BLASTP 2.2.6 [Apr-09-2003]

RID: 1063615035-18977-629781.BLASTQ3

Query= NP_509376 gi|17567279|ref|NP_509376_1| CREB-binding
protein like (XI780) [Caenorhabditis elegans]
         (295 letters)


Database: All non-redundant GenBank CDS
translations+PDB+SwissProt+PIR+PRF 
           1,523,846 sequences; 490,609,399 total letters

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|17567279|ref|NP_509376.1|  CREB-binding protein like (XI7...   529   e-149
gi|17552710|ref|NP_499160.1|  CBP/p300 homolog (cbp-1) [Caen...    75   2e-12
gi|2133462|pir||S60123  hypothetical protein R10E11.1 - Caen...    75   2e-12
gi|17552708|ref|NP_499161.1|  CBP/p300 homolog (cbp-1) [Caen...    75   2e-12
gi|737920|prf||1923401A  protein CBP                               52   1e-05
gi|547239|gb|AAB31182.1|  p300=transcription coactivator {N-...    51   3e-05
gi|27881767|gb|AAH44677.1|  Similar to CREB binding protein ...    50   3e-05
gi|2996629|gb|AAC08447.1|  CBP [Homo sapiens]                      50   4e-05
gi|28486616|ref|XP_283295.1|  similar to E1A-associated prot...    50   4e-05
gi|631119|pir||S39162  transcription coactivator CREB-bindin...    50   4e-05
gi|4321116|gb|AAC51331.2|  CREB-binding protein [Homo sapiens]     50   4e-05
gi|4758056|ref|NP_004371.1|  CREB binding protein [Homo sapi...    50   4e-05
gi|19547885|gb|AAL87531.1|  CREB-binding protein [Mus muscul...    50   4e-05
gi|1345703|sp|P45481|CBP_MOUSE  CREB-binding protein >gi|481...    50   4e-05
gi|21307831|gb|AAL54859.1|  CREB-binding protein [Aplysia ca...    50   6e-05
gi|31204369|ref|XP_311133.1|  ENSANGP00000004748 [Anopheles ...    50   7e-05
gi|4557557|ref|NP_001420.1|  E1A binding protein p300; E1A-b...    49   9e-05
gi|31753089|gb|AAH53889.1|  Unknown (protein for IMAGE:61513...    49   9e-05
gi|27663074|ref|XP_235502.1|  similar to E1A-associated prot...    49   1e-04
gi|27666550|ref|XP_235770.1|  similar to E1A-associated prot...    49   1e-04
gi|7511830|pir||T13828  CREB-binding protein homolog - fruit...    47   3e-04
gi|24640865|ref|NP_524642.2|  nejire CG15319-PB [Drosophila ...    47   4e-04
gi|4139873|pdb|1KDX|A  Chain A, Kix Domain Of Mouse Cbp (Cre...    46   7e-04
gi|482238|pir||S41033  hypothetical protein K03H1.10 - Caeno...    45   0.001
gi|17554044|ref|NP_499201.1|  CREB-binding protein like fami...    45   0.001

Alignments

>gi|17567279|ref|NP_509376.1| CREB-binding protein like (XI780) [Caenorhabditis elegans]
 gi|7499689|pir||T16139 hypothetical protein F22F1.3 - Caenorhabditis elegans
 gi|1118044|gb|AAA83283.1| Hypothetical protein F22F1.3 [Caenorhabditis elegans]
          Length = 295

 Score =  529 bits (1362), Expect = e-149
 Identities = 277/295 (93%), Positives = 277/295 (93%)

Query: 1   MKEAPTIEAVQIQNTMXXXXXXXXXXXXXXXXXXRPLTGFLVFAILSCYNMVIPELPYDD 60
           MKEAPTIEAVQIQNTM                  RPLTGFLVFAILSCYNMVIPELPYDD
Sbjct: 1   MKEAPTIEAVQIQNTMLSLPCLLPILPLFFLHVFRPLTGFLVFAILSCYNMVIPELPYDD 60

Query: 61  DDLSTLERGLRQYMITKIVREAVPRPNSDAKNDARMIELKEYATFMEKKSFEKVQTKDEY 120
           DDLSTLERGLRQYMITKIVREAVPRPNSDAKNDARMIELKEYATFMEKKSFEKVQTKDEY
Sbjct: 61  DDLSTLERGLRQYMITKIVREAVPRPNSDAKNDARMIELKEYATFMEKKSFEKVQTKDEY 120

Query: 121 YAELARIILSMQKHLQSRPKGSYEDPYSNIPPSHELADFLGLSAQERDEFYLLHPHRLLK 180
           YAELARIILSMQKHLQSRPKGSYEDPYSNIPPSHELADFLGLSAQERDEFYLLHPHRLLK
Sbjct: 121 YAELARIILSMQKHLQSRPKGSYEDPYSNIPPSHELADFLGLSAQERDEFYLLHPHRLLK 180

Query: 181 PNAKSRITRRIRIHVIDKLGLMLFPAPDQNAYYDGRMDRIIRKLRNLEAEAFRECIDCDD 240
           PNAKSRITRRIRIHVIDKLGLMLFPAPDQNAYYDGRMDRIIRKLRNLEAEAFRECIDCDD
Sbjct: 181 PNAKSRITRRIRIHVIDKLGLMLFPAPDQNAYYDGRMDRIIRKLRNLEAEAFRECIDCDD 240

Query: 241 YYNLASIKAYKLHKTMKKNGEHYVDHEVKYPAIHIYTSANSFESFALAESGIVIE 295
           YYNLASIKAYKLHKTMKKNGEHYVDHEVKYPAIHIYTSANSFESFALAESGIVIE
Sbjct: 241 YYNLASIKAYKLHKTMKKNGEHYVDHEVKYPAIHIYTSANSFESFALAESGIVIE 295



>gi|17552710|ref|NP_499160.1| CBP/p300 homolog (cbp-1) [Caenorhabditis elegans]
 gi|20455476|sp|P34545|CBP1_CAEEL Protein cbp-1
 gi|25299632|pir||G88564 protein R10E11.1 [imported] - Caenorhabditis elegans
 gi|17645979|emb|CAD18875.1| C. elegans CBP-1 protein (corresponding sequence R10E11.1b)
           [Caenorhabditis elegans]
          Length = 2056

 Score = 74.7 bits (182), Expect = 2e-12
 Identities = 48/131 (36%), Positives = 67/131 (51%), Gaps = 13/131 (9%)

Query: 50  NMVIPELPYDDDDLSTLE------RGLRQYMITKIVREAVPRPNSDAKNDARMIELKEYA 103
           N  IP LP  D    T E      + LR +++ K+V+   P PN +A ND R+ +L  YA
Sbjct: 580 NGEIPNLPPPDMPDCTKEWHHQVTKDLRNHLVGKLVKAIFPEPNQEAMNDNRLKDLIAYA 639

Query: 104 TFMEKKSFEKVQTKDEYYAELARIILSMQKHLQSRPK------GSYEDPYSNIPPSHELA 157
             +EK+ FE    ++EYY  LA  I  +QK LQ +         +  D Y+ IPPS+ELA
Sbjct: 640 RKVEKEMFESANDREEYYHLLAEKIYKIQKELQEKKNSRLNQGAAAHDQYA-IPPSNELA 698

Query: 158 DFLGLSAQERD 168
             LG+     D
Sbjct: 699 QMLGVEGGRSD 709




 Score = 54.7 bits (130), Expect = 2e-06
 Identities = 28/76 (36%), Positives = 45/76 (59%), Gaps = 2/76 (2%)

Query: 186 RITRRIRIHVIDKLGLMLFPAPDQNAYYDGRMDRIIRKLRNLEAEAFRECIDCDDYYNLA 245
           ++T+ +R H++ KL   +FP P+Q A  D R+  +I   R +E E F    D ++YY+L 
Sbjct: 601 QVTKDLRNHLVGKLVKAIFPEPNQEAMNDNRLKDLIAYARKVEKEMFESANDREEYYHLL 660

Query: 246 SIKAYKLHKTM--KKN 259
           + K YK+ K +  KKN
Sbjct: 661 AEKIYKIQKELQEKKN 676



>gi|2133462|pir||S60123 hypothetical protein R10E11.1 - Caenorhabditis elegans
          Length = 2027

 Score = 74.7 bits (182), Expect = 2e-12
 Identities = 48/131 (36%), Positives = 67/131 (51%), Gaps = 13/131 (9%)

Query: 50  NMVIPELPYDDDDLSTLE------RGLRQYMITKIVREAVPRPNSDAKNDARMIELKEYA 103
           N  IP LP  D    T E      + LR +++ K+V+   P PN +A ND R+ +L  YA
Sbjct: 580 NGEIPNLPPPDMPDCTKEWHHQVTKDLRNHLVGKLVKAIFPEPNQEAMNDNRLKDLIAYA 639

Query: 104 TFMEKKSFEKVQTKDEYYAELARIILSMQKHLQSRPK------GSYEDPYSNIPPSHELA 157
             +EK+ FE    ++EYY  LA  I  +QK LQ +         +  D Y+ IPPS+ELA
Sbjct: 640 RKVEKEMFESANDREEYYHLLAEKIYKIQKELQEKKNSRLNQGAAAHDQYA-IPPSNELA 698

Query: 158 DFLGLSAQERD 168
             LG+     D
Sbjct: 699 QMLGVEGGRSD 709




 Score = 54.7 bits (130), Expect = 2e-06
 Identities = 28/76 (36%), Positives = 45/76 (59%), Gaps = 2/76 (2%)

Query: 186 RITRRIRIHVIDKLGLMLFPAPDQNAYYDGRMDRIIRKLRNLEAEAFRECIDCDDYYNLA 245
           ++T+ +R H++ KL   +FP P+Q A  D R+  +I   R +E E F    D ++YY+L 
Sbjct: 601 QVTKDLRNHLVGKLVKAIFPEPNQEAMNDNRLKDLIAYARKVEKEMFESANDREEYYHLL 660

Query: 246 SIKAYKLHKTM--KKN 259
           + K YK+ K +  KKN
Sbjct: 661 AEKIYKIQKELQEKKN 676



>gi|17552708|ref|NP_499161.1| CBP/p300 homolog (cbp-1) [Caenorhabditis elegans]
 gi|14530537|emb|CAA82353.2| C. elegans CBP-1 protein (corresponding sequence R10E11.1a)
           [Caenorhabditis elegans]
          Length = 2045

 Score = 74.7 bits (182), Expect = 2e-12
 Identities = 48/131 (36%), Positives = 67/131 (51%), Gaps = 13/131 (9%)

Query: 50  NMVIPELPYDDDDLSTLE------RGLRQYMITKIVREAVPRPNSDAKNDARMIELKEYA 103
           N  IP LP  D    T E      + LR +++ K+V+   P PN +A ND R+ +L  YA
Sbjct: 569 NGEIPNLPPPDMPDCTKEWHHQVTKDLRNHLVGKLVKAIFPEPNQEAMNDNRLKDLIAYA 628

Query: 104 TFMEKKSFEKVQTKDEYYAELARIILSMQKHLQSRPK------GSYEDPYSNIPPSHELA 157
             +EK+ FE    ++EYY  LA  I  +QK LQ +         +  D Y+ IPPS+ELA
Sbjct: 629 RKVEKEMFESANDREEYYHLLAEKIYKIQKELQEKKNSRLNQGAAAHDQYA-IPPSNELA 687

Query: 158 DFLGLSAQERD 168
             LG+     D
Sbjct: 688 QMLGVEGGRSD 698




 Score = 54.3 bits (129), Expect = 2e-06
 Identities = 28/76 (36%), Positives = 45/76 (59%), Gaps = 2/76 (2%)

Query: 186 RITRRIRIHVIDKLGLMLFPAPDQNAYYDGRMDRIIRKLRNLEAEAFRECIDCDDYYNLA 245
           ++T+ +R H++ KL   +FP P+Q A  D R+  +I   R +E E F    D ++YY+L 
Sbjct: 590 QVTKDLRNHLVGKLVKAIFPEPNQEAMNDNRLKDLIAYARKVEKEMFESANDREEYYHLL 649

Query: 246 SIKAYKLHKTM--KKN 259
           + K YK+ K +  KKN
Sbjct: 650 AEKIYKIQKELQEKKN 665



>gi|737920|prf||1923401A protein CBP
          Length = 2441

 Score = 52.0 bits (123), Expect = 1e-05
 Identities = 23/73 (31%), Positives = 43/73 (58%)

Query: 186 RITRRIRIHVIDKLGLMLFPAPDQNAYYDGRMDRIIRKLRNLEAEAFRECIDCDDYYNLA 245
           R+T+ +R H++ KL   +FP PD  A  D RM+ ++   + +E + +      D+YY+L 
Sbjct: 594 RVTQDLRSHLVHKLVQAIFPTPDPAALKDRRMENLVAYAKKVEGDMYESANSRDEYYHLL 653

Query: 246 SIKAYKLHKTMKK 258
           + K YK+ K +++
Sbjct: 654 AEKIYKIQKELEE 666




 Score = 50.1 bits (118), Expect = 4e-05
 Identities = 25/69 (36%), Positives = 38/69 (55%)

Query: 70  LRQYMITKIVREAVPRPNSDAKNDARMIELKEYATFMEKKSFEKVQTKDEYYAELARIIL 129
           LR +++ K+V+   P P+  A  D RM  L  YA  +E   +E   ++DEYY  LA  I 
Sbjct: 599 LRSHLVHKLVQAIFPTPDPAALKDRRMENLVAYAKKVEGDMYESANSRDEYYHLLAEKIY 658

Query: 130 SMQKHLQSR 138
            +QK L+ +
Sbjct: 659 KIQKELEEK 667



>gi|547239|gb|AAB31182.1| p300=transcription coactivator {N-terminal} [mice, Peptide Partial,
           688 aa]
          Length = 688

 Score = 50.8 bits (120), Expect = 3e-05
 Identities = 23/72 (31%), Positives = 42/72 (58%)

Query: 187 ITRRIRIHVIDKLGLMLFPAPDQNAYYDGRMDRIIRKLRNLEAEAFRECIDCDDYYNLAS 246
           IT+ +R H++ KL   +FP PD  A  D RM+ ++   R +E + +    +  +YY+L +
Sbjct: 576 ITQDLRNHLVHKLVQAIFPTPDPAALKDRRMENLVAYARKVEGDMYESANNRAEYYHLLA 635

Query: 247 IKAYKLHKTMKK 258
            K YK+ K +++
Sbjct: 636 EKIYKIQKELEE 647




 Score = 47.8 bits (112), Expect = 2e-04
 Identities = 24/73 (32%), Positives = 38/73 (52%)

Query: 66  LERGLRQYMITKIVREAVPRPNSDAKNDARMIELKEYATFMEKKSFEKVQTKDEYYAELA 125
           + + LR +++ K+V+   P P+  A  D RM  L  YA  +E   +E    + EYY  LA
Sbjct: 576 ITQDLRNHLVHKLVQAIFPTPDPAALKDRRMENLVAYARKVEGDMYESANNRAEYYHLLA 635

Query: 126 RIILSMQKHLQSR 138
             I  +QK L+ +
Sbjct: 636 EKIYKIQKELEEK 648



>gi|27881767|gb|AAH44677.1| Similar to CREB binding protein (Rubinstein-Taybi syndrome)
           [Xenopus laevis]
          Length = 1047

 Score = 50.4 bits (119), Expect = 3e-05
 Identities = 25/69 (36%), Positives = 38/69 (55%)

Query: 70  LRQYMITKIVREAVPRPNSDAKNDARMIELKEYATFMEKKSFEKVQTKDEYYAELARIIL 129
           LR +++ K+V+   P P+  A  D RM  L  YA  +E   +E   ++DEYY  LA  I 
Sbjct: 589 LRNHLVHKLVQAIFPTPDPAALKDRRMENLVAYARKVEGDMYESANSRDEYYHFLAEKIY 648

Query: 130 SMQKHLQSR 138
            +QK L+ +
Sbjct: 649 KIQKELEEK 657




 Score = 50.4 bits (119), Expect = 4e-05
 Identities = 22/72 (30%), Positives = 41/72 (56%)

Query: 187 ITRRIRIHVIDKLGLMLFPAPDQNAYYDGRMDRIIRKLRNLEAEAFRECIDCDDYYNLAS 246
           +T+ +R H++ KL   +FP PD  A  D RM+ ++   R +E + +      D+YY+  +
Sbjct: 585 VTQDLRNHLVHKLVQAIFPTPDPAALKDRRMENLVAYARKVEGDMYESANSRDEYYHFLA 644

Query: 247 IKAYKLHKTMKK 258
            K YK+ K +++
Sbjct: 645 EKIYKIQKELEE 656



>gi|2996629|gb|AAC08447.1| CBP [Homo sapiens]
          Length = 555

 Score = 50.4 bits (119), Expect = 4e-05
 Identities = 25/69 (36%), Positives = 38/69 (55%)

Query: 70  LRQYMITKIVREAVPRPNSDAKNDARMIELKEYATFMEKKSFEKVQTKDEYYAELARIIL 129
           LR +++ K+V+   P P+  A  D RM  L  YA  +E   +E   ++DEYY  LA  I 
Sbjct: 334 LRSHLVHKLVQAIFPTPDPAALKDRRMENLVAYAKKVEGDMYESANSRDEYYHLLAEKIY 393

Query: 130 SMQKHLQSR 138
            +QK L+ +
Sbjct: 394 KIQKELEEK 402




 Score = 50.4 bits (119), Expect = 4e-05
 Identities = 22/72 (30%), Positives = 42/72 (58%)

Query: 187 ITRRIRIHVIDKLGLMLFPAPDQNAYYDGRMDRIIRKLRNLEAEAFRECIDCDDYYNLAS 246
           +T+ +R H++ KL   +FP PD  A  D RM+ ++   + +E + +      D+YY+L +
Sbjct: 330 VTQDLRSHLVHKLVQAIFPTPDPAALKDRRMENLVAYAKKVEGDMYESANSRDEYYHLLA 389

Query: 247 IKAYKLHKTMKK 258
            K YK+ K +++
Sbjct: 390 EKIYKIQKELEE 401



>gi|28486616|ref|XP_283295.1| similar to E1A-associated protein p300 [Mus musculus]
 gi|29244384|ref|NP_808489.1| hypothetical protein A730011L11 [Mus musculus]
 gi|26335221|dbj|BAC31311.1| unnamed protein product [Mus musculus]
          Length = 714

 Score = 50.4 bits (119), Expect = 4e-05
 Identities = 23/72 (31%), Positives = 42/72 (58%)

Query: 187 ITRRIRIHVIDKLGLMLFPAPDQNAYYDGRMDRIIRKLRNLEAEAFRECIDCDDYYNLAS 246
           IT+ +R H++ KL   +FP PD  A  D RM+ ++   R +E + +    +  +YY+L +
Sbjct: 576 ITQDLRNHLVHKLVQAIFPTPDPAALKDRRMENLVAYARKVEGDMYESANNRAEYYHLLA 635

Query: 247 IKAYKLHKTMKK 258
            K YK+ K +++
Sbjct: 636 EKIYKIQKELEE 647




 Score = 47.4 bits (111), Expect = 3e-04
 Identities = 24/73 (32%), Positives = 38/73 (52%)

Query: 66  LERGLRQYMITKIVREAVPRPNSDAKNDARMIELKEYATFMEKKSFEKVQTKDEYYAELA 125
           + + LR +++ K+V+   P P+  A  D RM  L  YA  +E   +E    + EYY  LA
Sbjct: 576 ITQDLRNHLVHKLVQAIFPTPDPAALKDRRMENLVAYARKVEGDMYESANNRAEYYHLLA 635

Query: 126 RIILSMQKHLQSR 138
             I  +QK L+ +
Sbjct: 636 EKIYKIQKELEEK 648



>gi|631119|pir||S39162 transcription coactivator CREB-binding protein - human
          Length = 2440

 Score = 50.1 bits (118), Expect = 4e-05
 Identities = 25/69 (36%), Positives = 38/69 (55%)

Query: 70  LRQYMITKIVREAVPRPNSDAKNDARMIELKEYATFMEKKSFEKVQTKDEYYAELARIIL 129
           LR +++ K+V+   P P+  A  D RM  L  YA  +E   +E   ++DEYY  LA  I 
Sbjct: 600 LRSHLVHKLVQAIFPTPDPAALKDRRMENLVAYAKKVEGDMYESANSRDEYYHLLAEKIY 659

Query: 130 SMQKHLQSR 138
            +QK L+ +
Sbjct: 660 KIQKELEEK 668




 Score = 50.1 bits (118), Expect = 4e-05
 Identities = 22/72 (30%), Positives = 42/72 (58%)

Query: 187 ITRRIRIHVIDKLGLMLFPAPDQNAYYDGRMDRIIRKLRNLEAEAFRECIDCDDYYNLAS 246
           +T+ +R H++ KL   +FP PD  A  D RM+ ++   + +E + +      D+YY+L +
Sbjct: 596 VTQDLRSHLVHKLVQAIFPTPDPAALKDRRMENLVAYAKKVEGDMYESANSRDEYYHLLA 655

Query: 247 IKAYKLHKTMKK 258
            K YK+ K +++
Sbjct: 656 EKIYKIQKELEE 667



>gi|4321116|gb|AAC51331.2| CREB-binding protein [Homo sapiens]
          Length = 2442

 Score = 50.1 bits (118), Expect = 4e-05
 Identities = 25/69 (36%), Positives = 38/69 (55%)

Query: 70  LRQYMITKIVREAVPRPNSDAKNDARMIELKEYATFMEKKSFEKVQTKDEYYAELARIIL 129
           LR +++ K+V+   P P+  A  D RM  L  YA  +E   +E   ++DEYY  LA  I 
Sbjct: 600 LRSHLVHKLVQAIFPTPDPAALKDRRMENLVAYAKKVEGDMYESANSRDEYYHLLAEKIY 659

Query: 130 SMQKHLQSR 138
            +QK L+ +
Sbjct: 660 KIQKELEEK 668




 Score = 50.1 bits (118), Expect = 5e-05
 Identities = 22/72 (30%), Positives = 42/72 (58%)

Query: 187 ITRRIRIHVIDKLGLMLFPAPDQNAYYDGRMDRIIRKLRNLEAEAFRECIDCDDYYNLAS 246
           +T+ +R H++ KL   +FP PD  A  D RM+ ++   + +E + +      D+YY+L +
Sbjct: 596 VTQDLRSHLVHKLVQAIFPTPDPAALKDRRMENLVAYAKKVEGDMYESANSRDEYYHLLA 655

Query: 247 IKAYKLHKTMKK 258
            K YK+ K +++
Sbjct: 656 EKIYKIQKELEE 667



>gi|4758056|ref|NP_004371.1| CREB binding protein [Homo sapiens]
 gi|3023440|sp|Q92793|CBP_HUMAN CREB-binding protein
 gi|2443859|gb|AAC51770.1| CREB-binding protein
          Length = 2442

 Score = 50.1 bits (118), Expect = 4e-05
 Identities = 25/69 (36%), Positives = 38/69 (55%)

Query: 70  LRQYMITKIVREAVPRPNSDAKNDARMIELKEYATFMEKKSFEKVQTKDEYYAELARIIL 129
           LR +++ K+V+   P P+  A  D RM  L  YA  +E   +E   ++DEYY  LA  I 
Sbjct: 600 LRSHLVHKLVQAIFPTPDPAALKDRRMENLVAYAKKVEGDMYESANSRDEYYHLLAEKIY 659

Query: 130 SMQKHLQSR 138
            +QK L+ +
Sbjct: 660 KIQKELEEK 668




 Score = 50.1 bits (118), Expect = 5e-05
 Identities = 22/72 (30%), Positives = 42/72 (58%)

Query: 187 ITRRIRIHVIDKLGLMLFPAPDQNAYYDGRMDRIIRKLRNLEAEAFRECIDCDDYYNLAS 246
           +T+ +R H++ KL   +FP PD  A  D RM+ ++   + +E + +      D+YY+L +
Sbjct: 596 VTQDLRSHLVHKLVQAIFPTPDPAALKDRRMENLVAYAKKVEGDMYESANSRDEYYHLLA 655

Query: 247 IKAYKLHKTMKK 258
            K YK+ K +++
Sbjct: 656 EKIYKIQKELEE 667



>gi|19547885|gb|AAL87531.1| CREB-binding protein [Mus musculus]
 gi|19547887|gb|AAL87532.1| CREB-binding protein [Mus musculus]
          Length = 2429

 Score = 50.1 bits (118), Expect = 4e-05
 Identities = 25/69 (36%), Positives = 38/69 (55%)

Query: 70  LRQYMITKIVREAVPRPNSDAKNDARMIELKEYATFMEKKSFEKVQTKDEYYAELARIIL 129
           LR +++ K+V+   P P+  A  D RM  L  YA  +E   +E   ++DEYY  LA  I 
Sbjct: 593 LRSHLVHKLVQAIFPTPDPAALKDRRMENLVAYAKKVEGDMYESANSRDEYYHLLAEKIY 652

Query: 130 SMQKHLQSR 138
            +QK L+ +
Sbjct: 653 KIQKELEEK 661




 Score = 50.1 bits (118), Expect = 5e-05
 Identities = 22/72 (30%), Positives = 42/72 (58%)

Query: 187 ITRRIRIHVIDKLGLMLFPAPDQNAYYDGRMDRIIRKLRNLEAEAFRECIDCDDYYNLAS 246
           +T+ +R H++ KL   +FP PD  A  D RM+ ++   + +E + +      D+YY+L +
Sbjct: 589 VTQDLRSHLVHKLVQAIFPTPDPAALKDRRMENLVAYAKKVEGDMYESANSRDEYYHLLA 648

Query: 247 IKAYKLHKTMKK 258
            K YK+ K +++
Sbjct: 649 EKIYKIQKELEE 660



>gi|1345703|sp|P45481|CBP_MOUSE CREB-binding protein
 gi|481698|pir||S39161 CREB-binding protein - mouse
 gi|435855|gb|AAB28651.1| CREB-binding protein; CBP [Mus sp.]
          Length = 2441

 Score = 50.1 bits (118), Expect = 4e-05
 Identities = 25/69 (36%), Positives = 38/69 (55%)

Query: 70  LRQYMITKIVREAVPRPNSDAKNDARMIELKEYATFMEKKSFEKVQTKDEYYAELARIIL 129
           LR +++ K+V+   P P+  A  D RM  L  YA  +E   +E   ++DEYY  LA  I 
Sbjct: 599 LRSHLVHKLVQAIFPTPDPAALKDRRMENLVAYAKKVEGDMYESANSRDEYYHLLAEKIY 658

Query: 130 SMQKHLQSR 138
            +QK L+ +
Sbjct: 659 KIQKELEEK 667




 Score = 50.1 bits (118), Expect = 5e-05
 Identities = 22/72 (30%), Positives = 42/72 (58%)

Query: 187 ITRRIRIHVIDKLGLMLFPAPDQNAYYDGRMDRIIRKLRNLEAEAFRECIDCDDYYNLAS 246
           +T+ +R H++ KL   +FP PD  A  D RM+ ++   + +E + +      D+YY+L +
Sbjct: 595 VTQDLRSHLVHKLVQAIFPTPDPAALKDRRMENLVAYAKKVEGDMYESANSRDEYYHLLA 654

Query: 247 IKAYKLHKTMKK 258
            K YK+ K +++
Sbjct: 655 EKIYKIQKELEE 666



>gi|21307831|gb|AAL54859.1| CREB-binding protein [Aplysia californica]
          Length = 2245

 Score = 49.7 bits (117), Expect = 6e-05
 Identities = 22/74 (29%), Positives = 42/74 (56%)

Query: 185 SRITRRIRIHVIDKLGLMLFPAPDQNAYYDGRMDRIIRKLRNLEAEAFRECIDCDDYYNL 244
           +++T+ +R H++ KL   +FP PDQ    D RM  ++   R +E + +    +   YY+L
Sbjct: 507 AQVTQDLRNHLVHKLVQAIFPTPDQATLRDSRMKNLVAYARKVEGDMYESANNRGQYYHL 566

Query: 245 ASIKAYKLHKTMKK 258
            + K YK+ K +++
Sbjct: 567 LAEKIYKIQKELEE 580




 Score = 44.7 bits (104), Expect = 0.002
 Identities = 22/69 (31%), Positives = 36/69 (52%)

Query: 70  LRQYMITKIVREAVPRPNSDAKNDARMIELKEYATFMEKKSFEKVQTKDEYYAELARIIL 129
           LR +++ K+V+   P P+     D+RM  L  YA  +E   +E    + +YY  LA  I 
Sbjct: 513 LRNHLVHKLVQAIFPTPDQATLRDSRMKNLVAYARKVEGDMYESANNRGQYYHLLAEKIY 572

Query: 130 SMQKHLQSR 138
            +QK L+ +
Sbjct: 573 KIQKELEEK 581



>gi|31204369|ref|XP_311133.1| ENSANGP00000004748 [Anopheles gambiae]
 gi|30178093|gb|EAA06516.2| ENSANGP00000004748 [Anopheles gambiae str. PEST]
          Length = 2572

 Score = 49.7 bits (117), Expect = 7e-05
 Identities = 24/69 (34%), Positives = 37/69 (53%)

Query: 70  LRQYMITKIVREAVPRPNSDAKNDARMIELKEYATFMEKKSFEKVQTKDEYYAELARIIL 129
           LR +++ K+V+   P P+  A  D RM  L  YA  +E   +E   ++ EYY  LA  I 
Sbjct: 753 LRNHLVHKLVQAIFPSPDPSAMFDKRMYNLVAYAKKVEGDMYEMANSRSEYYHLLAEKIY 812

Query: 130 SMQKHLQSR 138
            +QK L+ +
Sbjct: 813 KIQKELEEK 821




 Score = 48.1 bits (113), Expect = 2e-04
 Identities = 21/72 (29%), Positives = 42/72 (58%)

Query: 187 ITRRIRIHVIDKLGLMLFPAPDQNAYYDGRMDRIIRKLRNLEAEAFRECIDCDDYYNLAS 246
           +T  +R H++ KL   +FP+PD +A +D RM  ++   + +E + +       +YY+L +
Sbjct: 749 VTPDLRNHLVHKLVQAIFPSPDPSAMFDKRMYNLVAYAKKVEGDMYEMANSRSEYYHLLA 808

Query: 247 IKAYKLHKTMKK 258
            K YK+ K +++
Sbjct: 809 EKIYKIQKELEE 820



>gi|4557557|ref|NP_001420.1| E1A binding protein p300; E1A-binding protein, 300kD [Homo sapiens]
 gi|3024341|sp|Q09472|P300_HUMAN E1A-associated protein p300
 gi|627657|pir||A54277 transcription adaptor protein p300 - human
 gi|495301|gb|AAA18639.1| p300 protein
          Length = 2414

 Score = 49.3 bits (116), Expect = 9e-05
 Identities = 23/72 (31%), Positives = 42/72 (58%)

Query: 187 ITRRIRIHVIDKLGLMLFPAPDQNAYYDGRMDRIIRKLRNLEAEAFRECIDCDDYYNLAS 246
           IT+ +R H++ KL   +FP PD  A  D RM+ ++   R +E + +    +  +YY+L +
Sbjct: 575 ITQDLRNHLVHKLVQAIFPTPDPAALKDRRMENLVAYARKVEGDMYESANNRAEYYHLLA 634

Query: 247 IKAYKLHKTMKK 258
            K YK+ K +++
Sbjct: 635 EKIYKIQKELEE 646




 Score = 46.6 bits (109), Expect = 6e-04
 Identities = 24/73 (32%), Positives = 38/73 (52%)

Query: 66  LERGLRQYMITKIVREAVPRPNSDAKNDARMIELKEYATFMEKKSFEKVQTKDEYYAELA 125
           + + LR +++ K+V+   P P+  A  D RM  L  YA  +E   +E    + EYY  LA
Sbjct: 575 ITQDLRNHLVHKLVQAIFPTPDPAALKDRRMENLVAYARKVEGDMYESANNRAEYYHLLA 634

Query: 126 RIILSMQKHLQSR 138
             I  +QK L+ +
Sbjct: 635 EKIYKIQKELEEK 647



>gi|31753089|gb|AAH53889.1| Unknown (protein for IMAGE:6151364) [Homo sapiens]
          Length = 1553

 Score = 48.9 bits (115), Expect = 9e-05
 Identities = 23/72 (31%), Positives = 42/72 (58%)

Query: 187 ITRRIRIHVIDKLGLMLFPAPDQNAYYDGRMDRIIRKLRNLEAEAFRECIDCDDYYNLAS 246
           IT+ +R H++ KL   +FP PD  A  D RM+ ++   R +E + +    +  +YY+L +
Sbjct: 575 ITQDLRNHLVHKLVQAIFPTPDPAALKDRRMENLVAYARKVEGDMYESANNRAEYYHLLA 634

Query: 247 IKAYKLHKTMKK 258
            K YK+ K +++
Sbjct: 635 EKIYKIQKELEE 646




 Score = 46.2 bits (108), Expect = 6e-04
 Identities = 24/73 (32%), Positives = 38/73 (52%)

Query: 66  LERGLRQYMITKIVREAVPRPNSDAKNDARMIELKEYATFMEKKSFEKVQTKDEYYAELA 125
           + + LR +++ K+V+   P P+  A  D RM  L  YA  +E   +E    + EYY  LA
Sbjct: 575 ITQDLRNHLVHKLVQAIFPTPDPAALKDRRMENLVAYARKVEGDMYESANNRAEYYHLLA 634

Query: 126 RIILSMQKHLQSR 138
             I  +QK L+ +
Sbjct: 635 EKIYKIQKELEEK 647



>gi|27663074|ref|XP_235502.1| similar to E1A-associated protein p300 [Rattus norvegicus]
          Length = 2156

 Score = 48.9 bits (115), Expect = 1e-04
 Identities = 23/72 (31%), Positives = 42/72 (58%)

Query: 187 ITRRIRIHVIDKLGLMLFPAPDQNAYYDGRMDRIIRKLRNLEAEAFRECIDCDDYYNLAS 246
           IT+ +R H++ KL   +FP PD  A  D RM+ ++   R +E + +    +  +YY+L +
Sbjct: 204 ITQDLRNHLVHKLVQAIFPTPDPAALKDRRMENLVAYARKVEGDMYESANNRAEYYHLLA 263

Query: 247 IKAYKLHKTMKK 258
            K YK+ K +++
Sbjct: 264 EKIYKIQKELEE 275




 Score = 46.2 bits (108), Expect = 7e-04
 Identities = 24/73 (32%), Positives = 38/73 (52%)

Query: 66  LERGLRQYMITKIVREAVPRPNSDAKNDARMIELKEYATFMEKKSFEKVQTKDEYYAELA 125
           + + LR +++ K+V+   P P+  A  D RM  L  YA  +E   +E    + EYY  LA
Sbjct: 204 ITQDLRNHLVHKLVQAIFPTPDPAALKDRRMENLVAYARKVEGDMYESANNRAEYYHLLA 263

Query: 126 RIILSMQKHLQSR 138
             I  +QK L+ +
Sbjct: 264 EKIYKIQKELEEK 276



>gi|27666550|ref|XP_235770.1| similar to E1A-associated protein p300 [Rattus norvegicus]
          Length = 1605

 Score = 48.9 bits (115), Expect = 1e-04
 Identities = 23/72 (31%), Positives = 42/72 (58%)

Query: 187 ITRRIRIHVIDKLGLMLFPAPDQNAYYDGRMDRIIRKLRNLEAEAFRECIDCDDYYNLAS 246
           IT+ +R H++ KL   +FP PD  A  D RM+ ++   R +E + +    +  +YY+L +
Sbjct: 204 ITQDLRNHLVHKLVQAIFPTPDPAALKDRRMENLVAYARKVEGDMYESANNRAEYYHLLA 263

Query: 247 IKAYKLHKTMKK 258
            K YK+ K +++
Sbjct: 264 EKIYKIQKELEE 275




 Score = 46.2 bits (108), Expect = 7e-04
 Identities = 24/73 (32%), Positives = 38/73 (52%)

Query: 66  LERGLRQYMITKIVREAVPRPNSDAKNDARMIELKEYATFMEKKSFEKVQTKDEYYAELA 125
           + + LR +++ K+V+   P P+  A  D RM  L  YA  +E   +E    + EYY  LA
Sbjct: 204 ITQDLRNHLVHKLVQAIFPTPDPAALKDRRMENLVAYARKVEGDMYESANNRAEYYHLLA 263

Query: 126 RIILSMQKHLQSR 138
             I  +QK L+ +
Sbjct: 264 EKIYKIQKELEEK 276



>gi|7511830|pir||T13828 CREB-binding protein homolog - fruit fly (Drosophila melanogaster)
 gi|1916930|gb|AAB53050.1| CREB-binding protein homolog [Drosophila melanogaster]
          Length = 3190

 Score = 47.4 bits (111), Expect = 3e-04
 Identities = 23/69 (33%), Positives = 37/69 (53%)

Query: 70   LRQYMITKIVREAVPRPNSDAKNDARMIELKEYATFMEKKSFEKVQTKDEYYAELARIIL 129
            LR +++ K+V+   P  +     D RM  L  YA  +EK  +E  +++ EYY  LA  I 
Sbjct: 951  LRNHLVHKLVQAIFPTSDPTTMQDKRMHNLVSYAEKVEKDMYEMAKSRSEYYHLLAEKIY 1010

Query: 130  SMQKHLQSR 138
             +QK L+ +
Sbjct: 1011 KIQKELEEK 1019




 Score = 40.8 bits (94), Expect = 0.025
 Identities = 19/75 (25%), Positives = 37/75 (49%)

Query: 184  KSRITRRIRIHVIDKLGLMLFPAPDQNAYYDGRMDRIIRKLRNLEAEAFRECIDCDDYYN 243
            +  +T  +R H++ KL   +FP  D     D RM  ++     +E + +       +YY+
Sbjct: 944  RESVTADLRNHLVHKLVQAIFPTSDPTTMQDKRMHNLVSYAEKVEKDMYEMAKSRSEYYH 1003

Query: 244  LASIKAYKLHKTMKK 258
            L + K YK+ K +++
Sbjct: 1004 LLAEKIYKIQKELEE 1018



>gi|24640865|ref|NP_524642.2| nejire CG15319-PB [Drosophila melanogaster]
 gi|22833041|gb|AAF46516.2| CG15319-PB [Drosophila melanogaster]
          Length = 3276

 Score = 47.0 bits (110), Expect = 4e-04
 Identities = 23/69 (33%), Positives = 37/69 (53%)

Query: 70   LRQYMITKIVREAVPRPNSDAKNDARMIELKEYATFMEKKSFEKVQTKDEYYAELARIIL 129
            LR +++ K+V+   P  +     D RM  L  YA  +EK  +E  +++ EYY  LA  I 
Sbjct: 951  LRNHLVHKLVQAIFPTSDPTTMQDKRMHNLVSYAEKVEKDMYEMAKSRSEYYHLLAEKIY 1010

Query: 130  SMQKHLQSR 138
             +QK L+ +
Sbjct: 1011 KIQKELEEK 1019




 Score = 40.4 bits (93), Expect = 0.032
 Identities = 19/75 (25%), Positives = 37/75 (49%)

Query: 184  KSRITRRIRIHVIDKLGLMLFPAPDQNAYYDGRMDRIIRKLRNLEAEAFRECIDCDDYYN 243
            +  +T  +R H++ KL   +FP  D     D RM  ++     +E + +       +YY+
Sbjct: 944  RESVTADLRNHLVHKLVQAIFPTSDPTTMQDKRMHNLVSYAEKVEKDMYEMAKSRSEYYH 1003

Query: 244  LASIKAYKLHKTMKK 258
            L + K YK+ K +++
Sbjct: 1004 LLAEKIYKIQKELEE 1018



>gi|4139873|pdb|1KDX|A Chain A, Kix Domain Of Mouse Cbp (Creb Binding Protein) In Complex
           With Phosphorylated Kinase Inducible Domain (Pkid) Of
           Rat Creb (Cyclic Amp Response Element Binding Protein),
           Nmr 17 Structures
          Length = 81

 Score = 46.2 bits (108), Expect = 7e-04
 Identities = 22/72 (30%), Positives = 42/72 (58%)

Query: 187 ITRRIRIHVIDKLGLMLFPAPDQNAYYDGRMDRIIRKLRNLEAEAFRECIDCDDYYNLAS 246
           +T+ +R H++ KL   +FP PD  A  D RM+ ++   + +E + +      D+YY+L +
Sbjct: 10  VTQDLRSHLVHKLVQAIFPTPDPAALKDRRMENLVAYAKKVEGDMYESANSRDEYYHLLA 69

Query: 247 IKAYKLHKTMKK 258
            K YK+ K +++
Sbjct: 70  EKIYKIQKELEE 81




 Score = 45.4 bits (106), Expect = 0.001
 Identities = 25/67 (37%), Positives = 37/67 (55%)

Query: 70  LRQYMITKIVREAVPRPNSDAKNDARMIELKEYATFMEKKSFEKVQTKDEYYAELARIIL 129
           LR +++ K+V+   P P+  A  D RM  L  YA  +E   +E   ++DEYY  LA  I 
Sbjct: 14  LRSHLVHKLVQAIFPTPDPAALKDRRMENLVAYAKKVEGDMYESANSRDEYYHLLAEKIY 73

Query: 130 SMQKHLQ 136
            +QK L+
Sbjct: 74  KIQKELE 80



>gi|482238|pir||S41033 hypothetical protein K03H1.10 - Caenorhabditis elegans  (fragment)
          Length = 316

 Score = 45.1 bits (105), Expect = 0.001
 Identities = 25/69 (36%), Positives = 38/69 (55%), Gaps = 2/69 (2%)

Query: 70  LRQYMITKIVREAVPRPNSDAKNDARMIELKEYATFMEKKSFEKVQTKDEYYAELARIIL 129
           LR +++ K+V+   P P  +  ND R+ +L  YA  +EK+ FE    +  YY  LA  I 
Sbjct: 171 LRNHIVGKLVKAICPAP--EMMNDIRLKDLNAYARKVEKEVFETAIDRKNYYHLLAEKIY 228

Query: 130 SMQKHLQSR 138
            +QK LQ +
Sbjct: 229 EIQKELQEK 237




 Score = 39.3 bits (90), Expect = 0.071
 Identities = 22/73 (30%), Positives = 40/73 (54%), Gaps = 2/73 (2%)

Query: 186 RITRRIRIHVIDKLGLMLFPAPDQNAYYDGRMDRIIRKLRNLEAEAFRECIDCDDYYNLA 245
           ++T  +R H++ KL   + PAP+     D R+  +    R +E E F   ID  +YY+L 
Sbjct: 166 QVTNDLRNHIVGKLVKAICPAPEM--MNDIRLKDLNAYARKVEKEVFETAIDRKNYYHLL 223

Query: 246 SIKAYKLHKTMKK 258
           + K Y++ K +++
Sbjct: 224 AEKIYEIQKELQE 236



>gi|17554044|ref|NP_499201.1| CREB-binding protein like family member (36.7 kD) (3L15)
           [Caenorhabditis elegans]
 gi|25395947|pir||D88569 protein K03H1.10 [imported] - Caenorhabditis elegans
 gi|3877003|emb|CAA82940.1| Hypothetical protein K03H1.10 [Caenorhabditis elegans]
 gi|3878179|emb|CAA82665.1| Hypothetical protein K03H1.10 [Caenorhabditis elegans]
          Length = 322

 Score = 45.1 bits (105), Expect = 0.001
 Identities = 25/69 (36%), Positives = 38/69 (55%), Gaps = 2/69 (2%)

Query: 70  LRQYMITKIVREAVPRPNSDAKNDARMIELKEYATFMEKKSFEKVQTKDEYYAELARIIL 129
           LR +++ K+V+   P P  +  ND R+ +L  YA  +EK+ FE    +  YY  LA  I 
Sbjct: 177 LRNHIVGKLVKAICPAP--EMMNDIRLKDLNAYARKVEKEVFETAIDRKNYYHLLAEKIY 234

Query: 130 SMQKHLQSR 138
            +QK LQ +
Sbjct: 235 EIQKELQEK 243




 Score = 39.3 bits (90), Expect = 0.071
 Identities = 22/73 (30%), Positives = 40/73 (54%), Gaps = 2/73 (2%)

Query: 186 RITRRIRIHVIDKLGLMLFPAPDQNAYYDGRMDRIIRKLRNLEAEAFRECIDCDDYYNLA 245
           ++T  +R H++ KL   + PAP+     D R+  +    R +E E F   ID  +YY+L 
Sbjct: 172 QVTNDLRNHIVGKLVKAICPAPEM--MNDIRLKDLNAYARKVEKEVFETAIDRKNYYHLL 229

Query: 246 SIKAYKLHKTMKK 258
           + K Y++ K +++
Sbjct: 230 AEKIYEIQKELQE 242





  Database: All non-redundant GenBank CDS
  translations+PDB+SwissProt+PIR+PRF
    Posted date:  Sep 14, 2003  6:30 PM
  Number of letters in database: 490,609,399
  Number of sequences in database:  1,523,846
  
Lambda     K      H
   0.320    0.137    0.393 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,027,388
Number of Sequences: 1523846
Number of extensions: 519856
Number of successful extensions: 1212
Number of sequences better than  1.0: 0
Number of HSP's better than  1.0 without gapping: 0
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 1212
Number of HSP's gapped (non-prelim): 0
length of query: 295
length of database: 490,609,399
effective HSP length: 123
effective length of query: 172
effective length of database: 303,176,341
effective search space: 52146330652
effective search space used: 52146330652
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 81 (35.8 bits)