K+   T S  + +     L+     L+     + ++++   +  + + +
Sbjct: 418 FRNAAALHGIWKSKKSTESSSTMEDFSRALDAYNTFLKTASEWLASKTTEKPVLLLGLGV 477

Query: 409 SILGACSILSLILF------------------RNLYNYKELLAFAPFVVQNIIIVFSSSF 450
           S +     +   +F                   NL N +E+  FA  ++  +I + SSS 
Sbjct: 478 SAMLLSCFICGTVFLSLFKEVYHEPKDRVCSLSNLLNLEEVFIFALLLI-LVISMGSSSM 536

Query: 451 IEEEHVIWYFAAVSLSLL---------QLLNPKTRLAGSL--QLFCL----SIIKRWNQT 495
           +EEEH IW+F   +  LL         ++      L       +F L     +++ W+Q 
Sbjct: 537 VEEEHYIWHFMVSTFHLLLLFKTAKSFKISKGMNILRDFKFGSIFSLLISGRLLRGWHQG 596

Query: 496 GQKYSDLRDIVDDFIAPSTFMKTILCVTSAFMPAIRSPS----------PINFLSSMFI- 544
           G  ++ L DI    +   +     + + S  +                  +  L+  F  
Sbjct: 597 GVNWTYLPDISKWLVQGGSGYVKWIQLISIILVIGLGLYTLFRTGSNRKGVRILAFGFST 656

Query: 545 -AFYKLMPIISKHLNELPIIASFDYTFFVRIIWSLLLISFLSKPTF---KQLRCQLSLFI 600
             F  L+  + ++ +EL     F  T  V++I+ LL IS +          L    S   
Sbjct: 657 CGFLVLLH-VGRYQDELS--TGFGATVTVKVIYYLLSISSIGASLVLPWSALNKDKSFLA 713

Query: 601 -----LLLTRLENMGLYLLYDIWQRTMPEEGTLASV------------------------ 631
                L L     +  + L     +     G +  +                        
Sbjct: 714 EVGDCLYLIGSAYILCWCLLQQLLQQPINSGPILLLLLQILAILCLSSSDFQVNEWVEIT 773

Query: 632 MYYVAEQVAFFSLGNSNSLATVDLSQAYTGLDSYNIFAVGILLFTSVFAGALWWCLHQP 690
             Y       F+LGNSN+LAT+D++ A+ G+ S++    GIL+F   +A  + + L   
Sbjct: 774 ALYYMGMAGHFALGNSNTLATIDVAGAFIGISSHSTILSGILMFMITYASPMLFLLSLV 832
>ref|NP_491097.1| (NM_058696) Y54E10BR.1.p [Caenorhabditis elegans]
          Length = 348

 Score =  343 bits (871), Expect = 9e-93
 Identities = 70/370 (18%), Positives = 125/370 (32%), Gaps = 47/370 (12%)

Query: 3   FAFFGIFWLQIFGSILFLLGFFPHKNDSTGKAMSNQF--SPPAVIDQVVFVMVDALRADF 60
           F    I    +    +F + +           +  QF  S  A   ++  +  D LR D 
Sbjct: 5   FLIASITVHLVLIYSIFDVYY----TSPLVHGIPPQFINSQEAPAKRIFIISADGLRYDT 60

Query: 61  VFSKSHNMPFTQSLLYNSTHGIGFSAFARSPTVTMPRLKALTTGTIPGFLDVLLNIAESD 120
                   P+  S + N   GI   + +  PT + P   A+  G      + +  +A+  
Sbjct: 61  FNKYPDKSPYLHS-IMNERKGIYGLSRSHIPTESRPGHVAIFAGIT----EDISAVAKGW 115

Query: 121 TGSSIEAQDSWVYQLNSFNKKIEFYGDDTWLKLFPS-----AFSKFEGTTSFFVSDYTEV 175
             + ++        + + +     +G    + LF       +FS       F   D + +
Sbjct: 116 KKNPVQFD-----SVFNRSSYSWMWGSPDIVNLFDDLPNAESFSYSADEEDFASKDASNL 170

Query: 176 DNNVTRNF---------DHALPSSLSHSWDALILHYLGVDHIGHLYGPSSPLLNIKLLEI 226
           D  V  +F         D AL   +        LH LG+D  GH   P S      +  +
Sbjct: 171 DKWVFEHFENFLETAKTDEALNDKMREQKSIFFLHLLGIDTNGHGNKPMSRQYIDNIKVV 230

Query: 227 DTIISRIYKYLQEYDEKTNTHSLIVLCGDHGMNEVGNHGGSSSGETTAALSLLFPSNELS 286
           D+ I ++   +  +    +  +  +   DHGM + G+HG  S  E            +  
Sbjct: 231 DSGIEKVQHLVDAF--FGDHKTAWLFTSDHGMTDWGSHGAGSDDEVLTPFVAWGAGVKQG 288

Query: 287 HINKPILNMDDNPYSILERVEQVDVVPTICLLLGIPIPKGNMGKVLSPVTELWKDTKTAK 346
                              + Q+D+ P I  L+G PIP  +MG +   +    K +    
Sbjct: 289 GPKL--------------DLNQIDLAPLISALIGCPIPVNSMGILPVQMMNS-KGSSYEF 333

Query: 347 MAALSNLFQL 356
            A  +N  Q+
Sbjct: 334 KAIEANFKQV 343
>gb|AAF57689.1| (AE003799) CG12263 gene product [Drosophila melanogaster]
          Length = 1077

 Score =  339 bits (861), Expect = 1e-91
 Identities = 103/425 (24%), Positives = 174/425 (40%), Gaps = 73/425 (17%)

Query: 1   MRFAFFGIF----WLQIFGSILFLLGFFPHKNDSTGKAMSNQFSPPAVID---------- 46
           M   +  +     +L   G +LF  GF   +   T  +   + S     +          
Sbjct: 1   MNLTYLFVLIWLAFLISSGVMLFSRGFLLARVSKTETSTCRRLSTNPNAEYVLTDEVVNE 60

Query: 47  -----------------QVVFVMVDALRADF-VFSKS--HNMPFTQSLL-------YNST 79
                            +V+ ++VDAL+ +F ++  +    +P+   L+        N  
Sbjct: 61  IFKDVNASSNLCLPQKSKVIVLVVDALKYEFGLYRANATDPLPYENKLVVLQELLQQNPD 120

Query: 80  HGIGFSAFARSPTVTMPRLKALTTGTIPGFLDVLLNIAESDTGSSIEAQDSWVYQLNSFN 139
           H       A  PT T+ RLK LTTG++P F+D+  N A  +       +D+ + Q+   +
Sbjct: 121 HARLMRFRADPPTTTLQRLKGLTTGSLPTFIDIGSNFASPE-----INEDNIIDQIVKND 175

Query: 140 KKIEFYGDDTWLKLFPSAFSKFEGTTSFFVSDYTEVDNNVTRNFDHALPSSLSHSWDALI 199
             + F GD TW  L+P  F +     SF + D   VDN + ++    L S     W  L+
Sbjct: 176 LPVVFLGDSTWTDLYPHRFKRSYSYPSFDIFDLDSVDNEILKHLPKELESK---DWQVLV 232

Query: 200 LHYLGVDHIGHLYGPSSPLLNIKLLEIDTIISRIYKYLQEYDEKTNTHSLIVLCGDHGMN 259
            H+LGVDH GH +GP    +  KL E++ +I  +   +       +  + +++ GDHGM 
Sbjct: 233 AHFLGVDHCGHKHGPMHEEMARKLGEMNEVIRSVVAAM-------DNDTTLLVMGDHGMT 285

Query: 260 EVGNHGGSSSGETTAALSLLFPSNELSHINKPILNMDDNPYSILERVEQVDVVPTICLLL 319
             G+HGG +  ET A L      +            +D+     E ++Q+D+VPT+  +L
Sbjct: 286 ASGDHGGDTDDETNALLFAYSKQHRF--------YGNDSGSDS-EMLQQIDLVPTLATIL 336

Query: 320 GIPIPKGNMGKVLSPVTELWKDTKTAKMAALSNLFQLSLLKNPSLTTSELSTQFQDSDLN 379
           G+PIP  N+G V      +  D +   +        L   +N +         F    L 
Sbjct: 337 GVPIPYSNLGLVN---FNIVPDLRVPHLNKF-QTLLLHSWQN-AQQIYRY---FFQYALE 388

Query: 380 DIRLA 384
           + R  
Sbjct: 389 NKRTF 393
 Score = 81.6 bits (200), Expect = 4e-14
 Identities = 13/60 (21%), Positives = 30/60 (49%), Gaps = 1/60 (1%)

Query: 696  RSVKTFWIMSSISLTFLCISCFIMRHHLFVWSVFSPKLLYNASWASMYFLAKCLISTIMV 755
            +    F+++  + +    ++C I   HL VW +F+P+ +Y A    +  L   ++  ++V
Sbjct: 999  KLATQFFMLQGLKIFCAMLACTIHCRHLMVWKIFAPRFIYEALATFV-SLPALIVGYLLV 1057
 Score = 42.7 bits (100), Expect = 0.024
 Identities = 22/156 (14%), Positives = 55/156 (35%), Gaps = 22/156 (14%)

Query: 546 FYKLMPIISKHLNE----LPIIASFDYTF-----FVRIIWSLLLISFLSKPTFKQLRCQL 596
           F K+  +     +E    +P++      +        +  +L++I  L +P         
Sbjct: 781 FRKMKRMYEGDDDERRSHIPVVYGLATVYSSIVIAFGVFLALVMI-VLLEPRASIGLVVC 839

Query: 597 SLFILLLTRLENMGLY----LLYDIWQRTMPEEGTLASVMYYVAEQVAFFSLGNSNSLAT 652
                +L  + ++  Y          Q T         V +++     FF+  +  +L+ 
Sbjct: 840 VAVGAILLSVHSILRYRTATSFESCVQPTFTA-----LVGWFLLAHFCFFATSHQTTLSQ 894

Query: 653 VDLSQAYTGLDS---YNIFAVGILLFTSVFAGALWW 685
           ++   A+ G  +    +    G L+  + F G +++
Sbjct: 895 IEWRAAFVGRTTGIGQSNLVSGALVILNTFCGPIFF 930
>dbj|BAB29186.1| (AK014165) data source:MGD, source key:MGI:1351629,
           evidence:ISS~phosphatidylinositol glycan, class
           N~putative [Mus musculus]
          Length = 320

 Score =  336 bits (855), Expect = 6e-91
 Identities = 62/316 (19%), Positives = 110/316 (34%), Gaps = 38/316 (12%)

Query: 3   FAFFGIFWLQIFGSILFLLGFFPHKNDSTGKAMSNQF-SPPAVIDQVVFVMVDALRADFV 61
           F   G+    +F + +F + F           M+ QF   P    ++V  + D LRAD +
Sbjct: 4   FFALGLLIHFVFFASIFDIYF----TSPLVHGMTPQFTPLPPPAKRLVLFVADGLRADTL 59

Query: 62  FSKSH----NMPFTQSLLYNSTHGIGFSAFARSPTVTMPRLKALTTGTIPGFLDVLLNIA 117
           +          PF ++++     G    +  R PT + P   AL  G    F + +  +A
Sbjct: 60  YELDEDGNSRAPFIRNVIM--HEGSWGVSHTRVPTESRPGHVALIAG----FYEDVSAVA 113

Query: 118 ESDTGSSIEAQDSWVYQLNSFNKKIEFYGDDTWLKLFPSA--------FSKFEGTTSFFV 169
           +    + +E+       L +  K    +G    L +F           +S       F  
Sbjct: 114 KGWKENPVESD-----SLFNERKYTWSWGSPDILPMFAKGASGDHVYTYSYDAQREDFGA 168

Query: 170 SDYTEVDNNVTRNFDH---------ALPSSLSHSWDALILHYLGVDHIGHLYGPSSPLLN 220
            D T++D  V               +L + ++       LH LG+D  GH + PSS    
Sbjct: 169 HDATKLDTWVFDKVKDFFDAARNNQSLFTKVNEEKVVFFLHLLGIDTNGHAHRPSSREYK 228

Query: 221 IKLLEIDTIISRIYKYLQEYDEKTNTHSLIVLCGDHGMNEVGNHGGSSSGETTAALSLLF 280
             + ++D  +  I    + +    +  +  +   DHGM + G+HG     ET        
Sbjct: 229 DNIKKVDDGVKEIVSIFKHFYG-DDGKTAFIFTSDHGMTDWGSHGAGHPSETLTPFVTWG 287

Query: 281 PSNELSHINKPILNMD 296
              +           D
Sbjct: 288 AGIKFPQNVSAQQYDD 303
>pir||T40715 hypothetical protein SPBC839.08c - fission yeast
           (Schizosaccharomyces pombe)
 emb|CAA17011.1| (AL021816) hypothetical protein [Schizosaccharomyces pombe]
 emb|CAB46701.1| (AL096796) hypothetical protein [Schizosaccharomyces pombe]
          Length = 935

 Score =  332 bits (843), Expect = 2e-89
 Identities = 77/408 (18%), Positives = 142/408 (33%), Gaps = 53/408 (12%)

Query: 2   RFAFFGIFWLQIFGSILFLLGFFPHKNDSTGKAMSNQFSPPAVIDQVVFVMVDALRADFV 61
           R    GI +  +F   +F + F           M    +  A   ++  ++ D LR D +
Sbjct: 4   RLLLLGILFHVVFLKSIFDIYF----VTPLIHGMKQYSAGEAPAKRLFLIVGDGLRPDKL 59

Query: 62  F----------SKSHNMPFTQSLLYNSTHGIGFSAFARSPTVTMPRLKALTTGTIPGFLD 111
                       +++  PF +S++ N  +G    +  R PT + P   AL  G    F +
Sbjct: 60  LQPHSEKVIGEEQTYAAPFLRSIIQN--NGTFGVSHTRVPTESRPGHVALIAG----FYE 113

Query: 112 VLLNIAESDTGSSIEAQDSWVYQLNSFNKKIEFYGDDTWLKLFPSAFSKFEGTTSF---- 167
            +  + +    + +     +    +        +G +  L +F    S      +F    
Sbjct: 114 DVSAVTKGWKKNPVNFDSVFNQSRH-----TYSFGSEDILPMFSEGASDPSRVDTFMYSS 168

Query: 168 ----FVSDYTEVDNNVTRNFDHALPSSLSH---------SWDALILHYLGVDHIGHLYGP 214
               F S+   +D  V    D  L  SL                 LH LG+D IGH   P
Sbjct: 169 ELEDFSSNGIVLDEWVFDRLDELLAQSLEDKELWDMLHRDKIVFFLHLLGIDTIGHNKHP 228

Query: 215 SSPLLNIKLLEIDTIISRIYKYLQEYDEKTNTHSLIVLCGDHGMNEVGNHGGSSSGETTA 274
            S      +  ID  I  +   +  Y    +  S  V   DHGM++ G+HG  +   T  
Sbjct: 229 DSVEYVENIQYIDGKIQELVDKMNNYY-NNDGASSWVFTADHGMSDFGSHGDGNLDNTRT 287

Query: 275 ALSLLFPSNELSHINKPIL---NMDDNPYSILE--RVEQVDVVPTICLLLGIPIPKGNMG 329
            +       +     K             + ++   ++Q D+   +  L+G+  P  ++G
Sbjct: 288 PIIAWGAGIQSPTHEKNYGHDEYSLPWNLTEIKRIDIQQADIAALMSYLVGLNFPVNSVG 347

Query: 330 KVLSPVTELWKDTKTAKMAALSNLFQLSLLKNPSLTTSELSTQFQDSD 377
           ++  P+  L   ++     AL N   L + +  +L ++    Q     
Sbjct: 348 QI--PLDYLDCSSRRKAEVALMNA--LEIGEQYNLKSAS-KDQTSIFF 390
>gb|AAF59557.2| (AC024812) Hypothetical protein Y54E10BR.1 [Caenorhabditis elegans]
          Length = 929

 Score =  327 bits (831), Expect = 4e-88
 Identities = 71/370 (19%), Positives = 125/370 (33%), Gaps = 47/370 (12%)

Query: 3   FAFFGIFWLQIFGSILFLLGFFPHKNDSTGKAMSNQF--SPPAVIDQVVFVMVDALRADF 60
           F    I    +    +F + +           +  QF  S  A   ++  +  D LR D 
Sbjct: 5   FLIASITVHLVLIYSIFDVYY----TSPLVHGIPPQFINSQEAPAKRIFIISADGLRYDT 60

Query: 61  VFSKSHNMPFTQSLLYNSTHGIGFSAFARSPTVTMPRLKALTTGTIPGFLDVLLNIAESD 120
                   P+  S + N   GI   + +  PT + P   A+  G      + +  +A+  
Sbjct: 61  FNKYPDKSPYLHS-IMNERKGIYGLSRSHIPTESRPGHVAIFAGIT----EDISAVAKGW 115

Query: 121 TGSSIEAQDSWVYQLNSFNKKIEFYGDDTWLKLFPS-----AFSKFEGTTSFFVSDYTEV 175
             + ++        + + +     +G    + LF       +FS       F   D + +
Sbjct: 116 KKNPVQFD-----SVFNRSSYSWMWGSPDIVNLFDDLPNAESFSYSADEEDFASKDASNL 170

Query: 176 DNNVTRNF---------DHALPSSLSHSWDALILHYLGVDHIGHLYGPSSPLLNIKLLEI 226
           D  V  +F         D AL   +        LH LG+D  GH   P S      +  +
Sbjct: 171 DKWVFEHFENFLETAKTDEALNDKMREQKSIFFLHLLGIDTNGHGNKPMSRQYIDNIKVV 230

Query: 227 DTIISRIYKYLQEYDEKTNTHSLIVLCGDHGMNEVGNHGGSSSGETTAALSLLFPSNELS 286
           D+ I ++   +  +    +  +  +   DHGM + G+HG  S  E            +  
Sbjct: 231 DSGIEKVQHLVDAF--FGDHKTAWLFTSDHGMTDWGSHGAGSDDEVLTPFVAWGAGVKQG 288

Query: 287 HINKPILNMDDNPYSILERVEQVDVVPTICLLLGIPIPKGNMGKVLSPVTELWKDTKTAK 346
                              + Q+D+ P I  L+G PIP  +MG +   +    K +    
Sbjct: 289 GPKL--------------DLNQIDLAPLISALIGCPIPVNSMGILPVQMMNS-KGSSYEF 333

Query: 347 MAALSNLFQL 356
            A  +N  QL
Sbjct: 334 KAIEANFKQL 343
>pir||T40030 hypothetical protein SPBC27B12.06 - fission yeast
           (Schizosaccharomyces pombe)
 dbj|BAA21454.1| (AB004539) ORF YLL031c [Schizosaccharomyces pombe]
 emb|CAA16901.1| (AL021766) hypothetical protein [Schizosaccharomyces pombe]
          Length = 918

 Score =  323 bits (822), Expect = 4e-87
 Identities = 110/410 (26%), Positives = 171/410 (40%), Gaps = 57/410 (13%)

Query: 4   AFFGIFWLQIFGSILFLLGFFPHKNDSTGKAMSNQFS-------------PPAVIDQVVF 50
            F  I     +G   F  GF   +      ++                   P + ++ V 
Sbjct: 27  FFAIILISNFYGLKSFTDGFLLRRAVLNQTSLCENPPADVREWKNSSGCWAPKIFERAVI 86

Query: 51  VMVDALRADFVFSKSHNMPFTQSLLY-------NSTHGIGFSAFARSPTVTMPRLKALTT 103
           V++DALR DF+   + +  +  +          +  +       A +PT T  RLK LTT
Sbjct: 87  VIIDALRYDFLIPYNDSNYYHNAFTTPYETSVLHPENSYLTQFIADAPTTTSQRLKGLTT 146

Query: 104 GTIPGFLDVLLNIAESDTGSSIEAQDSWVYQLNSFNKKIEFYGDDTWLKLFPSAFSK--F 161
           G++P F+D+  N A ++       +D+ + Q  S +K+I   GDDTW  LF    ++   
Sbjct: 147 GSLPTFIDLGSNFAGTN-----IDEDNLLLQWKSLDKQIVLLGDDTWDVLFHDYLNETLS 201

Query: 162 EGTTSFFVSDYTEVDNN----VTRNFDHALPSSLSHSWDALILHYLGVDHIGHLYGPSSP 217
           +   SF V D   VDN     V      A         D LI HYLGVDH+GH  GP  P
Sbjct: 202 QPAFSFNVPDLHGVDNKVNQYVFDYIKDANF-------DVLIAHYLGVDHVGHRLGPDHP 254

Query: 218 LLNIKLLEIDTIISRIYKYLQEYDEKTNTHSLIVLCGDHGMNEVGNHGGSSSGETTAALS 277
            +  KL ++D  +  +   L       +  +L+++ GDHGM+  GNHGG S  E  + L 
Sbjct: 255 TMRDKLNQMDRCVKEMMDLL-------DDSTLLIVMGDHGMDNKGNHGGDSFDEINSVLW 307

Query: 278 LLFPSNELSHINKPILNMDDNPYSILERVEQVDVVPTICLLLGIPIPKGNMGKVLSPVTE 337
           +        ++ +P   +            QVD+VPT+ LLLG PIP GN+G ++     
Sbjct: 308 MYSKKPTFGYLKQPGKVLS---------ANQVDLVPTLSLLLGNPIPYGNLGTLIPEPFY 358

Query: 338 LWKDTKTAKMAALSNLFQLSLLKNPSLTTSELSTQFQDSDLNDIRLALEN 387
            +   +    A   N+ QL   +  S    + S     S   +    L+ 
Sbjct: 359 YY-GDEYLSKAQKINIGQL--NRFFSEYDLDASDFLSSSVHKNNNSYLDQ 405
 Score =  295 bits (749), Expect = 2e-78
 Identities = 59/383 (15%), Positives = 117/383 (30%), Gaps = 73/383 (19%)

Query: 408 ISILGACSILSLILFRNLYNYKELLAFAPFVVQNIIIVFSSSFIEEEHVIWYFAAVSLSL 467
           I+I              L+      A A  ++Q +I  + ++  EE+     F   +   
Sbjct: 553 ITIGLVMFCKCFSEMSPLFACSTYSALAFILLQ-VISSYVTNCREEQGA---FCVST--- 605

Query: 468 LQLLNPKTRLAGSLQLFCLSIIKRWNQTGQKYSDLRDIVDDFIAPSTFMKTILCV--TSA 525
             +  P   L   + L  +++                     I P      +  V   S 
Sbjct: 606 -YISTPDNSLRTLIVLALMAL------------------SSIILPLILQLHLRRVLGLSL 646

Query: 526 FMPAIRSPSPINFLSSMFIAFYKLMPIISKHLNEL-----PIIASFDYTFFVRI----IW 576
            +  +        +SS+F     +   +  +   L      ++ S   T+ + I    IW
Sbjct: 647 KLYHLSILYFFELISSIFW----IAHHVFANDALLEKQYHHVLYSLANTYVICILGVLIW 702

Query: 577 SLLLISFLSKPTFKQL------RCQLSLFILLLTRLENMGLYLLYDIW----------QR 620
              L+S         +         L  F+  L R   +G   L+  +          Q 
Sbjct: 703 QFFLLSRSKFAKINVIERSYFVFALLYSFLSFLQRP--LGHLSLFSCFLQILLLIQLKQW 760

Query: 621 TMPEEGTLASVMYYVAEQVAFFSLGNSNSLATVDLSQAY-TGLDSYNIFAVGILLFTSVF 679
                    SV   +     FF+ GN  +++++D + A+     + N     I +F    
Sbjct: 761 QPSVGHNFFSVTLGLLGLSHFFTTGNQAAISSLDWNFAFIHSKSAENQAISAIFMFLHTV 820

Query: 680 AGALWWCLHQPK---RMMDRSV----------KTFWIMSSISLTFLCISCFIMRHHLFVW 726
              +  C+  P      + +             +F + + +  T         R HL VW
Sbjct: 821 GAPILTCISIPLFSFEPLSKKNRFLINLFRFSFSFILYNLLISTSTVFFAGFFRRHLMVW 880

Query: 727 SVFSPKLLYNASWASMYFLAKCL 749
            VF+P+ + +      + L   +
Sbjct: 881 KVFAPRFMLSGILLVTHQLFVLI 903
>gb|AAF58853.1| (AE003831) CG2292 gene product [Drosophila melanogaster]
          Length = 874

 Score =  299 bits (760), Expect = 9e-80
 Identities = 80/393 (20%), Positives = 131/393 (32%), Gaps = 57/393 (14%)

Query: 4   AFFGIFWLQIFGSILF----LLGFFPHKNDSTGKAMSNQFSPPAVIDQVVFVMVDALRAD 59
               +  L     I F    + G  P K+          +      +++V ++ D  RAD
Sbjct: 7   LVVHVLLLGSIFVIYFRSPVITGLTPQKHLL-------YYGLEPPANRLVLIVTDGFRAD 59

Query: 60  FVFSKSHNMPFTQSLLY-NSTHGIGFSAFARSPTVTMPRLKALTTGTIPGFLDVLLNIAE 118
             F    N  +  +L       G+   +  R PT T P    L  G      +    +  
Sbjct: 60  SFFE--ENCRYVPNLRKIFLREGVVGVSRTRVPTETRPGHITLIAGLY----EDPSAVLR 113

Query: 119 SDTGSSIEAQDSWVYQLNSFNKKIEFYGDDTWLKLFPSAFSKFEGTTSFFVSDYT----- 173
               + I+        + + + +   +G +  L +F    +  E    F+  D       
Sbjct: 114 GWKSNPIDFD-----TVFNRSSQTYAWGANDVLNVFSHVSNGGEINLRFYNHDLDFSPGY 168

Query: 174 ---EVDNNVTRNFDHALPSS----LSHSWDALILHYLGVDHIGHLYGPSSPLLNIKLLEI 226
              E D  V +     L                LH LG+D  GH++ P +P     L + 
Sbjct: 169 DAYEEDEWVFKRVKLLLQQKREALQRAQNVVFFLHLLGLDTAGHVHKPGAPKFRRTLEKT 228

Query: 227 DTIISRIYKYLQEYDEKTNTHSLIVLCGDHGMNEVGNHGGSSSGETTAALSLLFPSNELS 286
           +  +  IY+  +      +  +  +L  DHGM +     G+S            P+NE  
Sbjct: 229 EKGVYAIYQEFER--VFPDKRTAYLLTADHGMTD----SGASRAVPKPGGRTFMPNNE-- 280

Query: 287 HINKPILNMDDNPYSILERVEQVDVVPTICLLLGIPIPKGNMGKVLSPVTELWKDTKTAK 346
                       P   L  +EQ  + P +  LLG+  P  N GK+  P+  L    +   
Sbjct: 281 -----------GPAMPLHELEQAQLTPLMSALLGLAPPMNNFGKL--PLGYLNVSKEYEA 327

Query: 347 MAALSNLFQLSLLKNPSLTTSELSTQFQDSDLN 379
           MAA  N  QL L +  +L        F D  L 
Sbjct: 328 MAAHVNALQL-LEQYVALQKQHKKGFFADILLE 359
>ref|NP_491750.1| (NM_059349) C27A12.9.p [Caenorhabditis elegans]
 gb|AAB93646.1| (AF003137) Hypothetical protein C27A12.9 [Caenorhabditis elegans]
          Length = 905

 Score =  296 bits (752), Expect = 8e-79
 Identities = 104/367 (28%), Positives = 164/367 (44%), Gaps = 69/367 (18%)

Query: 7   GIFWLQIFGSILFLL--GFFP-HKNDSTGKAMSNQFSPP-------AVIDQVVFVMVDAL 56
            +         LF+   GF    +   +  + S+  + P           +V+ ++VDAL
Sbjct: 7   ILLVSINILLALFIFQNGFLLKRQEILSKSSCSDAHAQPGQTCWMKQQYQRVILILVDAL 66

Query: 57  RADFVFSKSHNMP------FTQSLLYN------STHGIGFSAFARSPTVTMPRLKALTTG 104
           R DF+     N        + +  + N      S +    +  A  PT T+ RLKALTTG
Sbjct: 67  RYDFLIPIDENTKKSKEEWYYRGQMKNIEKLVKSGNVSIGTLLADPPTTTLQRLKALTTG 126

Query: 105 TIPGFLDVLLNIAESDTGSSIEAQDSWVYQLNSFNKKIEFYGDDTWLKLFPSAFSKFEGT 164
           T+P F+D   N +      ++ ++DS+VYQ     K +   GDDTWL LFP+ FSK    
Sbjct: 127 TLPTFIDAGDNFSPD----AVISEDSFVYQAAQLGKNVTLLGDDTWLSLFPNQFSKTAAY 182

Query: 165 TSFFVSDYTEVDNNVTRNF---------------DHALPSSLSHSWDALILHYLGVDHIG 209
            SF ++D   VD+ + R                        L+ +   +I H+LGVDH G
Sbjct: 183 DSFDINDLNTVDDKIARKIFFGKYYNKMVFCFEGPILQDEMLNSNSSIIIAHFLGVDHCG 242

Query: 210 HLYGPSSPLLNIKLLEIDTIISRIYKYLQEYDEKTNTHSLIVLCGDHGMNEVGNHGGSSS 269
           H +GPS P++   L ++D II +  + ++                DHGM   G+HGG S 
Sbjct: 243 HKFGPSHPVMADTLRKMDRIIGQTIETMKSD--------------DHGMTSTGDHGGESE 288

Query: 270 GETTAALSLLFPSNELSHINKPILNMDDNPYSILERVEQVDVVPTICLLLGIPIPKGNMG 329
            E  A + +    +++    +PI               Q+D+VPTI LL+G+PIP  N+G
Sbjct: 289 NEIRAGILVHSKKHQIILPERPIH--------------QIDIVPTISLLMGLPIPFSNLG 334

Query: 330 KVLSPVT 336
            V++ + 
Sbjct: 335 TVITQLF 341
 Score =  121 bits (302), Expect = 5e-26
 Identities = 22/116 (18%), Positives = 51/116 (43%), Gaps = 12/116 (10%)

Query: 640 AFFSLGNSNSLATVDLSQAYTGL---DSYNIFAVGILLFTSVFA--GALWWCLHQPKRMM 694
            F+ LG+S  ++++  + A+ G+    +  +     +LF   F+   +++    + +   
Sbjct: 761 GFYHLGHSPVISSIPWNAAFVGIPGGTALRVLPALFVLFHLNFSAISSIFVISSESESSQ 820

Query: 695 DRS-------VKTFWIMSSISLTFLCISCFIMRHHLFVWSVFSPKLLYNASWASMY 743
             S       +    ++ +I  T  C+   I R HL VW +F+PK ++      ++
Sbjct: 821 KMSAPNTAWTLTETLVLMTIRATLTCLVSSIHRRHLMVWKIFAPKFIFECILTIVF 876
>dbj|BAB55130.1| (AK027465) unnamed protein product [Homo sapiens]
          Length = 549

 Score =  266 bits (675), Expect = 8e-70
 Identities = 81/322 (25%), Positives = 136/322 (42%), Gaps = 46/322 (14%)

Query: 481 LQLFCLSIIKRWNQTGQKYSDLRDI-----VDDFIAPSTFMKTILCVTSAFMPAIRSPSP 535
           L L C  +++  NQTG +++   D+       D  A  + +  +  +    +   R  SP
Sbjct: 226 LILACCRLLRSLNQTGVQWAHRPDLGHWLTSSDHKAELSVLAALSLLVVFVLVQ-RGCSP 284

Query: 536 IN--FLSSMFIAFYKLMPII----------SKHLNELPIIASFDYTFFVRIIWS---LLL 580
           ++   L+   +  Y     I          SK +++  I A F Y F + I+++    LL
Sbjct: 285 VSKAALALGLLGVYCYRAAIGSVRFPWRPDSKDISKGIIEARFVYVFVLGILFTGTKDLL 344

Query: 581 ISFLSKPTFK-------QLRCQLSLFILLLTRLENMGLYLLYDIWQRTMPE--------E 625
            S +    FK       ++   L L   LL R  N+ +     + Q  M +        +
Sbjct: 345 KSQVIAADFKLKTVGLWEIYSGLVLLAALLFRPHNLPVLAFSLLIQTLMTKFIWKPLRHD 404

Query: 626 GTLASVMYYVAEQVAFFSLGNSNSLATVDLSQAYTGLDSYNIFAVGILLFTSVFAGALWW 685
               +VM+Y   Q  F+  GNSN++ATVD+S  + GLD+Y      +L     +AG + W
Sbjct: 405 AAEITVMHYWFGQAFFYFQGNSNNIATVDISAGFVGLDTYVEIPAVLLTAFGTYAGPVLW 464

Query: 686 CLHQPK---------RMMDRSVKTFWIMSSISLTFLCISCFIMRHHLFVWSVFSPKLLYN 736
             H              +  +   + ++ SI +    +    +R+HLF+WSVFSPKLLY 
Sbjct: 465 ASHLVHFLSSETRSGSALSHACFCYALICSIPVFTYIVLVTSLRYHLFIWSVFSPKLLYE 524

Query: 737 ASWASMYFLAKCLISTIMVRLR 758
                +   A C+  T M + R
Sbjct: 525 GMHLLITA-AVCVFFTAMDQTR 545
 Score = 37.6 bits (87), Expect = 0.73
 Identities = 11/46 (23%), Positives = 22/46 (46%), Gaps = 4/46 (8%)

Query: 424 NLYNYKELLAFAPFVVQ----NIIIVFSSSFIEEEHVIWYFAAVSL 465
            ++           ++     +++ + +SSF+EEEH  WYF   +L
Sbjct: 106 PMHPSSRWSELDLLILLGTAGHVLSLGASSFVEEEHQTWYFLVNTL 151
>ref|NP_060203.1| (NM_017733) hypothetical protein FLJ20265 [Homo sapiens]
 dbj|BAA91046.1| (AK000272) unnamed protein product [Homo sapiens]
 gb|AAH01249.1|AAH01249 (BC001249) hypothetical protein FLJ20265 [Homo sapiens]
          Length = 604

 Score =  266 bits (675), Expect = 8e-70
 Identities = 81/322 (25%), Positives = 136/322 (42%), Gaps = 46/322 (14%)

Query: 481 LQLFCLSIIKRWNQTGQKYSDLRDI-----VDDFIAPSTFMKTILCVTSAFMPAIRSPSP 535
           L L C  +++  NQTG +++   D+       D  A  + +  +  +    +   R  SP
Sbjct: 281 LILACCRLLRSLNQTGVQWAHRPDLGHWLTSSDHKAELSVLAALSLLVVFVLVQ-RGCSP 339

Query: 536 IN--FLSSMFIAFYKLMPII----------SKHLNELPIIASFDYTFFVRIIWS---LLL 580
           ++   L+   +  Y     I          SK +++  I A F Y F + I+++    LL
Sbjct: 340 VSKAALALGLLGVYCYRAAIGSVRFPWRPDSKDISKGIIEARFVYVFVLGILFTGTKDLL 399

Query: 581 ISFLSKPTFK-------QLRCQLSLFILLLTRLENMGLYLLYDIWQRTMPE--------E 625
            S +    FK       ++   L L   LL R  N+ +     + Q  M +        +
Sbjct: 400 KSQVIAADFKLKTVGLWEIYSGLVLLAALLFRPHNLPVLAFSLLIQTLMTKFIWKPLRHD 459

Query: 626 GTLASVMYYVAEQVAFFSLGNSNSLATVDLSQAYTGLDSYNIFAVGILLFTSVFAGALWW 685
               +VM+Y   Q  F+  GNSN++ATVD+S  + GLD+Y      +L     +AG + W
Sbjct: 460 AAEITVMHYWFGQAFFYFQGNSNNIATVDISAGFVGLDTYVEIPAVLLTAFGTYAGPVLW 519

Query: 686 CLHQPK---------RMMDRSVKTFWIMSSISLTFLCISCFIMRHHLFVWSVFSPKLLYN 736
             H              +  +   + ++ SI +    +    +R+HLF+WSVFSPKLLY 
Sbjct: 520 ASHLVHFLSSETRSGSALSHACFCYALICSIPVFTYIVLVTSLRYHLFIWSVFSPKLLYE 579

Query: 737 ASWASMYFLAKCLISTIMVRLR 758
                +   A C+  T M + R
Sbjct: 580 GMHLLITA-AVCVFFTAMDQTR 600
 Score = 37.6 bits (87), Expect = 0.73
 Identities = 11/46 (23%), Positives = 22/46 (46%), Gaps = 4/46 (8%)

Query: 424 NLYNYKELLAFAPFVVQ----NIIIVFSSSFIEEEHVIWYFAAVSL 465
            ++           ++     +++ + +SSF+EEEH  WYF   +L
Sbjct: 161 PMHPSSRWSELDLLILLGTAGHVLSLGASSFVEEEHQTWYFLVNTL 206
>ref|NP_194699.1| (NM_119115) nucleotide pyrophosphatase -like protein [Arabidopsis
           thaliana]
 pir||T09933 nucleotide pyrophosphatase homolog T16L4.210 - Arabidopsis thaliana
 emb|CAB45330.1| (AL079344) nucleotide pyrophosphatase-like protein [Arabidopsis
           thaliana]
 emb|CAB79728.1| (AL161575) nucleotide pyrophosphatase-like protein [Arabidopsis
           thaliana]
          Length = 461

 Score =  266 bits (674), Expect = 1e-69
 Identities = 56/280 (20%), Positives = 102/280 (36%), Gaps = 34/280 (12%)

Query: 6   FGIFWLQIFGS--ILFLLGFFPHKNDSTGK----AMSNQFSPPAVIDQV-----VFVMVD 54
              F L +     I  +         + G     +  ++   P    ++     + +  D
Sbjct: 7   VISFKLSLIFLLNIFIVATIAAAAAVNAGTKGLDSRPSKTRRPWPFKKLNKPVVLMISCD 66

Query: 55  ALRADFVFSKSHNMPFTQSLLYNSTHGIGFSAFARSPTVTMPRLKALTTGTIPGFLDVLL 114
             R  + F      P    L+   T           PT+T P   ++ TG  P +  +++
Sbjct: 67  GFRFGYQFKTD--TPNIDLLISGGTEAKHGLIPV-FPTMTFPNHYSIATGLYPAYHGIIM 123

Query: 115 N-IAESDTGSSIE---------AQDSWVYQLNSFNKKIEFYGDDTWLKLFPSAFSKFEGT 164
           N   +  TG              +  WV  +N   K + ++   + +    S+++  EG 
Sbjct: 124 NKFTDPVTGEVFNKGLQPKWWLGEPLWVTAVNQGLKAVTYFWPGSEV--LKSSWTCPEGY 181

Query: 165 TSFF--VSDYTEVDNNVTRNFDHALPSSLSHSWDALILHYLGVDHIGHLYGPSSPLLNIK 222
              F       E  ++V  +FDH          D L+L++   D  GH YGP  P +   
Sbjct: 182 CPHFNLSVPLEERVDSVLSHFDHL----EDEVPDLLMLYFDEPDQSGHNYGPDDPRVTTA 237

Query: 223 LLEIDTIISRIYKYLQEYDEKTNTHSLIVLCGDHGMNEVG 262
           +  +D +I R+ K L++ +     H  ++L GDHGM    
Sbjct: 238 VSRVDKMIGRVIKGLKQREIFDEVH--VILLGDHGMVTNC 275
>gb|AAK25979.1|AF360269_1 (AF360269) putative nucleotide pyrophosphatase [Arabidopsis
           thaliana]
          Length = 456

 Score =  264 bits (670), Expect = 3e-69
 Identities = 55/275 (20%), Positives = 101/275 (36%), Gaps = 33/275 (12%)

Query: 10  WLQIFGSILFLLGFFPHKNDSTGK-----AMSNQFSPPAVIDQV-----VFVMVDALRAD 59
           +L     I F++                 +  ++   P    ++     + +  D  R  
Sbjct: 7   FLSSSFLIFFIVATIAAAAAVNAGTKGLDSRPSKTRRPWPFKKLNKPVVLMISCDGFRFG 66

Query: 60  FVFSKSHNMPFTQSLLYNSTHGIGFSAFARSPTVTMPRLKALTTGTIPGFLDVLLN-IAE 118
           + F      P    L+   T           PT+T P   ++ TG  P +  +++N   +
Sbjct: 67  YQFKTD--TPNIDLLISGGTEAKHGLIPV-FPTMTFPNHYSIATGLYPAYHGIIMNKFTD 123

Query: 119 SDTGSSIE---------AQDSWVYQLNSFNKKIEFYGDDTWLKLFPSAFSKFEGTTSFF- 168
             TG              +  WV  +N   K + ++   + +    S+++  EG    F 
Sbjct: 124 PVTGEVFNKGLQPKWWLGEPLWVTAVNQGLKAVTYFWPSSEV--LKSSWTCPEGYCPHFN 181

Query: 169 -VSDYTEVDNNVTRNFDHALPSSLSHSWDALILHYLGVDHIGHLYGPSSPLLNIKLLEID 227
                 E  ++V  +FDH          D L+L++   D  GH YGP  P +   +  +D
Sbjct: 182 LSVPLEERVDSVLSHFDHL----EDEVPDLLMLYFDEPDQSGHNYGPDDPRVTTAVSRVD 237

Query: 228 TIISRIYKYLQEYDEKTNTHSLIVLCGDHGMNEVG 262
            +I R+ K L++ +     H  ++L GDHGM    
Sbjct: 238 KMIGRVIKGLKQREIFDEVH--VILLGDHGMVTNC 270
>ref|NP_005012.1| (NM_005021) ectonucleotide pyrophosphatase/phosphodiesterase 3;
           phosphodiesterase I/nucleotide pyrophosphatase 3;
           phosphodiesterase-I beta; gp130RB13-6; bovine intestinal
           phosphodiesterase [Homo sapiens]
 gb|AAC51813.1| (AF005632) phosphodiesterase I/nucleotide pyrophosphatase beta
           [Homo sapiens]
          Length = 875

 Score =  262 bits (665), Expect = 1e-68
 Identities = 45/250 (18%), Positives = 88/250 (35%), Gaps = 34/250 (13%)

Query: 29  DSTGKAMSNQFSPPAVIDQVVFVMVDALRADFVFSKSHNMPFTQSLLYNSTHGIGFSAFA 88
            +        F  P     V+   +D  RA+++++    MP    L     H     A  
Sbjct: 146 TAQQSQCPEGFDLPP----VILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAM- 200

Query: 89  RSPTVTMPRLKALTTGTIPGFLDVLLN------------IAESDTGSSIEA--QDSWVYQ 134
             PT T P    + TG  P    ++ N            ++  +  +      Q  W+  
Sbjct: 201 -YPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTA 259

Query: 135 LNSFNKKIEFYGDDTWLKL---FPSAFSKFEGTTSFFVSDYTEVDNNVTRNFDHALPSSL 191
           +    K   ++   + + +   FPS +  + G        + E  + + +  D  LP + 
Sbjct: 260 MYQGLKAATYFWPGSEVAINGSFPSIYMPYNG-----SVPFEERISTLLKWLD--LPKAE 312

Query: 192 SHSWDALILHYLGVDHIGHLYGPSSPLLNIKLLEIDTIISRIYKYLQEYDEKTNTHSLIV 251
                   +++   D  GH  GP S  +   L  +D     + + L++ +     +  I+
Sbjct: 313 RPR--FYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVN--II 368

Query: 252 LCGDHGMNEV 261
           L  DHGM++ 
Sbjct: 369 LLADHGMDQT 378
>ref|NP_194698.1| (NM_119114) nucleotide pyrophosphatase - like protein [Arabidopsis
           thaliana]
 pir||T09932 nucleotide pyrophosphatase homolog T16L4.200 - Arabidopsis thaliana
 emb|CAB45329.1| (AL079344) nucleotide pyrophosphatase-like protein [Arabidopsis
           thaliana]
 emb|CAB79727.1| (AL161575) nucleotide pyrophosphatase-like protein [Arabidopsis
           thaliana]
          Length = 457

 Score =  260 bits (658), Expect = 9e-68
 Identities = 51/271 (18%), Positives = 98/271 (35%), Gaps = 30/271 (11%)

Query: 12  QIFGSILFLLGFFPHKNDSTGK-AMSNQFSPPAVIDQV-----VFVMVDALRADFVFSKS 65
            ++   L +L        + G  + S+    P    ++     + +  D  R  + F   
Sbjct: 15  ILYKLSLTVLIVLSVAVTANGSDSPSSYVRRPQPPKKLNKPVVLLISCDGFRFGYQF--K 72

Query: 66  HNMPFTQSLLYNSTHGIGFSAFARSPTVTMPRLKALTTGTIPGFLDVLLN-IAESDTGSS 124
              P    L+   T           PT+T P   ++ TG  P    +++N   +  +G  
Sbjct: 73  TETPNIDLLISRGTEAKTGLIPV-FPTMTFPNHYSIATGLYPASHGIIMNKFTDPVSGEL 131

Query: 125 IE---------AQDSWVYQLNSFNKKIEFYGDDTWLKLFPSAFSKFEGTT--SFFV-SDY 172
                       +  WV  +N       ++     +     +++  +G     + V    
Sbjct: 132 FNRNLNPKWWLGEPLWVTAVNQGLMAATYFWPGADV--HKGSWNCPKGFCKAPYNVSVPL 189

Query: 173 TEVDNNVTRNFDHALPSSLSHSWDALILHYLGVDHIGHLYGPSSPLLNIKLLEIDTIISR 232
            E  + +   FD  LP       D + L++   D  GH YGP  P +   + ++D +I R
Sbjct: 190 EERVDTILNYFD--LP--EREIPDFMALYFDEPDIQGHEYGPDDPRVTEAVSKVDKMIGR 245

Query: 233 IYKYLQEYDEKTNTHSLIVLCGDHGMNEVGN 263
           I   L++    ++ H  ++L GDHGM    +
Sbjct: 246 IIMGLEKRKVFSDVH--VILLGDHGMVTNCD 274
>dbj|BAA02053.1| (D12485) The first in-frame ATG codon is located at nucleotides
           17-19, followed by a second ATG codon 52 codons
           downstream. And the second ATG codon is potential
           initiation point for translation of NPPase. [Homo
           sapiens]
          Length = 930

 Score =  258 bits (655), Expect = 2e-67
 Identities = 45/247 (18%), Positives = 82/247 (32%), Gaps = 34/247 (13%)

Query: 29  DSTGKAMSNQFSPPAVIDQVVFVMVDALRADFVFSKSHNMPFTQSLLYNSTHGIGFSAFA 88
                     F  P      +   +D  RA+++ +    +P    L    T+        
Sbjct: 202 SINEPQCPAGFETPP----TLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMR--P 255

Query: 89  RSPTVTMPRLKALTTGTIPGFLDVLLN-IAESDTGSSI-------------EAQDSWVYQ 134
             PT T P   ++ TG  P    ++ N + +    +S              + +  WV  
Sbjct: 256 VYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTA 315

Query: 135 LNSFNKKIEFYGDDTWLK---LFPSAFSKFEGTTSFFVSDYTEVDNNVTRNFDHALPSSL 191
                K   F+   + ++   +FP  +  + G        + E    V +     LP   
Sbjct: 316 KYQGLKSGTFFWPGSDVEINGIFPDIYKMYNG-----SVPFEERILAVLQWL--QLPKDE 368

Query: 192 SHSWDALILHYLGVDHIGHLYGPSSPLLNIKLLEIDTIISRIYKYLQEYDEKTNTHSLIV 251
                   L+    D  GH YGP S  +   L  +D ++  +   L+E +     +  ++
Sbjct: 369 RPH--FYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLN--LI 424

Query: 252 LCGDHGM 258
           L  DHGM
Sbjct: 425 LISDHGM 431
>pir||A39216 plasma cell membrane glycoprotein PC-1 - human
 gb|AAF36094.1| (AF110304) PDNP1 [Homo sapiens]
 emb|CAC39442.1| (AJ242020) plasma cell membrane glycoprotein [Homo sapiens]
          Length = 925

 Score =  258 bits (654), Expect = 3e-67
 Identities = 45/247 (18%), Positives = 82/247 (32%), Gaps = 34/247 (13%)

Query: 29  DSTGKAMSNQFSPPAVIDQVVFVMVDALRADFVFSKSHNMPFTQSLLYNSTHGIGFSAFA 88
                     F  P      +   +D  RA+++ +    +P    L    T+        
Sbjct: 197 SINEPQCPAGFETPP----TLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMR--P 250

Query: 89  RSPTVTMPRLKALTTGTIPGFLDVLLN-IAESDTGSSI-------------EAQDSWVYQ 134
             PT T P   ++ TG  P    ++ N + +    +S              + +  WV  
Sbjct: 251 VYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTA 310

Query: 135 LNSFNKKIEFYGDDTWLK---LFPSAFSKFEGTTSFFVSDYTEVDNNVTRNFDHALPSSL 191
                K   F+   + ++   +FP  +  + G        + E    V +     LP   
Sbjct: 311 KYQGLKSGTFFWPGSDVEINGIFPDIYKMYNG-----SVPFEERILAVLQWL--QLPKDE 363

Query: 192 SHSWDALILHYLGVDHIGHLYGPSSPLLNIKLLEIDTIISRIYKYLQEYDEKTNTHSLIV 251
                   L+    D  GH YGP S  +   L  +D ++  +   L+E +     +  ++
Sbjct: 364 RPH--FYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLN--LI 419

Query: 252 LCGDHGM 258
           L  DHGM
Sbjct: 420 LISDHGM 426
>ref|NP_006199.1| (NM_006208) ectonucleotide pyrophosphatase/phosphodiesterase 1;
           phosphodiesterase I/nucleotide pyrophosphatase 1
           (homologous to mouse Ly-41 antigen); plasma-cell
           membrane glycoprotein [Homo sapiens]
 sp|P22413|PC1_HUMAN ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE 1 (PLASMA-CELL
           MEMBRANE GLYCOPROTEIN PC-1) [INCLUDES: ALKALINE
           PHOSPHODIESTERASE I ; NUCLEOTIDE PYROPHOSPHATASE
           (NPPASE)]
 gb|AAA63237.1| (M57736) plasma cell membrane glycoprotein PC-1 [Homo sapiens]
 dbj|BAA02054.1| (D12485) NPPase [Homo sapiens]
          Length = 873

 Score =  256 bits (648), Expect = 1e-66
 Identities = 45/247 (18%), Positives = 82/247 (32%), Gaps = 34/247 (13%)

Query: 29  DSTGKAMSNQFSPPAVIDQVVFVMVDALRADFVFSKSHNMPFTQSLLYNSTHGIGFSAFA 88
                     F  P      +   +D  RA+++ +    +P    L    T+        
Sbjct: 145 SINEPQCPAGFETPP----TLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMR--P 198

Query: 89  RSPTVTMPRLKALTTGTIPGFLDVLLN-IAESDTGSSI-------------EAQDSWVYQ 134
             PT T P   ++ TG  P    ++ N + +    +S              + +  WV  
Sbjct: 199 VYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTA 258

Query: 135 LNSFNKKIEFYGDDTWLK---LFPSAFSKFEGTTSFFVSDYTEVDNNVTRNFDHALPSSL 191
                K   F+   + ++   +FP  +  + G        + E    V +     LP   
Sbjct: 259 KYQGLKSGTFFWPGSDVEINGIFPDIYKMYNG-----SVPFEERILAVLQWL--QLPKDE 311

Query: 192 SHSWDALILHYLGVDHIGHLYGPSSPLLNIKLLEIDTIISRIYKYLQEYDEKTNTHSLIV 251
                   L+    D  GH YGP S  +   L  +D ++  +   L+E +     +  ++
Sbjct: 312 RPH--FYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLN--LI 367

Query: 252 LCGDHGM 258
           L  DHGM
Sbjct: 368 LISDHGM 374
>emb|CAB99365.1| (AL117378) dJ131F15.2 (phosphodiesterase I/nucleotide
           pyrophosphatase 1 (homologous to mouse Ly-41 antigen)
           (PC1, NPPS)) [Homo sapiens]
          Length = 845

 Score =  254 bits (645), Expect = 3e-66
 Identities = 45/247 (18%), Positives = 82/247 (32%), Gaps = 34/247 (13%)

Query: 29  DSTGKAMSNQFSPPAVIDQVVFVMVDALRADFVFSKSHNMPFTQSLLYNSTHGIGFSAFA 88
                     F  P      +   +D  RA+++ +    +P    L    T+        
Sbjct: 117 SINEPQCPAGFETPP----TLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMR--P 170

Query: 89  RSPTVTMPRLKALTTGTIPGFLDVLLN-IAESDTGSSI-------------EAQDSWVYQ 134
             PT T P   ++ TG  P    ++ N + +    +S              + +  WV  
Sbjct: 171 VYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTA 230

Query: 135 LNSFNKKIEFYGDDTWLK---LFPSAFSKFEGTTSFFVSDYTEVDNNVTRNFDHALPSSL 191
                K   F+   + ++   +FP  +  + G        + E    V +     LP   
Sbjct: 231 KYQGLKSGTFFWPGSDVEINGIFPDIYKMYNG-----SVPFEERILAVLQWL--QLPKDE 283

Query: 192 SHSWDALILHYLGVDHIGHLYGPSSPLLNIKLLEIDTIISRIYKYLQEYDEKTNTHSLIV 251
                   L+    D  GH YGP S  +   L  +D ++  +   L+E +     +  ++
Sbjct: 284 RPH--FYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLN--LI 339

Query: 252 LCGDHGM 258
           L  DHGM
Sbjct: 340 LISDHGM 346
>gb|AAB61536.1| (U78788) alkaline phosphodiesterase [Rattus norvegicus]
          Length = 875

 Score =  253 bits (640), Expect = 1e-65
 Identities = 44/251 (17%), Positives = 84/251 (32%), Gaps = 34/251 (13%)

Query: 28  NDSTGKAMSNQFSPPAVIDQVVFVMVDALRADFVFSKSHNMPFTQSLLYNSTHGIGFSAF 87
             S        F  P     V+   +D  RA+++ + S  +P    L     H     A 
Sbjct: 146 ASSQEPQCPEGFDQPP----VILFSMDGFRAEYLQTWSTLLPNINKLKTCGLHSKYMRAM 201

Query: 88  ARSPTVTMPRLKALTTGTIPGFLDVLLN------------IAESDTGSSIEA--QDSWVY 133
              PT T P    + TG  P    ++ N            ++  +  +      Q  W+ 
Sbjct: 202 --YPTKTFPNHYTIVTGLYPESHGIIDNNMYDVYLNKNFSLSSVEKSNPAWWSGQPIWLT 259

Query: 134 QLNSFNKKIEFYGDDTWLKL---FPSAFSKFEGTTSFFVSDYTEVDNNVTRNFDHALPSS 190
            +    K   +Y   + + +   FP+ +  +          Y      + +  D  LP +
Sbjct: 260 AMYQGLKAASYYWPGSDVAVNGSFPNIYRNYS-----NSVPYESRIATLLQWLD--LPKA 312

Query: 191 LSHSWDALILHYLGVDHIGHLYGPSSPLLNIKLLEIDTIISRIYKYLQEYDEKTNTHSLI 250
                    ++    D  GH  GP S  +   L  +D     + + L++ +     +  I
Sbjct: 313 ER--PSFYTIYVEEPDSAGHKSGPVSAGVIKALQLVDDAFGMLMEGLKQRNLHNCVN--I 368

Query: 251 VLCGDHGMNEV 261
           ++  DHGM++ 
Sbjct: 369 IVLADHGMDQT 379
>dbj|BAA06333.1| (D30649) phosphodiesterase I [Rattus norvegicus]
          Length = 876

 Score =  252 bits (639), Expect = 1e-65
 Identities = 44/251 (17%), Positives = 84/251 (32%), Gaps = 34/251 (13%)

Query: 28  NDSTGKAMSNQFSPPAVIDQVVFVMVDALRADFVFSKSHNMPFTQSLLYNSTHGIGFSAF 87
             S        F  P     V+   +D  RA+++ + S  +P    L     H       
Sbjct: 146 ASSQEPQCPEGFDQPP----VILFSMDGFRAEYLQTWSTLLPNINKLKTCGLHSKYMR-- 199

Query: 88  ARSPTVTMPRLKALTTGTIPGFLDVLLN------------IAESDTGSSIEA--QDSWVY 133
           A  PT T P    + TG  P    ++ N            ++  +  +      Q  W+ 
Sbjct: 200 AVYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVYLNKNFSLSSVEKSNPAWWSGQPIWLT 259

Query: 134 QLNSFNKKIEFYGDDTWLKL---FPSAFSKFEGTTSFFVSDYTEVDNNVTRNFDHALPSS 190
            +    K   +Y   + + +   FP+ +  +          Y      + +  D  LP +
Sbjct: 260 AMYQGLKAASYYWPGSDVAVNGSFPNIYRNYS-----NSVPYESRIATLLQWLD--LPKA 312

Query: 191 LSHSWDALILHYLGVDHIGHLYGPSSPLLNIKLLEIDTIISRIYKYLQEYDEKTNTHSLI 250
                    ++    D  GH  GP S  +   L  +D     + + L++ +     +  I
Sbjct: 313 ER--PSFYTIYVEEPDSAGHKSGPVSAGVIKALQLVDDAFGMLMEGLKQRNLHNCVN--I 368

Query: 251 VLCGDHGMNEV 261
           ++  DHGM++ 
Sbjct: 369 IVLADHGMDQT 379
>ref|NP_445987.1| (NM_053535) ectonucleotide pyrophosphatase/phosphodiesterase 1
           [Rattus norvegicus]
 gb|AAK69654.1|AF340186_1 (AF340186) ecto-nucleotide pyrophosphatase/phosphodiesterase-1
           [Rattus norvegicus]
          Length = 906

 Score =  252 bits (639), Expect = 2e-65
 Identities = 43/247 (17%), Positives = 83/247 (33%), Gaps = 34/247 (13%)

Query: 29  DSTGKAMSNQFSPPAVIDQVVFVMVDALRADFVFSKSHNMPFTQSLLYNSTHGIGFSAFA 88
                    +F  P      +   +D  RA+++ +    +P    L    T+        
Sbjct: 179 TIDAPQCPAEFESPP----TLLFSLDGFRAEYLHTWGGLLPVISKLKNCGTYTKNMR--P 232

Query: 89  RSPTVTMPRLKALTTGTIPGFLDVLLN-IAESDTGSSI-------------EAQDSWVYQ 134
             PT T P   ++ TG  P    ++ N + +    +S              + Q  WV  
Sbjct: 233 VYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPLWYKGQPIWVTA 292

Query: 135 LNSFNKKIEFYGDDTWLK---LFPSAFSKFEGTTSFFVSDYTEVDNNVTRNFDHALPSSL 191
            +   +   ++   + ++   + P  +  + G        + E    V       LPS  
Sbjct: 293 NHQEVRSGTYFWPGSDVEIDGILPDIYKVYNG-----SVPFEERILAVLEWL--QLPSYE 345

Query: 192 SHSWDALILHYLGVDHIGHLYGPSSPLLNIKLLEIDTIISRIYKYLQEYDEKTNTHSLIV 251
                   L+    D  GH +GP S  +   L ++D I+  +   L++       +  ++
Sbjct: 346 RPH--FYTLYLEEPDSSGHSHGPVSSEVIKALQKVDHIVGMLMDGLKDLGLDKCLN--LI 401

Query: 252 LCGDHGM 258
           L  DHGM
Sbjct: 402 LISDHGM 408
>ref|NP_062243.1| (NM_019370) alkaline phosphodiesterase [Rattus norvegicus]
 gb|AAB61535.1| (U78787) alkaline phosphodiesterase [Rattus norvegicus]
          Length = 875

 Score =  252 bits (638), Expect = 2e-65
 Identities = 44/251 (17%), Positives = 84/251 (32%), Gaps = 34/251 (13%)

Query: 28  NDSTGKAMSNQFSPPAVIDQVVFVMVDALRADFVFSKSHNMPFTQSLLYNSTHGIGFSAF 87
             S        F  P     V+   +D  RA+++ + S  +P    L     H       
Sbjct: 146 ASSQEPQCPEGFDQPP----VILFSMDGFRAEYLQTWSTLLPNINKLKTCGLHSKYMR-- 199

Query: 88  ARSPTVTMPRLKALTTGTIPGFLDVLLN------------IAESDTGSSIEA--QDSWVY 133
           A  PT T P    + TG  P    ++ N            ++  +  +      Q  W+ 
Sbjct: 200 AVYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVYLNKNFSLSSVEKSNPAWWSGQPIWLT 259

Query: 134 QLNSFNKKIEFYGDDTWLKL---FPSAFSKFEGTTSFFVSDYTEVDNNVTRNFDHALPSS 190
            +    K   +Y   + + +   FP+ +  +          Y      + +  D  LP +
Sbjct: 260 AMYQGLKAASYYWPGSDVAVNGSFPNIYRNYS-----NSVPYESRIATLLQWLD--LPKA 312

Query: 191 LSHSWDALILHYLGVDHIGHLYGPSSPLLNIKLLEIDTIISRIYKYLQEYDEKTNTHSLI 250
                    ++    D  GH  GP S  +   L  +D     + + L++ +     +  I
Sbjct: 313 ER--PSFYTIYVEEPDSAGHKSGPVSAGVIKALQLVDDAFGMLMEGLKQRNLHNCVN--I 368

Query: 251 VLCGDHGMNEV 261
           ++  DHGM++ 
Sbjct: 369 IVLADHGMDQT 379
>gb|AAL26912.1| (AF320054) ecto-nucleotide pyrophosphatase [Rattus norvegicus]
          Length = 906

 Score =  252 bits (638), Expect = 2e-65
 Identities = 43/247 (17%), Positives = 83/247 (33%), Gaps = 34/247 (13%)

Query: 29  DSTGKAMSNQFSPPAVIDQVVFVMVDALRADFVFSKSHNMPFTQSLLYNSTHGIGFSAFA 88
                    +F  P      +   +D  RA+++ +    +P    L    T+        
Sbjct: 179 TIDAPQCPAEFESPP----TLLFSLDGFRAEYLHTWGGLLPVISKLKNCGTYTKNMR--P 232

Query: 89  RSPTVTMPRLKALTTGTIPGFLDVLLN-IAESDTGSSI-------------EAQDSWVYQ 134
             PT T P   ++ TG  P    ++ N + +    +S              + Q  WV  
Sbjct: 233 VYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPLWYKGQPIWVTA 292

Query: 135 LNSFNKKIEFYGDDTWLK---LFPSAFSKFEGTTSFFVSDYTEVDNNVTRNFDHALPSSL 191
            +   +   ++   + ++   + P  +  + G        + E    V       LPS  
Sbjct: 293 NHQEVRSGTYFWPGSDVEIDGILPDIYKVYNG-----SVPFEERILAVLEWL--QLPSYE 345

Query: 192 SHSWDALILHYLGVDHIGHLYGPSSPLLNIKLLEIDTIISRIYKYLQEYDEKTNTHSLIV 251
                   L+    D  GH +GP S  +   L ++D I+  +   L++       +  ++
Sbjct: 346 RPH--FYTLYLEEPDSSGHSHGPVSSEVIKALQKVDHIVGMLMDGLKDLGLDKCLN--LI 401

Query: 252 LCGDHGM 258
           L  DHGM
Sbjct: 402 LISDHGM 408
>gb|AAK69653.1|AF340185_1 (AF340185) ecto-nucleotide pyrophosphatase/phosphodiesterase-1
           [Rattus norvegicus]
          Length = 906

 Score =  252 bits (638), Expect = 2e-65
 Identities = 43/247 (17%), Positives = 83/247 (33%), Gaps = 34/247 (13%)

Query: 29  DSTGKAMSNQFSPPAVIDQVVFVMVDALRADFVFSKSHNMPFTQSLLYNSTHGIGFSAFA 88
                    +F  P      +   +D  RA+++ +    +P    L    T+        
Sbjct: 179 TIDAPQCPAEFESPP----TLLFSLDGFRAEYLHTWGGLLPVISKLKNCGTYTKNMR--P 232

Query: 89  RSPTVTMPRLKALTTGTIPGFLDVLLN-IAESDTGSSI-------------EAQDSWVYQ 134
             PT T P   ++ TG  P    ++ N + +    +S              + Q  WV  
Sbjct: 233 VYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPLWYKGQPIWVTA 292

Query: 135 LNSFNKKIEFYGDDTWLK---LFPSAFSKFEGTTSFFVSDYTEVDNNVTRNFDHALPSSL 191
            +   +   ++   + ++   + P  +  + G        + E    V       LPS  
Sbjct: 293 NHQEVRSGTYFWPGSDVEIDGILPDIYKVYNG-----SVPFEERILAVLEWL--QLPSYE 345

Query: 192 SHSWDALILHYLGVDHIGHLYGPSSPLLNIKLLEIDTIISRIYKYLQEYDEKTNTHSLIV 251
                   L+    D  GH +GP S  +   L ++D I+  +   L++       +  ++
Sbjct: 346 RPH--FYTLYLEEPDSSGHSHGPVSSEVIKALQKVDHIVGMLMDGLKDLGLDKCLN--LI 401

Query: 252 LCGDHGM 258
           L  DHGM
Sbjct: 402 LISDHGM 408
>pir||A57080 cell surface antigen RB13-6 - rat
 emb|CAA88029.1| (Z47987) RB13-6 antigen [Rattus norvegicus]
          Length = 875

 Score =  249 bits (630), Expect = 2e-64
 Identities = 44/251 (17%), Positives = 84/251 (32%), Gaps = 34/251 (13%)

Query: 28  NDSTGKAMSNQFSPPAVIDQVVFVMVDALRADFVFSKSHNMPFTQSLLYNSTHGIGFSAF 87
             S        F  P     V+   +D  RA+++ + S  +P    L     H     A 
Sbjct: 146 ASSQEPQCPEGFDQPP----VILFSMDGFRAEYLQTWSTLLPNINKLKTCGLHSKYMRAM 201

Query: 88  ARSPTVTMPRLKALTTGTIPGFLDVLLN------------IAESDTGSSIEA--QDSWVY 133
              PT T P    + TG  P    ++ N            ++  +  +      Q  W+ 
Sbjct: 202 --YPTKTFPNHYTIVTGLYPESHGIIDNNMYDVYLNKNFSLSSVEKSNPAWWSGQPIWLT 259

Query: 134 QLNSFNKKIEFYGDDTWLKL---FPSAFSKFEGTTSFFVSDYTEVDNNVTRNFDHALPSS 190
            +    K   +Y   + + +   FP+ +  +          Y      + +  D  LP +
Sbjct: 260 AMYQGLKAASYYWLGSDVAVNGSFPNIYRNYS-----NSVPYESRIATLLQWLD--LPKA 312

Query: 191 LSHSWDALILHYLGVDHIGHLYGPSSPLLNIKLLEIDTIISRIYKYLQEYDEKTNTHSLI 250
                    ++    D  GH  GP S  +   L  +D     + + L++ +     +  I
Sbjct: 313 ER--PSFYTIYVEEPDSAGHKSGPVSAGVIKALQLVDDAFGMLMEGLKQRNLHNCVN--I 368

Query: 251 VLCGDHGMNEV 261
           ++  DHGM++ 
Sbjct: 369 IVLADHGMDQT 379
>pir||T33724 hypothetical protein - Zymomonas mobilis
 gb|AAC70363.1| (AF086791) unknown [Zymomonas mobilis]
          Length = 429

 Score =  248 bits (629), Expect = 2e-64
 Identities = 60/285 (21%), Positives = 103/285 (36%), Gaps = 37/285 (12%)

Query: 48  VVFVMVDALRADFVFSKSHNMPFTQSLLYNSTHGIGFSAFARSPTVTMPRLKALTTGTIP 107
           ++ + +D  RAD++  K    P   SL  N ++          P++T P    L TG  P
Sbjct: 50  LILISIDGFRADYI--KRGLTPNLVSLAENGSYAKVM--HPSFPSITFPNHYTLVTGLYP 105

Query: 108 GFLDVLLNIAESDTGSSIEAQDSWVYQLNSF--NKKIEFYGDDTWLKLFPSAFSKFEGTT 165
               ++ N  +    + I     +    +    +++    G+  W+              
Sbjct: 106 DHHGIVGNNMDD---AHITPDSHFKMSDHQAATDRRWWDEGEPLWVTAEKQGVVSATMFW 162

Query: 166 SFFVSDYTEVDNNVTRNFDHALPSSLSHS-------------WDALILHYLGVDHIGHLY 212
               +D   V   + R FD  +P S                    + L++  VDH GHLY
Sbjct: 163 PGSEADIEGVRPEMWRQFDSHVPFSERVDQVFSWLAYPKKKRPQFITLYFENVDHAGHLY 222

Query: 213 GPSSPLLNIKLLEIDTIISRIYKYLQEYDEKTNTHSLIVLCGDHGMNEVGNHGGSSSGET 272
           GP S  +N  L++ID  I ++ + L++   K N    +V+  DHGM         SS   
Sbjct: 223 GPDSQEVNDNLVKIDQTIGQLVQGLKQRGIKAN----LVIVSDHGMAAT------SSDRV 272

Query: 273 TAALSLLFPSNELSHINKPILNMDDNPYSILERVEQVDVVPTICL 317
            A   +L PS            ++ +    L+     D+ P    
Sbjct: 273 VALNKILDPSLYHVVTGGAYAGIEPSSGHSLK-----DLEPLFAS 312
>ref|NP_032839.2| (NM_008813) phosphodiesterase I/nucleotide pyrophosphatase 1; 1
           ectonucleotide pyrophosphatase/phosphodiesterase 1 [Mus
           musculus]
 gb|AAA39893.2| (J02700) ecto-nucleotide pyrophosphatase/phosphodiesterase-1 [Mus
           musculus domesticus]
          Length = 905

 Score =  248 bits (629), Expect = 2e-64
 Identities = 43/247 (17%), Positives = 83/247 (33%), Gaps = 34/247 (13%)

Query: 29  DSTGKAMSNQFSPPAVIDQVVFVMVDALRADFVFSKSHNMPFTQSLLYNSTHGIGFSAFA 88
                    +F  P      +   +D  RA+++ +    +P    L    T+        
Sbjct: 179 SIDTPECPAEFESPP----TLLFSLDGFRAEYLHTWGGLLPVISKLKNCGTYTKNMRPM- 233

Query: 89  RSPTVTMPRLKALTTGTIPGFLDVLLN-IAESDTGSSI-------------EAQDSWVYQ 134
             PT T P   ++ TG  P    ++ N + +    +S              + Q  WV  
Sbjct: 234 -YPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPLWYKGQPIWVTA 292

Query: 135 LNSFNKKIEFYGDDTWLK---LFPSAFSKFEGTTSFFVSDYTEVDNNVTRNFDHALPSSL 191
            +   K   ++   + ++   + P  +  + G        + E    V       LPS  
Sbjct: 293 NHQEVKSGTYFWPGSDVEIDGILPDIYKVYNG-----SVPFEERILAVLEWL--QLPSHE 345

Query: 192 SHSWDALILHYLGVDHIGHLYGPSSPLLNIKLLEIDTIISRIYKYLQEYDEKTNTHSLIV 251
                   L+    D  GH +GP S  +   L ++D ++  +   L++       +  ++
Sbjct: 346 RPH--FYTLYLEEPDSSGHSHGPVSSEVIKALQKVDRLVGMLMDGLKDLGLDKCLN--LI 401

Query: 252 LCGDHGM 258
           L  DHGM
Sbjct: 402 LISDHGM 408
>gb|AAK84174.1|AF339910_1 (AF339910) ectonucleotide pyrophosphatase/phosphodiesterase 1
           allotype b [Mus musculus]
          Length = 906

 Score =  248 bits (629), Expect = 2e-64
 Identities = 43/247 (17%), Positives = 83/247 (33%), Gaps = 34/247 (13%)

Query: 29  DSTGKAMSNQFSPPAVIDQVVFVMVDALRADFVFSKSHNMPFTQSLLYNSTHGIGFSAFA 88
                    +F  P      +   +D  RA+++ +    +P    L    T+        
Sbjct: 179 SIDTPECPAEFESPP----TLLFSLDGFRAEYLHTWGGLLPVISKLKNCGTYTKNMRPM- 233

Query: 89  RSPTVTMPRLKALTTGTIPGFLDVLLN-IAESDTGSSI-------------EAQDSWVYQ 134
             PT T P   ++ TG  P    ++ N + +    +S              + Q  WV  
Sbjct: 234 -YPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPLWYKGQPIWVTA 292

Query: 135 LNSFNKKIEFYGDDTWLK---LFPSAFSKFEGTTSFFVSDYTEVDNNVTRNFDHALPSSL 191
            +   K   ++   + ++   + P  +  + G        + E    V       LPS  
Sbjct: 293 NHQEVKSGTYFWPGSDVEIDGILPDIYKVYNG-----SVPFEERILAVLEWL--QLPSHE 345

Query: 192 SHSWDALILHYLGVDHIGHLYGPSSPLLNIKLLEIDTIISRIYKYLQEYDEKTNTHSLIV 251
                   L+    D  GH +GP S  +   L ++D ++  +   L++       +  ++
Sbjct: 346 RPH--FYTLYLEEPDSSGHSHGPVSSEVIKALQKVDRLVGMLMDGLKDLGLDKCLN--LI 401

Query: 252 LCGDHGM 258
           L  DHGM
Sbjct: 402 LISDHGM 408
>pir||A27410 plasma cell membrane glycoprotein PC-1 - mouse
          Length = 905

 Score =  248 bits (629), Expect = 2e-64
 Identities = 43/247 (17%), Positives = 83/247 (33%), Gaps = 34/247 (13%)

Query: 29  DSTGKAMSNQFSPPAVIDQVVFVMVDALRADFVFSKSHNMPFTQSLLYNSTHGIGFSAFA 88
                    +F  P      +   +D  RA+++ +    +P    L    T+        
Sbjct: 179 SIDTPECPAEFESPP----TLLFSLDGFRAEYLHTWGGLLPVISKLKNCGTYTKNMRPM- 233

Query: 89  RSPTVTMPRLKALTTGTIPGFLDVLLN-IAESDTGSSI-------------EAQDSWVYQ 134
             PT T P   ++ TG  P    ++ N + +    +S              + Q  WV  
Sbjct: 234 -YPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPLWYKGQPIWVTA 292

Query: 135 LNSFNKKIEFYGDDTWLK---LFPSAFSKFEGTTSFFVSDYTEVDNNVTRNFDHALPSSL 191
            +   K   ++   + ++   + P  +  + G        + E    V       LPS  
Sbjct: 293 NHQEVKSGTYFWPGSDVEIDGILPDIYKVYNG-----SVPFEERILAVLEWL--QLPSHE 345

Query: 192 SHSWDALILHYLGVDHIGHLYGPSSPLLNIKLLEIDTIISRIYKYLQEYDEKTNTHSLIV 251
                   L+    D  GH +GP S  +   L ++D ++  +   L++       +  ++
Sbjct: 346 RPH--FYTLYLEEPDSSGHSHGPVSSEVIKALQKVDRLVGMLMDGLKDLGLDKCLN--LI 401

Query: 252 LCGDHGM 258
           L  DHGM
Sbjct: 402 LISDHGM 408
>sp|P06802|PC1_MOUSE Ectonucleotide pyrophosphatase/phosphodiesterase 1 (Plasma-cell
           membrane glycoprotein PC-1) [Includes: Alkaline
           phosphodiesterase I ; Nucleotide pyrophosphatase
           (NPPASE)]
          Length = 871

 Score =  247 bits (625), Expect = 6e-64
 Identities = 43/247 (17%), Positives = 83/247 (33%), Gaps = 34/247 (13%)

Query: 29  DSTGKAMSNQFSPPAVIDQVVFVMVDALRADFVFSKSHNMPFTQSLLYNSTHGIGFSAFA 88
                    +F  P      +   +D  RA+++ +    +P    L    T+        
Sbjct: 145 SIDTPECPAEFESPP----TLLFSLDGFRAEYLHTWGGLLPVISKLKNCGTYTKNMRPM- 199

Query: 89  RSPTVTMPRLKALTTGTIPGFLDVLLN-IAESDTGSSI-------------EAQDSWVYQ 134
             PT T P   ++ TG  P    ++ N + +    +S              + Q  WV  
Sbjct: 200 -YPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPLWYKGQPIWVTA 258

Query: 135 LNSFNKKIEFYGDDTWLK---LFPSAFSKFEGTTSFFVSDYTEVDNNVTRNFDHALPSSL 191
            +   K   ++   + ++   + P  +  + G        + E    V       LPS  
Sbjct: 259 NHQEVKSGTYFWPGSDVEIDGILPDIYKVYNG-----SVPFEERILAVLEWL--QLPSHE 311

Query: 192 SHSWDALILHYLGVDHIGHLYGPSSPLLNIKLLEIDTIISRIYKYLQEYDEKTNTHSLIV 251
                   L+    D  GH +GP S  +   L ++D ++  +   L++       +  ++
Sbjct: 312 RPH--FYTLYLEEPDSSGHSHGPVSSEVIKALQKVDRLVGMLMDGLKDLGLDKCLN--LI 367

Query: 252 LCGDHGM 258
           L  DHGM
Sbjct: 368 LISDHGM 374
>ref|XP_056208.1| (XM_056208) hypothetical protein MGC3079 [Homo sapiens]
 gb|AAH13987.1|AAH13987 (BC013987) Similar to hypothetical protein MGC3079 [Homo sapiens]
          Length = 454

 Score =  232 bits (587), Expect = 2e-59
 Identities = 70/215 (32%), Positives = 101/215 (46%), Gaps = 23/215 (10%)

Query: 190 SLSHSWDALILHYLGVDHIGHLYGPSSPLLNIKLLEIDTIISRIYKYLQEYDEKTNTHSL 249
             S  WD LI H+LGVDH GH +GP  P +  KL ++D +I  + + L+         +L
Sbjct: 1   MDSGEWDVLIAHFLGVDHCGHKHGPHHPEMAKKLSQMDQVIQGLVERLE-------NDTL 53

Query: 250 IVLCGDHGMNEVGNHGGSSSGETTAALSLLFPSNELSHINKPILNMDDNPYSILERVEQV 309
           +V+ GDHGM   G+HGG S  E +AAL L  P+                P    E + QV
Sbjct: 54  LVVAGDHGMTTNGDHGGDSELEVSAALFLYSPTAVFP----------STPPEEPEVIPQV 103

Query: 310 DVVPTICLLLGIPIPKGNMGKVLSPVTELWKDTKTAKMAALSNLFQLSLLKNPSLT-TSE 368
            +VPT+ LLLG+PIP GN+G+V++ +    +D+     +AL+    L L           
Sbjct: 104 SLVPTLALLLGLPIPFGNIGEVMAELFSGGEDS-QPHSSALAQASALHLNAQQVSRFLHT 162

Query: 369 LSTQFQDSDLNDIRLALENLQSQMVAQSSSYSLDR 403
            S   QD    +    L  LQ+     S+ Y    
Sbjct: 163 YSAATQDLQAKE----LHQLQNLFSKASADYQWLL 193
 Score = 75.8 bits (185), Expect = 2e-12
 Identities = 14/55 (25%), Positives = 26/55 (46%), Gaps = 1/55 (1%)

Query: 701 FWIMSSISLTFLCISCFIMRHHLFVWSVFSPKLLYNASWASMYFLAKCLISTIMV 755
           +  +  I +    ++  I+R HL VW VF+PK ++ A    +      L+   +V
Sbjct: 381 YLFILGIQILACALAASILRRHLMVWKVFAPKFIFEAVGFIVSS-VGLLLGIALV 434
 Score = 38.0 bits (88), Expect = 0.54
 Identities = 9/55 (16%), Positives = 20/55 (36%), Gaps = 3/55 (5%)

Query: 635 VAEQVAFFSLGNSNSLATVDLSQAYTGLDSYN---IFAVGILLFTSVFAGALWWC 686
           +     F+S G+      +    A+ G    +    +   +L+  + FA  L + 
Sbjct: 262 LMATQTFYSTGHQPVFPAIHWHAAFVGFPEGHGSCTWLPALLVGANTFASHLLFA 316
>pir||T03293 nucleotide pyrophosphatase homolog - rice
 gb|AAA67067.1| (U25430) nucleotide pyrophosphatase precursor [Oryza sativa]
 gb|AAF65458.1|AF245483_1 (AF245483) OSE4 [Oryza sativa]
 dbj|BAB56086.1| (AP003244) nucleotide pyrophosphatase homolog [Oryza sativa]
          Length = 479

 Score =  230 bits (583), Expect = 5e-59
 Identities = 51/273 (18%), Positives = 95/273 (34%), Gaps = 30/273 (10%)

Query: 8   IFWLQIFGSILFLLGFFPHKND----STGKAMSNQFSPPAVIDQVVFVMVDALRADFVFS 63
           +    +  +  +LL   P        +   A   Q      +  V+ +  D  R  +   
Sbjct: 50  LLTAALAVATSYLLLILPRTPLSAAPAPAAAARAQVKLEKPV--VILISSDGFRFGYQH- 106

Query: 64  KSHNMPFTQSLLYNSTHGIGFSAFARSPTVTMPRLKALTTGTIPGFLDVLLN-IAESDTG 122
                P    L+ N T           PT+T P   ++ TG  P    ++ N   +  +G
Sbjct: 107 -KAATPHIHRLIGNGTSAATGLVPI-FPTLTFPNHYSIATGLYPSSHGIINNYFPDPISG 164

Query: 123 SSI----------EAQDSWVYQLNSFNKKIEFYGDDTWLKLFPSAFSKFEGTTSFF--VS 170
                          +  WV   +   +   ++   + +K    ++   +     +    
Sbjct: 165 DYFTMSSHEPKWWLGEPLWVTAADQGIQAATYFWPGSEVK--KGSWDCPDKYCRHYNGSV 222

Query: 171 DYTEVDNNVTRNFDHALPSSLSHSWDALILHYLGVDHIGHLYGPSSPLLNIKLLEIDTII 230
            + E  + +   FD  LPS        L L++   DH GH  GP  P +   ++ ID +I
Sbjct: 223 PFEERVDAILGYFD--LPSDEMPQ--FLTLYFEDPDHQGHQVGPDDPAITEAVVRIDEMI 278

Query: 231 SRIYKYLQEYDEKTNTHSLIVLCGDHGMNEVGN 263
            R+   L+E     + +  ++L GDHGM    +
Sbjct: 279 GRLIAGLEERGVFEDVN--VILVGDHGMVGTCD 309
>ref|NP_194697.1| (NM_119113) nucleotide pyrophosphatase - like protein [Arabidopsis
           thaliana]
 pir||T09931 nucleotide pyrophosphatase homolog T16L4.190 - Arabidopsis thaliana
 emb|CAB45328.1| (AL079344) nucleotide pyrophosphatase-like protein [Arabidopsis
           thaliana]
 emb|CAB79726.1| (AL161575) nucleotide pyrophosphatase-like protein [Arabidopsis
           thaliana]
          Length = 496

 Score =  212 bits (535), Expect = 2e-53
 Identities = 49/282 (17%), Positives = 103/282 (36%), Gaps = 34/282 (12%)

Query: 5   FFGIFWLQIFGSILFLLGFFPHKN---DSTGKAMSNQFSPP--AVIDQV-----VFVMVD 54
              +  + +  +  F   FF  +         + S  F       + ++     + +  D
Sbjct: 56  LLLVTCIALSAASAFAFLFFSSQKPVLSLNQISKSPAFDRSVARPLKKLDKPVVLLISSD 115

Query: 55  ALRADFVFSKSHNMPFTQSLLYNSTHGIGFSAFARSPTVTMPRLKALTTGTIPGFLDVLL 114
             R  + F     +P    L+ N T           PT+T P   ++ TG  P +  ++ 
Sbjct: 116 GFRFGYQFKTK--LPSIHRLIANGTEAETGLIPV-FPTLTFPNHYSIVTGLYPAYHGIIN 172

Query: 115 N-IAESDTGSSI----------EAQDSWVYQLNSFNKKIEFYGDDTWLKLFPSAFSKFEG 163
           N   + +TG+              +  W   +N   K   ++   + +     +++  +G
Sbjct: 173 NHFVDPETGNVFTMASHEPEWWLGEPLWETVVNQGLKAATYFWPGSEV--HKGSWNCPQG 230

Query: 164 TTSFF--VSDYTEVDNNVTRNFDHALPSSLSHSWDALILHYLGVDHIGHLYGPSSPLLNI 221
               +     + +  + +   FD  LPS  +     + L++   DH GH  GP  P +  
Sbjct: 231 LCQNYNGSVPFDDRVDTILSYFD--LPS--NEIPSFMTLYFEDPDHQGHQVGPDDPQITE 286

Query: 222 KLLEIDTIISRIYKYLQEYDEKTNTHSLIVLCGDHGMNEVGN 263
            ++ ID +I R+   L++     +    +++ GDHGM    +
Sbjct: 287 AVVNIDRLIGRLIDGLEKRGIFEDV--TMIMVGDHGMVGTCD 326
CPU time:   222.01 user secs.	    2.96 sys. secs	  224.97 total secs.

  Database: nr
    Posted date:  Apr 21, 2002  2:19 PM
  Number of letters in database: 277,845,442
  Number of sequences in database:  887,402
  
Lambda     K      H
   0.317    0.180    0.490 

Gapped
Lambda     K      H
   0.270   0.0630    0.230 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 526317995
Number of Sequences: 887402
Number of extensions: 29026380
Number of successful extensions: 141783
Number of sequences better than 10.0: 953
Number of HSP's better than 10.0 without gapping: 124
Number of HSP's successfully gapped in prelim test: 842
Number of HSP's that attempted gapping in prelim test: 139825
Number of HSP's gapped (non-prelim): 1999
length of query: 758
length of database: 277,845,442
effective HSP length: 57
effective length of query: 701
effective length of database: 227,263,528
effective search space: 159311733128
effective search space used: 159311733128
T: 11
A: 40
X1: 15 ( 6.9 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 40 (20.8 bits)
S2: 77 (34.0 bits)