The RING-IBR-RING (RBR)-type family of ubiquitin-ligases: Parkin

Annotations:	PARKIN, Ubiquitin E3 ligase PRKN, Parkinson's Disease Related family member, Parkinson juvenile disease protein 2
Domain Architecture:	N ---|-- UBQ --|-------|--------- RBR ---------|- C

Fasta-File of the Family-Members

Fasta-File of Family-Members with complete RBR motif - full lenght sequences

Alignments:	- MView - Clustal

Fasta-File of Family-Members with complete RBR motif - RBR region

Alignments:	- MView - Clustal
HMM Search:	- HMM file - HMM output file

	Literature

PubMed: 16714300	Biochemical analysis of Parkinson's disease-causing variants of Parkin, an E3 ubiquitin-protein ligase with monoubiquitylation capacity. Hum Mol Genet. 2006 May 19;[Epub ahead of print]
PubMed: 16672220	Identification of far up stream element binding protein-1 as an authentic parkin substrate. J Biol Chem. 2006 May 3; [Epub ahead of print]
PubMed: 16332688	Parkin ubiquitinates and promotes the degradation of RanBP2. J Biol Chem. 2006 Feb 10;281(6):3595-603. Epub 2005 Dec 6.
PubMed: 16352719	Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration. Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18676-81. Epub 2005 Dec 13.
PubMed: 15152079	Parkin and relatives: the RBR family of ubiquitin ligases. Physiol Genomics. 2004 May 19;17(3):253-63.