Query Fun_Sc_NP_014028.1_Dyn3p Command /cluster/toolkit/production/bioprogs/hhpred/hhsearch -cal -cpu 4 -v 1 -i /cluster/toolkit/production/tmp/production/96155/Sc_Dyn3.hhm -d /cluster/toolkit/production/databases/hhpred/new_dbs/pdb70_3Jan08/db/pdb.hhm /cluster/toolkit/production/databases/hhpred/new_dbs/scop70_1.72pre/db/scop.hhm /cluster/toolkit/production/databases/hhpred/new_dbs/scop70_1.71/db/scop.hhm /cluster/toolkit/production/databases/hhpred/new_dbs/pfamA_22.0/db/pfamA.hhm /cluster/toolkit/production/databases/hhpred/new_dbs/smart_18Apr07/db/smart.hhm /cluster/toolkit/production/databases/hhpred/new_dbs/pfam_18Apr07/db//pfam.hhm /cluster/toolkit/production/databases/hhpred/new_dbs/KOG_18Apr07/db/KOG.hhm /cluster/toolkit/production/databases/hhpred/new_dbs/COG_18Apr07/db/COG.hhm /cluster/toolkit/production/databases/hhpred/new_dbs/cd_18Apr07/db/cd.hhm /cluster/toolkit/production/databases/hhpred/new_dbs/panther_13Dec06/db/panther.hmm /cluster/toolkit/production/databases/hhpred/new_dbs/tigrfam_13Dec06/db/tigrfam.hmm /cluster/toolkit/production/databases/hhpred/new_dbs/pirsf_13Dec06/db/pirsf.hmm /cluster/toolkit/production/databases/hhpred/new_dbs/supfam_13Dec06/db/supfam.hmm /cluster/toolkit/production/databases/hhpred/new_dbs/CATH_13Dec06/db/CATH.hmm -o /cluster/toolkit/production/tmp/production/96155/Sc_Dyn3.hhr -p 20 -P 20 -Z 100 -B 100 -seq 1 -aliw 80 -local -ssm 2 -norealign -sc 1 No Hit Prob E-value P-value Score SS Cols Query HMM Template HMM 1 pfam05783 DLIC Dynein light in 100.0 0 0 667.0 17.1 276 2-301 24-365 (475) 2 KOG3905 Dynein light intermedi 100.0 0 0 634.0 18.7 276 2-301 29-370 (473) 3 PF05783 DLIC: Dynein light in 100.0 0 0 624.7 18.7 276 2-301 24-385 (525) 4 PTHR12688 DYNEIN LIGHT INTERME 100.0 0 0 471.8 7.0 222 58-301 1-282 (415) 5 PTHR13236 DYNEIN 2 LIGHT INTER 99.5 3E-12 3.1E-17 95.0 12.4 226 1-241 10-306 (397) 6 KOG3929 Uncharacterized conser 99.4 5E-13 5.3E-18 99.6 3.2 255 12-288 31-324 (363) 7 2q3h_A RAS homolog gene family 98.3 6.6E-05 6.8E-10 51.5 12.0 191 12-209 7-197 (201) 8 cd04101 RabL4 RabL4 (Rab-like4 98.0 0.0023 2.4E-08 42.4 15.4 159 28-208 3-164 (164) 9 1ek0_A GTP-binding protein YPT 97.9 0.0073 7.6E-08 39.4 16.5 166 24-211 2-168 (170) 10 2hxs_A RAB-26, RAS-related pro 97.9 0.0039 4E-08 41.0 14.5 176 20-217 1-178 (178) 11 cd04128 Spg1 Spg1p. Spg1p (se 97.9 0.0066 6.9E-08 39.6 15.3 170 28-218 3-173 (182) 12 cd00154 Rab Rab family. Rab G 97.8 0.0081 8.4E-08 39.1 15.0 151 28-201 3-155 (159) 13 1gwn_A RHO-related GTP-binding 97.8 0.0032 3.4E-08 41.5 12.7 190 8-206 12-203 (205) 14 cd00877 Ran Ran (Ras-related n 97.8 0.0041 4.3E-08 40.9 13.2 157 28-214 3-162 (166) 15 2atx_A Small GTP binding prote 97.8 0.0022 2.3E-08 42.4 11.7 185 15-206 8-192 (194) 16 2j1l_A RHO-related GTP-binding 97.8 0.002 2.1E-08 42.7 11.3 188 15-209 21-211 (214) 17 1z0f_A RAB14, member RAS oncog 97.7 0.018 1.9E-07 37.0 15.7 169 18-211 4-177 (179) 18 2oil_A CATX-8, RAS-related pro 97.7 0.013 1.3E-07 37.9 14.9 176 17-217 10-193 (193) 19 d1d5ca_ c.37.1.8 (A:) Rab6 {Ma 97.7 0.027 2.8E-07 36.0 15.9 152 28-201 4-156 (162) 20 2rex_B RHO-related GTP-binding 97.7 0.0025 2.6E-08 42.2 10.5 184 28-219 13-197 (197) 21 1x3s_A RAS-related protein RAB 97.6 0.016 1.6E-07 37.4 14.5 177 15-218 5-184 (195) 22 d3raba_ c.37.1.8 (A:) Rab3a {R 97.6 0.025 2.6E-07 36.2 15.2 159 28-213 8-169 (169) 23 e1z2aa_ c.37.1.8 (A:) Rab23 {M 97.6 0.0073 7.7E-08 39.4 12.4 153 27-202 4-157 (164) 24 d1oiva_ c.37.1.8 (A:) Rab11a { 97.6 0.025 2.7E-07 36.2 14.7 159 28-211 9-168 (168) 25 d1r2qa_ c.37.1.8 (A:) Rab5a {H 97.6 0.1 1.1E-06 32.6 17.7 168 20-212 1-169 (170) 26 cd04122 Rab14 Rab14 subfamily. 97.5 0.022 2.3E-07 36.5 13.7 157 28-211 5-164 (166) 27 e1x3sa1 c.37.1.8 (A:2-178) Rab 97.5 0.017 1.8E-07 37.2 13.1 170 19-215 1-173 (177) 28 cd01866 Rab2 Rab2 subfamily. 97.5 0.027 2.8E-07 36.0 14.1 158 28-213 7-168 (168) 29 2g6b_A RAS-related protein RAB 97.5 0.023 2.5E-07 36.4 13.7 166 28-218 13-180 (180) 30 d1ek0a_ c.37.1.8 (A:) Ypt51 {B 97.5 0.11 1.2E-06 32.3 17.1 165 24-210 2-167 (170) 31 cd04106 Rab23_lke Rab23-like s 97.5 0.03 3.1E-07 35.7 14.1 159 28-210 3-162 (162) 32 1oix_A RAS-related protein RAB 97.5 0.038 3.9E-07 35.1 14.6 159 28-211 32-191 (191) 33 d1r2qa_ c.37.1.8 (A:) Rab5a {H 97.5 0.14 1.5E-06 31.8 17.3 168 20-212 1-169 (170) 34 2p5s_A RAS and EF-hand domain 97.4 0.039 4E-07 35.1 14.2 166 28-213 31-198 (199) 35 2fg5_A RAB-22B, RAS-related pr 97.4 0.08 8.3E-07 33.2 15.8 164 28-216 26-190 (192) 36 e2atxa1 c.37.1.8 (A:9-193) Rho 97.4 0.027 2.9E-07 36.0 13.3 173 27-206 11-183 (185) 37 e1z0ja1 c.37.1.8 (A:2-168) Rab 97.4 0.038 4E-07 35.1 13.9 159 28-212 7-167 (167) 38 cd04110 Rab35 Rab35 subfamily. 97.4 0.038 4E-07 35.1 13.8 150 28-202 9-161 (199) 39 cd04113 Rab4 Rab4 subfamily. 97.4 0.074 7.7E-07 33.4 15.3 154 28-204 3-158 (161) 40 1m7b_A RND3/RHOE small GTP-bin 97.4 0.034 3.5E-07 35.4 13.3 178 20-206 2-182 (184) 41 d1byub_ c.37.1.8 (B:) Ran {Dog 97.4 0.0046 4.9E-08 40.5 8.8 166 28-221 12-178 (215) 42 1i2m_A RAN, GTP-binding nuclea 97.4 0.0079 8.3E-08 39.2 10.0 171 28-226 13-184 (216) 43 e2a5ja1 c.37.1.8 (A:9-181) Rab 97.4 0.033 3.5E-07 35.4 13.1 158 28-211 6-165 (173) 44 1z2a_A RAS-related protein RAB 97.3 0.026 2.7E-07 36.1 12.4 160 28-213 8-168 (168) 45 cd04124 RabL2 RabL2 subfamily. 97.3 0.042 4.4E-07 34.9 13.4 146 28-201 3-151 (161) 46 2fv8_A H6, RHO-related GTP-bin 97.3 0.017 1.8E-07 37.2 11.3 190 16-217 16-205 (207) 47 2gf9_A RAS-related protein RAB 97.3 0.057 5.9E-07 34.1 13.9 172 17-213 10-186 (189) 48 2nzj_A GTP-binding protein REM 97.3 0.085 8.9E-07 33.1 14.5 160 28-211 7-168 (175) 49 e1z06a1 c.37.1.8 (A:32-196) Ra 97.3 0.03 3.1E-07 35.7 12.2 154 28-201 5-162 (165) 50 d1wmsa_ c.37.1.8 (A:) Rab9a {H 97.3 0.13 1.4E-06 31.9 15.5 152 28-202 9-166 (174) 51 e1z0fa_ c.37.1.8 (A:) Rab14 {H 97.3 0.052 5.4E-07 34.3 13.3 159 28-211 8-167 (167) 52 e1yzqa1 c.37.1.8 (A:14-177) Ra 97.3 0.043 4.5E-07 34.8 12.9 160 28-212 3-163 (164) 53 2atv_A RERG, RAS-like estrogen 97.3 0.088 9.2E-07 33.0 14.4 168 24-217 27-196 (196) 54 cd01868 Rab11_like Rab11-like. 97.2 0.14 1.4E-06 31.8 15.1 158 28-211 6-165 (165) 55 cd00876 Ras Ras family. The R 97.2 0.097 1E-06 32.7 14.4 151 28-202 2-155 (160) 56 e2erxa1 c.37.1.8 (A:6-176) di- 97.2 0.091 9.5E-07 32.9 14.1 165 27-216 4-170 (171) 57 2erx_A GTP-binding protein DI- 97.2 0.11 1.1E-06 32.5 14.5 163 28-214 6-169 (172) 58 e2g6ba1 c.37.1.8 (A:58-227) Ra 97.2 0.035 3.6E-07 35.3 11.9 157 28-210 9-168 (170) 59 1r2q_A RAS-related protein RAB 97.2 0.4 4.1E-06 29.1 17.2 168 20-212 1-169 (170) 60 1yzq_A Small GTP binding prote 97.2 0.26 2.7E-06 30.2 16.3 168 20-212 1-169 (170) 61 1mh1 RAC1; GTP-binding, GTPa 97.2 0.027 2.8E-07 36.0 11.2 183 23-218 3-186 (186) 62 d1g16a_ c.37.1.8 (A:) Rab-rela 97.2 0.031 3.2E-07 35.7 11.4 160 27-213 4-165 (166) 63 cd04109 Rab28 Rab28 subfamily. 97.2 0.2 2.1E-06 30.9 15.5 194 28-244 3-198 (215) 64 cd01865 Rab3 Rab3 subfamily. 97.2 0.092 9.6E-07 32.9 13.8 158 28-213 4-165 (165) 65 e1xtqa1 c.37.1.8 (A:3-169) GTP 97.2 0.081 8.5E-07 33.2 13.5 164 22-209 1-167 (167) 66 1xtq_A GTP-binding protein RHE 97.2 0.26 2.7E-06 30.2 16.0 164 22-210 3-170 (177) 67 cd01861 Rab6 Rab6 subfamily. 97.2 0.13 1.3E-06 32.0 14.4 157 28-210 3-161 (161) 68 cd04132 Rho4_like Rho4-like su 97.2 0.16 1.6E-06 31.5 14.9 173 26-218 1-174 (187) 69 1z06_A RAS-related protein RAB 97.2 0.23 2.4E-06 30.5 15.6 161 28-210 23-186 (189) 70 d1m7ba_ c.37.1.8 (A:) RhoE (RN 97.2 0.055 5.8E-07 34.2 12.4 173 28-207 5-178 (179) 71 cd01860 Rab5_related Rab5-rela 97.1 0.17 1.8E-06 31.3 14.7 158 28-211 4-163 (163) 72 2ew1_A RAS-related protein RAB 97.1 0.27 2.8E-06 30.1 15.7 158 28-210 29-187 (201) 73 2a5j_A RAS-related protein RAB 97.1 0.12 1.3E-06 32.1 13.9 175 12-211 5-183 (191) 74 d1i2ma_ c.37.1.8 (A:) Ran {Hum 97.1 0.0096 1E-07 38.7 8.3 164 28-219 6-170 (170) 75 2g3y_A GTP-binding protein GEM 97.1 0.11 1.2E-06 32.4 13.7 192 4-218 16-209 (211) 76 2hup_A RAS-related protein RAB 97.1 0.37 3.9E-06 29.2 16.4 163 28-209 32-195 (201) 77 PF00071 Ras: Ras family; Int 97.1 0.24 2.5E-06 30.4 15.4 154 28-202 2-167 (174) 78 1x1r_A RAS-related protein M-R 97.1 0.13 1.3E-06 32.0 13.9 174 15-213 3-178 (178) 79 cd01864 Rab19 Rab19 subfamily. 97.1 0.19 1.9E-06 31.0 14.8 157 28-210 6-165 (165) 80 e2atva1 c.37.1.8 (A:5-172) Ras 97.1 0.22 2.3E-06 30.6 15.1 167 24-215 1-168 (168) 81 d1m7ba_ c.37.1.8 (A:) RhoE (RN 97.1 0.077 8E-07 33.3 12.8 171 28-207 5-178 (179) 82 cd00157 Rho Rho (Ras homology) 97.1 0.08 8.4E-07 33.2 12.9 163 28-200 3-165 (171) 83 2f9l_A RAB11B, member RAS onco 97.1 0.2 2E-06 30.9 14.9 177 28-226 8-186 (199) 84 cd04119 RJL RJL (RabJ-Like) su 97.1 0.16 1.7E-06 31.5 14.3 159 28-212 3-168 (168) 85 1z0j_A RAB-22, RAS-related pro 97.1 0.57 6E-06 28.1 17.1 153 28-202 9-162 (170) 86 cd04112 Rab26 Rab26 subfamily. 97.1 0.2 2.1E-06 30.9 14.6 167 28-220 3-172 (191) 87 1zd9_A ADP-ribosylation factor 97.1 0.082 8.5E-07 33.2 12.6 173 15-214 8-187 (188) 88 cd04123 Rab21 Rab21 subfamily. 97.1 0.22 2.3E-06 30.6 14.7 158 28-211 3-162 (162) 89 2fol_A RAS-related protein RAB 97.1 0.11 1.1E-06 32.4 13.1 172 17-213 10-189 (191) 90 2bov_A RAla, RAS-related prote 97.1 0.44 4.6E-06 28.8 16.3 153 28-202 17-170 (206) 91 pfam00071 Ras Ras family. Incl 97.0 0.2 2.1E-06 30.9 14.5 160 28-212 2-162 (162) 92 2j0v_A RAC-like GTP-binding pr 97.0 0.16 1.7E-06 31.4 13.9 172 28-219 12-187 (212) 93 1kao RAP2A; GTP-binding prot 97.0 0.49 5.1E-06 28.6 16.3 158 28-210 6-164 (167) 94 1zbd_A Rabphilin-3A; G protein 97.0 0.35 3.6E-06 29.4 15.4 159 28-211 11-170 (203) 95 d1kmqa_ c.37.1.8 (A:) RhoA {Hu 97.0 0.095 9.9E-07 32.8 12.4 173 26-208 3-176 (177) 96 cd01869 Rab1_Ypt1 Rab1/Ypt1 su 97.0 0.21 2.2E-06 30.8 14.0 160 28-213 5-166 (166) 97 cd01863 Rab18 Rab18 subfamily. 97.0 0.33 3.5E-06 29.6 15.0 156 28-210 3-161 (161) 98 2il1_A RAB12; G-protein, GDP, 97.0 0.38 4E-06 29.2 15.3 176 14-213 7-191 (192) 99 cd04117 Rab15 Rab15 subfamily. 97.0 0.63 6.6E-06 27.9 16.4 157 28-207 3-161 (161) 100 2f7s_A C25KG, RAS-related prot 96.9 0.25 2.6E-06 30.3 14.2 166 17-202 10-192 (217) No 1 >pfam05783 DLIC Dynein light intermediate chain (DLIC). This family consists of several eukaryotic dynein light intermediate chain proteins. The light intermediate chains (LICs) of cytoplasmic dynein consist of multiple isoforms, which undergo post-translational modification to produce a large number of species. DLIC1 is known to be involved in assembly, organisation, and function of centrosomes and mitotic spindles when bound to pericentrin. DLIC2 is a subunit of cytoplasmic dynein 2 that may play a role in maintaining Golgi organisation by binding cytoplasmic dynein 2 to its Golgi-associated cargo. Probab=100.00 E-value=0 Score=667.01 Aligned_columns=276 Identities=24% Q ss_pred CCCHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCE-EEEEEE Q ss_conf 8613889988641011465536644389975983317999998514778655665575025633562121332-688998 Q Fun_Sc_NP_0140 2 DNCNAWDKLLSQNESTINSTETATITAIIYSPSSKTLHQFINICFPEGSNSILDTTLINYATIGWTNDLKENY-SVDVYT 80 (312) Q Consensus 2 ~~~NlWs~iLse~~~~~~~k~~~~k~~lilg~~~~~~~~fi~~l~~~~~e~~~~~~~L~y~y~~v~~d~~d~~-R~~vy~ 80 (312) .++|||||||++|++++++|+|++||+||||+++.||++|+++| ||+++.++|+||||+|++|.|||+|++ ||+||+ T Consensus 24 ~k~nLWsSIL~~V~t~~r~Klp~~KniLVLG~~~~GKttLl~~L--qg~~~~kkg~aL~Y~YldV~DeD~Dd~~R~~vwi 101 (475) T pfam05783 24 EGQNLWSEILSEVSTRTRSKLPSGKNVLVLGDNGSGKTSLISRL--QGSERTKKGRGLEYLYLHVHDEDRDDLTRCNVWI 101 (475) T ss_pred HHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHH--HCCCCCCCCCCCCEEEECCCCCCHHHHCCCCEEE T ss_conf 12247898886530253334777664788508997557899975--0577667863101346323220303221542476 Q ss_pred EECCCHHHHHHHHHHHCCCC-CCCEEEEEECCCCCCHHHHHHHHHHHHHHHH---------------------------- Q ss_conf 60785435887887718778-7827999851666344689999999999864---------------------------- Q Fun_Sc_NP_0140 81 LIRNTDDALDLLKPFLQEHS-SKVRWLILLDWTLNDQKLWLNELSYAFNKIK---------------------------- 131 (312) Q Consensus 81 L~~~~~~~~~LLkp~L~~~s-~~~l~ViLLDWs~~Dp~~Wlr~Lr~~~~~L~---------------------------- 131 (312) |+++.+| .+||||+|++++ ++|++||+|||++ ||+|+++|+.|+..|+ T Consensus 102 Ld~~~~~-~~LLK~aL~~~si~~TlViI~lDms~--PW~~i~qL~~Wi~VLrehi~~L~i~~ee~~el~e~l~~~wqeY~ 178 (475) T pfam05783 102 LDGDLYH-KGLLKFALPATSLAETLVILTASMSN--PWTLLESLQKWASVLREHIDKLKIPPEEMKAGRQKLEKDWQEYV 178 (475) T ss_pred CCCCCCC-CCCCCCCCCCCCHHHHHEHHHHHHHH--HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH T ss_conf 0875152-22321257723142201200121201--34899999999999999997138998899999999999999860 Q ss_pred ---------------------------CCCCCC-------CEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH Q ss_conf ---------------------------068998-------7389984773456655324541157889999999999988 Q Fun_Sc_NP_0140 132 ---------------------------QLNDDN-------EFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYF 177 (312) Q Consensus 132 ---------------------------~l~~Dt-------~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~ 177 (312) .+++.+ +|+|||||||+|++|||+| +|+||||||||||||+|||+ T Consensus 179 epg~~~d~s~~r~t~~~~~~~~~~v~lPLgeg~Lt~NLGiPiiVVctKsD~ie~LEKe~-~ykeE~fDfIqq~LR~~cLq 257 (475) T pfam05783 179 EPGEDLDGSPQRRTSVVGSFDEEHVLLPLGQDTLTHNLGLPVLVVCTKCDAMSVLEKEH-DYRDEHFDFIQSHLRKFCLQ 257 (475) T ss_pred CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCEEEEEEEECCCHHHHHHCCC-CCCHHHHHHHHHHHHHHHHH T ss_conf 55346787763245665653444565778876341278826999861762133332015-66436799999999999987 Q ss_pred CCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCEEECCCCCHHHHHHHHCCCCCCCCCCCCCCC Q ss_conf 29415885256531355566778888753001247787752240115630206688814624200478874400643467 Q Fun_Sc_NP_0140 178 NDSSLFYICEDHTEEKREEAQRLKYQELLKHFCEDRDMKDHIEMVTRSEILIPKGCDSIGLIKTVDERFEPTEVKEQHFL 257 (312) Q Consensus 178 yGASLiYts~ts~~~~kn~~~~l~y~~L~~h~l~~~~~~~~a~vverd~vfIP~GwDS~~KI~ii~E~F~~~~V~~~d~~ 257 (312) |||||||| ++++.+|+.++|+| ++|++|||||+.+|.|+|||+||||+|||||+||+||||||+ +|+++| T Consensus 258 YGAsLiYT---S~ke~kNldlLykY---l~HrlYgfpf~~~a~VvekDaIfIPsGWDn~kKI~Il~Enf~--~~k~~~-- 327 (475) T pfam05783 258 YGAALIYT---SVKETKNIDLLYKY---IVHRSYGFPFTTPALVVEKDAVFIPAGWDNEKKIDILHENFP--TVKAED-- 327 (475) T ss_pred CCCEEEEE---CCCCCCCHHHHHHH---HHHHHHCCCCCCCCCEEEHHEEEECCCCCCHHHHHHHHCCCC--CCCCCC-- T ss_conf 09758985---47764238999999---998860765456220010000340588881455675433654--357876-- Q ss_pred CCCCCCC--CCCCCCCCCCCCCHHHHHHHCCCHHEECCCHHHHHHH Q ss_conf 5522357--8622330310022022032013201001001789999 Q Fun_Sc_NP_0140 258 ARYMDFI--PTIDKIREDRKTTSGIDLDKLYPLEVFKVNIQEELGK 301 (312) Q Consensus 258 ~~~ed~i--p~i~k~~~~~~~~~~~d~~~l~~~q~~~~~~q~~l~~ 301 (312) +||||| |+|||.+|++++.||+| |+|++|+|++|++ T Consensus 328 -~~ed~i~kp~~rk~~~~~ei~aedd-------Q~Fl~k~q~~l~~ 365 (475) T pfam05783 328 -AYEDIITKPPVRKVVHEKEIEAEDD-------QAFLMKLQSILAK 365 (475) T ss_pred -CCCCCCCCCCCHHHHHHHHHCCCHH-------HHHHHHHHHHHCC T ss_conf -4223447884023333332000127-------8999999999716 No 2 >KOG3905 Dynein light intermediate chain [Cell motility] Probab=100.00 E-value=0 Score=633.97 Aligned_columns=276 Identities=24% Q ss_pred CCCHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCE-EEEEEE Q ss_conf 8613889988641011465536644389975983317999998514778655665575025633562121332-688998 Q Fun_Sc_NP_0140 2 DNCNAWDKLLSQNESTINSTETATITAIIYSPSSKTLHQFINICFPEGSNSILDTTLINYATIGWTNDLKENY-SVDVYT 80 (312) Q Consensus 2 ~~~NlWs~iLse~~~~~~~k~~~~k~~lilg~~~~~~~~fi~~l~~~~~e~~~~~~~L~y~y~~v~~d~~d~~-R~~vy~ 80 (312) +||||||+||+||+++.++|+|++||+||+|+|++||+++|.++ ||+|.+|+|+||||+|++|+||+||++ ||+||+ T Consensus 29 egqnlWs~iLsev~T~~~sklpsgk~VlvlGdn~sGKtsLi~kl--qg~e~~KkgsgLeY~yl~V~de~RDd~tr~~VWi 106 (473) T KOG3905 29 EGQNLWSEILSEVSTRTRSKLPSGKNVLVLGDNGSGKTSLISKL--QGSETVKKGSGLEYLYLHVHDEDRDDLTRCNVWI 106 (473) T ss_pred HHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHH--HCCCCCCCCCCCEEEEEEECCCCHHHHHHCCCEE T ss_conf 77899999986542012344778865799705887457898876--3024567765312678862131004465487148 Q ss_pred EECCCHHHHHHHHHHHCCCC-CCCEEEEEECCCCCCHHHHHHHHHHHHHHHH---------------------------- Q ss_conf 60785435887887718778-7827999851666344689999999999864---------------------------- Q Fun_Sc_NP_0140 81 LIRNTDDALDLLKPFLQEHS-SKVRWLILLDWTLNDQKLWLNELSYAFNKIK---------------------------- 131 (312) Q Consensus 81 L~~~~~~~~~LLkp~L~~~s-~~~l~ViLLDWs~~Dp~~Wlr~Lr~~~~~L~---------------------------- 131 (312) |+|+.+|+. |||++|.+.+ .++++++..|+++ ||+|+..|..|...++ T Consensus 107 LDGd~~h~~-LLk~al~ats~aetlviltasms~--Pw~~lesLqkWa~Vl~ehidkl~i~~ee~ka~rqk~~k~wQeYv 183 (473) T KOG3905 107 LDGDLYHKG-LLKFALPATSLAETLVILTASMSN--PWTLLESLQKWASVLREHIDKLKIPPEEMKAGRQKLEKDWQEYV 183 (473) T ss_pred ECCCHHHHH-HHHHCCCCCCCCCEEEEEEEECCC--CHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHC T ss_conf 718755521-243204655615458989986575--03589999999999999898625898999999999888889760 Q ss_pred ---------------------------CCCCCC-------CEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH Q ss_conf ---------------------------068998-------7389984773456655324541157889999999999988 Q Fun_Sc_NP_0140 132 ---------------------------QLNDDN-------EFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYF 177 (312) Q Consensus 132 ---------------------------~l~~Dt-------~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~ 177 (312) .++.|+ +++|||+|||+|++|||+| +|+|||||||||+||+|||+ T Consensus 184 ep~e~~pgsp~~r~t~~~~~~de~~llPL~~dtLt~NlGi~vlVV~TK~D~~s~leke~-eyrDehfdfiq~~lRkFCLr 262 (473) T KOG3905 184 EPGEDQPGSPQRRTTVVGSSADEHVLLPLGQDTLTHNLGIPVLVVCTKCDAVSVLEKEH-EYRDEHFDFIQSHLRKFCLR 262 (473) T ss_pred CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCEEEEEECCCHHHHHHHCC-CCCHHHHHHHHHHHHHHHHH T ss_conf 51247888862034333565531111226776200006874799984243033455201-00167899999999999986 Q ss_pred CCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCEEECCCCCHHHHHHHHCCCCCCCCCCCCCCC Q ss_conf 29415885256531355566778888753001247787752240115630206688814624200478874400643467 Q Fun_Sc_NP_0140 178 NDSSLFYICEDHTEEKREEAQRLKYQELLKHFCEDRDMKDHIEMVTRSEILIPKGCDSIGLIKTVDERFEPTEVKEQHFL 257 (312) Q Consensus 178 yGASLiYts~ts~~~~kn~~~~l~y~~L~~h~l~~~~~~~~a~vverd~vfIP~GwDS~~KI~ii~E~F~~~~V~~~d~~ 257 (312) |||+|||| ||+|.||+++++|| ++|+.||++|+++|.|||||+||||+||||++||.||||||+ +|+.+| T Consensus 263 ~GaaLiyT---SvKE~KNidllyKY---ivhr~yG~~fttpAlVVEkdaVfIPAGWD~eKKI~Il~En~~--~vkaed-- 332 (473) T KOG3905 263 YGAALIYT---SVKETKNIDLLYKY---IVHRSYGFPFTTPALVVEKDAVFIPAGWDNEKKIDILHENFP--TVKAED-- 332 (473) T ss_pred CCCEEEEE---ECCCCCCHHHHHHH---HHHHHCCCCCCCHHHEEECCEEEECCCCCCCCHHHHHHCCCC--CCCCCC-- T ss_conf 06302554---11124556888888---887641553135001232031463046686300221000356--778776-- Q ss_pred CCCCCCC--CCCCCCCCCCCCCHHHHHHHCCCHHEECCCHHHHHHH Q ss_conf 5522357--8622330310022022032013201001001789999 Q Fun_Sc_NP_0140 258 ARYMDFI--PTIDKIREDRKTTSGIDLDKLYPLEVFKVNIQEELGK 301 (312) Q Consensus 258 ~~~ed~i--p~i~k~~~~~~~~~~~d~~~l~~~q~~~~~~q~~l~~ 301 (312) +|+||| ||+||+||++++.||+| |+|+||+|+.|++ T Consensus 333 -~y~d~itkpp~Rk~v~ekei~aEdd-------QaFL~k~q~iLak 370 (473) T KOG3905 333 -NYEDIITKPPVRKVVHEKEIEAEDD-------QAFLMKLQSILAK 370 (473) T ss_pred -CCCCCCCCCCCHHHHHHHHHHHHHH-------HHHHHHHHHHHHC T ss_conf -5332436884015666665410137-------8999999998605 No 3 >PF05783 DLIC: Dynein light intermediate chain (DLIC); InterPro: IPR008467 This family consists of several eukaryotic dynein light intermediate chain proteins. The light intermediate chains (LICs) of cytoplasmic dynein consist of multiple isoforms, which undergo post-translational modification to produce a large number of species. DLIC1 is known to be involved in assembly, organisation, and function of centrosomes and mitotic spindles when bound to pericentrin. DLIC2 is a subunit of cytoplasmic dynein 2 that may play a role in maintaining Golgi organisation by binding cytoplasmic dynein 2 to its Golgi-associated cargo .; GO: 0003774 motor activity Probab=100.00 E-value=0 Score=624.68 Aligned_columns=276 Identities=25% Q ss_pred CCCHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCC-EEEEECCCCCCCC-------- Q ss_conf 8613889988641011465536644389975983317999998514778655665575-0256335621213-------- Q Fun_Sc_NP_0140 2 DNCNAWDKLLSQNESTINSTETATITAIIYSPSSKTLHQFINICFPEGSNSILDTTLI-NYATIGWTNDLKE-------- 72 (312) Q Consensus 2 ~~~NlWs~iLse~~~~~~~k~~~~k~~lilg~~~~~~~~fi~~l~~~~~e~~~~~~~L-~y~y~~v~~d~~d-------- 72 (312) +++|||++||+|+++++++|+|++||++|+|+++.||+++|+++ ||+|+++|++|| +|+|++|+||+|| T Consensus 24 e~~~lWs~iL~evst~~~sklp~gk~vlVLGd~~sGKttLlakL--qg~e~~~Kg~gLleY~yl~v~dd~RD~~~~~~~~ 101 (525) T PF05783_consen 24 EKENLWSSILSEVSTRSNSKLPSGKNVLVLGDNGSGKTTLLAKL--QGVEETKKGRGLLEYLYLNVHDDDRDASYAYQLG 101 (525) T ss_pred HHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCHHHHHHHH--HCCCCCCCCCCCCCEEEEEEEHHHHHHHHHHHCC T ss_conf 54338899988754124510578861688617887678999987--2344344676411134653110101212100000 Q ss_pred ---------CE-EEEEEEEECCCHHHHHHHHHHHCCCC-CCCEEEEEECCCCCCHHHHHHHHHHHHHHHH---------- Q ss_conf ---------32-68899860785435887887718778-7827999851666344689999999999864---------- Q Fun_Sc_NP_0140 73 ---------NY-SVDVYTLIRNTDDALDLLKPFLQEHS-SKVRWLILLDWTLNDQKLWLNELSYAFNKIK---------- 131 (312) Q Consensus 73 ---------~~-R~~vy~L~~~~~~~~~LLkp~L~~~s-~~~l~ViLLDWs~~Dp~~Wlr~Lr~~~~~L~---------- 131 (312) ++ ||+||+|+|+.+|. .|||++|++++ .++++||.+||++ ||.|+.+|-.|...|+ T Consensus 102 ~~~~~~~p~d~tR~nVWiLdGd~~h~-~LLKfAl~~~s~~~tlvilt~dms~--PW~~mesLqkW~~Vl~ehi~kLki~~ 178 (525) T PF05783_consen 102 TAGANLNPSDLTRLNVWILDGDAYHK-GLLKFALNAESIADTLVILTLDMSR--PWNLMESLQKWASVLREHIDKLKIPP 178 (525) T ss_pred CCCCCCCCCCCCCCCEEEECCCCCCC-CCCCCCCCCCCCCCEEEEEEEECCC--HHHHHHHHHHHHHHHHHHHHHCCCCH T ss_conf 00011233310115515761752555-5544436854403458888753101--03589999999999999996057898 Q ss_pred ---------------------------------------------CCCCCC-------CEEEEEECCCHHHHHHHCCCCC Q ss_conf ---------------------------------------------068998-------7389984773456655324541 Q Fun_Sc_NP_0140 132 ---------------------------------------------QLNDDN-------EFSVWCLNSGEILNLQRHTTVW 159 (312) Q Consensus 132 ---------------------------------------------~l~~Dt-------~i~VVc~~sD~i~~LEKe~~~w 159 (312) .+++.+ +++|||+|||+|.+||||| +| T Consensus 179 E~~~~meqrl~k~~QeY~EP~~~~~~sPqrr~~~~~s~~de~v~LPL~~g~Lt~NLGipi~VVctk~D~i~~LeKe~-d~ 257 (525) T PF05783_consen 179 EELKEMEQRLVKKFQEYVEPGEDLDGSPQRRTTVVSSSDDESVLLPLGEGTLTENLGIPIIVVCTKSDAISVLEKEH-DY 257 (525) T ss_pred HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHCC-CC T ss_conf 99999999999987643161336888841056778754433232668866411478951799850775134444204-75 Q ss_pred CHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCEEECCCCCHHHHH Q ss_conf 15788999999999998829415885256531355566778888753001247787752240115630206688814624 Q Fun_Sc_NP_0140 160 QSVHIDFILQTLRSFCYFNDSSLFYICEDHTEEKREEAQRLKYQELLKHFCEDRDMKDHIEMVTRSEILIPKGCDSIGLI 239 (312) Q Consensus 160 ~de~fDfIqQ~LRtvcL~yGASLiYts~ts~~~~kn~~~~l~y~~L~~h~l~~~~~~~~a~vverd~vfIP~GwDS~~KI 239 (312) +|||||||||+||+|||+|||||||| ++++.+|++++++| ++|++|+|||+.+|.|||+|+||||+||||++|| T Consensus 258 kdE~fDfIqq~lR~fcL~yGAsLiYT---SvKe~kN~dllykY---i~HrlYgf~f~~~a~vvekdavfiPaGwDn~kKI 331 (525) T PF05783_consen 258 KDEHFDFIQQHLRRFCLQYGASLIYT---SVKEEKNIDLLYKY---IVHRLYGFPFKTPAQVVEKDAVFIPAGWDNLKKI 331 (525) T ss_pred CHHHHHHHHHHHHHHHHHCCCEEEEE---ECCCCCCHHHHHHH---HHHHHCCCCCCCCCEEEECCCEEECCCCCCHHHH T ss_conf 27789999999999997607404674---04552108999999---9887607755774303410001203676511333 Q ss_pred HHHCCCCCCCCCCCCCCCCCCCCCC--CCCCCCCC--CCCCCHHHHHHHCCCHHEECCCHHHHHHH Q ss_conf 2004788744006434675522357--86223303--10022022032013201001001789999 Q Fun_Sc_NP_0140 240 KTVDERFEPTEVKEQHFLARYMDFI--PTIDKIRE--DRKTTSGIDLDKLYPLEVFKVNIQEELGK 301 (312) Q Consensus 240 ~ii~E~F~~~~V~~~d~~~~~ed~i--p~i~k~~~--~~~~~~~~d~~~l~~~q~~~~~~q~~l~~ 301 (312) .||||||+ +|+++| +||||| |||||++| ++++.||+| |+|++|+|++|++ T Consensus 332 ~Il~En~~--~~K~dd---~~ed~i~kpp~rk~v~~re~ei~aEdd-------Q~FL~k~qs~La~ 385 (525) T PF05783_consen 332 SILHENFQ--TVKPDD---PYEDIITKPPVRKLVHNREKEIQAEDD-------QVFLMKQQSLLAK 385 (525) T ss_pred HHHHHCCC--CCCCCC---CCCCCCCCCCCCCHHHHHHHHHHCCCH-------HHHHHHHHHHHHC T ss_conf 44320334--466654---323321268633001122455411206-------8999999998614 No 4 >PTHR12688 DYNEIN LIGHT INTERMEDIATE CHAIN; InterPro: IPR008467 This family consists of several eukaryotic dynein light intermediate chain proteins. The light intermediate chains (LICs) of cytoplasmic dynein consist of multiple isoforms, which undergo post-translational modification to produce a large number of species. DLIC1 is known to be involved in assembly, organisation, and function of centrosomes and mitotic spindles when bound to pericentrin. DLIC2 is a subunit of cytoplasmic dynein 2 that may play a role in maintaining Golgi organisation by binding cytoplasmic dynein 2 to its Golgi-associated cargo .; GO: 0003774 motor activity. Probab=100.00 E-value=0 Score=471.81 Aligned_columns=222 Identities=25% Q ss_pred CCEEEEECCCCCCCCCE-EEEEEEEECCCHHHHHHHHHHHCCCC-CCCEEEEEECCCCCCHHHHHHHHHHHHHHHH---- Q ss_conf 75025633562121332-68899860785435887887718778-7827999851666344689999999999864---- Q Fun_Sc_NP_0140 58 LINYATIGWTNDLKENY-SVDVYTLIRNTDDALDLLKPFLQEHS-SKVRWLILLDWTLNDQKLWLNELSYAFNKIK---- 131 (312) Q Consensus 58 ~L~y~y~~v~~d~~d~~-R~~vy~L~~~~~~~~~LLkp~L~~~s-~~~l~ViLLDWs~~Dp~~Wlr~Lr~~~~~L~---- 131 (312) |++|+|.+|+++++|++ ||+||+|+++.++.+ |||+++.+++ ++|+++|++||++ ||+|+++|..|...|+ T Consensus 1 g~~Y~y~~v~d~d~d~~~r~~vW~Ldgd~~~~g-Llk~a~~~~s~~~tl~~~~~dm~~--PW~~~~~L~~W~~v~~~~~~ 77 (415) T PTHR12688 1 GLEYLYLNVHDEDRDDLTRCNVWILDGDLYHKG-LLKFALSAESLPDTLVILVADMSK--PWTVMDSLQKWASVLREHID 77 (415) T ss_pred CCCHHHHHHHHCCHHHHHHCCCEEECCCHHHHH-HHHHHCCHHHHHHHHHHHHHHHHC--CHHHHHHHHHHHHHHHHHHH T ss_conf 920132201103601343210103435276777-888631730178999999998722--55799999999999999998 Q ss_pred ---------------------------------------------CCCCCC-------CEEEEEECCCHHHHHHHCCCCC Q ss_conf ---------------------------------------------068998-------7389984773456655324541 Q Fun_Sc_NP_0140 132 ---------------------------------------------QLNDDN-------EFSVWCLNSGEILNLQRHTTVW 159 (312) Q Consensus 132 ---------------------------------------------~l~~Dt-------~i~VVc~~sD~i~~LEKe~~~w 159 (312) .++.++ +++|||++||.|..||||| +| T Consensus 78 kl~i~~~~~~~~~~~~~~~~q~y~e~~~~~~~s~~~~~~d~~~~lp~~~~~lt~nlG~~~~vV~~k~d~~~~L~ke~-dy 156 (415) T PTHR12688 78 KLKIPPEEMKELEQKLVKDFQEYVEPGEGLPGSPLRRNADELVPLPLGEGTLTHNLGIPVVVVCTKSDAMSVLEKEH-DY 156 (415) T ss_pred HHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHCCCEEEEEEECCHHHHHHHHHC-CC T ss_conf 73388889999999999975421020013333420112344431234124677637916999874131578875430-31 Q ss_pred CHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCEEECCCCCHHHHH Q ss_conf 15788999999999998829415885256531355566778888753001247787752240115630206688814624 Q Fun_Sc_NP_0140 160 QSVHIDFILQTLRSFCYFNDSSLFYICEDHTEEKREEAQRLKYQELLKHFCEDRDMKDHIEMVTRSEILIPKGCDSIGLI 239 (312) Q Consensus 160 ~de~fDfIqQ~LRtvcL~yGASLiYts~ts~~~~kn~~~~l~y~~L~~h~l~~~~~~~~a~vverd~vfIP~GwDS~~KI 239 (312) ++|||||||++||+|||+|||||||| ++++.||+++++|| ++|++|||+|+.+|.|||||+||||+|||+++|| T Consensus 157 rdehfDfiq~~lR~fcL~yga~L~yt---svke~kN~dLlykY---ivh~~yGf~f~~~a~VvekdavfiPaGWD~~kKI 230 (415) T PTHR12688 157 RDEHFDFIQSHLRKFCLQYGAALIYT---SVKEEKNIDLLYKY---IVHKLYGFPFTIPALVVEKDAVFIPAGWDNEKKI 230 (415) T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHH---HHHHHHHHHHHHHH---HHHHHCCCCCCCHHHEEEEEEEEECCCCCCHHHH T ss_conf 28899999999999999840253110---10013348999999---9888606543440111220004516898807788 Q ss_pred HHHCCCCCCCCCCCCCCCCCCCCCC--CCCCCCCCCCCCCHHHHHHHCCCHHEECCCHHHHHHH Q ss_conf 2004788744006434675522357--8622330310022022032013201001001789999 Q Fun_Sc_NP_0140 240 KTVDERFEPTEVKEQHFLARYMDFI--PTIDKIREDRKTTSGIDLDKLYPLEVFKVNIQEELGK 301 (312) Q Consensus 240 ~ii~E~F~~~~V~~~d~~~~~ed~i--p~i~k~~~~~~~~~~~d~~~l~~~q~~~~~~q~~l~~ 301 (312) .||||||+ +|+++| .|||+| |||||++|++++.||++ |+|+|++|+.|++ T Consensus 231 ~il~enf~--~~~~~d---~y~d~i~~P~~Rk~v~~~~~~aed~-------Q~fl~k~~~~l~~ 282 (415) T PTHR12688 231 GILHENFT--TVKPED---AYEDIIVKPPVRKLVHEKEIAAEDE-------QVFLMKQQSLLAK 282 (415) T ss_pred HHHHCCCC--CCCCCC---CCCCCCCCCCCCHHHHHHHHHHHHH-------HHHHHHHHHHHHH T ss_conf 98760520--024442---1011025785012345888754467-------7899999999852 No 5 >PTHR13236 DYNEIN 2 LIGHT INTERMEDIATE CHAIN, ISOFORM 2. Probab=99.47 E-value=3e-12 Score=95.00 Aligned_columns=226 Identities=18% Q ss_pred CCCCHHHHHHHHH------HCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCE Q ss_conf 9861388998864------1011465536644389975983317999998514778655665575025633562121332 Q Fun_Sc_NP_0140 1 MDNCNAWDKLLSQ------NESTINSTETATITAIIYSPSSKTLHQFINICFPEGSNSILDTTLINYATIGWTNDLKENY 74 (312) Q Consensus 1 ~~~~NlWs~iLse------~~~~~~~k~~~~k~~lilg~~~~~~~~fi~~l~~~~~e~~~~~~~L~y~y~~v~~d~~d~~ 74 (312) |.+.++|.---.+ |.+..++.++.+|++...|--..|||++|.+| .+--|++++..+|||+|---..-....- T Consensus 10 ~~~e~lw~~A~~~~e~rg~~g~~gdg~e~~e~~~ffiGsk~gGKttiilr~-ldrde~~kPtlaLEYtygRr~~g~~~~K 88 (397) T PTHR13236 10 MPSETLWEIAKAEVEKRGINGSEGDGAEIAEKFVFFIGSKNGGKTTIILRC-LDRDEPPKPTLALEYTYGRRAKGHNTPK 88 (397) T ss_pred CCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEEECCCCHHHHHHHH-HCCCCCCCCCEEEEECHHHHHCCCCCCC T ss_conf 676658999999998515675411353001016888873488546677656-3234567874000000111104688853 Q ss_pred -EEEEEEEECCCHHHHHHHHHHHCCCC-CCCEEEEEECCCCCCH-HH----HHHHHHHHHHHHHCCCCCCC--------- Q ss_conf -68899860785435887887718778-7827999851666344-68----99999999998640689987--------- Q Fun_Sc_NP_0140 75 -SVDVYTLIRNTDDALDLLKPFLQEHS-SKVRWLILLDWTLNDQ-KL----WLNELSYAFNKIKQLNDDNE--------- 138 (312) Q Consensus 75 -R~~vy~L~~~~~~~~~LLkp~L~~~s-~~~l~ViLLDWs~~Dp-~~----Wlr~Lr~~~~~L~~l~~Dt~--------- 138 (312) =..+|-|-|-... .+|+.-.++.++ ..-.+|++||.|.++. |. ++..++.++.+.......+. T Consensus 89 diah~WELGGg~~~-~~li~iPit~~~l~~~~~~lvLDlS~p~~~w~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~r~ 167 (397) T PTHR13236 89 DIAHFWELGGGTSL-LDLISIPITGDTLRTFSLVLVLDLSKPNDLWPTLENLLQATKSHVDKVLLKLGKTNAKAVSEMRQ 167 (397) T ss_pred CEEEEEECCCCCCH-HHHHHHCCCCHHHHHEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_conf 03565531774245-77864122301253120110440576400245499999999999999999852013567898888 Q ss_pred -------------------------------------------------EEEEEECCCHHHHHHHCCCCCCHHHHHHHHH Q ss_conf -------------------------------------------------3899847734566553245411578899999 Q Fun_Sc_NP_0140 139 -------------------------------------------------FSVWCLNSGEILNLQRHTTVWQSVHIDFILQ 169 (312) Q Consensus 139 -------------------------------------------------i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ 169 (312) +++|-.+-|....-+-+.. ..+++ T Consensus 168 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~p~~~~i~g~kyD~f~~~~~e~r-------k~~~~ 240 (397) T PTHR13236 168 RIWNNMPKDHPVSCCLGLLLESLVPFIVNDNITGNAFPDLELVDPFPIPLVIVGSKYDVFQDFDSEKR-------KVICR 240 (397) T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHCCCCHHHH-------HHHHH T ss_conf 88742001246899999999888888888777643202356551078116885201101105446789-------99999 Q ss_pred HHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCEEECCCCCHHHHHHH Q ss_conf 999999882941588525653135556677888875300124778775224011563020668881462420 Q Fun_Sc_NP_0140 170 TLRSFCYFNDSSLFYICEDHTEEKREEAQRLKYQELLKHFCEDRDMKDHIEMVTRSEILIPKGCDSIGLIKT 241 (312) Q Consensus 170 ~LRtvcL~yGASLiYts~ts~~~~kn~~~~l~y~~L~~h~l~~~~~~~~a~vverd~vfIP~GwDS~~KI~i 241 (312) .||.+.+.+||+|+|.+. ++..+.......+.|..++.+......+....+++||.|.||+.+|.. T Consensus 241 ~Lr~~ah~~Ga~L~~~s~------~~~~l~~~~~~~~~~l~Fg~~~~~~~~~~~~~P~~~~~g~d~~~~~g~ 306 (397) T PTHR13236 241 TLRFLAHAYGASLLFLSS------KSEALLKKVRGVINHLAFGSPLPKSILVDHNKPLAIPAGLDSLAKIGL 306 (397) T ss_pred HHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHCCC T ss_conf 999999974368767742------258999999999988863035667765204577168706134766067 No 6 >KOG3929 Uncharacterized conserved protein [Function unknown] Probab=99.38 E-value=5e-13 Score=99.59 Aligned_columns=255 Identities=19% Q ss_pred HHHCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHH Q ss_conf 64101146553664438997598331799999851477865566557502563356212133268899860785435887 Q Fun_Sc_NP_0140 12 SQNESTINSTETATITAIIYSPSSKTLHQFINICFPEGSNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDL 91 (312) Q Consensus 12 se~~~~~~~k~~~~k~~lilg~~~~~~~~fi~~l~~~~~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~L 91 (312) ++-+.+......+-...++.-+|..- ++.|.+||.-.-...-....|||+|---..--.--.-.++|-|-|-... .+| T Consensus 31 ~~~deqL~e~~~~~E~~I~~~Gn~~~-tt~I~~~FdR~e~~~~ptlaLEYtygRR~~g~~~kdiaN~WELGgg~~~-~~L 108 (363) T KOG3929 31 SEGDEQLAEIAEKFEFFIGSKGNGGK-TTIILRCFDRDEPPKPPTLALEYTYGRRAKGHNPKDIANFWELGGGTSL-LDL 108 (363) T ss_pred CHHHHHHHHHHCCHHCEEEEECCCCE-EEEEEECCCCCCCCCCCCEEEEEHHHHHHCCCCCHHHHHHHHCCCCCCH-HHH T ss_conf 21378999850300205677338850-6653300576567899721221012344147885145655532673246-888 Q ss_pred HHHHHCCCC-CCCEEEEEECCCCCCH-HHH------HHHHHHHHHHHH-----------------------------CCC Q ss_conf 887718778-7827999851666344-689------999999999864-----------------------------068 Q Fun_Sc_NP_0140 92 LKPFLQEHS-SKVRWLILLDWTLNDQ-KLW------LNELSYAFNKIK-----------------------------QLN 134 (312) Q Consensus 92 Lkp~L~~~s-~~~l~ViLLDWs~~Dp-~~W------lr~Lr~~~~~L~-----------------------------~l~ 134 (312) |..-++.++ ..-.++++||.|+ | ..| +.-+|.+++.+. +.- T Consensus 109 LsVPit~~~l~~~slIL~LDls~--p~~~W~t~E~~~~~~R~~vd~~~~~~~k~~~~L~E~mrqR~~~rvgqd~~d~e~~ 186 (363) T KOG3929 109 LSVPITGDTLRTFSLILVLDLSK--PNDLWPTMENLLQATRSHVDKVIMKLGKTNAKLVEEMRQRIWNRVGQDHPDHELI 186 (363) T ss_pred HHCCCCCCCHHHHHHHHHHHCCC--HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCC T ss_conf 60554556287756667651156--2443257999999999899999998741488999999999998621468740002 Q ss_pred CCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCC Q ss_conf 99873899847734566553245411578899999999999882941588525653135556677888875300124778 Q Fun_Sc_NP_0140 135 DDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSLFYICEDHTEEKREEAQRLKYQELLKHFCEDRD 214 (312) Q Consensus 135 ~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGASLiYts~ts~~~~kn~~~~l~y~~L~~h~l~~~~ 214 (312) ++.++-|+.-.+-|=.- .++.++-=--++|+||++++.|||+|.+-|. |-..+.-+-+..+.|..+|-+ T Consensus 187 dP~P~PV~IVgsKYDvF-----q~FesekRkH~C~~LRf~Ah~yGaaLlmfSs------kMe~l~K~ir~~i~HlaFG~~ 255 (363) T KOG3929 187 DPFPVPVVIVGSKYDVF-----QDFESEKRKHICKTLRFVAHYYGAALLMFSS------KMEALLKKIRGVINHLAFGID 255 (363) T ss_pred CCCCCCEEEECCCCHHH-----CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH------HHHHHHHHHHHHHHHHHCCCC T ss_conf 77885347853520001-----2663678999999999999997789999888------789999998777775404765 Q ss_pred CCCCCCEECCCCEEECCCCCHHHHHHHHCCCCCCCCCCCCCCC--CCCCCCCCCCCCCCCCCCCCHHHHHHHCCCH Q ss_conf 7752240115630206688814624200478874400643467--5522357862233031002202203201320 Q Fun_Sc_NP_0140 215 MKDHIEMVTRSEILIPKGCDSIGLIKTVDERFEPTEVKEQHFL--ARYMDFIPTIDKIREDRKTTSGIDLDKLYPL 288 (312) Q Consensus 215 ~~~~a~vverd~vfIP~GwDS~~KI~ii~E~F~~~~V~~~d~~--~~~ed~ip~i~k~~~~~~~~~~~d~~~l~~~ 288 (312) -.+...|....++||-+|-|||++|++ --|.++|.+ -++|-.--+..+.++++.+.-.-|.+.--|+ T Consensus 256 ~~~s~~vD~NkPlfi~~G~DS~~~IG~-------pp~~~nd~Ga~sp~elw~~~F~~l~PQk~~~~~kd~kttDPa 324 (363) T KOG3929 256 KSKSICVDQNKPLFITAGLDSFGQIGS-------PPVPENDIGAHSPMELWKKVFEKLFPQKSINTLKDIKTTDPA 324 (363) T ss_pred CCCCEEEECCCCEEEEECCCCHHHCCC-------CCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCC T ss_conf 766545307874589855532233378-------888743345433378999999863341234555554301533 No 7 >2q3h_A RAS homolog gene family, member U; GTPase, structural genomics, structural genomics consortium, SGC; HET: GDP; 1.73A {Homo sapiens} Probab=98.29 E-value=6.6e-05 Score=51.50 Aligned_columns=191 Identities=6% Q ss_pred HHHCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHH Q ss_conf 64101146553664438997598331799999851477865566557502563356212133268899860785435887 Q Fun_Sc_NP_0140 12 SQNESTINSTETATITAIIYSPSSKTLHQFINICFPEGSNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDL 91 (312) Q Consensus 12 se~~~~~~~k~~~~k~~lilg~~~~~~~~fi~~l~~~~~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~L 91 (312) ++++.++++.+.....++++|+.+.||++|++++......+........+....+..+ ....++.+|-..+.... ..+ T Consensus 7 ~~~~~~~~~~~~k~iKV~iiG~~gvGKTsLi~~l~~~~~~~~~~~t~~~~~~~~~~~~-~~~~~l~i~D~~g~~~~-~~~ 84 (201) T 2q3h_A 7 PGGRGRAGGAEGRGVKCVLVGDGAVGKTSLVVSYTTNGYPTEYIPTAFDNFSAVVSVD-GRPVRLQLCDTAGQDEF-DKL 84 (201) T ss_dssp -------------CEEEEEECSTTSSHHHHHHHHHC--------CCSSEEEEEEEEET-TEEEEEEEEECCCSTTC-SSS T ss_pred CCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEEC-CEEEEEEECCCCCCHHH-CCC T ss_conf 7777788888887248998707997789999998717656553422555789999860-60566530346520011-001 Q ss_pred HHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHH Q ss_conf 88771877878279998516663446899999999998640689987389984773456655324541157889999999 Q Fun_Sc_NP_0140 92 LKPFLQEHSSKVRWLILLDWTLNDQKLWLNELSYAFNKIKQLNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTL 171 (312) Q Consensus 92 Lkp~L~~~s~~~l~ViLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~L 171 (312) .+.++ +.-..+++..|-+ |+..+......|...++.....-++++|+.|+|....-....-......-....+.. T Consensus 85 ~~~~~---~~a~~~iiV~d~~--~~~Sf~~~~~~~~~~i~~~~~~~piiivgnK~D~~~~~~~~~~~~~~~~~~i~~~~~ 159 (201) T 2q3h_A 85 RPLCY---TNTDIFLLCFSVV--SPSSFQNVSEKWVPEIRCHCPKAPIILVGTQSDLREDVKVLIELDKCKEKPVPEEAA 159 (201) T ss_dssp GGGGG---TTCSEEEEEEETT--CHHHHHHHHHTHHHHHHHHCSSSCEEEEEECGGGGGCHHHHHHHHTTTCCCCCHHHH T ss_pred CCCHH---HHHHHCCEEEECC--CHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCHHHH T ss_conf 20010---0122122112113--166677899987655543067736888611478411356777765531255778999 Q ss_pred HHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHC Q ss_conf 99998829415885256531355566778888753001 Q Fun_Sc_NP_0140 172 RSFCYFNDSSLFYICEDHTEEKREEAQRLKYQELLKHF 209 (312) Q Consensus 172 RtvcL~yGASLiYts~ts~~~~kn~~~~l~y~~L~~h~ 209 (312) +.+|-.+++-.++-+.....+..+++.-......+-|+ T Consensus 160 ~~~~~~~~~~~~~e~Sak~~~gI~e~f~~ii~~al~~~ 197 (201) T 2q3h_A 160 KLLAEEIKAASYIECSALTQKNLKEVFDAAIVAGIQYS 197 (201) T ss_dssp HHHHHHHTCSEEEECCTTTCTTHHHHHHHHHHHHHHHH T ss_pred HHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCC T ss_conf 99999708953899851588787899999999998500 No 8 >cd04101 RabL4 RabL4 (Rab-like4) subfamily. RabL4s are novel proteins that have high sequence similarity with Rab family members, but display features that are distinct from Rabs, and have been termed Rab-like. As in other Rab-like proteins, RabL4 lacks a prenylation site at the C-terminus. The specific function of RabL4 remains unknown. Probab=98.02 E-value=0.0023 Score=42.38 Aligned_columns=159 Identities=13% Q ss_pred EEEECCCCHHHHHHHHHHCCCCCCCCCC---CCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCCCCE Q ss_conf 8997598331799999851477865566---5575025633562121332688998607854358878877187787827 Q Fun_Sc_NP_0140 28 AIIYSPSSKTLHQFINICFPEGSNSILD---TTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHSSKVR 104 (312) Q Consensus 28 ~lilg~~~~~~~~fi~~l~~~~~e~~~~---~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s~~~l 104 (312) ++++|+.+-|||+|+.+...+|.+++.+ +.+.+|....+.-+..+...+..|=..| ...+..+.+..+. .-.- T Consensus 3 vv~iGd~~VGKTsli~~~~~~~~~f~~~y~~T~~~~~~~~~~~i~~~~~~~l~i~DtaG-qe~~~~~~~~~~~---~a~~ 78 (164) T cd04101 3 CAVVGDPAVGKTAFVQMFHSNGAVFPKNYLMTTGCDFVVKEVPVDTDNTVELFIFDSAG-QELYSDMVSNYWE---SPSV 78 (164) T ss_pred EEEEECCCCCHHHHHHHHHHCCCEECCCCCCCEEEEEEEEEEEECCCCEEEEEEEECCC-CHHHHHHHHHHCC---CCCE T ss_conf 89980798218988887761684416665431124567999997799679999960387-2246788787424---9976 Q ss_pred EEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEE Q ss_conf 99985166634468999999999986406899873899847734566553245411578899999999999882941588 Q Fun_Sc_NP_0140 105 WLILLDWTLNDQKLWLNELSYAFNKIKQLNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSLFY 184 (312) Q Consensus 105 ~ViLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGASLiY 184 (312) +++.-|-+. +...-+. ..|+..++....+.++++|..|+| |+..+ .-.+++ .|.+|-.+|+..|. T Consensus 79 ~ilvydit~--~~Sf~~i-~~w~~~i~~~~~~~p~ilVGNK~D----L~~~r-~V~~~~-------~~~~a~~~~~~~~e 143 (164) T cd04101 79 FILVYDVSN--KASFENC-SRWVNKVRTASKHMPGVLVGNKMD----LADKA-EVTDAQ-------AQAFAQANQLKFFK 143 (164) T ss_pred EEEEEECCC--HHHHHHH-HHHHHHHHHHCCCCEEEEEECCCC----CCCCC-CCCHHH-------HHHHHHHCCCCEEE T ss_conf 999941799--7689999-999999998449973999821434----00116-789899-------99999963994999 Q ss_pred ECCCCCHHHHHHHHHHHHHHHHHH Q ss_conf 525653135556677888875300 Q Fun_Sc_NP_0140 185 ICEDHTEEKREEAQRLKYQELLKH 208 (312) Q Consensus 185 ts~ts~~~~kn~~~~l~y~~L~~h 208 (312) + |+++..|-...+..-+-..| T Consensus 144 ~---SAktg~nV~e~F~~lar~~~ 164 (164) T cd04101 144 T---SALRGVGYEEPFESLARAFH 164 (164) T ss_pred E---ECCCCCCHHHHHHHHHHHHC T ss_conf 9---71689887899999999729 No 9 >1ek0_A GTP-binding protein YPT51; vesicular traffic, GTP hydrolysis, YPT/RAB protein, endocytosis, hydrolase; HET: MHO GNP GDP; 1.48A {Saccharomyces cerevisiae} SCOP: c.37.1.8 Probab=97.93 E-value=0.0073 Score=39.37 Aligned_columns=166 Identities=7% Q ss_pred CCCEEEEECCCCHHHHHHHHHHCCCC-CCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCCC Q ss_conf 64438997598331799999851477-86556655750256335621213326889986078543588788771877878 Q Fun_Sc_NP_0140 24 ATITAIIYSPSSKTLHQFINICFPEG-SNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHSSK 102 (312) Q Consensus 24 ~~k~~lilg~~~~~~~~fi~~l~~~~-~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s~~ 102 (312) ++..++++|+.+.||++|+.++..+. .+.+.++.+.+|....+..+ ..+.++..|-..+.-.. ..+.+..+ +.- T Consensus 2 ~~iki~ivG~~~vGKSsLi~~~~~~~~~~~~~~t~~~~~~~~~~~~~-~~~~~l~i~d~~g~~~~-~~~~~~~~---~~~ 76 (170) T 1ek0_A 2 TSIKLVLLGEAAVGKSSIVLRFVSNDFAENKEPTIGAAFLTQRVTIN-EHTVKFEIWDTAGQERF-ASLAPXYY---RNA 76 (170) T ss_dssp EEEEEEEECSTTSSHHHHHHHHHHSCCCTTCCCCSSEEEEEEEEEET-TEEEEEEEEEECCSGGG-GGGHHHHH---TTC T ss_pred CEEEEEEECCCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEECCCC-CCCCCEEEECCCCCHHH-HHHHHHHC---CCC T ss_conf 65889988179977899999986483465534310234554200012-23430243034451123-22201112---565 Q ss_pred CEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEE Q ss_conf 27999851666344689999999999864068998738998477345665532454115788999999999998829415 Q Fun_Sc_NP_0140 103 VRWLILLDWTLNDQKLWLNELSYAFNKIKQLNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSL 182 (312) Q Consensus 103 ~l~ViLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGASL 182 (312) ..+++..|-+ |+..+...-..+-...+..+...+++||+.|+|....-.+......+ .+.++-.+|+.. T Consensus 77 ~~~i~v~d~~--~~~s~~~~~~~~~~~~~~~~~~~~iivv~nK~D~~~~~~~~~v~~~~---------~~~~~~~~~~~~ 145 (170) T 1ek0_A 77 QAALVVYDVT--KPQSFIKARHWVKELHEQASKDIIIALVGNKIDXLQEGGERKVAREE---------GEKLAEEKGLLF 145 (170) T ss_dssp SEEEEEEETT--CHHHHHHHHHHHHHHHHHSCTTCEEEEEEECGGGGGSSCCCCSCHHH---------HHHHHHHHTCEE T ss_pred CEEEEEEECC--CCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHH---------HHHHHHHCCCEE T ss_conf 0378997023--65045566788888864113564334541153100000001100789---------999998659839 Q ss_pred EEECCCCCHHHHHHHHHHHHHHHHHHCCC Q ss_conf 88525653135556677888875300124 Q Fun_Sc_NP_0140 183 FYICEDHTEEKREEAQRLKYQELLKHFCE 211 (312) Q Consensus 183 iYts~ts~~~~kn~~~~l~y~~L~~h~l~ 211 (312) +.+ |++...+-..++.. ++..+. T Consensus 146 ~e~---Sa~~~~gi~elf~~---i~~~i~ 168 (170) T 1ek0_A 146 FET---SAKTGENVNDVFLG---IGEKIP 168 (170) T ss_dssp EEC---CTTTCTTHHHHHHH---HHTTSC T ss_pred EEE---ECCCCCCHHHHHHH---HHHHHC T ss_conf 998---62688688899999---999706 No 10 >2hxs_A RAB-26, RAS-related protein RAB-28; GTPase, signaling protein; HET: G3D; 1.10A {Homo sapiens} Probab=97.88 E-value=0.0039 Score=41.01 Aligned_columns=176 Identities=9% Q ss_pred CCCCCCCEEEEECCCCHHHHHHHHHHCC-CCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCC Q ss_conf 5536644389975983317999998514-778655665575025633562121332688998607854358878877187 Q Fun_Sc_NP_0140 20 STETATITAIIYSPSSKTLHQFINICFP-EGSNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQE 98 (312) Q Consensus 20 ~k~~~~k~~lilg~~~~~~~~fi~~l~~-~~~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~ 98 (312) |.-...-.++++|..+.||++|++++.. .-.+.+.++.+.++....+.-+.....++.+|-..+..... .+.+..+.. T Consensus 1 ~~~~k~~ki~iiG~~~vGKSsli~~~~~~~~~~~~~~T~~~~~~~~~v~~~~~~~~~~~i~D~~g~~~~~-~~~~~~~~~ 79 (178) T 2hxs_A 1 GSHMRQLKIVVLGDGASGKTSLTTCFAQETFGKQYKQTIGLDFFLRRITLPGNLNVTLQIWDIGGQTIGG-KMLDKYIYG 79 (178) T ss_dssp CCCCCEEEEEEECCTTSSHHHHHHHHHGGGTTHHHHHTTTSSEEEEEEEETTTEEEEEEEEECTTCCTTC-TTHHHHHTT T ss_pred CCCCCEEEEEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEECCCCCEEEEEEEEECCCCCCCC-CCCCCCCCC T ss_conf 9865147899980799889999999862833776222255423545322320103567775314743122-112111210 Q ss_pred CCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEE-ECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH Q ss_conf 787827999851666344689999999999864068998738998-4773456655324541157889999999999988 Q Fun_Sc_NP_0140 99 HSSKVRWLILLDWTLNDQKLWLNELSYAFNKIKQLNDDNEFSVWC-LNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYF 177 (312) Q Consensus 99 ~s~~~l~ViLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~Dt~i~VVc-~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~ 177 (312) -..++++.|-+..+....+......+..+.+.....+..+++ .|+| |+.+. ....++. +.+|-+ T Consensus 80 ---~~~~i~v~d~~~~~s~~~~~~~~~~i~~~~~~~~~~~~iilV~nK~D----l~~~~-~v~~~~~-------~~~~~~ 144 (178) T 2hxs_A 80 ---AQGVLLVYDITNYQSFENLEDWYTVVKKVSEESETQPLVALVGNKID----LEHMR-TIKPEKH-------LRFCQE 144 (178) T ss_dssp ---CSEEEEEEETTCHHHHHTHHHHHHHHHHHHHHHTCCCEEEEEEECGG----GGGGC-SSCHHHH-------HHHHHH T ss_pred ---CCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCC----CHHHH-CCCHHHH-------HHHHHH T ss_conf ---00000132202455411012456777531002465630233302344----10222-0245889-------999996 Q ss_pred CCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCC Q ss_conf 2941588525653135556677888875300124778775 Q Fun_Sc_NP_0140 178 NDSSLFYICEDHTEEKREEAQRLKYQELLKHFCEDRDMKD 217 (312) Q Consensus 178 yGASLiYts~ts~~~~kn~~~~l~y~~L~~h~l~~~~~~~ 217 (312) +|+..+.+ |++...+-..++.. ++..+.+...++ T Consensus 145 ~~~~~~~~---Sa~~~~~I~e~f~~---i~~~i~~~~~~k 178 (178) T 2hxs_A 145 NGFSSHFV---SAKTGDSVFLCFQK---VAAEILGIKLNK 178 (178) T ss_dssp HTCEEEEE---CTTTCTTHHHHHHH---HHHHHTTCCCCC T ss_pred CCCEEEEE---ECCCCCCHHHHHHH---HHHHHHHHHCCC T ss_conf 49908999---61578788899999---999998621269 No 11 >cd04128 Spg1 Spg1p. Spg1p (septum-promoting GTPase) was first identified in the fission yeast S. pombe, where it regulates septum formation in the septation initiation network (SIN) through the cdc7 protein kinase. Spg1p is an essential gene that localizes to the spindle pole bodies. When GTP-bound, it binds cdc7 and causes it to translocate to spindle poles. Sid4p (septation initiation defective) is required for localization of Spg1p to the spindle pole body, and the ability of Spg1p to promote septum formation from any point in the cell cycle depends on Sid4p. Spg1p is negatively regulated by Byr4 and cdc16, which form a two-component GTPase activating protein (GAP) for Spg1p. The existence of a SIN-related pathway in plants has been proposed. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are Probab=97.85 E-value=0.0066 Score=39.61 Aligned_columns=170 Identities=12% Q ss_pred EEEECCCCHHHHHHHHHHCC-CCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCCCCEEE Q ss_conf 89975983317999998514-77865566557502563356212133268899860785435887887718778782799 Q Fun_Sc_NP_0140 28 AIIYSPSSKTLHQFINICFP-EGSNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHSSKVRWL 106 (312) Q Consensus 28 ~lilg~~~~~~~~fi~~l~~-~~~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s~~~l~V 106 (312) ++++|+.+-|||+++.+... +-.+.+....|++|....+.- ++..+.+-+.+...-+.-.-+.+..-.++. .++ T Consensus 3 ivliGd~~VGKTsLi~r~~~~~F~~~y~~TiG~~~~~k~i~v---~~~~v~l~iwDtaGqE~f~~~~~~y~~~a~--~~i 77 (182) T cd04128 3 IGLLGDAQIGKTSLMVKYVEGEFDEDYIQTLGVNFMEKTISI---RGTEITFSIWDLGGQREFINMLPLVCNDAV--AIL 77 (182) T ss_pred EEEEECCCCCHHHHHHHHHCCEECCCCCCEEEEEEEEEEEEE---CCEEEEEEEEECCCCCCCHHHHHHHCCCCC--EEE T ss_conf 899816984388887776437127763550344678989998---896899887316888310127786403777--689 Q ss_pred EEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEC Q ss_conf 98516663446899999999998640689987389984773456655324541157889999999999988294158852 Q Fun_Sc_NP_0140 107 ILLDWTLNDQKLWLNELSYAFNKIKQLNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSLFYIC 186 (312) Q Consensus 107 iLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGASLiYts 186 (312) +.-|-+. +..+ ..+.+|+..+++.+.....++|-.|+|-...+..+.. +-+..-.+.+|-.+|+..|.| T Consensus 78 lVfDit~--~~Sf-~~i~~W~~~i~~~~~~~~~ILVGNK~DL~~~~~~~~~-------~~~~~~~~~~a~~~~~~~~et- 146 (182) T cd04128 78 FMFDLTR--KSTL-NSIKEWYRQARGFNKTAIPILVGTKYDLFADLPPEEQ-------EEITKQARKYAKAMKAPLIFC- 146 (182) T ss_pred EEEECCC--HHHH-HHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHH-------HHHHHHHHHHHHHCCCCEEEE- T ss_conf 9986599--7899-9999999999862799608998327431001442456-------778899999999729959999- Q ss_pred CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCC Q ss_conf 56531355566778888753001247787752 Q Fun_Sc_NP_0140 187 EDHTEEKREEAQRLKYQELLKHFCEDRDMKDH 218 (312) Q Consensus 187 ~ts~~~~kn~~~~l~y~~L~~h~l~~~~~~~~ 218 (312) |+++..|-..++.. ++-.+++.+.+.+ T Consensus 147 --SAktg~nV~e~Fe~---l~~ki~~~~~~~~ 173 (182) T cd04128 147 --STSHSINVQKIFKI---VLAKAFDLPLTIP 173 (182) T ss_pred --ECCCCCCHHHHHHH---HHHHHHCCCCCCC T ss_conf --72479887899999---9999853788877 No 12 >cd00154 Rab Rab family. Rab GTPases form the largest family within the Ras superfamily. There are at least 60 Rab genes in the human genome, and a number of Rab GTPases are conserved from yeast to humans. Rab GTPases are small, monomeric proteins that function as molecular switches to regulate vesicle trafficking pathways. The different Rab GTPases are localized to the cytosolic face of specific intracellular membranes, where they regulate distinct steps in membrane traffic pathways. In the GTP-bound form, Rab GTPases recruit specific sets of effector proteins onto membranes. Through their effectors, Rab GTPases regulate vesicle formation, actin- and tubulin-dependent vesicle movement, and membrane fusion. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide di Probab=97.80 E-value=0.0081 Score=39.11 Aligned_columns=151 Identities=9% Q ss_pred EEEECCCCHHHHHHHHHHCCCC-CCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCCCCEEE Q ss_conf 8997598331799999851477-865566557502563356212133268899860785435887887718778782799 Q Fun_Sc_NP_0140 28 AIIYSPSSKTLHQFINICFPEG-SNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHSSKVRWL 106 (312) Q Consensus 28 ~lilg~~~~~~~~fi~~l~~~~-~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s~~~l~V 106 (312) ++++|..+.|||+|+.++.... .+.+.++.|.++....+.-+ ....++.+|=..| .+.+-.+.+-++.. -.-++ T Consensus 3 i~ivG~~~vGKTsli~~~~~~~f~~~~~~Ti~~~~~~k~i~~~-~~~~~~~i~Dt~g-~e~~~~~~~~~~~~---~d~~i 77 (159) T cd00154 3 IVLIGDSGVGKTSLLLRFVDGKFDENYKSTIGVDFKSKTIEID-GKTVKLQIWDTAG-QERFRSITPSYYRG---AHGAI 77 (159) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEEC-CEEEEEEEEECCC-CHHHHHHHHHHCCC---CCEEE T ss_conf 8998269966899999986382474446531003688899888-9599999986599-71456777875148---98699 Q ss_pred EEECCCCCCHHHHHHHHHHHHHHHHC-CCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEE Q ss_conf 98516663446899999999998640-68998738998477345665532454115788999999999998829415885 Q Fun_Sc_NP_0140 107 ILLDWTLNDQKLWLNELSYAFNKIKQ-LNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSLFYI 185 (312) Q Consensus 107 iLLDWs~~Dp~~Wlr~Lr~~~~~L~~-l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGASLiYt 185 (312) +..|-+. +..+ +.+..|+..+++ ...+.++++|++|+| |+.++-...++ .|.+|-++|+..+.+ T Consensus 78 iv~d~~~--~~Sf-~~i~~~~~~i~~~~~~~~piiivgnK~D----l~~~~~v~~~~--------~~~~~~~~~~~~~e~ 142 (159) T cd00154 78 LVYDITN--RESF-ENLDKWLKELKEYAPENIPIILVGNKID----LEDQRQVSTEE--------AQQFAKENGLLFFET 142 (159) T ss_pred EEEECCC--HHHH-HHHHHHHHHHHHHCCCCCEEEEEECCCC----HHHHCCCCHHH--------HHHHHHHCCCCEEEE T ss_conf 9986699--7899-9999999999982699978999841310----00102656889--------999999659969999 Q ss_pred CCCCCHHHHHHHHHHH Q ss_conf 2565313555667788 Q Fun_Sc_NP_0140 186 CEDHTEEKREEAQRLK 201 (312) Q Consensus 186 s~ts~~~~kn~~~~l~ 201 (312) |++...|-..++. T Consensus 143 ---Sa~~~~~i~~~F~ 155 (159) T cd00154 143 ---SAKTGENVEELFQ 155 (159) T ss_pred ---EECCCCCHHHHHH T ss_conf ---7047988789999 No 13 >1gwn_A RHO-related GTP-binding protein RHOE; inactive GTPase, signal transduction; HET: GTP; 2.1A {Mus musculus} SCOP: c.37.1.8 Probab=97.78 E-value=0.0032 Score=41.47 Aligned_columns=190 Identities=6% Q ss_pred HHHHHHHCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCE-EEEEEEEECCCH Q ss_conf 9988641011465536644389975983317999998514778655665575025633562121332-688998607854 Q Fun_Sc_NP_0140 8 DKLLSQNESTINSTETATITAIIYSPSSKTLHQFINICFPEGSNSILDTTLINYATIGWTNDLKENY-SVDVYTLIRNTD 86 (312) Q Consensus 8 s~iLse~~~~~~~k~~~~k~~lilg~~~~~~~~fi~~l~~~~~e~~~~~~~L~y~y~~v~~d~~d~~-R~~vy~L~~~~~ 86 (312) |.+...++...+.+....| ++++|..+.||++|+.++ -+.+.+.+..+-.....-..-...+.. .+.+|-..|... T Consensus 12 ~~~~~~~~~~~~~~~~~~K-I~liG~~~vGKTSli~~l--~~~~~~~~~~~ti~~~~~~~~~~~~~~~~i~i~Dt~G~~~ 88 (205) T 1gwn_A 12 SGLVPRGSHMDPNQNVKCK-IVVVGDSQCGKTALLHVF--AKDCFPENYVPTVFENYTASFEIDTQRIELSLWDTSGSPY 88 (205) T ss_dssp ---------------CEEE-EEEEESTTSSHHHHHHHH--HHSCCCSSCCCCSEEEEEEEEESSSSEEEEEEEEECCSGG T ss_pred CCCCCCCCCCCCCCCCEEE-EEEEECCCCCHHHHHHHH--HCCCCCCCCCCEEEEEEEEEEEECCEEEEEEEECCCCCCC T ss_conf 3557655578888873289-999816998789999998--6284476534302445899998634788654312422234 Q ss_pred HHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHH Q ss_conf 35887887718778782799985166634468999999999986406899873899847734566553245411578899 Q Fun_Sc_NP_0140 87 DALDLLKPFLQEHSSKVRWLILLDWTLNDQKLWLNELSYAFNKIKQLNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDF 166 (312) Q Consensus 87 ~~~~LLkp~L~~~s~~~l~ViLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDf 166 (312) ... ..-.--+.-..+++..|-+. +..+-..++.|...++....+.++++|..|+|....-......-....-.. T Consensus 89 ~~~----~~~~~~~~ad~~ilv~dv~~--~~Sf~~~~~~~~~~i~~~~~~~piiiVgNK~Dl~~~~~~~~~~~~~~~~~I 162 (205) T 1gwn_A 89 YDN----VRPLSYPDSDAVLICFDISR--PETLDSVLKKWKGEIQEFCPNTKMLLVGCKSDLRTDVSTLVELSNHRQTPV 162 (205) T ss_dssp GTT----TGGGGCTTCSEEEEEEETTC--HHHHHHHHHTHHHHHHHHCTTCEEEEEEECGGGGGCHHHHHHHHTTTCCCC T ss_pred CCC----CCCCCCCCCEEEEEEEECCC--HHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHCCCC T ss_conf 432----34100122011245763254--667778888889999863578727998605576532025788875212356 Q ss_pred HHHHHHHHHHHCCCEEEEECCCCCHHH-HHHHHHHHHHHHH Q ss_conf 999999999882941588525653135-5566778888753 Q Fun_Sc_NP_0140 167 ILQTLRSFCYFNDSSLFYICEDHTEEK-REEAQRLKYQELL 206 (312) Q Consensus 167 IqQ~LRtvcL~yGASLiYts~ts~~~~-kn~~~~l~y~~L~ 206 (312) -.+..+.+|-.+|+-.++-|.....++ .+....+...+.+ T Consensus 163 ~~~~~~~~a~~~~~~~~~E~SA~~~~n~i~evF~~~~~~ii 203 (205) T 1gwn_A 163 SYDQGANMAKQIGAATYIECSALQSENSVRDIFHVATLACV 203 (205) T ss_dssp CHHHHHHHHHHHTCSEEEECCTTTCHHHHHHHHHHHHHHHH T ss_pred CHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHH T ss_conf 88999999997189538997514787158999999999997 No 14 >cd00877 Ran Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases. Ran GTPase is involved in diverse biological functions, such as nuclear transport, spindle formation during mitosis, DNA replication, and cell division. Among the Ras superfamily, Ran is a unique small G protein. It does not have a lipid modification motif at the C-terminus to bind to the membrane, which is often observed within the Ras superfamily. Ran may therefore interact with a wide range of proteins in various intracellular locations. Like other GTPases, Ran exists in GTP- and GDP-bound conformations that interact differently with effectors. Conversion between these forms and the assembly or disassembly of effector complexes requires the interaction of regulator proteins. The intrinsic GTPase activity of Ran is very low, but it is greatly stimulated by a GTPase-activating protein (RanGAP1) located in the cytoplasm. By contrast, RCC1, a guanine nucleotide exchange factor that generates RanGTP, is Probab=97.77 E-value=0.0041 Score=40.86 Aligned_columns=157 Identities=9% Q ss_pred EEEECCCCHHHHHHHHHHCC-CCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCC-CCCEE Q ss_conf 89975983317999998514-77865566557502563356212133268899860785435887887718778-78279 Q Fun_Sc_NP_0140 28 AIIYSPSSKTLHQFINICFP-EGSNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHS-SKVRW 105 (312) Q Consensus 28 ~lilg~~~~~~~~fi~~l~~-~~~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s-~~~l~ 105 (312) ++++|+.+-|||+|+.+... .=.+.+.+..|.++....+..+ ..+.++.+|=..| .+.| ..+.+.- .+.-. T Consensus 3 IvliGd~~VGKTsli~r~~~~~F~~~y~~Tig~~~~~~~~~~~-~~~i~l~iwDtaG-~e~f-----~~l~~~y~~~a~~ 75 (166) T cd00877 3 LVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLDFHTN-RGKIRFNVWDTAG-QEKF-----GGLRDGYYIGGQC 75 (166) T ss_pred EEEEECCCCCHHHHHHHHHCCEECCCCCCEEEEEEEEEEEEEC-CCEEEEEEEECCC-CCCC-----CCCCCCCCCCCCE T ss_conf 8998269844899988876381166645346448889999987-9479999884578-5213-----5455120002675 Q ss_pred EEEE-CCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEE Q ss_conf 9985-166634468999999999986406899873899847734566553245411578899999999999882941588 Q Fun_Sc_NP_0140 106 LILL-DWTLNDQKLWLNELSYAFNKIKQLNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSLFY 184 (312) Q Consensus 106 ViLL-DWs~~Dp~~Wlr~Lr~~~~~L~~l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGASLiY 184 (312) +||+ |-+. +++.-. +..|.+.++......++++|..|+| |+.... .++..+|..+ +|+..|- T Consensus 76 ~ilvfDit~--~~Sf~~-i~~w~~~i~~~~~~ipivlVGNK~D----l~~~~~--~~~~~~~~~~--------~~~~~~E 138 (166) T cd00877 76 AIIMFDVTS--RVTYKN-VPNWHRDLVRVCGNIPIVLCGNKVD----IKDRKV--KAKQITFHRK--------KNLQYYE 138 (166) T ss_pred EEEEEECCC--HHHHHH-HHHHHHHHHHHCCCCCEEEEECCCC----CCCCCC--CHHHHHHHHH--------CCCCEEE T ss_conf 899986699--789898-9889999986459965899932677----320112--4899999995--------7994999 Q ss_pred ECCCCCHHHHHHHHHHHHHHHHHHCCCCCC Q ss_conf 525653135556677888875300124778 Q Fun_Sc_NP_0140 185 ICEDHTEEKREEAQRLKYQELLKHFCEDRD 214 (312) Q Consensus 185 ts~ts~~~~kn~~~~l~y~~L~~h~l~~~~ 214 (312) | |+++..|-...+.+ ++-.+.+.| T Consensus 139 t---SAk~g~NV~e~F~~---la~~il~~~ 162 (166) T cd00877 139 I---SAKSNYNFEKPFLW---LARKLLGNP 162 (166) T ss_pred E---ECCCCCCHHHHHHH---HHHHHHCCC T ss_conf 9---70489898899999---999985378 No 15 >2atx_A Small GTP binding protein TC10; GTPase, P-loop, alpha-beta; HET: GNP; 2.65A {Homo sapiens} SCOP: c.37.1.8 Probab=97.77 E-value=0.0022 Score=42.44 Aligned_columns=185 Identities=8% Q ss_pred CCCCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHH Q ss_conf 01146553664438997598331799999851477865566557502563356212133268899860785435887887 Q Fun_Sc_NP_0140 15 ESTINSTETATITAIIYSPSSKTLHQFINICFPEGSNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKP 94 (312) Q Consensus 15 ~~~~~~k~~~~k~~lilg~~~~~~~~fi~~l~~~~~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp 94 (312) ++++++-..-...++++|..+.||++|++++.......-............+..+ ....++.+|-..+..........+ T Consensus 8 ~~~~~~~~~~~iKi~iiG~~~vGKTsli~~~~~~~~~~~~~~t~~~~~~~~i~~~-~~~~~l~i~D~~g~~~~~~~~~~~ 86 (194) T 2atx_A 8 SSMAHGPGALMLKCVVVGDGAVGKTCLLMSYANDAFPEEYVPTVFDHYAVSVTVG-GKQYLLGLYDTAGQEDYDRLRPLS 86 (194) T ss_dssp -CCSSCCEEEEEEEEEEECTTSSHHHHHHHHHHSSCCCSCCCSSCCCEEEEEESS-SCEEEEEEECCCCSSSSTTTGGGG T ss_pred CCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEEC-CCEEEEEEECCCCCCCCHHHHHHH T ss_conf 4233586532788999817998789999998638437753541654344566534-944888761253210000123332 Q ss_pred HHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHH Q ss_conf 71877878279998516663446899999999998640689987389984773456655324541157889999999999 Q Fun_Sc_NP_0140 95 FLQEHSSKVRWLILLDWTLNDQKLWLNELSYAFNKIKQLNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSF 174 (312) Q Consensus 95 ~L~~~s~~~l~ViLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtv 174 (312) +-..+ .++++.|.+ |+...-.....|+..++....+-++++|..|+|-...-+..........-..-..-.+++ T Consensus 87 ~~~~~----~~ilV~d~~--~~~sf~~~~~~~~~~~~~~~~~~~iilVgnK~Dl~~~~~~~~~~~~~~~~~v~~~e~~~~ 160 (194) T 2atx_A 87 YPMTD----VFLICFSVV--NPASFQNVKEEWVPELKEYAPNVPFLLIGTQIDLRDDPKTLARLNDMKEKPICVEQGQKL 160 (194) T ss_dssp CTTCS----EEEEEEETT--CHHHHHHHHHTHHHHHHHHSTTCCEEEEEECTTSTTCHHHHHHHTTTTCCCCCHHHHHHH T ss_pred HCCCE----EEECCCCCC--HHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCHHHHHHH T ss_conf 02010----020000010--467888888876666653067853799862645554303677765520256378999999 Q ss_pred HHHCCCEEEEECCCCCHHHHHHHHHHHHHHHH Q ss_conf 98829415885256531355566778888753 Q Fun_Sc_NP_0140 175 CYFNDSSLFYICEDHTEEKREEAQRLKYQELL 206 (312) Q Consensus 175 cL~yGASLiYts~ts~~~~kn~~~~l~y~~L~ 206 (312) |-++|+..++-+.......-+++.-.....++ T Consensus 161 a~~~~~~~~~e~Sak~~~~I~~~f~~li~~il 192 (194) T 2atx_A 161 AKEIGACCYVECSALTQKGLKTVFDEAIIAIL 192 (194) T ss_dssp HHHHTCSCEEECCTTTCTTHHHHHHHHHHHHH T ss_pred HHHCCCCEEEEEEECCCCCHHHHHHHHHHHHH T ss_conf 99718922789750488788899999999970 No 16 >2j1l_A RHO-related GTP-binding protein RHOD; GTPase, membrane, prenylation, hydrolase, nucleotide-binding, methylation, lipoprotein, endosome dynamics; HET: GDP; 2.5A {Homo sapiens} Probab=97.75 E-value=0.002 Score=42.68 Aligned_columns=188 Identities=7% Q ss_pred CCCCCCCCCCCC---EEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHH Q ss_conf 011465536644---38997598331799999851477865566557502563356212133268899860785435887 Q Fun_Sc_NP_0140 15 ESTINSTETATI---TAIIYSPSSKTLHQFINICFPEGSNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDL 91 (312) Q Consensus 15 ~~~~~~k~~~~k---~~lilg~~~~~~~~fi~~l~~~~~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~L 91 (312) .+.+.+..|+.. .++++|+.+.||++|+.++..+.-.......+.......+.-+ ....++.+|-..+.... ..+ T Consensus 21 ~~~~~~~~~~~~r~iKI~iiG~~gvGKSSLi~~l~~~~~~~~~~~t~~~~~~~~~~~~-~~~~~~~iwD~~g~~~~-~~~ 98 (214) T 2j1l_A 21 QSMAGEEAPPGVRSVKVVLVGDGGCGKTSLLMVFADGAFPESYTPTVFERYMVNLQVK-GKPVHLHIWDTAGQDDY-DRL 98 (214) T ss_dssp -----------CCEEEEEEEECTTSSHHHHHHHHHC-------CCCCCEEEEEEEEET-TEEEEEEEEEC---------- T ss_pred HHCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEC-CEEEEEECCCCCCHHHH-HHH T ss_conf 2213224777776378998707997799999998637336764650135789998646-84787410356501121-001 Q ss_pred HHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHH Q ss_conf 88771877878279998516663446899999999998640689987389984773456655324541157889999999 Q Fun_Sc_NP_0140 92 LKPFLQEHSSKVRWLILLDWTLNDQKLWLNELSYAFNKIKQLNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTL 171 (312) Q Consensus 92 Lkp~L~~~s~~~l~ViLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~L 171 (312) -+.+++.-. .++++.|.+. +++.-.....|...++....+.++++|++|+|-...-+........-.-..-..-. T Consensus 99 ~~~~~~~~~---~iilV~d~~~--~~s~~~~~~~~~~~~~~~~~~~piilvgnK~Dl~~~~~~~~~~~~~~~~~i~~~~~ 173 (214) T 2j1l_A 99 RPLFYPDAS---VLLLCFDVTS--PNSFDNIFNRWYPEVNHFCKKVPIIVVGCKTDLRKDKSLVNKLRRNGLEPVTYHRG 173 (214) T ss_dssp ------CEE---EEEEEEETTC--HHHHHHHHHTHHHHHHHHCSSCCEEEEEECGGGGSCHHHHHHHHHTTCCCCCHHHH T ss_pred HHHHCCCCE---EEEEEECCCC--HHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCHHHH T ss_conf 022204404---5665311330--03344444678999986248863542113566311245666777630476737899 Q ss_pred HHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHC Q ss_conf 99998829415885256531355566778888753001 Q Fun_Sc_NP_0140 172 RSFCYFNDSSLFYICEDHTEEKREEAQRLKYQELLKHF 209 (312) Q Consensus 172 RtvcL~yGASLiYts~ts~~~~kn~~~~l~y~~L~~h~ 209 (312) +.++-++|.--++-+.....+.-+.+.--+....+..+ T Consensus 174 ~~~a~~~~~~~~~E~Sakt~~gV~~~f~~ii~~~l~~r 211 (214) T 2j1l_A 174 QEMARSVGAVAYLECSARLHDNVHAVFQEAAEVALSSR 211 (214) T ss_dssp HHHHHHTTCSEEEECBTTTTBSHHHHHHHHHHHHHHC- T ss_pred HHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHC T ss_conf 99999708931788740588678899999999999733 No 17 >1z0f_A RAB14, member RAS oncogene family; RAB GTPase, vesicular trafficking, protein transport; HET: GDP; 2.15A {Homo sapiens} SCOP: c.37.1.8 Probab=97.71 E-value=0.018 Score=37.05 Aligned_columns=169 Identities=8% Q ss_pred CCCCCCCC----CEEEEECCCCHHHHHHHHHHCC-CCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHH Q ss_conf 46553664----4389975983317999998514-778655665575025633562121332688998607854358878 Q Fun_Sc_NP_0140 18 INSTETAT----ITAIIYSPSSKTLHQFINICFP-EGSNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLL 92 (312) Q Consensus 18 ~~~k~~~~----k~~lilg~~~~~~~~fi~~l~~-~~~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LL 92 (312) .+++.|.+ -.++++|+.+.|||+|++++.. .-.+...+..+..+....+..+ ....++..|-..+........- T Consensus 4 ~~~~~~~~~~~~~Ki~iiG~~~vGKTSli~~~~~~~~~~~~~~t~~~~~~~~~~~~~-~~~~~~~i~d~~g~~~~~~~~~ 82 (179) T 1z0f_A 4 GSATAPYNYSYIFKYIIIGDMGVGKSCLLHQFTEKKFMADCPHTIGVEFGTRIIEVS-GQKIKLQIWDTAGQERFRAVTR 82 (179) T ss_dssp -------CCSEEEEEEEECSTTSSHHHHHHHHHHSCCCSSCTTSCCCCEEEEEEEET-TEEEEEEEEECTTGGGTCHHHH T ss_pred CCCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEEEC-CCEEEEEEECCCCCCCCCCCCH T ss_conf 666787675336899998079976899999986283277635315533578887521-8568655531677432232214 Q ss_pred HHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHH Q ss_conf 87718778782799985166634468999999999986406899873899847734566553245411578899999999 Q Fun_Sc_NP_0140 93 KPFLQEHSSKVRWLILLDWTLNDQKLWLNELSYAFNKIKQLNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLR 172 (312) Q Consensus 93 kp~L~~~s~~~l~ViLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LR 172 (312) ..+-+.+ .++++-|-+. +.+.-.....+-...+....+.++++|..|+|.-..-+-.. +-++ T Consensus 83 ~~~~~~~----~~i~v~d~~~--~~s~~~~~~~~~~~~~~~~~~~~iiivgnK~Dl~~~~~v~~------------~e~~ 144 (179) T 1z0f_A 83 SYYRGAA----GALMVYDITR--RSTYNHLSSWLTDARNLTNPNTVIILIGNKADLEAQRDVTY------------EEAK 144 (179) T ss_dssp HHHHTCS----EEEEEEETTC--HHHHHTHHHHHHHHHHHSCTTCEEEEEEECTTCGGGCCSCH------------HHHH T ss_pred HHHCCCC----EEEEEEECCC--CCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCH------------HHHH T ss_conf 4503887----7999976587--31011245677888863032322001001111131224388------------8999 Q ss_pred HHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCC Q ss_conf 999882941588525653135556677888875300124 Q Fun_Sc_NP_0140 173 SFCYFNDSSLFYICEDHTEEKREEAQRLKYQELLKHFCE 211 (312) Q Consensus 173 tvcL~yGASLiYts~ts~~~~kn~~~~l~y~~L~~h~l~ 211 (312) .+|=.+|+..+.+ |++...|-..++.. ++..++ T Consensus 145 ~~~~~~~~~~~e~---Sa~~g~gI~e~f~~---l~~~i~ 177 (179) T 1z0f_A 145 QFAEENGLLFLEA---SAKTGENVEDAFLE---AAKKIY 177 (179) T ss_dssp HHHHHTTCEEEEC---CTTTCTTHHHHHHH---HHHHHC T ss_pred HHHHHCCCEEEEE---ECCCCCCHHHHHHH---HHHHHH T ss_conf 9999649839999---62689788899999---999996 No 18 >2oil_A CATX-8, RAS-related protein RAB-25; G-protein, GDP, structural genomics, structural genomics consortium, SGC; HET: GDP; 2.30A {Homo sapiens} Probab=97.71 E-value=0.013 Score=37.94 Aligned_columns=176 Identities=9% Q ss_pred CCCCCCCCCCE-------EEEECCCCHHHHHHHHHHCCCC-CCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHH Q ss_conf 14655366443-------8997598331799999851477-865566557502563356212133268899860785435 Q Fun_Sc_NP_0140 17 TINSTETATIT-------AIIYSPSSKTLHQFINICFPEG-SNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDA 88 (312) Q Consensus 17 ~~~~k~~~~k~-------~lilg~~~~~~~~fi~~l~~~~-~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~ 88 (312) +|+|-.|++.+ ++++|+.+.||++|++++.... .+.+.+..+..+....+.-+ ....++..|-..+.-... T Consensus 10 ~~~~~~~r~~~~~d~~~KI~iiG~~~vGKSSli~~l~~~~~~~~~~~t~~~~~~~~~~~~~-~~~~~l~i~d~~g~~~~~ 88 (193) T 2oil_A 10 HSSGLVPRGSEDYNFVFKVVLIGESGVGKTNLLSRFTRNEFSHDSRTTIGVEFSTRTVMLG-TAAVKAQIWDTAGLERYR 88 (193) T ss_dssp ----------CCCSEEEEEEEESSTTSSHHHHHHHHHHSCCCSSCCCCSSEEEEEEEEEET-TEEEEEEEEEESCCCTTC T ss_pred CCCCCCCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEEC-CEEEEEEEECCCCCHHHC T ss_conf 4567788998675457899998079987999999986581157635614666777788765-656666761466700110 Q ss_pred HHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHH Q ss_conf 88788771877878279998516663446899999999998640689987389984773456655324541157889999 Q Fun_Sc_NP_0140 89 LDLLKPFLQEHSSKVRWLILLDWTLNDQKLWLNELSYAFNKIKQLNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFIL 168 (312) Q Consensus 89 ~~LLkp~L~~~s~~~l~ViLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIq 168 (312) .-.-..+-.++ -+++..|-+. +...-..-+.+....+....+-++++|+.|+| |+++.-... T Consensus 89 ~~~~~~~~~~~----~~i~v~d~~~--~~s~~~~~~~~~~i~~~~~~~~piilv~nK~D----l~~~~~v~~-------- 150 (193) T 2oil_A 89 AITSAYYRGAV----GALLVFDLTK--HQTYAVVERWLKELYDHAEATIVVMLVGNKSD----LSQAREVPT-------- 150 (193) T ss_dssp TTHHHHHTTCC----EEEEEEETTC--HHHHHTHHHHHHHHHTTSCTTCEEEEEEECGG----GGGGCCSCH-------- T ss_pred CCHHCCCCCCE----EEEEEEEECC--CCHHHHHHHHHHHHHHCCCCCEEEEEEECCHH----HHHHHCCHH-------- T ss_conf 00002256752----7999975034--00000111100122100356134433213202----233311136-------- Q ss_pred HHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCC Q ss_conf 9999999882941588525653135556677888875300124778775 Q Fun_Sc_NP_0140 169 QTLRSFCYFNDSSLFYICEDHTEEKREEAQRLKYQELLKHFCEDRDMKD 217 (312) Q Consensus 169 Q~LRtvcL~yGASLiYts~ts~~~~kn~~~~l~y~~L~~h~l~~~~~~~ 217 (312) +.++.++-.++...+.+ |++...+...++.. ++..++.+..++ T Consensus 151 ~~~~~~~~~~~~~~~~~---Sak~~~~I~elf~~---i~~~i~~k~~k~ 193 (193) T 2oil_A 151 EEARMFAENNGLLFLET---SALDSTNVELAFET---VLKEIFAKVSKQ 193 (193) T ss_dssp HHHHHHHHHTTCEEEEE---CTTTCTTHHHHHHH---HHHHHHHHHHTC T ss_pred HHHHHHHHHCCCEEEEE---ECCCCCCHHHHHHH---HHHHHHHHHHCC T ss_conf 77789998659729998---62689788899999---999999864049 No 19 >d1d5ca_ c.37.1.8 (A:) Rab6 {Malaria parasite (Plasmodium falciparum)} Probab=97.66 E-value=0.027 Score=36.04 Aligned_columns=152 Identities=9% Q ss_pred EEEECCCCHHHHHHHHHHCC-CCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCCCCEEE Q ss_conf 89975983317999998514-77865566557502563356212133268899860785435887887718778782799 Q Fun_Sc_NP_0140 28 AIIYSPSSKTLHQFINICFP-EGSNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHSSKVRWL 106 (312) Q Consensus 28 ~lilg~~~~~~~~fi~~l~~-~~~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s~~~l~V 106 (312) ++++|..+.||++|++++.. .-.+.+.++.+.++....+... ....++.+|-..+.-.........+-..+ -++ T Consensus 4 i~i~G~~~vGKSsLi~~l~~~~~~~~~~~t~~~~~~~~~~~~~-~~~~~~~~~d~~g~~~~~~~~~~~~~~~d----~~i 78 (162) T d1d5ca_ 4 LVFLGEQAVGKTSIITRFMYDTFDNNYQSTIGIDFLSKTLYLD-EGPVRLQLWDTAGQERFRSLIPSYIRDSA----AAI 78 (162) T ss_dssp EEEECSTTSSHHHHHHHHHHSCCCTTCCCCCCCEEEEEEEEET-TEEEEEEEEECCCSGGGGGGHHHHHTTCS----EEE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEEEC-CEEEEEEEECCCCCCHHHHHHHHHHCCCC----EEE T ss_conf 8998179987999999986480156613315546777897308-81699986237652033456677632683----899 Q ss_pred EEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEC Q ss_conf 98516663446899999999998640689987389984773456655324541157889999999999988294158852 Q Fun_Sc_NP_0140 107 ILLDWTLNDQKLWLNELSYAFNKIKQLNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSLFYIC 186 (312) Q Consensus 107 iLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGASLiYts 186 (312) ++.|-+ |++.+-..-...-...+.....-+++||+.|+| |+.+.....++...|.+ .+|+..+.+ T Consensus 79 ~v~d~~--~~~s~~~~~~~l~~i~~~~~~~~piilvgnK~D----l~~~~~v~~~~~~~~~~--------~~~~~~~~~- 143 (162) T d1d5ca_ 79 VVYDIT--NRQSFENTTKWIQDILNERGKDVIIALVGNKTD----LGDLRKVTYEEGMQKAQ--------EYNTMFHET- 143 (162) T ss_dssp EEEETT--CHHHHHTHHHHHHHHHHHHTTSSEEEEEEECGG----GGGGCCSCHHHHHHHHH--------HTTCEEEEC- T ss_pred EEEECC--CCCCHHHHHHHHHHHHHHCCCCEEEEEEEECCC----CCCCCCCCHHHHHHHHH--------HCCCEEEEE- T ss_conf 997446--667778999999999751248657899752146----53224548899999999--------649929999- Q ss_pred CCCCHHHHHHHHHHH Q ss_conf 565313555667788 Q Fun_Sc_NP_0140 187 EDHTEEKREEAQRLK 201 (312) Q Consensus 187 ~ts~~~~kn~~~~l~ 201 (312) |++...+-..++. T Consensus 144 --Sa~~g~gv~~lf~ 156 (162) T d1d5ca_ 144 --SAKAGHNIKVLFK 156 (162) T ss_dssp --BTTTTBSCHHHHH T ss_pred --ECCCCCCHHHHHH T ss_conf --7268968789999 No 20 >2rex_B RHO-related GTP-binding protein RHO6; complex, structural genomics consortium, SGC, GTPase, GNP, plexin, effector domain, alternative splicing; HET: GNP; 2.30A {Homo sapiens} Probab=97.65 E-value=0.0025 Score=42.15 Aligned_columns=184 Identities=7% Q ss_pred EEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCE-EEEEEEEECCCHHHHHHHHHHHCCCCCCCEEE Q ss_conf 89975983317999998514778655665575025633562121332-68899860785435887887718778782799 Q Fun_Sc_NP_0140 28 AIIYSPSSKTLHQFINICFPEGSNSILDTTLINYATIGWTNDLKENY-SVDVYTLIRNTDDALDLLKPFLQEHSSKVRWL 106 (312) Q Consensus 28 ~lilg~~~~~~~~fi~~l~~~~~e~~~~~~~L~y~y~~v~~d~~d~~-R~~vy~L~~~~~~~~~LLkp~L~~~s~~~l~V 106 (312) ++++|..+.|||+|+.++ -+.+......+-..-.....-...+.. ++.+|-..|...... ..-..-+.-.-++ T Consensus 13 i~vvG~~~vGKTsli~~~--~~~~~~~~~~~t~~~~~~~~~~~~~~~~~l~iwD~~g~~~~~~----~~~~~~~~~~~~i 86 (197) T 2rex_B 13 LVLVGDVQCGKTAMLQVL--AKDCYPETYVPTVFENYTACLETEEQRVELSLWDTSGSPYYDN----VRPLCYSDSDAVL 86 (197) T ss_dssp EEEECSTTSSHHHHHHHH--HHSCCCCSCCCCSEEEEEEEE---CCCEEEEEEEECCSGGGTT----TGGGGGTTCSEEE T ss_pred EEEEECCCCCHHHHHHHH--HCCCCCCCCCCEEEEEEEEEEEEECEEEEEEEECCCCCCCCCC----CCCCCCCCEEEEE T ss_conf 999816998789999998--6175576534327775677523202145776411312112221----2300010112357 Q ss_pred EEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEC Q ss_conf 98516663446899999999998640689987389984773456655324541157889999999999988294158852 Q Fun_Sc_NP_0140 107 ILLDWTLNDQKLWLNELSYAFNKIKQLNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSLFYIC 186 (312) Q Consensus 107 iLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGASLiYts 186 (312) +..|-+. +...-..+..|...++....+.++++|++|+|-..............+--.-.+-.+.+|-++|+..++-+ T Consensus 87 ~v~d~~~--~~S~~~~~~~~~~~~~~~~~~~~iilVgnK~DL~~~~~~~~~~~~~~~~~is~~e~~~~a~~~~~~~y~E~ 164 (197) T 2rex_B 87 LCFDISR--PETVDSALKKWRTEILDYCPSTRVLLIGCKTDLRTDLSTLMELSHQKQAPISYEQGCAIAKQLGAEIYLEG 164 (197) T ss_dssp EEEETTC--TTTC--CHHHHHHHHHHHCTTSEEEEEEECGGGGGCHHHHHHHHHTTCCCCCHHHHHHHHHHTTCSCEEEC T ss_pred EEECCCH--HHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEE T ss_conf 6304560--67899999887776776179947999504568632113556655542046788999999996599589987 Q ss_pred CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCC Q ss_conf 565313555667788887530012477877522 Q Fun_Sc_NP_0140 187 EDHTEEKREEAQRLKYQELLKHFCEDRDMKDHI 219 (312) Q Consensus 187 ~ts~~~~kn~~~~l~y~~L~~h~l~~~~~~~~a 219 (312) ...+.+.--....-.-..+++++..-.|.++|+ T Consensus 165 Sakt~~~~v~~~f~~~~~~~~~~~~~~p~~sp~ 197 (197) T 2rex_B 165 SAFTSEKSIHSIFRTASMLCLNKPSPLPQKSPV 197 (197) T ss_dssp BTTTBHHHHHHHHHHHHHHHC------------ T ss_pred EECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC T ss_conf 523466127999999999996287888867789 No 21 >1x3s_A RAS-related protein RAB-18; GTPase, GNP, structural genomics, NPPSFA, national project on protein structural and functional analyses; HET: GNP; 1.32A {Homo sapiens} SCOP: c.37.1.8 Probab=97.64 E-value=0.016 Score=37.39 Aligned_columns=177 Identities=8% Q ss_pred CCCCCCCCCCCCEEEEECCCCHHHHHHHHHHCC-CCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHH Q ss_conf 011465536644389975983317999998514-7786556655750256335621213326889986078543588788 Q Fun_Sc_NP_0140 15 ESTINSTETATITAIIYSPSSKTLHQFINICFP-EGSNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLK 93 (312) Q Consensus 15 ~~~~~~k~~~~k~~lilg~~~~~~~~fi~~l~~-~~~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLk 93 (312) ++-.+-...++..++++|....||++|++++.. .-...+.+..+..+.+..+.-+ ....++..|-..+-.....-.-. T Consensus 5 ~~~m~~~~~~~~KI~viG~~~vGKTsLi~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~i~D~~~~~~~~~~~~~ 83 (195) T 1x3s_A 5 SSGMDEDVLTTLKILIIGESGVGKSSLLLRFTDDTFDPELAATIGVDFKVKTISVD-GNKAKLAIWDTAGQERFRTLTPS 83 (195) T ss_dssp ----CTTEEEEEEEEEECSTTSSHHHHHHHHHHSCCCTTCCCCCSEEEEEEEEEET-TEEEEEEEEEECSSGGGCCSHHH T ss_pred CCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEEEC-CEEEEEEEECCCCHHHHHHHHHH T ss_conf 76654236451568998069987999999986581365533202211257888887-87889885003220022334377 Q ss_pred HHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCC--CEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHH Q ss_conf 77187787827999851666344689999999999864068998--7389984773456655324541157889999999 Q Fun_Sc_NP_0140 94 PFLQEHSSKVRWLILLDWTLNDQKLWLNELSYAFNKIKQLNDDN--EFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTL 171 (312) Q Consensus 94 p~L~~~s~~~l~ViLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~Dt--~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~L 171 (312) ++-+.+- ++++.|-+. +..+-. +..|+..+++..... +++||+.|+| |+.....+.+ + T Consensus 84 ~~~~~~~----~i~v~d~~~--~~S~~~-~~~~~~~i~~~~~~~~~piiiv~nK~D----l~~~~v~~~~---------~ 143 (195) T 1x3s_A 84 YYRGAQG----VILVYDVTR--RDTFVK-LDNWLNELETYCTRNDIVNMLVGNKID----KENREVDRNE---------G 143 (195) T ss_dssp HHTTCCE----EEEEEETTC--HHHHHT-HHHHHHHHTTCCSCSCCEEEEEEECTT----SSSCCSCHHH---------H T ss_pred HHCCCCC----EEEEEECCC--CCCHHH-HHHHHHHHHHHCCCCCCEEEEECCCCC----HHHCCCHHHH---------H T ss_conf 7225881----289972367--410112-478887665410124530677426520----0110101789---------9 Q ss_pred HHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCC Q ss_conf 99998829415885256531355566778888753001247787752 Q Fun_Sc_NP_0140 172 RSFCYFNDSSLFYICEDHTEEKREEAQRLKYQELLKHFCEDRDMKDH 218 (312) Q Consensus 172 RtvcL~yGASLiYts~ts~~~~kn~~~~l~y~~L~~h~l~~~~~~~~ 218 (312) +.++-++|+..+.+ |++...+....+.. ++..+...+...+ T Consensus 144 ~~~~~~~~~~~~e~---Sa~~~~gi~~~f~~---i~~~i~~~~~~~~ 184 (195) T 1x3s_A 144 LKFARKHSMLFIEA---SAKTCDGVQCAFEE---LVEKIIQTPGLWE 184 (195) T ss_dssp HHHHHHTTCEEEEC---CTTTCTTHHHHHHH---HHHHHHTSGGGTC T ss_pred HHHHHHCCCEEEEE---ECCCCCCHHHHHHH---HHHHHHHCCCCCC T ss_conf 99999629879998---51678788899999---9999974457676 No 22 >d3raba_ c.37.1.8 (A:) Rab3a {Rat (Rattus norvegicus)} SCOP: d1zbda_ Probab=97.61 E-value=0.025 Score=36.20 Aligned_columns=159 Identities=11% Q ss_pred EEEECCCCHHHHHHHHHHCC-CCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCC-CCCEE Q ss_conf 89975983317999998514-77865566557502563356212133268899860785435887887718778-78279 Q Fun_Sc_NP_0140 28 AIIYSPSSKTLHQFINICFP-EGSNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHS-SKVRW 105 (312) Q Consensus 28 ~lilg~~~~~~~~fi~~l~~-~~~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s-~~~l~ 105 (312) ++++|..+.||++|++++.. .-.+.+....+.++.+..+..+ ....++.+|-..|..... +.....- .-..+ T Consensus 8 i~iiG~~~vGKTsLi~~~~~~~~~~~~~~~~~~~~~~~~i~~~-~~~~~~~i~d~~g~~~~~-----~~~~~~~~~~d~~ 81 (169) T d3raba_ 8 ILIIGNSSVGKTSFLFRYADDSFTPAFVSTVGIDFKVKTIYRN-DKRIKLQIWDTAGQERYR-----TITTAYYRGAMGF 81 (169) T ss_dssp EEEECSTTSSHHHHHHHHHHSCCCSSCCCCCSEEEEEEEEEET-TEEEEEEEEEECCSGGGH-----HHHHTTTTTCCEE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEEEC-CEEEEEEEEECCCCCHHH-----HHHHHHCCCCCEE T ss_conf 9998369987999999986580154402201103578999998-868999985157731122-----3212110134578 Q ss_pred EEEECCCCCCHHHHHHHHHHHHHHHHCCCCC-CCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEE Q ss_conf 9985166634468999999999986406899-873899847734566553245411578899999999999882941588 Q Fun_Sc_NP_0140 106 LILLDWTLNDQKLWLNELSYAFNKIKQLNDD-NEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSLFY 184 (312) Q Consensus 106 ViLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~D-t~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGASLiY 184 (312) ++..|-+. +..+ ..+..|...+++.... .+++||+.|+| |.++.-...++ .+.++-++|...+. T Consensus 82 i~v~d~~~--~~s~-~~~~~~~~~i~~~~~~~~pivvv~nK~D----l~~~~~v~~~~--------~~~~~~~~~~~~~~ 146 (169) T d3raba_ 82 ILMYDITN--EESF-NAVQDWSTQIKTYSWDNAQVLLVGNKCD----MEDERVVSSER--------GRQLADHLGFEFFE 146 (169) T ss_dssp EEEEETTC--HHHH-HTHHHHHHHHHHHCCSCCEEEEEEECTT----CGGGCCSCHHH--------HHHHHHHHTCEEEE T ss_pred EEEEECCC--CCHH-HHHHHHHHHHHHHHCCCCCEEHHHHCCC----CCCCCCCCHHH--------HHHHHHHCCCEEEE T ss_conf 99862255--4205-6688899998765306830000000123----21112578889--------99999955983999 Q ss_pred ECCCCCHHHHHHHHHHHHHHHHHHCCCCC Q ss_conf 52565313555667788887530012477 Q Fun_Sc_NP_0140 185 ICEDHTEEKREEAQRLKYQELLKHFCEDR 213 (312) Q Consensus 185 ts~ts~~~~kn~~~~l~y~~L~~h~l~~~ 213 (312) + |+....|-..++.. ++..+..+ T Consensus 147 ~---Sa~~g~~i~e~f~~---li~~i~~~ 169 (169) T d3raba_ 147 A---SAKDNINVKQTFER---LVDVICEK 169 (169) T ss_dssp C---BTTTTBSHHHHHHH---HHHHHHTC T ss_pred E---ECCCCCCHHHHHHH---HHHHHHHC T ss_conf 8---72689888899999---99999609 No 23 >e1z2aa_ c.37.1.8 (A:) Rab23 {Mouse (Mus musculus) [TaxID:10090]} Probab=97.60 E-value=0.0073 Score=39.36 Aligned_columns=153 Identities=7% Q ss_pred EEEEECCCCHHHHHHHHHHCCCC-CCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCCCCEE Q ss_conf 38997598331799999851477-86556655750256335621213326889986078543588788771877878279 Q Fun_Sc_NP_0140 27 TAIIYSPSSKTLHQFINICFPEG-SNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHSSKVRW 105 (312) Q Consensus 27 ~~lilg~~~~~~~~fi~~l~~~~-~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s~~~l~ 105 (312) .++++|..+.||++|++++.... .+.+.++.+.+|....+.-+ ....++..|-..+........-..+-..+ .+ T Consensus 4 kI~ivG~~~vGKSsli~~l~~~~~~~~~~~t~~~~~~~~~~~~~-~~~~~l~i~d~~~~~~~~~~~~~~~~~~d----~~ 78 (164) T e1z2aa_ 4 KMVVVGNGAVGKSSMIQRYCKGIFTKDYKKTIGVDFLERQIQVN-DEDVRLMLWDTAGQEEFDAITKAYYRGAQ----AC 78 (164) T ss_pred EEEEECCCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEEEC-CEEEEEEECCCCCCCHHHHHHHHHCCCCC----EE T ss_conf 89998289988999999986480167623404533588999973-28887410146422024577886405875----79 Q ss_pred EEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEE Q ss_conf 99851666344689999999999864068998738998477345665532454115788999999999998829415885 Q Fun_Sc_NP_0140 106 LILLDWTLNDQKLWLNELSYAFNKIKQLNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSLFYI 185 (312) Q Consensus 106 ViLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGASLiYt 185 (312) +++.|-+. +...-. +.+|+..++.-..+.+++||++|+|....-+-.. ..++.++-.+|+..+.+ T Consensus 79 i~v~d~~~--~~s~~~-~~~~~~~i~~~~~~~piiiv~nK~Dl~~~~~i~~------------~~~~~~~~~~~~~~~e~ 143 (164) T e1z2aa_ 79 VLVFSTTD--RESFEA-ISSWREKVVAEVGDIPTALVQNKIDLLDDSCIKN------------EEAEGLAKRLKLRFYRT 143 (164) T ss_pred EEEEECCC--CCCHHH-HHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCH------------HHHHHHHHHCCCEEEEE T ss_conf 99974045--542467-8888887431002300234442002111236798------------99999999659909999 Q ss_pred CCCCCHHHHHHHHHHHH Q ss_conf 25653135556677888 Q Fun_Sc_NP_0140 186 CEDHTEEKREEAQRLKY 202 (312) Q Consensus 186 s~ts~~~~kn~~~~l~y 202 (312) |++...+-..++.. T Consensus 144 ---Sa~~~~~i~~~f~~ 157 (164) T e1z2aa_ 144 ---SVKEDLNVSEVFKY 157 (164) T ss_pred ---ECCCCCCHHHHHHH T ss_conf ---71589888899999 No 24 >d1oiva_ c.37.1.8 (A:) Rab11a {Human (Homo sapiens)} Probab=97.56 E-value=0.025 Score=36.16 Aligned_columns=159 Identities=9% Q ss_pred EEEECCCCHHHHHHHHHHCC-CCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCCCCEEE Q ss_conf 89975983317999998514-77865566557502563356212133268899860785435887887718778782799 Q Fun_Sc_NP_0140 28 AIIYSPSSKTLHQFINICFP-EGSNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHSSKVRWL 106 (312) Q Consensus 28 ~lilg~~~~~~~~fi~~l~~-~~~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s~~~l~V 106 (312) ++++|....||++|++++.. .-.+...+..+..+....+.-+ ....++..|-..|............-..+. ++ T Consensus 9 i~ivG~~~vGKSSLi~~l~~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~i~D~~g~~~~~~~~~~~~~~~d~----~i 83 (168) T d1oiva_ 9 VVLIGDSGVGKSNLLSRFTRNEFNLESKSTIGVEFATRSIQVD-GKTIKAQIWDTAGQERYRAITSAYYRGAVG----AL 83 (168) T ss_dssp EEEESSTTSSHHHHHHHHHHSCCCSSCCCCSSEEEEEEEEEET-TEEEEEEEEEECSCCCCHHHHHHHHTTEEE----EE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEEEC-CEEEEEEEECCCCCCHHHHHHHHHHCCCCE----EE T ss_conf 9998369987999999986580343655326533422789988-948999985067830123555776227878----99 Q ss_pred EEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEC Q ss_conf 98516663446899999999998640689987389984773456655324541157889999999999988294158852 Q Fun_Sc_NP_0140 107 ILLDWTLNDQKLWLNELSYAFNKIKQLNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSLFYIC 186 (312) Q Consensus 107 iLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGASLiYts 186 (312) ++.|=+..+....+..+...+...+. .+.++++|++|+| |+++.-...++ .|.+|-.+|+..+-+ T Consensus 84 ~v~d~~~~~s~~~i~~~~~~i~~~~~--~~~piiivgnK~D----l~~~~~v~~~~--------~~~~~~~~~~~~~e~- 148 (168) T d1oiva_ 84 LVYDIAKHLTYENVERWLKELRDHAD--SNIVIMLVGNKSD----LRHLRAVPTDE--------ARAFAEKNGLSFIET- 148 (168) T ss_dssp EEEETTCHHHHHTHHHHHHHHHHHSC--TTCEEEEEEECTT----CGGGCCSCHHH--------HHHHHHHHTCEEEEC- T ss_pred EEEEECCCCHHHHHHHHHHHHHHHCC--CCEEEEEEEECCC----HHHCCCCCHHH--------HHHHHHHCCCCEEEE- T ss_conf 99984263016889999999986148--9538996110001----22203779899--------999999639938999- Q ss_pred CCCCHHHHHHHHHHHHHHHHHHCCC Q ss_conf 5653135556677888875300124 Q Fun_Sc_NP_0140 187 EDHTEEKREEAQRLKYQELLKHFCE 211 (312) Q Consensus 187 ~ts~~~~kn~~~~l~y~~L~~h~l~ 211 (312) |+++..|-..++.. ++..+| T Consensus 149 --Sak~g~~i~e~f~~---ii~~i~ 168 (168) T d1oiva_ 149 --SALDSTNVEAAFQT---ILTEIY 168 (168) T ss_dssp --CTTTCTTHHHHHHH---HHHHHC T ss_pred --ECCCCCCHHHHHHH---HHHHHC T ss_conf --71689787899999---999709 No 25 >d1r2qa_ c.37.1.8 (A:) Rab5a {Human (Homo sapiens)} SCOP: d1n6oa_ d1tu4a_ d1n6la_ d1tu4d_ d1n6ka_ d1n6ha_ d1tu3c_ d1tu3b_ d1n6na_ d1n6ra_ d1tu4b_ d1n6pa_ d1tu3d_ u1z0da1 d1huqa_ u1z07a1 Probab=97.56 E-value=0.1 Score=32.58 Aligned_columns=168 Identities=8% Q ss_pred CCCCCCCEEEEECCCCHHHHHHHHHHCC-CCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCC Q ss_conf 5536644389975983317999998514-778655665575025633562121332688998607854358878877187 Q Fun_Sc_NP_0140 20 STETATITAIIYSPSSKTLHQFINICFP-EGSNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQE 98 (312) Q Consensus 20 ~k~~~~k~~lilg~~~~~~~~fi~~l~~-~~~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~ 98 (312) |-..+.-.++++|+.+.||++|++++.. .-.+.+.+..+.++....+..+ ....++.+|-..|.-.. ..+....+.. T Consensus 1 ~~~~~~~Ki~ivG~~~vGKTsli~~~~~~~~~~~~~~t~~~~~~~~~~~~~-~~~~~~~i~D~~g~~~~-~~~~~~~~~~ 78 (170) T d1r2qa_ 1 GNKICQFKLVLLGESAVGKSSLVLRFVKGQFHEFQESTIGAAFLTQTVCLD-DTTVKFEIWDTAGQERY-HSLAPMYYRG 78 (170) T ss_dssp CCEEEEEEEEEECSTTSSHHHHHHHHHHSCCCTTCCCCSSEEEEEEEEEET-TEEEEEEEEEECCSGGG-GGGHHHHHTT T ss_pred CCCCCEEEEEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEEEC-CEEEEEEEECCCCCHHH-HHHHHHHCCC T ss_conf 987522689998279977999999986481255635303567777656556-90799987427773034-4541210268 Q ss_pred CCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHC Q ss_conf 78782799985166634468999999999986406899873899847734566553245411578899999999999882 Q Fun_Sc_NP_0140 99 HSSKVRWLILLDWTLNDQKLWLNELSYAFNKIKQLNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFN 178 (312) Q Consensus 99 ~s~~~l~ViLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~y 178 (312) - .-+++..|-+. +...-+.-+.+-...+....+-++++|..|+| |+.+.....++ ++.++-.+ T Consensus 79 ~---~~~i~v~d~~~--~~s~~~~~~~~~~~~~~~~~~~piilv~nK~D----l~~~~~i~~~~--------~~~~~~~~ 141 (170) T d1r2qa_ 79 A---QAAIVVYDITN--EESFARAKNWVKELQRQASPNIVIALSGNKAD----LANKRAVDFQE--------AQSYADDN 141 (170) T ss_dssp C---SEEEEEEETTC--HHHHHHHHHHHHHHHHHSCTTCEEEEEEECGG----GGGGCCSCHHH--------HHHHHHHT T ss_pred C---CEEEEEEECCC--HHHHHHHHHHHHHHHHHHHCCCCEEEEECCHH----HHHHCCCCHHH--------HHHHHHHC T ss_conf 8---67999830652--03588898889999886405861244303211----01003658789--------99999855 Q ss_pred CCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCC Q ss_conf 9415885256531355566778888753001247 Q Fun_Sc_NP_0140 179 DSSLFYICEDHTEEKREEAQRLKYQELLKHFCED 212 (312) Q Consensus 179 GASLiYts~ts~~~~kn~~~~l~y~~L~~h~l~~ 212 (312) ++..+.+ |.+...+-..++.. ++..++. T Consensus 142 ~~~~~e~---Sak~g~gi~elf~~---i~~~l~~ 169 (170) T d1r2qa_ 142 SLLFMET---SAKTSMNVNEIFMA---IAKKLPK 169 (170) T ss_dssp TCEEEEC---CTTTCTTHHHHHHH---HHHTSCC T ss_pred CCEEEEE---ECCCCCCHHHHHHH---HHHHHCC T ss_conf 9839998---61689788899999---9998414 No 26 >cd04122 Rab14 Rab14 subfamily. Rab14 GTPases are localized to biosynthetic compartments, including the rough ER, the Golgi complex, and the trans-Golgi network, and to endosomal compartments, including early endosomal vacuoles and associated vesicles. Rab14 is believed to function in both the biosynthetic and recycling pathways between the Golgi and endosomal compartments. Rab14 has also been identified on GLUT4 vesicles, and has been suggested to help regulate GLUT4 translocation. In addition, Rab14 is believed to play a role in the regulation of phagocytosis. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GT Probab=97.50 E-value=0.022 Score=36.53 Aligned_columns=157 Identities=9% Q ss_pred EEEECCCCHHHHHHHHHHCC-CCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCC-CCCEE Q ss_conf 89975983317999998514-77865566557502563356212133268899860785435887887718778-78279 Q Fun_Sc_NP_0140 28 AIIYSPSSKTLHQFINICFP-EGSNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHS-SKVRW 105 (312) Q Consensus 28 ~lilg~~~~~~~~fi~~l~~-~~~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s-~~~l~ 105 (312) ++++|+.+-|||+|+.+... .=.+.+....+.+|....+ .-++.++.+-+.+.+.-+.. ..+.+.- .+.-. T Consensus 5 ivviGd~~VGKTsli~r~~~~~f~~~~~~Ti~~~~~~k~i---~~~~~~v~l~i~Dt~G~e~~----~~~~~~~~~~a~~ 77 (166) T cd04122 5 YIIIGDMGVGKSCLLHQFTEKKFMADCPHTIGVEFGTRII---EVNGQKIKLQIWDTAGQERF----RAVTRSYYRGAAG 77 (166) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCEEEEEEE---EECCEEEEEEEEECCCCHHH----HHHHHHHCCCCCE T ss_conf 9998269955899998876384364456210221467888---52890899998635886023----4553864269875 Q ss_pred EEEECCCCCCHHHHHHHHHHHHHHHHCC-CCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEE Q ss_conf 9985166634468999999999986406-899873899847734566553245411578899999999999882941588 Q Fun_Sc_NP_0140 106 LILLDWTLNDQKLWLNELSYAFNKIKQL-NDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSLFY 184 (312) Q Consensus 106 ViLLDWs~~Dp~~Wlr~Lr~~~~~L~~l-~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGASLiY 184 (312) +|++ .+..++... ..+.+|+...++. +.+.++++|..|+| |+.++ .-..++ .+.+|-++|+..+- T Consensus 78 ~ilv-ydit~~~Sf-~~i~~w~~~~~~~~~~~~~iilVGNK~D----L~~~r-~v~~~e-------~~~~a~~~~~~~~E 143 (166) T cd04122 78 ALMV-YDITRRSTY-NHLSSWLTDARNLTNPNTVIFLIGNKAD----LEAQR-DVTYEE-------AKQFADENGLLFLE 143 (166) T ss_pred EEEE-EECCCHHHH-HHHHHHHHHHHHCCCCCCEEEEECCHHH----HHHHC-CCCHHH-------HHHHHHHCCCEEEE T ss_conf 9998-207998789-9999999999740489957999637254----44303-541789-------99999964991999 Q ss_pred ECCCCCHHHHHHHHHHHHHHHHHHCCC Q ss_conf 525653135556677888875300124 Q Fun_Sc_NP_0140 185 ICEDHTEEKREEAQRLKYQELLKHFCE 211 (312) Q Consensus 185 ts~ts~~~~kn~~~~l~y~~L~~h~l~ 211 (312) | |+++..|-...+.+ ++-.++ T Consensus 144 ~---SAk~~~nV~e~F~~---l~~~i~ 164 (166) T cd04122 144 C---SAKTGENVEDAFLE---TAKKIY 164 (166) T ss_pred E---ECCCCCCHHHHHHH---HHHHHH T ss_conf 9---71589887899999---999985 No 27 >e1x3sa1 c.37.1.8 (A:2-178) Rab18 {Human (Homo sapiens) [TaxID:9606]} Probab=97.50 E-value=0.017 Score=37.19 Aligned_columns=170 Identities=8% Q ss_pred CCCCCCCCEEEEECCCCHHHHHHHHHHCC-CCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHC Q ss_conf 65536644389975983317999998514-77865566557502563356212133268899860785435887887718 Q Fun_Sc_NP_0140 19 NSTETATITAIIYSPSSKTLHQFINICFP-EGSNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQ 97 (312) Q Consensus 19 ~~k~~~~k~~lilg~~~~~~~~fi~~l~~-~~~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~ 97 (312) +....++..++++|....||++|++++.. .-...+..+.+.+|....+..+ +.++.+-+.+.+..... ..+. T Consensus 1 ~~~~~~~iKi~ivG~~~vGKTtLi~~~~~~~~~~~~~~t~~~~~~~~~~~~~---~~~~~~~l~d~~~~~~~----~~~~ 73 (177) T e1x3sa1 1 DEDVLTTLKILIIGESGVGKSSLLLRFTDDTFDPELAATIGVDFKVKTISVD---GNKAKLAIWDTAGQERF----RTLT 73 (177) T ss_pred CCCCCCEEEEEEECCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEEEC---CEEEEEEEECCCCCHHH----HHHH T ss_conf 9666661358998079987999999986481167514641013567899887---94899997116531022----2330 Q ss_pred CCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCC--CCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHH Q ss_conf 77878279998516663446899999999998640689--9873899847734566553245411578899999999999 Q Fun_Sc_NP_0140 98 EHSSKVRWLILLDWTLNDQKLWLNELSYAFNKIKQLND--DNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFC 175 (312) Q Consensus 98 ~~s~~~l~ViLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~--Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvc 175 (312) .......-++++-....++..+-+ +..|+..+++... +.+++||+.|+| |++.. ...++ ++.++ T Consensus 74 ~~~~~~~d~~i~~~d~~~~~s~~~-~~~~~~~i~~~~~~~~~~iiiv~nK~D----l~~~~-v~~~e--------~~~~~ 139 (177) T e1x3sa1 74 PSYYRGAQGVILVYDVTRRDTFVK-LDNWLNELETYCTRNDIVNMLVGNKID----KENRE-VDRNE--------GLKFA 139 (177) T ss_pred HHHCCCCCEEEEECCCCCCHHHHH-HHHHHHHHHHHCCCCCCCEEEECCCCH----HHCCC-CCHHH--------HHHHH T ss_conf 433157606898504676101000-135899999745766632245301100----11046-78889--------99999 Q ss_pred HHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCC Q ss_conf 8829415885256531355566778888753001247787 Q Fun_Sc_NP_0140 176 YFNDSSLFYICEDHTEEKREEAQRLKYQELLKHFCEDRDM 215 (312) Q Consensus 176 L~yGASLiYts~ts~~~~kn~~~~l~y~~L~~h~l~~~~~ 215 (312) -.+|+..+.+ |+....|-..++.. +++.++.-|. T Consensus 140 ~~~~~~~~e~---Sa~~g~gi~e~f~~---i~~~i~~~~~ 173 (177) T e1x3sa1 140 RKHSMLFIEA---SAKTCDGVQCAFEE---LVEKIIQTPG 173 (177) T ss_pred HHCCCEEEEE---ECCCCCCHHHHHHH---HHHHHHCCCC T ss_conf 9659829998---61688787899999---9999850777 No 28 >cd01866 Rab2 Rab2 subfamily. Rab2 is localized on cis-Golgi membranes and interacts with Golgi matrix proteins. Rab2 is also implicated in the maturation of vesicular tubular clusters (VTCs), which are microtubule-associated intermediates in transport between the ER and Golgi apparatus. In plants, Rab2 regulates vesicle trafficking between the ER and the Golgi bodies and is important to pollen tube growth. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site at the C-terminus, with sequence motifs CC, CXC, or CCX. Lipid binding is essential for membrane attachment, a key featur Probab=97.50 E-value=0.027 Score=36.01 Aligned_columns=158 Identities=8% Q ss_pred EEEECCCCHHHHHHHHHHCC-CCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCC-CCCEE Q ss_conf 89975983317999998514-77865566557502563356212133268899860785435887887718778-78279 Q Fun_Sc_NP_0140 28 AIIYSPSSKTLHQFINICFP-EGSNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHS-SKVRW 105 (312) Q Consensus 28 ~lilg~~~~~~~~fi~~l~~-~~~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s-~~~l~ 105 (312) ++++|..+-|||+|+.+... .-.+.+.+..|.+|....+.- ++..+.+-+.+.+.-+.- ..+.+.- .+.-. T Consensus 7 ivliGd~~VGKTsli~r~~~~~f~~~~~~Ti~~~~~~k~i~~---~~~~v~l~iwDt~G~e~~----~~l~~~~~~~a~~ 79 (168) T cd01866 7 YIIIGDTGVGKSCLLLQFTDKRFQPVHDLTIGVEFGARMITI---DGKQIKLQIWDTAGQESF----RSITRSYYRGAAG 79 (168) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEECCC---CCCEEEEEEEECCCCCCH----HHHHHHHCCCCCE T ss_conf 999816984389999998548257544530000001232146---784289998753888411----2453653479977 Q ss_pred EEEE-CCCCCCHHHHHHHHHHHHHHHHC-CCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEE Q ss_conf 9985-16663446899999999998640-689987389984773456655324541157889999999999988294158 Q Fun_Sc_NP_0140 106 LILL-DWTLNDQKLWLNELSYAFNKIKQ-LNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSLF 183 (312) Q Consensus 106 ViLL-DWs~~Dp~~Wlr~Lr~~~~~L~~-l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGASLi 183 (312) +|++ |-+. +..+ ..+..|+...++ .+...++++|-.|+| |+++. ....++ .+.++-++|+..+ T Consensus 80 ~iivfdvt~--~~Sf-~~i~~w~~~~~~~~~~~~piilVGnK~D----L~~~r-~v~~~e-------~~~~a~~~~~~~~ 144 (168) T cd01866 80 ALLVYDITR--RETF-NHLTSWLEDARQHSNSNMTIMLIGNKCD----LESRR-EVSYEE-------GEAFAKEHGLIFM 144 (168) T ss_pred EEEEEECCC--HHHH-HHHHHHHHHHHHHCCCCCEEEEEECCHH----HHHHC-CCCHHH-------HHHHHHHCCCEEE T ss_conf 999976699--7789-9999999999973699968999833201----23304-776889-------9999996598499 Q ss_pred EECCCCCHHHHHHHHHHHHHHHHHHCCCCC Q ss_conf 852565313555667788887530012477 Q Fun_Sc_NP_0140 184 YICEDHTEEKREEAQRLKYQELLKHFCEDR 213 (312) Q Consensus 184 Yts~ts~~~~kn~~~~l~y~~L~~h~l~~~ 213 (312) -+ |+++..|-...+.. ++..++.+ T Consensus 145 E~---SAkt~~nV~~~F~~---la~~i~~~ 168 (168) T cd01866 145 ET---SAKTASNVEEAFIN---TAKEIYEK 168 (168) T ss_pred EE---ECCCCCCHHHHHHH---HHHHHHHC T ss_conf 98---61579887899999---99999719 No 29 >2g6b_A RAS-related protein RAB-26; G-protein, GTP analogue, structural genomics, structural genomics consortium, SGC; HET: GNP; 2.00A {Homo sapiens} SCOP: c.37.1.8 Probab=97.49 E-value=0.023 Score=36.36 Aligned_columns=166 Identities=8% Q ss_pred EEEECCCCHHHHHHHHHHCCCC--CCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCCCCEE Q ss_conf 8997598331799999851477--86556655750256335621213326889986078543588788771877878279 Q Fun_Sc_NP_0140 28 AIIYSPSSKTLHQFINICFPEG--SNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHSSKVRW 105 (312) Q Consensus 28 ~lilg~~~~~~~~fi~~l~~~~--~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s~~~l~ 105 (312) ++++|..+.||++|+.++.... .+.+....+..+....+... .....+.+|-..+.-.... ........-.-+ T Consensus 13 I~ivG~~~vGKTSLl~~~~~~~~~~~~~~~t~~~~~~~~~i~~~-~~~~~l~i~D~~~~~~~~~----~~~~~~~~ad~~ 87 (180) T 2g6b_A 13 VMLVGDSGVGKTCLLVRFKDGAFLAGTFISTVGIDFRNKVLDVD-GVKVKLQMWDTAGQERFRS----VTHAYYRDAHAL 87 (180) T ss_dssp EEEECSTTSSHHHHHHHHHHSCCCCCCCCCCCSCEEEEEEEEET-TEEEEEEEEECCCC------------CCGGGCSEE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEEEC-CCCCCEEEEECCCCCCCCC----CHHHHHCCCCEE T ss_conf 88881699778999999864853677433213201367789755-7431024751466543330----003554388627 Q ss_pred EEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEE Q ss_conf 99851666344689999999999864068998738998477345665532454115788999999999998829415885 Q Fun_Sc_NP_0140 106 LILLDWTLNDQKLWLNELSYAFNKIKQLNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSLFYI 185 (312) Q Consensus 106 ViLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGASLiYt 185 (312) ++..|-+. +...-+....+....+....+-+++||..|+|....-+-.. +-++.++-++|+..+.+ T Consensus 88 i~v~d~~~--~~s~~~~~~~~~~i~~~~~~~~piivv~nK~D~~~~~~v~~------------~~~~~~~~~~~~~~~e~ 153 (180) T 2g6b_A 88 LLLYDVTN--KASFDNIQAWLTEIHEYAQHDVALMLLGNKVDSAHERVVKR------------EDGEKLAKEYGLPFMET 153 (180) T ss_dssp EEEEETTC--HHHHHTHHHHHHHHHHHSCTTCEEEEEEECCSTTSCCCSCH------------HHHHHHHHHHTCCEEEC T ss_pred EEECCCCC--HHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCH------------HHHHHHHHHCCCEEEEE T ss_conf 99812663--14444456667788640689815899850124344453588------------99999999659909998 Q ss_pred CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCC Q ss_conf 256531355566778888753001247787752 Q Fun_Sc_NP_0140 186 CEDHTEEKREEAQRLKYQELLKHFCEDRDMKDH 218 (312) Q Consensus 186 s~ts~~~~kn~~~~l~y~~L~~h~l~~~~~~~~ 218 (312) |+....|...++.. ++..+..+..+.| T Consensus 154 ---Sa~~g~gI~~~f~~---i~~~l~~~~~~~P 180 (180) T 2g6b_A 154 ---SAKTGLNVDLAFTA---IAKELKRRSMKAP 180 (180) T ss_dssp ---CTTTCTTHHHHHHH---HHHHHHC------ T ss_pred ---ECCCCCCHHHHHHH---HHHHHHHHHCCCC T ss_conf ---62689788899999---9999998312789 No 30 >d1ek0a_ c.37.1.8 (A:) Ypt51 {Baker's yeast (Saccharomyces cerevisiae)} Probab=97.48 E-value=0.11 Score=32.27 Aligned_columns=165 Identities=7% Q ss_pred CCCEEEEECCCCHHHHHHHHHHCC-CCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCCC Q ss_conf 644389975983317999998514-7786556655750256335621213326889986078543588788771877878 Q Fun_Sc_NP_0140 24 ATITAIIYSPSSKTLHQFINICFP-EGSNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHSSK 102 (312) Q Consensus 24 ~~k~~lilg~~~~~~~~fi~~l~~-~~~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s~~ 102 (312) ++..++++|..+.||++|++++.. .-.+.+.++.+.+|....+.-+ ....++..|-..|.-.. ..+.+..+ ..- T Consensus 2 ~~iKi~ivG~~~vGKTsli~~l~~~~~~~~~~~t~~~~~~~~~i~~~-~~~~~~~i~D~~g~~~~-~~~~~~~~---~~~ 76 (170) T d1ek0a_ 2 TSIKLVLLGEAAVGKSSIVLRFVSNDFAENKEPTIGAAFLTQRVTIN-EHTVKFEIWDTAGQERF-ASLAPXYY---RNA 76 (170) T ss_dssp EEEEEEEECSTTSSHHHHHHHHHHSCCCTTCCCCSSEEEEEEEEEET-TEEEEEEEEEECCSGGG-GGGHHHHH---TTC T ss_pred CEEEEEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEEEC-CEEEEEEEECCCCCHHH-HHHHHHHH---CCC T ss_conf 73889998079987999999986483357635315533567789998-96899987226682245-55525440---357 Q ss_pred CEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEE Q ss_conf 27999851666344689999999999864068998738998477345665532454115788999999999998829415 Q Fun_Sc_NP_0140 103 VRWLILLDWTLNDQKLWLNELSYAFNKIKQLNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSL 182 (312) Q Consensus 103 ~l~ViLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGASL 182 (312) .-++++.|-+ |+..+-..-..+-...+......++++|..|+|....-...... ++-.+.++-.+++.. T Consensus 77 d~~i~v~d~~--~~~s~~~~~~~~~~i~~~~~~~~~~iiv~nK~D~~~~~~~~~i~---------~~~~~~~~~~~~~~~ 145 (170) T d1ek0a_ 77 QAALVVYDVT--KPQSFIKARHWVKELHEQASKDIIIALVGNKIDXLQEGGERKVA---------REEGEKLAEEKGLLF 145 (170) T ss_dssp SEEEEEEETT--CHHHHHHHHHHHHHHHHHSCTTCEEEEEEECGGGGGSSCCCCSC---------HHHHHHHHHHHTCEE T ss_pred CCEEEEEEEC--CCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCC---------HHHHHHHHHHCCCEE T ss_conf 8418999741--61236789999999986421587279997175521115654217---------789999999559849 Q ss_pred EEECCCCCHHHHHHHHHHHHHHHHHHCC Q ss_conf 8852565313555667788887530012 Q Fun_Sc_NP_0140 183 FYICEDHTEEKREEAQRLKYQELLKHFC 210 (312) Q Consensus 183 iYts~ts~~~~kn~~~~l~y~~L~~h~l 210 (312) +.+ |++...|...++.. +...+ T Consensus 146 ~e~---Sa~~~~gi~e~f~~---i~~~i 167 (170) T d1ek0a_ 146 FET---SAKTGENVNDVFLG---IGEKI 167 (170) T ss_dssp EEC---CTTTCTTHHHHHHH---HHTTS T ss_pred EEE---ECCCCCCHHHHHHH---HHHHC T ss_conf 998---62689788899999---99855 No 31 >cd04106 Rab23_lke Rab23-like subfamily. Rab23 is a member of the Rab family of small GTPases. In mouse, Rab23 has been shown to function as a negative regulator in the sonic hedgehog (Shh) signalling pathway. Rab23 mediates the activity of Gli2 and Gli3, transcription factors that regulate Shh signaling in the spinal cord, primarily by preventing Gli2 activation in the absence of Shh ligand. Rab23 also regulates a step in the cytoplasmic signal transduction pathway that mediates the effect of Smoothened (one of two integral membrane proteins that are essential components of the Shh signaling pathway in vertebrates). In humans, Rab23 is expressed in the retina. Mice contain an isoform that shares 93% sequence identity with the human Rab23 and an alternative splicing isoform that is specific to the brain. This isoform causes the murine open brain phenotype, indicating it may have a role in the development of the central nervous system. GTPase activating proteins (GAPs) interact with G Probab=97.47 E-value=0.03 Score=35.73 Aligned_columns=159 Identities=8% Q ss_pred EEEECCCCHHHHHHHHHHCC-CCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCCCCEEE Q ss_conf 89975983317999998514-77865566557502563356212133268899860785435887887718778782799 Q Fun_Sc_NP_0140 28 AIIYSPSSKTLHQFINICFP-EGSNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHSSKVRWL 106 (312) Q Consensus 28 ~lilg~~~~~~~~fi~~l~~-~~~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s~~~l~V 106 (312) ++++|+.+-|||+|+.+... .-.+.+.+..|.+|....+.-+ ..+..+.+-+-+.+..+.-..+.+..-..+.-.++| T Consensus 3 i~~iGd~~vGKTsli~r~~~~~f~~~~~~Tig~~~~~k~v~v~-~~~~~v~l~iwDt~g~e~~~~~~~~~~~~~~~~llv 81 (162) T cd04106 3 VIVVGNGNVGKSSMIQRFVKGIFTKDYKKTIGVDFLEKQIFLR-QSDEDVRLMLWDTAGQEEFDAITKAYYRGAQACILV 81 (162) T ss_pred EEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEEE-ECCEEEEEEEECCCCCCHHHHHHHHHCCCCCEEEEE T ss_conf 8998079844899999986282275556410104677789970-088479999871888800345537641489789999 Q ss_pred EEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEC Q ss_conf 98516663446899999999998640689987389984773456655324541157889999999999988294158852 Q Fun_Sc_NP_0140 107 ILLDWTLNDQKLWLNELSYAFNKIKQLNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSLFYIC 186 (312) Q Consensus 107 iLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGASLiYts 186 (312) + +..|+...-+ +..|...++....+.++++|-.|+|-...-+=.. +-.+.+|-.+|+..|-| T Consensus 82 y----dvt~~~Sf~~-i~~w~~~i~~~~~~~p~ilVGNK~Dl~~~~~vs~------------~~~~~~a~~~~~~~~E~- 143 (162) T cd04106 82 F----STTDRESFEA-IESWKEKVEAECGDIPMVLVQTKIDLLDQAVITN------------EEAEALAKRLQLPLFRT- 143 (162) T ss_pred E----ECCCHHHHHH-HHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCH------------HHHHHHHHHCCCCEEEE- T ss_conf 8----6699789999-9999999998549937999821423212465898------------99999999669959999- Q ss_pred CCCCHHHHHHHHHHHHHHHHHHCC Q ss_conf 565313555667788887530012 Q Fun_Sc_NP_0140 187 EDHTEEKREEAQRLKYQELLKHFC 210 (312) Q Consensus 187 ~ts~~~~kn~~~~l~y~~L~~h~l 210 (312) |+++..|-...+.+ ++.++ T Consensus 144 --SAk~~~nV~e~F~~---la~k~ 162 (162) T cd04106 144 --SVKDDFNVTELFEY---LAEKC 162 (162) T ss_pred --ECCCCCCHHHHHHH---HHHHC T ss_conf --71589887899999---98509 No 32 >1oix_A RAS-related protein RAB-11A; small G protein, intracellular trafficking, GTP-binding, lipoprotein, prenylation, protein transport; HET: GDP; 1.7A {Homo sapiens} SCOP: c.37.1.8 Probab=97.47 E-value=0.038 Score=35.15 Aligned_columns=159 Identities=9% Q ss_pred EEEECCCCHHHHHHHHHHCCCC-CCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCCCCEEE Q ss_conf 8997598331799999851477-865566557502563356212133268899860785435887887718778782799 Q Fun_Sc_NP_0140 28 AIIYSPSSKTLHQFINICFPEG-SNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHSSKVRWL 106 (312) Q Consensus 28 ~lilg~~~~~~~~fi~~l~~~~-~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s~~~l~V 106 (312) ++++|+...||++|++++.... .+.+.++.+.......+..+ .....+..|-..+.-......-..+-+++. ++ T Consensus 32 I~iiG~~~vGKSSLi~~l~~~~~~~~~~~t~~~~~~~~~~~~~-~~~~~~~i~d~~g~~~~~~~~~~~~~~~d~----ii 106 (191) T 1oix_A 32 VVLIGDSGVGKSNLLSRFTRNEFNLESKSTIGVEFATRSIQVD-GKTIKAQIWDTAGLERYRAITSAYYRGAVG----AL 106 (191) T ss_dssp EEEEECTTSSHHHHHHHHHHSCCCCSCCCCCSEEEEEEEEEET-TEEEEEEEEEECSCCSSSCCCHHHHTTCCE----EE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEE-CEEEEEEEECCCCCHHHHHHHHHHCCCCCE----EE T ss_conf 9998179977899999986482564443321220110268750-213444551477720234567764136765----89 Q ss_pred EEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEC Q ss_conf 98516663446899999999998640689987389984773456655324541157889999999999988294158852 Q Fun_Sc_NP_0140 107 ILLDWTLNDQKLWLNELSYAFNKIKQLNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSLFYIC 186 (312) Q Consensus 107 iLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGASLiYts 186 (312) ++.|-+ |+..+-..-..+-...+....+.++++|++|+| |.++.-...++ ++.+|-.+|...+.+ T Consensus 107 lv~d~~--~~~S~~~~~~~~~~i~~~~~~~~piiivgnK~D----l~~~~~i~~~e--------~~~~~~~~~~~~~ev- 171 (191) T 1oix_A 107 LVYDIA--KHLTYENVERWLKELRDHADSNIVIMLVGNKSD----LRHLRAVPTDE--------ARAFAEKNGLSFIET- 171 (191) T ss_dssp EEEETT--CHHHHHTHHHHHHHHHHHSCTTCEEEEEEECGG----GGGGCCSCHHH--------HHHHHHHTTCEEEEC- T ss_pred EEEEEC--CCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCC----CCCCCCCCHHH--------HHHHHHHCCCCEEEE- T ss_conf 997507--753068999988877763289977999841433----00003688899--------999999639938999- Q ss_pred CCCCHHHHHHHHHHHHHHHHHHCCC Q ss_conf 5653135556677888875300124 Q Fun_Sc_NP_0140 187 EDHTEEKREEAQRLKYQELLKHFCE 211 (312) Q Consensus 187 ~ts~~~~kn~~~~l~y~~L~~h~l~ 211 (312) |++...|-..++.. ++..+| T Consensus 172 --Sak~~~~I~elf~~---i~~~iy 191 (191) T 1oix_A 172 --SALDSTNVEAAFQT---ILTEIY 191 (191) T ss_dssp --CTTTCTTHHHHHHH---HHHHHC T ss_pred --ECCCCCCHHHHHHH---HHHHCC T ss_conf --61688688899999---999709 No 33 >d1r2qa_ c.37.1.8 (A:) Rab5a {Human (Homo sapiens)} Probab=97.45 E-value=0.14 Score=31.77 Aligned_columns=168 Identities=7% Q ss_pred CCCCCCCEEEEECCCCHHHHHHHHHHCC-CCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCC Q ss_conf 5536644389975983317999998514-778655665575025633562121332688998607854358878877187 Q Fun_Sc_NP_0140 20 STETATITAIIYSPSSKTLHQFINICFP-EGSNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQE 98 (312) Q Consensus 20 ~k~~~~k~~lilg~~~~~~~~fi~~l~~-~~~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~ 98 (312) |...+.-.++++|....||++|++++.. .-.+.+..+...+|....+..+ ....++.+|--.+.-.........+ T Consensus 1 ~~~~~~~ki~liG~~~vGKSsli~~~~~~~~~~~~~~t~~~~~~~~~~~~~-~~~~~~~i~d~~g~~~~~~~~~~~~--- 76 (170) T d1r2qa_ 1 GNKICQFKLVLLGESAVGKSSLVLRFVKGQFHEFQESTIGAAFLTQTVCLD-DTTVKFEIWDTAGQERYHSLAPMYY--- 76 (170) T ss_dssp CCEEEEEEEEEECSTTSSHHHHHHHHHHSCCCTTCCCCSSEEEEEEEEEET-TEEEEEEEEEECCSGGGGGGHHHHH--- T ss_pred CCCCEEEEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEEC-CEEEEEEEECCCCCCHHHHHHHHHH--- T ss_conf 986114789998179987999999986480156624420245434545557-9179998730677301123215540--- Q ss_pred CCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHC Q ss_conf 78782799985166634468999999999986406899873899847734566553245411578899999999999882 Q Fun_Sc_NP_0140 99 HSSKVRWLILLDWTLNDQKLWLNELSYAFNKIKQLNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFN 178 (312) Q Consensus 99 ~s~~~l~ViLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~y 178 (312) ..-.-++++.|-+. +...-..-.-.-...+....+-++++|..|+|-....+-.. +-++.++-.+ T Consensus 77 -~~~~~~i~v~d~~~--~~s~~~~~~~~~~~~~~~~~~~piilVgnK~Dl~~~~~v~~------------~~~~~~~~~~ 141 (170) T d1r2qa_ 77 -RGAQAAIVVYDITN--EESFARAKNWVKELQRQASPNIVIALSGNKADLANKRAVDF------------QEAQSYADDN 141 (170) T ss_dssp -TTCSEEEEEEETTC--HHHHHHHHHHHHHHHHHSCTTCEEEEEEECGGGGGGCCSCH------------HHHHHHHHHT T ss_pred -CCCCEEEEEEECCC--HHHHHHHHHHHHHHHHHCCCCEEEEEEEEHHHHHHHCCCCH------------HHHHHHHHHC T ss_conf -46528999962530--14689999999998750378557775320010221047798------------9999999955 Q ss_pred CCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCC Q ss_conf 9415885256531355566778888753001247 Q Fun_Sc_NP_0140 179 DSSLFYICEDHTEEKREEAQRLKYQELLKHFCED 212 (312) Q Consensus 179 GASLiYts~ts~~~~kn~~~~l~y~~L~~h~l~~ 212 (312) |+..+.+ |++...+-..++.. ++..+++ T Consensus 142 ~~~~~e~---Sa~~~~gi~elf~~---l~~~i~~ 169 (170) T d1r2qa_ 142 SLLFMET---SAKTSMNVNEIFMA---IAKKLPK 169 (170) T ss_dssp TCEEEEC---CTTTCTTHHHHHHH---HHHTSCC T ss_pred CCEEEEE---ECCCCCCHHHHHHH---HHHHHCC T ss_conf 9818998---62689788899999---9998325 No 34 >2p5s_A RAS and EF-hand domain containing; G-protein, RAB, GDP, structural genomics, SGC, structural genomics consortium; HET: GDP; 2.15A {Homo sapiens} Probab=97.43 E-value=0.039 Score=35.07 Aligned_columns=166 Identities=11% Q ss_pred EEEECCCCHHHHHHHHHHCC-CCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCCCCEEE Q ss_conf 89975983317999998514-77865566557502563356212133268899860785435887887718778782799 Q Fun_Sc_NP_0140 28 AIIYSPSSKTLHQFINICFP-EGSNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHSSKVRWL 106 (312) Q Consensus 28 ~lilg~~~~~~~~fi~~l~~-~~~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s~~~l~V 106 (312) ++++|+.+.||++|++++.. .-.+.+..+.+..+....+..+ .+...+..|-..+......-.-..+-++ ..++ T Consensus 31 I~ivG~~~vGKSsLi~~l~~~~~~~~~~~t~~~~~~~~~i~~~-~~~~~l~i~d~~~~~~~~~~~~~~~~~~----d~~i 105 (199) T 2p5s_A 31 IVLAGDAAVGKSSFLMRLCKNEFRENISATLGVDFQMKTLIVD-GERTVLQLWDTAGQERFRSIAKSYFRKA----DGVL 105 (199) T ss_dssp EEEESSTTSSHHHHHHHHHHCCCC----------CEEEEEEET-TEEEEEEEEECTTCTTCHHHHHHHHHHC----SEEE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEEEC-CCEEEEEEECCCCHHHHHHHHHHHHHHH----CCEE T ss_conf 9998079987999999986581256514540246788887415-6214564202541245567889875330----0224 Q ss_pred EEECCCCCCHHHHHHHHHHHHHHHHC-CCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEE Q ss_conf 98516663446899999999998640-68998738998477345665532454115788999999999998829415885 Q Fun_Sc_NP_0140 107 ILLDWTLNDQKLWLNELSYAFNKIKQ-LNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSLFYI 185 (312) Q Consensus 107 iLLDWs~~Dp~~Wlr~Lr~~~~~L~~-l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGASLiYt 185 (312) +..|-+ |+...-. ++.|+..+++ .....+++||-+|+|.......+. -+....+...++-+ .+|+..+.+ T Consensus 106 lv~d~~--~~~s~~~-~~~~~~~i~~~~~~~~Piiiv~nK~Dl~~~~~~~~--~~~i~~~~~~~~a~----~~~~~~~~~ 176 (199) T 2p5s_A 106 LLYDVT--CEKSFLN-IREWVDMIEDAAHETVPIMLVGNKADIRDTAATEG--QKCVPGHFGEKLAM----TYGALFCET 176 (199) T ss_dssp EEEETT--CHHHHHT-HHHHHHHHHHHC---CCEEEEEECGGGHHHHHHTT--CCCCCHHHHHHHHH----HHTCEEEEC T ss_pred EEEHHC--CHHHHHH-HHCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHH--HHCCCHHHHHHHHH----HCCCEEEEE T ss_conf 320010--2023333-21000121113689727988211256023444444--31346889999998----559869998 Q ss_pred CCCCCHHHHHHHHHHHHHHHHHHCCCCC Q ss_conf 2565313555667788887530012477 Q Fun_Sc_NP_0140 186 CEDHTEEKREEAQRLKYQELLKHFCEDR 213 (312) Q Consensus 186 s~ts~~~~kn~~~~l~y~~L~~h~l~~~ 213 (312) |++...+...++.. +.+.+..+ T Consensus 177 ---Sak~g~gi~e~f~~---i~~~i~k~ 198 (199) T 2p5s_A 177 ---SAKDGSNIVEAVLH---LAREVKKR 198 (199) T ss_dssp ---CTTTCTTHHHHHHH---HHHHHTC- T ss_pred ---ECCCCCCHHHHHHH---HHHHHHHC T ss_conf ---52579888999999---99999733 No 35 >2fg5_A RAB-22B, RAS-related protein RAB-31; G-protein, GTP analogue, structural genomics, structural genomics consortium, SGC; HET: GNP; 2.80A {Homo sapiens} SCOP: c.37.1.8 Probab=97.43 E-value=0.08 Score=33.21 Aligned_columns=164 Identities=4% Q ss_pred EEEECCCCHHHHHHHHHHCCCC-CCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCCCCEEE Q ss_conf 8997598331799999851477-865566557502563356212133268899860785435887887718778782799 Q Fun_Sc_NP_0140 28 AIIYSPSSKTLHQFINICFPEG-SNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHSSKVRWL 106 (312) Q Consensus 28 ~lilg~~~~~~~~fi~~l~~~~-~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s~~~l~V 106 (312) ++++|..+.||++|++++.... ...+.++.+..|....+..+ ....++.+|-..+........-..+-.++ + T Consensus 26 I~iiG~~~vGKSsLi~~l~~~~~~~~~~~T~~~~~~~~~~~~~-~~~~~~~i~d~~~~~~~~~~~~~~~~~~~------~ 98 (192) T 2fg5_A 26 VCLLGDTGVGKSSIVCRFVQDHFDHNISPTIGASFMTKTVPCG-NELHKFLIWDTAGQERFHSLAPMYYRGSA------A 98 (192) T ss_dssp EEEEECTTSSHHHHHHHHHHCCCCTTCCCCSSEEEEEEEEECS-SSEEEEEEEEECCSGGGGGGTHHHHTTCS------E T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEECCC-CEEEEEECCCCCHHHHHHHHHHHHHHHHH------H T ss_conf 9998069976899999987281067767622334566641046-50111000001002355678888763111------0 Q ss_pred EEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEC Q ss_conf 98516663446899999999998640689987389984773456655324541157889999999999988294158852 Q Fun_Sc_NP_0140 107 ILLDWTLNDQKLWLNELSYAFNKIKQLNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSLFYIC 186 (312) Q Consensus 107 iLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGASLiYts 186 (312) +++-+...++...-.....+-...+......+++||+.|+|-...-+... +.++.+|-.+|+.++.+ T Consensus 99 ~i~v~d~~~~~s~~~i~~~~~~i~~~~~~~~~iilVgnK~Dl~~~~~~~~------------~~~~~~~k~~~~~~~ev- 165 (192) T 2fg5_A 99 AVIVYDITKQDSFYTLKKWVKELKEHGPENIVMAIAGNKCDLSDIREVPL------------KDAKEYAESIGAIVVET- 165 (192) T ss_dssp EEEEEETTCTHHHHHHHHHHHHHHHHSCTTCEEEEEEECGGGGGGCCSCH------------HHHHHHHHTTTCEEEEC- T ss_pred EEEEECCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHCCCCH------------HHHHHHHHHCCCEEEEE- T ss_conf 01221034405689999999999872589706888505220001104547------------89999999639859998- Q ss_pred CCCCHHHHHHHHHHHHHHHHHHCCCCCCCC Q ss_conf 565313555667788887530012477877 Q Fun_Sc_NP_0140 187 EDHTEEKREEAQRLKYQELLKHFCEDRDMK 216 (312) Q Consensus 187 ~ts~~~~kn~~~~l~y~~L~~h~l~~~~~~ 216 (312) |+++..|...++.. ++..+...++. T Consensus 166 --Sak~g~gV~elf~~---i~~~i~~~~p~ 190 (192) T 2fg5_A 166 --SAKNAINIEELFQG---ISRQIPPLDPH 190 (192) T ss_dssp --BTTTTBSHHHHHHH---HHHTCC----- T ss_pred --ECCCCCCHHHHHHH---HHHHCCCCCCC T ss_conf --52689788899999---99864678877 No 36 >e2atxa1 c.37.1.8 (A:9-193) RhoQ {Human (Homo sapiens) [TaxID:9606]} SCOP: u2atxb_ Probab=97.42 E-value=0.027 Score=35.97 Aligned_columns=173 Identities=8% Q ss_pred EEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCCCCEEE Q ss_conf 38997598331799999851477865566557502563356212133268899860785435887887718778782799 Q Fun_Sc_NP_0140 27 TAIIYSPSSKTLHQFINICFPEGSNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHSSKVRWL 106 (312) Q Consensus 27 ~~lilg~~~~~~~~fi~~l~~~~~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s~~~l~V 106 (312) .++++|..+.||++|++++.......-............+.-+ .....+.+|-..+.-....-.-.++-..+ .++ T Consensus 11 ki~viG~~~vGKTsli~~~~~~~~~~~~~~t~~~~~~~~i~~~-~~~~~l~i~D~~g~~~~~~~~~~~~~~~d----~~i 85 (185) T e2atxa1 11 KCVVVGDGAVGKTCLLMSYANDAFPEEYVPTVFDHYAVSVTVG-GKQYLLGLYDTAGQEDYDRLRPLSYPMTD----VFL 85 (185) T ss_pred EEEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEEC-CCEEEEEEEECCCCCHHHHHHHHHCCCCE----EEE T ss_conf 9999806998899999998638326763551688888999873-96489998505573112333454314342----567 Q ss_pred EEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEC Q ss_conf 98516663446899999999998640689987389984773456655324541157889999999999988294158852 Q Fun_Sc_NP_0140 107 ILLDWTLNDQKLWLNELSYAFNKIKQLNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSLFYIC 186 (312) Q Consensus 107 iLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGASLiYts 186 (312) ++.|-+ |++++-+..+.|...++....+.++++|..|+|-...-......=...+-..-.+-.+.++-++|+..++-+ T Consensus 86 ~v~D~~--~~~S~~~~~~~~~~~~~~~~~~~piiivgnK~Dl~~~~~~~~~~~~~~~~~v~~~~~~~~a~~~~~~~~~e~ 163 (185) T e2atxa1 86 ICFSVV--NPASFQNVKEEWVPELKEYAPNVPFLLIGTQIDLRDDPKTLARLNDMKEKPICVEQGQKLAKEIGACCYVEC 163 (185) T ss_pred EEEECC--CCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEEEEE T ss_conf 887435--740278877888999986079707999972358765124666554411466788999999997089137887 Q ss_pred CCCCHHHHHHHHHHHHHHHH Q ss_conf 56531355566778888753 Q Fun_Sc_NP_0140 187 EDHTEEKREEAQRLKYQELL 206 (312) Q Consensus 187 ~ts~~~~kn~~~~l~y~~L~ 206 (312) .....+.-+++.--...+.+ T Consensus 164 Sa~t~~gi~e~fe~~i~~~l 183 (185) T e2atxa1 164 SALTQKGLKTVFDEAIIAIL 183 (185) T ss_pred ECCCCCCHHHHHHHHHHHHC T ss_conf 50578787899999999960 No 37 >e1z0ja1 c.37.1.8 (A:2-168) Rab-22a {Mouse (Mus musculus) [TaxID:10090]} SCOP: u1yvda1 u2fg5a1 Probab=97.40 E-value=0.038 Score=35.09 Aligned_columns=159 Identities=6% Q ss_pred EEEECCCCHHHHHHHHHHCCCC-CCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCCCCEEE Q ss_conf 8997598331799999851477-865566557502563356212133268899860785435887887718778782799 Q Fun_Sc_NP_0140 28 AIIYSPSSKTLHQFINICFPEG-SNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHSSKVRWL 106 (312) Q Consensus 28 ~lilg~~~~~~~~fi~~l~~~~-~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s~~~l~V 106 (312) ++++|..+.||++|++++.... .+.+.++.+.+|....+..+ ....++.+|-..|..... ........+.-.+ T Consensus 7 I~iiG~~~~GKTsLl~~l~~~~~~~~~~~t~~~~~~~~~~~~~-~~~~~l~i~d~~g~~~~~-----~~~~~~~~~~~~~ 80 (167) T e1z0ja1 7 VCLLGDTGVGKSSIMWRFVEDSFDPNINPTIGASFMTKTVQYQ-NELHKFLIWDTAGLERFR-----ALAPMYYRGSAAA 80 (167) T ss_pred EEEECCCCCCHHHHHHHHHCCCCCCCCCCCCHHHCCEEEEEEC-CCEEEEEEEECCCCHHHH-----HHHHCCCCCCEEE T ss_conf 8998079988999999986482256545300110000235545-815899973115712454-----4200014786189 Q ss_pred EEECCCCCCHHHHHHHHHHHHHHHHCC-CCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEE Q ss_conf 985166634468999999999986406-8998738998477345665532454115788999999999998829415885 Q Fun_Sc_NP_0140 107 ILLDWTLNDQKLWLNELSYAFNKIKQL-NDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSLFYI 185 (312) Q Consensus 107 iLLDWs~~Dp~~Wlr~Lr~~~~~L~~l-~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGASLiYt 185 (312) +++=... ...=...+..|+..+++. ..+.++++|+.|+| |.+.+ ....++ ++.+.-.+|+..+.+ T Consensus 81 i~v~d~~--~~~s~~~~~~~~~~~~~~~~~~~~iiivgnK~D----l~~~~-~v~~~~-------~~~~~~~~~~~~~e~ 146 (167) T e1z0ja1 81 IIVYDIT--KEETFSTLKNWVRELRQHGPPSIVVAIAGNKCD----LTDVR-EVMERD-------AKDYADSIHAIFVET 146 (167) T ss_pred EEEEECC--CCHHHHHHHHHHHHHHHHCCCCEEEEEEEECCC----CHHHC-CCCHHH-------HHHHHHHCCCEEEEE T ss_conf 9996256--203678888899999860588537899740334----20111-548789-------999999639869998 Q ss_pred CCCCCHHHHHHHHHHHHHHHHHHCCCC Q ss_conf 256531355566778888753001247 Q Fun_Sc_NP_0140 186 CEDHTEEKREEAQRLKYQELLKHFCED 212 (312) Q Consensus 186 s~ts~~~~kn~~~~l~y~~L~~h~l~~ 212 (312) |++...|-..++.. ++..+.. T Consensus 147 ---Sa~~~~~i~elf~~---i~~~i~s 167 (167) T e1z0ja1 147 ---SAKNAININELFIE---ISRRIPS 167 (167) T ss_pred ---ECCCCCCHHHHHHH---HHHHCCC T ss_conf ---61689888899999---9986479 No 38 >cd04110 Rab35 Rab35 subfamily. Rab35 is one of several Rab proteins to be found to participate in the regulation of osteoclast cells in rats. In addition, Rab35 has been identified as a protein that interacts with nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) in human cells. Overexpression of NPM-ALK is a key oncogenic event in some anaplastic large-cell lymphomas; since Rab35 interacts with N|PM-ALK, it may provide a target for cancer treatments. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site at the C-terminus, with sequence motifs CC, CXC, or CCX. Lipid binding is Probab=97.40 E-value=0.038 Score=35.10 Aligned_columns=150 Identities=13% Q ss_pred EEEECCCCHHHHHHHHHHCC-CCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCC--CCCE Q ss_conf 89975983317999998514-77865566557502563356212133268899860785435887887718778--7827 Q Fun_Sc_NP_0140 28 AIIYSPSSKTLHQFINICFP-EGSNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHS--SKVR 104 (312) Q Consensus 28 ~lilg~~~~~~~~fi~~l~~-~~~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s--~~~l 104 (312) ++++|+.+-|||+++.+... .-.+.+....|.+|....+.-+ ....++.+|=-.|---- ..+++.- .-.. T Consensus 9 vv~iGd~~VGKTsli~r~~~~~F~~~y~~Tig~~~~~k~v~i~-~~~~~l~iwDtaGqe~~------~~l~~~y~~~a~~ 81 (199) T cd04110 9 LLIIGDSGVGKSSLLLRFADNTFSGSYITTIGVDFKIRTVEIN-GERVKLQIWDTAGQERF------RTITSTYYRGTHG 81 (199) T ss_pred EEEEECCCCCHHHHHHHHHCCEECCCCCCCEEEEEEEEEEEEC-CEEEEEEEEECCCCCHH------HHHHHHHCCCCCE T ss_conf 9998269843899998876180076646511223578889985-83999999866997035------6776765038987 Q ss_pred EEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEE Q ss_conf 99985166634468999999999986406899873899847734566553245411578899999999999882941588 Q Fun_Sc_NP_0140 105 WLILLDWTLNDQKLWLNELSYAFNKIKQLNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSLFY 184 (312) Q Consensus 105 ~ViLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGASLiY 184 (312) +|+.-|-+. +..+ ..+..|+..+++..++.++++|..|+| |+..+-.-.++...|-.+ +|+..|. T Consensus 82 ~ilVydit~--~~Sf-~~i~~w~~~i~~~~~~~~~iLVGNK~D----l~~~r~v~~ee~~~~a~~--------~~~~f~E 146 (199) T cd04110 82 VIVVYDVTN--GESF-VNVKRWLQEIEQNCDDVCKVLVGNKND----DPERKVVETEDAYKFAGQ--------MGISLFE 146 (199) T ss_pred EEEEEECCC--HHHH-HHHHHHHHHHHHHCCCCCEEEEEECCC----CHHHCCCCHHHHHHHHHH--------CCCCEEE T ss_conf 999987799--7799-999999999985125673699840336----311226568999999996--------6995999 Q ss_pred ECCCCCHHHHHHHHHHHH Q ss_conf 525653135556677888 Q Fun_Sc_NP_0140 185 ICEDHTEEKREEAQRLKY 202 (312) Q Consensus 185 ts~ts~~~~kn~~~~l~y 202 (312) | |+++..|-..++.. T Consensus 147 t---SAktg~nV~e~F~~ 161 (199) T cd04110 147 T---SAKENINVEEMFNC 161 (199) T ss_pred E---ECCCCCCHHHHHHH T ss_conf 9---71589888899999 No 39 >cd04113 Rab4 Rab4 subfamily. Rab4 has been implicated in numerous functions within the cell. It helps regulate endocytosis through the sorting, recycling, and degradation of early endosomes. Mammalian Rab4 is involved in the regulation of many surface proteins including G-protein-coupled receptors, transferrin receptor, integrins, and surfactant protein A. Experimental data implicate Rab4 in regulation of the recycling of internalized receptors back to the plasma membrane. It is also believed to influence receptor-mediated antigen processing in B-lymphocytes, in calcium-dependent exocytosis in platelets, in alpha-amylase secretion in pancreatic cells, and in insulin-induced translocation of Glut4 from internal vesicles to the cell surface. Rab4 is known to share effector proteins with Rab5 and Rab11. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to p Probab=97.39 E-value=0.074 Score=33.40 Aligned_columns=154 Identities=10% Q ss_pred EEEECCCCHHHHHHHHHHCC-CCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCCCCEEE Q ss_conf 89975983317999998514-77865566557502563356212133268899860785435887887718778782799 Q Fun_Sc_NP_0140 28 AIIYSPSSKTLHQFINICFP-EGSNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHSSKVRWL 106 (312) Q Consensus 28 ~lilg~~~~~~~~fi~~l~~-~~~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s~~~l~V 106 (312) ++++|+.+-|||.++.+... .=.+.+.+..|.+|....+.- |+.++.+-+.+.+..+...-+.+.. -..-.-++ T Consensus 3 iviiGd~~VGKTsli~~~~~~~f~~~~~~Tig~~~~~~~i~~---~~~~~~l~i~Dt~G~e~~~~l~~~~--~~~a~~~i 77 (161) T cd04113 3 FIIIGSSGTGKSCLLHRFVENKFKEDSQHTIGVEFGSKIIRV---GGKRVKLQIWDTAGQERFRSVTRSY--YRGAAGAL 77 (161) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEE---CCEEEEEEEEECCCCCHHHHHHHHH--CCCCCEEE T ss_conf 899826985589999998628106665641012013589988---8969999983258870134555864--26997799 Q ss_pred EEECCCCCCHHHHHHHHHHHHHHHHCC-CCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEE Q ss_conf 985166634468999999999986406-8998738998477345665532454115788999999999998829415885 Q Fun_Sc_NP_0140 107 ILLDWTLNDQKLWLNELSYAFNKIKQL-NDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSLFYI 185 (312) Q Consensus 107 iLLDWs~~Dp~~Wlr~Lr~~~~~L~~l-~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGASLiYt 185 (312) +.-|-+. +..+ ..++.|+..++.. +.+.++++|+.|+| |+.+.-...++. +.+|-++|...+.+ T Consensus 78 ivydi~~--~~Sf-~~i~~w~~~~~~~~~~~~~iilvgNK~D----L~~~r~v~~~e~--------~~~a~~~~~~~~e~ 142 (161) T cd04113 78 LVYDITN--RTSF-EALPTWLSDARALASPNIVVILVGNKSD----LADQREVTFLEA--------SRFAQENGLLFLET 142 (161) T ss_pred EEEECCC--HHHH-HHHHHHHHHHHHHCCCCCEEEEEECCCC----CCCCCCCCHHHH--------HHHHHHCCCEEEEE T ss_conf 9985598--6689-9999999999872489968999832456----421334588999--------99999659909999 Q ss_pred CCCCCHHHHHHHHHHHHHH Q ss_conf 2565313555667788887 Q Fun_Sc_NP_0140 186 CEDHTEEKREEAQRLKYQE 204 (312) Q Consensus 186 s~ts~~~~kn~~~~l~y~~ 204 (312) |+++..|-...+...+ T Consensus 143 ---Sak~~~ni~e~F~~la 158 (161) T cd04113 143 ---SALTGENVEEAFLKCA 158 (161) T ss_pred ---ECCCCCCHHHHHHHHH T ss_conf ---7158988889999999 No 40 >1m7b_A RND3/RHOE small GTP-binding protein; small GTPase; HET: GTP; 2.00A {Homo sapiens} SCOP: c.37.1.8 Probab=97.37 E-value=0.034 Score=35.43 Aligned_columns=178 Identities=6% Q ss_pred CCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCE-EEEEEEEECCCHHHHHHHHHHHCC Q ss_conf 5536644389975983317999998514778655665575025633562121332-688998607854358878877187 Q Fun_Sc_NP_0140 20 STETATITAIIYSPSSKTLHQFINICFPEGSNSILDTTLINYATIGWTNDLKENY-SVDVYTLIRNTDDALDLLKPFLQE 98 (312) Q Consensus 20 ~k~~~~k~~lilg~~~~~~~~fi~~l~~~~~e~~~~~~~L~y~y~~v~~d~~d~~-R~~vy~L~~~~~~~~~LLkp~L~~ 98 (312) |++..-..++++|+.+.||++|+.++ -+.+...+..+-........-...+.. .+.+|=..|...... ..-.- T Consensus 2 ~~~~~r~KI~iiG~~~vGKSsLi~~~--~~~~~~~~~~~t~~~~~~~~~~~~~~~~~l~i~D~~g~~~~~~----~~~~~ 75 (184) T 1m7b_A 2 SNQNVKCKIVVVGDSQCGKTALLHVF--AKDCFPENYVPTVFENYTASFEIDTQRIELSLWDTSGSPYYDN----VRPLS 75 (184) T ss_dssp ----CEEEEEEEESTTSSHHHHHHHH--HHSCCCSSCCCCSEEEEEEEEECSSCEEEEEEEEECCSGGGTT----TGGGG T ss_pred CCCCEEEEEEEEECCCCCHHHHHHHH--HCCCCCCCCCCEEEEEEEEEEEECCEEEEEEECCCCCCCCCCC----CCHHH T ss_conf 88542699999817998789999998--6384366635437775655322065347764214544433310----00011 Q ss_pred CCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHH-HHHHHHHHHH Q ss_conf 787827999851666344689999999999864068998738998477345665532454115788999-9999999988 Q Fun_Sc_NP_0140 99 HSSKVRWLILLDWTLNDQKLWLNELSYAFNKIKQLNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFI-LQTLRSFCYF 177 (312) Q Consensus 99 ~s~~~l~ViLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfI-qQ~LRtvcL~ 177 (312) -+.-..+++..|-+ |+..+-+....|...++....+.++++|+.|+|....-.... +...++...| .+-...+|-. T Consensus 76 ~~~~~~ii~v~d~~--~~~sf~~~~~~~~~~~~~~~~~~piilvgnK~D~~~~~~~~~-~~~~~~~~~i~~~~~~~~~~~ 152 (184) T 1m7b_A 76 YPDSDAVLICFDIS--RPETLDSVLKKWKGEIQEFCPNTKMLLVGCKSDLRTDVSTLV-ELSNHRQTPVSYDQGANMAKQ 152 (184) T ss_dssp CTTCSEEEEEEETT--CHHHHHHHHHTHHHHHHHHCTTCEEEEEEECGGGGGCHHHHH-HHHTTTCCCCCHHHHHHHHHH T ss_pred HCCCEEEEEEEECC--CHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHH-HHHHHHCCCCCHHHHHHHHHH T ss_conf 01212466664067--165688888877888876179941899862547543203678-877520335588999999997 Q ss_pred CCCEEEEECCCCCHHH-HHHHHHHHHHHHH Q ss_conf 2941588525653135-5566778888753 Q Fun_Sc_NP_0140 178 NDSSLFYICEDHTEEK-REEAQRLKYQELL 206 (312) Q Consensus 178 yGASLiYts~ts~~~~-kn~~~~l~y~~L~ 206 (312) .|+-.++-+.....++ -++..-+.....+ T Consensus 153 ~~~~~~~E~Sak~~~n~v~e~f~~~~~~~~ 182 (184) T 1m7b_A 153 IGAATYIECSALQSENSVRDIFHVATLACV 182 (184) T ss_dssp HTCSEEEECBTTTBHHHHHHHHHHHHHHHH T ss_pred CCCCEEEEEEECCCCCHHHHHHHHHHHHHH T ss_conf 189538997514687248999999999996 No 41 >d1byub_ c.37.1.8 (B:) Ran {Dog (Canis familiaris)} SCOP: d1qg4b_ Probab=97.36 E-value=0.0046 Score=40.53 Aligned_columns=166 Identities=9% Q ss_pred EEEECCCCHHHHHHHHHHCC-CCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCCCCEEE Q ss_conf 89975983317999998514-77865566557502563356212133268899860785435887887718778782799 Q Fun_Sc_NP_0140 28 AIIYSPSSKTLHQFINICFP-EGSNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHSSKVRWL 106 (312) Q Consensus 28 ~lilg~~~~~~~~fi~~l~~-~~~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s~~~l~V 106 (312) ++++|..+.|||+|+.++.. .-.+.+..+.+.++....+..+ ....++.+|-..|.-.-....-..+..++ .++ T Consensus 12 IiivG~~~vGKTtLi~r~~~~~~~~~~~~Ti~~~~~~~~i~~~-~~~i~l~iwDt~G~e~~~~~~~~~~~~a~----~~i 86 (215) T d1byub_ 12 LVLVGDGGTGKTTFVKRHLTGEFEKKYVPTLGVEVHPLVFHTN-RGPIKFNVWDTAGQEKFGGLRDGYYIQAQ----CAI 86 (215) T ss_dssp EEEECCTTSSHHHHHTTBHHHHHTCEEETTTTEEEEEEEEEET-TEEEEEEEEEECSGGGSSCCCHHHHTTCC----EEE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEEEC-CCEEEEEEEECCCCHHHHHHHHHHCCCCC----EEE T ss_conf 9998179987999999987382156624403456667887518-93124676302330011001110013642----689 Q ss_pred EEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEC Q ss_conf 98516663446899999999998640689987389984773456655324541157889999999999988294158852 Q Fun_Sc_NP_0140 107 ILLDWTLNDQKLWLNELSYAFNKIKQLNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSLFYIC 186 (312) Q Consensus 107 iLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGASLiYts 186 (312) +..|-+. +..+-. ++.|+..++....+.++++|+.|+| |.......+...| +-++|...|-+ T Consensus 87 lv~dvt~--~~s~~~-i~~~~~~i~~~~~~~piilVgNK~D----l~~~~~~~~~~~~----------a~~~~~~~~e~- 148 (215) T d1byub_ 87 IMFDVTS--RVTYKN-VPNWHRDLVRVCENIPIVLCGNKVD----IKDRKVKAKSIVF----------HRKKNLQYYDI- 148 (215) T ss_dssp EEEETTC--HHHHHT-HHHHHHHHHHHHCSCCEEEEEECTT----SSSCCSCHHHHTT----------SCCSSEEEEEE- T ss_pred EEEEECC--HHHHHH-HHHHHHHHHHCCCCCEEEEEECCCC----HHHCCCHHHHHHH----------HHHCCCCEEEE- T ss_conf 8642101--146789-9888876541157641899613343----0010245899999----------99658964888- Q ss_pred CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCE Q ss_conf 56531355566778888753001247787752240 Q Fun_Sc_NP_0140 187 EDHTEEKREEAQRLKYQELLKHFCEDRDMKDHIEM 221 (312) Q Consensus 187 ~ts~~~~kn~~~~l~y~~L~~h~l~~~~~~~~a~v 221 (312) |++...|-...+.+ ++..+.+.+....+.. T Consensus 149 --SAk~~~nv~e~F~~---la~~l~~~~~l~~~~~ 178 (215) T d1byub_ 149 --SAKSNYNFEKPFLW---LARKLIGDPNLEFVAM 178 (215) T ss_dssp --BGGGTBTTTHHHHH---HHHHHHTCTTCCBSSC T ss_pred --EECCCCCHHHHHHH---HHHHHHCCCCCCCCCC T ss_conf --50578887899999---9999852667320123 No 42 >1i2m_A RAN, GTP-binding nuclear protein RAN; beta-propeller, G fold or GTPase fold; 1.76A {Homo sapiens} SCOP: c.37.1.8 Probab=97.36 E-value=0.0079 Score=39.16 Aligned_columns=171 Identities=8% Q ss_pred EEEECCCCHHHHHHHHHHCC-CCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCCCCEEE Q ss_conf 89975983317999998514-77865566557502563356212133268899860785435887887718778782799 Q Fun_Sc_NP_0140 28 AIIYSPSSKTLHQFINICFP-EGSNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHSSKVRWL 106 (312) Q Consensus 28 ~lilg~~~~~~~~fi~~l~~-~~~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s~~~l~V 106 (312) ++++|..+.|||+|++++.. .-.+.+..+.+.+|....+.-+ ....++.+| +.......-...-.--..-..++ T Consensus 13 IvivG~~~vGKTsLi~~~~~~~f~~~~~~Ti~~d~~~~~~~~~-~~~~~l~i~----Dt~g~~~~~~~~~~~~~~~~~~i 87 (216) T 1i2m_A 13 LVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLVFHTN-RGPIKFNVW----DTAGQEKFGGLRDGYYIQAQCAI 87 (216) T ss_dssp EEEEECTTSSHHHHHHTTC-----CCEEEETTEEEEEEEECBT-TCCEEEEEE----ECTTHHHHSSCGGGGTTTCCEEE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEECCC-CCCCCEEEC----CCCCCHHHHHCCHHHHCCCEEEE T ss_conf 9988079987999999986383266524404566655430368-852111222----43110122101001221300123 Q ss_pred EEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEC Q ss_conf 98516663446899999999998640689987389984773456655324541157889999999999988294158852 Q Fun_Sc_NP_0140 107 ILLDWTLNDQKLWLNELSYAFNKIKQLNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSLFYIC 186 (312) Q Consensus 107 iLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGASLiYts 186 (312) +..|-+. +..+-. +..|+..++....+.++++|+.|+|-...-..... ..++-.+|+..+.+ T Consensus 88 ~v~d~~~--~~Sf~~-i~~~~~~~~~~~~~~piilvgnK~Dl~~~~~~~~~--------------~~~~~~~~~~~~e~- 149 (216) T 1i2m_A 88 IMFDVTS--RVTYKN-VPNWHRDLVRVCENIPIVLCGNKVDIKDRKVKAKS--------------IVFHRKKNLQYYDI- 149 (216) T ss_dssp EEEETTS--GGGGTT-HHHHHHHHHHHHCSCCEEEEEECCCCSCSCCTTTS--------------HHHHSSCSSEEEEE- T ss_pred EECCCCC--CCCHHH-HHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHH--------------HHHHHHCCCCEEEE- T ss_conf 1102331--100133-56766666762388258874146652023116899--------------99999648965888- Q ss_pred CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCC Q ss_conf 5653135556677888875300124778775224011563 Q Fun_Sc_NP_0140 187 EDHTEEKREEAQRLKYQELLKHFCEDRDMKDHIEMVTRSE 226 (312) Q Consensus 187 ~ts~~~~kn~~~~l~y~~L~~h~l~~~~~~~~a~vverd~ 226 (312) |++...|-..++.. ++..+...+.........+.. T Consensus 150 --SAk~g~gV~e~f~~---l~~~i~~~~~~~~~~~~~~~~ 184 (216) T 1i2m_A 150 --SAKSNYNFEKPFLW---LARKLIGDPNLEFVAMPALAP 184 (216) T ss_dssp --BTTTTBTTTHHHHH---HHHHHHTCTTCCBC------- T ss_pred --ECCCCCCHHHHHHH---HHHHHHHCCCCCCCCCCCCCC T ss_conf --51679888899999---999985034422112433367 No 43 >e2a5ja1 c.37.1.8 (A:9-181) Rab2b {Human (Homo sapiens) [TaxID:9606]} SCOP: u1z0aa1 u1z0ad_ u1z0ab_ Probab=97.36 E-value=0.033 Score=35.45 Aligned_columns=158 Identities=6% Q ss_pred EEEECCCCHHHHHHHHHHCCCCCCCCCC-CCCCEEEEECCCCCCCCCE-EEEEEEEECCCHHHHHHHHHHHCCCCCCCEE Q ss_conf 8997598331799999851477865566-5575025633562121332-6889986078543588788771877878279 Q Fun_Sc_NP_0140 28 AIIYSPSSKTLHQFINICFPEGSNSILD-TTLINYATIGWTNDLKENY-SVDVYTLIRNTDDALDLLKPFLQEHSSKVRW 105 (312) Q Consensus 28 ~lilg~~~~~~~~fi~~l~~~~~e~~~~-~~~L~y~y~~v~~d~~d~~-R~~vy~L~~~~~~~~~LLkp~L~~~s~~~l~ 105 (312) ++++|..+.||++|++++ -+...... -+.++..+....-...+.. ++..|-..|...........+-+.+ -+ T Consensus 6 V~ivG~~~vGKTsLi~~~--~~~~~~~~~~~t~~~~~~~~~~~~~~~~~~l~i~d~~g~~~~~~~~~~~~~~~d----~~ 79 (173) T e2a5ja1 6 YIIIGDTGVGKSCLLLQF--TDKRFQPVHDLTIGVEFGARMVNIDGKQIKLQIWDTAGQESFRSITRSYYRGAA----GA 79 (173) T ss_pred EEEEECCCCCHHHHHHHH--HCCCCCCCCCCEEEEECCCCCCEECCCEEEEEEEECCCCCCCCCHHHHHHCCCC----EE T ss_conf 999836997799999998--648346663413552001011101585279998614785311000055504897----68 Q ss_pred EEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEE Q ss_conf 99851666344689999999999864068998738998477345665532454115788999999999998829415885 Q Fun_Sc_NP_0140 106 LILLDWTLNDQKLWLNELSYAFNKIKQLNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSLFYI 185 (312) Q Consensus 106 ViLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGASLiYt 185 (312) ++..|-+ |+..+-.....+-...+......+++||+.|+|....-+-.. +-++.+|-++|...+.+ T Consensus 80 i~v~d~~--~~~s~~~~~~~~~~i~~~~~~~~p~iivgnK~Dl~~~~~v~~------------~~~~~~~~~~~~~~~e~ 145 (173) T e2a5ja1 80 LLVYDIT--RRETFNHLTSWLEDARQHSSSNMVIMLIGNKSDLESRRDVKR------------EEGEAFAREHGLIFMET 145 (173) T ss_pred EEEEECC--CHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHCCCCH------------HHHHHHHHHCCCEEEEE T ss_conf 9997426--514678988889998852167612322101124410103208------------89999999649849998 Q ss_pred CCCCCHHHHHHHHHHHHHHHHHHCCC Q ss_conf 25653135556677888875300124 Q Fun_Sc_NP_0140 186 CEDHTEEKREEAQRLKYQELLKHFCE 211 (312) Q Consensus 186 s~ts~~~~kn~~~~l~y~~L~~h~l~ 211 (312) |+++..|-...+.. ++..++ T Consensus 146 ---Saktg~gv~e~F~~---l~~~i~ 165 (173) T e2a5ja1 146 ---SAKTACNVEEAFIN---TAKEIY 165 (173) T ss_pred ---ECCCCCCHHHHHHH---HHHHHH T ss_conf ---51689888899999---999999 No 44 >1z2a_A RAS-related protein RAB-23; RAB GTPase, vesicular trafficking, protein transport; HET: GDP; 1.90A {Mus musculus} SCOP: c.37.1.8 Probab=97.34 E-value=0.026 Score=36.11 Aligned_columns=160 Identities=8% Q ss_pred EEEECCCCHHHHHHHHHHCCCC-CCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCCCCEEE Q ss_conf 8997598331799999851477-865566557502563356212133268899860785435887887718778782799 Q Fun_Sc_NP_0140 28 AIIYSPSSKTLHQFINICFPEG-SNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHSSKVRWL 106 (312) Q Consensus 28 ~lilg~~~~~~~~fi~~l~~~~-~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s~~~l~V 106 (312) ++++|..+.||++|++++.... .+.+.++.+..+....+..+ .....+..|-..+.-.........+ ..-..++ T Consensus 8 i~ivG~~~vGKSsll~~~~~~~~~~~~~~t~~~~~~~~~~~~~-~~~~~~~~~d~~g~~~~~~~~~~~~----~~~~~~i 82 (168) T 1z2a_A 8 MVVVGNGAVGKSSMIQRYCKGIFTKDYKKTIGVDFLERQIQVN-DEDVRLMLWDTAGQEEFDAITKAYY----RGAQACV 82 (168) T ss_dssp EEEECSTTSSHHHHHHHHHHCCCCCCSSCCCSSSEEEEEEEET-TEEEEEEEECCTTGGGTTCCCHHHH----TTCCEEE T ss_pred EEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCEECCCC-CCEEEEEEECCCCCCCCCHHHHHHH----HCCHHHH T ss_conf 9998189977899999986381465422101221000010358-8158986411577531001013443----1101101 Q ss_pred EEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEC Q ss_conf 98516663446899999999998640689987389984773456655324541157889999999999988294158852 Q Fun_Sc_NP_0140 107 ILLDWTLNDQKLWLNELSYAFNKIKQLNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSLFYIC 186 (312) Q Consensus 107 iLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGASLiYts 186 (312) ++.|-+. +...-. ++.|+..++.-..+.++++|..|+|....-+-.. .-++.++-++|+..+.+ T Consensus 83 ~v~d~~~--~~s~~~-~~~~~~~i~~~~~~~~iilvgnK~Dl~~~~~v~~------------~~~~~~a~~~~~~~~e~- 146 (168) T 1z2a_A 83 LVFSTTD--RESFEA-ISSWREKVVAEVGDIPTALVQNKIDLLDDSCIKN------------EEAEGLAKRLKLRFYRT- 146 (168) T ss_dssp EEEETTC--HHHHHT-HHHHHHHHHHHHCSCCEEEEEECGGGGGGCSSCH------------HHHHHHHHHHTCEEEEC- T ss_pred HHHHHHH--HHHHHH-HHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHH------------HHHHHHHHHCCCCEEEE- T ss_conf 1111001--123333-2210000121068823899731357123210047------------89999999659918998- Q ss_pred CCCCHHHHHHHHHHHHHHHHHHCCCCC Q ss_conf 565313555667788887530012477 Q Fun_Sc_NP_0140 187 EDHTEEKREEAQRLKYQELLKHFCEDR 213 (312) Q Consensus 187 ~ts~~~~kn~~~~l~y~~L~~h~l~~~ 213 (312) |+.+..|...++.. ++..++.+ T Consensus 147 --Sa~~~~~i~~l~~~---l~~~~l~k 168 (168) T 1z2a_A 147 --SVKEDLNVSEVFKY---LAEKHLQK 168 (168) T ss_dssp --BTTTTBSSHHHHHH---HHHHHHC- T ss_pred --ECCCCCCHHHHHHH---HHHHHHHC T ss_conf --61589788899999---99999719 No 45 >cd04124 RabL2 RabL2 subfamily. RabL2 (Rab-like2) subfamily. RabL2s are novel Rab proteins identified recently which display features that are distinct from other Rabs, and have been termed Rab-like. RabL2 contains RabL2a and RabL2b, two very similar Rab proteins that share 98% sequence identity in humans. RabL2b maps to the subtelomeric region of chromosome 22q13.3 and RabL2a maps to 2q13, a region that suggests it is also a subtelomeric gene. Both genes are believed to be expressed ubiquitously, suggesting that RabL2s are the first example of duplicated genes in human proximal subtelomeric regions that are both expressed actively. Like other Rab-like proteins, RabL2s lack a prenylation site at the C-terminus. The specific functions of RabL2a and RabL2b remain unknown. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-b Probab=97.33 E-value=0.042 Score=34.85 Aligned_columns=146 Identities=12% Q ss_pred EEEECCCCHHHHHHHHHHCC-CCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCC--CCCE Q ss_conf 89975983317999998514-77865566557502563356212133268899860785435887887718778--7827 Q Fun_Sc_NP_0140 28 AIIYSPSSKTLHQFINICFP-EGSNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHS--SKVR 104 (312) Q Consensus 28 ~lilg~~~~~~~~fi~~l~~-~~~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s--~~~l 104 (312) ++++|+.+-|||+|+.+... .-.+.+....++++....+.-+ .....+.+|=..|.-.- ..+.+.- .-.- T Consensus 3 iiliGd~~VGKTsli~r~~~~~f~~~~~~t~~~~~~~k~~~~~-~~~v~l~iwDt~G~e~~------~~~~~~~~~~a~~ 75 (161) T cd04124 3 IILLGDSAVGKSKLVERFLMDGYEPQQLSTYALTLYKHNAKFE-GKTILVDFWDTAGQERF------QTMHASYYHKAHA 75 (161) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEEC-CEEEEEEEEECCCCCHH------HHHHHHHCCCCCE T ss_conf 8998069944889887865386376623532567899999998-86999999745784110------3566743024785 Q ss_pred EEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEE Q ss_conf 99985166634468999999999986406899873899847734566553245411578899999999999882941588 Q Fun_Sc_NP_0140 105 WLILLDWTLNDQKLWLNELSYAFNKIKQLNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSLFY 184 (312) Q Consensus 105 ~ViLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGASLiY 184 (312) +++.-|-+ -..=...+..|+..+++..++.++++|..|+| |+.+ +.+--+.++-++++..|. T Consensus 76 ~ilvfDit---~~~Sf~~l~~W~~~i~~~~~~~p~ilVGNK~D----l~~~-----------~~~~~~~~a~~~~~~~fe 137 (161) T cd04124 76 CILVFDVT---RKITYKNLSKWYEELREYRPEIPCIVVANKID----LDPS-----------VTQKKFNFAEKHNLPLYY 137 (161) T ss_pred EEEEEECC---CHHHHHHHHHHHHHHHHHCCCCEEEEEECCCC----CCHH-----------HHHHHHHHHHHCCCCEEE T ss_conf 89998669---96688999999999998469937999823765----6435-----------689999999965991999 Q ss_pred ECCCCCHHHHHHHHHHH Q ss_conf 52565313555667788 Q Fun_Sc_NP_0140 185 ICEDHTEEKREEAQRLK 201 (312) Q Consensus 185 ts~ts~~~~kn~~~~l~ 201 (312) | |+++..|-...+. T Consensus 138 t---SAk~g~nV~e~F~ 151 (161) T cd04124 138 V---SAADGTNVVKLFQ 151 (161) T ss_pred E---ECCCCCCHHHHHH T ss_conf 9---7268988789999 No 46 >2fv8_A H6, RHO-related GTP-binding protein RHOB; GDP/GTP binding, GTP hydrolysis, structural genomics, structural genomics consortium, SGC; HET: GDP; 1.90A {Homo sapiens} SCOP: c.37.1.8 Probab=97.31 E-value=0.017 Score=37.15 Aligned_columns=190 Identities=5% Q ss_pred CCCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHH Q ss_conf 11465536644389975983317999998514778655665575025633562121332688998607854358878877 Q Fun_Sc_NP_0140 16 STINSTETATITAIIYSPSSKTLHQFINICFPEGSNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPF 95 (312) Q Consensus 16 ~~~~~k~~~~k~~lilg~~~~~~~~fi~~l~~~~~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~ 95 (312) +.+.-+.....-++++|.++.||++|++++......+.........+...+.-+ .....+..|-..+..... .. T Consensus 16 ~~~~~~~~~~~KI~iiG~~~vGKSSLi~~l~~~~~~~~~~~T~~~~~~~~i~~~-~~~~~l~i~D~~g~~~~~-----~~ 89 (207) T 2fv8_A 16 ENLYFQSMIRKKLVVVGDGACGKTCLLIVFSKDEFPEVYVPTVFENYVADIEVD-GKQVELALWDTAGQEDYD-----RL 89 (207) T ss_dssp ---CGGGSEEEEEEEEECTTSSHHHHHHHHHHSSCC-------CCEEEEEEEET-TEEEEEEEEECTTCTTCT-----TT T ss_pred CCCCHHHHHCEEEEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEEE-EEEEEEECCCCCCCHHHH-----HH T ss_conf 212122130013668816997799999998617457544532552048999872-055643004553201222-----45 Q ss_pred HCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHH Q ss_conf 18778782799985166634468999999999986406899873899847734566553245411578899999999999 Q Fun_Sc_NP_0140 96 LQEHSSKVRWLILLDWTLNDQKLWLNELSYAFNKIKQLNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFC 175 (312) Q Consensus 96 L~~~s~~~l~ViLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvc 175 (312) ...--.+.-.++++-... |+.++-+....|+..++....+.++++|+.|+|-...=+...-.....+...-..-.+.++ T Consensus 90 ~~~~~~~~~~~ilv~d~~-~~~Sf~~i~~~~~~~~~~~~~~~piilVgnK~Dl~~~~~v~~~~~~~~~~~i~~~~~~~~~ 168 (207) T 2fv8_A 90 RPLSYPDTDVILMCFSVD-SPDSLENIPEKWVPEVKHFCPNVPIILVANKKDLRSDEHVRTELARMKQEPVRTDDGRAMA 168 (207) T ss_dssp GGGGCTTCCEEEEEEETT-CHHHHHHHHHTHHHHHHHHSTTCCEEEEEECGGGGGCHHHHHHHHHTTCCCCCHHHHHHHH T ss_pred HHHHHHHHHHHHHEECCC-HHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHH T ss_conf 677544645100001144-0678999888778998630796389971158775301245588998751225678999999 Q ss_pred HHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCC Q ss_conf 882941588525653135556677888875300124778775 Q Fun_Sc_NP_0140 176 YFNDSSLFYICEDHTEEKREEAQRLKYQELLKHFCEDRDMKD 217 (312) Q Consensus 176 L~yGASLiYts~ts~~~~kn~~~~l~y~~L~~h~l~~~~~~~ 217 (312) -+.+..-++- +|++...+....+.. ++..+..+...+ T Consensus 169 ~~~~~~~~~e--~Sa~~~~gi~e~f~~---i~~~~l~kr~~~ 205 (207) T 2fv8_A 169 VRIQAYDYLE--CSAKTKEGVREVFET---ATRAALQKRYGS 205 (207) T ss_dssp HHTTCSEEEE--CCTTTCTTHHHHHHH---HHHHHHSCCCCC T ss_pred HHCCCCEEEE--EECCCCCCHHHHHHH---HHHHHHHHHHCC T ss_conf 9708951899--751688677899999---999999986215 No 47 >2gf9_A RAS-related protein RAB-3D; G-protein, structural genomics, structural genomics consortium, SGC; HET: GDP; 1.53A {Homo sapiens} Probab=97.31 E-value=0.057 Score=34.09 Aligned_columns=172 Identities=11% Q ss_pred CCCCCCCCCCE----EEEECCCCHHHHHHHHHHCCCC-CCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHH Q ss_conf 14655366443----8997598331799999851477-865566557502563356212133268899860785435887 Q Fun_Sc_NP_0140 17 TINSTETATIT----AIIYSPSSKTLHQFINICFPEG-SNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDL 91 (312) Q Consensus 17 ~~~~k~~~~k~----~lilg~~~~~~~~fi~~l~~~~-~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~L 91 (312) .+++-.|++.. ++++|..+.||++|++++..+. .+.+-...+..+....+..+ ....++.+|-..+...... T Consensus 10 ~~~~~~p~~~d~~~KI~iiG~~~vGKSsLi~~l~~~~~~~~~~~t~~~~~~~~~~~~~-~~~v~~~i~D~~g~~~~~~-- 86 (189) T 2gf9_A 10 HSSGLVPRGSDYMFKLLLIGNSSVGKTSFLFRYADDSFTPAFVSTVGIDFKVKTVYRH-DKRIKLQIWDTAGQERYRT-- 86 (189) T ss_dssp ----CCCTTCSEEEEEEEECSTTSSHHHHHHHHHHSCCCCSCCCCCCCEEEEEEEEET-TEEEEEEEEECCSCCSSCC-- T ss_pred CCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCEECCCEEEEEEEC-CEEEEEEEECCCCCCHHHH-- T ss_conf 4568898886725899998179987899999986480364524210012102445421-1589998840677421345-- Q ss_pred HHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHH Q ss_conf 88771877878279998516663446899999999998640689987389984773456655324541157889999999 Q Fun_Sc_NP_0140 92 LKPFLQEHSSKVRWLILLDWTLNDQKLWLNELSYAFNKIKQLNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTL 171 (312) Q Consensus 92 Lkp~L~~~s~~~l~ViLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~L 171 (312) .....-..-..+++..|-+. +...-+.-..+.........+-+++||..|+| |.+++....++ + T Consensus 87 --~~~~~~~~~~~~iivfd~~~--~~S~~~~~~~~~~~~~~~~~~~piiivgnK~D----l~~~~~v~~~e--------~ 150 (189) T 2gf9_A 87 --ITTAYYRGAMGFLLMYDIAN--QESFAAVQDWATQIKTYSWDNAQVILVGNKCD----LEDERVVPAED--------G 150 (189) T ss_dssp --SGGGGGTTCSEEEEEEETTC--HHHHHTHHHHHHHHHHHSCTTCEEEEEEECTT----CGGGCCSCHHH--------H T ss_pred --HHHHHCCCCEEEEEEEECCC--CHHHHHHHHHHCCCCCCCCCCEEEEEECCCCC----CHHHHHHHHHH--------H T ss_conf --55876059718999985033--01233332100000102246624775013232----01232001789--------9 Q ss_pred HHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCC Q ss_conf 999988294158852565313555667788887530012477 Q Fun_Sc_NP_0140 172 RSFCYFNDSSLFYICEDHTEEKREEAQRLKYQELLKHFCEDR 213 (312) Q Consensus 172 RtvcL~yGASLiYts~ts~~~~kn~~~~l~y~~L~~h~l~~~ 213 (312) +.++-.+|...+.+ |+....+...++.. ++..+..+ T Consensus 151 ~~~a~~~~~~~~e~---Sa~~~~gI~elf~~---i~~~i~~~ 186 (189) T 2gf9_A 151 RRLADDLGFEFFEA---SAKENINVKQVFER---LVDVICEK 186 (189) T ss_dssp HHHHHHHTCEEEEC---BTTTTBSHHHHHHH---HHHHHHHH T ss_pred HHHHHHCCCCEEEE---ECCCCCCHHHHHHH---HHHHHHHH T ss_conf 99999659918999---62689788999999---99999998 No 48 >2nzj_A GTP-binding protein REM 1; GDP/GTP binding, GTP hydrolysis, RAD and GEM like GTP binding protein 1, structural genomics; HET: GDP; 2.50A {Homo sapiens} Probab=97.28 E-value=0.085 Score=33.05 Aligned_columns=160 Identities=9% Q ss_pred EEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCCCCEEEE Q ss_conf 89975983317999998514778655665575025633562121332688998607854358878877187787827999 Q Fun_Sc_NP_0140 28 AIIYSPSSKTLHQFINICFPEGSNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHSSKVRWLI 107 (312) Q Consensus 28 ~lilg~~~~~~~~fi~~l~~~~~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s~~~l~Vi 107 (312) ++++|....||++|++++......+..+..+.++....+.-+.++ +.+.+.+.+..+..+...+.-..-+.-.-+++ T Consensus 7 i~ivG~~~vGKSsLi~~~~~~~~~~~~~t~~~~~~~~~i~~~~~~---~~~~i~Dt~g~~~~~~~~~~~~~~~~~d~~il 83 (175) T 2nzj_A 7 VVLLGDPGVGKTSLASLFAGKQERDLHEQLGEDVYERTLTVDGED---TTLVVVDTWEAEKLDKSWSQESCLQGGSAYVI 83 (175) T ss_dssp EEEECCTTSSHHHHHHHHHCC-----CCCSSSSEEEEEEEETTEE---EEEEEECCC-------CHHHHHTTTSCSEEEE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCEE---EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH T ss_conf 989827998799999998557246653760443453003446536---77776212210134344333565432245444 Q ss_pred EECCCCCCHHHHHHHHHHHHHHHH--CCCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEE Q ss_conf 851666344689999999999864--068998738998477345665532454115788999999999998829415885 Q Fun_Sc_NP_0140 108 LLDWTLNDQKLWLNELSYAFNKIK--QLNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSLFYI 185 (312) Q Consensus 108 LLDWs~~Dp~~Wlr~Lr~~~~~L~--~l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGASLiYt 185 (312) +.|-+. +..+ ..+..|+..+. ......+++||..|+| |+...-.-.++. +.++..+|+..+-+ T Consensus 84 v~d~~~--~~s~-~~~~~~~~~~~~~~~~~~~~iilvgnK~D----l~~~~~v~~~~~--------~~~~~~~~~~~~e~ 148 (175) T 2nzj_A 84 VYSIAD--RGSF-ESASELRIQLRRTHQADHVPIILVGNKAD----LARCREVSVEEG--------RACAVVFDCKFIET 148 (175) T ss_dssp EEETTC--HHHH-HHHHHHHHHHHHC----CCCEEEEEECTT----CTTTCCSCHHHH--------HHHHHHHTSEEEEC T ss_pred HHHCCC--CCCC-HHHHHHHHHHHHHCCCCCEEEEEEECCCC----HHHHHCCCHHHH--------HHHHHHCCCCEEEE T ss_conf 431112--3430-03567778876312577427999814766----112204417788--------88999749818998 Q ss_pred CCCCCHHHHHHHHHHHHHHHHHHCCC Q ss_conf 25653135556677888875300124 Q Fun_Sc_NP_0140 186 CEDHTEEKREEAQRLKYQELLKHFCE 211 (312) Q Consensus 186 s~ts~~~~kn~~~~l~y~~L~~h~l~ 211 (312) |++...|-..++.. ++..++ T Consensus 149 ---Sa~~~~~i~~~f~~---l~~~i~ 168 (175) T 2nzj_A 149 ---SATLQHNVAELFEG---VVRQLR 168 (175) T ss_dssp ---BTTTTBSHHHHHHH---HHHHHH T ss_pred ---ECCCCCCHHHHHHH---HHHHHH T ss_conf ---62588788899999---999999 No 49 >e1z06a1 c.37.1.8 (A:32-196) Rab-33b {Mouse (Mus musculus) [TaxID:10090]} Probab=97.28 E-value=0.03 Score=35.74 Aligned_columns=154 Identities=12% Q ss_pred EEEECCCCHHHHHHHHHHCCCC-CCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCC-CCCEE Q ss_conf 8997598331799999851477-865566557502563356212133268899860785435887887718778-78279 Q Fun_Sc_NP_0140 28 AIIYSPSSKTLHQFINICFPEG-SNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHS-SKVRW 105 (312) Q Consensus 28 ~lilg~~~~~~~~fi~~l~~~~-~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s-~~~l~ 105 (312) ++++|..+.||++|++++.... .+.+.+..+.+|....+.-+ ....++.+|-..+...-. ..+.+.. .+.-. T Consensus 5 I~iiG~~~vGKTsli~~~~~~~~~~~~~~t~~~~~~~~~~~~~-~~~~~~~i~d~~~~~~~~-----~~~~~~~~~~~~~ 78 (165) T e1z06a1 5 IIVIGDSNVGKTCLTYRFCAGRFPDRTEATIGVDFRERAVDID-GERIKIQLWDTAGQERFR-----KSMVQHYYRNVHA 78 (165) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEECCCEEEEEEEC-CCEEEEEEEECCCCCCHH-----HHHHHHHHCCCCE T ss_conf 9998269987899999986382367624310000102676418-917999985035753012-----3431433014336 Q ss_pred EEEECCCCCCHHHHHHHHHHHHHHHHC--CCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEE Q ss_conf 998516663446899999999998640--689987389984773456655324541157889999999999988294158 Q Fun_Sc_NP_0140 106 LILLDWTLNDQKLWLNELSYAFNKIKQ--LNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSLF 183 (312) Q Consensus 106 ViLLDWs~~Dp~~Wlr~Lr~~~~~L~~--l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGASLi 183 (312) ++++-... |+.++-. +.+|+..++. ...+-+++||..|+|- .++-..-.+-++.++-.+|+..+ T Consensus 79 ~ilv~d~~-~~~s~~~-i~~~~~~i~~~~~~~~~piiivgnK~Dl------------~~~~~v~~~~~~~~~~~~~~~~~ 144 (165) T e1z06a1 79 VVFVYDMT-NMASFHS-LPAWIEECKQHLLANDIPRILVGNKCDL------------RSAIQVPTDLAQKFADTHSMPLF 144 (165) T ss_pred EEEEEECC-CCCCHHH-HHHHHHHHHHHHCCCCCCEEEEEECCCC------------HHCCCCCHHHHHHHHHHCCCCEE T ss_conf 89987505-6565678-9889999998603478838999715684------------00046798999999996599499 Q ss_pred EECCCCCHHHHHHHHHHH Q ss_conf 852565313555667788 Q Fun_Sc_NP_0140 184 YICEDHTEEKREEAQRLK 201 (312) Q Consensus 184 Yts~ts~~~~kn~~~~l~ 201 (312) .+|--.+....|-.-.+. T Consensus 145 e~SAK~~~~~~nv~~~f~ 162 (165) T e1z06a1 145 ETSAKNPNDNDHVEAIFM 162 (165) T ss_pred EEECCCCCCCCCHHHHHH T ss_conf 985377877747789998 No 50 >d1wmsa_ c.37.1.8 (A:) Rab9a {Human (Homo sapiens)} Probab=97.28 E-value=0.13 Score=31.92 Aligned_columns=152 Identities=9% Q ss_pred EEEECCCCHHHHHHHHHHCCCC-CCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCCCCEEE Q ss_conf 8997598331799999851477-865566557502563356212133268899860785435887887718778782799 Q Fun_Sc_NP_0140 28 AIIYSPSSKTLHQFINICFPEG-SNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHSSKVRWL 106 (312) Q Consensus 28 ~lilg~~~~~~~~fi~~l~~~~-~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s~~~l~V 106 (312) ++|+|....||++|++++..+. .+.+.++.+..|....+.-+ ....++.+|-..+...........+-.++ .++ T Consensus 9 ivivG~~~vGKTsLi~~~~~~~~~~~~~~t~~~~~~~~~i~~~-~~~i~l~~~d~~~~~~~~~~~~~~~~~~d----~~i 83 (174) T d1wmsa_ 9 VILLGDGGVGKSSLMNRYVTNKFDTQLFHTIGVEFLNKDLEVD-GHFVTMQIWDTAGQERFRSLRTPFYRGSD----CCL 83 (174) T ss_dssp EEEECCTTSSHHHHHHHHHHSCCCC----CCSEEEEEEEEEET-TEEEEEEEEECCCCGGGHHHHGGGGTTCS----EEE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEECEEEEEEEEC-CEEEEEEEEECCCCCHHHHHHHEECCCCE----EEE T ss_conf 9998179987899999986381356533315511056799998-97999998312473001021100126865----899 Q ss_pred EEECCCCCCHHHHHHHHHHHHHHHHCC-----CCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCE Q ss_conf 985166634468999999999986406-----899873899847734566553245411578899999999999882941 Q Fun_Sc_NP_0140 107 ILLDWTLNDQKLWLNELSYAFNKIKQL-----NDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSS 181 (312) Q Consensus 107 iLLDWs~~Dp~~Wlr~Lr~~~~~L~~l-----~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGAS 181 (312) ++.|-+. +++.-+ +..|...+++. ..+.++++|+.|+| |+.+. ...++ ++.++-++|.. T Consensus 84 ~v~d~~~--~~s~~~-i~~~~~~i~~~~~~~~~~~~piiivgnK~D----l~~~~--v~~ee-------~~~~~~~~~~~ 147 (174) T d1wmsa_ 84 LTFSVDD--SQSFQN-LSNWKKEFIYYADVKEPESFPFVILGNKID----ISERQ--VSTEE-------AQAWCRDNGDY 147 (174) T ss_dssp EEEETTC--HHHHHT-HHHHHHHHHHHHTCSCTTTSCEEEEEECTT----CSSCS--SCHHH-------HHHHHHHTTCC T ss_pred EEEECCC--HHHHHH-HHHHHHHHHHHHCCCCCCCCCEEEEECCCC----CCCCC--CCHHH-------HHHHHHHCCCC T ss_conf 9863588--678999-989999999871003678852899951457----54355--69899-------99999970798 Q ss_pred EEEECCCCCHHHHHHHHHHHH Q ss_conf 588525653135556677888 Q Fun_Sc_NP_0140 182 LFYICEDHTEEKREEAQRLKY 202 (312) Q Consensus 182 LiYts~ts~~~~kn~~~~l~y 202 (312) .+|- +|++...|-...+.. T Consensus 148 ~~~e--~Sak~~~~I~e~f~~ 166 (174) T d1wmsa_ 148 PYFE--TSAKDATNVAAAFEE 166 (174) T ss_dssp CEEE--CCTTTCTTHHHHHHH T ss_pred CEEE--EECCCCCCHHHHHHH T ss_conf 2799--860589888899999 No 51 >e1z0fa_ c.37.1.8 (A:) Rab14 {Human (Homo sapiens) [TaxID:9606]} SCOP: u2aeda1 Probab=97.27 E-value=0.052 Score=34.33 Aligned_columns=159 Identities=9% Q ss_pred EEEECCCCHHHHHHHHHHCCCC-CCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCCCCEEE Q ss_conf 8997598331799999851477-865566557502563356212133268899860785435887887718778782799 Q Fun_Sc_NP_0140 28 AIIYSPSSKTLHQFINICFPEG-SNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHSSKVRWL 106 (312) Q Consensus 28 ~lilg~~~~~~~~fi~~l~~~~-~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s~~~l~V 106 (312) ++++|....||++|++++.... .+.+.++.+.++....+.-+ ....++..|-..+.-.... .....-..-..++ T Consensus 8 i~ivG~~~vGKTsLi~~~~~~~~~~~~~~t~~~~~~~~~~~~~-~~~~~i~i~d~~g~~~~~~----~~~~~~~~~d~~i 82 (167) T e1z0fa_ 8 YIIIGDMGVGKSCLLHQFTEKKFMADCPHTIGVEFGTRIIEVS-GQKIKLQIWDTAGQERFRA----VTRSYYRGAAGAL 82 (167) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEEEC-CCEEEEEEECCCCCCHHHH----HHHHHCCCCCEEE T ss_conf 9998179977999999986482356654124433201689877-9325787721677301212----1032236886799 Q ss_pred EEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEC Q ss_conf 98516663446899999999998640689987389984773456655324541157889999999999988294158852 Q Fun_Sc_NP_0140 107 ILLDWTLNDQKLWLNELSYAFNKIKQLNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSLFYIC 186 (312) Q Consensus 107 iLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGASLiYts 186 (312) ++.|-+ |+..+-.....+-...+....+.+++||+.|+| |++.. +-..+-++.++-.+|+..+.+ T Consensus 83 ~v~d~~--~~~s~~~~~~~~~~~~~~~~~~~~iiiv~nK~D----l~~~~--------~i~~~e~~~~~~~~~~~~~e~- 147 (167) T e1z0fa_ 83 MVYDIT--RRSTYNHLSSWLTDARNLTNPNTVIILIGNKAD----LEAQR--------DVTYEEAKQFAEENGLLFLEA- 147 (167) T ss_pred EEEECC--CCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCH----HHHCC--------CCCHHHHHHHHHHCCCEEEEE- T ss_conf 998527--740289999888889886178725887521102----10002--------431789999999649829999- Q ss_pred CCCCHHHHHHHHHHHHHHHHHHCCC Q ss_conf 5653135556677888875300124 Q Fun_Sc_NP_0140 187 EDHTEEKREEAQRLKYQELLKHFCE 211 (312) Q Consensus 187 ~ts~~~~kn~~~~l~y~~L~~h~l~ 211 (312) |++...|...++.. ++..+| T Consensus 148 --Sa~~g~gi~elf~~---i~~~iy 167 (167) T e1z0fa_ 148 --SAKTGENVEDAFLE---AAKKIY 167 (167) T ss_pred --ECCCCCCHHHHHHH---HHHHHC T ss_conf --62689888899999---999719 No 52 >e1yzqa1 c.37.1.8 (A:14-177) Rab6 {Human (Homo sapiens) [TaxID:9606]} SCOP: d1d5ca_ Probab=97.27 E-value=0.043 Score=34.80 Aligned_columns=160 Identities=8% Q ss_pred EEEECCCCHHHHHHHHHHCCCC-CCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCCCCEEE Q ss_conf 8997598331799999851477-865566557502563356212133268899860785435887887718778782799 Q Fun_Sc_NP_0140 28 AIIYSPSSKTLHQFINICFPEG-SNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHSSKVRWL 106 (312) Q Consensus 28 ~lilg~~~~~~~~fi~~l~~~~-~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s~~~l~V 106 (312) ++++|....||++|++++..+. .+.+....+.++....+.-+ .....+.+|-..|.-.........+-..+ .++ T Consensus 3 i~iiG~~~vGKSsli~~l~~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~i~D~~g~~~~~~~~~~~~~~~~----~~i 77 (164) T e1yzqa1 3 LVFLGEQSVGKTSLITRFMYDSFDNTYQATIGIDFLSKTMYLE-DRTIRLQLWDTAGQERFRSLIPSYIRDSA----AAV 77 (164) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEEEE-CEEEEEEEECCCCCHHHHHHHHHHHHCCC----EEE T ss_conf 8998179987999999986581256625531036788999970-42799998447772033344577740698----289 Q ss_pred EEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEC Q ss_conf 98516663446899999999998640689987389984773456655324541157889999999999988294158852 Q Fun_Sc_NP_0140 107 ILLDWTLNDQKLWLNELSYAFNKIKQLNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSLFYIC 186 (312) Q Consensus 107 iLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGASLiYts 186 (312) ++.|-+..+...++++....+.... ..+-++++|+.|+|-...-+-.. +-++.+|-.+|...+-+ T Consensus 78 ~v~d~~~~~s~~~~~~~~~~~~~~~--~~~~piiiv~nK~Dl~~~~~i~~------------~~~~~~~~~~~~~~~e~- 142 (164) T e1yzqa1 78 VVYDITNVNSFQQTTKWIDDVRTER--GSDVIIMLVGNKTDLADKRQVSI------------EEGERKAKELNVMFIET- 142 (164) T ss_pred EEEECCCCCCHHHHHHHHHHHHHHC--CCCEEEHHHEECCCCCCCCCCCH------------HHHHHHHHHCCCEEEEE- T ss_conf 9851333441777768889887640--78611012000113000466688------------89999999649818998- Q ss_pred CCCCHHHHHHHHHHHHHHHHHHCCCC Q ss_conf 56531355566778888753001247 Q Fun_Sc_NP_0140 187 EDHTEEKREEAQRLKYQELLKHFCED 212 (312) Q Consensus 187 ~ts~~~~kn~~~~l~y~~L~~h~l~~ 212 (312) |+++..|-..++.. ++..+.| T Consensus 143 --Sak~g~~i~e~f~~---Ia~~lp~ 163 (164) T e1yzqa1 143 --SAKAGYNVKQLFRR---VAAALPG 163 (164) T ss_pred --ECCCCCCHHHHHHH---HHHHCCC T ss_conf --62689788899999---9986468 No 53 >2atv_A RERG, RAS-like estrogen-regulated growth inhibitor; GDP/GTP binding, GTP hydrolysis, structural genomics, structural genomics consortium, SGC; HET: GDP; 1.90A {Homo sapiens} SCOP: c.37.1.8 Probab=97.26 E-value=0.088 Score=32.95 Aligned_columns=168 Identities=12% Q ss_pred CCCEEEEECCCCHHHHHHHHHHCCCC-CCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCCC Q ss_conf 64438997598331799999851477-86556655750256335621213326889986078543588788771877878 Q Fun_Sc_NP_0140 24 ATITAIIYSPSSKTLHQFINICFPEG-SNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHSSK 102 (312) Q Consensus 24 ~~k~~lilg~~~~~~~~fi~~l~~~~-~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s~~ 102 (312) .+..++++|..+.|||+|+.++..+. .+.+.++.+..|......++ ...++.+|-..+.... .....++-+++ T Consensus 27 ~eiKI~viG~~~vGKTsLi~~~~~~~~~~~~~~Ti~~~~~~~~~~~~--~~~~l~i~d~~g~~~~-~~~~~~~~~~d--- 100 (196) T 2atv_A 27 AEVKLAIFGRAGVGKSALVVRFLTKRFIWEYDPTLESTYRHQATIDD--EVVSMEILDTAGQEDT-IQREGHMRWGE--- 100 (196) T ss_dssp CCEEEEEECCTTSSHHHHHHHHHHSCCCSCCCTTCCEEEEEEEEETT--EEEEEEEEECCCCCCC-HHHHHHHHHCS--- T ss_pred CCEEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEECC--EEEEEEEECCCCCCHH-HHHHHHCCCCC--- T ss_conf 75379998079977899999986381576545310036889888615--6888877404443201-22012003560--- Q ss_pred CEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEE Q ss_conf 27999851666344689999999999864068998738998477345665532454115788999999999998829415 Q Fun_Sc_NP_0140 103 VRWLILLDWTLNDQKLWLNELSYAFNKIKQLNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSL 182 (312) Q Consensus 103 ~l~ViLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGASL 182 (312) -++++.|-+..+....+..+...+...+... +.++++|+.|+| |+.+.....++ .+.+|=.+|+.. T Consensus 101 -~~ilvfD~~~~~S~~~~~~~~~~~~~~~~~~-~~piilVgnK~D----l~~~r~i~~~e--------~~~~a~~~~~~~ 166 (196) T 2atv_A 101 -GFVLVYDITDRGSFEEVLPLKNILDEIKKPK-NVTLILVGNKAD----LDHSRQVSTEE--------GEKLATELACAF 166 (196) T ss_dssp -EEEEEEETTCHHHHHTHHHHHHHHHHHHTTS-CCCEEEEEECGG----GGGGCCSCHHH--------HHHHHHHHTSEE T ss_pred -EEEEEEEECCCCCHHHHHHHHHCCCCCCCCC-CCEEEEEECCCC----CCHHCCCCHHH--------HHHHHHHCCCCE T ss_conf -4789998504546224555531011223678-861899952534----10011677889--------999999649948 Q ss_pred EEECCCCCHHHH-HHHHHHHHHHHHHHCCCCCCCCC Q ss_conf 885256531355-56677888875300124778775 Q Fun_Sc_NP_0140 183 FYICEDHTEEKR-EEAQRLKYQELLKHFCEDRDMKD 217 (312) Q Consensus 183 iYts~ts~~~~k-n~~~~l~y~~L~~h~l~~~~~~~ 217 (312) |-+ |+++.. |-...+.. +++.+..+.... T Consensus 167 ~e~---Sak~g~~nV~e~f~~---l~~~i~~~~~~q 196 (196) T 2atv_A 167 YEC---SACTGEGNITEIFYE---LCREVRRRRMVQ 196 (196) T ss_dssp EEC---CTTTCTTCHHHHHHH---HHHHHHHHHC-- T ss_pred EEE---EECCCCCCHHHHHHH---HHHHHHHHCCCC T ss_conf 999---720588247889999---999999710369 No 54 >cd01868 Rab11_like Rab11-like. Rab11a, Rab11b, and Rab25 are closely related, evolutionary conserved Rab proteins that are differentially expressed. Rab11a is ubiquitously synthesized, Rab11b is enriched in brain and heart and Rab25 is only found in epithelia. Rab11/25 proteins seem to regulate recycling pathways from endosomes to the plasma membrane and to the trans-Golgi network. Furthermore, Rab11a is thought to function in the histamine-induced fusion of tubulovesicles containing H+, K+ ATPase with the plasma membrane in gastric parietal cells and in insulin-stimulated insertion of GLUT4 in the plasma membrane of cardiomyocytes. Overexpression of Rab25 has recently been observed in ovarian cancer and breast cancer, and has been correlated with worsened outcomes in both diseases. In addition, Rab25 overexpression has also been observed in prostate cancer, transitional cell carcinoma of the bladder, and invasive breast tumor cells. GTPase activating proteins (GAPs) interact with GTP Probab=97.23 E-value=0.14 Score=31.84 Aligned_columns=158 Identities=11% Q ss_pred EEEECCCCHHHHHHHHHHCCCC-CCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCCCCEEE Q ss_conf 8997598331799999851477-865566557502563356212133268899860785435887887718778782799 Q Fun_Sc_NP_0140 28 AIIYSPSSKTLHQFINICFPEG-SNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHSSKVRWL 106 (312) Q Consensus 28 ~lilg~~~~~~~~fi~~l~~~~-~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s~~~l~V 106 (312) ++++|..+.|||+|+.+..... .+.+.+..|.++....+ ..++..+.+-+.+.+..+.-..+.+..=..+.-..+| T Consensus 6 i~~iG~~~VGKTsli~r~~~~~F~~~~~~Tig~~~~~k~v---~~~~~~~~l~iwDtaG~e~~~~~~~~~~~~a~~~iiv 82 (165) T cd01868 6 IVLIGDSGVGKSNLLSRFTRNEFNLDSKSTIGVEFATRSI---QIDGKTIKAQIWDTAGQERYRAITSAYYRGAVGALLV 82 (165) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEE---EECCEEEEEEEECCCCCHHHHHHHHHHHCCCCEEEEE T ss_conf 9998269965899999986385674556410012468898---6489089999853898612457767650488679999 Q ss_pred EEECCCCCCHHHHHHHHHHHHHHHHCCCCCC-CEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEE Q ss_conf 9851666344689999999999864068998-738998477345665532454115788999999999998829415885 Q Fun_Sc_NP_0140 107 ILLDWTLNDQKLWLNELSYAFNKIKQLNDDN-EFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSLFYI 185 (312) Q Consensus 107 iLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~Dt-~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGASLiYt 185 (312) + |-+. +..+.+- ..|+..++...... ++++|..|+| |+..+-.-.++.-+|..+ +|+..+-| T Consensus 83 y--Dit~--~~Sf~~i-~~w~~~i~~~~~~~~piilVGNK~D----L~~~r~v~~~e~~~~a~~--------~~~~~~e~ 145 (165) T cd01868 83 Y--DITK--KQTFENV-ERWLKELRDHADSNIVIMLVGNKSD----LRHLRAVPTEEAKAFAEK--------NGLSFIET 145 (165) T ss_pred E--ECCC--HHHHHHH-HHHHHHHHHHCCCCCEEEEEECCCC----HHHCCCCCHHHHHHHHHH--------CCCCEEEE T ss_conf 7--4699--7789999-9999999983289937999821656----212037768899999996--------59949999 Q ss_pred CCCCCHHHHHHHHHHHHHHHHHHCCC Q ss_conf 25653135556677888875300124 Q Fun_Sc_NP_0140 186 CEDHTEEKREEAQRLKYQELLKHFCE 211 (312) Q Consensus 186 s~ts~~~~kn~~~~l~y~~L~~h~l~ 211 (312) |+++..|-...+.. ++-.++ T Consensus 146 ---Sak~g~ni~~~F~~---l~~~i~ 165 (165) T cd01868 146 ---SALDGTNVEEAFKQ---LLTEIY 165 (165) T ss_pred ---ECCCCCCHHHHHHH---HHHHCC T ss_conf ---71479888899999---998709 No 55 >cd00876 Ras Ras family. The Ras family of the Ras superfamily includes classical N-Ras, H-Ras, and K-Ras, as well as R-Ras, Rap, Ral, Rheb, Rhes, ARHI, RERG, Rin/Rit, RSR1, RRP22, Ras2, Ras-dva, and RGK proteins. Ras proteins regulate cell growth, proliferation and differentiation. Ras is activated by guanine nucleotide exchange factors (GEFs) that release GDP and allow GTP binding. Many RasGEFs have been identified. These are sequestered in the cytosol until activation by growth factors triggers recruitment to the plasma membrane or Golgi, where the GEF colocalizes with Ras. Active GTP-bound Ras interacts with several effector proteins: among the best characterized are the Raf kinases, phosphatidylinositol 3-kinase (PI3K), RalGEFs and NORE/MST1. Most Ras proteins contain a lipid modification site at the C-terminus, with a typical sequence motif CaaX, where a = an aliphatic amino acid and X = any amino acid. Lipid binding is essential for membrane attachment, a key feature of m Probab=97.23 E-value=0.097 Score=32.70 Aligned_columns=151 Identities=9% Q ss_pred EEEECCCCHHHHHHHHHHCCCCCCCCCCCCC-CEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCCCCEEE Q ss_conf 8997598331799999851477865566557-502563356212133268899860785435887887718778782799 Q Fun_Sc_NP_0140 28 AIIYSPSSKTLHQFINICFPEGSNSILDTTL-INYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHSSKVRWL 106 (312) Q Consensus 28 ~lilg~~~~~~~~fi~~l~~~~~e~~~~~~~-L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s~~~l~V 106 (312) ++++|+.+.|||+|+.+. -+.+++.+..+ ++-+|.-...-...+.++.+|=..| ...+..+.+..+ +.-..++ T Consensus 2 i~~iGd~~vGKTsli~r~--~~~~f~~~~~~ti~~~~~k~~~~~~~~~~l~i~Dt~G-~e~~~~~~~~~~---~~a~~~i 75 (160) T cd00876 2 VVVLGAGGVGKSAITIQF--VKGTFVEEYDPTIEDSYRKTIVVDGETYTLDILDTAG-QEEFSAMRDLYI---RQGDGFI 75 (160) T ss_pred EEEEECCCCCHHHHHHHH--HCCCCCCCCCCCHHHEEEEEEEECCEEEEEEEEECCC-CHHHHHHHHHHH---CCCCEEE T ss_conf 788807996689999998--7281067535420022677888848289999863588-413346888764---0461789 Q ss_pred EEECCCCCCHHHHHHHHHHHHHHHHC--CCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEE Q ss_conf 98516663446899999999998640--6899873899847734566553245411578899999999999882941588 Q Fun_Sc_NP_0140 107 ILLDWTLNDQKLWLNELSYAFNKIKQ--LNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSLFY 184 (312) Q Consensus 107 iLLDWs~~Dp~~Wlr~Lr~~~~~L~~--l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGASLiY 184 (312) +.-|=+. +..+ ..+..|+..+++ .....++++|..|+| |..++-...++ .+.++-++|+..+- T Consensus 76 ivfdi~~--~~Sf-~~i~~w~~~i~~~~~~~~~piilvgNK~D----l~~~r~v~~~e--------~~~~a~~~~~~~~e 140 (160) T cd00876 76 LVYSITD--RESF-EEIKGYREQILRVKDDEDIPIVLVGNKCD----LENERQVSKEE--------GKALAKEWGCPFIE 140 (160) T ss_pred EEEECCC--HHHH-HHHHHHHHHHHHHCCCCCCEEEEEECCCC----CHHHCCCCHHH--------HHHHHHHCCCCEEE T ss_conf 9986699--7799-99999999999853899967999821326----30011676889--------99999964996999 Q ss_pred ECCCCCHHHHHHHHHHHH Q ss_conf 525653135556677888 Q Fun_Sc_NP_0140 185 ICEDHTEEKREEAQRLKY 202 (312) Q Consensus 185 ts~ts~~~~kn~~~~l~y 202 (312) | |+++..|-..++.. T Consensus 141 ~---Sak~~~nV~~~F~~ 155 (160) T cd00876 141 T---SAKDNINIDEVFKL 155 (160) T ss_pred E---EECCCCCHHHHHHH T ss_conf 9---70489888899999 No 56 >e2erxa1 c.37.1.8 (A:6-176) di-Ras2 {Human (Homo sapiens) [TaxID:9606]} SCOP: u2erxb_ u2gf0c_ u2gf0d_ u2gf0a1 u2gf0b_ Probab=97.22 E-value=0.091 Score=32.88 Aligned_columns=165 Identities=7% Q ss_pred EEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCC-EEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCC-CCCE Q ss_conf 389975983317999998514778655665575-02563356212133268899860785435887887718778-7827 Q Fun_Sc_NP_0140 27 TAIIYSPSSKTLHQFINICFPEGSNSILDTTLI-NYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHS-SKVR 104 (312) Q Consensus 27 ~~lilg~~~~~~~~fi~~l~~~~~e~~~~~~~L-~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s-~~~l 104 (312) .++++|+.+.|||+|++++ -+...+....+- +-.|.....-.....++..|-..|.-... ......- .-.. T Consensus 4 kI~vvG~~~vGKTsli~~~--~~~~~~~~~~~t~~~~~~~~~~~~~~~~~~~i~d~~g~~~~~-----~~~~~~~~~~~~ 76 (171) T e2erxa1 4 RVAVFGAGGVGKSSLVLRF--VKGTFRESYIPTVEDTYRQVISCDKSICTLQITDTTGSHQFP-----AMQRLSISKGHA 76 (171) T ss_pred EEEEEECCCCCHHHHHHHH--HCCCCCCCCCCEEEEEEEEEEEECCEEEEEEEEECCCCHHHH-----HHHHHHCCCCCE T ss_conf 8999807998799999998--638216662430220025799874647899997305610233-----430221158726 Q ss_pred EEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEE Q ss_conf 99985166634468999999999986406899873899847734566553245411578899999999999882941588 Q Fun_Sc_NP_0140 105 WLILLDWTLNDQKLWLNELSYAFNKIKQLNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSLFY 184 (312) Q Consensus 105 ~ViLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGASLiY 184 (312) ++++.|-+..+..-++....+++...+......+++|++.|+| |..+. ....++. +.++-.+|+..+. T Consensus 77 ~i~v~d~~~~~s~~~~~~~~~~l~~~~~~~~~~piiivgnK~D----l~~~~-~i~~~~~-------~~~~~~~~~~~~~ 144 (171) T e2erxa1 77 FILVYSITSRQSLEELKPIYEQICEIKGDVESIPIMLVGNKCD----ESPSR-EVQSSEA-------EALARTWKCAFME 144 (171) T ss_pred EEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCC----CCCCC-CCCHHHH-------HHHHHHCCCCEEE T ss_conf 9999717742007899999754666402678852799973135----66333-5447899-------9999964992899 Q ss_pred ECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCC Q ss_conf 52565313555667788887530012477877 Q Fun_Sc_NP_0140 185 ICEDHTEEKREEAQRLKYQELLKHFCEDRDMK 216 (312) Q Consensus 185 ts~ts~~~~kn~~~~l~y~~L~~h~l~~~~~~ 216 (312) + |++...+-..++.- +++....+... T Consensus 145 ~---Sak~g~gi~e~f~~---i~~~~~~~~~~ 170 (171) T e2erxa1 145 T---SAKLNHNVKELFQE---LLNLEKRRTVS 170 (171) T ss_pred E---ECCCCCCHHHHHHH---HHHHHHHCCCC T ss_conf 9---70589687899999---99999841247 No 57 >2erx_A GTP-binding protein DI-RAS2; GTP hydrolysis; HET: GDP; 1.65A {Homo sapiens} SCOP: c.37.1.8 Probab=97.22 E-value=0.11 Score=32.46 Aligned_columns=163 Identities=8% Q ss_pred EEEECCCCHHHHHHHHHHCCCC-CCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCCCCEEE Q ss_conf 8997598331799999851477-865566557502563356212133268899860785435887887718778782799 Q Fun_Sc_NP_0140 28 AIIYSPSSKTLHQFINICFPEG-SNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHSSKVRWL 106 (312) Q Consensus 28 ~lilg~~~~~~~~fi~~l~~~~-~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s~~~l~V 106 (312) ++++|..+.|||+|++++.... .+.+....+..|.... ..|+..+.+.+.+.+..+..+.+.... -..-..++ T Consensus 6 I~lvG~~~~GKTsll~~l~~~~~~~~~~~t~~~~~~~~~----~~~~~~~~l~i~d~~g~e~~~~~~~~~--~~~~~~~i 79 (172) T 2erx_A 6 VAVFGAGGVGKSSLVLRFVKGTFRESYIPTVEDTYRQVI----SCDKSICTLQITDTTGSHQFPAMQRLS--ISKGHAFI 79 (172) T ss_dssp EEEECCTTSSHHHHHHHHHTCCCCSSCCCCSCEEEEEEE----EETTEEEEEEEEECCSCSSCHHHHHHH--HHHCSEEE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEE----EECCEEEEEEEEECCCCCCCCCCCCHH--CCCCCEEE T ss_conf 999807998799999998638326762430320145788----536735665433111101221001000--02200012 Q ss_pred EEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEC Q ss_conf 98516663446899999999998640689987389984773456655324541157889999999999988294158852 Q Fun_Sc_NP_0140 107 ILLDWTLNDQKLWLNELSYAFNKIKQLNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSLFYIC 186 (312) Q Consensus 107 iLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGASLiYts 186 (312) ++.|-+..+..-+++.+...+..++....+.+++++..|+|-...-+-.. +-.+.++-.+|+..+-+ T Consensus 80 ~v~d~~~~~s~~~~~~~~~~~~~~~~~~~~~piiii~nK~Dl~~~~~v~~------------~~~~~~~~~~~~~~~e~- 146 (172) T 2erx_A 80 LVYSITSRQSLEELKPIYEQICEIKGDVESIPIMLVGNKCDESPSREVQS------------SEAEALARTWKCAFMET- 146 (172) T ss_dssp EEEETTCHHHHHTTHHHHHHHHHHHC---CCCEEEEEECGGGGGGCCSCH------------HHHHHHHHHHTCEEEEC- T ss_pred EEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHH------------HHHHHHHHHCCCCEEEE- T ss_conf 10000134441257899998752011236863013343667630000028------------99999999649828998- Q ss_pred CCCCHHHHHHHHHHHHHHHHHHCCCCCC Q ss_conf 5653135556677888875300124778 Q Fun_Sc_NP_0140 187 EDHTEEKREEAQRLKYQELLKHFCEDRD 214 (312) Q Consensus 187 ~ts~~~~kn~~~~l~y~~L~~h~l~~~~ 214 (312) |++...+...++.. +++....+. T Consensus 147 --Sak~~~gi~e~f~~---ii~l~~~~~ 169 (172) T 2erx_A 147 --SAKLNHNVKELFQE---LLNLEKRRT 169 (172) T ss_dssp --BTTTTBSHHHHHHH---HHHTCCSSC T ss_pred --ECCCCCCHHHHHHH---HHHHHHHHH T ss_conf --61588687899999---999998400 No 58 >e2g6ba1 c.37.1.8 (A:58-227) Rab26 {Human (Homo sapiens) [TaxID:9606]} Probab=97.21 E-value=0.035 Score=35.35 Aligned_columns=157 Identities=5% Q ss_pred EEEECCCCHHHHHHHHHHCCCC--CCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCCCCEE Q ss_conf 8997598331799999851477--86556655750256335621213326889986078543588788771877878279 Q Fun_Sc_NP_0140 28 AIIYSPSSKTLHQFINICFPEG--SNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHSSKVRW 105 (312) Q Consensus 28 ~lilg~~~~~~~~fi~~l~~~~--~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s~~~l~ 105 (312) ++++|+.+.|||+||.++.... ......+.+..+....+..+ ....++..|-..|.-.. ..+....-...- T Consensus 9 i~ivG~~~vGKTsli~~l~~~~~~~~~~~~t~~~~~~~~~~~~~-~~~~~l~i~D~~g~~~~------~~~~~~~~~~~~ 81 (170) T e2g6ba1 9 VMLVGDSGVGKTCLLVRFKDGAFLAGTFISTVGIDFRNKVLDVD-GVKVKLQMWDTAGQERF------RSVTHAYYRDAH 81 (170) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEEEC-CEEEEEEEEECCCCCHH------HHHHHHHHCCCC T ss_conf 99982699778999999864832677424301001015789888-97899999734784101------121044525871 Q ss_pred EEEECCCCCCHHHHHHHHHHHHHHHHCCCCC-CCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEE Q ss_conf 9985166634468999999999986406899-873899847734566553245411578899999999999882941588 Q Fun_Sc_NP_0140 106 LILLDWTLNDQKLWLNELSYAFNKIKQLNDD-NEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSLFY 184 (312) Q Consensus 106 ViLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~D-t~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGASLiY 184 (312) ++++-++..++..+ ..++.|+..++....+ -++++|+.|+|....-+-.. +-++.++-++|+..+. T Consensus 82 ~~i~v~d~~~~~s~-~~~~~~~~~i~~~~~~~~p~iiv~nK~Dl~~~~~v~~------------~~~~~~~~~~~~~~~e 148 (170) T e2g6ba1 82 ALLLLYDVTNKASF-DNIQAWLTEIHEYAQHDVALMLLGNKVDSAHERVVKR------------EDGEKLAKEYGLPFME 148 (170) T ss_pred EEEEEEECCCHHHH-HHHHHHHHHHHHCCCCCCEEEEEEECCCHHHHCCCCH------------HHHHHHHHHCCCCEEE T ss_conf 78998505520358-8761115788621588705775321000001015577------------8999999965992899 Q ss_pred ECCCCCHHHHHHHHHHHHHHHHHHCC Q ss_conf 52565313555667788887530012 Q Fun_Sc_NP_0140 185 ICEDHTEEKREEAQRLKYQELLKHFC 210 (312) Q Consensus 185 ts~ts~~~~kn~~~~l~y~~L~~h~l 210 (312) + |++...|-..++.. ++..+ T Consensus 149 ~---Sak~g~gI~elf~~---i~~~i 168 (170) T e2g6ba1 149 T---SAKTGLNVDLAFTA---IAKEL 168 (170) T ss_pred E---ECCCCCCHHHHHHH---HHHHH T ss_conf 9---72689888899999---99995 No 59 >1r2q_A RAS-related protein RAB-5A; GTPase, GNP, atomic resolution; HET: GNP; 1.05A {Homo sapiens} SCOP: c.37.1.8 Probab=97.20 E-value=0.4 Score=29.08 Aligned_columns=168 Identities=7% Q ss_pred CCCCCCCEEEEECCCCHHHHHHHHHHCC-CCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCC Q ss_conf 5536644389975983317999998514-778655665575025633562121332688998607854358878877187 Q Fun_Sc_NP_0140 20 STETATITAIIYSPSSKTLHQFINICFP-EGSNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQE 98 (312) Q Consensus 20 ~k~~~~k~~lilg~~~~~~~~fi~~l~~-~~~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~ 98 (312) |.....-.++++|+.+.||++|+.++.. +-.+...+..+..+....+... ....++..|--.|.-....-.-..+ T Consensus 1 ~~~~~~yKv~viG~~~vGKTsLi~~~~~~~~~~~~~~t~~~~~~~~~~~~~-~~~~~l~i~d~~g~~~~~~~~~~~~--- 76 (170) T 1r2q_A 1 GNKICQFKLVLLGESAVGKSSLVLRFVKGQFHEFQESTIGAAFLTQTVCLD-DTTVKFEIWDTAGQERYHSLAPMYY--- 76 (170) T ss_dssp CCEEEEEEEEEECSTTSSHHHHHHHHHHSCCCTTCCCCSSEEEEEEEEEET-TEEEEEEEEEECCSGGGGGGHHHHH--- T ss_pred CCCCCEEEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCC-CCEEEEEEECCCCCCHHHHHHHHHH--- T ss_conf 986403789998179977899999986480155435400111001221478-8468998721556320113326752--- Q ss_pred CCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHC Q ss_conf 78782799985166634468999999999986406899873899847734566553245411578899999999999882 Q Fun_Sc_NP_0140 99 HSSKVRWLILLDWTLNDQKLWLNELSYAFNKIKQLNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFN 178 (312) Q Consensus 99 ~s~~~l~ViLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~y 178 (312) +.-..+++..|-+ |+...-.....+-...+....+.++++|..|+|....-+-.. +-++.+|-.+ T Consensus 77 -~~~~~~i~v~d~~--~~~s~~~~~~~~~~i~~~~~~~~piilvgnK~Dl~~~~~v~~------------~~~~~~a~~~ 141 (170) T 1r2q_A 77 -RGAQAAIVVYDIT--NEESFARAKNWVKELQRQASPNIVIALSGNKADLANKRAVDF------------QEAQSYADDN 141 (170) T ss_dssp -TTCSEEEEEEETT--CHHHHHHHHHHHHHHHHHSCTTCEEEEEEECGGGGGGCCSCH------------HHHHHHHHHT T ss_pred -CCCCEEEEEEECC--CCCCCHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHH------------HHHHHHHHHC T ss_conf -3775489984055--553430144556655332037822441346430133431024------------4443578865 Q ss_pred CCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCC Q ss_conf 9415885256531355566778888753001247 Q Fun_Sc_NP_0140 179 DSSLFYICEDHTEEKREEAQRLKYQELLKHFCED 212 (312) Q Consensus 179 GASLiYts~ts~~~~kn~~~~l~y~~L~~h~l~~ 212 (312) |+..+.+ |++...+...++.. ++..+.. T Consensus 142 ~~~~~~~---Sak~g~~i~elf~~---l~~~i~~ 169 (170) T 1r2q_A 142 SLLFMET---SAKTSMNVNEIFMA---IAKKLPK 169 (170) T ss_dssp TCEEEEC---CTTTCTTHHHHHHH---HHHTSCC T ss_pred CCEEEEE---ECCCCCCHHHHHHH---HHHHHHC T ss_conf 9628998---62789788899999---9999622 No 60 >1yzq_A Small GTP binding protein RAB6 isoform; RAB GTPase, vesicular trafficking, protein transport; HET: GNP; 1.78A {Homo sapiens} SCOP: c.37.1.8 Probab=97.20 E-value=0.26 Score=30.20 Aligned_columns=168 Identities=9% Q ss_pred CCCCCCCEEEEECCCCHHHHHHHHHHCCCC-CCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCC Q ss_conf 553664438997598331799999851477-8655665575025633562121332688998607854358878877187 Q Fun_Sc_NP_0140 20 STETATITAIIYSPSSKTLHQFINICFPEG-SNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQE 98 (312) Q Consensus 20 ~k~~~~k~~lilg~~~~~~~~fi~~l~~~~-~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~ 98 (312) |.-...-.++++|....||++|+.++.... .+.+....+.+|....+..+ .....+..|-..+...........+.+. T Consensus 1 ~~p~~~~kI~iiG~~~vGKTsli~~~~~~~~~~~~~~t~~~~~~~~~~~~~-~~~~~l~~~d~~g~~~~~~~~~~~~~~~ 79 (170) T 1yzq_A 1 GSPLRKFKLVFLGEQSVGKTSLITRFMYDSFDNTYQATIGIDFLSKTMYLE-DRTIRLQLWDTAGQERFRSLIPSYIRDS 79 (170) T ss_dssp ------CEEEEEESTTSSHHHHHHHHHHSCCCSSCCCCCSEEEEEEEEECS-SCEEEEEEEEECCSGGGGGGHHHHHTTC T ss_pred CCCCCEEEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEECC-CCEEEEEECCCCCCCHHCCCCHHHHCCC T ss_conf 997614789998079977899999986482455544210003433576115-8467664314655210012330010001 Q ss_pred CCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHC Q ss_conf 78782799985166634468999999999986406899873899847734566553245411578899999999999882 Q Fun_Sc_NP_0140 99 HSSKVRWLILLDWTLNDQKLWLNELSYAFNKIKQLNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFN 178 (312) Q Consensus 99 ~s~~~l~ViLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~y 178 (312) ..++++.|-+. +...-..-+.+-........+.++++|+.|+|-...-+... +.++.++-.+ T Consensus 80 ----~~~i~v~d~~~--~~s~~~i~~~~~~~~~~~~~~~p~ilV~nK~Dl~~~~~~~~------------~~~~~~~~~~ 141 (170) T 1yzq_A 80 ----AAAVVVYDITN--VNSFQQTTKWIDDVRTERGSDVIIMLVGNKTDLADKRQVSI------------EEGERKAKEL 141 (170) T ss_dssp ----SEEEEEEETTC--HHHHHTHHHHHHHHHHHHTTSSEEEEEEECTTCGGGCCSCH------------HHHHHHHHHT T ss_pred ----EEEEEEECCCC--HHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHH------------HHHHHHHHHC T ss_conf ----13466431566--02455555655433221147841799862558123332468------------9999999964 Q ss_pred CCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCC Q ss_conf 9415885256531355566778888753001247 Q Fun_Sc_NP_0140 179 DSSLFYICEDHTEEKREEAQRLKYQELLKHFCED 212 (312) Q Consensus 179 GASLiYts~ts~~~~kn~~~~l~y~~L~~h~l~~ 212 (312) |...|-+ |+++..+-..++.. ++..+.+ T Consensus 142 ~~~~~ev---Sa~~~~gv~~~f~~---i~~~l~~ 169 (170) T 1yzq_A 142 NVMFIET---SAKAGYNVKQLFRR---VAAALPG 169 (170) T ss_dssp TCEEEEC---CTTTCTTHHHHHHH---HHHHSCC T ss_pred CCEEEEE---ECCCCCCHHHHHHH---HHHHHCC T ss_conf 9818998---62689788899999---9996037 No 61 >1mh1 RAC1; GTP-binding, GTPase, small G-protein, RHO family, RAS super family; HET: GNP; 1.38A {Homo sapiens} SCOP: c.37.1.8 Probab=97.20 E-value=0.027 Score=36.00 Aligned_columns=183 Identities=7% Q ss_pred CCCCEEEEECCCCHHHHHHHHHHCCCC-CCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCC Q ss_conf 664438997598331799999851477-8655665575025633562121332688998607854358878877187787 Q Fun_Sc_NP_0140 23 TATITAIIYSPSSKTLHQFINICFPEG-SNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHSS 101 (312) Q Consensus 23 ~~~k~~lilg~~~~~~~~fi~~l~~~~-~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s~ 101 (312) |.+..++++|.++.||++|++++..+. .+.+..+.+-.| ...+.-+ .....+.+|-..|.-........++ +. T Consensus 3 pk~iKv~iiG~~~vGKTSli~~~~~~~~~~~~~~t~~~~~-~~~i~~~-~~~~~l~i~D~~g~~~~~~~~~~~~----~~ 76 (186) T 1mh1 3 PQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNY-SANVMVD-GKPVNLGLWDTAGQEDYDRLRPLSY----PQ 76 (186) T ss_dssp CEEEEEEEECSTTSSHHHHHHHHHHSSCCSSCCCCSCCEE-EEEEEET-TEEEEEEEECCCCSGGGTTTGGGGC----TT T ss_pred CCEEEEEEECCCCCCHHHHHHHHHCCCCCCCCCCEEEEEE-EEEEECC-CCEEEEECCCCCCCHHHHHHHHHHH----HH T ss_conf 8258899870799878999999861753765355266545-5565126-8357641143553011222223443----13 Q ss_pred CCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCE Q ss_conf 82799985166634468999999999986406899873899847734566553245411578899999999999882941 Q Fun_Sc_NP_0140 102 KVRWLILLDWTLNDQKLWLNELSYAFNKIKQLNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSS 181 (312) Q Consensus 102 ~~l~ViLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGAS 181 (312) -..++++.|-+. ++++-.....|...++....+-+++||..|+|-.+.-+.....=.+..--.-.+-...++=..|+- T Consensus 77 ~~~~ilv~d~~~--~~Sf~~i~~~~~~~~~~~~~~~piiivgnK~Dl~~~~~~~~~~~~~~~~~~~~~~~~~~a~~~~~~ 154 (186) T 1mh1 77 TDVSLICFSLVS--PASFENVRAKWYPEVRHHCPNTPIILVGTKLDLRDDKDTIEKLKEKKLTPITYPQGLAMAKEIGAV 154 (186) T ss_dssp CSEEEEEEETTC--HHHHHHHHHTHHHHHHHHSTTSCEEEEEECHHHHTCHHHHHHHHHTTCCCCCHHHHHHHHHHTTCS T ss_pred HHCCEEEEECCC--HHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCC T ss_conf 101203552540--678899998877777650799689998537785221125667787530344568999999971893 Q ss_pred EEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCC Q ss_conf 5885256531355566778888753001247787752 Q Fun_Sc_NP_0140 182 LFYICEDHTEEKREEAQRLKYQELLKHFCEDRDMKDH 218 (312) Q Consensus 182 LiYts~ts~~~~kn~~~~l~y~~L~~h~l~~~~~~~~ 218 (312) .++. +|++...|...++.. ++..+..-|..+. T Consensus 155 ~~~e--~Sak~~~~i~e~f~~---l~~~~l~~~~~kk 186 (186) T 1mh1 155 KYLE--CSALTQRGLKTVFDE---AIRAVLCPPPVKK 186 (186) T ss_dssp EEEE--CCTTTCTTHHHHHHH---HHHHHSCCCC--- T ss_pred EEEE--EECCCCCCHHHHHHH---HHHHHHCCCCCCC T ss_conf 1799--750588788899999---9999836788889 No 62 >d1g16a_ c.37.1.8 (A:) Rab-related protein Sec4 {Baker's yeast (Saccharomyces cerevisiae)} Probab=97.19 E-value=0.031 Score=35.68 Aligned_columns=160 Identities=9% Q ss_pred EEEEECCCCHHHHHHHHHHCC-CCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCCCCEE Q ss_conf 389975983317999998514-7786556655750256335621213326889986078543588788771877878279 Q Fun_Sc_NP_0140 27 TAIIYSPSSKTLHQFINICFP-EGSNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHSSKVRW 105 (312) Q Consensus 27 ~~lilg~~~~~~~~fi~~l~~-~~~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s~~~l~ 105 (312) .++++|..+.||++|++++.. .-.+.+.++.+.+|....+..+ ....++..|-..+.-......-..+ ..-..+ T Consensus 4 Ki~ivG~~~vGKTsLi~~l~~~~~~~~~~~~~~~~~~~~~~~~~-~~~~~~~i~d~~g~~~~~~~~~~~~----~~~d~~ 78 (166) T d1g16a_ 4 KILLIGDSGVGKSCLLVRFVEDKFNPSFITTIGIDFKIKTVDIN-GKKVKLQIWDTAGQERFRTITTAYY----RGAMGI 78 (166) T ss_dssp EEEEEESTTSSHHHHHHHHHHCCCCC-------CCEEEEEEESS-SCEEEEEEECCTTGGGTSCCCHHHH----TTEEEE T ss_pred EEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEEC-CCCEEEEEEECCCCCCCCCHHHHHC----CCCCEE T ss_conf 89998079987999999986480077624454114688899875-8413688720578320000124332----699689 Q ss_pred EEEECCCCCCHHHHHHHHHHHHHHHHCCC-CCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEE Q ss_conf 99851666344689999999999864068-99873899847734566553245411578899999999999882941588 Q Fun_Sc_NP_0140 106 LILLDWTLNDQKLWLNELSYAFNKIKQLN-DDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSLFY 184 (312) Q Consensus 106 ViLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~-~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGASLiY 184 (312) ++..|-+ |+..+-.. +.|...++... .+-+++|+..|+| |++.. ...++ ++.++-.+|...+- T Consensus 79 i~v~d~~--~~~s~~~~-~~~~~~i~~~~~~~~piivv~nK~D----l~~~~-v~~~e--------~~~~~~~~~~~~~e 142 (166) T d1g16a_ 79 ILVYDIT--DERTFTNI-KQWFKTVNEHANDEAQLLLVGNKSD----METRV-VTADQ--------GEALAKELGIPFIE 142 (166) T ss_dssp EEEEETT--CHHHHHTH-HHHHHHHHHHSCTTCEEEEEEECTT----CTTCC-SCHHH--------HHHHHHHHTCCEEE T ss_pred EEEEECC--CCCHHHHH-HHHHHHHHHCCCCCCCEEEEEECHH----HHHCC-CCHHH--------HHHHHHHCCCCEEE T ss_conf 9998515--65338899-9999998612689851666763102----22006-75889--------99999965993999 Q ss_pred ECCCCCHHHHHHHHHHHHHHHHHHCCCCC Q ss_conf 52565313555667788887530012477 Q Fun_Sc_NP_0140 185 ICEDHTEEKREEAQRLKYQELLKHFCEDR 213 (312) Q Consensus 185 ts~ts~~~~kn~~~~l~y~~L~~h~l~~~ 213 (312) + |++...+-..++.. +++.++.+ T Consensus 143 ~---Sa~~g~gv~~lf~~---l~~~i~~~ 165 (166) T d1g16a_ 143 S---SAKNDDNVNEIFFT---LAKLIQEK 165 (166) T ss_dssp C---BTTTTBSHHHHHHH---HHHHHHHT T ss_pred E---ECCCCCCHHHHHHH---HHHHHHHH T ss_conf 9---61589888899999---99999970 No 63 >cd04109 Rab28 Rab28 subfamily. First identified in maize, Rab28 has been shown to be a late embryogenesis-abundant (Lea) protein that is regulated by the plant hormone abcisic acid (ABA). In Arabidopsis, Rab28 is expressed during embryo development and is generally restricted to provascular tissues in mature embryos. Unlike maize Rab28, it is not ABA-inducible. Characterization of the human Rab28 homolog revealed two isoforms, which differ by a 95-base pair insertion, producing an alternative sequence for the 30 amino acids at the C-terminus. The two human isoforms are presumbly the result of alternative splicing. Since they differ at the C-terminus but not in the GTP-binding region, they are predicted to be targeted to different cellular locations. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs Probab=97.18 E-value=0.2 Score=30.85 Aligned_columns=194 Identities=12% Q ss_pred EEEECCCCHHHHHHHHHHCC-CCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCCCCEEE Q ss_conf 89975983317999998514-77865566557502563356212133268899860785435887887718778782799 Q Fun_Sc_NP_0140 28 AIIYSPSSKTLHQFINICFP-EGSNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHSSKVRWL 106 (312) Q Consensus 28 ~lilg~~~~~~~~fi~~l~~-~~~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s~~~l~V 106 (312) ++++|+.+-|||.++.+... .-.+.+....|++|+...+.-+...+.++.+|-..|-.-...=.-.++-.++ .++ T Consensus 3 VvliGd~~VGKTSLi~rf~~~~F~~~y~~Tig~d~~~k~i~i~~~~~v~l~iwDtaGqe~~~~~~~~y~~~a~----~~i 78 (215) T cd04109 3 IVVLGDGAVGKTSLCRRFAKEGFGKSYKQTIGLDFFSKRVTLPGNLNVTLQVWDIGGQSIGGKMLDKYIYGAH----AVF 78 (215) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEEECCCCEEEEEEEECCCCCHHHHHHHHHHCCCC----EEE T ss_conf 8998269853899998877072177646514567878999975860589999864773023688998705998----489 Q ss_pred EEECCCCCCHHHHHHHHHHHHHHHHCCCCCCC-EEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEE Q ss_conf 98516663446899999999998640689987-38998477345665532454115788999999999998829415885 Q Fun_Sc_NP_0140 107 ILLDWTLNDQKLWLNELSYAFNKIKQLNDDNE-FSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSLFYI 185 (312) Q Consensus 107 iLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~Dt~-i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGASLiYt 185 (312) +.-|=+..+.-.-+......++....-....+ |++|--|+|- +..+.+=.+++ +.+|-++|+..|.| T Consensus 79 lVYdIt~~~SF~~i~~W~~~i~~~~~~~~~~~~iiLVGNK~DL----~~~R~Vs~ee~--------~~~A~~~~~~f~Ev 146 (215) T cd04109 79 LVYDVTNSQSFENLEDWYSMVRKVLKSSETQPLVVLVGNKTDL----EHNRTVKDDKH--------ARFAQANGMESCLV 146 (215) T ss_pred EEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCH----HHCCCCCHHHH--------HHHHHHCCCCEEEE T ss_conf 9975389768999999999999873105898189996054240----12066798999--------99999649959999 Q ss_pred CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCEEECCCCCHHHHHHHHCC Q ss_conf 25653135556677888875300124778775224011563020668881462420047 Q Fun_Sc_NP_0140 186 CEDHTEEKREEAQRLKYQELLKHFCEDRDMKDHIEMVTRSEILIPKGCDSIGLIKTVDE 244 (312) Q Consensus 186 s~ts~~~~kn~~~~l~y~~L~~h~l~~~~~~~~a~vverd~vfIP~GwDS~~KI~ii~E 244 (312) |+++..|-..++.. ++-.+.|-..++. ++-..+.+.-...-..-+.+++.++ T Consensus 147 ---SAktg~nV~elF~~---la~~i~~~~~~~~-~~~~~~~~~~~~~~~~~~~~~~~~~ 198 (215) T cd04109 147 ---SAKTGDRVNLLFQQ---LAAELLGVDLSKA-ELEQSQRVVKAVVVNTEERVSIPHQ 198 (215) T ss_pred ---ECCCCCCHHHHHHH---HHHHHHCCCCCHH-HCCCCCCCCCCCCCCCCCCEECCCC T ss_conf ---62679888899999---9999808631101-0454432000112344431004565 No 64 >cd01865 Rab3 Rab3 subfamily. The Rab3 subfamily contains Rab3A, Rab3B, Rab3C, and Rab3D. All four isoforms were found in mouse brain and endocrine tissues, with varying levels of expression. Rab3A, Rab3B, and Rab3C localized to synaptic and secretory vesicles; Rab3D was expressed at high levels only in adipose tissue, exocrine glands, and the endocrine pituitary, where it is localized to cytoplasmic secretory granules. Rab3 appears to control Ca2+-regulated exocytosis. The appropriate GDP/GTP exchange cycle of Rab3A is required for Ca2+-regulated exocytosis to occur, and interaction of the GTP-bound form of Rab3A with effector molecule(s) is widely believed to be essential for this process. Functionally, most studies point toward a role for Rab3 in the secretion of hormones and neurotransmitters. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promot Probab=97.18 E-value=0.092 Score=32.86 Aligned_columns=158 Identities=12% Q ss_pred EEEECCCCHHHHHHHHHHCC-CCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCCCCEEE Q ss_conf 89975983317999998514-77865566557502563356212133268899860785435887887718778782799 Q Fun_Sc_NP_0140 28 AIIYSPSSKTLHQFINICFP-EGSNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHSSKVRWL 106 (312) Q Consensus 28 ~lilg~~~~~~~~fi~~l~~-~~~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s~~~l~V 106 (312) ++++|+.+-|||+++.+... +=.+.+.+..|.+|....+.-+ .....+..|=..| .+.+..+.+..+ +.-.-++ T Consensus 4 iilvGd~~VGKTsli~rf~~~~f~~~y~~Ti~~~~~~k~i~~~-~~~v~l~iwDt~G-~e~~~~~~~~~~---~~~~~~i 78 (165) T cd01865 4 LLIIGNSSVGKTSFLFRYADDSFTSAFVSTVGIDFKVKTVFRN-DKRVKLQIWDTAG-QERYRTITTAYY---RGAMGFI 78 (165) T ss_pred EEEEECCCCCHHHHHHHHHCCEECCCCCCCEEEEEEEEEEEEC-CEEEEEEEEECCC-CCHHHHHHHHHC---CCCCEEE T ss_conf 9998079953899888764481066634303656789999877-9389999974588-701345656433---6998899 Q ss_pred EEECCCCCCHHHHHHHHHHHHHHHHCCC-CCCCEEEEEECCCHHHH--HHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEE Q ss_conf 9851666344689999999999864068-99873899847734566--55324541157889999999999988294158 Q Fun_Sc_NP_0140 107 ILLDWTLNDQKLWLNELSYAFNKIKQLN-DDNEFSVWCLNSGEILN--LQRHTTVWQSVHIDFILQTLRSFCYFNDSSLF 183 (312) Q Consensus 107 iLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~-~Dt~i~VVc~~sD~i~~--LEKe~~~w~de~fDfIqQ~LRtvcL~yGASLi 183 (312) +.-|-+. +..+ ..+.+|.+.+++.. .+.++++|-.|+|-... ...+.+ +.+|=++|...| T Consensus 79 ivfd~t~--~~Sf-~~i~~w~~~i~~~~~~~~~iilVGNK~Dl~~~r~v~~~~~--------------~~~a~~~~~~y~ 141 (165) T cd01865 79 LMYDITN--EESF-NAVQDWSTQIKTYSWDNAQVILVGNKCDMEDERVVSSERG--------------RQLADQLGFEFF 141 (165) T ss_pred EEEECCC--HHHH-HHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHH--------------HHHHHHCCCCEE T ss_conf 9986698--6689-9999999999860699608999721777246553138899--------------999996599499 Q ss_pred EECCCCCHHHHHHHHHHHHHHHHHHCCCCC Q ss_conf 852565313555667788887530012477 Q Fun_Sc_NP_0140 184 YICEDHTEEKREEAQRLKYQELLKHFCEDR 213 (312) Q Consensus 184 Yts~ts~~~~kn~~~~l~y~~L~~h~l~~~ 213 (312) .| |+++..|-...+.. ++..+..+ T Consensus 142 Et---SAk~~~nV~e~F~~---l~~~i~~k 165 (165) T cd01865 142 EA---SAKENINVKQVFER---LVDIICDK 165 (165) T ss_pred EE---ECCCCCCHHHHHHH---HHHHHHCC T ss_conf 99---71589887899999---99998429 No 65 >e1xtqa1 c.37.1.8 (A:3-169) GTP-binding protein RheB {Human (Homo sapiens) [TaxID:9606]} SCOP: u1xtsa_ u1xtra_ Probab=97.18 E-value=0.081 Score=33.17 Aligned_columns=164 Identities=7% Q ss_pred CCCCCEEEEECCCCHHHHHHHHHHCCCC-CCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCC Q ss_conf 3664438997598331799999851477-865566557502563356212133268899860785435887887718778 Q Fun_Sc_NP_0140 22 ETATITAIIYSPSSKTLHQFINICFPEG-SNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHS 100 (312) Q Consensus 22 ~~~~k~~lilg~~~~~~~~fi~~l~~~~-~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s 100 (312) ++.+.-++++|+.+.|||+|++++.... .+.+..+.+..|.... .-++..+.+.+.+.+..+..+.+....-... T Consensus 1 ~~k~~Ki~ivG~~~vGKTsLi~~~~~~~~~~~~~~t~~~~~~~~~----~~~~~~~~l~~~d~~g~~~~~~~~~~~~~~~ 76 (167) T e1xtqa1 1 QSKSRKIAILGYRSVGKSSLTIQFVEGQFVDSYDPTIENTFTKLI----TVNGQEYHLQLVDTAGQDEYSIFPQTYSIDI 76 (167) T ss_pred CCCCEEEEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEE----EECCEEEEEEEEEECCCCCCCCCCCCCCCCC T ss_conf 987417899816998799999998638116773440553107999----9824899999985036233434551114540 Q ss_pred CCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCC--CCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHC Q ss_conf 782799985166634468999999999986406--899873899847734566553245411578899999999999882 Q Fun_Sc_NP_0140 101 SKVRWLILLDWTLNDQKLWLNELSYAFNKIKQL--NDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFN 178 (312) Q Consensus 101 ~~~l~ViLLDWs~~Dp~~Wlr~Lr~~~~~L~~l--~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~y 178 (312) ..++++.|-+. +..+ ..++.|+..+.+. ..+.++++|+.|+| |+.+.....++.-.|..+ + T Consensus 77 --d~~ilv~d~~~--~~sf-~~~~~~~~~i~~~~~~~~~piiivgnK~D----l~~~~~v~~~~~~~~~~~--------~ 139 (167) T e1xtqa1 77 --NGYILVYSVTS--IKSF-EVIKVIHGKLLDMVGKVQIPIMLVGNKKD----LHMERVISYEEGKALAES--------W 139 (167) T ss_pred --EEEEEEEEECC--CCCH-HHHHHHHHHHHHHHCCCCCCEEEEEECCC----CCCCCCCCHHHHHHHHHH--------C T ss_conf --27999864123--2102-35677778998641257861899861346----422246898999999995--------5 Q ss_pred CCEEEEECCCCCHHHHHHHHHHHHHHHHHHC Q ss_conf 9415885256531355566778888753001 Q Fun_Sc_NP_0140 179 DSSLFYICEDHTEEKREEAQRLKYQELLKHF 209 (312) Q Consensus 179 GASLiYts~ts~~~~kn~~~~l~y~~L~~h~ 209 (312) |+..+.| |++...|-...+..--+-+++ T Consensus 140 ~~~~~e~---Sak~~~~v~e~f~~li~~~~k 167 (167) T e1xtqa1 140 NAAFLES---SAKENQTAVDVFRRIILEAEK 167 (167) T ss_pred CCEEEEE---ECCCCCCHHHHHHHHHHHHHC T ss_conf 9829999---715897778999999999819 No 66 >1xtq_A GTP-binding protein RHEB; beta saddle, P-loop; HET: GDP; 2.00A {Homo sapiens} SCOP: c.37.1.8 Probab=97.17 E-value=0.26 Score=30.19 Aligned_columns=164 Identities=10% Q ss_pred CCCCCEEEEECCCCHHHHHHHHHHCCCC-CCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCC Q ss_conf 3664438997598331799999851477-865566557502563356212133268899860785435887887718778 Q Fun_Sc_NP_0140 22 ETATITAIIYSPSSKTLHQFINICFPEG-SNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHS 100 (312) Q Consensus 22 ~~~~k~~lilg~~~~~~~~fi~~l~~~~-~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s 100 (312) .....-++++|..+.||++|++++..+. .+.+.++.+..|......++.. .++.+|-..|..... ....... T Consensus 3 ~~~~~Ki~iiG~~~vGKSsLi~~~~~~~~~~~~~~t~~~~~~~~~~~~~~~--~~l~i~D~~g~~~~~-----~~~~~~~ 75 (177) T 1xtq_A 3 QSKSRKIAILGYRSVGKSSLTIQFVEGQFVDSYDPTIENTFTKLITVNGQE--YHLQLVDTAGQDEYS-----IFPQTYS 75 (177) T ss_dssp CCEEEEEEEEESTTSSHHHHHHHHHHSCCCSCCCSSCCEEEEEEEEETTEE--EEEEEEECCCCCTTC-----CCCGGGT T ss_pred CCCCEEEEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEECCCCEE--EEEEEEECCCCCCCC-----CCCCCCC T ss_conf 887405899807998789999998627236664312320011210135445--664210011000112-----2233210 Q ss_pred -CCCEEEEEECCCCCCHHHHHHHHHHHHHHHHC--CCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH Q ss_conf -78279998516663446899999999998640--689987389984773456655324541157889999999999988 Q Fun_Sc_NP_0140 101 -SKVRWLILLDWTLNDQKLWLNELSYAFNKIKQ--LNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYF 177 (312) Q Consensus 101 -~~~l~ViLLDWs~~Dp~~Wlr~Lr~~~~~L~~--l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~ 177 (312) .-.-++++.|-+. +..+-. ++.|+..+.+ ...+.++++|++|+| |+.+. ....+ -.+.+|-. T Consensus 76 ~~~d~~i~v~d~~~--~~s~~~-~~~~~~~i~~~~~~~~~piiivgnK~D----l~~~~-~v~~~-------~~~~~~~~ 140 (177) T 1xtq_A 76 IDINGYILVYSVTS--IKSFEV-IKVIHGKLLDMVGKVQIPIMLVGNKKD----LHMER-VISYE-------EGKALAES 140 (177) T ss_dssp SSCCEEEEEEETTC--HHHHHH-HHHHHHHHHHHHCSSCCCEEEEEECTT----CGGGC-CSCHH-------HHHHHHHH T ss_pred HHHHHHHHHHCCCC--CCCCCH-HCCHHHHHHHHCCCCCCCEEEEEECCC----CHHHC-CCCHH-------HHHHHHHH T ss_conf 00333211000111--232000-010012211100357862699961257----30001-57888-------99999996 Q ss_pred CCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCC Q ss_conf 294158852565313555667788887530012 Q Fun_Sc_NP_0140 178 NDSSLFYICEDHTEEKREEAQRLKYQELLKHFC 210 (312) Q Consensus 178 yGASLiYts~ts~~~~kn~~~~l~y~~L~~h~l 210 (312) +|...|.| |++...+...++......++++ T Consensus 141 ~~~~~~e~---Sa~~g~gi~elf~~ii~~i~k~ 170 (177) T 1xtq_A 141 WNAAFLES---SAKENQTAVDVFRRIILEAEKL 170 (177) T ss_dssp HTCEEEEC---CTTCHHHHHHHHHHHHHHHHHH T ss_pred CCCEEEEE---ECCCCCCHHHHHHHHHHHHHHH T ss_conf 49828998---6168978889999999999987 No 67 >cd01861 Rab6 Rab6 subfamily. Rab6 is involved in microtubule-dependent transport pathways through the Golgi and from endosomes to the Golgi. Rab6A of mammals is implicated in retrograde transport through the Golgi stack, and is also required for a slow, COPI-independent, retrograde transport pathway from the Golgi to the endoplasmic reticulum (ER). This pathway may allow Golgi residents to be recycled through the ER for scrutiny by ER quality-control systems. Yeast Ypt6p, the homolog of the mammalian Rab6 GTPase, is not essential for cell viability. Ypt6p acts in endosome-to-Golgi, in intra-Golgi retrograde transport, and possibly also in Golgi-to-ER trafficking. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Probab=97.17 E-value=0.13 Score=31.99 Aligned_columns=157 Identities=9% Q ss_pred EEEECCCCHHHHHHHHHHCC-CCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCCCCEEE Q ss_conf 89975983317999998514-77865566557502563356212133268899860785435887887718778782799 Q Fun_Sc_NP_0140 28 AIIYSPSSKTLHQFINICFP-EGSNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHSSKVRWL 106 (312) Q Consensus 28 ~lilg~~~~~~~~fi~~l~~-~~~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s~~~l~V 106 (312) ++++|+.+.|||+|+.+... .-.+.+.+..|.+|....+.-+ ..+.++.+|=..| ...+..+.+.++ +.-..++ T Consensus 3 I~~iG~~~vGKTsli~r~~~~~f~~~~~~Tig~~~~~k~i~~~-~~~v~l~i~Dt~G-~e~~~~l~~~~~---~~~~~~i 77 (161) T cd01861 3 LVFLGDQSVGKTSIITRFMYDTFDNQYQATIGIDFLSKTMYLE-DKTVRLQLWDTAG-QERFRSLIPSYI---RDSSVAV 77 (161) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEEEC-CEEEEEEEECCCC-CHHHHHHHHHHC---CCCCCEE T ss_conf 8998179855899999886381266557434336888899887-9399999851788-425778889860---3888179 Q ss_pred EEECCCCCCHHHHHHHHHHHHHHHH-CCCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEE Q ss_conf 9851666344689999999999864-068998738998477345665532454115788999999999998829415885 Q Fun_Sc_NP_0140 107 ILLDWTLNDQKLWLNELSYAFNKIK-QLNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSLFYI 185 (312) Q Consensus 107 iLLDWs~~Dp~~Wlr~Lr~~~~~L~-~l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGASLiYt 185 (312) +.-|-+. +-.+-+ +..|+..++ ..+.+.++++|..|+|-...-+-.. +-.+.++-++|+..|-+ T Consensus 78 lvyd~t~--~~Sf~~-~~~w~~~i~~~~~~~~~iilVgNK~Dl~~~~~v~~------------~~~~~~a~~~~~~~~E~ 142 (161) T cd01861 78 VVYDITN--RQSFDN-TDKWIDDVRDERGNDVIIVLVGNKTDLSDKRQVST------------EEGEKKAKELNAMFIET 142 (161) T ss_pred EEEECCC--HHHHHH-HHHHHHHHHHHCCCCCEEEEEECCCCHHHCCCCCH------------HHHHHHHHHCCCCEEEE T ss_conf 9985398--768999-99999888862399978999715533212136768------------89999999659939999 Q ss_pred CCCCCHHHHHHHHHHHHHHHHHHCC Q ss_conf 2565313555667788887530012 Q Fun_Sc_NP_0140 186 CEDHTEEKREEAQRLKYQELLKHFC 210 (312) Q Consensus 186 s~ts~~~~kn~~~~l~y~~L~~h~l 210 (312) |++...|-...+.. ++..+ T Consensus 143 ---Sak~~~nV~e~F~~---ia~~l 161 (161) T cd01861 143 ---SAKAGHNVKELFRK---IASAL 161 (161) T ss_pred ---ECCCCCCHHHHHHH---HHHHC T ss_conf ---71489787899999---99839 No 68 >cd04132 Rho4_like Rho4-like subfamily. Rho4 is a GTPase that controls septum degradation by regulating secretion of Eng1 or Agn1 during cytokinesis. Rho4 also plays a role in cell morphogenesis. Rho4 regulates septation and cell morphology by controlling the actin cytoskeleton and cytoplasmic microtubules. The localization of Rho4 is modulated by Rdi1, which may function as a GDI, and by Rga9, which is believed to function as a GAP. In S. pombe, both Rho4 deletion and Rho4 overexpression result in a defective cell wall, suggesting a role for Rho4 in maintaining cell wall integrity. Most Rho proteins contain a lipid modification site at the C-terminus, with a typical sequence motif CaaX, where a = an aliphatic amino acid and X = any amino acid. Lipid binding is essential for membrane attachment, a key feature of most Rho proteins. Probab=97.17 E-value=0.16 Score=31.46 Aligned_columns=173 Identities=9% Q ss_pred CEEEEECCCCHHHHHHHHHHCC-CCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCCCCE Q ss_conf 4389975983317999998514-778655665575025633562121332688998607854358878877187787827 Q Fun_Sc_NP_0140 26 ITAIIYSPSSKTLHQFINICFP-EGSNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHSSKVR 104 (312) Q Consensus 26 k~~lilg~~~~~~~~fi~~l~~-~~~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s~~~l 104 (312) |-++++|+++-|||+++.+... .-.+.+.+..+..|.......+ .....+.+|=-.|. ..|-.+-+.....-. - T Consensus 1 ~KVvliGd~~VGKTsli~r~~~~~F~~~~~~Ti~~~~~~~~~~~~-~~~v~l~iwDtaGq-e~f~~l~~~~~~~a~---~ 75 (187) T cd04132 1 KKIVVVGDGGCGKTCLLIVYSQGKFPEEYVPTVFENYVTNIQGPN-GKIIELALWDTAGQ-EEYDRLRPLSYPDVD---V 75 (187) T ss_pred CEEEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEECC-CEEEEEEEECCCCC-HHHHHHHHHHHCCCC---E T ss_conf 968998179832899998876182267646515767899999738-81899986148775-245778887724897---5 Q ss_pred EEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEE Q ss_conf 99985166634468999999999986406899873899847734566553245411578899999999999882941588 Q Fun_Sc_NP_0140 105 WLILLDWTLNDQKLWLNELSYAFNKIKQLNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSLFY 184 (312) Q Consensus 105 ~ViLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGASLiY 184 (312) +++.-|-+. +..+-+....|+..+++...+.++++|..|+|-.+.-+...-+-.++. +.++-..|+..++ T Consensus 76 ~ilvyDit~--~~Sf~~~~~~W~~~i~~~~~~~piilVGNK~DL~~~~~~~r~V~~~e~--------~~~a~~~~~~~y~ 145 (187) T cd04132 76 LLICYAVDN--PTSLDNVEDKWFPEVNHFCPGTPIMLVGLKTDLRKDKNLDRKVTPAQA--------ESVAKKQGAFAYL 145 (187) T ss_pred EEEEEECCC--HHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHCCCCCCCHHHH--------HHHHHHCCCCEEE T ss_conf 899986599--789999998778999984589779998416751223111367898899--------9999973893268 Q ss_pred ECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCC Q ss_conf 5256531355566778888753001247787752 Q Fun_Sc_NP_0140 185 ICEDHTEEKREEAQRLKYQELLKHFCEDRDMKDH 218 (312) Q Consensus 185 ts~ts~~~~kn~~~~l~y~~L~~h~l~~~~~~~~ 218 (312) - +|++...|-..++.. ++-..+.++.+.. T Consensus 146 E--tSAk~g~nV~e~F~~---l~~~~l~~~~~~~ 174 (187) T cd04132 146 E--CSAKTMENVEEVFDT---AIEEALKKEGKAI 174 (187) T ss_pred E--EEECCCCCHHHHHHH---HHHHHHHCCCCCC T ss_conf 9--861278887899999---9999986047776 No 69 >1z06_A RAS-related protein RAB-33B; RAB GTPase, RAB33B GTPase, vesicular trafficking, protein transport; HET: GNP; 1.81A {Mus musculus} SCOP: c.37.1.8 Probab=97.16 E-value=0.23 Score=30.51 Aligned_columns=161 Identities=12% Q ss_pred EEEECCCCHHHHHHHHHHCC-CCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCCCCEEE Q ss_conf 89975983317999998514-77865566557502563356212133268899860785435887887718778782799 Q Fun_Sc_NP_0140 28 AIIYSPSSKTLHQFINICFP-EGSNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHSSKVRWL 106 (312) Q Consensus 28 ~lilg~~~~~~~~fi~~l~~-~~~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s~~~l~V 106 (312) ++++|..+.||++|++++.. ...+.+....+..|.+..+.-+ ..+..+..|-..+.........+..+. .-..++ T Consensus 23 v~ivG~~~vGKTsLi~~l~~~~~~~~~~~t~~~~~~~~~~~~~-~~~~~~~~~d~~g~~~~~~~~~~~~~~---~~~~~i 98 (189) T 1z06_A 23 IIVIGDSNVGKTCLTYRFCAGRFPDRTEATIGVDFRERAVDID-GERIKIQLWDTAGQERFRKSMVQHYYR---NVHAVV 98 (189) T ss_dssp EEEECCTTSSHHHHHHHHHHSSCCSSCCCCCSCCEEEEEEEET-TEEEEEEEEECCCSHHHHTTTHHHHHT---TCCEEE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEEEC-CCCCEEEEEECCCCHHHHHHHHHHHCC---CCCEEE T ss_conf 9998169987899999986381266624204445643567740-424368884056721343310032304---666689 Q ss_pred EEECCCCCCHHHHHHHHHHHHHHHHC--CCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEE Q ss_conf 98516663446899999999998640--6899873899847734566553245411578899999999999882941588 Q Fun_Sc_NP_0140 107 ILLDWTLNDQKLWLNELSYAFNKIKQ--LNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSLFY 184 (312) Q Consensus 107 iLLDWs~~Dp~~Wlr~Lr~~~~~L~~--l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGASLiY 184 (312) +..|-+ |+.+.-. +..|+..+++ ...+.++++|++|+|....-+=.. +-.+.+|-++|...+- T Consensus 99 ~v~d~~--~~~s~~~-i~~~~~~i~~~~~~~~~piilvgnK~Dl~~~~~i~~------------~~~~~~~~~~~~~~~e 163 (189) T 1z06_A 99 FVYDMT--NMASFHS-LPAWIEECKQHLLANDIPRILVGNKCDLRSAIQVPT------------DLAQKFADTHSMPLFE 163 (189) T ss_dssp EEEETT--CHHHHHT-HHHHHHHHHHHCCCSCCCEEEEEECTTCGGGCCSCH------------HHHHHHHHHTTCCEEE T ss_pred EEEECC--CCHHHHH-HHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCH------------HHHHHHHHHCCCCEEE T ss_conf 987325--5302578-999998753210268957999960678430024788------------9999999955991899 Q ss_pred ECCCCCHHHHHHHHHHHHHHHHHHCC Q ss_conf 52565313555667788887530012 Q Fun_Sc_NP_0140 185 ICEDHTEEKREEAQRLKYQELLKHFC 210 (312) Q Consensus 185 ts~ts~~~~kn~~~~l~y~~L~~h~l 210 (312) +|.-+.....|-...+.. +++.+ T Consensus 164 ~Sak~~~~~~~i~~~f~~---l~~~i 186 (189) T 1z06_A 164 TSAKNPNDNDHVEAIFMT---LAHKL 186 (189) T ss_dssp CCSSSGGGGSCHHHHHHH---HC--- T ss_pred EEECCCCCCCCHHHHHHH---HHHHH T ss_conf 840458888577899999---99998 No 70 >d1m7ba_ c.37.1.8 (A:) RhoE (RND3) {Mouse (Mus musculus)} SCOP: d1gwnc_ Probab=97.15 E-value=0.055 Score=34.16 Aligned_columns=173 Identities=7% Q ss_pred EEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCCCCEEEE Q ss_conf 89975983317999998514778655665575025633562121332688998607854358878877187787827999 Q Fun_Sc_NP_0140 28 AIIYSPSSKTLHQFINICFPEGSNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHSSKVRWLI 107 (312) Q Consensus 28 ~lilg~~~~~~~~fi~~l~~~~~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s~~~l~Vi 107 (312) ++++|+.+.||++|++++ -+.+.+.+..+-........-. .++..+.+-+.+.+..+....+.+.. -+.-..+++ T Consensus 5 I~iiG~~~vGKSsli~~~--~~~~f~~~~~~ti~~~~~~~~~-~~~~~~~~~i~Dt~g~~~~~~~~~~~--~~~~d~~il 79 (179) T d1m7ba_ 5 IVVVGDSQCGKTALLHVF--AKDCFPENYVPTVFENYTASFE-IDTQRIELSLWDTSGSPYYDNVRPLS--YPDSDAVLI 79 (179) T ss_dssp EEEEESTTSSHHHHHHHH--HHSCCCSSCCCCSEEEEEEEEE-CSSCEEEEEEEEECCSGGGTTTGGGG--CTTCSEEEE T ss_pred EEEEECCCCCHHHHHHHH--HCCCCCCCCCCEEEEEEEEEEE-ECCEEEEEEEEECCCCCCCCCCCHHH--HCCCCEEEE T ss_conf 999707998789999998--6284267624406888888655-15568999987135511003122033--317876999 Q ss_pred EECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECC Q ss_conf 85166634468999999999986406899873899847734566553245411578899999999999882941588525 Q Fun_Sc_NP_0140 108 LLDWTLNDQKLWLNELSYAFNKIKQLNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSLFYICE 187 (312) Q Consensus 108 LLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGASLiYts~ 187 (312) ..|.+. +...-.....|...++....+.++++|.+|+|-.+......-.-....--.-..-.+.++-.+|+-.++-|. T Consensus 80 v~d~~~--~~S~~~~~~~~~~~~~~~~~~~piilVgnK~DL~~~~~~~~~~~~~~~~~Vs~~e~~~la~~~~~~~y~E~S 157 (179) T d1m7ba_ 80 CFDISR--PETLDSVLKKWKGEIQEFCPNTKMLLVGCKSDLRTDVSTLVELSNHRQTPVSYDQGANMAKQIGAATYIECS 157 (179) T ss_dssp EEETTC--HHHHHHHHHTHHHHHHHHCTTCEEEEEEECGGGGGCHHHHHHHHTTTCCCCCHHHHHHHHHHHTCSEEEECB T ss_pred EEECCC--HHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEE T ss_conf 986376--146888853348999973487504656415554431135665542037747989999999971894389874 Q ss_pred CCCHHH-HHHHHHHHHHHHHH Q ss_conf 653135-55667788887530 Q Fun_Sc_NP_0140 188 DHTEEK-REEAQRLKYQELLK 207 (312) Q Consensus 188 ts~~~~-kn~~~~l~y~~L~~ 207 (312) ....++ -+..-.......+. T Consensus 158 A~~~~n~v~~vF~~~~~~~~~ 178 (179) T d1m7ba_ 158 ALQSENSVRDIFHVATLACVN 178 (179) T ss_dssp TTTBHHHHHHHHHHHHHHHHT T ss_pred ECCCCCHHHHHHHHHHHHHHC T ss_conf 036874189999999999842 No 71 >cd01860 Rab5_related Rab5-related subfamily. This subfamily includes Rab5 and Rab22 of mammals, Ypt51/Ypt52/Ypt53 of yeast, and RabF of plants. The members of this subfamily are involved in endocytosis and endocytic-sorting pathways. In mammals, Rab5 GTPases localize to early endosomes and regulate fusion of clathrin-coated vesicles to early endosomes and fusion between early endosomes. In yeast, Ypt51p family members similarly regulate membrane trafficking through prevacuolar compartments. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site at the C-terminus, with sequence mo Probab=97.12 E-value=0.17 Score=31.29 Aligned_columns=158 Identities=9% Q ss_pred EEEECCCCHHHHHHHHHHCC-CCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCCCCEEE Q ss_conf 89975983317999998514-77865566557502563356212133268899860785435887887718778782799 Q Fun_Sc_NP_0140 28 AIIYSPSSKTLHQFINICFP-EGSNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHSSKVRWL 106 (312) Q Consensus 28 ~lilg~~~~~~~~fi~~l~~-~~~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s~~~l~V 106 (312) ++++|..+.|||+|+.+... +=.+.+.+..|..|....+.-| .....++.|=..| ...+.++.+..... -.-++ T Consensus 4 i~iiG~~gvGKTsli~r~~~~~f~~~~~pTig~~~~~k~i~~~-~~~v~l~i~Dt~G-~e~~~~l~~~~~~~---a~~~i 78 (163) T cd01860 4 LVLLGDSSVGKSSLVLRFVKNEFSENQESTIGAAFLTQTVNLD-DTTVKFEIWDTAG-QERYRSLAPMYYRG---AAAAI 78 (163) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEEC-CEEEEEEEECCCC-CHHHHHHHHHHHCC---CCEEE T ss_conf 9998169965899999886283375535101322568899888-8799999704898-31245666765138---88499 Q ss_pred EEECCCCCCHHHHHHHHHHHHHHHHC-CCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEE Q ss_conf 98516663446899999999998640-68998738998477345665532454115788999999999998829415885 Q Fun_Sc_NP_0140 107 ILLDWTLNDQKLWLNELSYAFNKIKQ-LNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSLFYI 185 (312) Q Consensus 107 iLLDWs~~Dp~~Wlr~Lr~~~~~L~~-l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGASLiYt 185 (312) +.-|-+ ..-=...+..|+..+++ ...+.++++|..|+| |+.++..-.++ .+.+|-++|+..+.+ T Consensus 79 lvydit---~~~Sf~~i~~w~~~i~~~~~~~~~iilVgNK~D----l~~~r~v~~~e--------~~~~a~~~~~~~~e~ 143 (163) T cd01860 79 VVYDIT---SEESFEKAKSWVKELQRNASPNIIIALVGNKAD----LESKRQVSTEE--------AQEYADENGLLFFET 143 (163) T ss_pred EEEECC---CHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHH----HHHCCCCCHHH--------HHHHHHHCCCEEEEE T ss_conf 998659---978999999988765530699958999832210----54305887899--------999999659929999 Q ss_pred CCCCCHHHHHHHHHHHHHHHHHHCCC Q ss_conf 25653135556677888875300124 Q Fun_Sc_NP_0140 186 CEDHTEEKREEAQRLKYQELLKHFCE 211 (312) Q Consensus 186 s~ts~~~~kn~~~~l~y~~L~~h~l~ 211 (312) |+++..|-...+.. ++..+. T Consensus 144 ---SAk~~~nI~~~F~~---l~~~i~ 163 (163) T cd01860 144 ---SAKTGENVNELFTE---IAKKLP 163 (163) T ss_pred ---ECCCCCCHHHHHHH---HHHHCC T ss_conf ---71489888899999---998579 No 72 >2ew1_A RAS-related protein RAB-30; G-protein, GTP analogue, structural genomics, structural genomics consortium, SGC; HET: GNP; 2.00A {Homo sapiens} SCOP: c.37.1.8 Probab=97.12 E-value=0.27 Score=30.05 Aligned_columns=158 Identities=6% Q ss_pred EEEECCCCHHHHHHHHHHCCCC-CCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCCCCEEE Q ss_conf 8997598331799999851477-865566557502563356212133268899860785435887887718778782799 Q Fun_Sc_NP_0140 28 AIIYSPSSKTLHQFINICFPEG-SNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHSSKVRWL 106 (312) Q Consensus 28 ~lilg~~~~~~~~fi~~l~~~~-~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s~~~l~V 106 (312) ++++|..+.|||+|+.++..+. .+...++.+..+....+..+ .....+.+|-..|.-....-....+..++ .++ T Consensus 29 V~iiG~~~vGKTSLi~~l~~~~~~~~~~~t~~~~~~~~~i~~~-~~~~~~~i~D~~g~~~~~~~~~~~~~~~~----~~i 103 (201) T 2ew1_A 29 IVLIGNAGVGKTCLVRRFTQGLFPPGQGATIGVDFMIKTVEIN-GEKVKLQIWDTAGQERFRSITQSYYRSAN----ALI 103 (201) T ss_dssp EEEEESTTSSHHHHHHHHHHSSCCTTCCCCCSEEEEEEEEEET-TEEEEEEEEEECCSGGGHHHHGGGSTTCS----EEE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEEEE-EEEEEEEEEECCCCCHHHHHHHHHHHHCC----CEE T ss_conf 9998179987899999986483257635541047899999875-58999998743786302478898864105----448 Q ss_pred EEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEC Q ss_conf 98516663446899999999998640689987389984773456655324541157889999999999988294158852 Q Fun_Sc_NP_0140 107 ILLDWTLNDQKLWLNELSYAFNKIKQLNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSLFYIC 186 (312) Q Consensus 107 iLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGASLiYts 186 (312) +..|-+ |+..+-..-..+-...+......++++|.+|+|....-+-. .+-++.++-.+|...+-+ T Consensus 104 ~v~d~~--d~~s~~~~~~~~~~~~~~~~~~~piiivgnK~Dl~~~~~v~------------~~e~~~~a~~~~~~~~e~- 168 (201) T 2ew1_A 104 LTYDIT--CEESFRCLPEWLREIEQYASNKVITVLVGNKIDLAERREVS------------QQRAEEFSEAQDMYYLET- 168 (201) T ss_dssp EEEETT--CHHHHHTHHHHHHHHHHHSCTTCEEEEEEECGGGGGGCSSC------------HHHHHHHHHHHTCCEEEC- T ss_pred EEEEEC--CCCHHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHCCC------------HHHHHHHHHHCCCEEEEE- T ss_conf 999611--31011011110001000012410000011100112220100------------889999999559829999- Q ss_pred CCCCHHHHHHHHHHHHHHHHHHCC Q ss_conf 565313555667788887530012 Q Fun_Sc_NP_0140 187 EDHTEEKREEAQRLKYQELLKHFC 210 (312) Q Consensus 187 ~ts~~~~kn~~~~l~y~~L~~h~l 210 (312) |++...+-..++.. ++..+ T Consensus 169 --Sak~g~gI~~lf~~---l~~~l 187 (201) T 2ew1_A 169 --SAKESDNVEKLFLD---LACRL 187 (201) T ss_dssp --CTTTCTTHHHHHHH---HHHHH T ss_pred --ECCCCCCHHHHHHH---HHHHH T ss_conf --61589788899999---99999 No 73 >2a5j_A RAS-related protein RAB-2B; GTPase, signal transduction, structural genomics, structural genomics consortium, SGC; HET: GDP; 1.50A {Homo sapiens} SCOP: c.37.1.8 Probab=97.12 E-value=0.12 Score=32.12 Aligned_columns=175 Identities=6% Q ss_pred HHHCCCCCCCCCCCC---EEEEECCCCHHHHHHHHHHCCCC-CCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHH Q ss_conf 641011465536644---38997598331799999851477-86556655750256335621213326889986078543 Q Fun_Sc_NP_0140 12 SQNESTINSTETATI---TAIIYSPSSKTLHQFINICFPEG-SNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDD 87 (312) Q Consensus 12 se~~~~~~~k~~~~k---~~lilg~~~~~~~~fi~~l~~~~-~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~ 87 (312) ++-++.++|-.|... .++|+|+.+.|||+|+.++.... .....+..+.+.....+.-. ....++..|-..+.... T Consensus 5 ~~~~~~~~~~~p~~~~~~KIvivG~~~vGKTSLi~~l~~~~f~~~~~~t~~~~~~~~~~~~~-~~~~~~~i~d~~g~~~~ 83 (191) T 2a5j_A 5 HHHHHHSSGLVPRGSYLFKYIIIGDTGVGKSCLLLQFTDKRFQPVHDLTIGVEFGARMVNID-GKQIKLQIWDTAGQESF 83 (191) T ss_dssp -----CCCCCCCTTCEEEEEEEESSTTSSHHHHHHHHHHSCCCC-----CCSSEEEEEEEET-TEEEEEEEECCTTGGGT T ss_pred CCCCCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCEECCCCEEEEEEC-CEEEEEEEEECCCHHHH T ss_conf 23444445789873432789998179976899999986382267624511012304542212-50577776302111122 Q ss_pred HHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHH Q ss_conf 58878877187787827999851666344689999999999864068998738998477345665532454115788999 Q Fun_Sc_NP_0140 88 ALDLLKPFLQEHSSKVRWLILLDWTLNDQKLWLNELSYAFNKIKQLNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFI 167 (312) Q Consensus 88 ~~~LLkp~L~~~s~~~l~ViLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfI 167 (312) ........-..+ .++++.|-+ |+...-+.-+.+....+....+.+++||+.|+|....-+-.. T Consensus 84 ~~~~~~~~~~~d----~ii~vfd~~--d~~sf~~~~~~~~~~~~~~~~~~piilv~nK~D~~~~~~v~~----------- 146 (191) T 2a5j_A 84 RSITRSYYRGAA----GALLVYDIT--RRETFNHLTSWLEDARQHSSSNMVIMLIGNKSDLESRRDVKR----------- 146 (191) T ss_dssp SCCCHHHHTTCS----EEEEEEETT--CHHHHHTHHHHHHHHHHHSCTTCEEEEEEECTTCGGGCCSCH----------- T ss_pred HHHHHHHHHCCC----EEEEEEEEC--CCHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHCCCCH----------- T ss_conf 234365431277----579998405--620588887642100124799707998515320002105568----------- Q ss_pred HHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCC Q ss_conf 99999999882941588525653135556677888875300124 Q Fun_Sc_NP_0140 168 LQTLRSFCYFNDSSLFYICEDHTEEKREEAQRLKYQELLKHFCE 211 (312) Q Consensus 168 qQ~LRtvcL~yGASLiYts~ts~~~~kn~~~~l~y~~L~~h~l~ 211 (312) +-++.++-++|...+.+ |++...|...++.. ++..++ T Consensus 147 -~e~~~~~~~~~~~~~e~---Sak~g~gI~elf~~---i~~~i~ 183 (191) T 2a5j_A 147 -EEGEAFAREHGLIFMET---SAKTACNVEEAFIN---TAKEIY 183 (191) T ss_dssp -HHHHHHHHHHTCEEEEE---CTTTCTTHHHHHHH---HHHHHH T ss_pred -HHHHHHHHHCCCEEEEE---ECCCCCCHHHHHHH---HHHHHH T ss_conf -89999999659909999---61689788899999---999999 No 74 >d1i2ma_ c.37.1.8 (A:) Ran {Human (Homo sapiens)} SCOP: d1k5da_ d1a2ke_ d1rrpa_ d1a2kd_ d1a2kc_ d1qg4a_ d1qg2a_ d1qbkc_ d1byua_ d3ranb_ d3ranc_ d3rana_ d1rrpc_ d1wa5a_ d1ibra_ Probab=97.12 E-value=0.0096 Score=38.66 Aligned_columns=164 Identities=5% Q ss_pred EEEECCCCHHHHHHHHHHCCCC-CCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCCCCEEE Q ss_conf 8997598331799999851477-865566557502563356212133268899860785435887887718778782799 Q Fun_Sc_NP_0140 28 AIIYSPSSKTLHQFINICFPEG-SNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHSSKVRWL 106 (312) Q Consensus 28 ~lilg~~~~~~~~fi~~l~~~~-~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s~~~l~V 106 (312) ++++|+.+.||++|++++..+. .+.+.++.+.++....+..+ .....+..|-..+....-...-..+..++ . T Consensus 6 I~ivG~~~vGKSsLi~~~~~~~~~~~~~~ti~~~~~~~~i~~~-~~~~~l~i~D~~g~~~~~~~~~~~~~~~~------~ 78 (170) T d1i2ma_ 6 LVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLVFHTN-RGPIKFNVWDTAGQEKFGGLRDGYYIQAQ------C 78 (170) T ss_dssp EEEEECTTSSHHHHHHTTC-----CCEEEETTEEEEEEEECBT-TCCEEEEEEECTTHHHHSSCGGGGTTTCC------E T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEEEC-CCEEEEEEEECCCCHHHCCCCCHHCCCCC------E T ss_conf 9998179987999999986382057624448875578999876-95147888403330011002300016875------8 Q ss_pred EEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEC Q ss_conf 98516663446899999999998640689987389984773456655324541157889999999999988294158852 Q Fun_Sc_NP_0140 107 ILLDWTLNDQKLWLNELSYAFNKIKQLNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSLFYIC 186 (312) Q Consensus 107 iLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGASLiYts 186 (312) +++-++..|+..+-. ++.|+...+....+.++++|..|+|-...-..+.. ..++-.+|...+.+ T Consensus 79 ~ilv~d~~~~~s~~~-~~~~~~~~~~~~~~~piiiv~nK~Dl~~~~~~~e~--------------~~~a~~~~~~~~e~- 142 (170) T d1i2ma_ 79 AIIMFDVTSRVTYKN-VPNWHRDLVRVCENIPIVLCGNKVDIKDRKVKAKS--------------IVFHRKKNLQYYDI- 142 (170) T ss_dssp EEEEEETTSGGGGTT-HHHHHHHHHHHHCSCCEEEEEECCCCSCSCCTTTS--------------HHHHSSCSSEEEEE- T ss_pred EEEEEECCCCCCHHH-HHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHH--------------HHHHHHCCCEEEEE- T ss_conf 999962367640789-99988767641587628999713340010017899--------------99998469809999- Q ss_pred CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCC Q ss_conf 565313555667788887530012477877522 Q Fun_Sc_NP_0140 187 EDHTEEKREEAQRLKYQELLKHFCEDRDMKDHI 219 (312) Q Consensus 187 ~ts~~~~kn~~~~l~y~~L~~h~l~~~~~~~~a 219 (312) |++...|-..++.. ++..+.+-|....+ T Consensus 143 --Sak~g~~i~e~f~~---l~~~l~~~p~l~~~ 170 (170) T d1i2ma_ 143 --SAKSNYNFEKPFLW---LARKLIGDPNLEFV 170 (170) T ss_dssp --BTTTTBTTTHHHHH---HHHHHHTCTTCCBC T ss_pred --ECCCCCCHHHHHHH---HHHHHHCCCCEEEC T ss_conf --71589898899999---99998448864308 No 75 >2g3y_A GTP-binding protein GEM; small GTPase, GDP, inactive state, RGK family, structural genomics, structural genomics consortium, SGC; HET: GDP; 2.40A {Homo sapiens} SCOP: c.37.1.8 Probab=97.12 E-value=0.11 Score=32.37 Aligned_columns=192 Identities=12% Q ss_pred CHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHCC--CCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEEE Q ss_conf 13889988641011465536644389975983317999998514--7786556655750256335621213326889986 Q Fun_Sc_NP_0140 4 CNAWDKLLSQNESTINSTETATITAIIYSPSSKTLHQFINICFP--EGSNSILDTTLINYATIGWTNDLKENYSVDVYTL 81 (312) Q Consensus 4 ~NlWs~iLse~~~~~~~k~~~~k~~lilg~~~~~~~~fi~~l~~--~~~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L 81 (312) .||-.+..+.+++..+..-..--.++++|..+.||++|++++.. +..+......+.+++...+.-+ .....+-.+-+ T Consensus 16 ~~~~~~~~~~~~~~~~~~~~~~~KI~lvG~~~vGKSsLi~rl~~~~~~~~~~~~~~~~~~~~~~i~~d-~~~~~~~~~~i 94 (211) T 2g3y_A 16 ENLYFQSMSTDSVISSESGNTYYRVVLIGEQGVGKSTLANIFAGVHDSMDSDCEVLGEDTYERTLMVD-GESATIILLDM 94 (211) T ss_dssp -------------------CCEEEEEEECCTTSSHHHHHHHHHCCCCTTCCC---CCTTEEEEEEEET-TEEEEEEEECC T ss_pred CCCEECCCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEEEEC-CCEEEEEEEEC T ss_conf 44100001222113567888258999982898658898877752655325435751788899999634-86168998611 Q ss_pred ECCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCCCH Q ss_conf 07854358878877187787827999851666344689999999999864068998738998477345665532454115 Q Fun_Sc_NP_0140 82 IRNTDDALDLLKPFLQEHSSKVRWLILLDWTLNDQKLWLNELSYAFNKIKQLNDDNEFSVWCLNSGEILNLQRHTTVWQS 161 (312) Q Consensus 82 ~~~~~~~~~LLkp~L~~~s~~~l~ViLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~Dt~i~VVc~~sD~i~~LEKe~~~w~d 161 (312) -+..++..-+.+-.+..-. .++++.|-+..+.-..+......+..... ..+.+++||..|+|....-+-.. T Consensus 95 ~d~~g~e~~~~~~~~~~~d---~~ilvfD~~~~~S~~~i~~~~~~i~~~~~-~~~~piiivgnK~Dl~~~~~i~~----- 165 (211) T 2g3y_A 95 WENKGENEWLHDHCMQVGD---AYLIVYSITDRASFEKASELRIQLRRARQ-TEDIPIILVGNKSDLVRCREVSV----- 165 (211) T ss_dssp TTTTHHHHHHHHCCCCCCS---EEEEEEETTCHHHHHHHHHHHHHHHTSGG-GTTSCEEEEEECTTCGGGCCSCH----- T ss_pred CCCCCCCCCCCHHHHCCCE---EEEEEEEEECCCCCCCCCCCCEEEEECCC-CCCEEEEEEECCCCCCCCCCCCH----- T ss_conf 1011000001112220340---34434432104542322123100000134-45168999702578001046788----- Q ss_pred HHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCC Q ss_conf 788999999999998829415885256531355566778888753001247787752 Q Fun_Sc_NP_0140 162 VHIDFILQTLRSFCYFNDSSLFYICEDHTEEKREEAQRLKYQELLKHFCEDRDMKDH 218 (312) Q Consensus 162 e~fDfIqQ~LRtvcL~yGASLiYts~ts~~~~kn~~~~l~y~~L~~h~l~~~~~~~~ 218 (312) .-.+.++-.+|+..+-+ |++...+...++.. +++.+..+...+. T Consensus 166 -------~e~~~~~~~~~~~~~e~---SAk~g~gI~elf~~---i~~~i~~~~~~ke 209 (211) T 2g3y_A 166 -------SEGRACAVVFDCKFIET---SAAVQHNVKELFEG---IVRQVRLRRDSKE 209 (211) T ss_dssp -------HHHHHHHHHHTCEEEEC---BTTTTBSHHHHHHH---HHHHHHHHCC--- T ss_pred -------HHHHHHHHHCCCCEEEE---ECCCCCCHHHHHHH---HHHHHHHHHHCCC T ss_conf -------99999999649938999---70488688899999---9999986432013 No 76 >2hup_A RAS-related protein RAB-43; G-protein, GDP, structural genomics, structural genomics consortium, SGC; HET: GDP; 2.05A {Homo sapiens} Probab=97.12 E-value=0.37 Score=29.23 Aligned_columns=163 Identities=10% Q ss_pred EEEECCCCHHHHHHHHHHCCCC-CCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCCCCEEE Q ss_conf 8997598331799999851477-865566557502563356212133268899860785435887887718778782799 Q Fun_Sc_NP_0140 28 AIIYSPSSKTLHQFINICFPEG-SNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHSSKVRWL 106 (312) Q Consensus 28 ~lilg~~~~~~~~fi~~l~~~~-~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s~~~l~V 106 (312) ++++|+...||++|+.++.... .+.+.+..+..+....+.-+ ....++.+|-..+.-.........+.+++ -++ T Consensus 32 I~viG~~~vGKTSLi~~~~~~~~~~~~~~~~~~~~~~~~i~~~-~~~~~~~i~D~~g~~~~~~~~~~~~~~~~----~ii 106 (201) T 2hup_A 32 LVLVGDASVGKTCVVQRFKTGAFSERQGSTIGVDFTMKTLEIQ-GKRVKLQIWDTAGQERFRTITQSYYRSAN----GAI 106 (201) T ss_dssp EEEEECTTSSHHHHHHHHHHSCC----------CEEEEEEEET-TEEEEEEEECCTTCGGGHHHHHHHHTTCS----EEE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEEE-EEEEEEEECCCCCCHHHHHHHHHHCCCCE----EEE T ss_conf 9998269977899999986582355425434406889988643-36788875057773035677663235732----899 Q ss_pred EEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEC Q ss_conf 98516663446899999999998640689987389984773456655324541157889999999999988294158852 Q Fun_Sc_NP_0140 107 ILLDWTLNDQKLWLNELSYAFNKIKQLNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSLFYIC 186 (312) Q Consensus 107 iLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGASLiYts 186 (312) ++.|-+. +...-..-+.|....+....+-++++|++|+| |+... ....+.. +.++-.+|+--+|-+ T Consensus 107 ~v~d~~~--~~s~~~i~~~~~~i~~~~~~~~p~ilV~nK~D----l~~~~-~i~~~e~-------~~~a~~~~~~~~~e~ 172 (201) T 2hup_A 107 LAYDITK--RSSFLSVPHWIEDVRKYAGSNIVQLLIGNKSD----LSELR-EVSLAEA-------QSLAEHYDILCAIET 172 (201) T ss_dssp EEEETTB--HHHHHTHHHHHHHHHHHSCTTCEEEEEEECTT----CGGGC-CSCHHHH-------HHHHHHTTCSEEEEC T ss_pred EEEECCC--CCCCCCCHHHHHCCCCCCCCCEEEEEEECCCC----HHHHC-CCCHHHH-------HHHHHHCCCCEEEEE T ss_conf 9720564--21232100111000123446424566530245----12320-3347899-------999996399368986 Q ss_pred CCCCHHHHHHHHHHHHHHHHHHC Q ss_conf 56531355566778888753001 Q Fun_Sc_NP_0140 187 EDHTEEKREEAQRLKYQELLKHF 209 (312) Q Consensus 187 ~ts~~~~kn~~~~l~y~~L~~h~ 209 (312) .....+.-+++..-+...++.+. T Consensus 173 Sak~g~gI~elf~~i~~~il~r~ 195 (201) T 2hup_A 173 SAKDSSNVEEAFLRVATELIMRH 195 (201) T ss_dssp BTTTTBSHHHHHHHHHHHHHHHT T ss_pred EECCCCCHHHHHHHHHHHHHHHC T ss_conf 40588688899999999999815 No 77 >PF00071 Ras: Ras family; InterPro: IPR013753 Many members of the Ras superfamily of GTPases have been implicated in the regulation of hematopoietic cells, with roles in growth, survival, differentiation, cytokine production, chemotaxis, vesicle-trafficking, and phagocytosis. The Ras superfamily of proteins now includes over 150 small GTPases (distinguished from the large, heterotrimeric GTPases, the G-proteins). It comprises six subfamilies, the Ras, Rho, Ran, Rab, Arf, and Kir/Rem/Rad subfamilies . They exhibit remarkable overall amino acid identities, especially in the regions interacting with the guanine nucleotide exchange factors that catalyze their activation . ; PDB: 2fol_A 1ukv_Y 1yzn_A 2bcg_Y 1g17_B 1g16_C 3rab_A 1zbd_A 2ew1_A 1x3s_A .... Probab=97.11 E-value=0.24 Score=30.37 Aligned_columns=154 Identities=10% Q ss_pred EEEECCCCHHHHHHHHHHCCCCCC-CCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCCCCEEE Q ss_conf 899759833179999985147786-5566557502563356212133268899860785435887887718778782799 Q Fun_Sc_NP_0140 28 AIIYSPSSKTLHQFINICFPEGSN-SILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHSSKVRWL 106 (312) Q Consensus 28 ~lilg~~~~~~~~fi~~l~~~~~e-~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s~~~l~V 106 (312) ++++|+.+.|||+|+.+.....-. .+.+..|.++....+.-+ ....++.+|=-.|- +.|..+.+.++.. -.-++ T Consensus 2 iiliG~~~vGKTsl~~r~~~~~f~~~y~~TiG~d~~~~~i~~~-~~~v~l~iwDTaGq-e~f~~l~~~~~~~---a~~~i 76 (174) T PF00071_consen 2 IILIGDSGVGKTSLIKRFVEGEFIESYTPTIGVDFYSKTIQID-GKSVKLQIWDTAGQ-ERFRSLRSSYYRN---ADGVI 76 (174) T ss_dssp EEEEESTTSSHHHHHHHHHHSSSSSSCETSSSEEEEEEEEEET-TEEEEEEEEEETSS-GGGHHHHHHHHTT---ESEEE T ss_pred EEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCC-CCEEEEEEEEEECC-CCCCCCCHHHEEE---EEEEE T ss_conf 7888089853334200121134411122444401223200267-73478988731023-1001220011001---12466 Q ss_pred EEECCCCCCHHHHHHHHHHHHHHHHCCCC---CCCEEEEEECCCHHHHHHHCCCCCCHH-------HHHHHHHHHHHHHH Q ss_conf 98516663446899999999998640689---987389984773456655324541157-------88999999999998 Q Fun_Sc_NP_0140 107 ILLDWTLNDQKLWLNELSYAFNKIKQLND---DNEFSVWCLNSGEILNLQRHTTVWQSV-------HIDFILQTLRSFCY 176 (312) Q Consensus 107 iLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~---Dt~i~VVc~~sD~i~~LEKe~~~w~de-------~fDfIqQ~LRtvcL 176 (312) +.-|-+. +..+.+. ..|+..++.... +.++++|..|+|-.. ++ +--.-.+-.+.+|- T Consensus 77 lvydit~--~~Sf~~i-~~w~~~i~~~~~~~~~~~iiLVGnK~DL~~----------~~~~~~~~~~r~V~~~e~~~~a~ 143 (174) T PF00071_consen 77 LVYDITN--RESFENI-KKWIEEIKKIAPKDENIPIILVGNKSDLKE----------EESTELENKQRQVSTEEAQQLAK 143 (174) T ss_dssp EEEETTH--HHHHHHH-HHHHHHHHHHSTSSTTSEEEEEEETTCGGG----------CHHHHHCTSGSSSHHHHHHHHHH T ss_pred EEEEEEC--CCEEHHH-HHHHHHHCCCCCCCCHHHEEEEECCCCCCC----------CCHHHHCCCCCHHHHHHHHHHHH T ss_conf 7875300--1100001-222232002556320011001110354433----------10010002210245577889998 Q ss_pred HCC-CEEEEECCCCCHHHHHHHHHHHH Q ss_conf 829-41588525653135556677888 Q Fun_Sc_NP_0140 177 FND-SSLFYICEDHTEEKREEAQRLKY 202 (312) Q Consensus 177 ~yG-ASLiYts~ts~~~~kn~~~~l~y 202 (312) .+| ...|-| |++...|-...+.. T Consensus 144 ~~~~~~~~Et---SAk~~~ni~~~F~~ 167 (174) T PF00071_consen 144 KLGAIKFFET---SAKTGENIEELFQT 167 (174) T ss_dssp HTTSSEEEEE---BTTTTTTHHHHHHH T ss_pred HHCCCCEEEE---ECCCCCCHHHHHHH T ss_conf 7338741686---44678787899999 No 78 >1x1r_A RAS-related protein M-RAS; GTP-binding; HET: GDP; 1.30A {Mus musculus} SCOP: c.37.1.8 Probab=97.11 E-value=0.13 Score=32.03 Aligned_columns=174 Identities=9% Q ss_pred CCCCCCCCCCCCEEEEECCCCHHHHHHHHHHCC-CCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHH Q ss_conf 011465536644389975983317999998514-7786556655750256335621213326889986078543588788 Q Fun_Sc_NP_0140 15 ESTINSTETATITAIIYSPSSKTLHQFINICFP-EGSNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLK 93 (312) Q Consensus 15 ~~~~~~k~~~~k~~lilg~~~~~~~~fi~~l~~-~~~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLk 93 (312) ++-.+.+..++-.++++|..+.||++|++++.. .-.+.+....+..|.....-++ ....+.+|-..+.-........ T Consensus 3 ~~~~p~~~~~~~Ki~iiG~~~vGKTsll~~l~~~~~~~~~~~t~~~~~~~~~~~~~--~~~~~~i~d~~g~e~~~~~~~~ 80 (178) T 1x1r_A 3 TSAVPSENLPTYKLVVVGDGGVGKSALTIQFFQKIFVPDYDPTIEDSYLKHTEIDN--QWAILDVLDTAGQEEFSAMREQ 80 (178) T ss_dssp -------CCCEEEEEEECCTTSSHHHHHHHHHHSSCCTTCCTTCCEEEEEEEEETT--EEEEEEEEECCSCGGGCSSHHH T ss_pred CCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCEECCCCCCCCCCC--CEEEEEEEEECCCCCCCCCCHH T ss_conf 67788767866899988179977899999986282377545411001120012378--1478877751365323325400 Q ss_pred HHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHH Q ss_conf 77187787827999851666344689999999999864068998738998477345665532454115788999999999 Q Fun_Sc_NP_0140 94 PFLQEHSSKVRWLILLDWTLNDQKLWLNELSYAFNKIKQLNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRS 173 (312) Q Consensus 94 p~L~~~s~~~l~ViLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRt 173 (312) ..-+.+ .+++..|.+..+...+++.....+.... ...+.++++|+.|+| +..+.....++ ++. T Consensus 81 ~~~~~~----~~i~vfd~~~~~S~~~~~~~~~~~~~~~-~~~~~piiiVgnK~D----~~~~~~v~~~e--------~~~ 143 (178) T 1x1r_A 81 YMRTGD----GFLIVYSVTDKASFEHVDRFHQLILRVK-DRESFPMILVANKVD----LMHLRKVTRDQ--------GKE 143 (178) T ss_dssp HHHHCS----EEEEEEETTCHHHHHTHHHHHHHHHHHH-TSSCCCEEEEEECTT----CSTTCCSCHHH--------HHH T ss_pred HCCCCC----EEEEEEECCCCCCHHHHHHHHHHHHHHC-CCCCCEEEEEEECCC----CCCCCCCCHHH--------HHH T ss_conf 104785----4799974245421124456666665302-567640467752455----21003558899--------999 Q ss_pred HHHHCCCEEEEECCCCCHHHH-HHHHHHHHHHHHHHCCCCC Q ss_conf 998829415885256531355-5667788887530012477 Q Fun_Sc_NP_0140 174 FCYFNDSSLFYICEDHTEEKR-EEAQRLKYQELLKHFCEDR 213 (312) Q Consensus 174 vcL~yGASLiYts~ts~~~~k-n~~~~l~y~~L~~h~l~~~ 213 (312) +|-+||...+.+ |++... |-...+.. +++.++.+ T Consensus 144 ~~~~~~~~~~e~---Sak~~~~~i~e~f~~---i~~~i~k~ 178 (178) T 1x1r_A 144 MATKYNIPYIET---SAKDPPLNVDKTFHD---LVRVIRQQ 178 (178) T ss_dssp HHHHHTCCEEEE---BCSSSCBSHHHHHHH---HHHHHHHC T ss_pred HHHHCCCCEEEE---EECCCCCCHHHHHHH---HHHHHHHC T ss_conf 999659948999---615488787899999---99999829 No 79 >cd01864 Rab19 Rab19 subfamily. Rab19 proteins are associated with Golgi stacks. Similarity analysis indicated that Rab41 is closely related to Rab19. However, the function of these Rabs is not yet chracterized. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site at the C-terminus, with sequence motifs CC, CXC, or CCX. Lipid binding is essential for membrane attachment, a key feature of most Rab proteins. Due to the presence of truncated sequences in this CD, the lipid modification site is not available for annotation. Probab=97.11 E-value=0.19 Score=31.05 Aligned_columns=157 Identities=8% Q ss_pred EEEECCCCHHHHHHHHHHCC-CCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCCCCEEE Q ss_conf 89975983317999998514-77865566557502563356212133268899860785435887887718778782799 Q Fun_Sc_NP_0140 28 AIIYSPSSKTLHQFINICFP-EGSNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHSSKVRWL 106 (312) Q Consensus 28 ~lilg~~~~~~~~fi~~l~~-~~~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s~~~l~V 106 (312) ++++|+.+-|||+|+.+... .-.+.+.+..|.++....+.- ++.++.+.+.+.+.-+-...+.+..-..+.-..+| T Consensus 6 ivivGd~~vGKTsli~rf~~~~F~~~~~~tig~~~~~k~i~~---~~~~v~l~iwDt~G~e~~~~l~~~~~~~~~~~ilv 82 (165) T cd01864 6 IILIGDSNVGKTCVVQRFKSGTFSERQGNTIGVDFTMKTLEI---EGKRVKLQIWDTAGQERFRTITQSYYRSANGAIIA 82 (165) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEE---CCEEEEEEEEECCCCCHHHHHHHHHCCCCCEEEEE T ss_conf 999807994489999987628207766771125778999998---89589999975488701357768642699879999 Q ss_pred EEECCCCCCHHHHHHHHHHHHHHHHCC-CCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEE-EE Q ss_conf 985166634468999999999986406-8998738998477345665532454115788999999999998829415-88 Q Fun_Sc_NP_0140 107 ILLDWTLNDQKLWLNELSYAFNKIKQL-NDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSL-FY 184 (312) Q Consensus 107 iLLDWs~~Dp~~Wlr~Lr~~~~~L~~l-~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGASL-iY 184 (312) + +..++..+-+ +..|+..+++. +.+.++++|..|+| |+.++.. -..-.+.+|-++|+-- |- T Consensus 83 y----dit~~~Sf~~-l~~w~~~i~~~~~~~~~ivlVGNK~D----l~~~r~V--------~~~~~~~~a~~~~~~~~~E 145 (165) T cd01864 83 Y----DITRRSSFES-VPHWIEEVEKYGASNVVLLLIGNKCD----LEEQREV--------LFEEACTLAEKNGMLAVLE 145 (165) T ss_pred E----ECCCHHHHHH-HHHHHHHHHHCCCCCCEEEEEECCCC----CCCCCCC--------CHHHHHHHHHHCCCCEEEE T ss_conf 8----7599779999-99988889851698957999724211----0003554--------5789999999649948999 Q ss_pred ECCCCCHHHHHHHHHHHHHHHHHHCC Q ss_conf 52565313555667788887530012 Q Fun_Sc_NP_0140 185 ICEDHTEEKREEAQRLKYQELLKHFC 210 (312) Q Consensus 185 ts~ts~~~~kn~~~~l~y~~L~~h~l 210 (312) | |+++..|-...+.+ ++..+ T Consensus 146 ~---SAk~~~nv~e~F~~---la~~i 165 (165) T cd01864 146 T---SAKESQNVEEAFLL---MATEL 165 (165) T ss_pred E---EECCCCCHHHHHHH---HHHHC T ss_conf 7---40489898899999---99829 No 80 >e2atva1 c.37.1.8 (A:5-172) Ras-like estrogen-regulated growth inhibitor, RERG {Human (Homo sapiens) [TaxID:9606]} Probab=97.11 E-value=0.22 Score=30.64 Aligned_columns=167 Identities=11% Q ss_pred CCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCCCC Q ss_conf 64438997598331799999851477865566557502563356212133268899860785435887887718778782 Q Fun_Sc_NP_0140 24 ATITAIIYSPSSKTLHQFINICFPEGSNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHSSKV 103 (312) Q Consensus 24 ~~k~~lilg~~~~~~~~fi~~l~~~~~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s~~~ 103 (312) ++..++++|..+.||++|++++ .+...+.+..+--.......-. -++..+.+.+.+.+..........++ +.-. T Consensus 1 ~eiKI~iiG~~~vGKSsli~~~--~~~~~~~~~~~t~~~~~~~~~~-~~~~~~~~~i~d~~g~~~~~~~~~~~---~~~d 74 (168) T e2atva1 1 AEVKLAIFGRAGVGKSALVVRF--LTKRFIWEYDPTLESTYRHQAT-IDDEVVSMEILDTAGQEDTIQREGHM---RWGE 74 (168) T ss_pred CCEEEEEEECCCCCHHHHHHHH--HCCCCCCCCCCCEEEEEEEEEE-ECCEEEEEEEEEECCCHHHHHHHHHH---CCCC T ss_conf 9268999807998799999998--6381167625623666789997-56907999998620630466666541---1782 Q ss_pred EEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEE Q ss_conf 79998516663446899999999998640689987389984773456655324541157889999999999988294158 Q Fun_Sc_NP_0140 104 RWLILLDWTLNDQKLWLNELSYAFNKIKQLNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSLF 183 (312) Q Consensus 104 l~ViLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGASLi 183 (312) -+++..|-+..+....+.....++....... ..+++||+.|+| |+.+. ....++. +.+|-++|+..+ T Consensus 75 ~~ilv~d~~~~~S~~~~~~~~~~i~~~~~~~-~~piiivgnK~D----l~~~~-~i~~~e~-------~~~~~~~~~~~~ 141 (168) T e2atva1 75 GFVLVYDITDRGSFEEVLPLKNILDEIKKPK-NVTLILVGNKAD----LDHSR-QVSTEEG-------EKLATELACAFY 141 (168) T ss_pred EEEEEEEECCCCCHHHHHHHHHHHHHHCCCC-CCEEEEEEECCC----CCCCC-CCCHHHH-------HHHHHHCCCCEE T ss_conf 7999986448565668889999988631899-978999971356----44346-6798999-------999996499499 Q ss_pred EECCCCCHHHH-HHHHHHHHHHHHHHCCCCCCC Q ss_conf 85256531355-566778888753001247787 Q Fun_Sc_NP_0140 184 YICEDHTEEKR-EEAQRLKYQELLKHFCEDRDM 215 (312) Q Consensus 184 Yts~ts~~~~k-n~~~~l~y~~L~~h~l~~~~~ 215 (312) .+ |++... |-...+.. ++..+..+.. T Consensus 142 e~---Sa~~g~gnv~e~f~~---l~~~i~~~~~ 168 (168) T e2atva1 142 EC---SACTGEGNITEIFYE---LCREVRRRRM 168 (168) T ss_pred EE---EECCCCCCHHHHHHH---HHHHHHHCCC T ss_conf 99---722598367899999---9999986059 No 81 >d1m7ba_ c.37.1.8 (A:) RhoE (RND3) {Mouse (Mus musculus)} Probab=97.11 E-value=0.077 Score=33.32 Aligned_columns=171 Identities=6% Q ss_pred EEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCE-EEEEEEEECCCHHHHHHHHHHHCCCC-CCCEE Q ss_conf 89975983317999998514778655665575025633562121332-68899860785435887887718778-78279 Q Fun_Sc_NP_0140 28 AIIYSPSSKTLHQFINICFPEGSNSILDTTLINYATIGWTNDLKENY-SVDVYTLIRNTDDALDLLKPFLQEHS-SKVRW 105 (312) Q Consensus 28 ~lilg~~~~~~~~fi~~l~~~~~e~~~~~~~L~y~y~~v~~d~~d~~-R~~vy~L~~~~~~~~~LLkp~L~~~s-~~~l~ 105 (312) ++++|+.+.||++|+.++ -+.+.+.+..+-........-...+.. ++.+|-..|..... .+....- .-..+ T Consensus 5 I~iiG~~~vGKTsli~~~--~~~~f~~~~~~t~~~~~~~~~~~~~~~~~~~i~D~~g~~~~~-----~~~~~~~~~~d~~ 77 (179) T d1m7ba_ 5 IVVVGDSQCGKTALLHVF--AKDCFPENYVPTVFENYTASFEIDTQRIELSLWDTSGSPYYD-----NVRPLSYPDSDAV 77 (179) T ss_dssp EEEEESTTSSHHHHHHHH--HHSCCCSSCCCCSEEEEEEEEECSSCEEEEEEEEECCSGGGT-----TTGGGGCTTCSEE T ss_pred EEEEECCCCCHHHHHHHH--HCCCCCCCCCCEEEEEEEEEEECCCCCCEEEEECCCCCCCCC-----HHHHHHHCCCCEE T ss_conf 999706998789999998--628236663433676213432013311026861144321000-----0005663278657 Q ss_pred EEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEE Q ss_conf 99851666344689999999999864068998738998477345665532454115788999999999998829415885 Q Fun_Sc_NP_0140 106 LILLDWTLNDQKLWLNELSYAFNKIKQLNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSLFYI 185 (312) Q Consensus 106 ViLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGASLiYt 185 (312) |+.-|.+ |+..+-.....|...++....+.++++|+.|+|--..-......-....-..-..-.+.++-.+|+..++- T Consensus 78 iivydv~--~~~Sf~~i~~~~~~~~~~~~~~~piilvgnK~DL~~~~~~~~~~~~~~~~~Vs~~e~~~la~~~~~~~y~E 155 (179) T d1m7ba_ 78 LICFDIS--RPETLDSVLKKWKGEIQEFCPNTKMLLVGCKSDLRTDVSTLVELSNHRQTPVSYDQGANMAKQIGAATYIE 155 (179) T ss_dssp EEEEETT--CHHHHHHHHHTHHHHHHHHCTTCEEEEEEECGGGGGCHHHHHHHHTTTCCCCCHHHHHHHHHHHTCSEEEE T ss_pred EEEEECC--CCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEE T ss_conf 9998068--60357889887777776402674157875266632103456654430376589899999999708952898 Q ss_pred CCCCCHHH-HHHHHHHHHHHHHH Q ss_conf 25653135-55667788887530 Q Fun_Sc_NP_0140 186 CEDHTEEK-REEAQRLKYQELLK 207 (312) Q Consensus 186 s~ts~~~~-kn~~~~l~y~~L~~ 207 (312) |.....++ -+..-...-.+.+. T Consensus 156 ~SA~t~~n~v~~~F~~~~~~~~~ 178 (179) T d1m7ba_ 156 CSALQSENSVRDIFHVATLACVN 178 (179) T ss_dssp CBTTTBHHHHHHHHHHHHHHHHT T ss_pred EEECCCCCHHHHHHHHHHHHHHC T ss_conf 75036884089999999999843 No 82 >cd00157 Rho Rho (Ras homology) family. Members of the Rho family include RhoA, Cdc42, Rac, Rnd, Wrch1, RhoBTB, and Rop. There are 22 human Rho family members identified currently. These proteins are all involved in the reorganization of the actin cytoskeleton in response to external stimuli. They also have roles in cell transformation by Ras in cytokinesis, in focal adhesion formation and in the stimulation of stress-activated kinase. These various functions are controlled through distinct effector proteins and mediated through a GTP-binding/GTPase cycle involving three classes of regulating proteins: GAPs (GTPase-activating proteins), GEFs (guanine nucleotide exchange factors), and GDIs (guanine nucleotide dissociation inhibitors). Most Rho proteins contain a lipid modification site at the C-terminus, with a typical sequence motif CaaX, where a = an aliphatic amino acid and X = any amino acid. Lipid binding is essential for membrane attachment, a key feature of most Rho protein Probab=97.10 E-value=0.08 Score=33.19 Aligned_columns=163 Identities=6% Q ss_pred EEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCCCCEEEE Q ss_conf 89975983317999998514778655665575025633562121332688998607854358878877187787827999 Q Fun_Sc_NP_0140 28 AIIYSPSSKTLHQFINICFPEGSNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHSSKVRWLI 107 (312) Q Consensus 28 ~lilg~~~~~~~~fi~~l~~~~~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s~~~l~Vi 107 (312) ++++|+.+-|||+|+.+.....-.+-...+....+...+.-+ .....+.+|=..| ...+-.+.+.+. +.-.-+++ T Consensus 3 i~liGd~~VGKTsli~r~~~~~f~~~~~~Ti~~~~~~~i~~~-~~~~~l~iwDt~G-~e~~~~l~~~~~---~~a~~~il 77 (171) T cd00157 3 IVVVGDGAVGKTCLLISYTTGKFPTEYVPTVFDNYSATVTVD-GKQVNLGLWDTAG-QEEYDRLRPLSY---PNTDVFLI 77 (171) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEEC-CEEEEEEEEECCC-CHHHHHHHHHHH---CCCCEEEE T ss_conf 899807995489999998638316653432652145578755-6799999960677-434678989873---28985899 Q ss_pred EECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECC Q ss_conf 85166634468999999999986406899873899847734566553245411578899999999999882941588525 Q Fun_Sc_NP_0140 108 LLDWTLNDQKLWLNELSYAFNKIKQLNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSLFYICE 187 (312) Q Consensus 108 LLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGASLiYts~ 187 (312) .-|-+. +...-+.+..|+..++....+.++++|..|+|-.+.=+..- ...+.+=-.-.+-.+.+|-.+|+..+|- T Consensus 78 vydit~--~~Sf~~~~~~w~~~i~~~~~~~piilVgnK~DL~~~~~~~~-~~~~~~r~Vs~~e~~~~a~~~~~~~f~E-- 152 (171) T cd00157 78 CFSVDS--PSSFENVKTKWIPEIRHYCPNVPIILVGTKIDLRDDENTLK-KLEKGKEPITPEEGEKLAKEIGAIGYME-- 152 (171) T ss_pred EEECCC--HHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHH-HHHCCCCCCCHHHHHHHHHHCCCCEEEE-- T ss_conf 971688--65899999998999998468956999853744212112232-2101357789899999999739952788-- Q ss_pred CCCHHHHHHHHHH Q ss_conf 6531355566778 Q Fun_Sc_NP_0140 188 DHTEEKREEAQRL 200 (312) Q Consensus 188 ts~~~~kn~~~~l 200 (312) +|+++..|-..++ T Consensus 153 tSAktg~nV~e~F 165 (171) T cd00157 153 CSALTQEGVKEVF 165 (171) T ss_pred EECCCCCCHHHHH T ss_conf 7504898878999 No 83 >2f9l_A RAB11B, member RAS oncogene family; RAB11B GTPase, vesicle transport; HET: GDP; 1.55A {Homo sapiens} SCOP: c.37.1.8 Probab=97.10 E-value=0.2 Score=30.91 Aligned_columns=177 Identities=11% Q ss_pred EEEECCCCHHHHHHHHHHCC-CCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCCCCEEE Q ss_conf 89975983317999998514-77865566557502563356212133268899860785435887887718778782799 Q Fun_Sc_NP_0140 28 AIIYSPSSKTLHQFINICFP-EGSNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHSSKVRWL 106 (312) Q Consensus 28 ~lilg~~~~~~~~fi~~l~~-~~~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s~~~l~V 106 (312) ++|+|..+.||++|+.++.. .-.+...+..+.++....+..+ .+...+..|--.+......-....+ +....++ T Consensus 8 i~ivG~~~vGKTsli~~~~~~~~~~~~~~t~~~~~~~~~~~~~-~~~~~~~i~d~~~~~~~~~~~~~~~----~~~~~~i 82 (199) T 2f9l_A 8 VVLIGDSGVGKSNLLSRFTRNEFNLESKSTIGVEFATRSIQVD-GKTIKAQIWDTAGQERYRRITSAYY----RGAVGAL 82 (199) T ss_dssp EEEESSTTSSHHHHHHHHHHSCCCC---CCCSCEEEEEEEEET-TEEEEEEEEECSSGGGTTCCCHHHH----TTCSEEE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEEE-EEEEEEEEECCCCCCHHHHHHHHHH----CCCCEEE T ss_conf 8998269976899999986283367645614544565554310-0356556524532101235667650----4783799 Q ss_pred EEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEC Q ss_conf 98516663446899999999998640689987389984773456655324541157889999999999988294158852 Q Fun_Sc_NP_0140 107 ILLDWTLNDQKLWLNELSYAFNKIKQLNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSLFYIC 186 (312) Q Consensus 107 iLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGASLiYts 186 (312) +..|-+. +...-..-..+-...+....+.++++|.+|+|....-+-.. +-.+.++-.+++..+.+ T Consensus 83 ~v~d~~~--~~s~~~~~~~~~~~~~~~~~~~piilVgnK~Dl~~~~~~~~------------~e~~~~a~~~~~~~~e~- 147 (199) T 2f9l_A 83 LVYDIAK--HLTYENVERWLKELRDHADSNIVIMLVGNKSDLRHLRAVPT------------DEARAFAEKNNLSFIET- 147 (199) T ss_dssp EEEETTC--HHHHHTHHHHHHHHHHHSCTTCEEEEEEECTTCGGGCCSCH------------HHHHHHHHHTTCEEEEC- T ss_pred EEECCCC--HHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCH------------HHHHHHHHHCCCCEEEE- T ss_conf 9702678--66889999889999983489977999961057220014607------------78889999738973788- Q ss_pred CCCCHHHHHHHHHHH-HHHHHHHCCCCCCCCCCCCEECCCC Q ss_conf 565313555667788-8875300124778775224011563 Q Fun_Sc_NP_0140 187 EDHTEEKREEAQRLK-YQELLKHFCEDRDMKDHIEMVTRSE 226 (312) Q Consensus 187 ~ts~~~~kn~~~~l~-y~~L~~h~l~~~~~~~~a~vverd~ 226 (312) |++...|...++. -...+.......+.........+.. T Consensus 148 --Saktg~~v~elf~~l~~~i~~~~~~~~~~~~~~~~~~~~ 186 (199) T 2f9l_A 148 --SALDSTNVEEAFKNILTEIYRIVSQKQIADRAAHDESPG 186 (199) T ss_dssp --CTTTCTTHHHHHHHHHHHHHHHHHTSCCC---------- T ss_pred --EECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC T ss_conf --723787888999999999998865200111123565678 No 84 >cd04119 RJL RJL (RabJ-Like) subfamily. RJLs are found in many protists and as chimeras with C-terminal DNAJ domains in deuterostome metazoa. They are not found in plants, fungi, and protostome metazoa, suggesting a horizontal gene transfer between protists and deuterostome metazoa. RJLs lack any known membrane targeting signal and contain a degenerate phosphate/magnesium-binding 3 (PM3) motif, suggesting an impaired ability to hydrolyze GTP. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Probab=97.10 E-value=0.16 Score=31.45 Aligned_columns=159 Identities=14% Q ss_pred EEEECCCCHHHHHHHHHHCCCC-CCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCCCCEEE Q ss_conf 8997598331799999851477-865566557502563356212133268899860785435887887718778782799 Q Fun_Sc_NP_0140 28 AIIYSPSSKTLHQFINICFPEG-SNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHSSKVRWL 106 (312) Q Consensus 28 ~lilg~~~~~~~~fi~~l~~~~-~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s~~~l~V 106 (312) ++++|+.+-||++++.+..... .+.+.+..|.+|....+.-+ ....++.+|=..|.... ..+.+.+. +.-.-++ T Consensus 3 ivivGd~~vGKTsli~r~~~~~f~~~y~~Tig~~~~~k~i~~~-~~~~~l~iwDtaG~e~~-~~~~~~~~---~~a~~~i 77 (168) T cd04119 3 VISMGNSGVGKSCIIKRYCEGRFVSKYLPTIGIDYGVKKVSVR-NKEVRVNFFDLSGHPEY-LEVRNEFY---KDTQGVL 77 (168) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEEC-CEEEEEEEEECCCCHHH-HHHHHHHH---CCCCEEE T ss_conf 8998079854899998877180166536503555556788887-94899998606898125-78878872---3999389 Q ss_pred EEECCCCCCHHHHHHHHHHHHHHHHC------CCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCC Q ss_conf 98516663446899999999998640------689987389984773456655324541157889999999999988294 Q Fun_Sc_NP_0140 107 ILLDWTLNDQKLWLNELSYAFNKIKQ------LNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDS 180 (312) Q Consensus 107 iLLDWs~~Dp~~Wlr~Lr~~~~~L~~------l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGA 180 (312) +.-|=+. +...-+ +..|+..+++ .....++++|-.|+|-...-+-.. +-.+.+|-.+|+ T Consensus 78 lvydit~--~~Sf~~-i~~w~~~~~~~~~~~~~~~~~~iilvGNK~Dl~~~r~V~~------------~~~~~~a~~~~~ 142 (168) T cd04119 78 LVYDVTD--RQSFEA-LDSWLKEMKQEGGPHGNMENIVVVVCANKIDLTKHRAVSE------------DEGRLWAESKGF 142 (168) T ss_pred EEEECCC--HHHHHH-HHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCH------------HHHHHHHHHCCC T ss_conf 9985699--778999-9999999998605556668747999705323323576798------------999999996499 Q ss_pred EEEEECCCCCHHHHHHHHHHHHHHHHHHCCCC Q ss_conf 15885256531355566778888753001247 Q Fun_Sc_NP_0140 181 SLFYICEDHTEEKREEAQRLKYQELLKHFCED 212 (312) Q Consensus 181 SLiYts~ts~~~~kn~~~~l~y~~L~~h~l~~ 212 (312) ..|-| |+++..|-...+.. ++..+.+ T Consensus 143 ~~~E~---SAk~~~nV~e~F~~---l~~~i~d 168 (168) T cd04119 143 KYFET---SACTGEGVNEMFQT---LFSSIVD 168 (168) T ss_pred EEEEE---ECCCCCCHHHHHHH---HHHHHCC T ss_conf 19999---71589787899999---9998559 No 85 >1z0j_A RAB-22, RAS-related protein RAB-22A; RAB GTPase, RAB22 GTPase, endosomal trafficking; HET: GTP; 1.32A {Mus musculus} SCOP: c.37.1.8 Probab=97.09 E-value=0.57 Score=28.15 Aligned_columns=153 Identities=7% Q ss_pred EEEECCCCHHHHHHHHHHCC-CCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCCCCEEE Q ss_conf 89975983317999998514-77865566557502563356212133268899860785435887887718778782799 Q Fun_Sc_NP_0140 28 AIIYSPSSKTLHQFINICFP-EGSNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHSSKVRWL 106 (312) Q Consensus 28 ~lilg~~~~~~~~fi~~l~~-~~~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s~~~l~V 106 (312) ++++|..+.||++|++++.. .-...+.++.+..+....+..+ ....++..|-..|......-.-..+-+++ -++ T Consensus 9 I~iiG~~~vGKSsLi~~l~~~~~~~~~~~t~~~~~~~~~~~~~-~~~~~~~~~d~~g~~~~~~~~~~~~~~~~----~~i 83 (170) T 1z0j_A 9 VCLLGDTGVGKSSIMWRFVEDSFDPNINPTIGASFMTKTVQYQ-NELHKFLIWDTAGLERFRALAPMYYRGSA----AAI 83 (170) T ss_dssp EEEECCTTSSHHHHHHHHHHSCCCTTCCCCCSEEEEEEEEEET-TEEEEEEEEEECCSGGGGGGTHHHHTTCS----EEE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCC-CEEEEEEECCCCCCCHHHHHHHHHHCCCC----EEE T ss_conf 8998079987899999986481355523200000111001001-40354431026662012121013203665----079 Q ss_pred EEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEC Q ss_conf 98516663446899999999998640689987389984773456655324541157889999999999988294158852 Q Fun_Sc_NP_0140 107 ILLDWTLNDQKLWLNELSYAFNKIKQLNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSLFYIC 186 (312) Q Consensus 107 iLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGASLiYts 186 (312) ++.|-+ |+..+-..-+.+-........+-++++|+.|+| |+.+.....++ .+.++-.+++..+.+ T Consensus 84 ~v~d~~--~~~s~~~~~~~~~~~~~~~~~~~piilv~nK~D----l~~~~~~~~~~--------~~~~~~~~~~~~~e~- 148 (170) T 1z0j_A 84 IVYDIT--KEETFSTLKNWVRELRQHGPPSIVVAIAGNKCD----LTDVREVMERD--------AKDYADSIHAIFVET- 148 (170) T ss_dssp EEEETT--CHHHHHHHHHHHHHHHHHSCTTSEEEEEEECTT----CGGGCCSCHHH--------HHHHHHHTTCEEEEC- T ss_pred EEEECC--CCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCC----HHHHHHHHHHH--------HHHHHHHCCCEEEEE- T ss_conf 997435--511343233343221103799846999833430----01332013578--------899999549859998- Q ss_pred CCCCHHHHHHHHHHHH Q ss_conf 5653135556677888 Q Fun_Sc_NP_0140 187 EDHTEEKREEAQRLKY 202 (312) Q Consensus 187 ~ts~~~~kn~~~~l~y 202 (312) |++...|...++.. T Consensus 149 --Sa~~~~~i~elf~~ 162 (170) T 1z0j_A 149 --SAKNAININELFIE 162 (170) T ss_dssp --BTTTTBSHHHHHHH T ss_pred --ECCCCCCHHHHHHH T ss_conf --52689788899999 No 86 >cd04112 Rab26 Rab26 subfamily. First identified in rat pancreatic acinar cells, Rab26 is believed to play a role in recruiting mature granules to the plasma membrane upon beta-adrenergic stimulation. Rab26 belongs to the Rab functional group III, which are considered key regulators of intracellular vesicle transport during exocytosis. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site at the C-terminus, with sequence motifs CC, CXC, or CCX. Lipid binding is essential for membrane attachment, a key feature of most Rab proteins. Probab=97.07 E-value=0.2 Score=30.85 Aligned_columns=167 Identities=10% Q ss_pred EEEECCCCHHHHHHHHHHCCCCC--CCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCCCCEE Q ss_conf 89975983317999998514778--6556655750256335621213326889986078543588788771877878279 Q Fun_Sc_NP_0140 28 AIIYSPSSKTLHQFINICFPEGS--NSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHSSKVRW 105 (312) Q Consensus 28 ~lilg~~~~~~~~fi~~l~~~~~--e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s~~~l~ 105 (312) ++++|+.+-|||+|+.+.....- +.+....|..|....+.-+ ....++.+|=-.|- +.+..+.+.....-.- + T Consensus 3 Iv~iGd~~VGKTsli~r~~~~~f~~~~~~~Tig~~~~~k~i~~~-~~~i~l~iwDtaGq-e~~~~l~~~yy~~a~~---~ 77 (191) T cd04112 3 VMLLGDSGVGKTCLLVRFKDGAFLNGNFIATVGIDFRNKVVTVD-GVKVKLQIWDTAGQ-ERFRSVTHAYYRDAHA---L 77 (191) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEEEC-CEEEEEEEEECCCC-HHHHHHHHHHHCCCCE---E T ss_conf 89982699548999988762822587634211100367789887-93899998755887-0124553666138977---9 Q ss_pred EEEECCCCCCHHHHHHHHHHHHHHHHCC-CCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEE Q ss_conf 9985166634468999999999986406-899873899847734566553245411578899999999999882941588 Q Fun_Sc_NP_0140 106 LILLDWTLNDQKLWLNELSYAFNKIKQL-NDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSLFY 184 (312) Q Consensus 106 ViLLDWs~~Dp~~Wlr~Lr~~~~~L~~l-~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGASLiY 184 (312) +|.-|-+. +..+-. +..|+..+++. ..+.++++|-.|+| |+.++ .-+.++. +.++-.+|+..|- T Consensus 78 iivyDit~--~~Sf~~-i~~w~~~i~~~~~~~~~ivlVGNK~D----L~~~r-~V~~~e~-------~~~a~~~~~~~~E 142 (191) T cd04112 78 LLLYDITN--KASFDN-IRAWLTEIKEYAQEDVVIMLLGNKAD----MSGER-VVKREDG-------ERLAKEYGVPFME 142 (191) T ss_pred EEEEECCC--HHHHHH-HHHHHHHHHHHCCCCCEEEEEEECCC----CCCCC-CCCHHHH-------HHHHHHCCCCEEE T ss_conf 99987799--789999-99999988852699948999863277----63225-5388999-------9999966995999 Q ss_pred ECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC Q ss_conf 525653135556677888875300124778775224 Q Fun_Sc_NP_0140 185 ICEDHTEEKREEAQRLKYQELLKHFCEDRDMKDHIE 220 (312) Q Consensus 185 ts~ts~~~~kn~~~~l~y~~L~~h~l~~~~~~~~a~ 220 (312) | |+++..|-..++.. ++..+..+....+.. T Consensus 143 t---SAk~~~nI~e~F~~---l~~~i~~~~~~~~~~ 172 (191) T cd04112 143 T---SAKTGLNVELAFTA---VAKELKHRKYEQPDE 172 (191) T ss_pred E---ECCCCCCHHHHHHH---HHHHHHHHCCCCCCC T ss_conf 9---62589888899999---999999723788876 No 87 >1zd9_A ADP-ribosylation factor-like 10B; transport protein, GDP-binding, membrane trafficking, structural genomics, structural genomics consortium, SGC; HET: GDP; 1.70A {Homo sapiens} SCOP: c.37.1.8 Probab=97.06 E-value=0.082 Score=33.15 Aligned_columns=173 Identities=12% Q ss_pred CCCCCCCCC----CCCEEEEECCCCHHHHHHHHHHCC-CCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHH Q ss_conf 011465536----644389975983317999998514-778655665575025633562121332688998607854358 Q Fun_Sc_NP_0140 15 ESTINSTET----ATITAIIYSPSSKTLHQFINICFP-EGSNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDAL 89 (312) Q Consensus 15 ~~~~~~k~~----~~k~~lilg~~~~~~~~fi~~l~~-~~~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~ 89 (312) +..+++..| ...-++++|..+.|||+|++++.. .-.+.+.+..+..+..+.+ ++.++.+|-..| ...+. T Consensus 8 ~~~~s~~~p~g~~~~~kI~ivG~~~~GKTsLi~~l~~~~~~~~~~~Ti~~~~~~i~~-----~~~~~~i~D~~G-~~~~~ 81 (188) T 1zd9_A 8 HHHSSGLVPRGSKEEMELTLVGLQYSGKTTFVNVIASGQFNEDMIPTVGFNMRKITK-----GNVTIKLWDIGG-QPRFR 81 (188) T ss_dssp -----------CCEEEEEEEECSTTSSHHHHHHHHHHSCCCCSCCCCCSEEEEEEEE-----TTEEEEEEEECC-SHHHH T ss_pred CCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCCCCCCEEEEECEEEECCC-----CEEEEEEEEECC-CCCCC T ss_conf 333557788877760589998259987899999985680222410134020320357-----537998863023-00012 Q ss_pred HHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHH--HCCCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHH Q ss_conf 87887718778782799985166634468999999999986--4068998738998477345665532454115788999 Q Fun_Sc_NP_0140 90 DLLKPFLQEHSSKVRWLILLDWTLNDQKLWLNELSYAFNKI--KQLNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFI 167 (312) Q Consensus 90 ~LLkp~L~~~s~~~l~ViLLDWs~~Dp~~Wlr~Lr~~~~~L--~~l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfI 167 (312) ++.+..+ +.-..++++.|=+ |+.. +..++.|+..+ .....+.+++||+.|+|.....+.+ ++. T Consensus 82 ~~~~~~~---~~~~~~ilv~d~~--d~~s-~~~~~~~~~~i~~~~~~~~~piiiv~nK~Dl~~~~~~~---------~i~ 146 (188) T 1zd9_A 82 SMWERYC---RGVSAIVYMVDAA--DQEK-IEASKNELHNLLDKPQLQGIPVLVLGNKRDLPGALDEK---------ELI 146 (188) T ss_dssp TTHHHHH---TTCSEEEEEEETT--CGGG-HHHHHHHHHHHHTCGGGTTCCEEEEEECTTSTTCCCHH---------HHH T ss_pred CCCHHHH---CCCCCCCCCCCCC--CCCC-HHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHH---------HHH T ss_conf 2310121---1432101003553--2311-01245665543101111783477522004654547887---------899 Q ss_pred HHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCC Q ss_conf 99999999882941588525653135556677888875300124778 Q Fun_Sc_NP_0140 168 LQTLRSFCYFNDSSLFYICEDHTEEKREEAQRLKYQELLKHFCEDRD 214 (312) Q Consensus 168 qQ~LRtvcL~yGASLiYts~ts~~~~kn~~~~l~y~~L~~h~l~~~~ 214 (312) ...-..++-.++...+.+ |++...+...++.. +++..-.+. T Consensus 147 ~~~~~~~~~~~~~~~~~~---Sa~~g~gv~e~~~~---li~~i~~~~ 187 (188) T 1zd9_A 147 EKMNLSAIQDREICCYSI---SCKEKDNIDITLQW---LIQHSKSRR 187 (188) T ss_dssp HHTTGGGCCSSCEEEEEC---CTTTCTTHHHHHHH---HHHTCC--- T ss_pred HHHHHHHHHHCCCEEEEE---ECCCCCCHHHHHHH---HHHHHHHCC T ss_conf 998888875179669998---52478788999999---999998506 No 88 >cd04123 Rab21 Rab21 subfamily. The localization and function of Rab21 are not clearly defined, with conflicting data reported. Rab21 has been reported to localize in the ER in human intestinal epithelial cells, with partial colocalization with alpha-glucosidase, a late endosomal/lysosomal marker. More recently, Rab21 was shown to colocalize with and affect the morphology of early endosomes. In Dictyostelium, GTP-bound Rab21, together with two novel LIM domain proteins, LimF and ChLim, has been shown to regulate phagocytosis. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site Probab=97.06 E-value=0.22 Score=30.65 Aligned_columns=158 Identities=10% Q ss_pred EEEECCCCHHHHHHHHHHCC-CCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCCCCEEE Q ss_conf 89975983317999998514-77865566557502563356212133268899860785435887887718778782799 Q Fun_Sc_NP_0140 28 AIIYSPSSKTLHQFINICFP-EGSNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHSSKVRWL 106 (312) Q Consensus 28 ~lilg~~~~~~~~fi~~l~~-~~~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s~~~l~V 106 (312) ++++|+.+.|||+|+.+... .-.+.+....+.++....+.-+ +.++.+-+.+.+..+-..-+.+..-.++.-..+| T Consensus 3 i~~iGd~~vGKTsli~r~~~~~f~~~~~~ti~~~~~~k~i~~~---~~~~~l~iwDt~G~~~~~~~~~~~~~~a~~~ilv 79 (162) T cd04123 3 VVLLGEGRVGKTSLVLRYVENKFNEKHESTTQASFFQKTVNIG---GKRIDLAIWDTAGQERYHALGPIYYRDADGAILV 79 (162) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECC---CCEEEEEEEECCCCHHHHHHHHHHHCCCCEEEEE T ss_conf 8998269965899999986281177645411244135533159---9389999730787502356657661489868999 Q ss_pred EEECCCCCCHHHHHHHHHHHHHHHHC-CCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEE Q ss_conf 98516663446899999999998640-68998738998477345665532454115788999999999998829415885 Q Fun_Sc_NP_0140 107 ILLDWTLNDQKLWLNELSYAFNKIKQ-LNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSLFYI 185 (312) Q Consensus 107 iLLDWs~~Dp~~Wlr~Lr~~~~~L~~-l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGASLiYt 185 (312) + |-+. +..+-+. +.|+..++. .+.+.++++|..|+| |++++..-.++ .+.+|-++|+..+-+ T Consensus 80 y--dit~--~~Sf~~i-~~w~~~i~~~~~~~~piilVGNK~D----l~~~r~V~~~~--------~~~~a~~~~~~~~E~ 142 (162) T cd04123 80 Y--DITD--ADSFQKV-KKWIKELKQMRGNNISLVIVGNKID----LERQRVVSKSE--------AEEYAKSVGAKHFET 142 (162) T ss_pred E--ECCC--HHHHHHH-HHHHHHHHHHCCCCCEEEEEEEHHH----HHHHCCCCHHH--------HHHHHHHCCCCEEEE T ss_conf 4--2798--7789999-9999989973189965999840023----12102547789--------999999649938999 Q ss_pred CCCCCHHHHHHHHHHHHHHHHHHCCC Q ss_conf 25653135556677888875300124 Q Fun_Sc_NP_0140 186 CEDHTEEKREEAQRLKYQELLKHFCE 211 (312) Q Consensus 186 s~ts~~~~kn~~~~l~y~~L~~h~l~ 211 (312) |+++..|-...+.. ++..+. T Consensus 143 ---Sak~~~nv~e~F~~---l~~~il 162 (162) T cd04123 143 ---SAKTGKGIEELFLS---LAKRMI 162 (162) T ss_pred ---ECCCCCCHHHHHHH---HHHHHC T ss_conf ---71589787899999---999829 No 89 >2fol_A RAS-related protein RAB-1A; G-protein, GTP analogue, structural genomics, struct URAL genomics consortium, SGC, structural genomics consortium; HET: GDP; 2.63A {Homo sapiens} SCOP: c.37.1.8 Probab=97.05 E-value=0.11 Score=32.44 Aligned_columns=172 Identities=8% Q ss_pred CCCCCCCCCC-------EEEEECCCCHHHHHHHHHHCC-CCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHH Q ss_conf 1465536644-------389975983317999998514-77865566557502563356212133268899860785435 Q Fun_Sc_NP_0140 17 TINSTETATI-------TAIIYSPSSKTLHQFINICFP-EGSNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDA 88 (312) Q Consensus 17 ~~~~k~~~~k-------~~lilg~~~~~~~~fi~~l~~-~~~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~ 88 (312) .+++-.|.+. .++++|..+.|||+|+.++.. .-.+.+-+..+..+....+..+ +..+.+.+.+.+.... T Consensus 10 ~~~~~~~~~~~~~~~~~KI~vvG~~~vGKTSLi~~l~~~~~~~~~~~t~~~~~~~~~~~~~---~~~~~l~i~D~~g~~~ 86 (191) T 2fol_A 10 HSSGLVPRGSPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELD---GKTIKLQIWDTAGQER 86 (191) T ss_dssp ------------CCEEEEEEEEECTTSCHHHHHHHHHHCCCCSSCCSCCSSSCEEEEEEET---TEEEEEEEEC------ T ss_pred CCCCCCCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEEC---EEEEEEEEEECCCCCH T ss_conf 4677798999782415789998179987999999986582256524334404789997401---0589999851478422 Q ss_pred HHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHH Q ss_conf 88788771877878279998516663446899999999998640689987389984773456655324541157889999 Q Fun_Sc_NP_0140 89 LDLLKPFLQEHSSKVRWLILLDWTLNDQKLWLNELSYAFNKIKQLNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFIL 168 (312) Q Consensus 89 ~~LLkp~L~~~s~~~l~ViLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIq 168 (312) .....-..-..-.-++++.|-+ |+...-..-..+-...+....+.+++||.+|+|....-+-+. T Consensus 87 --~~~~~~~~~~~ad~iI~v~d~~--d~~s~~~~~~~~~~~~~~~~~~~~iiiVgnK~Dl~~~~~v~~------------ 150 (191) T 2fol_A 87 --FRTITSSYYRGAHGIIVVYDVT--DQESFNNVKQWLQEIDRYASENVNKLLVGNKCDLTTKKVVDY------------ 150 (191) T ss_dssp ----------CTTCSEEEEEEETT--BHHHHHTHHHHHHHHHHSSCTTCEEEEEEECTTCTTTCCSCH------------ T ss_pred --HHHHHHHHCCCCCEEEEEEECC--CCHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCHHHCCCCCH------------ T ss_conf --3456787604887699985327--611213566666532011248825899730011101256678------------ Q ss_pred HHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCC Q ss_conf 999999988294158852565313555667788887530012477 Q Fun_Sc_NP_0140 169 QTLRSFCYFNDSSLFYICEDHTEEKREEAQRLKYQELLKHFCEDR 213 (312) Q Consensus 169 Q~LRtvcL~yGASLiYts~ts~~~~kn~~~~l~y~~L~~h~l~~~ 213 (312) +-.+.++-++|+..|-+ |+++..+...++.. +++.+..+ T Consensus 151 ~e~~~~~~~~~~~~~e~---Sa~~~~gi~elf~~---l~~~i~~r 189 (191) T 2fol_A 151 TTAKEFADSLGIPFLET---SAKNATNVEQSFMT---MAAEIKKR 189 (191) T ss_dssp HHHHHHHHHHTCCEEEC---BTTTTBSHHHHHHH---HHHHHHHH T ss_pred HHHHHHHHHCCCCEEEE---ECCCCCCHHHHHHH---HHHHHHHH T ss_conf 89999999659919999---61689788899999---99999984 No 90 >2bov_A RAla, RAS-related protein RAL-A; C3BOT, exoenzyme, RAla, GTPase, ribosylating toxin, GTP-binding, lipoprotein, prenylation; HET: GDP; 2.66A {Homo sapiens} Probab=97.05 E-value=0.44 Score=28.82 Aligned_columns=153 Identities=10% Q ss_pred EEEECCCCHHHHHHHHHHCC-CCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCCCCEEE Q ss_conf 89975983317999998514-77865566557502563356212133268899860785435887887718778782799 Q Fun_Sc_NP_0140 28 AIIYSPSSKTLHQFINICFP-EGSNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHSSKVRWL 106 (312) Q Consensus 28 ~lilg~~~~~~~~fi~~l~~-~~~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s~~~l~V 106 (312) ++++|+.+.|||+|+.++.. ...+.+.++.+-.|.+....++.+ .++..|-..|.-......-..+-..+ .++ T Consensus 17 I~iiG~~~vGKTsLi~~l~~~~~~~~~~~t~~~~~~~~~~~~~~~--~~l~i~d~~g~~~~~~~~~~~~~~~~----~~i 90 (206) T 2bov_A 17 VIMVGSGGVGKSALTLQFMYDEFVEDYEPTKADSYRKKVVLDGEE--VQIDILDTAGQEDYAAIRDNYFRSGE----GFL 90 (206) T ss_dssp EEEECSTTSSHHHHHHHHHHSCCCTTCCTTCCEEEEEEEEETTEE--EEEEEEECCCTTCCHHHHHHHHHHCS----EEE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEECCEE--EEEEEEECCCCCCCCCCCCCCCCCCC----EEE T ss_conf 999827998789999998628316752563045789999834748--99987302474311310000011220----112 Q ss_pred EEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEC Q ss_conf 98516663446899999999998640689987389984773456655324541157889999999999988294158852 Q Fun_Sc_NP_0140 107 ILLDWTLNDQKLWLNELSYAFNKIKQLNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSLFYIC 186 (312) Q Consensus 107 iLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGASLiYts 186 (312) +..|-+..+.--.++.+...+...+ .....++++|+.|+| |+.....-.++ ++.++-.+|+..|.+ T Consensus 91 ~v~d~~~~~s~~~~~~~~~~~~~~~-~~~~~piilv~nK~D----l~~~~~v~~~~--------~~~~~~~~~~~~~~~- 156 (206) T 2bov_A 91 CVFSITEMESFAATADFREQILRVK-EDENVPFLLVGNKSD----LEDKRQVSVEE--------AKNRAEQWNVNYVET- 156 (206) T ss_dssp EEEETTCHHHHHHHHHHHHHHHHHT-TCSCCCEEEEEECTT----CGGGCCSCHHH--------HHHHHHHHTCEEEEE- T ss_pred EEECCCCHHHHHHHHHHHHHHHHCC-CCCCCEEEEECCCCC----CHHCCCCCHHH--------HHHHHHHCCCCEEEE- T ss_conf 2211432001688998866643114-799707997147644----00104678899--------999999648955898- Q ss_pred CCCCHHHHHHHHHHHH Q ss_conf 5653135556677888 Q Fun_Sc_NP_0140 187 EDHTEEKREEAQRLKY 202 (312) Q Consensus 187 ~ts~~~~kn~~~~l~y 202 (312) |+....|....+.. T Consensus 157 --Sa~~~~~i~~~f~~ 170 (206) T 2bov_A 157 --SAKTRANVDKVFFD 170 (206) T ss_dssp --CTTTCTTHHHHHHH T ss_pred --EECCCCCHHHHHHH T ss_conf --60589888899999 No 91 >pfam00071 Ras Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices. Probab=97.05 E-value=0.2 Score=30.85 Aligned_columns=160 Identities=8% Q ss_pred EEEECCCCHHHHHHHHHHCC-CCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCCCCEEE Q ss_conf 89975983317999998514-77865566557502563356212133268899860785435887887718778782799 Q Fun_Sc_NP_0140 28 AIIYSPSSKTLHQFINICFP-EGSNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHSSKVRWL 106 (312) Q Consensus 28 ~lilg~~~~~~~~fi~~l~~-~~~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s~~~l~V 106 (312) ++++|+.+.|||+|+.++.. .-.+.+.+..+..+....+.-+ .....+..|-..| ...+..+.+-++.. -..++ T Consensus 2 i~viG~~~vGKTsli~r~~~~~f~~~~~~Ti~~~~~~k~v~~~-~~~~~l~i~Dt~g-~e~~~~~~~~~~~~---ad~~i 76 (162) T pfam00071 2 LVLVGDGGVGKSSLLIRFTQNKFPEEYIPTIGVDFYTKTIEVD-GKTVKLQIWDTAG-QERFRSLRPAYYRG---AQGFL 76 (162) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEEEC-CEEEEEEEEECCC-CCHHHHHHHHHCCC---CCEEE T ss_conf 7888179966899999986383276544201015789999873-6799999986699-80135675865048---98899 Q ss_pred EEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEC Q ss_conf 98516663446899999999998640689987389984773456655324541157889999999999988294158852 Q Fun_Sc_NP_0140 107 ILLDWTLNDQKLWLNELSYAFNKIKQLNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSLFYIC 186 (312) Q Consensus 107 iLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGASLiYts 186 (312) +.-|-+..+....++.....+..-.+ .+.++++|++|+|-...-+-.. +-.+.++-++|+..|.| T Consensus 77 lvfd~~~~~Sf~~i~~w~~~i~~~~~--~~~piilvgnK~Dl~~~~~i~~------------~e~~~~~~~~~~~y~e~- 141 (162) T pfam00071 77 LVYDITSRDSFENVKKWLEEILRHAD--ENVPIVLVGNKCDLEDQRVVST------------EEGEALAKELGLPFMET- 141 (162) T ss_pred EEEECCCHHHHHHHHHHHHHHHHHCC--CCCEEEEEEECCHHHHHCCCCH------------HHHHHHHHHCCCCEEEE- T ss_conf 99877997899999999999998459--9948999850420112116768------------89999999649959999- Q ss_pred CCCCHHHHHHHHHHHHHHHHHHCCCC Q ss_conf 56531355566778888753001247 Q Fun_Sc_NP_0140 187 EDHTEEKREEAQRLKYQELLKHFCED 212 (312) Q Consensus 187 ~ts~~~~kn~~~~l~y~~L~~h~l~~ 212 (312) |++...|-..++.. ++..+.. T Consensus 142 --Sak~g~gI~e~F~~---l~~~i~~ 162 (162) T pfam00071 142 --SAKTNTNVEEAFEE---LAREILK 162 (162) T ss_pred --ECCCCCCHHHHHHH---HHHHHHC T ss_conf --71479888899999---9999809 No 92 >2j0v_A RAC-like GTP-binding protein ARAC7; ROP9, atrac7, membrane, palmitate, RHO GTPase, abscisic acid signaling pathway; HET: GDP; 1.78A {Arabidopsis thaliana} Probab=97.03 E-value=0.16 Score=31.36 Aligned_columns=172 Identities=8% Q ss_pred EEEECCCCHHHHHHHHHHCCCC-CCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCCCCEEE Q ss_conf 8997598331799999851477-865566557502563356212133268899860785435887887718778782799 Q Fun_Sc_NP_0140 28 AIIYSPSSKTLHQFINICFPEG-SNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHSSKVRWL 106 (312) Q Consensus 28 ~lilg~~~~~~~~fi~~l~~~~-~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s~~~l~V 106 (312) ++++|..+.||++|+.++..+. .+.+.++.+..|......+. .++.+.+.+.+..+.-.-+....-.+.. .++ T Consensus 12 i~iiG~~~vGKTsli~~~~~~~~~~~~~~t~~~~~~~~~~~~~----~~~~l~i~d~~g~~~~~~~~~~~~~~ad--~~i 85 (212) T 2j0v_A 12 CVTVGDGAVGKTCMLICYTSNKFPTDYIPTVFDNFSANVAVDG----QIVNLGLWDTAGQEDYSRLRPLSYRGAD--IFV 85 (212) T ss_dssp EEEEESTTSSHHHHHHHHHHSCCCSSCCCSSCCCEEEEEECSS----CEEEEEEECCCCCCCCC--CCGGGTTCS--EEE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEECC----EEEEEEECCCCCCCCCHHHHHCCCCHHH--CCC T ss_conf 9998079977899999986383266635512677888766445----5665310125674200011100010110--133 Q ss_pred EEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCC---HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEE Q ss_conf 98516663446899999999998640689987389984773---456655324541157889999999999988294158 Q Fun_Sc_NP_0140 107 ILLDWTLNDQKLWLNELSYAFNKIKQLNDDNEFSVWCLNSG---EILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSLF 183 (312) Q Consensus 107 iLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~Dt~i~VVc~~sD---~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGASLi 183 (312) +..|-+ |+.++-..+..|...++....+.++++|..|+| .-..++.+...-..++ .+.++-.+|.-.+ T Consensus 86 ~v~d~~--~~~s~~~~~~~~~~~~~~~~~~~piiivgNK~Dl~~~~~~~~~~~~~v~~~e-------~~~~a~~~~~~~~ 156 (212) T 2j0v_A 86 LAFSLI--SKASYENVLKKWMPELRRFAPNVPIVLVGTKLDLRDDKGYLADHTNVITSTQ-------GEELRKQIGAAAY 156 (212) T ss_dssp EEEETT--CHHHHHHHHHTHHHHHHHHCTTCCEEEEEECHHHHTCHHHHHTCSSCCCHHH-------HHHHHHHHTCSEE T ss_pred CCCCCC--CHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHH-------HHHHHHHHCCCCE T ss_conf 443203--4233899999989998764068438998505673001122345553110888-------9999998418856 Q ss_pred EECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCC Q ss_conf 852565313555667788887530012477877522 Q Fun_Sc_NP_0140 184 YICEDHTEEKREEAQRLKYQELLKHFCEDRDMKDHI 219 (312) Q Consensus 184 Yts~ts~~~~kn~~~~l~y~~L~~h~l~~~~~~~~a 219 (312) +- +|++...|-..++.. ++..++..+..... T Consensus 157 ~e--~Sak~~~~I~~lf~~---i~~~i~~~~~~~~~ 187 (212) T 2j0v_A 157 IE--CSSKTQQNVKAVFDT---AIKVVLQPPRRKEV 187 (212) T ss_dssp EE--CCTTTCTTHHHHHHH---HHHHHHCC------ T ss_pred EE--EECCCCCCHHHHHHH---HHHHHHHHHHCCCC T ss_conf 98--850578688899999---99999741210123 No 93 >1kao RAP2A; GTP-binding protein, small G protein, GDP, RAS; HET: GDP; 1.7A {Homo sapiens} SCOP: c.37.1.8 Probab=97.03 E-value=0.49 Score=28.56 Aligned_columns=158 Identities=6% Q ss_pred EEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCCCCEEEE Q ss_conf 89975983317999998514778655665575025633562121332688998607854358878877187787827999 Q Fun_Sc_NP_0140 28 AIIYSPSSKTLHQFINICFPEGSNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHSSKVRWLI 107 (312) Q Consensus 28 ~lilg~~~~~~~~fi~~l~~~~~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s~~~l~Vi 107 (312) ++++|..+.|||+|++++-...........+.+.....+.-+ .....+..|-..|.-......-.++ ..-.-+++ T Consensus 6 i~liG~~~vGKTSll~~l~~~~~~~~~~~t~~~~~~~~~~~~-~~~~~~~~~d~~g~~~~~~~~~~~~----~~~~~~i~ 80 (167) T 1kao 6 VVVLGSGGVGKSALTVQFVTGTFIEKYDPTIEDFYRKEIEVD-SSPSVLEILDTAGTEQFASMRDLYI----KNGQGFIL 80 (167) T ss_dssp EEEECCTTSSHHHHHHHHHHSCCCSCCCTTCCEEEEEEEEET-TEEEEEEEEECCCTTCCHHHHHHHH----HHCSEEEE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEEEEECC-CEEEEEEEECCCCCCCHHHHHHHHH----HCCCEEEE T ss_conf 998807998789999998648236553442025776643048-8268887530567530135677775----20120133 Q ss_pred EECCCCCCHHHHHHHHHHHHHHHHCCCCC-CCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEC Q ss_conf 85166634468999999999986406899-87389984773456655324541157889999999999988294158852 Q Fun_Sc_NP_0140 108 LLDWTLNDQKLWLNELSYAFNKIKQLNDD-NEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSLFYIC 186 (312) Q Consensus 108 LLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~D-t~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGASLiYts 186 (312) ..|-+ |++.+-+.-.-+-...+....+ .+++||..|+|.-..-+-. .+-++.++-.+|+..+-+ T Consensus 81 v~d~~--~~~s~~~~~~~~~~~~~~~~~~~~piiiv~nK~Dl~~~~~v~------------~~~~~~~~~~~~~~~~~~- 145 (167) T 1kao 81 VYSLV--NQQSFQDIKPMRDQIIRVKRYEKVPVILVGNKVDLESEREVS------------SSEGRALAEEWGCPFMET- 145 (167) T ss_dssp EEETT--CHHHHHHHHHHHHHHHHHTTTSCCCEEEEEECGGGGGGCCSC------------HHHHHHHHHHHTSCEEEE- T ss_pred EECCC--CCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCC------------HHHHHHHHHHCCCCEEEE- T ss_conf 32243--101221112445677642034541134531122100001578------------889999999649808998- Q ss_pred CCCCHHHHHHHHHHHHHHHHHHCC Q ss_conf 565313555667788887530012 Q Fun_Sc_NP_0140 187 EDHTEEKREEAQRLKYQELLKHFC 210 (312) Q Consensus 187 ~ts~~~~kn~~~~l~y~~L~~h~l 210 (312) |++...+-..++.. ++..+ T Consensus 146 --Sa~~~~gi~elf~~---li~~i 164 (167) T 1kao 146 --SAKSKTMVDELFAE---IVRQM 164 (167) T ss_dssp --CTTCHHHHHHHHHH---HHHHH T ss_pred --ECCCCCCHHHHHHH---HHHHH T ss_conf --62688687899999---99984 No 94 >1zbd_A Rabphilin-3A; G protein, effector, RABCDR, synaptic exocytosis, RAB protein, RAB3A; HET: GTP; 2.60A {Rattus norvegicus} SCOP: c.37.1.8 Probab=97.01 E-value=0.35 Score=29.44 Aligned_columns=159 Identities=9% Q ss_pred EEEECCCCHHHHHHHHHHCC-CCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCCCCEEE Q ss_conf 89975983317999998514-77865566557502563356212133268899860785435887887718778782799 Q Fun_Sc_NP_0140 28 AIIYSPSSKTLHQFINICFP-EGSNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHSSKVRWL 106 (312) Q Consensus 28 ~lilg~~~~~~~~fi~~l~~-~~~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s~~~l~V 106 (312) ++++|....||++|+.++.. .-.+...+..+.++....+..+ .....+.+|-..|.-.... -.......-..++ T Consensus 11 i~ivG~~~vGKTsLi~~l~~~~~~~~~~~t~~~~~~~~~~~~~-~~~~~~~i~D~~g~~~~~~----~~~~~~~~~~~~i 85 (203) T 1zbd_A 11 ILIIGNSSVGKTSFLFRYADDSFTPAFVSTVGIDFKVKTIYRN-DKRIKLQIWDTAGLERYRT----ITTAYYRGAMGFI 85 (203) T ss_dssp EEEECSTTSSHHHHHHHHHTCCCCSCCCCCCSEEEEEEEEEET-TEEEEEEEEEECCSGGGHH----HHHTTGGGCSEEE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCC-CCCCCEEEECCCCCHHHHH----HHHHHCCCCCEEE T ss_conf 7788179987999999986482155412421233343102111-2256224631677526788----9987503773689 Q ss_pred EEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEC Q ss_conf 98516663446899999999998640689987389984773456655324541157889999999999988294158852 Q Fun_Sc_NP_0140 107 ILLDWTLNDQKLWLNELSYAFNKIKQLNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSLFYIC 186 (312) Q Consensus 107 iLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGASLiYts 186 (312) ++.|-+..+....++..+..+..+...+. +++||..|+| |..+.....++.-+|..+ +|...|-+ T Consensus 86 ~v~d~~~~~s~~~~~~~~~~~~~~~~~~~--piivvgnK~D----l~~~~~v~~~~~~~~~~~--------~~~~~~e~- 150 (203) T 1zbd_A 86 LMYDITNEESFNAVQDWSTQIKTYSWDNA--QVLLVGNKCD----MEDERVVSSERGRQLADH--------LGFEFFEA- 150 (203) T ss_dssp EEEETTCHHHHHHHHHHHHHHHHHSCSSC--EEEEEEECTT----CTTSCCSCHHHHHHHHHH--------HTCEEEEC- T ss_pred EEEECCCCCHHHHHHHHHHHHHHCCCCEE--EEEEECCCCH----HHHHHCCHHHHHHHHHHH--------CCCEEEEE- T ss_conf 99854772013455443333210114405--8986114420----222211026778899986--------29828999- Q ss_pred CCCCHHHHHHHHHHHHHHHHHHCCC Q ss_conf 5653135556677888875300124 Q Fun_Sc_NP_0140 187 EDHTEEKREEAQRLKYQELLKHFCE 211 (312) Q Consensus 187 ~ts~~~~kn~~~~l~y~~L~~h~l~ 211 (312) |++...|-...+.. ++..+. T Consensus 151 --Sa~~g~gi~~~f~~---l~~~i~ 170 (203) T 1zbd_A 151 --SAKDNINVKQTFER---LVDVIC 170 (203) T ss_dssp --BTTTTBSSHHHHHH---HHHHHH T ss_pred --ECCCCCCHHHHHHH---HHHHHH T ss_conf --61689788899999---999999 No 95 >d1kmqa_ c.37.1.8 (A:) RhoA {Human (Homo sapiens)} SCOP: d1cc0a_ d1ow3b_ d1xcgb_ d1ftn__ d1x86b_ d1s1ca_ d1lb1b_ d1tx4b_ d1cxza_ d1a2b__ u1z2ca1 d1dpfa_ u2fv8a1 Probab=96.99 E-value=0.095 Score=32.76 Aligned_columns=173 Identities=8% Q ss_pred CEEEEECCCCHHHHHHHHHHCC-CCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCCCCE Q ss_conf 4389975983317999998514-778655665575025633562121332688998607854358878877187787827 Q Fun_Sc_NP_0140 26 ITAIIYSPSSKTLHQFINICFP-EGSNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHSSKVR 104 (312) Q Consensus 26 k~~lilg~~~~~~~~fi~~l~~-~~~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s~~~l 104 (312) +-++++|+.+.||++|++++.. .-.+.+.+..+..|......++. ..++.+|-..+ ...+..+.+.++ +.-.. T Consensus 3 ~KI~iiG~~~vGKTsli~~~~~~~~~~~~~~t~~~~~~~~~~~~~~--~~~~~i~D~~g-~~~~~~~~~~~~---~~~~~ 76 (177) T d1kmqa_ 3 KKLVIVGDGACGKTCLLIVNSKDQFPEVYVPTVFENYVADIEVDGK--QVELALWDTAG-LEDYDRLRPLSY---PDTDV 76 (177) T ss_dssp EEEEEEESTTSSHHHHHHHHHHSCCCSSCCCCSEEEEEEEEEETTE--EEEEEEEEECC-SGGGTTTGGGGC---TTCSE T ss_pred EEEEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEECCC--EEEEEEEECCC-CCCCCCCHHHHC---CCCEE T ss_conf 5899982699879999999862743665233044336889876591--68888875155-100121100001---02203 Q ss_pred EEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEE Q ss_conf 99985166634468999999999986406899873899847734566553245411578899999999999882941588 Q Fun_Sc_NP_0140 105 WLILLDWTLNDQKLWLNELSYAFNKIKQLNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSLFY 184 (312) Q Consensus 105 ~ViLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGASLiY 184 (312) +++..|-+. ++.|......|...++....+.++++|+.|+|-.+.-+-+...-....=..-......++-+.|+-.++ T Consensus 77 ~ilv~d~~~--~~s~~~~~~~~~~~~~~~~~~~piiivgnK~Dl~~~~~~~~~~~~~~~~~v~~~~~~~~a~~~~~~~~~ 154 (177) T d1kmqa_ 77 ILMCFSIDS--PDSLENIPEKWTPEVKHFCPNVPIILVGNKKDLRNDEHTRRELAKMKQEPVKPEEGRDMANRIGAFGYM 154 (177) T ss_dssp EEEEEETTC--HHHHHHHHHTHHHHHHHHSTTSCEEEEEECGGGTTCHHHHHHHHHTTCCCCCHHHHHHHHHHTTCSEEE T ss_pred EEEEEECCC--HHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEE T ss_conf 567630460--678998876578999851565236887513465543025688887640278989999999972893389 Q ss_pred ECCCCCHHHHHHHHHHHHHHHHHH Q ss_conf 525653135556677888875300 Q Fun_Sc_NP_0140 185 ICEDHTEEKREEAQRLKYQELLKH 208 (312) Q Consensus 185 ts~ts~~~~kn~~~~l~y~~L~~h 208 (312) - +|+++..|....+....-.++ T Consensus 155 e--~Saktg~gi~e~fe~i~r~al 176 (177) T d1kmqa_ 155 E--CSAKTKDGVREVFEMATRAAL 176 (177) T ss_dssp E--CCTTTCTTHHHHHHHHHHHHH T ss_pred E--EEECCCCCHHHHHHHHHHHHC T ss_conf 9--750588788899999999970 No 96 >cd01869 Rab1_Ypt1 Rab1/Ypt1 subfamily. Rab1 is found in every eukaryote and is a key regulatory component for the transport of vesicles from the ER to the Golgi apparatus. Studies on mutations of Ypt1, the yeast homolog of Rab1, showed that this protein is necessary for the budding of vesicles of the ER as well as for their transport to, and fusion with, the Golgi apparatus. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site at the C-terminus, with sequence motifs CC, CXC, or CCX. Lipid binding is essential for membrane attachment, a key feature of most Rab proteins. Due to t Probab=96.97 E-value=0.21 Score=30.75 Aligned_columns=160 Identities=8% Q ss_pred EEEECCCCHHHHHHHHHHCC-CCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCCCCEEE Q ss_conf 89975983317999998514-77865566557502563356212133268899860785435887887718778782799 Q Fun_Sc_NP_0140 28 AIIYSPSSKTLHQFINICFP-EGSNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHSSKVRWL 106 (312) Q Consensus 28 ~lilg~~~~~~~~fi~~l~~-~~~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s~~~l~V 106 (312) ++++|+.+-|||.|+.+... .-.+.+.+..|.+|....+.-+ ....++.+|=..| .+.+..+.......- .-++ T Consensus 5 iv~vGd~~vGKTsli~r~~~~~f~~~y~~Tig~~~~~k~i~~~-~~~v~l~iwDt~G-~e~~~~l~~~~~~~a---~~~i 79 (166) T cd01869 5 LLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELD-GKTIKLQIWDTAG-QERFRTITSSYYRGA---HGII 79 (166) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEEC-CEEEEEEEEECCC-CHHHHHHHHHHCCCC---CEEE T ss_conf 9998269954899999875380066657601235678899998-9589999862688-601123112122689---8899 Q ss_pred EEECCCCCCHHHHHHHHHHHHHHH-HCCCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEE Q ss_conf 985166634468999999999986-4068998738998477345665532454115788999999999998829415885 Q Fun_Sc_NP_0140 107 ILLDWTLNDQKLWLNELSYAFNKI-KQLNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSLFYI 185 (312) Q Consensus 107 iLLDWs~~Dp~~Wlr~Lr~~~~~L-~~l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGASLiYt 185 (312) |.-|-+ ...=...+..|+..+ +...++.++++|-.|+|-...-+-+ .+-.+.++-.+|+..+-| T Consensus 80 ivfdit---~~~Sf~~i~~w~~~i~~~~~~~~~~ilVGNK~Dl~~~r~V~------------~~~~~~~a~~~~~~~~E~ 144 (166) T cd01869 80 IVYDVT---DQESFNNVKQWLQEIDRYASENVNKLLVGNKCDLTDKRVVD------------YSEAQEFADELGIPFLET 144 (166) T ss_pred EEEECC---CHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCC------------HHHHHHHHHHCCCCEEEE T ss_conf 998679---85689999999999987259982799985033333245579------------899999999659959999 Q ss_pred CCCCCHHHHHHHHHHHHHHHHHHCCCCC Q ss_conf 2565313555667788887530012477 Q Fun_Sc_NP_0140 186 CEDHTEEKREEAQRLKYQELLKHFCEDR 213 (312) Q Consensus 186 s~ts~~~~kn~~~~l~y~~L~~h~l~~~ 213 (312) |++...|-...+.. ++..+..+ T Consensus 145 ---Sak~g~~V~e~F~~---la~~i~~~ 166 (166) T cd01869 145 ---SAKNATNVEQAFMT---MAREIKKR 166 (166) T ss_pred ---ECCCCCCHHHHHHH---HHHHHHCC T ss_conf ---71489887899999---99999609 No 97 >cd01863 Rab18 Rab18 subfamily. Mammalian Rab18 is implicated in endocytic transport and is expressed most highly in polarized epithelial cells. However, trypanosomal Rab, TbRAB18, is upregulated in the BSF (Blood Stream Form) stage and localized predominantly to elements of the Golgi complex. In human and mouse cells, Rab18 has been identified in lipid droplets, organelles that store neutral lipids. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site at the C-terminus, with sequence motifs CC, CXC, or CCX. Lipid binding is essential for membrane attachment, a key feature of mos Probab=96.96 E-value=0.33 Score=29.55 Aligned_columns=156 Identities=10% Q ss_pred EEEECCCCHHHHHHHHHHCC-CCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCCCCEEE Q ss_conf 89975983317999998514-77865566557502563356212133268899860785435887887718778782799 Q Fun_Sc_NP_0140 28 AIIYSPSSKTLHQFINICFP-EGSNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHSSKVRWL 106 (312) Q Consensus 28 ~lilg~~~~~~~~fi~~l~~-~~~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s~~~l~V 106 (312) ++++|..+-|||+|+.+... .-.+.+.+..|.++.-..+.-+ ....++..|=..|. ..+..+.+.....-. .++ T Consensus 3 iv~iG~~~VGKTsli~r~~~~~f~~~~~~Ti~~~~~~k~i~~~-~~~~~l~iwDt~G~-e~~~~l~~~~~~~~~---~~i 77 (161) T cd01863 3 ILLIGDSGVGKSSLLLRFTDDTFDPDLAATIGVDFKVKTLTVD-GKKVKLAIWDTAGQ-ERFRTLTSSYYRGAQ---GVI 77 (161) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEEC-CEEEEEEEEECCCC-CHHHHHHHHHCCCCC---EEE T ss_conf 8998079965899999986282077656510002458899898-96999999754887-101245475435998---799 Q ss_pred EEECCCCCCHHHHHHHHHHHHHHHHC--CCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEE Q ss_conf 98516663446899999999998640--6899873899847734566553245411578899999999999882941588 Q Fun_Sc_NP_0140 107 ILLDWTLNDQKLWLNELSYAFNKIKQ--LNDDNEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSLFY 184 (312) Q Consensus 107 iLLDWs~~Dp~~Wlr~Lr~~~~~L~~--l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGASLiY 184 (312) +.-|-+ ..-=...+..|+..+++ ...+-++++|..|+| |+..... ..-.+.++..+|+..+. T Consensus 78 ~vfd~t---~~~Sf~~i~~w~~~i~~~~~~~~~~~ilvGNK~D----l~~r~v~---------~~e~~~~a~~~~~~~~e 141 (161) T cd01863 78 LVYDVT---RRDTFTNLETWLNELETYSTNNDIVKMLVGNKID----KENREVT---------REEGLKFARKHNMLFIE 141 (161) T ss_pred EEEECC---CHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCC----CCCCCCC---------HHHHHHHHHHCCCEEEE T ss_conf 998569---8679999999999999733899938999612334----3000488---------88999999966992999 Q ss_pred ECCCCCHHHHHHHHHHHHHHHHHHCC Q ss_conf 52565313555667788887530012 Q Fun_Sc_NP_0140 185 ICEDHTEEKREEAQRLKYQELLKHFC 210 (312) Q Consensus 185 ts~ts~~~~kn~~~~l~y~~L~~h~l 210 (312) + |++...|-..++.. ++..+ T Consensus 142 ~---SAk~~~nv~e~F~~---l~~~i 161 (161) T cd01863 142 T---SAKTRDGVQQAFEE---LVEKI 161 (161) T ss_pred E---ECCCCCCHHHHHHH---HHHHC T ss_conf 9---70589787899999---99849 No 98 >2il1_A RAB12; G-protein, GDP, GTPase, predicted, structural genomics, structural genomics consortium, SGC; HET: GDP; 2.10A {Homo sapiens} Probab=96.96 E-value=0.38 Score=29.19 Aligned_columns=176 Identities=7% Q ss_pred HCCCCCCCCCCCC--------EEEEECCCCHHHHHHHHHHCCCC-CCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECC Q ss_conf 1011465536644--------38997598331799999851477-86556655750256335621213326889986078 Q Fun_Sc_NP_0140 14 NESTINSTETATI--------TAIIYSPSSKTLHQFINICFPEG-SNSILDTTLINYATIGWTNDLKENYSVDVYTLIRN 84 (312) Q Consensus 14 ~~~~~~~k~~~~k--------~~lilg~~~~~~~~fi~~l~~~~-~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~ 84 (312) ++.++++-.|.+. .++++|..+.||++|++++.... .+.+..+...+.....+.-+ ..+..+.+|-..+. T Consensus 7 ~~~~~~~~~p~~~~~~~~~~~KI~liG~~~vGKSsLi~~l~~~~~~~~~~~t~~~~~~~~~i~~~-~~~~~~~i~D~~g~ 85 (192) T 2il1_A 7 HHHHSSGLVPRGSPRPADFKLQVIIIGSRGVGKTSLMERFTDDTFCEACKSTVGVDFKIKTVELR-GKKIRLQIWDTAGQ 85 (192) T ss_dssp ---------------CCSEEEEEEEECSTTSSHHHHHHHHCC--------CCTTEEEEEEEEEET-TEEEEEEEEEECCS T ss_pred CCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEEE-CCEEEEEEEECCCC T ss_conf 22322367888888861315789998269987899999986580145413430247889985200-11034677414564 Q ss_pred CHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCCCHHHH Q ss_conf 54358878877187787827999851666344689999999999864068998738998477345665532454115788 Q Fun_Sc_NP_0140 85 TDDALDLLKPFLQEHSSKVRWLILLDWTLNDQKLWLNELSYAFNKIKQLNDDNEFSVWCLNSGEILNLQRHTTVWQSVHI 164 (312) Q Consensus 85 ~~~~~~LLkp~L~~~s~~~l~ViLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~Dt~i~VVc~~sD~i~~LEKe~~~w~de~f 164 (312) .....-.......++. ++++.|-+. +..+-..-..+-...+.....-++++|..|+| |+++.-...++.. T Consensus 86 ~~~~~~~~~~~~~~~~----~i~v~d~~~--~~s~~~~~~~~~~~~~~~~~~~piiiv~nK~D----l~~~~~v~~~~~~ 155 (192) T 2il1_A 86 ERFNSITSAYYRSAKG----IILVYDITK--KETFDDLPKWMKMIDKYASEDAELLLVGNKLD----CETDREITRQQGE 155 (192) T ss_dssp GGGHHHHHHHHHHCSE----EEEEEETTC--HHHHHTHHHHHHHHHHHSCTTCEEEEEEECGG----GGGGCCSCHHHHH T ss_pred CCCCCCCCCCCCCCEE----EEEEECCCC--CHHHHHHHHHHHHHHHHCCCCCHHHHHEHHCC----CHHHCCCHHHHHH T ss_conf 3112001000324116----888612533--10121012345555431124410220010012----0110230079999 Q ss_pred HHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCC Q ss_conf 9999999999988294158852565313555667788887530012477 Q Fun_Sc_NP_0140 165 DFILQTLRSFCYFNDSSLFYICEDHTEEKREEAQRLKYQELLKHFCEDR 213 (312) Q Consensus 165 DfIqQ~LRtvcL~yGASLiYts~ts~~~~kn~~~~l~y~~L~~h~l~~~ 213 (312) +|.+ ++++-.++- +|+++..+-..++.. ++..+..+ T Consensus 156 ~~~~--------~~~~~~~~e--~Sa~~~~gi~elf~~---l~~~ilk~ 191 (192) T 2il1_A 156 KFAQ--------QITGMRFCE--ASAKDNFNVDEIFLK---LVDDILKK 191 (192) T ss_dssp HHHH--------TSTTCEEEE--CBTTTTBSHHHHHHH---HHHHHHHT T ss_pred HHHH--------HHCCCEEEE--EECCCCCCHHHHHHH---HHHHHHHH T ss_conf 9999--------807973899--851588788899999---99999982 No 99 >cd04117 Rab15 Rab15 subfamily. Rab15 colocalizes with the transferrin receptor in early endosome compartments, but not with late endosomal markers. It codistributes with Rab4 and Rab5 on early/sorting endosomes, and with Rab11 on pericentriolar recycling endosomes. It is believed to function as an inhibitory GTPase that regulates distinct steps in early endocytic trafficking. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site at the C-terminus, with sequence motifs CC, CXC, or CCX. Lipid binding is essential for membrane attachment, a key feature of most Rab proteins. Due to Probab=96.96 E-value=0.63 Score=27.89 Aligned_columns=157 Identities=5% Q ss_pred EEEECCCCHHHHHHHHHHCC-CCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCCCCCEEE Q ss_conf 89975983317999998514-77865566557502563356212133268899860785435887887718778782799 Q Fun_Sc_NP_0140 28 AIIYSPSSKTLHQFINICFP-EGSNSILDTTLINYATIGWTNDLKENYSVDVYTLIRNTDDALDLLKPFLQEHSSKVRWL 106 (312) Q Consensus 28 ~lilg~~~~~~~~fi~~l~~-~~~e~~~~~~~L~y~y~~v~~d~~d~~R~~vy~L~~~~~~~~~LLkp~L~~~s~~~l~V 106 (312) ++++|+.+-|||.|+.+... .=.+.+....|.+|....+.- ++.++.+.+.+.+..+.-..+.+..-..+. -++ T Consensus 3 IiliGd~~VGKTsli~rf~~~~F~~~~~~Tig~~~~~k~i~~---~~~~i~l~iwDtaG~e~~~~l~~~~~~~a~--~~i 77 (161) T cd04117 3 LLLIGDSGVGKTCLLCRFTDNEFHSSHISTIGVDFKMKTIEV---DGIKVRIQIWDTAGQERYQTITKQYYRRAQ--GIF 77 (161) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEE---CCEEEEEEEEECCCCHHHHHHHHHHCCCCC--EEE T ss_conf 899826984489999987548217543442211146789989---896999998746987235667686446998--899 Q ss_pred EEECCCCCCHHHHHHHHHHHHHHHHCCCCC-CCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEE Q ss_conf 985166634468999999999986406899-8738998477345665532454115788999999999998829415885 Q Fun_Sc_NP_0140 107 ILLDWTLNDQKLWLNELSYAFNKIKQLNDD-NEFSVWCLNSGEILNLQRHTTVWQSVHIDFILQTLRSFCYFNDSSLFYI 185 (312) Q Consensus 107 iLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~D-t~i~VVc~~sD~i~~LEKe~~~w~de~fDfIqQ~LRtvcL~yGASLiYt 185 (312) +.-|-+. +...-+... |+..+++..++ .++++|..|+| |++.+ ..-..-.+.++-.+|+..|.| T Consensus 78 lvydit~--~~Sf~~i~~-w~~~i~~~~~~~~~~ilVgnK~D----l~~~r--------~v~~~e~~~~a~~~~~~~~E~ 142 (161) T cd04117 78 LVYDISS--ERSYQHIMK-WVSDVDEYAPEGVQKILIGNKAD----EEQKR--------QVGDEQGNKLAKEYGMDFFET 142 (161) T ss_pred EEEECCC--HHHHHHHHH-HHHHHHHHCCCCCEEEEEECCCC----HHHHH--------HHHHHHHHHHHHHCCCCEEEE T ss_conf 9986599--789999999-99999972579946999811578----02311--------146899999999659969999 Q ss_pred CCCCCHHHHHHHHHHHHHHHHH Q ss_conf 2565313555667788887530 Q Fun_Sc_NP_0140 186 CEDHTEEKREEAQRLKYQELLK 207 (312) Q Consensus 186 s~ts~~~~kn~~~~l~y~~L~~ 207 (312) |+++..|-...+...+=++ T Consensus 143 ---SAk~~~nV~e~F~~la~li 161 (161) T cd04117 143 ---SACTNSNIKESFTRLTELV 161 (161) T ss_pred ---ECCCCCCHHHHHHHHHHHC T ss_conf ---7158988789999999829 No 100 >2f7s_A C25KG, RAS-related protein RAB-27B; G-protein, structural genomics, structural genomics consortium, SGC; HET: GDP; 2.70A {Homo sapiens} SCOP: c.37.1.8 Probab=96.95 E-value=0.25 Score=30.28 Aligned_columns=166 Identities=8% Q ss_pred CCCCCCCCCC-------EEEEECCCCHHHHHHHHHHCC-CCCCCCCCCCCCEEEEECCCCCCCCCE-------EEEEEEE Q ss_conf 1465536644-------389975983317999998514-778655665575025633562121332-------6889986 Q Fun_Sc_NP_0140 17 TINSTETATI-------TAIIYSPSSKTLHQFINICFP-EGSNSILDTTLINYATIGWTNDLKENY-------SVDVYTL 81 (312) Q Consensus 17 ~~~~k~~~~k-------~~lilg~~~~~~~~fi~~l~~-~~~e~~~~~~~L~y~y~~v~~d~~d~~-------R~~vy~L 81 (312) +++|-.|++- .++|+|+...||++|++++.. .-.+.+.+..+..|....+..+..... .+.+.+. T Consensus 10 ~~~~~~~~~~~~~~~~~KI~ivG~~~vGKSSLi~~l~~~~~~~~~~~t~~~~~~~~~i~~~~~~~~~~~~~~~~~~l~i~ 89 (217) T 2f7s_A 10 HSSGLVPRGSGDYDYLIKLLALGDSGVGKTTFLYRYTDNKFNPKFITTVGIDFREKRVVYNAQGPNGSSGKAFKVHLQLW 89 (217) T ss_dssp -----------CCSEEEEEEEESCTTSSHHHHHHHHHCSCCCCEEEEEEEEEEEEEEEEEEC-------CCEEEEEEEEE T ss_pred CCCCCCCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEECCCCCCCCCCCCEEEEEEEE T ss_conf 34577889999854699999981699779999999864800775234102467899997568642122345317999987 Q ss_pred ECCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCE--EEEEECCCHHHHHHHCCCCC Q ss_conf 0785435887887718778782799985166634468999999999986406899873--89984773456655324541 Q Fun_Sc_NP_0140 82 IRNTDDALDLLKPFLQEHSSKVRWLILLDWTLNDQKLWLNELSYAFNKIKQLNDDNEF--SVWCLNSGEILNLQRHTTVW 159 (312) Q Consensus 82 ~~~~~~~~~LLkp~L~~~s~~~l~ViLLDWs~~Dp~~Wlr~Lr~~~~~L~~l~~Dt~i--~VVc~~sD~i~~LEKe~~~w 159 (312) +.+.......+.+..-.+.. .++++.|-+. +..+ ..+..|+..++......++ ++|+.|+|-....+-.. T Consensus 90 D~~g~e~~~~~~~~~~~~~d--~~i~v~d~~~--~~s~-~~~~~~~~~i~~~~~~~~~~iilv~nK~Dl~~~~~i~~--- 161 (217) T 2f7s_A 90 DTAGQERFRSLTTAFFRDAM--GFLLMFDLTS--QQSF-LNVRNWMSQLQANAYCENPDIVLIGNKADLPDQREVNE--- 161 (217) T ss_dssp EEESHHHHHHHHHHHHTTCC--EEEEEEETTC--HHHH-HHHHHHHHTCCCCCTTTCCEEEEEEECTTCGGGCCSCH--- T ss_pred EECCCCHHHHHHHHHHHCCC--EEEEEEECCC--CCCC-CCCCCCHHHHHHHHCCCCCEEEEEEECCCHHHHHCCCH--- T ss_conf 50372011023133201006--3489961665--5553-20021102334330246622688750234113203357--- Q ss_pred CHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHH Q ss_conf 1578899999999999882941588525653135556677888 Q Fun_Sc_NP_0140 160 QSVHIDFILQTLRSFCYFNDSSLFYICEDHTEEKREEAQRLKY 202 (312) Q Consensus 160 ~de~fDfIqQ~LRtvcL~yGASLiYts~ts~~~~kn~~~~l~y 202 (312) +-++.++-.+++.++-+ |+++..|-..++.. T Consensus 162 ---------~~~~~~~~~~~~~~~e~---Sak~g~~I~e~f~~ 192 (217) T 2f7s_A 162 ---------RQARELADKYGIPYFET---SAATGQNVEKAVET 192 (217) T ss_dssp ---------HHHHHHHHHTTCCEEEE---BTTTTBTHHHHHHH T ss_pred ---------HHHHHHHHHCCCCEEEE---ECCCCCCHHHHHHH T ss_conf ---------89999999659928999---61578688999999 Done!