The RING-IBR-RING (RBR)-type family of ubiquitin-ligases: Ariadne



Annotations:
Ankyrins: Ankyrin repeat, ANKIB1 protein
Ariadne1: ARI-1, Ariadne-1 protein homolog, Ubiquitin-conjugating enzyme E2-binding protein 1, UbcH7-binding protein, UbcM4-interacting protein 77
Ariadne2: ARI-2, Ariadne-2 protein homolog, Triad1
PARC: p53-associated parkin-like cytoplasmic protein, UbcH7-associated protein 1
other: ARIADNE-like protein, ubiquitin-protein ligase/ zinc ion binding, putative U3 small nucleolar ribonucleoprotein complex-associated protein
Domain Architecture:
Ankyrins: N --|ANK|--|ANK|--------------------------|----- RBR ------|--------------------------|UIM|----------- C
Ariadne1/Ariadne2: N |neg. charged cluster|-----|----- RBR ------|------------ C
PARC: N -----ARM/HEAT--//|---APC10---|--ARM/HEAT--//|---CULLIN---|---//---|----- RBR ------|--------|neg. charged cluster| C
Ariadne/fungi: N ------------|----- RBR ------|------------ C
Ariadne/plantA,plantB: N |neg. charged cluster|-----|----- RBR ------|------------ C
Ariadne/plantC: N ----|----- RBR ------|--------------------|ZnF|- C
Ariadne/protozoa: N ------------|----- RBR ------|------------ C
Ariadne/worms: N |neg. charged cluster|-----|----- RBR ------|------------ C


Fasta-File of the Family-Members

Fasta-File of Family-Members with complete RBR motif - full lenght sequences

Ankyrins Alignments: - MView
- Clustal
Ari1 Alignments: - MView
- Clustal
Ari2 Alignments: - MView
- Clustal
PARC Alignments: - MView
- Clustal
Fungi Alignments: - MView
- Clustal
Plant A Alignments: - MView
- Clustal
Plant B Alignments: - MView
- Clustal
Plant C Alignments: - MView
- Clustal
Protozoa Alignments: - MView
- Clustal
Worms Alignments: - MView
- Clustal

Fasta-File of Family-Members with complete RBR motif - RBR region

Alignments: - MView
- Clustal
HMM Search: - HMM file
- HMM output file

Literature
PubMed: 12526791 Parc: a cytoplasmic anchor for p53.
Cell. 2003 Jan 10;112(1):29-40.
PubMed: 12529512 Identification and characterization of the ARIADNE gene family in Arabidopsis. A group of putative E3 ligases.
Plant Physiol. 2003 Jan;131(1):27-40.
PubMed: 10880484 Ariadne-1: a vital Drosophila gene is required in development and defines a new conserved family of ring-finger proteins.
Genetics. 2000 Jul;155(3):1231-44.


Author: Birgit.Eisenhaber@imp.univie.ac.at on internet.
Last modified: 14th June 2006