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TEM domain structure |
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TEM Sequence Analysis |
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name | from | to | source/E | description |
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SignalP | 1 | 24 | SignalP | |
unknown | 25 | 146 | A coil is spanning from residue 39 to 85 (E-rich). At position 96, 106, 121 potential N-glycosylation sites can be found which are conserved between species. Homology to the N-terminal region of TEM4 can be found in soggy-1, another Dkk family member. | |
Cys-1 | 147 | 195 | Dkk alignment(Krupnik, 1999) | This is the first out of two cysteine-rich domains conserved among Dkk proteins. It contains 10 cysteine residues found in Dkks and shows homology to cysteine-rich regions in integrin. |
linker | 196 | 207 | A potential N-glycosylation site at residue 204 in Dkk-3 is conserved between species. The linker between Cys-1 and Cys-2 varies in length among Dkks. | |
Cys-2 | 208 | 273 | Dkk alignment(Krupnik, 1999) | This is the second out of two cysteine-rich domains identified in Dkk proteins. It contains 10 cysteine residues perserved in the protein family and shows homology to Cys-rich regions in integrin. Cys-2 shows high conservation among Dkks, implying a conserved function. Cysteine-positioning is similar to the one found in colipases. |
unknown | 273 | 311 | ||
LCR | 307 | 350 | predator, SEG | LCR (A, L, E). An extended helix is localized in this region, that has been suggested to be involved in protein-protein interaction. |
350 |
Remarks |
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Sequence Information |
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TEM | TEM4 | ||||||
Reliability of Gen2Tag mapping |
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Analysis |
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Protein Description |
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Protein Sequence |
MQRLGATLLCLLLAAAVPTAPAPAPTATSAPVKPGPALSYPQEEATLNEMFREVEELMEDTQHKLRSAVE EMEAEEAAAKASSEVNLANLPPSYHNETNTDTKVGNNTIHVHREIHKITNNQTGQMVFSETVITSVGDEE GRRSHECIIDEDCGPSMYCQFASFQYTCQPCRGQRMLCTRDSECCGDQLCVWGHCTKMATRGSNGTICDN QRDCQPGLCCAFQRGLLFPVCTPLPVEGELCHDPASRLLDLITWELEPDGALDRCPCASGLLCQPHSHSL VYVCKPTFVGSRDQDGEILLPREVPDEYEVGSFMEEVRQELEDLERSLTEEMALGEPAAAAAALLGGEEI |
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SAGE-Tag | CATG-CTTTCTTTGAG | ||||||
EST/cluster Description |
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EST/cluster Sequence |
GGCACGAGGGGGCGGCGGCTGCGGGCGCAGAGCGGAGATGCAGCGGCTTGGGGCCACCCTGCTGTGCCTG CTGCTGGCGGCGGCGGTCCCCACGGCCCCCGCGCCCGCTCCGACGGCGACCTCGGCTCCAGTCAAGCCCG GCCCGGCTCTCAGCTACCCGCAGGAGGAGGCCACCCTCAATGAGATGTTCCGCGAGGTTGAGGAACTGAT GGAGGACACGCAGCACAAATTGCGCAGCGCGGTGGAAGAGATGGAGGCAGAAGAAGCTGCTGCTAAAGCA TCATCAGAAGTGAACCTGGCAAACTTACCTCCCAGCTATCACAATGAGACCAACACAGACACGAAGGTTG GAAATAATACCATCCATGTGCACCGAGAAATTCACAAGATAACCAACAACCAGACTGGACAAATGGTCTT TTCAGAGACAGTTATCACATCTGTGGGAGACGAAGAAGGCAGAAGGAGCCACGAGTGCATCATCGACGAG GACTGTGGGCCCAGCATGTACTGCCAGTTTGCCAGCTTCCAGTACACCTGCCAGCCATGCCGGGGCCAGA GGATGCTCTGCACCCGGGACAGTGAGTGCTGTGGAGACCAGCTGTGTGTCTGGGGTCACTGCACCAAAAT GGCCACCAGGGGCAGCAATGGGACCATCTGTGACAACCAGAGGGACTGCCAGCCGGGGCTGTGCTGTGCC TTCCAGAGAGGCCTGCTGTTCCCTGTGTGCACACCCCTGCCCGTGGAGGGCGAGCTTTGCCATGACCCCG CCAGCCGGCTTCTGGACCTCATCACCTGGGAGCTAGAGCCTGATGGAGCCTTGGACCGATGCCCTTGTGC CAGTGGCCTCCTCTGCCAGCCCCACAGCCACAGCCTGGTGTATGTGTGCAAGCCGACCTTCGTGGGGAGC CGTGACCAAGATGGGGAGATCCTGCTGCCCAGAGAGGTCCCCGATGAGTATGAAGTTGGCAGCTTCATGG AGGAGGTGCGCCAGGAGCTGGAGGACCTGGAGAGGAGCCTGACTGAAGAGATGGCGCTGGGGGAGCCTGC GGCTGCCGCCGCTGCACTGCTGGGAGGGGAAGAGATTTAGATCTGGACCAGGCTGTGGGTAGATGTGCAA TAGAAATAGCTAATTTATTTCCCCANGTGTGTGCTTTAAGCGTGGGCTGACCAGGCTTCTTCCTACATCT TCTTCCCAGTAAGTTTCCCCTCTGGCTTGACAGCATGAGGTGTTGTGCATTTGTTCAGCTCCCCCAGGCT GTTCTCCAGGCTTCACAGTCTGGTGCTTGGGAGAGTCAGGCAGGGTTAAACTGCAGGAGCAGTTTGCCAC CCCTGTCCAGATTATTGGCTGCTTTGCCTCTACCAGTTGGCAGACAGCCGTTTGTTCTACATGGCTTTGA TAATTGTTTGAGGGGAGGAGATGGAAACAATGTGGAGTCTCCCTCTGATTGGTTTTGGGGAAATGTGGAG AAGAGTGCCCTGCTTTGCAAACATCAACCTGGCAAAAATGCAACAAATGAATTTTCCACGCAGTTCTTTC CATGGGCATAGGTAAGCTGTGCCTTCAGCTGTTGCAGATGAAATGTTCTGTTCACCCTGCATTACATGTG TTTATTCATCCAGCAGTGTTGCTCAGCTCCTACCTCTGTGCCAGGGCAGCATTTTCATATCCAAGATCAA TTCCCTCTCTCAGCACAGCCTGGGGAGGGGGTCATTGTTCTCCTCGTCCATCAGGGATTTCAGAGGCTCA GAGACTGCAAGCTGCTTGCCCAAGTCACACAGCTAGTGAAGACCAGAGCAGTTTCATCTGGTTGTGACTC TAAGCTCAGTGCTCTCTCCACTACCCCACACCAGCCTTGGTGCCACCAAAAGTGCTCCCCAAAAGGAAGG AGAATGGGATTTTTCTTTTGAGGCATGCACATCTGGAATTAAGGTCAAACTAATTCTCACATCCCTCTAA AAGTAAACTACTGTTAGGAACAGCAGTGTTCTCACAGTGTGGGGCAGCCGTCCTTCTAATGAAGACAATG ATATTGACACTGTCCCTCTTTGGCAGTTGCATTAGTAACTTTGAAAGGTATATGACTGAGCGTAGCATAC AGGTTAACCTGCAGAAACAGTACTTAGGTAATTGTAGGGCGAGGATTATAAATGAAATTTGCAAAATCAC TTAGCAGCAACTGAAGACAATTATCAACCACGTGGAGAAAATCAAACCGAGCAGGGCTGTGTGAAACATG GTTGTAATATGCGACTGCGAACACTGAACTCTACGCCACTCCACAAATGATGTTTTCAGGTGTCATGGAC TGTTGCCACCATGTATTCATCCAGAGTTCTTAAAGTTTAAAGTTGCACATGATTGTATAAGCATGCTTTC TTTGAGTTTTTAAATTATGTATAAACATAAGTTGCATTTAGAAATCAAGCATAAATCACTTCAACTGCTA |
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Genomic Sequence Description |
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Genomic Sequence |
1 CAAGCCTGAAGGCCAGATAAGACGGGCCTAGGATGCCGCGGAGACAGGGACAGTCAGTGA 61 AGCAGATGTCTGCTTACGGTAGAGCTGGTAGCTGAGCCAGAACAGAAGGGCGGGGGGCGT 121 GGGGCGTCAGGTGTCAGGCGCCCCGGCTGGACAATGACCGGGATGAGGCCCCTCTGCGGG 181 GCGGGGTGGGCATGGTGGGCGGGCGGGGCTCGGGGCGGGGGCGGAGAGGGAGCCTGGTGG 241 GCGGGCGGGGCGCGTCTTGCGGGCTCCCTCGGGTACCGGCGCTGCCGCACCCCGCCGCGC 301 TCCCGCACCCGCGGCCCGCCCACCGCGCCGCTCCCGCATCTGCACCCGCAGCCCGGCGGC 361 CTCCCGGCGGGAGCGAGCAGATCCAGTCCGGCCCGCAGCGCAACTCGGTCCAGTCGGGGT 421 GGGTGAGGGGCGGCGGCGGGGGAGGGGACGACTCTGCTGAGCTCAGCCTCTCTTGGTGGA 481 TGTGGGGCGGGGCGCTCGAGTAGGACCCGACGCCAAGGGGAGGGGGCTGACCTGTGCTTG 541 GTCCACCCCAGGTAGGGGCTGAGAGAGGCTTGAGGTGGAAGTGGGGGTCGGGCACTCTGA 601 CCTGGTCGAGGAGGGGCTAGGGTTTGAACCGGGGACAGAGTCTAGGTGAGCTGGGGCTTG 661 GGAGCTATTAGCGTAGAGGATCCGGGTTCGGTTGCTCTGGCGAGGGCTCCAGCATCACAG 721 GTGAGGAGCAGAGCTCAGCTTGTGCTCGAGGATGGGGGTGCGGGGTCCTGGGGCGATCGG 781 GGCTCGGGCTGGAGCGGGTGGGGTCGCGTCTTTTCGGGTGTAGGGGAGCTGCGTTTTCAG 841 GGGCCTCGGTTTCCTCCCGTCTCCGGGCGGGTGCGGGAAAGAGGGGCGCCAGGGGCGGGC 901 GGCGGGGCGGAACGGGGCGGGGCGGCGGGCCCAGCGAGGGGGGTGGTCCGCGCGCCTCTG 961 ATCGCGTTCCGGGACACACAGGCGGCGGCTGCGGGCGCAGAGCGGAGATGCAGCGGCTTG 1021 GGGCCACCCTGCTGTGCCTGCTGCTGGCGGCGGCGGTCCCCACGGCCCCCGCGCCCGCTC 1081 CGACGGCGACCTCGGCTCCAGTCAAGCCCGGCCCGGCTCTCAGCTACCCGCAGGAGGAGG 1141 CCACCCTCAATGAGATGTTCCGCGAGGTTGAGGAACTGATGGAGGACACGCAGCACAAAT 1201 TGCGCAGCGCGGTGGAAGAGGTGGGTGCGCCCTGGCGGCGCGGGGCTCTGAGAAGCGCCA 1261 GACTGGGGGCAGCGAAGTCTGGGAAGGCATGGAAGAGCGCTGGCCAGGGACCTCGGGTCC 1321 CGCGCAGGGCCTGGGAAGGGCCGACAGCAGATGCGGAGTGACCTGGAGGCAGCGCACGGT 1381 GATCCCTACTCCCGCCTCGTTTTGCCTCCTTGCCAAAAAGTCTGGATCTGAGCCTGTCCA 1441 CCGAGAGGCTCTGCACTGGACCCTCCCTAGGTAGCTGGGGCCACCACCTGCCTGCAGTTG 1501 GCGTCAGGCATGCCGTTGGCCTTCCCTATTGTCAGCAGAGGTTTGCAGGGCCCCTGGTAT 1561 TCCAGCACTGTGGTTTCACAGAAACCCGGGACAAGCTCCAGGCATCGCCAAGTTCTAGCT 1621 TGTCCGTTATGCTTTGAGCTTGTTAGGATGCCATGCAGGGACAAAGAGGCAAAGAGCCCT 1681 GAGCTTTGCTGGCAGTCTGTCTGGGCTGTCTTGCTTCTCACGCAATGTGGGGGCAGAGAG 1741 GGAAGATGGAAATCCTAAATCTCAGCACTGTATGAGTGGCGGATGAGGATGTGAGAGGCA 1801 ATACCCCCTCCACCCAACGGTGCTTCGCAGTTGTCCTGGGCTCAGGTCCTCCTCTGCCAC 1861 TCAGTAGCAGGGTGACATTGGGCAAATCACTTAATATCCTGCACCTCAGTTTCCTGTGAA 1921 AACTAAATGTCATATGTGTGGGCACCTGGCAAATAATAGGTGCGCAGTATTTAGCAACTA 1981 TTATCAGATACCACGTACCTTAGCAAAGCTTTGCCTAGCTTCTGCCCTCCATCACCTCCA 2041 GGTCTAAACACTGTGGGTGGCATCTTGTTCTGTCCTCTGTGATGGTCACCCACGCATGCC 2101 CAGGGCTACCTGGGCAGGAGATGTCACTGGCCCAGCCCTCTCTGTCCAGGTGCGGGGAGC 2161 TGTCCCTGGTGCCTGGGGTGGGTAGACGAGGGCGCTGTTGGGCCCAATCTGTCTGTAGCC 2221 TGTGTCTATAGAGAGGAGCCAGCCGTCCTAGTGAAGGAGGCAGCAGGAAACCAATGTCCA 2281 GGCTGGTTGGCCCCTGGTCTGGCTTCACATCCCTGCTGTCTCCAGCTTGGTATCCCCCTT 2341 GGGCAAAGCCTTAACTGCTGGCCCTTGTCTCCAGGGGGAAGTTGCTTTCTCCCCGCAGCC 2401 CTTTGTAGTTTGGGGCTATTTCCCTTCCCACTCCACAACAGTTAGCCTGTGGAGTTTGCA 2461 GTGAAGGGGACACTGGCTTGGGAGGCAGTGAAATGGGCAGCTGTCCTTGAATATCCACTG 2521 GACAGGCCCAGATCCCAAGACCCATGATCTTTCTGTTTCCTGTGATTGCAAAACAATCAT 2581 GACATGGAGCAATTAAAGGGTGAAGGGATTCAGTTAGGCCCCAATGTCTCTTAACTCTGA 2641 AGCTTCAAATTAAGTGGAGTTTGCGATGCCTCTGGTTCTAGGGCAGGCCATCTGCTTTCC 2701 TTATCCAGGTTCTAGGACTTTCCCTCCTGCACACAGATTCCCGGTAAGACTGACTAAGTC 2761 ACCTCTATGTTTTTGTGCCCACCACTGTTCAGAAAGTCTGCAGCGTGGTCCTCTGACGTT 2821 AGCTTCTGCTGAGGGAGGAGAGAGAGCAGCAAGGGCCTCTTCAGTCTCTTCTTGAGCAGA 2881 GCAGTGTGGGGCCCTGCAGGACCTAGTGACGGGGTCTTCTCCATGGGCGTTATCCAGACT 2941 GGATTTTGCCAAGACCCCAGCTTTCCTCCCTCTAGATGTGGCTCTGTGTAGGTTGGGGGG 3001 TTGAAGTTTGCCACCAGAGGAGATGTGGGCTGTCACTTCTACCCCACTCTTTCCCAGAGG 3061 TGTCCTCGCTGGCAGTGGGTACAGGATGAGAGAGGTTGAACACCATGGCAGGAGAAGAGG 3121 CAGTGGGGACTGATCTTCCCTCATCCAGTCCCTGCTCTGCCACTTACTGGCAGTGGCGTT 3181 CCGAGTCTGAAGTGGAGAAATGTCCACGT |
Literature |
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PubMed: 10570958 | Functional and structural diversity of the human Dickkopf gene family. Krupnik VE, Sharp JD, Jiang C, Robison K, Chickering TW, Amaravadi L, Brown DE, Guyot D, Mays G, Leiby K, Chang B, Duong T, Goodearl AD, Gearing DP, Sokol SY, McCarthy SA Gene 1999 Oct 1;238(2):301-13 |
PubMed: 10570245 | Colipase: structure and interaction with pancreatic lipase. van Tilbeurgh H, Bezzine S, Cambillau C, Verger R, Carriere F Biochim Biophys Acta 1999 Nov 23;1441(2-3):173-84 |
PubMed:1094049 | Isolation and characterization of the 5-upstream and untranslated regions of the mouse type II iodothyronine deiodinase gene. Song S, Adachi K, Katsuyama M, Sorimachi K, Oka T. Mol Cell Endocrinol 2000 Jul 25;165(1-2):189-98 |
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