AA bar SignalP LCR TM
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Tumor Endothelial Marker Report: TEM4 (Dkk-3)

TEM domain structure

site-guide


TEM Sequence Analysis
name from to source/E description
SignalP 1 24 SignalP  
unknown 25 146   A coil is spanning from residue 39 to 85 (E-rich). At position 96, 106, 121 potential N-glycosylation sites can be found which are conserved between species. Homology to the N-terminal region of TEM4 can be found in soggy-1, another Dkk family member.
Cys-1 147 195 Dkk alignment(Krupnik, 1999) This is the first out of two cysteine-rich domains conserved among Dkk proteins. It contains 10 cysteine residues found in Dkks and shows homology to cysteine-rich regions in integrin.
linker 196 207   A potential N-glycosylation site at residue 204 in Dkk-3 is conserved between species. The linker between Cys-1 and Cys-2 varies in length among Dkks.
Cys-2 208 273 Dkk alignment(Krupnik, 1999) This is the second out of two cysteine-rich domains identified in Dkk proteins. It contains 10 cysteine residues perserved in the protein family and shows homology to Cys-rich regions in integrin.
Cys-2 shows high conservation among Dkks, implying a conserved function.
Cysteine-positioning is similar to the one found in colipases.
unknown 273 311    
LCR 307 350 predator, SEG LCR (A, L, E). An extended helix is localized in this region, that has been suggested to be involved in protein-protein interaction.
350        

Remarks



Sequence Information
TEM TEM4
Reliability of Gen2Tag mapping
Cid->tag (Hs.4909) frequency:
tem4: CATG-CTTTCTTTGA=17/33 (EST oriented)
tem4: CATG-CTTTCTTTGA=45/72 (EST unoriented)
tem4: CATG-CTTTCTTTGA=6/8 (cDNA)

REMARKS: Unigen suggests a second cluster fitting the sequence tag: Hs.278503 regulated in glioma: A BlastN search against nr with the clustered Ests in Hs.278503 that are proposed to carry the tag was performed. The results show that the 3UTR of DKK and RIG cDNA show an overlap. The RIG cDNA contains the tag in an invers direction, thus is not correctly associated with the tag.
Analysis
  • BlastP against nr

  • Output Created by a Suite of Single Sequence Analysis Techniques
  • Protein Description
    SEQ.SOURCE: gi|6049608|gb|AAF02676.1|AF177396_1 dickkopf-3 [Homo sapiens]
    Protein Sequence
    MQRLGATLLCLLLAAAVPTAPAPAPTATSAPVKPGPALSYPQEEATLNEMFREVEELMEDTQHKLRSAVE
    EMEAEEAAAKASSEVNLANLPPSYHNETNTDTKVGNNTIHVHREIHKITNNQTGQMVFSETVITSVGDEE
    GRRSHECIIDEDCGPSMYCQFASFQYTCQPCRGQRMLCTRDSECCGDQLCVWGHCTKMATRGSNGTICDN
    QRDCQPGLCCAFQRGLLFPVCTPLPVEGELCHDPASRLLDLITWELEPDGALDRCPCASGLLCQPHSHSL
    VYVCKPTFVGSRDQDGEILLPREVPDEYEVGSFMEEVRQELEDLERSLTEEMALGEPAAAAAALLGGEEI
    SAGE-Tag CATG-CTTTCTTTGAG
    EST/cluster Description
    UNIGEN CLUSTER: UniGene Cluster Hs.4909 DKK3
    SEQ.SOURCE:gi|6049607|gb|AF177396.1|AF177396 Homo sapiens dickkopf-3 (DKK-3)
    MARKINGS: tem4 Tag in red
    EST/cluster Sequence
    GGCACGAGGGGGCGGCGGCTGCGGGCGCAGAGCGGAGATGCAGCGGCTTGGGGCCACCCTGCTGTGCCTG
    CTGCTGGCGGCGGCGGTCCCCACGGCCCCCGCGCCCGCTCCGACGGCGACCTCGGCTCCAGTCAAGCCCG
    GCCCGGCTCTCAGCTACCCGCAGGAGGAGGCCACCCTCAATGAGATGTTCCGCGAGGTTGAGGAACTGAT
    GGAGGACACGCAGCACAAATTGCGCAGCGCGGTGGAAGAGATGGAGGCAGAAGAAGCTGCTGCTAAAGCA
    TCATCAGAAGTGAACCTGGCAAACTTACCTCCCAGCTATCACAATGAGACCAACACAGACACGAAGGTTG
    GAAATAATACCATCCATGTGCACCGAGAAATTCACAAGATAACCAACAACCAGACTGGACAAATGGTCTT
    TTCAGAGACAGTTATCACATCTGTGGGAGACGAAGAAGGCAGAAGGAGCCACGAGTGCATCATCGACGAG
    GACTGTGGGCCCAGCATGTACTGCCAGTTTGCCAGCTTCCAGTACACCTGCCAGCCATGCCGGGGCCAGA
    GGATGCTCTGCACCCGGGACAGTGAGTGCTGTGGAGACCAGCTGTGTGTCTGGGGTCACTGCACCAAAAT
    GGCCACCAGGGGCAGCAATGGGACCATCTGTGACAACCAGAGGGACTGCCAGCCGGGGCTGTGCTGTGCC
    TTCCAGAGAGGCCTGCTGTTCCCTGTGTGCACACCCCTGCCCGTGGAGGGCGAGCTTTGCCATGACCCCG
    CCAGCCGGCTTCTGGACCTCATCACCTGGGAGCTAGAGCCTGATGGAGCCTTGGACCGATGCCCTTGTGC
    CAGTGGCCTCCTCTGCCAGCCCCACAGCCACAGCCTGGTGTATGTGTGCAAGCCGACCTTCGTGGGGAGC
    CGTGACCAAGATGGGGAGATCCTGCTGCCCAGAGAGGTCCCCGATGAGTATGAAGTTGGCAGCTTCATGG
    AGGAGGTGCGCCAGGAGCTGGAGGACCTGGAGAGGAGCCTGACTGAAGAGATGGCGCTGGGGGAGCCTGC
    GGCTGCCGCCGCTGCACTGCTGGGAGGGGAAGAGATTTAGATCTGGACCAGGCTGTGGGTAGATGTGCAA
    TAGAAATAGCTAATTTATTTCCCCANGTGTGTGCTTTAAGCGTGGGCTGACCAGGCTTCTTCCTACATCT
    TCTTCCCAGTAAGTTTCCCCTCTGGCTTGACAGCATGAGGTGTTGTGCATTTGTTCAGCTCCCCCAGGCT
    GTTCTCCAGGCTTCACAGTCTGGTGCTTGGGAGAGTCAGGCAGGGTTAAACTGCAGGAGCAGTTTGCCAC
    CCCTGTCCAGATTATTGGCTGCTTTGCCTCTACCAGTTGGCAGACAGCCGTTTGTTCTACATGGCTTTGA
    TAATTGTTTGAGGGGAGGAGATGGAAACAATGTGGAGTCTCCCTCTGATTGGTTTTGGGGAAATGTGGAG
    AAGAGTGCCCTGCTTTGCAAACATCAACCTGGCAAAAATGCAACAAATGAATTTTCCACGCAGTTCTTTC
    CATGGGCATAGGTAAGCTGTGCCTTCAGCTGTTGCAGATGAAATGTTCTGTTCACCCTGCATTACATGTG
    TTTATTCATCCAGCAGTGTTGCTCAGCTCCTACCTCTGTGCCAGGGCAGCATTTTCATATCCAAGATCAA
    TTCCCTCTCTCAGCACAGCCTGGGGAGGGGGTCATTGTTCTCCTCGTCCATCAGGGATTTCAGAGGCTCA
    GAGACTGCAAGCTGCTTGCCCAAGTCACACAGCTAGTGAAGACCAGAGCAGTTTCATCTGGTTGTGACTC
    TAAGCTCAGTGCTCTCTCCACTACCCCACACCAGCCTTGGTGCCACCAAAAGTGCTCCCCAAAAGGAAGG
    AGAATGGGATTTTTCTTTTGAGGCATGCACATCTGGAATTAAGGTCAAACTAATTCTCACATCCCTCTAA
    AAGTAAACTACTGTTAGGAACAGCAGTGTTCTCACAGTGTGGGGCAGCCGTCCTTCTAATGAAGACAATG
    ATATTGACACTGTCCCTCTTTGGCAGTTGCATTAGTAACTTTGAAAGGTATATGACTGAGCGTAGCATAC
    AGGTTAACCTGCAGAAACAGTACTTAGGTAATTGTAGGGCGAGGATTATAAATGAAATTTGCAAAATCAC
    TTAGCAGCAACTGAAGACAATTATCAACCACGTGGAGAAAATCAAACCGAGCAGGGCTGTGTGAAACATG
    GTTGTAATATGCGACTGCGAACACTGAACTCTACGCCACTCCACAAATGATGTTTTCAGGTGTCATGGAC
    TGTTGCCACCATGTATTCATCCAGAGTTCTTAAAGTTTAAAGTTGCACATGATTGTATAAGCATGCTTTC
    TTTGAGTTTTTAAATTATGTATAAACATAAGTTGCATTTAGAAATCAAGCATAAATCACTTCAACTGCTA
    AAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
    Genomic Sequence Description
    SEQ.SOURCE: upstream sequence: Ensemble: >AC025106.00003 invers complementary
    ANALYSIS: Promotoranalysis
    MARKINGS: transcribed sequences in bold
    Genomic Sequence
        1  CAAGCCTGAAGGCCAGATAAGACGGGCCTAGGATGCCGCGGAGACAGGGACAGTCAGTGA
        61  AGCAGATGTCTGCTTACGGTAGAGCTGGTAGCTGAGCCAGAACAGAAGGGCGGGGGGCGT
       121  GGGGCGTCAGGTGTCAGGCGCCCCGGCTGGACAATGACCGGGATGAGGCCCCTCTGCGGG
       181  GCGGGGTGGGCATGGTGGGCGGGCGGGGCTCGGGGCGGGGGCGGAGAGGGAGCCTGGTGG
       241  GCGGGCGGGGCGCGTCTTGCGGGCTCCCTCGGGTACCGGCGCTGCCGCACCCCGCCGCGC
       301  TCCCGCACCCGCGGCCCGCCCACCGCGCCGCTCCCGCATCTGCACCCGCAGCCCGGCGGC
       361  CTCCCGGCGGGAGCGAGCAGATCCAGTCCGGCCCGCAGCGCAACTCGGTCCAGTCGGGGT
       421  GGGTGAGGGGCGGCGGCGGGGGAGGGGACGACTCTGCTGAGCTCAGCCTCTCTTGGTGGA
       481  TGTGGGGCGGGGCGCTCGAGTAGGACCCGACGCCAAGGGGAGGGGGCTGACCTGTGCTTG
       541  GTCCACCCCAGGTAGGGGCTGAGAGAGGCTTGAGGTGGAAGTGGGGGTCGGGCACTCTGA
       601  CCTGGTCGAGGAGGGGCTAGGGTTTGAACCGGGGACAGAGTCTAGGTGAGCTGGGGCTTG
       661  GGAGCTATTAGCGTAGAGGATCCGGGTTCGGTTGCTCTGGCGAGGGCTCCAGCATCACAG
       721  GTGAGGAGCAGAGCTCAGCTTGTGCTCGAGGATGGGGGTGCGGGGTCCTGGGGCGATCGG
       781  GGCTCGGGCTGGAGCGGGTGGGGTCGCGTCTTTTCGGGTGTAGGGGAGCTGCGTTTTCAG
       841  GGGCCTCGGTTTCCTCCCGTCTCCGGGCGGGTGCGGGAAAGAGGGGCGCCAGGGGCGGGC
       901  GGCGGGGCGGAACGGGGCGGGGCGGCGGGCCCAGCGAGGGGGGTGGTCCGCGCGCCTCTG
       961  ATCGCGTTCCGGGACACACAGGCGGCGGCTGCGGGCGCAGAGCGGAGATGCAGCGGCTTG
      1021  GGGCCACCCTGCTGTGCCTGCTGCTGGCGGCGGCGGTCCCCACGGCCCCCGCGCCCGCTC
      1081  CGACGGCGACCTCGGCTCCAGTCAAGCCCGGCCCGGCTCTCAGCTACCCGCAGGAGGAGG
      1141  CCACCCTCAATGAGATGTTCCGCGAGGTTGAGGAACTGATGGAGGACACGCAGCACAAAT
      1201  TGCGCAGCGCGGTGGAAGAGGTGGGTGCGCCCTGGCGGCGCGGGGCTCTGAGAAGCGCCA
      1261  GACTGGGGGCAGCGAAGTCTGGGAAGGCATGGAAGAGCGCTGGCCAGGGACCTCGGGTCC
      1321  CGCGCAGGGCCTGGGAAGGGCCGACAGCAGATGCGGAGTGACCTGGAGGCAGCGCACGGT
      1381  GATCCCTACTCCCGCCTCGTTTTGCCTCCTTGCCAAAAAGTCTGGATCTGAGCCTGTCCA
      1441  CCGAGAGGCTCTGCACTGGACCCTCCCTAGGTAGCTGGGGCCACCACCTGCCTGCAGTTG
      1501  GCGTCAGGCATGCCGTTGGCCTTCCCTATTGTCAGCAGAGGTTTGCAGGGCCCCTGGTAT
      1561  TCCAGCACTGTGGTTTCACAGAAACCCGGGACAAGCTCCAGGCATCGCCAAGTTCTAGCT
      1621  TGTCCGTTATGCTTTGAGCTTGTTAGGATGCCATGCAGGGACAAAGAGGCAAAGAGCCCT
      1681  GAGCTTTGCTGGCAGTCTGTCTGGGCTGTCTTGCTTCTCACGCAATGTGGGGGCAGAGAG
      1741  GGAAGATGGAAATCCTAAATCTCAGCACTGTATGAGTGGCGGATGAGGATGTGAGAGGCA
      1801  ATACCCCCTCCACCCAACGGTGCTTCGCAGTTGTCCTGGGCTCAGGTCCTCCTCTGCCAC
      1861  TCAGTAGCAGGGTGACATTGGGCAAATCACTTAATATCCTGCACCTCAGTTTCCTGTGAA
      1921  AACTAAATGTCATATGTGTGGGCACCTGGCAAATAATAGGTGCGCAGTATTTAGCAACTA
      1981  TTATCAGATACCACGTACCTTAGCAAAGCTTTGCCTAGCTTCTGCCCTCCATCACCTCCA
      2041  GGTCTAAACACTGTGGGTGGCATCTTGTTCTGTCCTCTGTGATGGTCACCCACGCATGCC
      2101  CAGGGCTACCTGGGCAGGAGATGTCACTGGCCCAGCCCTCTCTGTCCAGGTGCGGGGAGC
      2161  TGTCCCTGGTGCCTGGGGTGGGTAGACGAGGGCGCTGTTGGGCCCAATCTGTCTGTAGCC
      2221  TGTGTCTATAGAGAGGAGCCAGCCGTCCTAGTGAAGGAGGCAGCAGGAAACCAATGTCCA
      2281  GGCTGGTTGGCCCCTGGTCTGGCTTCACATCCCTGCTGTCTCCAGCTTGGTATCCCCCTT
      2341  GGGCAAAGCCTTAACTGCTGGCCCTTGTCTCCAGGGGGAAGTTGCTTTCTCCCCGCAGCC
      2401  CTTTGTAGTTTGGGGCTATTTCCCTTCCCACTCCACAACAGTTAGCCTGTGGAGTTTGCA
      2461  GTGAAGGGGACACTGGCTTGGGAGGCAGTGAAATGGGCAGCTGTCCTTGAATATCCACTG
      2521  GACAGGCCCAGATCCCAAGACCCATGATCTTTCTGTTTCCTGTGATTGCAAAACAATCAT
      2581  GACATGGAGCAATTAAAGGGTGAAGGGATTCAGTTAGGCCCCAATGTCTCTTAACTCTGA
      2641  AGCTTCAAATTAAGTGGAGTTTGCGATGCCTCTGGTTCTAGGGCAGGCCATCTGCTTTCC
      2701  TTATCCAGGTTCTAGGACTTTCCCTCCTGCACACAGATTCCCGGTAAGACTGACTAAGTC
      2761  ACCTCTATGTTTTTGTGCCCACCACTGTTCAGAAAGTCTGCAGCGTGGTCCTCTGACGTT
      2821  AGCTTCTGCTGAGGGAGGAGAGAGAGCAGCAAGGGCCTCTTCAGTCTCTTCTTGAGCAGA
      2881  GCAGTGTGGGGCCCTGCAGGACCTAGTGACGGGGTCTTCTCCATGGGCGTTATCCAGACT
      2941  GGATTTTGCCAAGACCCCAGCTTTCCTCCCTCTAGATGTGGCTCTGTGTAGGTTGGGGGG
      3001  TTGAAGTTTGCCACCAGAGGAGATGTGGGCTGTCACTTCTACCCCACTCTTTCCCAGAGG
      3061  TGTCCTCGCTGGCAGTGGGTACAGGATGAGAGAGGTTGAACACCATGGCAGGAGAAGAGG
      3121  CAGTGGGGACTGATCTTCCCTCATCCAGTCCCTGCTCTGCCACTTACTGGCAGTGGCGTT
      3181  CCGAGTCTGAAGTGGAGAAATGTCCACGT


    Literature

    PubMed: 10570958 Functional and structural diversity of the human Dickkopf gene family.
    Krupnik VE, Sharp JD, Jiang C, Robison K, Chickering TW, Amaravadi L, Brown DE, Guyot D, Mays G, Leiby K, Chang B, Duong T, Goodearl AD, Gearing DP, Sokol SY, McCarthy SA
    Gene 1999 Oct 1;238(2):301-13
    PubMed: 10570245 Colipase: structure and interaction with pancreatic lipase.
    van Tilbeurgh H, Bezzine S, Cambillau C, Verger R, Carriere F
    Biochim Biophys Acta 1999 Nov 23;1441(2-3):173-84
    PubMed:1094049 Isolation and characterization of the 5-upstream and untranslated regions of the mouse type II iodothyronine deiodinase gene.
    Song S, Adachi K, Katsuyama M, Sorimachi K, Oka T.
    Mol Cell Endocrinol 2000 Jul 25;165(1-2):189-98


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