|In-depth Sequence-analysis Study of Proteins
Differentially Expressed in Tumor Endothelium versus Normal Endothelium
The SAGE expression data used in this study are derived from the homepage of the SAGEnet Angiogenesis project and are described here and in:
St Croix B, Rago C, Velculescu V, Traverso G, Romans KE, Montgomery E, Lal A, Riggins GJ, Lengauer C, Vogelstein B, Kinzler KW.
Science. 2000 Aug 18;289(5482):1197-202.
The TEM project @ IMP bioinformatics
Maria Novatchkova & Frank Eisenhaber
Relying on the data published by Croix et al, the goal of the present report is a detailed functional characterization of the published tumor endothelial markers (TEMs) from their sequences. As a result of our study a common model emerges, describing the functional relationship between gene expression and altered behavior of tumor-associated endothelium. The majority of the TEMs have a function in the context of extracellular matrix and cytoskeleton modifications, and are thus consistently clustering in migration associated processes.
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