Query Ver_Hs_NP_057092.2_Lic3 Command /cluster/toolkit/production/bioprogs/hhpred/hhsearch -cal -cpu 4 -v 1 -i /cluster/toolkit/production/tmp/production/96176/Hs_NP_057092.hhm -d /cluster/toolkit/production/databases/hhpred/new_dbs/pdb70_3Jan08/db/pdb.hhm /cluster/toolkit/production/databases/hhpred/new_dbs/scop70_1.72pre/db/scop.hhm /cluster/toolkit/production/databases/hhpred/new_dbs/scop70_1.71/db/scop.hhm /cluster/toolkit/production/databases/hhpred/new_dbs/pfamA_22.0/db/pfamA.hhm /cluster/toolkit/production/databases/hhpred/new_dbs/smart_18Apr07/db/smart.hhm /cluster/toolkit/production/databases/hhpred/new_dbs/pfam_18Apr07/db//pfam.hhm /cluster/toolkit/production/databases/hhpred/new_dbs/KOG_18Apr07/db/KOG.hhm /cluster/toolkit/production/databases/hhpred/new_dbs/COG_18Apr07/db/COG.hhm /cluster/toolkit/production/databases/hhpred/new_dbs/cd_18Apr07/db/cd.hhm /cluster/toolkit/production/databases/hhpred/new_dbs/panther_13Dec06/db/panther.hmm /cluster/toolkit/production/databases/hhpred/new_dbs/tigrfam_13Dec06/db/tigrfam.hmm /cluster/toolkit/production/databases/hhpred/new_dbs/pirsf_13Dec06/db/pirsf.hmm /cluster/toolkit/production/databases/hhpred/new_dbs/supfam_13Dec06/db/supfam.hmm /cluster/toolkit/production/databases/hhpred/new_dbs/CATH_13Dec06/db/CATH.hmm -o /cluster/toolkit/production/tmp/production/96176/Hs_NP_057092.hhr -p 20 -P 20 -Z 100 -B 100 -seq 1 -aliw 80 -local -ssm 2 -norealign -sc 1 No Hit Prob E-value P-value Score SS Cols Query HMM Template HMM 1 KOG3929 Uncharacterized conser 100.0 0 0 796.2 18.2 345 1-351 10-363 (363) 2 PTHR13236 DYNEIN 2 LIGHT INTER 100.0 0 0 694.1 22.4 345 1-345 10-382 (397) 3 KOG3905 Dynein light intermedi 100.0 0 0 314.8 19.2 254 4-269 31-320 (473) 4 PF05783 DLIC: Dynein light in 100.0 6.6E-44 0 301.7 21.1 255 4-269 26-333 (525) 5 pfam05783 DLIC Dynein light in 100.0 1.2E-43 0 300.0 18.2 254 4-269 26-315 (475) 6 PTHR12688 DYNEIN LIGHT INTERME 100.0 2.7E-31 2.8E-36 221.6 7.6 201 63-268 1-231 (415) 7 cd04128 Spg1 Spg1p. Spg1p (se 99.6 7.4E-14 7.8E-19 110.9 12.6 177 34-255 3-182 (182) 8 cd01860 Rab5_related Rab5-rela 99.5 9.2E-13 9.6E-18 103.9 9.8 153 34-238 4-159 (163) 9 cd04106 Rab23_lke Rab23-like s 99.5 1.7E-12 1.8E-17 102.2 10.9 155 34-238 3-159 (162) 10 cd00154 Rab Rab family. Rab G 99.5 1.6E-12 1.7E-17 102.4 10.5 154 34-238 3-158 (159) 11 cd01867 Rab8_Rab10_Rab13_like 99.5 1.5E-12 1.5E-17 102.6 10.3 154 34-238 6-161 (167) 12 cd04110 Rab35 Rab35 subfamily. 99.5 2.2E-12 2.3E-17 101.5 11.2 153 34-238 9-163 (199) 13 cd00876 Ras Ras family. The R 99.5 1.7E-12 1.7E-17 102.3 10.4 154 34-238 2-157 (160) 14 cd04109 Rab28 Rab28 subfamily. 99.4 5E-12 5.2E-17 99.3 11.8 158 34-238 3-162 (215) 15 cd01865 Rab3 Rab3 subfamily. 99.4 5.6E-12 5.9E-17 99.0 11.9 154 34-238 4-159 (165) 16 cd01869 Rab1_Ypt1 Rab1/Ypt1 su 99.4 2.9E-12 3E-17 100.8 10.4 154 34-238 5-160 (166) 17 cd04107 Rab32_Rab38 Rab38/Rab3 99.4 7.9E-12 8.2E-17 98.0 12.4 181 34-258 3-188 (201) 18 cd01866 Rab2 Rab2 subfamily. 99.4 6.6E-12 6.9E-17 98.5 11.8 154 34-238 7-162 (168) 19 cd04119 RJL RJL (RabJ-Like) su 99.4 4.7E-12 4.9E-17 99.5 10.9 159 34-238 3-163 (168) 20 cd01868 Rab11_like Rab11-like. 99.4 5.5E-12 5.8E-17 99.0 11.1 154 34-238 6-161 (165) 21 cd04120 Rab12 Rab12 subfamily. 99.4 8.4E-12 8.8E-17 97.8 11.9 172 34-254 3-184 (202) 22 cd04114 Rab30 Rab30 subfamily. 99.4 5.7E-12 6E-17 98.9 10.8 154 34-238 10-165 (169) 23 cd04122 Rab14 Rab14 subfamily. 99.4 6.9E-12 7.2E-17 98.4 11.2 153 34-238 5-160 (166) 24 cd04124 RabL2 RabL2 subfamily. 99.4 1.2E-11 1.3E-16 96.8 12.4 152 34-238 3-158 (161) 25 cd04112 Rab26 Rab26 subfamily. 99.4 5.1E-12 5.3E-17 99.2 10.4 154 34-238 3-159 (191) 26 e1z2aa_ c.37.1.8 (A:) Rab23 {M 99.4 2.3E-12 2.4E-17 101.4 8.6 153 34-238 5-159 (164) 27 1xtq_A GTP-binding protein RHE 99.4 1.5E-11 1.6E-16 96.3 12.5 154 34-238 9-164 (177) 28 cd04125 RabA_like RabA-like su 99.4 6.1E-12 6.4E-17 98.7 10.4 154 34-238 3-158 (188) 29 cd01861 Rab6 Rab6 subfamily. 99.4 5E-12 5.2E-17 99.3 9.9 154 34-238 3-158 (161) 30 cd04117 Rab15 Rab15 subfamily. 99.4 1.4E-11 1.5E-16 96.4 12.1 154 34-238 3-158 (161) 31 pfam00071 Ras Ras family. Incl 99.4 7.2E-12 7.5E-17 98.3 10.5 154 34-238 2-157 (162) 32 e1xtqa1 c.37.1.8 (A:3-169) GTP 99.4 1E-11 1.1E-16 97.3 11.2 161 28-237 1-165 (167) 33 cd04118 Rab24 Rab24 subfamily. 99.4 3.9E-12 4.1E-17 100.0 9.0 157 34-238 3-162 (193) 34 cd01864 Rab19 Rab19 subfamily. 99.4 7.7E-12 8E-17 98.1 10.5 154 34-238 6-162 (165) 35 1vg8_A RAS-related protein RAB 99.4 2.9E-11 3E-16 94.4 13.3 158 34-238 11-170 (207) 36 cd04175 Rap1 Rap1 subgroup. T 99.4 1.7E-11 1.8E-16 95.9 12.0 154 34-238 4-159 (164) 37 cd00157 Rho Rho (Ras homology) 99.4 8.9E-12 9.3E-17 97.7 9.9 158 34-238 3-169 (171) 38 d1wmsa_ c.37.1.8 (A:) Rab9a {H 99.4 2.4E-11 2.5E-16 94.9 12.1 157 34-238 9-168 (174) 39 2atx_A Small GTP binding prote 99.4 5.4E-12 5.6E-17 99.1 8.6 158 34-238 21-188 (194) 40 smart00174 RHO Rho (Ras homolo 99.4 5.2E-12 5.4E-17 99.2 8.5 158 34-238 1-168 (174) 41 e2erxa1 c.37.1.8 (A:6-176) di- 99.4 1.6E-11 1.7E-16 96.0 11.0 155 34-238 5-161 (171) 42 2hxs_A RAB-26, RAS-related pro 99.4 1.4E-11 1.5E-16 96.4 10.5 167 34-245 9-178 (178) 43 e1z0ja1 c.37.1.8 (A:2-168) Rab 99.4 3.6E-11 3.8E-16 93.8 12.3 154 34-238 7-162 (167) 44 cd04132 Rho4_like Rho4-like su 99.4 1E-11 1.1E-16 97.3 9.3 160 32-238 1-163 (187) 45 cd04116 Rab9 Rab9 subfamily. 99.4 5.3E-11 5.6E-16 92.7 13.0 157 34-238 8-167 (170) 46 e1z06a1 c.37.1.8 (A:32-196) Ra 99.4 2E-11 2.1E-16 95.4 10.8 158 34-238 5-165 (165) 47 cd04108 Rab36_Rab34 Rab34/Rab3 99.4 2.7E-11 2.8E-16 94.7 11.4 157 34-238 3-161 (170) 48 cd01862 Rab7 Rab7 subfamily. 99.4 3.2E-11 3.3E-16 94.2 11.6 160 34-238 3-167 (172) 49 cd01863 Rab18 Rab18 subfamily. 99.4 3.4E-11 3.5E-16 94.0 11.6 154 34-238 3-158 (161) 50 cd04176 Rap2 Rap2 subgroup. T 99.4 3.3E-11 3.5E-16 94.1 11.2 154 34-238 4-159 (163) 51 d3raba_ c.37.1.8 (A:) Rab3a {R 99.4 1.3E-11 1.3E-16 96.7 9.1 154 34-238 8-163 (169) 52 e2gjsa1 c.37.1.8 (A:91-258) Ra 99.4 2.5E-11 2.6E-16 94.8 10.4 155 34-238 4-158 (168) 53 cd04113 Rab4 Rab4 subfamily. 99.4 3E-11 3.2E-16 94.3 10.8 154 34-238 3-158 (161) 54 d1vg8a_ c.37.1.8 (A:) Rab7 {Ra 99.3 9.5E-12 1E-16 97.5 8.1 177 34-255 5-184 (184) 55 smart00175 RAB Rab subfamily o 99.3 2.6E-11 2.7E-16 94.8 10.0 154 34-238 3-158 (164) 56 1x3s_A RAS-related protein RAB 99.3 2.5E-11 2.6E-16 94.8 10.0 172 34-254 18-192 (195) 57 cd04141 Rit_Rin_Ric Rit/Rin/Ri 99.3 4.3E-11 4.5E-16 93.3 11.1 154 34-238 5-160 (172) 58 cd04136 Rap_like Rap-like subf 99.3 4.6E-11 4.8E-16 93.2 10.7 154 34-238 4-159 (163) 59 cd04123 Rab21 Rab21 subfamily. 99.3 5.9E-11 6.1E-16 92.5 11.0 154 34-238 3-158 (162) 60 2q3h_A RAS homolog gene family 99.3 3.3E-11 3.5E-16 94.0 9.7 172 20-238 4-190 (201) 61 cd04140 ARHI_like ARHI subfami 99.3 8E-11 8.4E-16 91.6 11.6 157 34-237 4-164 (165) 62 cd04152 Arl4_Arl7 Arl4/Arl7 su 99.3 2E-10 2.1E-15 89.1 13.6 160 33-238 5-166 (183) 63 cd04137 RheB Rheb (Ras Homolog 99.3 7E-11 7.3E-16 92.0 11.2 156 32-238 2-159 (180) 64 cd04139 RalA_RalB RalA/RalB su 99.3 7.5E-11 7.9E-16 91.8 11.3 154 34-238 3-158 (164) 65 e2a5ja1 c.37.1.8 (A:9-181) Rab 99.3 1.1E-10 1.1E-15 90.8 12.1 154 34-238 6-161 (173) 66 cd04101 RabL4 RabL4 (Rab-like4 99.3 4.2E-11 4.4E-16 93.4 9.9 154 34-238 3-160 (164) 67 2dpx_A GTP-binding protein RAD 99.3 3.6E-11 3.7E-16 93.8 9.5 155 34-238 10-164 (174) 68 d2ngra_ c.37.1.8 (A:) CDC42 {H 99.3 6.3E-11 6.6E-16 92.3 10.7 168 34-246 6-185 (191) 69 e2atxa1 c.37.1.8 (A:9-193) Rho 99.3 4.8E-11 5.1E-16 93.0 10.1 158 34-238 12-179 (185) 70 2fg5_A RAB-22B, RAS-related pr 99.3 4.9E-11 5.2E-16 93.0 10.0 154 34-238 26-181 (192) 71 2j0v_A RAC-like GTP-binding pr 99.3 2.7E-11 2.8E-16 94.6 8.6 158 34-238 12-175 (212) 72 cd04133 Rop_like Rop subfamily 99.3 3.4E-11 3.5E-16 94.0 9.1 158 34-238 4-169 (176) 73 cd01870 RhoA_like RhoA-like su 99.3 3.5E-11 3.7E-16 93.9 9.2 158 34-238 4-171 (175) 74 cd04135 Tc10 TC10 subfamily. 99.3 3.6E-11 3.7E-16 93.9 9.1 157 34-237 3-169 (174) 75 cd04121 Rab40 Rab40 subfamily. 99.3 5.3E-11 5.6E-16 92.7 10.0 153 34-238 9-163 (235) 76 d1m7ba_ c.37.1.8 (A:) RhoE (RN 99.3 5.2E-11 5.5E-16 92.8 9.9 158 34-238 5-173 (179) 77 1z2a_A RAS-related protein RAB 99.3 2.4E-11 2.5E-16 94.9 8.0 153 34-238 8-162 (168) 78 1ek0_A GTP-binding protein YPT 99.3 6.2E-11 6.5E-16 92.3 10.1 157 34-238 6-164 (170) 79 PF00071 Ras: Ras family; Int 99.3 8.6E-11 9E-16 91.4 10.8 158 34-238 2-169 (174) 80 cd04131 Rnd Rnd subfamily. Th 99.3 3.3E-11 3.5E-16 94.0 8.5 143 34-221 4-156 (178) 81 d1ky3a_ c.37.1.8 (A:) Rab-rela 99.3 1.4E-10 1.4E-15 90.2 11.3 160 34-238 5-167 (175) 82 cd04143 Rhes_like Rhes_like su 99.3 4.5E-10 4.7E-15 86.8 13.8 182 34-255 3-192 (247) 83 e1z0fa_ c.37.1.8 (A:) Rab14 {H 99.3 2E-10 2E-15 89.2 11.9 154 34-238 8-163 (167) 84 cd00877 Ran Ran (Ras-related n 99.3 1.4E-10 1.4E-15 90.1 11.0 151 34-238 3-155 (166) 85 2rex_B RHO-related GTP-binding 99.3 3.1E-11 3.3E-16 94.2 7.6 166 34-244 13-190 (197) 86 cd04129 Rho2 Rho2 subfamily. 99.3 9.5E-11 9.9E-16 91.1 10.1 160 34-238 4-173 (187) 87 e1x3sa1 c.37.1.8 (A:2-178) Rab 99.3 6.7E-11 7E-16 92.1 9.2 154 34-238 10-165 (177) 88 cd04111 Rab39 Rab39 subfamily. 99.3 2.3E-10 2.4E-15 88.7 12.0 156 34-238 5-162 (211) 89 cd04102 RabL3 RabL3 (Rab-like3 99.3 3.2E-11 3.3E-16 94.2 7.5 158 34-215 3-165 (202) 90 cd04127 Rab27A Rab27a subfamil 99.3 1.7E-10 1.8E-15 89.5 11.2 157 34-238 7-173 (180) 91 2f9l_A RAB11B, member RAS onco 99.3 6.2E-11 6.5E-16 92.3 8.8 154 34-238 8-163 (199) 92 d1g16a_ c.37.1.8 (A:) Rab-rela 99.3 2.8E-10 3E-15 88.1 12.1 155 34-238 5-159 (166) 93 1i2m_A RAN, GTP-binding nuclea 99.3 2.5E-11 2.6E-16 94.8 6.7 151 34-238 13-165 (216) 94 cd01892 Miro2 Miro2 subfamily. 99.3 9E-11 9.4E-16 91.3 9.5 152 34-238 7-162 (169) 95 1r2q_A RAS-related protein RAB 99.3 2.3E-10 2.4E-15 88.7 11.5 162 26-238 1-164 (170) 96 e2g6ba1 c.37.1.8 (A:58-227) Ra 99.3 1E-10 1E-15 91.0 9.7 154 34-238 9-165 (170) 97 d1c1ya_ c.37.1.8 (A:) Rap1A {H 99.3 1.3E-10 1.3E-15 90.4 10.2 154 34-238 6-162 (167) 98 d1r2qa_ c.37.1.8 (A:) Rab5a {H 99.3 1.1E-10 1.1E-15 90.9 9.7 162 26-238 1-164 (170) 99 2p5s_A RAS and EF-hand domain 99.3 2.4E-11 2.5E-16 94.9 6.3 161 34-238 31-192 (199) 100 smart00173 RAS Ras subfamily o 99.3 1.9E-10 2E-15 89.2 10.9 154 34-238 5-160 (166) No 1 >KOG3929 Uncharacterized conserved protein [Function unknown] Probab=100.00 E-value=0 Score=796.16 Aligned_columns=345 Identities=88% Q ss_pred CCCCCHHHHHHHHHHHCCCCCCCCCHHHC-----CCCEEEEEECCCCCHHHHHHHHCCCCCCC-CCCCCCCHHHHHHHCC Q ss_conf 98741889999876522576661101112-----57458998659886377777552766788-8753100022111015 Q Ver_Hs_NP_0570 1 MPSETLWEIAKAEVEKRGINGSEGDGAEI-----AEKFVFFIGSKNGGKTTIILRCLDRDEPP-KPTLALEYTYGRRAKG 74 (351) Q Consensus 1 ~~~~~lw~~~~~ev~~~~~~~~~~~~~~~-----~ek~v~~vGsk~~GKTTli~Rfl~r~e~~-KPTlALeYtygRra~~ 74 (351) ||-+++|.++.++++.+..++++++---. -|.|++|.|+++- ||+|++|++|++.+ .||+|||||||||++| T Consensus 10 m~Ve~~~~~a~a~~~~~DinG~~~deqL~e~~~~~E~~I~~~Gn~~~--tt~I~~~FdR~e~~~~ptlaLEYtygRR~~g 87 (363) T KOG3929 10 MPVETLWEIAKAEVEKRDINGSEGDEQLAEIAEKFEFFIGSKGNGGK--TTIILRCFDRDEPPKPPTLALEYTYGRRAKG 87 (363) T ss_pred HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHCEEEEECCCCE--EEEEEECCCCCCCCCCCCEEEEEHHHHHHCC T ss_conf 55555433454101244312321378999850300205677338850--6653300576567899721221012344147 Q ss_pred CCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH Q ss_conf 78711178889715785420211000042351206778887369846899999999999999999999998526953789 Q Ver_Hs_NP_0570 75 HNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSLVLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVS 154 (351) Q Consensus 75 ~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~viivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~ 154 (351) |+ +||||||||||||+++.+|++||||.+||++|++|+|||||+|+++|+|||+.++++|++|++++++|.+..+++.+ T Consensus 88 ~~-~kdiaN~WELGgg~~~~~LLsVPit~~~l~~~slIL~LDls~p~~~W~t~E~~~~~~R~~vd~~~~~~~k~~~~L~E 166 (363) T KOG3929 88 HN-PKDIANFWELGGGTSLLDLLSVPITGDTLRTFSLILVLDLSKPNDLWPTMENLLQATRSHVDKVIMKLGKTNAKLVE 166 (363) T ss_pred CC-CHHHHHHHHCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH T ss_conf 88-51456555326732468886055455628775666765115624432579999999998999999987414889999 Q ss_pred HHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCCCCCCHHHHHHHHHHHHHHHHHCCCEE-EEEECHHHHHHHHHHH Q ss_conf 999999984146677600111068877997121000158876678999999999998609468-8851203456789998 Q Ver_Hs_NP_0570 155 EMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVFQDFESEKRKVICKTLRFVAHYYGASL-MFTSKSEALLLKIRGV 233 (351) Q Consensus 155 ~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F~~~D~e~rK~i~r~LR~iAH~yGA~L-~FtSk~e~l~~r~r~~ 233 (351) +|+||.|+|+|+||+|.++++|||||++|||+|||+||+||||+|||+||||||+||+|||+| ||+|++++++..+|++ T Consensus 167 ~mrqR~~~rvgqd~~d~e~~dP~P~PV~IVgsKYDvFq~FesekRkH~C~~LRf~Ah~yGaaLlmfSskMe~l~K~ir~~ 246 (363) T KOG3929 167 EMRQRIWNRVGQDHPDHELIDPFPVPVVIVGSKYDVFQDFESEKRKHICKTLRFVAHYYGAALLMFSSKMEALLKKIRGV 246 (363) T ss_pred HHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_conf 99999998621468740002778853478535200012663678999999999999997789999888789999998777 Q ss_pred HHHHHCCCCCCCEEEEECCCCEEEECCCCCHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHH--CC Q ss_conf 8875057777730575067757870587636566887556531022245423678999998637897531234532--66 Q Ver_Hs_NP_0570 234 INQLAFGIDKSKSICVDQNKPLFITAGLDSFGQIGSPPVPENDIGKLHAHSPMELWKKVYEKLFPPKSINTLKDIK--DP 311 (351) Q Consensus 234 inhl~FG~~~~k~~~~D~~kPl~I~aG~DS~~~IG~P~~~~~~~g~~~~~~~ldlwk~~~~~~fP~k~~~~~k~~~--DP 311 (351) ||||+||++++++++||||+|+||+||+|||++||.||+++|++| |++|+++|+++|.+.||+++.+.+++.+ || T Consensus 247 i~HlaFG~~~~~s~~vD~NkPlfi~~G~DS~~~IG~pp~~~nd~G---a~sp~elw~~~F~~l~PQk~~~~~kd~kttDP 323 (363) T KOG3929 247 INHLAFGIDKSKSICVDQNKPLFITAGLDSFGQIGSPPVPENDIG---AHSPMELWKKVFEKLFPQKSINTLKDIKTTDP 323 (363) T ss_pred HHHHHCCCCCCCCEEEECCCCEEEEECCCCHHHCCCCCCCCCCCC---CCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCC T ss_conf 775404765766545307874589855532233378888743345---43337899999986334123455555430153 Q ss_pred CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC Q ss_conf 7788888358899999999999999876765654102469 Q Ver_Hs_NP_0570 312 ARDPQYAENEVDEMRIQKDLELEQYKRSSSKSWKQIELDS 351 (351) Q Consensus 312 ~~dp~f~E~~ID~lR~qKd~ELeqy~r~~~~~~~~~~~~~ 351 (351) ++||+|+|++||+||.||++||+||+|+..++||+-++++ T Consensus 324 a~DP~FKE~~IDe~r~qK~~EL~~~~Rs~~~R~k~E~~~~ 363 (363) T KOG3929 324 ARDPQFKENEIDEMRIQKDLELEQYKRSSSKRWKQEELDS 363 (363) T ss_pred CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC T ss_conf 3266655520678998888999888765766666665219 No 2 >PTHR13236 DYNEIN 2 LIGHT INTERMEDIATE CHAIN, ISOFORM 2. Probab=100.00 E-value=0 Score=694.06 Aligned_columns=345 Identities=80% Q ss_pred CCCCCHHHHHHHHHHHCCCCCCCCCHHHCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCCCCE Q ss_conf 98741889999876522576661101112574589986598863777775527667888753100022111015787111 Q Ver_Hs_NP_0570 1 MPSETLWEIAKAEVEKRGINGSEGDGAEIAEKFVFFIGSKNGGKTTIILRCLDRDEPPKPTLALEYTYGRRAKGHNTPKD 80 (351) Q Consensus 1 ~~~~~lw~~~~~ev~~~~~~~~~~~~~~~~ek~v~~vGsk~~GKTTli~Rfl~r~e~~KPTlALeYtygRra~~~~~~Kd 80 (351) |||+|||++|.++|++|..++++|+|+|..||+|||||||++||||+|+||++|+|+||||+|||||||||++||++||| T Consensus 10 ~~~e~lw~~A~~~~e~rg~~g~~gdg~e~~e~~~ffiGsk~gGKttiilr~ldrde~~kPtlaLEYtygRr~~g~~~~Kd 89 (397) T PTHR13236 10 MPSETLWEIAKAEVEKRGINGSEGDGAEIAEKFVFFIGSKNGGKTTIILRCLDRDEPPKPTLALEYTYGRRAKGHNTPKD 89 (397) T ss_pred CCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEEECCCCHHHHHHHHHCCCCCCCCCEEEEECHHHHHCCCCCCCC T ss_conf 67665899999999851567541135300101688887348854667765632345678740000001111046888530 Q ss_pred EEEEEEECCCCCHHHCEEEEECCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH Q ss_conf 78889715785420211000042351206778887369846899999999999999999999998526953789999999 Q Ver_Hs_NP_0570 81 IAHFWELGGGTSLLDLISIPITGDTLRTFSLVLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKI 160 (351) Q Consensus 81 vaH~WELGgg~~ls~Li~ipit~~~l~~~~viivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra 160 (351) ||||||||||+++++||+||||.++|+++++++|||||+|+.+|.|+|.+++.++++++++.+++.+++.+...+|+|+. T Consensus 90 iah~WELGGg~~~~~li~iPit~~~l~~~~~~lvLDlS~p~~~w~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~r~~~ 169 (397) T PTHR13236 90 IAHFWELGGGTSLLDLISIPITGDTLRTFSLVLVLDLSKPNDLWPTLENLLQATKSHVDKVLLKLGKTNAKAVSEMRQRI 169 (397) T ss_pred EEEEEECCCCCCHHHHHHHCCCCHHHHHEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_conf 35655317742457786412230125312011044057640024549999999999999999985201356789888888 Q ss_pred HHHCCCCCC---------------------------CCCCCCCCCCCEEEECCEECCCCCCCHHHHHHHHHHHHHHHHHC Q ss_conf 984146677---------------------------60011106887799712100015887667899999999999860 Q Ver_Hs_NP_0570 161 WNNMPKDHP---------------------------DHELIDPFPVPLVIIGSKYDVFQDFESEKRKVICKTLRFVAHYY 213 (351) Q Consensus 161 ~~~~~~dhp---------------------------D~~~v~p~piPlvIVg~KYD~F~~~D~e~rK~i~r~LR~iAH~y 213 (351) |..++++|| |+++++|+|||++|||+|||+|+++|||.||++||+|||+||.+ T Consensus 170 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~p~~~~i~g~kyD~f~~~~~e~rk~~~~~Lr~~ah~~ 249 (397) T PTHR13236 170 WNNMPKDHPVSCCLGLLLESLVPFIVNDNITGNAFPDLELVDPFPIPLVIVGSKYDVFQDFDSEKRKVICRTLRFLAHAY 249 (397) T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHCCCCHHHHHHHHHHHHHHHHHH T ss_conf 74200124689999999988888888877764320235655107811688520110110544678999999999999974 Q ss_pred CCEEEE-EECHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCEEEECCCCCHHHCCCCCCCCCCCCCCCCCCHHHHHHHH Q ss_conf 946888-5120345678999888750577777305750677578705876365668875565310222454236789999 Q Ver_Hs_NP_0570 214 GASLMF-TSKSEALLLKIRGVINQLAFGIDKSKSICVDQNKPLFITAGLDSFGQIGSPPVPENDIGKLHAHSPMELWKKV 292 (351) Q Consensus 214 GA~L~F-tSk~e~l~~r~r~~inhl~FG~~~~k~~~~D~~kPl~I~aG~DS~~~IG~P~~~~~~~g~~~~~~~ldlwk~~ 292 (351) ||+|+| +++.+.+...+|++|||++||....+...+|+++|++|++|.||+.+||.|+++++.++........+++... T Consensus 250 Ga~L~~~s~~~~~l~~~~~~~~~~l~Fg~~~~~~~~~~~~~P~~~~~g~d~~~~~g~p~~~~~~~~~~~~~~~~~~~~~~ 329 (397) T PTHR13236 250 GASLLFLSSKSEALLKKVRGVINHLAFGSPLPKSILVDHNKPLAIPAGLDSLAKIGLPPASGNGIGALLALEVGQLLFKV 329 (397) T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH T ss_conf 36876774225899999999998886303566776520457716870613476606765523578888877788999888 Q ss_pred HHHHCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH Q ss_conf 98637897531234532667788888358899999999999999876765654 Q Ver_Hs_NP_0570 293 YEKLFPPKSINTLKDIKDPARDPQYAENEVDEMRIQKDLELEQYKRSSSKSWK 345 (351) Q Consensus 293 ~~~~fP~k~~~~~k~~~DP~~dp~f~E~~ID~lR~qKd~ELeqy~r~~~~~~~ 345 (351) +...+|.+........+||+.||+|+|+.||++|.||++||+.+.|.....++ T Consensus 330 ~~~~~~~~~~~~~~~~~~~~~~~~~~e~~~D~~r~~k~~~l~~~~~~~~~~~~ 382 (397) T PTHR13236 330 LLPLVPGKSAKLLAKGDDPALDPQFKEAEIDEIRAQKDKELEGLLRELAARGK 382 (397) T ss_pred HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_conf 75421246777765431133100011467789999999999999999999998 No 3 >KOG3905 Dynein light intermediate chain [Cell motility] Probab=100.00 E-value=0 Score=314.78 Aligned_columns=254 Identities=25% Q ss_pred CCHHHHHHHHHHHCCCCCCCCCHHHCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCCCCEEEE Q ss_conf 41889999876522576661101112574589986598863777775527667888753100022111015787111788 Q Ver_Hs_NP_0570 4 ETLWEIAKAEVEKRGINGSEGDGAEIAEKFVFFIGSKNGGKTTIILRCLDRDEPPKPTLALEYTYGRRAKGHNTPKDIAH 83 (351) Q Consensus 4 ~~lw~~~~~ev~~~~~~~~~~~~~~~~ek~v~~vGsk~~GKTTli~Rfl~r~e~~KPTlALeYtygRra~~~~~~KdvaH 83 (351) ++||.+|++||++|.+++.+ +.|+|+++|..++|||||| +-|+..|.+|+..+|||-|....+..++....|+ T Consensus 31 qnlWs~iLsev~T~~~sklp------sgk~VlvlGdn~sGKtsLi-~klqg~e~~KkgsgLeY~yl~V~de~RDd~tr~~ 103 (473) T KOG3905 31 QNLWSEILSEVSTRTRSKLP------SGKNVLVLGDNGSGKTSLI-SKLQGSETVKKGSGLEYLYLHVHDEDRDDLTRCN 103 (473) T ss_pred HHHHHHHHHHHHHCCCCCCC------CCCEEEEEECCCCCHHHHH-HHHHCCCCCCCCCCCEEEEEEECCCCHHHHHHCC T ss_conf 89999998654201234477------8865799705887457898-8763024567765312678862131004465487 Q ss_pred EEEECCCCCHHHCEEEEECCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH Q ss_conf 89715785420211000042351206778887369846899999999999999999999998526953789999999984 Q Ver_Hs_NP_0570 84 FWELGGGTSLLDLISIPITGDTLRTFSLVLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNN 163 (351) Q Consensus 84 ~WELGgg~~ls~Li~ipit~~~l~~~~viivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~ 163 (351) +|.|.|...+..|+...+.+.++....||+++|||+||.+.++|..|.++++.|+|++ +.+++.+++++|+.... T Consensus 104 VWiLDGd~~h~~LLk~al~ats~aetlviltasms~Pw~~lesLqkWa~Vl~ehidkl-----~i~~ee~ka~rqk~~k~ 178 (473) T KOG3905 104 VWILDGDLYHKGLLKFALPATSLAETLVILTASMSNPWTLLESLQKWASVLREHIDKL-----KIPPEEMKAGRQKLEKD 178 (473) T ss_pred CEEECCCHHHHHHHHHCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHH-----CCCHHHHHHHHHHHHHH T ss_conf 1487187555212432046556154589899865750358999999999999989862-----58989999999998888 Q ss_pred CC--------------------CCCCCCCCCCC---------CCCCEEEECCEECCC------CCCCHHHHHHHHHHHHH Q ss_conf 14--------------------66776001110---------688779971210001------58876678999999999 Q Ver_Hs_NP_0570 164 MP--------------------KDHPDHELIDP---------FPVPLVIIGSKYDVF------QDFESEKRKVICKTLRF 208 (351) Q Consensus 164 ~~--------------------~dhpD~~~v~p---------~piPlvIVg~KYD~F------~~~D~e~rK~i~r~LR~ 208 (351) .+ ...-|-+.+-| ||||+++||+|+|+. ++|..|+..+|.+.||- T Consensus 179 wQeYvep~e~~pgsp~~r~t~~~~~~de~~llPL~~dtLt~NlGi~vlVV~TK~D~~s~leke~eyrDehfdfiq~~lRk 258 (473) T KOG3905 179 WQEYVEPGEDQPGSPQRRTTVVGSSADEHVLLPLGQDTLTHNLGIPVLVVCTKCDAVSVLEKEHEYRDEHFDFIQSHLRK 258 (473) T ss_pred HHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHH T ss_conf 89760512478888620343335655311112267762000068747999842430334552010016789999999999 Q ss_pred HHHHCCCEEEEEECHHHHHHH-HHHHHHHHHCCCCCCCEEEEECCCCEEEECCCCCHHHCCC Q ss_conf 998609468885120345678-9998887505777773057506775787058763656688 Q Ver_Hs_NP_0570 209 VAHYYGASLMFTSKSEALLLK-IRGVINQLAFGIDKSKSICVDQNKPLFITAGLDSFGQIGS 269 (351) Q Consensus 209 iAH~yGA~L~FtSk~e~l~~r-~r~~inhl~FG~~~~k~~~~D~~kPl~I~aG~DS~~~IG~ 269 (351) +|..|||+|+|||.+|.++.. ++.+|.|-.||+++.-.+++.+...||||||||+.++|+. T Consensus 259 FCLr~GaaLiyTSvKE~KNidllyKYivhr~yG~~fttpAlVVEkdaVfIPAGWD~eKKI~I 320 (473) T KOG3905 259 FCLRYGAALIYTSVKETKNIDLLYKYIVHRSYGFPFTTPALVVEKDAVFIPAGWDNEKKIDI 320 (473) T ss_pred HHHHCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCHHHEEECCEEEECCCCCCCCHHHH T ss_conf 99860630255411124556888888887641553135001232031463046686300221 No 4 >PF05783 DLIC: Dynein light intermediate chain (DLIC); InterPro: IPR008467 This family consists of several eukaryotic dynein light intermediate chain proteins. The light intermediate chains (LICs) of cytoplasmic dynein consist of multiple isoforms, which undergo post-translational modification to produce a large number of species. DLIC1 is known to be involved in assembly, organisation, and function of centrosomes and mitotic spindles when bound to pericentrin. DLIC2 is a subunit of cytoplasmic dynein 2 that may play a role in maintaining Golgi organisation by binding cytoplasmic dynein 2 to its Golgi-associated cargo .; GO: 0003774 motor activity Probab=100.00 E-value=6.6e-44 Score=301.71 Aligned_columns=255 Identities=26% Q ss_pred CCHHHHHHHHHHHCCCCCCCCCHHHCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCC------ Q ss_conf 41889999876522576661101112574589986598863777775527667888753100022111015787------ Q Ver_Hs_NP_0570 4 ETLWEIAKAEVEKRGINGSEGDGAEIAEKFVFFIGSKNGGKTTIILRCLDRDEPPKPTLALEYTYGRRAKGHNT------ 77 (351) Q Consensus 4 ~~lw~~~~~ev~~~~~~~~~~~~~~~~ek~v~~vGsk~~GKTTli~Rfl~r~e~~KPTlALeYtygRra~~~~~------ 77 (351) ++||..+++||.+|.+++.+ ..|+|+++|..++||||||-|+-+-++..|+---|||.|-...+..++ T Consensus 26 ~~lWs~iL~evst~~~sklp------~gk~vlVLGd~~sGKttLlakLqg~e~~~Kg~gLleY~yl~v~dd~RD~~~~~~ 99 (525) T PF05783_consen 26 ENLWSSILSEVSTRSNSKLP------SGKNVLVLGDNGSGKTTLLAKLQGVEETKKGRGLLEYLYLNVHDDDRDASYAYQ 99 (525) T ss_pred HHHHHHHHHHHHHCCCCCCC------CCCEEEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEEEHHHHHHHHHHH T ss_conf 33889998875412451057------886168861788767899998723443446764111346531101012121000 Q ss_pred -----------CCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHH Q ss_conf -----------111788897157854202110000423512067788873698468999999999999999999999985 Q Ver_Hs_NP_0570 78 -----------PKDIAHFWELGGGTSLLDLISIPITGDTLRTFSLVLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLG 146 (351) Q Consensus 78 -----------~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~viivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~ 146 (351) +...|++|.|.|...+..|+...+.+.++.++.+||++|||+||.+.++|.+|+++++.|++++ T Consensus 100 ~~~~~~~~~p~d~tR~nVWiLdGd~~h~~LLKfAl~~~s~~~tlvilt~dms~PW~~mesLqkW~~Vl~ehi~kL----- 174 (525) T PF05783_consen 100 LGTAGANLNPSDLTRLNVWILDGDAYHKGLLKFALNAESIADTLVILTLDMSRPWNLMESLQKWASVLREHIDKL----- 174 (525) T ss_pred CCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHC----- T ss_conf 000001123331011551576175255555444368544034588887531010358999999999999999605----- Q ss_pred CCCHHHHHHHHHHHHHHCC--------------------CCCCCCCCCCC---------CCCCEEEECCEECCC------ Q ss_conf 2695378999999998414--------------------66776001110---------688779971210001------ Q Ver_Hs_NP_0570 147 KTNAKAVSEMRQKIWNNMP--------------------KDHPDHELIDP---------FPVPLVIIGSKYDVF------ 191 (351) Q Consensus 147 k~~~~~~~~l~qra~~~~~--------------------~dhpD~~~v~p---------~piPlvIVg~KYD~F------ 191 (351) +..++..++|+||.....+ ....|...+.| +|||+++||+|.|.. T Consensus 175 ki~~E~~~~meqrl~k~~QeY~EP~~~~~~sPqrr~~~~~s~~de~v~LPL~~g~Lt~NLGipi~VVctk~D~i~~LeKe 254 (525) T PF05783_consen 175 KIPPEELKEMEQRLVKKFQEYVEPGEDLDGSPQRRTTVVSSSDDESVLLPLGEGTLTENLGIPIIVVCTKSDAISVLEKE 254 (525) T ss_pred CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHC T ss_conf 78989999999999998764316133688884105677875443323266886641147895179985077513444420 Q ss_pred CCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHH-HHHHHHHHHCCCCCCCEEEEECCCCEEEECCCCCHHHCCC Q ss_conf 58876678999999999998609468885120345678-9998887505777773057506775787058763656688 Q Ver_Hs_NP_0570 192 QDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLK-IRGVINQLAFGIDKSKSICVDQNKPLFITAGLDSFGQIGS 269 (351) Q Consensus 192 ~~~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r-~r~~inhl~FG~~~~k~~~~D~~kPl~I~aG~DS~~~IG~ 269 (351) +++..|+..+|.++||-+|..|||+|+|||.++..... .+.+|.|-+||+++.-..++.....||||+|||+.++|+. T Consensus 255 ~d~kdE~fDfIqq~lR~fcL~yGAsLiYTSvKe~kN~dllykYi~HrlYgf~f~~~a~vvekdavfiPaGwDn~kKI~I 333 (525) T PF05783_consen 255 HDYKDEHFDFIQQHLRRFCLQYGASLIYTSVKEEKNIDLLYKYIVHRLYGFPFKTPAQVVEKDAVFIPAGWDNLKKISI 333 (525) T ss_pred CCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCEEEECCCEEECCCCCCHHHHHH T ss_conf 4752778999999999999760740467404552108999999988760775577430341000120367651133344 No 5 >pfam05783 DLIC Dynein light intermediate chain (DLIC). This family consists of several eukaryotic dynein light intermediate chain proteins. The light intermediate chains (LICs) of cytoplasmic dynein consist of multiple isoforms, which undergo post-translational modification to produce a large number of species. DLIC1 is known to be involved in assembly, organisation, and function of centrosomes and mitotic spindles when bound to pericentrin. DLIC2 is a subunit of cytoplasmic dynein 2 that may play a role in maintaining Golgi organisation by binding cytoplasmic dynein 2 to its Golgi-associated cargo. Probab=100.00 E-value=1.2e-43 Score=299.96 Aligned_columns=254 Identities=24% Q ss_pred CCHHHHHHHHHHHCCCCCCCCCHHHCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCCCCEEEE Q ss_conf 41889999876522576661101112574589986598863777775527667888753100022111015787111788 Q Ver_Hs_NP_0570 4 ETLWEIAKAEVEKRGINGSEGDGAEIAEKFVFFIGSKNGGKTTIILRCLDRDEPPKPTLALEYTYGRRAKGHNTPKDIAH 83 (351) Q Consensus 4 ~~lw~~~~~ev~~~~~~~~~~~~~~~~ek~v~~vGsk~~GKTTli~Rfl~r~e~~KPTlALeYtygRra~~~~~~KdvaH 83 (351) ++||..|+.+|.++.+++.+ .+|+|+++|..++|||||| .-|+..+.+|..-||+|+|-...+.+++..-.+| T Consensus 26 ~nLWsSIL~~V~t~~r~Klp------~~KniLVLG~~~~GKttLl-~~Lqg~~~~kkg~aL~Y~YldV~DeD~Dd~~R~~ 98 (475) T pfam05783 26 QNLWSEILSEVSTRTRSKLP------SGKNVLVLGDNGSGKTSLI-SRLQGSERTKKGRGLEYLYLHVHDEDRDDLTRCN 98 (475) T ss_pred HHHHHHHHHHHHCCCCCCCC------CCCEEEEEECCCCCHHHHH-HHHHCCCCCCCCCCCCEEEECCCCCCHHHHCCCC T ss_conf 24789888653025333477------7664788508997557899-9750577667863101346323220303221542 Q ss_pred EEEECCCCCHHHCEEEEECCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH Q ss_conf 89715785420211000042351206778887369846899999999999999999999998526953789999999984 Q Ver_Hs_NP_0570 84 FWELGGGTSLLDLISIPITGDTLRTFSLVLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNN 163 (351) Q Consensus 84 ~WELGgg~~ls~Li~ipit~~~l~~~~viivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~ 163 (351) +|-|.|..+++.||...++++|+.++.|+||||||+||.+.+.|..|+++++.|++++ +.+++...+|++++... T Consensus 99 vwiLd~~~~~~~LLK~aL~~~si~~TlViI~lDms~PW~~i~qL~~Wi~VLrehi~~L-----~i~~ee~~el~e~l~~~ 173 (475) T pfam05783 99 VWILDGDLYHKGLLKFALPATSLAETLVILTASMSNPWTLLESLQKWASVLREHIDKL-----KIPPEEMKAGRQKLEKD 173 (475) T ss_pred EEECCCCCCCCCCCCCCCCCCCHHHHHEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC-----CCCHHHHHHHHHHHHHH T ss_conf 4760875152223212577231422012001212013489999999999999999713-----89988999999999999 Q ss_pred CCC--------------------CCCCCCCCCC---------CCCCEEEECCEECCCC------CCCHHHHHHHHHHHHH Q ss_conf 146--------------------6776001110---------6887799712100015------8876678999999999 Q Ver_Hs_NP_0570 164 MPK--------------------DHPDHELIDP---------FPVPLVIIGSKYDVFQ------DFESEKRKVICKTLRF 208 (351) Q Consensus 164 ~~~--------------------dhpD~~~v~p---------~piPlvIVg~KYD~F~------~~D~e~rK~i~r~LR~ 208 (351) .+. ...|.++..| +|||+|+||+|.|... ++.-|+..+|.+.||- T Consensus 174 wqeY~epg~~~d~s~~r~t~~~~~~~~~~v~lPLgeg~Lt~NLGiPiiVVctKsD~ie~LEKe~~ykeE~fDfIqq~LR~ 253 (475) T pfam05783 174 WQEYVEPGEDLDGSPQRRTSVVGSFDEEHVLLPLGQDTLTHNLGLPVLVVCTKCDAMSVLEKEHDYRDEHFDFIQSHLRK 253 (475) T ss_pred HHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCEEEEEEEECCCHHHHHHCCCCCCHHHHHHHHHHHHH T ss_conf 99860553467877632456656534445657788763412788269998617621333320156643679999999999 Q ss_pred HHHHCCCEEEEEECHHHHHHH-HHHHHHHHHCCCCCCCEEEEECCCCEEEECCCCCHHHCCC Q ss_conf 998609468885120345678-9998887505777773057506775787058763656688 Q Ver_Hs_NP_0570 209 VAHYYGASLMFTSKSEALLLK-IRGVINQLAFGIDKSKSICVDQNKPLFITAGLDSFGQIGS 269 (351) Q Consensus 209 iAH~yGA~L~FtSk~e~l~~r-~r~~inhl~FG~~~~k~~~~D~~kPl~I~aG~DS~~~IG~ 269 (351) +|-.|||+|+|||-++..+.. .+.+|-|-+||+++.-..++.....||||+|||+|.+|+. T Consensus 254 ~cLqYGAsLiYTS~ke~kNldlLykYl~HrlYgfpf~~~a~VvekDaIfIPsGWDn~kKI~I 315 (475) T pfam05783 254 FCLQYGAALIYTSVKETKNIDLLYKYIVHRSYGFPFTTPALVVEKDAVFIPAGWDNEKKIDI 315 (475) T ss_pred HHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEHHEEEECCCCCCHHHHHH T ss_conf 99870975898547764238999999998860765456220010000340588881455675 No 6 >PTHR12688 DYNEIN LIGHT INTERMEDIATE CHAIN; InterPro: IPR008467 This family consists of several eukaryotic dynein light intermediate chain proteins. The light intermediate chains (LICs) of cytoplasmic dynein consist of multiple isoforms, which undergo post-translational modification to produce a large number of species. DLIC1 is known to be involved in assembly, organisation, and function of centrosomes and mitotic spindles when bound to pericentrin. DLIC2 is a subunit of cytoplasmic dynein 2 that may play a role in maintaining Golgi organisation by binding cytoplasmic dynein 2 to its Golgi-associated cargo .; GO: 0003774 motor activity. Probab=99.97 E-value=2.7e-31 Score=221.58 Aligned_columns=201 Identities=27% Q ss_pred CCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH Q ss_conf 10002211101578711178889715785420211000042351206778887369846899999999999999999999 Q Ver_Hs_NP_0570 63 ALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSLVLVLDLSKPNDLWPTMENLLQATKSHVDKVI 142 (351) Q Consensus 63 ALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~viivlDlSkP~~lw~tle~~l~~vr~~v~kl~ 142 (351) +|||.|...++.++.....|+||-|.|...+..||...+.+.++....|+||+|||+|+.+.++|.+|+++++.|++++ T Consensus 1 g~~Y~y~~v~d~d~d~~~r~~vW~Ldgd~~~~gLlk~a~~~~s~~~tl~~~~~dm~~PW~~~~~L~~W~~v~~~~~~kl- 79 (415) T PTHR12688 1 GLEYLYLNVHDEDRDDLTRCNVWILDGDLYHKGLLKFALSAESLPDTLVILVADMSKPWTVMDSLQKWASVLREHIDKL- 79 (415) T ss_pred CCCHHHHHHHHCCHHHHHHCCCEEECCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH- T ss_conf 9201322011036013432101034352767778886317301789999999987225579999999999999999873- Q ss_pred HHHHCCCHHHHHHHHHHHHHHCCCCCC--------------CCCCCCC---------CCCCEEEECCEECCC------CC Q ss_conf 998526953789999999984146677--------------6001110---------688779971210001------58 Q Ver_Hs_NP_0570 143 MKLGKTNAKAVSEMRQKIWNNMPKDHP--------------DHELIDP---------FPVPLVIIGSKYDVF------QD 193 (351) Q Consensus 143 ~~l~k~~~~~~~~l~qra~~~~~~dhp--------------D~~~v~p---------~piPlvIVg~KYD~F------~~ 193 (351) +..+..+.++.++..+..+.-.+ |-....| ||+|+++||+|.|.. ++ T Consensus 80 ----~i~~~~~~~~~~~~~~~~q~y~e~~~~~~~s~~~~~~d~~~~lp~~~~~lt~nlG~~~~vV~~k~d~~~~L~ke~d 155 (415) T PTHR12688 80 ----KIPPEEMKELEQKLVKDFQEYVEPGEGLPGSPLRRNADELVPLPLGEGTLTHNLGIPVVVVCTKSDAMSVLEKEHD 155 (415) T ss_pred ----CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHCCCEEEEEEECCHHHHHHHHHCC T ss_conf ----3888899999999999754210200133334201123444312341246776379169998741315788754303 Q ss_pred CCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHH-HHHHHHHHHCCCCCCCEEEEECCCCEEEECCCCCHHHCC Q ss_conf 876678999999999998609468885120345678-999888750577777305750677578705876365668 Q Ver_Hs_NP_0570 194 FESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLK-IRGVINQLAFGIDKSKSICVDQNKPLFITAGLDSFGQIG 268 (351) Q Consensus 194 ~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r-~r~~inhl~FG~~~~k~~~~D~~kPl~I~aG~DS~~~IG 268 (351) |..|+..+|.+.||-+|..|||+|+|||-+|.++.. ++.+|.|..||++......+.....||||||||+.++|+ T Consensus 156 yrdehfDfiq~~lR~fcL~yga~L~ytsvke~kN~dLlykYivh~~yGf~f~~~a~VvekdavfiPaGWD~~kKI~ 231 (415) T PTHR12688 156 YRDEHFDFIQSHLRKFCLQYGAALIYTSVKEEKNIDLLYKYIVHKLYGFPFTIPALVVEKDAVFIPAGWDNEKKIG 231 (415) T ss_pred CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHEEEEEEEEECCCCCCHHHHH T ss_conf 1288999999999999998402531101001334899999998886065434401112200045168988077889 No 7 >cd04128 Spg1 Spg1p. Spg1p (septum-promoting GTPase) was first identified in the fission yeast S. pombe, where it regulates septum formation in the septation initiation network (SIN) through the cdc7 protein kinase. Spg1p is an essential gene that localizes to the spindle pole bodies. When GTP-bound, it binds cdc7 and causes it to translocate to spindle poles. Sid4p (septation initiation defective) is required for localization of Spg1p to the spindle pole body, and the ability of Spg1p to promote septum formation from any point in the cell cycle depends on Sid4p. Spg1p is negatively regulated by Byr4 and cdc16, which form a two-component GTPase activating protein (GAP) for Spg1p. The existence of a SIN-related pathway in plants has been proposed. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are Probab=99.59 E-value=7.4e-14 Score=110.87 Aligned_columns=177 Identities=21% Q ss_pred EEEEECCCCCHHHHHHHHCCC--CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 899865988637777755276--678887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDR--DEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r--~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |++||+.+.|||||++||+.. .+.+.||.+++|.--.-...++.. ..++|..+|--.+..+...-.+ ....+ T Consensus 3 ivliGd~~VGKTsLi~r~~~~~F~~~y~~TiG~~~~~k~i~v~~~~v--~l~iwDtaGqE~f~~~~~~y~~----~a~~~ 76 (182) T cd04128 3 IGLLGDAQIGKTSLMVKYVEGEFDEDYIQTLGVNFMEKTISIRGTEI--TFSIWDLGGQREFINMLPLVCN----DAVAI 76 (182) T ss_pred EEEEECCCCCHHHHHHHHHCCEECCCCCCEEEEEEEEEEEEECCEEE--EEEEEECCCCCCCHHHHHHHCC----CCCEE T ss_conf 89981698438888777643712776355034467898999889689--9887316888310127786403----77768 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) +||.|++.+.++ +.+..|++.++.+... ++| ++||+|+|+. T Consensus 77 ilVfDit~~~Sf-~~i~~W~~~i~~~~~~-------------------------------------~~~-ILVGNK~DL~ 117 (182) T cd04128 77 LFMFDLTRKSTL-NSIKEWYRQARGFNKT-------------------------------------AIP-ILVGTKYDLF 117 (182) T ss_pred EEEEECCCHHHH-HHHHHHHHHHHHHCCC-------------------------------------CCE-EEEECCCCCC T ss_conf 999865997899-9999999999862799-------------------------------------608-9983274310 Q ss_pred CCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHH-HHHHHHHHHCCCCCCCEEEEECCCCE Q ss_conf 58876678999999999998609468885120345678-99988875057777730575067757 Q Ver_Hs_NP_0570 192 QDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLK-IRGVINQLAFGIDKSKSICVDQNKPL 255 (351) Q Consensus 192 ~~~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r-~r~~inhl~FG~~~~k~~~~D~~kPl 255 (351) .+.+++.+..+..-.+-.|-.+|+.++++|-+...... .=..+-..+|..+...+-.+.--.|+ T Consensus 118 ~~~~~~~~~~~~~~~~~~a~~~~~~~~etSAktg~nV~e~Fe~l~~ki~~~~~~~~~~~~~~~~~ 182 (182) T cd04128 118 ADLPPEEQEEITKQARKYAKAMKAPLIFCSTSHSINVQKIFKIVLAKAFDLPLTIPEILTVGEPI 182 (182) T ss_pred CCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCC T ss_conf 01442456778899999999729959999724798878999999999853788877668888899 No 8 >cd01860 Rab5_related Rab5-related subfamily. This subfamily includes Rab5 and Rab22 of mammals, Ypt51/Ypt52/Ypt53 of yeast, and RabF of plants. The members of this subfamily are involved in endocytosis and endocytic-sorting pathways. In mammals, Rab5 GTPases localize to early endosomes and regulate fusion of clathrin-coated vesicles to early endosomes and fusion between early endosomes. In yeast, Ypt51p family members similarly regulate membrane trafficking through prevacuolar compartments. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site at the C-terminus, with sequence mo Probab=99.47 E-value=9.2e-13 Score=103.94 Aligned_columns=153 Identities=18% Q ss_pred EEEEECCCCCHHHHHHHHCCC--CCCCCCCCCCCHHHHHHHCCCCCCCEEE-EEEEECCCCCHHHCEEEEECCCCCCEEE Q ss_conf 899865988637777755276--6788875310002211101578711178-8897157854202110000423512067 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDR--DEPPKPTLALEYTYGRRAKGHNTPKDIA-HFWELGGGTSLLDLISIPITGDTLRTFS 110 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r--~e~~KPTlALeYtygRra~~~~~~Kdva-H~WELGgg~~ls~Li~ipit~~~l~~~~ 110 (351) |++||+.|+||||||.||+.. .+.+.||++.+| +...-....+.+- ++|..+|...+..|...-++. .-. T Consensus 4 i~iiG~~gvGKTsli~r~~~~~f~~~~~pTig~~~---~~k~i~~~~~~v~l~i~Dt~G~e~~~~l~~~~~~~----a~~ 76 (163) T cd01860 4 LVLLGDSSVGKSSLVLRFVKNEFSENQESTIGAAF---LTQTVNLDDTTVKFEIWDTAGQERYRSLAPMYYRG----AAA 76 (163) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCEE---EEEEEEECCEEEEEEEECCCCCHHHHHHHHHHHCC----CCE T ss_conf 99981699658999998862833755351013225---68899888879999970489831245666765138----884 Q ss_pred EEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECC Q ss_conf 78887369846899999999999999999999998526953789999999984146677600111068877997121000 Q Ver_Hs_NP_0570 111 LVLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDV 190 (351) Q Consensus 111 viivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~ 190 (351) ++||.|++.+.++=. +..|++.++++... .+|++|||+|.|. T Consensus 77 ~ilvydit~~~Sf~~-i~~w~~~i~~~~~~-------------------------------------~~~iilVgNK~Dl 118 (163) T cd01860 77 AIVVYDITSEESFEK-AKSWVKELQRNASP-------------------------------------NIIIALVGNKADL 118 (163) T ss_pred EEEEEECCCHHHHHH-HHHHHHHHHHHCCC-------------------------------------CCEEEEEECCHHH T ss_conf 999986599789999-99988765530699-------------------------------------9589998322105 Q ss_pred CCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHH Q ss_conf 158876678999999999998609468885120345678999888750 Q Ver_Hs_NP_0570 191 FQDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLA 238 (351) Q Consensus 191 F~~~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r~r~~inhl~ 238 (351) .++|.+--.-.+.+|-.+|+..+.+|-++. ..+..+..+++ T Consensus 119 -----~~~r~v~~~e~~~~a~~~~~~~~e~SAk~~--~nI~~~F~~l~ 159 (163) T cd01860 119 -----ESKRQVSTEEAQEYADENGLLFFETSAKTG--ENVNELFTEIA 159 (163) T ss_pred -----HHCCCCCHHHHHHHHHHCCCEEEEEECCCC--CCHHHHHHHHH T ss_conf -----430588789999999965992999971489--88889999999 No 9 >cd04106 Rab23_lke Rab23-like subfamily. Rab23 is a member of the Rab family of small GTPases. In mouse, Rab23 has been shown to function as a negative regulator in the sonic hedgehog (Shh) signalling pathway. Rab23 mediates the activity of Gli2 and Gli3, transcription factors that regulate Shh signaling in the spinal cord, primarily by preventing Gli2 activation in the absence of Shh ligand. Rab23 also regulates a step in the cytoplasmic signal transduction pathway that mediates the effect of Smoothened (one of two integral membrane proteins that are essential components of the Shh signaling pathway in vertebrates). In humans, Rab23 is expressed in the retina. Mice contain an isoform that shares 93% sequence identity with the human Rab23 and an alternative splicing isoform that is specific to the brain. This isoform causes the murine open brain phenotype, indicating it may have a role in the development of the central nervous system. GTPase activating proteins (GAPs) interact with G Probab=99.47 E-value=1.7e-12 Score=102.24 Aligned_columns=155 Identities=18% Q ss_pred EEEEECCCCCHHHHHHHHCCC--CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 899865988637777755276--678887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDR--DEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r--~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |+++|+.|.|||||+.||+.. .+.+.||++.+|.--......+...=-.++|..+|.-.+..+...-++..+ .+ T Consensus 3 i~~iGd~~vGKTsli~r~~~~~f~~~~~~Tig~~~~~k~v~v~~~~~~v~l~iwDt~g~e~~~~~~~~~~~~~~----~~ 78 (162) T cd04106 3 VIVVGNGNVGKSSMIQRFVKGIFTKDYKKTIGVDFLEKQIFLRQSDEDVRLMLWDTAGQEEFDAITKAYYRGAQ----AC 78 (162) T ss_pred EEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEEEECCEEEEEEEECCCCCCHHHHHHHHHCCCCC----EE T ss_conf 89980798448999999862822755564101046777899700884799998718888003455376414897----89 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) +||.|++.++++ +.++.|++.++..... +|+++||+|.|.. T Consensus 79 llvydvt~~~Sf-~~i~~w~~~i~~~~~~--------------------------------------~p~ilVGNK~Dl~ 119 (162) T cd04106 79 ILVFSTTDRESF-EAIESWKEKVEAECGD--------------------------------------IPMVLVQTKIDLL 119 (162) T ss_pred EEEEECCCHHHH-HHHHHHHHHHHHHCCC--------------------------------------CEEEEEECCCCCC T ss_conf 999866997899-9999999999985499--------------------------------------3799982142321 Q ss_pred CCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHH Q ss_conf 58876678999999999998609468885120345678999888750 Q Ver_Hs_NP_0570 192 QDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLA 238 (351) Q Consensus 192 ~~~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r~r~~inhl~ 238 (351) .+ |.+.-+-.+.+|..+|+..+.+|-++. ..+..+..+|+ T Consensus 120 ~~-----~~vs~~~~~~~a~~~~~~~~E~SAk~~--~nV~e~F~~la 159 (162) T cd04106 120 DQ-----AVITNEEAEALAKRLQLPLFRTSVKDD--FNVTELFEYLA 159 (162) T ss_pred CC-----CCCCHHHHHHHHHHCCCCEEEEECCCC--CCHHHHHHHHH T ss_conf 24-----658989999999966995999971589--88789999998 No 10 >cd00154 Rab Rab family. Rab GTPases form the largest family within the Ras superfamily. There are at least 60 Rab genes in the human genome, and a number of Rab GTPases are conserved from yeast to humans. Rab GTPases are small, monomeric proteins that function as molecular switches to regulate vesicle trafficking pathways. The different Rab GTPases are localized to the cytosolic face of specific intracellular membranes, where they regulate distinct steps in membrane traffic pathways. In the GTP-bound form, Rab GTPases recruit specific sets of effector proteins onto membranes. Through their effectors, Rab GTPases regulate vesicle formation, actin- and tubulin-dependent vesicle movement, and membrane fusion. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide di Probab=99.46 E-value=1.6e-12 Score=102.39 Aligned_columns=154 Identities=23% Q ss_pred EEEEECCCCCHHHHHHHHCCC--CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 899865988637777755276--678887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDR--DEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r--~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |.+||+.|.||||||+|++.. .+.+.||++.+|..-.-...+... -..+|..+|...+..|.+..++. .-.+ T Consensus 3 i~ivG~~~vGKTsli~~~~~~~f~~~~~~Ti~~~~~~k~i~~~~~~~--~~~i~Dt~g~e~~~~~~~~~~~~----~d~~ 76 (159) T cd00154 3 IVLIGDSGVGKTSLLLRFVDGKFDENYKSTIGVDFKSKTIEIDGKTV--KLQIWDTAGQERFRSITPSYYRG----AHGA 76 (159) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEECCEEE--EEEEEECCCCHHHHHHHHHHCCC----CCEE T ss_conf 89982699668999999863824744465310036888998889599--99998659971456777875148----9869 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) ++|+|++++.++ ..++.|++.++++... .+|++|||+|+|+ T Consensus 77 iiv~d~~~~~Sf-~~i~~~~~~i~~~~~~-------------------------------------~~piiivgnK~Dl- 117 (159) T cd00154 77 ILVYDITNRESF-ENLDKWLKELKEYAPE-------------------------------------NIPIILVGNKIDL- 117 (159) T ss_pred EEEEECCCHHHH-HHHHHHHHHHHHHCCC-------------------------------------CCEEEEEECCCCH- T ss_conf 999866997899-9999999999982699-------------------------------------9789998413100- Q ss_pred CCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHH Q ss_conf 58876678999999999998609468885120345678999888750 Q Ver_Hs_NP_0570 192 QDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLA 238 (351) Q Consensus 192 ~~~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r~r~~inhl~ 238 (351) .+++.+...-.+.+|..+++..+.+|-+.. ..+..+...++ T Consensus 118 ----~~~~~v~~~~~~~~~~~~~~~~~e~Sa~~~--~~i~~~F~~i~ 158 (159) T cd00154 118 ----EDQRQVSTEEAQQFAKENGLLFFETSAKTG--ENVEELFQSLA 158 (159) T ss_pred ----HHHCCCCHHHHHHHHHHCCCCEEEEEECCC--CCHHHHHHHHC T ss_conf ----010265688999999965996999970479--88789999970 No 11 >cd01867 Rab8_Rab10_Rab13_like Rab8/Sec4/Ypt2. Rab8/Sec4/Ypt2 are known or suspected to be involved in post-Golgi transport to the plasma membrane. It is likely that these Rabs have functions that are specific to the mammalian lineage and have no orthologs in plants. Rab8 modulates polarized membrane transport through reorganization of actin and microtubules, induces the formation of new surface extensions, and has an important role in directed membrane transport to cell surfaces. The Ypt2 gene of the fission yeast Schizosaccharomyces pombe encodes a member of the Ypt/Rab family of small GTP-binding proteins, related in sequence to Sec4p of Saccharomyces cerevisiae but closer to mammalian Rab8. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhi Probab=99.46 E-value=1.5e-12 Score=102.62 Aligned_columns=154 Identities=21% Q ss_pred EEEEECCCCCHHHHHHHHCCC--CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 899865988637777755276--678887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDR--DEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r--~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |+++|+.+.||||||.||+.. .+.+.||.+.+|..-.....+... -.++|..+|--.+..+-...++.-+ .+ T Consensus 6 i~liGd~~vGKTsli~r~~~~~f~~~~~~Tig~~~~~k~v~~~~~~v--~l~iwDt~G~e~~~~~~~~~~~~a~----~~ 79 (167) T cd01867 6 LLLIGDSGVGKSCLLLRFSEDSFNPSFISTIGIDFKIRTIELDGKKI--KLQIWDTAGQERFRTITTAYYRGAM----GI 79 (167) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEEECCEEE--EEEEEECCCCCHHHHHHHHHCCCCC----EE T ss_conf 99982698438999988763810765564121256788999889499--9999866898002345375436998----89 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) +||.|++.+.++ +.++.|++.++++..+ -+|++|||+|.|+ T Consensus 80 iivfDit~~~Sf-~~i~~w~~~i~~~~~~-------------------------------------~~~~ilVGNK~DL- 120 (167) T cd01867 80 ILVYDITDEKSF-ENIRNWMRNIEEHASE-------------------------------------DVERMLVGNKCDM- 120 (167) T ss_pred EEEEECCCHHHH-HHHHHHHHHHHHHCCC-------------------------------------CCEEEEEEECCCC- T ss_conf 999856984678-9999999999852699-------------------------------------9389999404675- Q ss_pred CCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHH Q ss_conf 58876678999999999998609468885120345678999888750 Q Ver_Hs_NP_0570 192 QDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLA 238 (351) Q Consensus 192 ~~~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r~r~~inhl~ 238 (351) +++|.+-..-.+-+|-.+|+..+.+|-+.. ..+..+..+++ T Consensus 121 ----~~~r~v~~~~~~~~a~~~~~~~~e~SAk~~--~nv~~~F~~l~ 161 (167) T cd01867 121 ----EEKRVVSKEEGEALADEYGIKFLETSAKAN--INVEEAFFTLA 161 (167) T ss_pred ----CCCCCCCHHHHHHHHHHCCCCEEEEEECCC--CCHHHHHHHHH T ss_conf ----222466989999999964995999970489--78789999999 No 12 >cd04110 Rab35 Rab35 subfamily. Rab35 is one of several Rab proteins to be found to participate in the regulation of osteoclast cells in rats. In addition, Rab35 has been identified as a protein that interacts with nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) in human cells. Overexpression of NPM-ALK is a key oncogenic event in some anaplastic large-cell lymphomas; since Rab35 interacts with N|PM-ALK, it may provide a target for cancer treatments. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site at the C-terminus, with sequence motifs CC, CXC, or CCX. Lipid binding is Probab=99.46 E-value=2.2e-12 Score=101.47 Aligned_columns=153 Identities=24% Q ss_pred EEEEECCCCCHHHHHHHHCCC--CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 899865988637777755276--678887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDR--DEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r--~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |+++|+.|.||||||.||+.. .+.+.||++.+|..-.-.-.+... ..++|..+|-..+..|...-++. .-.+ T Consensus 9 vv~iGd~~VGKTsli~r~~~~~F~~~y~~Tig~~~~~k~v~i~~~~~--~l~iwDtaGqe~~~~l~~~y~~~----a~~~ 82 (199) T cd04110 9 LLIIGDSGVGKSSLLLRFADNTFSGSYITTIGVDFKIRTVEINGERV--KLQIWDTAGQERFRTITSTYYRG----THGV 82 (199) T ss_pred EEEEECCCCCHHHHHHHHHCCEECCCCCCCEEEEEEEEEEEECCEEE--EEEEEECCCCCHHHHHHHHHCCC----CCEE T ss_conf 99982698438999988761800766465112235788899858399--99998669970356776765038----9879 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) +||.|++.++++ +.+..|++.+++..+. +|+++||+|.| T Consensus 83 ilVydit~~~Sf-~~i~~w~~~i~~~~~~--------------------------------------~~~iLVGNK~D-- 121 (199) T cd04110 83 IVVYDVTNGESF-VNVKRWLQEIEQNCDD--------------------------------------VCKVLVGNKND-- 121 (199) T ss_pred EEEEECCCHHHH-HHHHHHHHHHHHHCCC--------------------------------------CCEEEEEECCC-- T ss_conf 999877997799-9999999999851256--------------------------------------73699840336-- Q ss_pred CCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHH Q ss_conf 58876678999999999998609468885120345678999888750 Q Ver_Hs_NP_0570 192 QDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLA 238 (351) Q Consensus 192 ~~~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r~r~~inhl~ 238 (351) .+++|.+.-.-.+.+|-.+|+..+.+|-+.. ..+-.+...++ T Consensus 122 ---l~~~r~v~~ee~~~~a~~~~~~f~EtSAktg--~nV~e~F~~i~ 163 (199) T cd04110 122 ---DPERKVVETEDAYKFAGQMGISLFETSAKEN--INVEEMFNCIT 163 (199) T ss_pred ---CHHHCCCCHHHHHHHHHHCCCCEEEEECCCC--CCHHHHHHHHH T ss_conf ---3112265689999999966995999971589--88889999999 No 13 >cd00876 Ras Ras family. The Ras family of the Ras superfamily includes classical N-Ras, H-Ras, and K-Ras, as well as R-Ras, Rap, Ral, Rheb, Rhes, ARHI, RERG, Rin/Rit, RSR1, RRP22, Ras2, Ras-dva, and RGK proteins. Ras proteins regulate cell growth, proliferation and differentiation. Ras is activated by guanine nucleotide exchange factors (GEFs) that release GDP and allow GTP binding. Many RasGEFs have been identified. These are sequestered in the cytosol until activation by growth factors triggers recruitment to the plasma membrane or Golgi, where the GEF colocalizes with Ras. Active GTP-bound Ras interacts with several effector proteins: among the best characterized are the Raf kinases, phosphatidylinositol 3-kinase (PI3K), RalGEFs and NORE/MST1. Most Ras proteins contain a lipid modification site at the C-terminus, with a typical sequence motif CaaX, where a = an aliphatic amino acid and X = any amino acid. Lipid binding is essential for membrane attachment, a key feature of m Probab=99.46 E-value=1.7e-12 Score=102.29 Aligned_columns=154 Identities=21% Q ss_pred EEEEECCCCCHHHHHHHHCCC--CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 899865988637777755276--678887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDR--DEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r--~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |++||+.|+||||||+||+.. .+...||++-.|.--..-.+++- ..++|..+|.-.+..+...-++.-. .+ T Consensus 2 i~~iGd~~vGKTsli~r~~~~~f~~~~~~ti~~~~~k~~~~~~~~~---~l~i~Dt~G~e~~~~~~~~~~~~a~----~~ 74 (160) T cd00876 2 VVVLGAGGVGKSAITIQFVKGTFVEEYDPTIEDSYRKTIVVDGETY---TLDILDTAGQEEFSAMRDLYIRQGD----GF 74 (160) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCHHHEEEEEEEECCEEE---EEEEEECCCCHHHHHHHHHHHCCCC----EE T ss_conf 7888079966899999987281067535420022677888848289---9998635884133468887640461----78 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) +||+|++.+.+ ++.+..|++.+++.... -.+|+++||+|+|+ T Consensus 75 iivfdi~~~~S-f~~i~~w~~~i~~~~~~------------------------------------~~~piilvgNK~Dl- 116 (160) T cd00876 75 ILVYSITDRES-FEEIKGYREQILRVKDD------------------------------------EDIPIVLVGNKCDL- 116 (160) T ss_pred EEEEECCCHHH-HHHHHHHHHHHHHHCCC------------------------------------CCCEEEEEECCCCC- T ss_conf 99986699779-99999999999985389------------------------------------99679998213263- Q ss_pred CCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHH Q ss_conf 58876678999999999998609468885120345678999888750 Q Ver_Hs_NP_0570 192 QDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLA 238 (351) Q Consensus 192 ~~~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r~r~~inhl~ 238 (351) ++.|++...-.+.+|+.+|+..+.+|-+.. ..+..+..+++ T Consensus 117 ----~~~r~v~~~e~~~~a~~~~~~~~e~Sak~~--~nV~~~F~~i~ 157 (160) T cd00876 117 ----ENERQVSKEEGKALAKEWGCPFIETSAKDN--INIDEVFKLLV 157 (160) T ss_pred ----HHHCCCCHHHHHHHHHHCCCCEEEEEECCC--CCHHHHHHHHH T ss_conf ----001167688999999964996999970489--88889999999 No 14 >cd04109 Rab28 Rab28 subfamily. First identified in maize, Rab28 has been shown to be a late embryogenesis-abundant (Lea) protein that is regulated by the plant hormone abcisic acid (ABA). In Arabidopsis, Rab28 is expressed during embryo development and is generally restricted to provascular tissues in mature embryos. Unlike maize Rab28, it is not ABA-inducible. Characterization of the human Rab28 homolog revealed two isoforms, which differ by a 95-base pair insertion, producing an alternative sequence for the 30 amino acids at the C-terminus. The two human isoforms are presumbly the result of alternative splicing. Since they differ at the C-terminus but not in the GTP-binding region, they are predicted to be targeted to different cellular locations. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs Probab=99.44 E-value=5e-12 Score=99.27 Aligned_columns=158 Identities=20% Q ss_pred EEEEECCCCCHHHHHHHHCCC--CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 899865988637777755276--678887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDR--DEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r--~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |+++|+.+.|||||+.||+.. .+.+.||+++|| |-+...-....+-..++|..+|-.....+.+..+...+ .+ T Consensus 3 VvliGd~~VGKTSLi~rf~~~~F~~~y~~Tig~d~-~~k~i~i~~~~~v~l~iwDtaGqe~~~~~~~~y~~~a~----~~ 77 (215) T cd04109 3 IVVLGDGAVGKTSLCRRFAKEGFGKSYKQTIGLDF-FSKRVTLPGNLNVTLQVWDIGGQSIGGKMLDKYIYGAH----AV 77 (215) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEE-EEEEEEECCCCEEEEEEEECCCCCHHHHHHHHHHCCCC----EE T ss_conf 89982698538999988770721776465145678-78999975860589999864773023688998705998----48 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) +||.|++.+ .=++.++.|++.+++.... ...++|++|||+|.|+ T Consensus 78 ilVYdIt~~-~SF~~i~~W~~~i~~~~~~----------------------------------~~~~~~iiLVGNK~DL- 121 (215) T cd04109 78 FLVYDVTNS-QSFENLEDWYSMVRKVLKS----------------------------------SETQPLVVLVGNKTDL- 121 (215) T ss_pred EEEEECCCH-HHHHHHHHHHHHHHHHHHC----------------------------------CCCCCEEEEECCCCCH- T ss_conf 999753897-6899999999999987310----------------------------------5898189996054240- Q ss_pred CCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHH Q ss_conf 58876678999999999998609468885120345678999888750 Q Ver_Hs_NP_0570 192 QDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLA 238 (351) Q Consensus 192 ~~~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r~r~~inhl~ 238 (351) .+.|.+-..--+.+|-.+|+..+++|-+.. .++..+-.+++ T Consensus 122 ----~~~R~Vs~ee~~~~A~~~~~~f~EvSAktg--~nV~elF~~la 162 (215) T cd04109 122 ----EHNRTVKDDKHARFAQANGMESCLVSAKTG--DRVNLLFQQLA 162 (215) T ss_pred ----HHCCCCCHHHHHHHHHHCCCCEEEEECCCC--CCHHHHHHHHH T ss_conf ----120667989999999964995999962679--88889999999 No 15 >cd01865 Rab3 Rab3 subfamily. The Rab3 subfamily contains Rab3A, Rab3B, Rab3C, and Rab3D. All four isoforms were found in mouse brain and endocrine tissues, with varying levels of expression. Rab3A, Rab3B, and Rab3C localized to synaptic and secretory vesicles; Rab3D was expressed at high levels only in adipose tissue, exocrine glands, and the endocrine pituitary, where it is localized to cytoplasmic secretory granules. Rab3 appears to control Ca2+-regulated exocytosis. The appropriate GDP/GTP exchange cycle of Rab3A is required for Ca2+-regulated exocytosis to occur, and interaction of the GTP-bound form of Rab3A with effector molecule(s) is widely believed to be essential for this process. Functionally, most studies point toward a role for Rab3 in the secretion of hormones and neurotransmitters. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promot Probab=99.44 E-value=5.6e-12 Score=98.95 Aligned_columns=154 Identities=19% Q ss_pred EEEEECCCCCHHHHHHHHCCC--CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 899865988637777755276--678887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDR--DEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r--~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |++||+.+.||||||.||++. .+.+.||++.+|..-.-...+... -.++|..+|.-.+..+.....+.-. .+ T Consensus 4 iilvGd~~VGKTsli~rf~~~~f~~~y~~Ti~~~~~~k~i~~~~~~v--~l~iwDt~G~e~~~~~~~~~~~~~~----~~ 77 (165) T cd01865 4 LLIIGNSSVGKTSFLFRYADDSFTSAFVSTVGIDFKVKTVFRNDKRV--KLQIWDTAGQERYRTITTAYYRGAM----GF 77 (165) T ss_pred EEEEECCCCCHHHHHHHHHCCEECCCCCCCEEEEEEEEEEEECCEEE--EEEEEECCCCCHHHHHHHHHCCCCC----EE T ss_conf 99980799538998887644810666343036567899998779389--9999745887013456564336998----89 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) +||.|++.+.++ ..++.|++.+++.... .+|+++||+|.|+ T Consensus 78 iivfd~t~~~Sf-~~i~~w~~~i~~~~~~-------------------------------------~~~iilVGNK~Dl- 118 (165) T cd01865 78 ILMYDITNEESF-NAVQDWSTQIKTYSWD-------------------------------------NAQVILVGNKCDM- 118 (165) T ss_pred EEEEECCCHHHH-HHHHHHHHHHHHHCCC-------------------------------------CEEEEEEECCCCH- T ss_conf 999866986689-9999999999860699-------------------------------------6089997217772- Q ss_pred CCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHH Q ss_conf 58876678999999999998609468885120345678999888750 Q Ver_Hs_NP_0570 192 QDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLA 238 (351) Q Consensus 192 ~~~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r~r~~inhl~ 238 (351) .++|.+-..-.+-+|-.+|...+.+|-+.. .++..+..+++ T Consensus 119 ----~~~r~v~~~~~~~~a~~~~~~y~EtSAk~~--~nV~e~F~~l~ 159 (165) T cd01865 119 ----EDERVVSSERGRQLADQLGFEFFEASAKEN--INVKQVFERLV 159 (165) T ss_pred ----HHHHHHHHHHHHHHHHHCCCCEEEEECCCC--CCHHHHHHHHH T ss_conf ----465531388999999965994999971589--88789999999 No 16 >cd01869 Rab1_Ypt1 Rab1/Ypt1 subfamily. Rab1 is found in every eukaryote and is a key regulatory component for the transport of vesicles from the ER to the Golgi apparatus. Studies on mutations of Ypt1, the yeast homolog of Rab1, showed that this protein is necessary for the budding of vesicles of the ER as well as for their transport to, and fusion with, the Golgi apparatus. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site at the C-terminus, with sequence motifs CC, CXC, or CCX. Lipid binding is essential for membrane attachment, a key feature of most Rab proteins. Due to t Probab=99.44 E-value=2.9e-12 Score=100.78 Aligned_columns=154 Identities=21% Q ss_pred EEEEECCCCCHHHHHHHHCCC--CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 899865988637777755276--678887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDR--DEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r--~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |+++|+.|.||||||.||+.. .+.+.||++-+|..-.-...+... -.++|..+|......|.+.-+. ..-.+ T Consensus 5 iv~vGd~~vGKTsli~r~~~~~f~~~y~~Tig~~~~~k~i~~~~~~v--~l~iwDt~G~e~~~~l~~~~~~----~a~~~ 78 (166) T cd01869 5 LLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELDGKTI--KLQIWDTAGQERFRTITSSYYR----GAHGI 78 (166) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEECCEEE--EEEEEECCCCHHHHHHHHHHCC----CCCEE T ss_conf 99982699548999998753800666576012356788999989589--9998626886011231121226----89889 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) +||+|++...++=. +..|++.+++.... .+|.+|||+|+|+ T Consensus 79 iivfdit~~~Sf~~-i~~w~~~i~~~~~~-------------------------------------~~~~ilVGNK~Dl- 119 (166) T cd01869 79 IIVYDVTDQESFNN-VKQWLQEIDRYASE-------------------------------------NVNKLLVGNKCDL- 119 (166) T ss_pred EEEEECCCHHHHHH-HHHHHHHHHHHCCC-------------------------------------CCEEEEEEECCCC- T ss_conf 99986798568999-99999999872599-------------------------------------8279998503333- Q ss_pred CCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHH Q ss_conf 58876678999999999998609468885120345678999888750 Q Ver_Hs_NP_0570 192 QDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLA 238 (351) Q Consensus 192 ~~~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r~r~~inhl~ 238 (351) .++|.+-..--+-+|-.+|+..+.+|-+.. ..+..+...++ T Consensus 120 ----~~~r~V~~~~~~~~a~~~~~~~~E~Sak~g--~~V~e~F~~la 160 (166) T cd01869 120 ----TDKRVVDYSEAQEFADELGIPFLETSAKNA--TNVEQAFMTMA 160 (166) T ss_pred ----CCCCCCCHHHHHHHHHHCCCCEEEEECCCC--CCHHHHHHHHH T ss_conf ----324557989999999965995999971489--88789999999 No 17 >cd04107 Rab32_Rab38 Rab38/Rab32 subfamily. Rab32 and Rab38 are members of the Rab family of small GTPases. Human Rab32 was first identified in platelets but it is expressed in a variety of cell types, where it functions as an A-kinase anchoring protein (AKAP). Rab38 has been shown to be melanocyte-specific. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site at the C-terminus, with sequence motifs CC, CXC, or CCX. Lipid binding is essential for membrane attachment, a key feature of most Rab proteins. Probab=99.44 E-value=7.9e-12 Score=98.01 Aligned_columns=181 Identities=18% Q ss_pred EEEEECCCCCHHHHHHHHCCC--CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 899865988637777755276--678887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDR--DEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r--~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |+++|+.+.||||||.||+.. .+.+.||++.||..-.-...++..= -.++|..+|--.+..|...-.+... .+ T Consensus 3 IvliGd~~VGKTsli~r~~~~~F~~~~~~Tig~d~~~k~i~~~~~~~v-~l~iwDtaGqe~f~~l~~~y~r~a~----~~ 77 (201) T cd04107 3 VLVIGDLGVGKTSIIKRYVHGIFSQHYKATIGVDFALKVIEWDPNTVV-RLQLWDIAGQERFGGMTRVYYRGAV----GA 77 (201) T ss_pred EEEEECCCCCHHHHHHHHHCCEECCCCCCEEEEEEEEEEEEECCCEEE-EEEEECCCCCHHHHHHHHHHCCCCC----EE T ss_conf 899816995489999997718006765650344677889987697689-9986227884245566565427987----69 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) +||.|++.+.++ +.+..|++.+++.+. .-..-++|++|||+|+|+ T Consensus 78 ilvyDit~~~SF-~~i~~W~~~i~~~~~---------------------------------~~~~~~ipiilVGNK~DL- 122 (201) T cd04107 78 IIVFDVTRPSTF-EAVLKWKADLDSKVT---------------------------------LPNGEPIPCLLLANKCDL- 122 (201) T ss_pred EEEEECCCHHHH-HHHHHHHHHHHHHHH---------------------------------CCCCCCCEEEEEECCCCC- T ss_conf 999873897789-999999999998740---------------------------------368997289997058873- Q ss_pred CCCCHHHHHHHHHHHHHHHHHCCCEEEE-EECHHHHHHH--HHHHHHHHHCCCCCCCEEEEECCCCEEEE Q ss_conf 5887667899999999999860946888-5120345678--99988875057777730575067757870 Q Ver_Hs_NP_0570 192 QDFESEKRKVICKTLRFVAHYYGASLMF-TSKSEALLLK--IRGVINQLAFGIDKSKSICVDQNKPLFIT 258 (351) Q Consensus 192 ~~~D~e~rK~i~r~LR~iAH~yGA~L~F-tSk~e~l~~r--~r~~inhl~FG~~~~k~~~~D~~kPl~I~ 258 (351) .+.|.+...-..-.|-.+|..-+| +|-....... |..++.+..=+....+...+..+.++... T Consensus 123 ----~~~~~v~~~e~~~~a~~~~~~~~fEtSAktg~nV~e~F~~l~~~i~~~~~~~~~~~~~~~~~~~~~ 188 (201) T cd04107 123 ----KKRLAKDGEQMDQFCKENGFIGWFETSAKEGINIEEAMRFLVKNILANDKNLQQAETPEDGSVIDL 188 (201) T ss_pred ----HHHCCCCHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC T ss_conf ----000447989999999963998268875048978789999999999974112466566656721132 No 18 >cd01866 Rab2 Rab2 subfamily. Rab2 is localized on cis-Golgi membranes and interacts with Golgi matrix proteins. Rab2 is also implicated in the maturation of vesicular tubular clusters (VTCs), which are microtubule-associated intermediates in transport between the ER and Golgi apparatus. In plants, Rab2 regulates vesicle trafficking between the ER and the Golgi bodies and is important to pollen tube growth. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site at the C-terminus, with sequence motifs CC, CXC, or CCX. Lipid binding is essential for membrane attachment, a key featur Probab=99.43 E-value=6.6e-12 Score=98.50 Aligned_columns=154 Identities=21% Q ss_pred EEEEECCCCCHHHHHHHHCCC--CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 899865988637777755276--678887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDR--DEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r--~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |+++|+.|.||||||.||+.. .+...||++.||.--.-...+... -.++|..+|.-.+..|...-+...+ .+ T Consensus 7 ivliGd~~VGKTsli~r~~~~~f~~~~~~Ti~~~~~~k~i~~~~~~v--~l~iwDt~G~e~~~~l~~~~~~~a~----~~ 80 (168) T cd01866 7 YIIIGDTGVGKSCLLLQFTDKRFQPVHDLTIGVEFGARMITIDGKQI--KLQIWDTAGQESFRSITRSYYRGAA----GA 80 (168) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEECCCCCCEE--EEEEEECCCCCCHHHHHHHHCCCCC----EE T ss_conf 99981698438999999854825754453000000123214678428--9998753888411245365347997----79 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) +||.|++.+.++ +.++.|++.++.+... .+|+++||+|.|+ T Consensus 81 iivfdvt~~~Sf-~~i~~w~~~~~~~~~~-------------------------------------~~piilVGnK~DL- 121 (168) T cd01866 81 LLVYDITRRETF-NHLTSWLEDARQHSNS-------------------------------------NMTIMLIGNKCDL- 121 (168) T ss_pred EEEEECCCHHHH-HHHHHHHHHHHHHCCC-------------------------------------CCEEEEEECCHHH- T ss_conf 999766997789-9999999999973699-------------------------------------9689998332012- Q ss_pred CCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHH Q ss_conf 58876678999999999998609468885120345678999888750 Q Ver_Hs_NP_0570 192 QDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLA 238 (351) Q Consensus 192 ~~~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r~r~~inhl~ 238 (351) ..+|.+.-.-.+.+|-.+|+..+-+|-+.. .++..+-.+++ T Consensus 122 ----~~~r~v~~~e~~~~a~~~~~~~~E~SAkt~--~nV~~~F~~la 162 (168) T cd01866 122 ----ESRREVSYEEGEAFAKEHGLIFMETSAKTA--SNVEEAFINTA 162 (168) T ss_pred ----HHHCCCCHHHHHHHHHHCCCEEEEEECCCC--CCHHHHHHHHH T ss_conf ----330477688999999965984999861579--88789999999 No 19 >cd04119 RJL RJL (RabJ-Like) subfamily. RJLs are found in many protists and as chimeras with C-terminal DNAJ domains in deuterostome metazoa. They are not found in plants, fungi, and protostome metazoa, suggesting a horizontal gene transfer between protists and deuterostome metazoa. RJLs lack any known membrane targeting signal and contain a degenerate phosphate/magnesium-binding 3 (PM3) motif, suggesting an impaired ability to hydrolyze GTP. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Probab=99.43 E-value=4.7e-12 Score=99.46 Aligned_columns=159 Identities=21% Q ss_pred EEEEECCCCCHHHHHHHHCCC--CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 899865988637777755276--678887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDR--DEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r--~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |++||+.+.|||||+.||++. .+.+.||++.+|..-.-...+... ..++|..+|.-.+..+....++.-+ .+ T Consensus 3 ivivGd~~vGKTsli~r~~~~~f~~~y~~Tig~~~~~k~i~~~~~~~--~l~iwDtaG~e~~~~~~~~~~~~a~----~~ 76 (168) T cd04119 3 VISMGNSGVGKSCIIKRYCEGRFVSKYLPTIGIDYGVKKVSVRNKEV--RVNFFDLSGHPEYLEVRNEFYKDTQ----GV 76 (168) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEECCEEE--EEEEEECCCCHHHHHHHHHHHCCCC----EE T ss_conf 89980798548999988771801665365035555567888879489--9998606898125788788723999----38 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) ++|.|+++++++=. +.+|++.++++... .-..-.+|+++||+|+|+ T Consensus 77 ilvydit~~~Sf~~-i~~w~~~~~~~~~~--------------------------------~~~~~~~~iilvGNK~Dl- 122 (168) T cd04119 77 LLVYDVTDRQSFEA-LDSWLKEMKQEGGP--------------------------------HGNMENIVVVVCANKIDL- 122 (168) T ss_pred EEEEECCCHHHHHH-HHHHHHHHHHHCCC--------------------------------CCCCCCCEEEEEECCCCC- T ss_conf 99985699778999-99999999986055--------------------------------566687479997053233- Q ss_pred CCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHH Q ss_conf 58876678999999999998609468885120345678999888750 Q Ver_Hs_NP_0570 192 QDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLA 238 (351) Q Consensus 192 ~~~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r~r~~inhl~ 238 (351) +++|.+-..--+-+|..+|+..+.+|-+.. ..+..+.+.++ T Consensus 123 ----~~~r~V~~~~~~~~a~~~~~~~~E~SAk~~--~nV~e~F~~l~ 163 (168) T cd04119 123 ----TKHRAVSEDEGRLWAESKGFKYFETSACTG--EGVNEMFQTLF 163 (168) T ss_pred ----CCCCCCCHHHHHHHHHHCCCEEEEEECCCC--CCHHHHHHHHH T ss_conf ----235767989999999964991999971589--78789999999 No 20 >cd01868 Rab11_like Rab11-like. Rab11a, Rab11b, and Rab25 are closely related, evolutionary conserved Rab proteins that are differentially expressed. Rab11a is ubiquitously synthesized, Rab11b is enriched in brain and heart and Rab25 is only found in epithelia. Rab11/25 proteins seem to regulate recycling pathways from endosomes to the plasma membrane and to the trans-Golgi network. Furthermore, Rab11a is thought to function in the histamine-induced fusion of tubulovesicles containing H+, K+ ATPase with the plasma membrane in gastric parietal cells and in insulin-stimulated insertion of GLUT4 in the plasma membrane of cardiomyocytes. Overexpression of Rab25 has recently been observed in ovarian cancer and breast cancer, and has been correlated with worsened outcomes in both diseases. In addition, Rab25 overexpression has also been observed in prostate cancer, transitional cell carcinoma of the bladder, and invasive breast tumor cells. GTPase activating proteins (GAPs) interact with GTP Probab=99.43 E-value=5.5e-12 Score=98.99 Aligned_columns=154 Identities=23% Q ss_pred EEEEECCCCCHHHHHHHHCCCC--CCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 8998659886377777552766--78887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDRD--EPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r~--e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |++||+.+.||||||.||+... +...||++.||. .+..--+..+=-.++|-.+|.-.+..+...-+...+ .+ T Consensus 6 i~~iG~~~VGKTsli~r~~~~~F~~~~~~Tig~~~~--~k~v~~~~~~~~l~iwDtaG~e~~~~~~~~~~~~a~----~~ 79 (165) T cd01868 6 IVLIGDSGVGKSNLLSRFTRNEFNLDSKSTIGVEFA--TRSIQIDGKTIKAQIWDTAGQERYRAITSAYYRGAV----GA 79 (165) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEE--EEEEEECCEEEEEEEECCCCCHHHHHHHHHHHCCCC----EE T ss_conf 999826996589999998638567455641001246--889864890899998538986124577676504886----79 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) ++|.|++.+.++ +.++.|++.++.+... .+|++|||+|.|+ T Consensus 80 iivyDit~~~Sf-~~i~~w~~~i~~~~~~-------------------------------------~~piilVGNK~DL- 120 (165) T cd01868 80 LLVYDITKKQTF-ENVERWLKELRDHADS-------------------------------------NIVIMLVGNKSDL- 120 (165) T ss_pred EEEEECCCHHHH-HHHHHHHHHHHHHCCC-------------------------------------CCEEEEEECCCCH- T ss_conf 999746997789-9999999999983289-------------------------------------9379998216562- Q ss_pred CCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHH Q ss_conf 58876678999999999998609468885120345678999888750 Q Ver_Hs_NP_0570 192 QDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLA 238 (351) Q Consensus 192 ~~~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r~r~~inhl~ 238 (351) .++|.+.-.-.+.+|-.+|+..+.+|-+.. ..+..+..+++ T Consensus 121 ----~~~r~v~~~e~~~~a~~~~~~~~e~Sak~g--~ni~~~F~~l~ 161 (165) T cd01868 121 ----RHLRAVPTEEAKAFAEKNGLSFIETSALDG--TNVEEAFKQLL 161 (165) T ss_pred ----HHCCCCCHHHHHHHHHHCCCCEEEEECCCC--CCHHHHHHHHH T ss_conf ----120377688999999965994999971479--88889999999 No 21 >cd04120 Rab12 Rab12 subfamily. Rab12 was first identified in canine cells, where it was localized to the Golgi complex. The specific function of Rab12 remains unknown, and inconsistent results about its cellular localization have been reported. More recent studies have identified Rab12 associated with post-Golgi vesicles, or with other small vesicle-like structures but not with the Golgi complex. Most Rab GTPases contain a lipid modification site at the C-terminus, with sequence motifs CC, CXC, or CCX. Lipid binding is essential for membrane attachment, a key feature of most Rab proteins. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic Probab=99.43 E-value=8.4e-12 Score=97.84 Aligned_columns=172 Identities=19% Q ss_pred EEEEECCCCCHHHHHHHHCCC--CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 899865988637777755276--678887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDR--DEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r--~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |+++|+.+.|||||++||.+. .+.+.||++.||.--.-.-.+... -.++|..+|--.+..|.+.-.+... .+ T Consensus 3 IvliGd~~VGKTsli~rf~~~~F~~~y~~Tig~df~~k~i~i~g~~i--~lqIwDTaGqE~f~~l~~~y~r~a~----g~ 76 (202) T cd04120 3 VIIIGSRGVGKTSLMRRFTDDTFCEACKSGVGVDFKIKTVELRGKKI--RLQIWDTAGQERFNSITSAYYRSAK----GI 76 (202) T ss_pred EEEECCCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEECCEEE--EEEEEECCCCCHHHHHHHHHHCCCC----EE T ss_conf 89980798428999999763811666565123578899999879189--9998756886035788777632898----79 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) +||.|++.+.++ +.+..|++.++++..+ .+|+++||+|.|+ T Consensus 77 ilVyDit~~~SF-~~l~~W~~~i~~~~~~-------------------------------------~~~iiLVGNK~DL- 117 (202) T cd04120 77 ILVYDITKKETF-DDLPKWMKMIDKYASE-------------------------------------DAELLLVGNKLDC- 117 (202) T ss_pred EEEEECCCHHHH-HHHHHHHHHHHHHCCC-------------------------------------CEEEEEEECCCCH- T ss_conf 999766984578-9999999999972499-------------------------------------3489997122212- Q ss_pred CCCCHHHHHHHHHHHHHHHHHCCCEEEE-EE------CHHHHHHHHHHHHHHHHCCCCCC-CEEEEECCCC Q ss_conf 5887667899999999999860946888-51------20345678999888750577777-3057506775 Q Ver_Hs_NP_0570 192 QDFESEKRKVICKTLRFVAHYYGASLMF-TS------KSEALLLKIRGVINQLAFGIDKS-KSICVDQNKP 254 (351) Q Consensus 192 ~~~D~e~rK~i~r~LR~iAH~yGA~L~F-tS------k~e~l~~r~r~~inhl~FG~~~~-k~~~~D~~kP 254 (351) ..+|.+-..--+-+|..+++..+| +| -.|.+..-+|.++.+........ ..-.++..+| T Consensus 118 ----~~~R~Vs~~e~~~~A~~~~~~~f~EtSAk~~~NV~e~F~~l~~~i~~~~~~~~~~~~~~~~~~~~~~ 184 (202) T cd04120 118 ----ETDREISRQQGEKFAQQITGMRFCEASAKDNFNVDEIFLKLVDDILKKMPLDILRNELSNSILSLQP 184 (202) T ss_pred ----HHHCCCCHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCC T ss_conf ----1020236799999999708970899851489888899999999999734310035666872110587 No 22 >cd04114 Rab30 Rab30 subfamily. Rab30 appears to be associated with the Golgi stack. It is expressed in a wide variety of tissue types and in humans maps to chromosome 11. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site at the C-terminus, with sequence motifs CC, CXC, or CCX. Lipid binding is essential for membrane attachment, a key feature of most Rab proteins. Due to the presence of truncated sequences in this CD, the lipid modification site is not available for annotation. Probab=99.42 E-value=5.7e-12 Score=98.91 Aligned_columns=154 Identities=18% Q ss_pred EEEEECCCCCHHHHHHHHCCC--CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 899865988637777755276--678887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDR--DEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r--~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |++||+.+.||||||.||+.. .+...||.+.+|.--...-++... -.++|..+|......|.....+... .+ T Consensus 10 ivliGd~~VGKTsli~rf~~~~f~~~~~~Ti~~~~~~k~~~~~~~~v--~l~iwDtaG~e~~~~~~~~~~~~a~----~~ 83 (169) T cd04114 10 IVLIGNAGVGKTCLVRRFTQGLFPPGQGATIGVDFMIKTVEIKGEKI--KLQIWDTAGQERFRSITQSYYRSAN----AL 83 (169) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEEECCEEE--EEEEEECCCCHHHHHHHHHHHCCCC----EE T ss_conf 99982698448999999862867854331122114788998889599--9999865898024677687604888----38 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) +||.|++.+.++ +.+..|++.++++... .+|++|||+|.|+ T Consensus 84 iivydit~~~Sf-~~i~~w~~~i~~~~~~-------------------------------------~~~iilVGNK~Dl- 124 (169) T cd04114 84 ILTYDITCEESF-RCLPEWLREIEQYANN-------------------------------------KVITILVGNKIDL- 124 (169) T ss_pred EEEEECCCHHHH-HHHHHHHHHHHHHHCC-------------------------------------CCEEEEEECCCCC- T ss_conf 999655984688-9999999999874069-------------------------------------9418998114321- Q ss_pred CCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHH Q ss_conf 58876678999999999998609468885120345678999888750 Q Ver_Hs_NP_0570 192 QDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLA 238 (351) Q Consensus 192 ~~~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r~r~~inhl~ 238 (351) .++|.+--.-.+-+|..+|...+-+|-+.. ..+..+..+++ T Consensus 125 ----~~~r~v~~~~~~~~a~~~~~~~~e~SAktg--~nV~~~F~~la 165 (169) T cd04114 125 ----AERREVSQQRAEEFSDAQDMYYLETSAKES--DNVEKLFLDLA 165 (169) T ss_pred ----CCCCCCCHHHHHHHHHHCCCEEEEEEECCC--CCHHHHHHHHH T ss_conf ----102365878999999964983999970379--88889999999 No 23 >cd04122 Rab14 Rab14 subfamily. Rab14 GTPases are localized to biosynthetic compartments, including the rough ER, the Golgi complex, and the trans-Golgi network, and to endosomal compartments, including early endosomal vacuoles and associated vesicles. Rab14 is believed to function in both the biosynthetic and recycling pathways between the Golgi and endosomal compartments. Rab14 has also been identified on GLUT4 vesicles, and has been suggested to help regulate GLUT4 translocation. In addition, Rab14 is believed to play a role in the regulation of phagocytosis. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GT Probab=99.42 E-value=6.9e-12 Score=98.37 Aligned_columns=153 Identities=17% Q ss_pred EEEEECCCCCHHHHHHHHCCC--CCCCCCCCCCCHHHHHHHCCCCCCCEEE-EEEEECCCCCHHHCEEEEECCCCCCEEE Q ss_conf 899865988637777755276--6788875310002211101578711178-8897157854202110000423512067 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDR--DEPPKPTLALEYTYGRRAKGHNTPKDIA-HFWELGGGTSLLDLISIPITGDTLRTFS 110 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r--~e~~KPTlALeYtygRra~~~~~~Kdva-H~WELGgg~~ls~Li~ipit~~~l~~~~ 110 (351) |+++|+.|.||||||.||++. .+...||++.+| ....-....+++- ++|..+|-..+..+...-++..+. T Consensus 5 ivviGd~~VGKTsli~r~~~~~f~~~~~~Ti~~~~---~~k~i~~~~~~v~l~i~Dt~G~e~~~~~~~~~~~~a~~---- 77 (166) T cd04122 5 YIIIGDMGVGKSCLLHQFTEKKFMADCPHTIGVEF---GTRIIEVNGQKIKLQIWDTAGQERFRAVTRSYYRGAAG---- 77 (166) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCEE---EEEEEEECCEEEEEEEEECCCCHHHHHHHHHHCCCCCE---- T ss_conf 99982699558999988763843644562102214---67888528908999986358860234553864269875---- Q ss_pred EEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECC Q ss_conf 78887369846899999999999999999999998526953789999999984146677600111068877997121000 Q Ver_Hs_NP_0570 111 LVLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDV 190 (351) Q Consensus 111 viivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~ 190 (351) ++||.|++.+.++ ..++.|++.++++... .+|+++||+|+|+ T Consensus 78 ~ilvydit~~~Sf-~~i~~w~~~~~~~~~~-------------------------------------~~~iilVGNK~DL 119 (166) T cd04122 78 ALMVYDITRRSTY-NHLSSWLTDARNLTNP-------------------------------------NTVIFLIGNKADL 119 (166) T ss_pred EEEEEECCCHHHH-HHHHHHHHHHHHCCCC-------------------------------------CCEEEEECCHHHH T ss_conf 9998207998789-9999999999740489-------------------------------------9579996372544 Q ss_pred CCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHH Q ss_conf 158876678999999999998609468885120345678999888750 Q Ver_Hs_NP_0570 191 FQDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLA 238 (351) Q Consensus 191 F~~~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r~r~~inhl~ 238 (351) .++|.+--.-..-+|..+|+..+.+|-++. .++..+-.+++ T Consensus 120 -----~~~r~v~~~e~~~~a~~~~~~~~E~SAk~~--~nV~e~F~~l~ 160 (166) T cd04122 120 -----EAQRDVTYEEAKQFADENGLLFLECSAKTG--ENVEDAFLETA 160 (166) T ss_pred -----HHHCCCCHHHHHHHHHHCCCEEEEEECCCC--CCHHHHHHHHH T ss_conf -----430354178999999964991999971589--88789999999 No 24 >cd04124 RabL2 RabL2 subfamily. RabL2 (Rab-like2) subfamily. RabL2s are novel Rab proteins identified recently which display features that are distinct from other Rabs, and have been termed Rab-like. RabL2 contains RabL2a and RabL2b, two very similar Rab proteins that share 98% sequence identity in humans. RabL2b maps to the subtelomeric region of chromosome 22q13.3 and RabL2a maps to 2q13, a region that suggests it is also a subtelomeric gene. Both genes are believed to be expressed ubiquitously, suggesting that RabL2s are the first example of duplicated genes in human proximal subtelomeric regions that are both expressed actively. Like other Rab-like proteins, RabL2s lack a prenylation site at the C-terminus. The specific functions of RabL2a and RabL2b remain unknown. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-b Probab=99.42 E-value=1.2e-11 Score=96.85 Aligned_columns=152 Identities=18% Q ss_pred EEEEECCCCCHHHHHHHHCCC--CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 899865988637777755276--678887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDR--DEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r--~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |.++|+.+.|||||++||+.. ++.+.||.++++ |-+....+...= ..++|..+|.-.+..+.+.-++..+ .+ T Consensus 3 iiliGd~~VGKTsli~r~~~~~f~~~~~~t~~~~~-~~k~~~~~~~~v-~l~iwDt~G~e~~~~~~~~~~~~a~----~~ 76 (161) T cd04124 3 IILLGDSAVGKSKLVERFLMDGYEPQQLSTYALTL-YKHNAKFEGKTI-LVDFWDTAGQERFQTMHASYYHKAH----AC 76 (161) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEE-EEEEEEECCEEE-EEEEEECCCCCHHHHHHHHHCCCCC----EE T ss_conf 89980699448898878653863766235325678-999999988699-9999745784110356674302478----58 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) +||.|++.+.++ +.+..|++.++++..+ +|+++||+|.|+ T Consensus 77 ilvfDit~~~Sf-~~l~~W~~~i~~~~~~--------------------------------------~p~ilVGNK~Dl- 116 (161) T cd04124 77 ILVFDVTRKITY-KNLSKWYEELREYRPE--------------------------------------IPCIVVANKIDL- 116 (161) T ss_pred EEEEECCCHHHH-HHHHHHHHHHHHHCCC--------------------------------------CEEEEEECCCCC- T ss_conf 999866996688-9999999999984699--------------------------------------379998237656- Q ss_pred CCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHH--HHHHHHHHH Q ss_conf 58876678999999999998609468885120345678--999888750 Q Ver_Hs_NP_0570 192 QDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLK--IRGVINQLA 238 (351) Q Consensus 192 ~~~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r--~r~~inhl~ 238 (351) +++ +..--+-+|..+++..+.+|-+...... +..++...+ T Consensus 117 ---~~~----~~~~~~~~a~~~~~~~fetSAk~g~nV~e~F~~~~~~~i 158 (161) T cd04124 117 ---DPS----VTQKKFNFAEKHNLPLYYVSAADGTNVVKLFQDAIKLAV 158 (161) T ss_pred ---CHH----HHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHH T ss_conf ---435----689999999965991999972689887899999999998 No 25 >cd04112 Rab26 Rab26 subfamily. First identified in rat pancreatic acinar cells, Rab26 is believed to play a role in recruiting mature granules to the plasma membrane upon beta-adrenergic stimulation. Rab26 belongs to the Rab functional group III, which are considered key regulators of intracellular vesicle transport during exocytosis. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site at the C-terminus, with sequence motifs CC, CXC, or CCX. Lipid binding is essential for membrane attachment, a key feature of most Rab proteins. Probab=99.42 E-value=5.1e-12 Score=99.21 Aligned_columns=154 Identities=21% Q ss_pred EEEEECCCCCHHHHHHHHCCC---CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEE Q ss_conf 899865988637777755276---67888753100022111015787111788897157854202110000423512067 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDR---DEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFS 110 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r---~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~ 110 (351) |++||+.+.||||||.||+.. .+.+.||++.+|..-.-...+... -.++|..+|.-.+..|...-++.-. . T Consensus 3 Iv~iGd~~VGKTsli~r~~~~~f~~~~~~~Tig~~~~~k~i~~~~~~i--~l~iwDtaGqe~~~~l~~~yy~~a~----~ 76 (191) T cd04112 3 VMLLGDSGVGKTCLLVRFKDGAFLNGNFIATVGIDFRNKVVTVDGVKV--KLQIWDTAGQERFRSVTHAYYRDAH----A 76 (191) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEEECCEEE--EEEEEECCCCHHHHHHHHHHHCCCC----E T ss_conf 899826995489999887628225876342111003677898879389--9998755887012455366613897----7 Q ss_pred EEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECC Q ss_conf 78887369846899999999999999999999998526953789999999984146677600111068877997121000 Q Ver_Hs_NP_0570 111 LVLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDV 190 (351) Q Consensus 111 viivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~ 190 (351) ++||.|++.+.+ ++.+..|++.++++..+ .+|++|||+|.|+ T Consensus 77 ~iivyDit~~~S-f~~i~~w~~~i~~~~~~-------------------------------------~~~ivlVGNK~DL 118 (191) T cd04112 77 LLLLYDITNKAS-FDNIRAWLTEIKEYAQE-------------------------------------DVVIMLLGNKADM 118 (191) T ss_pred EEEEEECCCHHH-HHHHHHHHHHHHHHCCC-------------------------------------CCEEEEEEECCCC T ss_conf 999987799789-99999999988852699-------------------------------------9489998632776 Q ss_pred CCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHH Q ss_conf 158876678999999999998609468885120345678999888750 Q Ver_Hs_NP_0570 191 FQDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLA 238 (351) Q Consensus 191 F~~~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r~r~~inhl~ 238 (351) .++|.+-..-.+.+|-.+|+..+.||-+++ ..+-.+...++ T Consensus 119 -----~~~r~V~~~e~~~~a~~~~~~~~EtSAk~~--~nI~e~F~~l~ 159 (191) T cd04112 119 -----SGERVVKREDGERLAKEYGVPFMETSAKTG--LNVELAFTAVA 159 (191) T ss_pred -----CCCCCCCHHHHHHHHHHCCCCEEEEECCCC--CCHHHHHHHHH T ss_conf -----322553889999999966995999962589--88889999999 No 26 >e1z2aa_ c.37.1.8 (A:) Rab23 {Mouse (Mus musculus) [TaxID:10090]} Probab=99.42 E-value=2.3e-12 Score=101.36 Aligned_columns=153 Identities=19% Q ss_pred EEEEECCCCCHHHHHHHHC--CCCCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 8998659886377777552--76678887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCL--DRDEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl--~r~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |+++|..|+|||||++|+. .-.+.+.||++.+|........+... ..++|..+|......+....+..-. .+ T Consensus 5 I~ivG~~~vGKSsli~~l~~~~~~~~~~~t~~~~~~~~~~~~~~~~~--~l~i~d~~~~~~~~~~~~~~~~~~d----~~ 78 (164) T e1z2aa_ 5 MVVVGNGAVGKSSMIQRYCKGIFTKDYKKTIGVDFLERQIQVNDEDV--RLMLWDTAGQEEFDAITKAYYRGAQ----AC 78 (164) T ss_pred EEEECCCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEEECCEEE--EEEECCCCCCCHHHHHHHHHCCCCC----EE T ss_conf 99982899889999999864801676234045335889999732888--7410146422024577886405875----79 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) ++|+|++++.++ +.+++|+..++.+..+ +|+++||+|+|.. T Consensus 79 i~v~d~~~~~s~-~~~~~~~~~i~~~~~~--------------------------------------~piiiv~nK~Dl~ 119 (164) T e1z2aa_ 79 VLVFSTTDRESF-EAISSWREKVVAEVGD--------------------------------------IPTALVQNKIDLL 119 (164) T ss_pred EEEEECCCCCCH-HHHHHHHHHHHHHCCC--------------------------------------CEEEEEEECCCCC T ss_conf 999740455424-6788888874310023--------------------------------------0023444200211 Q ss_pred CCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHH Q ss_conf 58876678999999999998609468885120345678999888750 Q Ver_Hs_NP_0570 192 QDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLA 238 (351) Q Consensus 192 ~~~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r~r~~inhl~ 238 (351) ++ +.+-..-++.+|..+|+..+.+|-... ..+..+..+++ T Consensus 120 ~~-----~~i~~~~~~~~~~~~~~~~~e~Sa~~~--~~i~~~f~~i~ 159 (164) T e1z2aa_ 120 DD-----SCIKNEEAEGLAKRLKLRFYRTSVKED--LNVSEVFKYLA 159 (164) T ss_pred CC-----CCCCHHHHHHHHHHCCCEEEEEECCCC--CCHHHHHHHHH T ss_conf 12-----367989999999965990999971589--88889999999 No 27 >1xtq_A GTP-binding protein RHEB; beta saddle, P-loop; HET: GDP; 2.00A {Homo sapiens} SCOP: c.37.1.8 Probab=99.41 E-value=1.5e-11 Score=96.26 Aligned_columns=154 Identities=17% Q ss_pred EEEEECCCCCHHHHHHHHCCCC--CCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 8998659886377777552766--78887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDRD--EPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r~--e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |+|+|..|+|||||++||+... +.+.||++.+| ++..--+...--.++|+.+|...+..+....+.... .+ T Consensus 9 i~iiG~~~vGKSsLi~~~~~~~~~~~~~~t~~~~~---~~~~~~~~~~~~l~i~D~~g~~~~~~~~~~~~~~~d----~~ 81 (177) T 1xtq_A 9 IAILGYRSVGKSSLTIQFVEGQFVDSYDPTIENTF---TKLITVNGQEYHLQLVDTAGQDEYSIFPQTYSIDIN----GY 81 (177) T ss_dssp EEEEESTTSSHHHHHHHHHHSCCCSCCCSSCCEEE---EEEEEETTEEEEEEEEECCCCCTTCCCCGGGTSSCC----EE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEE---EEEECCCCEEEEEEEEECCCCCCCCCCCCCCCHHHH----HH T ss_conf 89980799878999999862723666431232001---121013544566421001100011222332100033----32 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) ++|+|++.+.++ ..+..|+..+..+... ..+|+++||+|.|. T Consensus 82 i~v~d~~~~~s~-~~~~~~~~~i~~~~~~------------------------------------~~~piiivgnK~Dl- 123 (177) T 1xtq_A 82 ILVYSVTSIKSF-EVIKVIHGKLLDMVGK------------------------------------VQIPIMLVGNKKDL- 123 (177) T ss_dssp EEEEETTCHHHH-HHHHHHHHHHHHHHCS------------------------------------SCCCEEEEEECTTC- T ss_pred HHHHCCCCCCCC-CHHCCHHHHHHHHCCC------------------------------------CCCCEEEEEECCCC- T ss_conf 110001112320-0001001221110035------------------------------------78626999612573- Q ss_pred CCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHH Q ss_conf 58876678999999999998609468885120345678999888750 Q Ver_Hs_NP_0570 192 QDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLA 238 (351) Q Consensus 192 ~~~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r~r~~inhl~ 238 (351) ...+.+.-.-.+.+|-.+|+..+.+|-... ..+..+.+.++ T Consensus 124 ----~~~~~v~~~~~~~~~~~~~~~~~e~Sa~~g--~gi~elf~~ii 164 (177) T 1xtq_A 124 ----HMERVISYEEGKALAESWNAAFLESSAKEN--QTAVDVFRRII 164 (177) T ss_dssp ----GGGCCSCHHHHHHHHHHHTCEEEECCTTCH--HHHHHHHHHHH T ss_pred ----HHHCCCCHHHHHHHHHHCCCEEEEEECCCC--CCHHHHHHHHH T ss_conf ----000157888999999964982899861689--78889999999 No 28 >cd04125 RabA_like RabA-like subfamily. RabA was first identified in D. discoideum, where its expression levels were compared to other Rabs in growing and developing cells. The RabA mRNA levels were below the level of detection by Northern blot analysis, suggesting a very low level of expression. The function of RabA remains unknown. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site at the C-terminus, with sequence motifs CC, CXC, or CCX. Lipid binding is essential for membrane attachment, a key feature of most Rab proteins. Probab=99.41 E-value=6.1e-12 Score=98.72 Aligned_columns=154 Identities=18% Q ss_pred EEEEECCCCCHHHHHHHHCCC--CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 899865988637777755276--678887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDR--DEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r--~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |++||+.+.||||||.||+.. .+.+.||++.||..-.-...+... -.++|..+|...+..|...-+.. .-.+ T Consensus 3 IvviGd~~VGKTsli~r~~~~~f~~~~~~Tig~d~~~k~i~~~~~~v--~l~iwDtaGqe~~~~l~~~~~~~----a~~~ 76 (188) T cd04125 3 VVIIGDYGVGKSSLLKRFTEDEFSESTKSTIGVDFKIKTVYIENKII--KLQIWDTNGQERFRSLNNSYYRG----AHGY 76 (188) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEECCEEE--EEEEEECCCCCHHHHHHHHHHCC----CCEE T ss_conf 89982699548999998762801776467302125788999868499--99987569982025676876308----9859 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) +||.|++.+.++ +.++.|+..+++...+ .+|++|||+|+|+. T Consensus 77 ilvyDit~~~Sf-~~i~~w~~~i~~~~~~-------------------------------------~~~~ilvgNK~DL~ 118 (188) T cd04125 77 LLVYDVTDQESF-ENLKFWINEINRYARE-------------------------------------NVIKVIVANKSDLV 118 (188) T ss_pred EEEEECCCHHHH-HHHHHHHHHHHHHCCC-------------------------------------CCEEEEEEECCCCH T ss_conf 999866997899-9999999999861699-------------------------------------96899985135230 Q ss_pred CCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHH Q ss_conf 58876678999999999998609468885120345678999888750 Q Ver_Hs_NP_0570 192 QDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLA 238 (351) Q Consensus 192 ~~~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r~r~~inhl~ 238 (351) +.|.+--.-.+.+|..+|+..+.+|-... ..+..+...++ T Consensus 119 -----~~r~V~~~~~~~~a~~~~~~~fEtSAktg--~nV~e~F~~l~ 158 (188) T cd04125 119 -----NNKVVDSNIAKSFCDSLNIPFFETSAKQS--INVEEAFILLV 158 (188) T ss_pred -----HHCCCCHHHHHHHHHHCCCCEEEEECCCC--CCHHHHHHHHH T ss_conf -----12336999999999856992999962589--88889999999 No 29 >cd01861 Rab6 Rab6 subfamily. Rab6 is involved in microtubule-dependent transport pathways through the Golgi and from endosomes to the Golgi. Rab6A of mammals is implicated in retrograde transport through the Golgi stack, and is also required for a slow, COPI-independent, retrograde transport pathway from the Golgi to the endoplasmic reticulum (ER). This pathway may allow Golgi residents to be recycled through the ER for scrutiny by ER quality-control systems. Yeast Ypt6p, the homolog of the mammalian Rab6 GTPase, is not essential for cell viability. Ypt6p acts in endosome-to-Golgi, in intra-Golgi retrograde transport, and possibly also in Golgi-to-ER trafficking. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Probab=99.41 E-value=5e-12 Score=99.29 Aligned_columns=154 Identities=23% Q ss_pred EEEEECCCCCHHHHHHHHCCC--CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 899865988637777755276--678887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDR--DEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r--~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |++||+.|.||||||.||+.. .+.+.||++.+|.--.....+... -..+|..+|.-.+..|...-++..+ .+ T Consensus 3 I~~iG~~~vGKTsli~r~~~~~f~~~~~~Tig~~~~~k~i~~~~~~v--~l~i~Dt~G~e~~~~l~~~~~~~~~----~~ 76 (161) T cd01861 3 LVFLGDQSVGKTSIITRFMYDTFDNQYQATIGIDFLSKTMYLEDKTV--RLQLWDTAGQERFRSLIPSYIRDSS----VA 76 (161) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEEECCEEE--EEEEECCCCCHHHHHHHHHHCCCCC----CE T ss_conf 89981798558999998863812665574343368888998879399--9998517884257788898603888----17 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) ++|.|++.+.++ +.+..|++.+++.... .+|++|||+|+|+ T Consensus 77 ilvyd~t~~~Sf-~~~~~w~~~i~~~~~~-------------------------------------~~~iilVgNK~Dl- 117 (161) T cd01861 77 VVVYDITNRQSF-DNTDKWIDDVRDERGN-------------------------------------DVIIVLVGNKTDL- 117 (161) T ss_pred EEEEECCCHHHH-HHHHHHHHHHHHHCCC-------------------------------------CCEEEEEECCCCH- T ss_conf 999853987689-9999999888862399-------------------------------------9789997155332- Q ss_pred CCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHH Q ss_conf 58876678999999999998609468885120345678999888750 Q Ver_Hs_NP_0570 192 QDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLA 238 (351) Q Consensus 192 ~~~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r~r~~inhl~ 238 (351) .++|.+--.-.+.+|-.+|+..+-+|-+.. ..+..+...++ T Consensus 118 ----~~~~~v~~~~~~~~a~~~~~~~~E~Sak~~--~nV~e~F~~ia 158 (161) T cd01861 118 ----SDKRQVSTEEGEKKAKELNAMFIETSAKAG--HNVKELFRKIA 158 (161) T ss_pred ----HHCCCCCHHHHHHHHHHCCCCEEEEECCCC--CCHHHHHHHHH T ss_conf ----121367688999999965993999971489--78789999999 No 30 >cd04117 Rab15 Rab15 subfamily. Rab15 colocalizes with the transferrin receptor in early endosome compartments, but not with late endosomal markers. It codistributes with Rab4 and Rab5 on early/sorting endosomes, and with Rab11 on pericentriolar recycling endosomes. It is believed to function as an inhibitory GTPase that regulates distinct steps in early endocytic trafficking. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site at the C-terminus, with sequence motifs CC, CXC, or CCX. Lipid binding is essential for membrane attachment, a key feature of most Rab proteins. Due to Probab=99.41 E-value=1.4e-11 Score=96.36 Aligned_columns=154 Identities=21% Q ss_pred EEEEECCCCCHHHHHHHHCCC--CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 899865988637777755276--678887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDR--DEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r--~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |+++|+.+.|||||+.||++. .+.+.||++.||..-.-...+... -.++|..+|.-.+..|.+......+ .+ T Consensus 3 IiliGd~~VGKTsli~rf~~~~F~~~~~~Tig~~~~~k~i~~~~~~i--~l~iwDtaG~e~~~~l~~~~~~~a~----~~ 76 (161) T cd04117 3 LLLIGDSGVGKTCLLCRFTDNEFHSSHISTIGVDFKMKTIEVDGIKV--RIQIWDTAGQERYQTITKQYYRRAQ----GI 76 (161) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEECCEEE--EEEEEECCCCHHHHHHHHHHCCCCC----EE T ss_conf 89982698448999998754821754344221114678998989699--9998746987235667686446998----89 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) +||.|++++.++ +.+..|++.+++...+ .+|+++||+|.| T Consensus 77 ilvydit~~~Sf-~~i~~w~~~i~~~~~~-------------------------------------~~~~ilVgnK~D-- 116 (161) T cd04117 77 FLVYDISSERSY-QHIMKWVSDVDEYAPE-------------------------------------GVQKILIGNKAD-- 116 (161) T ss_pred EEEEECCCHHHH-HHHHHHHHHHHHHCCC-------------------------------------CCEEEEEECCCC-- T ss_conf 999865997899-9999999999972579-------------------------------------946999811578-- Q ss_pred CCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHH Q ss_conf 58876678999999999998609468885120345678999888750 Q Ver_Hs_NP_0570 192 QDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLA 238 (351) Q Consensus 192 ~~~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r~r~~inhl~ 238 (351) ..++|.+...-.+.+|-.+|+..+.+|-+.+ ..+..+..+++ T Consensus 117 ---l~~~r~v~~~e~~~~a~~~~~~~~E~SAk~~--~nV~e~F~~la 158 (161) T cd04117 117 ---EEQKRQVGDEQGNKLAKEYGMDFFETSACTN--SNIKESFTRLT 158 (161) T ss_pred ---HHHHHHHHHHHHHHHHHHCCCCEEEEECCCC--CCHHHHHHHHH T ss_conf ---0231114689999999965996999971589--88789999999 No 31 >pfam00071 Ras Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices. Probab=99.41 E-value=7.2e-12 Score=98.26 Aligned_columns=154 Identities=23% Q ss_pred EEEEECCCCCHHHHHHHHCCC--CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 899865988637777755276--678887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDR--DEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r--~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |++||+.|+||||||.|++.. .+...||++.++.--.-.-.+... -..+|..+|......+....+.. .-++ T Consensus 2 i~viG~~~vGKTsli~r~~~~~f~~~~~~Ti~~~~~~k~v~~~~~~~--~l~i~Dt~g~e~~~~~~~~~~~~----ad~~ 75 (162) T pfam00071 2 LVLVGDGGVGKSSLLIRFTQNKFPEEYIPTIGVDFYTKTIEVDGKTV--KLQIWDTAGQERFRSLRPAYYRG----AQGF 75 (162) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEEECCEEE--EEEEEECCCCCHHHHHHHHHCCC----CCEE T ss_conf 78881799668999999863832765442010157899998736799--99998669980135675865048----9889 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) ++|+|++...++ +.++.|++.+++...+ ++|++|||+|.|+ T Consensus 76 ilvfd~~~~~Sf-~~i~~w~~~i~~~~~~-------------------------------------~~piilvgnK~Dl- 116 (162) T pfam00071 76 LLVYDITSRDSF-ENVKKWLEEILRHADE-------------------------------------NVPIVLVGNKCDL- 116 (162) T ss_pred EEEEECCCHHHH-HHHHHHHHHHHHHCCC-------------------------------------CCEEEEEEECCHH- T ss_conf 999877997899-9999999999984599-------------------------------------9489998504201- Q ss_pred CCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHH Q ss_conf 58876678999999999998609468885120345678999888750 Q Ver_Hs_NP_0570 192 QDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLA 238 (351) Q Consensus 192 ~~~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r~r~~inhl~ 238 (351) +++|.+...-.+-+|-.+++..+.+|-+.. ..+..+...++ T Consensus 117 ----~~~~~i~~~e~~~~~~~~~~~y~e~Sak~g--~gI~e~F~~l~ 157 (162) T pfam00071 117 ----EDQRVVSTEEGEALAKELGLPFMETSAKTN--TNVEEAFEELA 157 (162) T ss_pred ----HHHCCCCHHHHHHHHHHCCCCEEEEECCCC--CCHHHHHHHHH T ss_conf ----121167688999999964995999971479--88889999999 No 32 >e1xtqa1 c.37.1.8 (A:3-169) GTP-binding protein RheB {Human (Homo sapiens) [TaxID:9606]} SCOP: u1xtsa_ u1xtra_ Probab=99.41 E-value=1e-11 Score=97.27 Aligned_columns=161 Identities=18% Q ss_pred HCCCCEEEEEECCCCCHHHHHHHHCCC--CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCC Q ss_conf 125745899865988637777755276--678887531000221110157871117888971578542021100004235 Q Ver_Hs_NP_0570 28 EIAEKFVFFIGSKNGGKTTIILRCLDR--DEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDT 105 (351) Q Consensus 28 ~~~ek~v~~vGsk~~GKTTli~Rfl~r--~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~ 105 (351) |.-..-|++||+.|+||||||+||+.. .+.+.||++.+|+.-...++..- ..++|+.+|......+....+.. T Consensus 1 ~~k~~Ki~ivG~~~vGKTsLi~~~~~~~~~~~~~~t~~~~~~~~~~~~~~~~---~l~~~d~~g~~~~~~~~~~~~~~-- 75 (167) T e1xtqa1 1 QSKSRKIAILGYRSVGKSSLTIQFVEGQFVDSYDPTIENTFTKLITVNGQEY---HLQLVDTAGQDEYSIFPQTYSID-- 75 (167) T ss_pred CCCCEEEEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEECCEEE---EEEEEEECCCCCCCCCCCCCCCC-- T ss_conf 9874178998169987999999986381167734405531079999824899---99998503623343455111454-- Q ss_pred CCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEC Q ss_conf 12067788873698468999999999999999999999985269537899999999841466776001110688779971 Q Ver_Hs_NP_0570 106 LRTFSLVLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIG 185 (351) Q Consensus 106 l~~~~viivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg 185 (351) .-.+++|+|++.+.++ +.+..|+..+..+..+ ..+|++||| T Consensus 76 --~d~~ilv~d~~~~~sf-~~~~~~~~~i~~~~~~------------------------------------~~~piiivg 116 (167) T e1xtqa1 76 --INGYILVYSVTSIKSF-EVIKVIHGKLLDMVGK------------------------------------VQIPIMLVG 116 (167) T ss_pred --CEEEEEEEEECCCCCH-HHHHHHHHHHHHHHCC------------------------------------CCCCEEEEE T ss_conf --0279998641232102-3567777899864125------------------------------------786189986 Q ss_pred CEECCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHH--HHHHHHHH Q ss_conf 21000158876678999999999998609468885120345678--99988875 Q Ver_Hs_NP_0570 186 SKYDVFQDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLK--IRGVINQL 237 (351) Q Consensus 186 ~KYD~F~~~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r--~r~~inhl 237 (351) +|.|. .+.|.+--.-.+.+|..+|+..+.+|-....... ++.+|... T Consensus 117 nK~Dl-----~~~~~v~~~~~~~~~~~~~~~~~e~Sak~~~~v~e~f~~li~~~ 165 (167) T e1xtqa1 117 NKKDL-----HMERVISYEEGKALAESWNAAFLESSAKENQTAVDVFRRIILEA 165 (167) T ss_pred ECCCC-----CCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHH T ss_conf 13464-----22246898999999995598299997158977789999999998 No 33 >cd04118 Rab24 Rab24 subfamily. Rab24 is distinct from other Rabs in several ways. It exists primarily in the GTP-bound state, having a low intrinsic GTPase activity; it is not efficiently geranyl-geranylated at the C-terminus; it does not form a detectable complex with Rab GDP-dissociation inhibitors (GDIs); and it has recently been shown to undergo tyrosine phosphorylation when overexpressed in vitro. The specific function of Rab24 still remains unknown. It is found in a transport route between ER-cis-Golgi and late endocytic compartments. It is putatively involved in an autophagic pathway, possibly directing misfolded proteins in the ER to degradative pathways. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilita Probab=99.40 E-value=3.9e-12 Score=99.97 Aligned_columns=157 Identities=18% Q ss_pred EEEEECCCCCHHHHHHHHCCC---CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEE Q ss_conf 899865988637777755276---67888753100022111015787111788897157854202110000423512067 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDR---DEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFS 110 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r---~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~ 110 (351) |++||+.+.|||||++||+.. ++.+.||++.+|.--+-..++... ..++|..+|--.+..|...-.+..+ . T Consensus 3 vvliGd~~VGKTsli~r~~~~~F~~~~y~~Tig~~f~~k~i~~~~~~v--~l~iwDtaGqe~~~~l~~~~yr~a~----~ 76 (193) T cd04118 3 VVMLGKESVGKTSLVERYVHHRFLVGPYQNTIGAAFVAKRMVVGERVV--TLGIWDTAGSERYEAMSRIYYRGAK----A 76 (193) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEECCCEEE--EEEEECCCCCHHHHHHHHHHHCCCC----E T ss_conf 899807983289998887527316887466133235888864387579--9998638875357898987612887----3 Q ss_pred EEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECC Q ss_conf 78887369846899999999999999999999998526953789999999984146677600111068877997121000 Q Ver_Hs_NP_0570 111 LVLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDV 190 (351) Q Consensus 111 viivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~ 190 (351) ++||.|++++.++ +.++.|++.+++..+. +|++|||+|.|+ T Consensus 77 ~ilvydit~~~SF-~~l~~w~~~i~~~~~~--------------------------------------~~iilVGNK~DL 117 (193) T cd04118 77 AIVCYDLTDSSSF-ERAKFWVKELQNLEEH--------------------------------------CKIYLCGTKSDL 117 (193) T ss_pred EEEEEECCCCHHH-HHHHHHHHHHHHCCCC--------------------------------------CEEEEEECCCCH T ss_conf 8999874881017-8999999998621899--------------------------------------789998414221 Q ss_pred CCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHH Q ss_conf 158876678999999999998609468885120345678999888750 Q Ver_Hs_NP_0570 191 FQDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLA 238 (351) Q Consensus 191 F~~~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r~r~~inhl~ 238 (351) -+. +...|.+--.-.+-+|-.+|+..+.+|-+.. ..+..+-..++ T Consensus 118 ~~~-~~~~r~V~~ee~~~~A~~~~~~~fEtSAktg--~nV~elF~~ia 162 (193) T cd04118 118 IEQ-DRSLRQVDFHDVQDFADEIKAQHFETSSKTG--QNVDELFQKVA 162 (193) T ss_pred HHC-CCCCCCCCHHHHHHHHHHCCCCEEEEECCCC--CCHHHHHHHHH T ss_conf 120-6664446889999999966995999962589--88889999999 No 34 >cd01864 Rab19 Rab19 subfamily. Rab19 proteins are associated with Golgi stacks. Similarity analysis indicated that Rab41 is closely related to Rab19. However, the function of these Rabs is not yet chracterized. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site at the C-terminus, with sequence motifs CC, CXC, or CCX. Lipid binding is essential for membrane attachment, a key feature of most Rab proteins. Due to the presence of truncated sequences in this CD, the lipid modification site is not available for annotation. Probab=99.40 E-value=7.7e-12 Score=98.08 Aligned_columns=154 Identities=19% Q ss_pred EEEEECCCCCHHHHHHHHCCC--CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 899865988637777755276--678887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDR--DEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r--~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |++||+.+.||||||.||+.. .+.+.||.+.+|+.-...-.+... ...+|..+|...+..|...-++.-. .+ T Consensus 6 ivivGd~~vGKTsli~rf~~~~F~~~~~~tig~~~~~k~i~~~~~~v--~l~iwDt~G~e~~~~l~~~~~~~~~----~~ 79 (165) T cd01864 6 IILIGDSNVGKTCVVQRFKSGTFSERQGNTIGVDFTMKTLEIEGKRV--KLQIWDTAGQERFRTITQSYYRSAN----GA 79 (165) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEECCEEE--EEEEEECCCCCHHHHHHHHHCCCCC----EE T ss_conf 99980799448999998762820776677112577899999889589--9999754887013577686426998----79 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) +||.|++.+.++=. +..|+..++.+... .+|+++||+|.|+ T Consensus 80 ilvydit~~~Sf~~-l~~w~~~i~~~~~~-------------------------------------~~~ivlVGNK~Dl- 120 (165) T cd01864 80 IIAYDITRRSSFES-VPHWIEEVEKYGAS-------------------------------------NVVLLLIGNKCDL- 120 (165) T ss_pred EEEEECCCHHHHHH-HHHHHHHHHHCCCC-------------------------------------CCEEEEEECCCCC- T ss_conf 99987599779999-99988889851698-------------------------------------9579997242110- Q ss_pred CCCCHHHHHHHHHHHHHHHHHCCCEEEE-EECHHHHHHHHHHHHHHHH Q ss_conf 5887667899999999999860946888-5120345678999888750 Q Ver_Hs_NP_0570 192 QDFESEKRKVICKTLRFVAHYYGASLMF-TSKSEALLLKIRGVINQLA 238 (351) Q Consensus 192 ~~~D~e~rK~i~r~LR~iAH~yGA~L~F-tSk~e~l~~r~r~~inhl~ 238 (351) .++|.+.-.-.+-+|..+|+.-+| +|-++. ..+..+-.+++ T Consensus 121 ----~~~r~V~~~~~~~~a~~~~~~~~~E~SAk~~--~nv~e~F~~la 162 (165) T cd01864 121 ----EEQREVLFEEACTLAEKNGMLAVLETSAKES--QNVEEAFLLMA 162 (165) T ss_pred ----CCCCCCCHHHHHHHHHHCCCCEEEEEEECCC--CCHHHHHHHHH T ss_conf ----0035545789999999649948999740489--89889999999 No 35 >1vg8_A RAS-related protein RAB-7; GTP-binding protein; HET: GNP; 1.70A {Rattus norvegicus} SCOP: c.37.1.8 Probab=99.40 E-value=2.9e-11 Score=94.44 Aligned_columns=158 Identities=20% Q ss_pred EEEEECCCCCHHHHHHHHCCCC--CCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 8998659886377777552766--78887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDRD--EPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r~--e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |+++|..|+|||||++|+.... +.+.||++.+|.-......+... ..++|+.+|-..+..+.. ...-..-.+ T Consensus 11 I~iiG~~~vGKSsLi~~l~~~~~~~~~~~ti~~~~~~~~~~~~~~~~--~~~i~D~~g~~~~~~~~~----~~~~~~~~~ 84 (207) T 1vg8_A 11 VIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVDDRLV--TMQIWDTAGQERFQSLGV----AFYRGADCC 84 (207) T ss_dssp EEEECCTTSSHHHHHHHHHHSCCCSSCCCCCSEEEEEEEEESSSCEE--EEEEEEECSSGGGSCSCC----GGGTTCSEE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEECCCEE--EEEEECCCCCCCCCCCCC----CCCCCCCEE T ss_conf 99980799878999999864801675256303578999975127615--556532776431122553----100242113 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) ++|+|.+.+. -+++++.|+..++.... ...+..+|++|||+|+|.. T Consensus 85 i~v~d~~~~~-s~~~~~~~~~~~~~~~~---------------------------------~~~~~~~piiiV~nK~Dl~ 130 (207) T 1vg8_A 85 VLVFDVTAPN-TFKTLDSWRDEFLIQAS---------------------------------PRDPENFPFVVLGNKIDLE 130 (207) T ss_dssp EEEEETTCHH-HHHTHHHHHHHHHHHHC---------------------------------CSSGGGSCEEEEEECTTSS T ss_pred EEEEEEECCH-HHCCCHHHHHHHHHHHH---------------------------------HCCCCCCEEEEEECCCCCC T ss_conf 3444320000-10020346899999862---------------------------------1167884189984464510 Q ss_pred CCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHH Q ss_conf 58876678999999999998609468885120345678999888750 Q Ver_Hs_NP_0570 192 QDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLA 238 (351) Q Consensus 192 ~~~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r~r~~inhl~ 238 (351) ..-.+.. +..++++..+++..+++|-... ..+..+++.++ T Consensus 131 ~~~~~~~-----~~~~~~~~~~~~~~~~~Sa~~~--~gi~~lf~~l~ 170 (207) T 1vg8_A 131 NRQVATK-----RAQAWCYSKNNIPYFETSAKEA--INVEQAFQTIA 170 (207) T ss_dssp CCCSCHH-----HHHHHHHHTTSCCEEECBTTTT--BSHHHHHHHHH T ss_pred HHHHHHH-----HHHHHHHHHCCCCEEEEECCCC--CCHHHHHHHHH T ss_conf 1110489-----9999999853894477513567--78889999999 No 36 >cd04175 Rap1 Rap1 subgroup. The Rap1 subgroup is part of the Rap subfamily of the Ras family. It can be further divided into the Rap1a and Rap1b isoforms. In humans, Rap1a and Rap1b share 95% sequence homology, but are products of two different genes located on chromosomes 1 and 12, respectively. Rap1a is sometimes called smg p21 or Krev1 in the older literature. Rap1 proteins are believed to perform different cellular functions, depending on the isoform, its subcellular localization, and the effector proteins it binds. For example, in rat salivary gland, neutrophils, and platelets, Rap1 localizes to secretory granules and is believed to regulate exocytosis or the formation of secretory granules. Rap1 has also been shown to localize in the Golgi of rat fibroblasts, zymogen granules, plasma membrane, and the microsomal membrane of pancreatic acini, as well as in the endocytic compartment of skeletal muscle cells and fibroblasts. High expression of Rap1 has been observed in the n Probab=99.40 E-value=1.7e-11 Score=95.93 Aligned_columns=154 Identities=20% Q ss_pred EEEEECCCCCHHHHHHHHCCC--CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 899865988637777755276--678887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDR--DEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r--~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |++||+.+.||||||.||+.. .+.+.||++-.| ++.---...+-...+|..+|.-.+..+.+.-.+. .-.+ T Consensus 4 ivlvGd~~VGKTsli~r~~~~~f~~~y~~Ti~~~~---~k~i~~~~~~~~l~iwDtaG~e~~~~~~~~~~~~----a~~~ 76 (164) T cd04175 4 LVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSY---RKQVEVDGQQCMLEILDTAGTEQFTAMRDLYMKN----GQGF 76 (164) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCEE---EEEEEECCEEEEEEEEECCCCCHHHHHHHHHCCC----CCEE T ss_conf 89980798538999999862800665575312136---8999888948999987279982023576755058----9879 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) +||.|++.+.++ +.+..|+..+.+..+ .-.+|+++||+|.|+ T Consensus 77 ilvydit~~~Sf-~~i~~~~~~i~~~~~------------------------------------~~~ip~vlvGNK~DL- 118 (164) T cd04175 77 VLVYSITAQSTF-NDLQDLREQILRVKD------------------------------------TEDVPMILVGNKCDL- 118 (164) T ss_pred EEEEECCCHHHH-HHHHHHHHHHHHHCC------------------------------------CCCCEEEEEECCCCC- T ss_conf 999866997788-999999888886408------------------------------------998579998125653- Q ss_pred CCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHH Q ss_conf 58876678999999999998609468885120345678999888750 Q Ver_Hs_NP_0570 192 QDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLA 238 (351) Q Consensus 192 ~~~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r~r~~inhl~ 238 (351) .+.|.+--.-...+|..+|+..+-+|-+.+ ..+..+...++ T Consensus 119 ----~~~r~V~~~~~~~~a~~~~~~~~E~Sak~~--~nV~e~F~~l~ 159 (164) T cd04175 119 ----EDERVVGKEQGQNLARQWGCAFLETSAKAK--INVNEIFYDLV 159 (164) T ss_pred ----CCCCCCCHHHHHHHHHHCCCCEEEEECCCC--CCHHHHHHHHH T ss_conf ----000334078999999965993899971479--88789999999 No 37 >cd00157 Rho Rho (Ras homology) family. Members of the Rho family include RhoA, Cdc42, Rac, Rnd, Wrch1, RhoBTB, and Rop. There are 22 human Rho family members identified currently. These proteins are all involved in the reorganization of the actin cytoskeleton in response to external stimuli. They also have roles in cell transformation by Ras in cytokinesis, in focal adhesion formation and in the stimulation of stress-activated kinase. These various functions are controlled through distinct effector proteins and mediated through a GTP-binding/GTPase cycle involving three classes of regulating proteins: GAPs (GTPase-activating proteins), GEFs (guanine nucleotide exchange factors), and GDIs (guanine nucleotide dissociation inhibitors). Most Rho proteins contain a lipid modification site at the C-terminus, with a typical sequence motif CaaX, where a = an aliphatic amino acid and X = any amino acid. Lipid binding is essential for membrane attachment, a key feature of most Rho protein Probab=99.39 E-value=8.9e-12 Score=97.67 Aligned_columns=158 Identities=18% Q ss_pred EEEEECCCCCHHHHHHHHCCC--CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 899865988637777755276--678887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDR--DEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r--~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |+++|+.+.|||||+.||... .+.+.||+.-.| ++.-......--.++|..+|...+..|...-++.-+. + T Consensus 3 i~liGd~~VGKTsli~r~~~~~f~~~~~~Ti~~~~---~~~i~~~~~~~~l~iwDt~G~e~~~~l~~~~~~~a~~----~ 75 (171) T cd00157 3 IVVVGDGAVGKTCLLISYTTGKFPTEYVPTVFDNY---SATVTVDGKQVNLGLWDTAGQEEYDRLRPLSYPNTDV----F 75 (171) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEE---EEEEEECCEEEEEEEEECCCCHHHHHHHHHHHCCCCE----E T ss_conf 89980799548999999863831665343265214---5578755679999996067743467898987328985----8 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) +||.|++.+.++=.-.++|++.++..... +|++|||+|.|+- T Consensus 76 ilvydit~~~Sf~~~~~~w~~~i~~~~~~--------------------------------------~piilVgnK~DL~ 117 (171) T cd00157 76 LICFSVDSPSSFENVKTKWIPEIRHYCPN--------------------------------------VPIILVGTKIDLR 117 (171) T ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHCCC--------------------------------------CEEEEEECCCCCC T ss_conf 99971688658999999989999984689--------------------------------------5699985374421 Q ss_pred CCCC------HHHHHHHHHHHHHHHHHCCCEEEE-EECHHHHHHHHHHHHHHHH Q ss_conf 5887------667899999999999860946888-5120345678999888750 Q Ver_Hs_NP_0570 192 QDFE------SEKRKVICKTLRFVAHYYGASLMF-TSKSEALLLKIRGVINQLA 238 (351) Q Consensus 192 ~~~D------~e~rK~i~r~LR~iAH~yGA~L~F-tSk~e~l~~r~r~~inhl~ 238 (351) .+.. ..+|.+--.-.+-+|-.+|+..+| +|-+.. .++..+...++ T Consensus 118 ~~~~~~~~~~~~~r~Vs~~e~~~~a~~~~~~~f~EtSAktg--~nV~e~F~~l~ 169 (171) T cd00157 118 DDENTLKKLEKGKEPITPEEGEKLAKEIGAIGYMECSALTQ--EGVKEVFEEAI 169 (171) T ss_pred CCHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEECCCC--CCHHHHHHHHH T ss_conf 21122322101357789899999999739952788750489--88789999996 No 38 >d1wmsa_ c.37.1.8 (A:) Rab9a {Human (Homo sapiens)} Probab=99.39 E-value=2.4e-11 Score=94.93 Aligned_columns=157 Identities=19% Q ss_pred EEEEECCCCCHHHHHHHHCCC--CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 899865988637777755276--678887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDR--DEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r--~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |+++|..|+||||||+||... .+.+.||++.+|..-.-...+... ..++|+.+|......+....+..-. .+ T Consensus 9 ivivG~~~vGKTsLi~~~~~~~~~~~~~~t~~~~~~~~~i~~~~~~i--~l~~~d~~~~~~~~~~~~~~~~~~d----~~ 82 (174) T d1wmsa_ 9 VILLGDGGVGKSSLMNRYVTNKFDTQLFHTIGVEFLNKDLEVDGHFV--TMQIWDTAGQERFRSLRTPFYRGSD----CC 82 (174) T ss_dssp EEEECCTTSSHHHHHHHHHHSCCCC----CCSEEEEEEEEEETTEEE--EEEEEECCCCGGGHHHHGGGGTTCS----EE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEECEEEEEEEECCEEE--EEEEEECCCCCHHHHHHHEECCCCE----EE T ss_conf 99981799878999999863813565333155110567999989799--9998312473001021100126865----89 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) ++|+|++.|.++ +.++.|++.++...+ ...+..+|++|||+|.|+- T Consensus 83 i~v~d~~~~~s~-~~i~~~~~~i~~~~~---------------------------------~~~~~~~piiivgnK~Dl~ 128 (174) T d1wmsa_ 83 LLTFSVDDSQSF-QNLSNWKKEFIYYAD---------------------------------VKEPESFPFVILGNKIDIS 128 (174) T ss_dssp EEEEETTCHHHH-HTHHHHHHHHHHHHT---------------------------------CSCTTTSCEEEEEECTTCS T ss_pred EEEEECCCHHHH-HHHHHHHHHHHHHHC---------------------------------CCCCCCCCEEEEECCCCCC T ss_conf 998635886789-999899999998710---------------------------------0367885289995145754 Q ss_pred CCCCHHHHHHHHHHHHHHHHHCCCEEEE-EECHHHHHHHHHHHHHHHH Q ss_conf 5887667899999999999860946888-5120345678999888750 Q Ver_Hs_NP_0570 192 QDFESEKRKVICKTLRFVAHYYGASLMF-TSKSEALLLKIRGVINQLA 238 (351) Q Consensus 192 ~~~D~e~rK~i~r~LR~iAH~yGA~L~F-tSk~e~l~~r~r~~inhl~ 238 (351) ++.-++.. ++.++..+|...+| +|-+.. ..+..+.+.++ T Consensus 129 ~~~v~~ee------~~~~~~~~~~~~~~e~Sak~~--~~I~e~f~~li 168 (174) T d1wmsa_ 129 ERQVSTEE------AQAWCRDNGDYPYFETSAKDA--TNVAAAFEEAV 168 (174) T ss_dssp SCSSCHHH------HHHHHHHTTCCCEEECCTTTC--TTHHHHHHHHH T ss_pred CCCCCHHH------HHHHHHHCCCCCEEEEECCCC--CCHHHHHHHHH T ss_conf 35569899------999999707982799860589--88889999999 No 39 >2atx_A Small GTP binding protein TC10; GTPase, P-loop, alpha-beta; HET: GNP; 2.65A {Homo sapiens} SCOP: c.37.1.8 Probab=99.38 E-value=5.4e-12 Score=99.06 Aligned_columns=158 Identities=18% Q ss_pred EEEEECCCCCHHHHHHHHCCCC--CCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 8998659886377777552766--78887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDRD--EPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r~--e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |+++|..|+||||||+||+... +.+.||+.-.|.......+..- ..++|+.+|-..+..+....++.-. .+ T Consensus 21 i~iiG~~~vGKTsli~~~~~~~~~~~~~~t~~~~~~~~i~~~~~~~---~l~i~D~~g~~~~~~~~~~~~~~~~----~~ 93 (194) T 2atx_A 21 CVVVGDGAVGKTCLLMSYANDAFPEEYVPTVFDHYAVSVTVGGKQY---LLGLYDTAGQEDYDRLRPLSYPMTD----VF 93 (194) T ss_dssp EEEEECTTSSHHHHHHHHHHSSCCCSCCCSSCCCEEEEEESSSCEE---EEEEECCCCSSSSTTTGGGGCTTCS----EE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEECCCEE---EEEEECCCCCCCCHHHHHHHHCCCE----EE T ss_conf 9998179987899999986384377535416543445665349448---8876125321000012333202010----02 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) ++|+|+++++++=.-.++|+..++.+..+ +|+++||+|+|.. T Consensus 94 ilV~d~~~~~sf~~~~~~~~~~~~~~~~~--------------------------------------~~iilVgnK~Dl~ 135 (194) T 2atx_A 94 LICFSVVNPASFQNVKEEWVPELKEYAPN--------------------------------------VPFLLIGTQIDLR 135 (194) T ss_dssp EEEEETTCHHHHHHHHHTHHHHHHHHSTT--------------------------------------CCEEEEEECTTST T ss_pred ECCCCCCHHHHHHHHHHHHHHHHHHCCCC--------------------------------------CCEEEEECCCCCC T ss_conf 00000104678888888766666530678--------------------------------------5379986264555 Q ss_pred CCC-------CHHHHHHHHHHHHHHHHHCCCEEEE-EECHHHHHHHHHHHHHHHH Q ss_conf 588-------7667899999999999860946888-5120345678999888750 Q Ver_Hs_NP_0570 192 QDF-------ESEKRKVICKTLRFVAHYYGASLMF-TSKSEALLLKIRGVINQLA 238 (351) Q Consensus 192 ~~~-------D~e~rK~i~r~LR~iAH~yGA~L~F-tSk~e~l~~r~r~~inhl~ 238 (351) .+- +...+.+...-.+.+|..+|+..+| +|-... ..+..++..++ T Consensus 136 ~~~~~~~~~~~~~~~~v~~~e~~~~a~~~~~~~~~e~Sak~~--~~I~~~f~~li 188 (194) T 2atx_A 136 DDPKTLARLNDMKEKPICVEQGQKLAKEIGACCYVECSALTQ--KGLKTVFDEAI 188 (194) T ss_dssp TCHHHHHHHTTTTCCCCCHHHHHHHHHHHTCSCEEECCTTTC--TTHHHHHHHHH T ss_pred CCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEEEECCC--CCHHHHHHHHH T ss_conf 430367776552025637899999999718922789750488--78889999999 No 40 >smart00174 RHO Rho (Ras homology) subfamily of Ras-like small GTPases; Members of this subfamily of Ras-like small GTPases include Cdc42 and Rac, as well as Rho isoforms. Probab=99.38 E-value=5.2e-12 Score=99.17 Aligned_columns=158 Identities=22% Q ss_pred EEEEECCCCCHHHHHHHHCCC--CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 899865988637777755276--678887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDR--DEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r--~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |+++|+.|.|||||+.||+.. .+.+.||..-.|+.--..++..- -.++|..+|.-.+..|.....+. .-.+ T Consensus 1 ivliGd~~VGKTsli~rf~~~~f~~~~~pTi~~~~~~~i~~~~~~v---~l~iwDtaGqe~~~~l~~~~y~~----a~~~ 73 (174) T smart00174 1 LVVVGDGAVGKTCLLISYTTNAFPEDYVPTVFENYSADVEVDGKPV---ELGLWDTAGQEDYDRLRPLSYPD----TDVF 73 (174) T ss_pred CEEECCCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEECCEEE---EEEECCCCCCCHHHHHHHHHHCC----CCEE T ss_conf 6787159833899999986182266625515432467555778679---99864666662235666876438----8368 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) +||.|++.+.++=.-.+.|++.++++... +|+++||+|.|+- T Consensus 74 ilvydit~~~Sf~~l~~~W~~~i~~~~~~--------------------------------------~piiLVGnK~DL~ 115 (174) T smart00174 74 LICFSVDSPASFENVKEKWYPEVKHFCPN--------------------------------------VPIILVGTKLDLR 115 (174) T ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHCCC--------------------------------------CEEEEEECCCCCC T ss_conf 99986388657899999889999984789--------------------------------------6699971565632 Q ss_pred CCCC-------HHHHHHHHHHHHHHHHHCCCEEEE-EECHHHHHHHHHHHHHHHH Q ss_conf 5887-------667899999999999860946888-5120345678999888750 Q Ver_Hs_NP_0570 192 QDFE-------SEKRKVICKTLRFVAHYYGASLMF-TSKSEALLLKIRGVINQLA 238 (351) Q Consensus 192 ~~~D-------~e~rK~i~r~LR~iAH~yGA~L~F-tSk~e~l~~r~r~~inhl~ 238 (351) .+-. .+++.+-..-.+.+|..+|+-.+| ||-+.. ..+..+..+++ T Consensus 116 ~~~~~~~~~~~~~~~~vs~~e~~~~a~~~~~~~y~EtSAktg--~nV~e~F~~l~ 168 (174) T smart00174 116 NDEDTLEELSKKKQEPVTYEQGEALAKRIGAVKYIECSALTQ--EGVREVFEEAI 168 (174) T ss_pred CHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEECCCC--CCHHHHHHHHH T ss_conf 013455554310135688889999999718941688750488--78789999999 No 41 >e2erxa1 c.37.1.8 (A:6-176) di-Ras2 {Human (Homo sapiens) [TaxID:9606]} SCOP: u2erxb_ u2gf0c_ u2gf0d_ u2gf0a1 u2gf0b_ Probab=99.38 E-value=1.6e-11 Score=95.99 Aligned_columns=155 Identities=19% Q ss_pred EEEEECCCCCHHHHHHHHCCC--CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 899865988637777755276--678887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDR--DEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r--~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |+++|..|+||||||+|+... .+.+.||++-.|.-....++..- ..++|+.+|......+....++ ..-.+ T Consensus 5 I~vvG~~~vGKTsli~~~~~~~~~~~~~~t~~~~~~~~~~~~~~~~---~~~i~d~~g~~~~~~~~~~~~~----~~~~~ 77 (171) T e2erxa1 5 VAVFGAGGVGKSSLVLRFVKGTFRESYIPTVEDTYRQVISCDKSIC---TLQITDTTGSHQFPAMQRLSIS----KGHAF 77 (171) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEECCEEE---EEEEEECCCCHHHHHHHHHHCC----CCCEE T ss_conf 9998079987999999986382166624302200257998746478---9999730561023343022115----87269 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) ++|+|++++.++ +.+..|.+.++..-. ++-.+|++|||+|+|. T Consensus 78 i~v~d~~~~~s~-~~~~~~~~~l~~~~~-----------------------------------~~~~~piiivgnK~Dl- 120 (171) T e2erxa1 78 ILVYSITSRQSL-EELKPIYEQICEIKG-----------------------------------DVESIPIMLVGNKCDE- 120 (171) T ss_pred EEEECCCCCCCH-HHHHHHHHHHHHHHC-----------------------------------CCCCCCEEEEEECCCC- T ss_conf 999717742007-899999754666402-----------------------------------6788527999731356- Q ss_pred CCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHH Q ss_conf 58876678999999999998609468885120345678999888750 Q Ver_Hs_NP_0570 192 QDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLA 238 (351) Q Consensus 192 ~~~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r~r~~inhl~ 238 (351) .+.+.+...-.+.+|..+|+.++++|-... ..+..+.+-++ T Consensus 121 ----~~~~~i~~~~~~~~~~~~~~~~~~~Sak~g--~gi~e~f~~i~ 161 (171) T e2erxa1 121 ----SPSREVQSSEAEALARTWKCAFMETSAKLN--HNVKELFQELL 161 (171) T ss_pred ----CCCCCCCHHHHHHHHHHCCCCEEEEECCCC--CCHHHHHHHHH T ss_conf ----633354478999999964992899970589--68789999999 No 42 >2hxs_A RAB-26, RAS-related protein RAB-28; GTPase, signaling protein; HET: G3D; 1.10A {Homo sapiens} Probab=99.38 E-value=1.4e-11 Score=96.44 Aligned_columns=167 Identities=19% Q ss_pred EEEEECCCCCHHHHHHHHCCC--CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 899865988637777755276--678887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDR--DEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r--~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |+++|+.++|||||++||... .+.+.||++.||........+...- ..++|+.+|-..+..+.+..+.... .+ T Consensus 9 i~iiG~~~vGKSsli~~~~~~~~~~~~~~T~~~~~~~~~v~~~~~~~~-~~~i~D~~g~~~~~~~~~~~~~~~~----~~ 83 (178) T 2hxs_A 9 IVVLGDGASGKTSLTTCFAQETFGKQYKQTIGLDFFLRRITLPGNLNV-TLQIWDIGGQTIGGKMLDKYIYGAQ----GV 83 (178) T ss_dssp EEEECCTTSSHHHHHHHHHGGGTTHHHHHTTTSSEEEEEEEETTTEEE-EEEEEECTTCCTTCTTHHHHHTTCS----EE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEECCCCCEEE-EEEEEECCCCCCCCCCCCCCCCCCC----CC T ss_conf 999807998899999998628337762222554235453223201035-6777531474312211211121000----00 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) ++|+|+++|++ ++.++.|+..+++..... +..+|+++||+|+|+ T Consensus 84 i~v~d~~~~~s-~~~~~~~~~~i~~~~~~~----------------------------------~~~~~iilV~nK~Dl- 127 (178) T 2hxs_A 84 LLVYDITNYQS-FENLEDWYTVVKKVSEES----------------------------------ETQPLVALVGNKIDL- 127 (178) T ss_dssp EEEEETTCHHH-HHTHHHHHHHHHHHHHHH----------------------------------TCCCEEEEEEECGGG- T ss_pred EEEEECCCCCC-CCCHHHHHHHHHHHHCCC----------------------------------CCCCEEEEEECCCCC- T ss_conf 01322024554-110124567775310024----------------------------------656302333023441- Q ss_pred CCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHH-HHHHHHHHHCCCCCCC Q ss_conf 58876678999999999998609468885120345678-9998887505777773 Q Ver_Hs_NP_0570 192 QDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLK-IRGVINQLAFGIDKSK 245 (351) Q Consensus 192 ~~~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r-~r~~inhl~FG~~~~k 245 (351) .+.+.+...-.+.+|..+|+..+++|-....... ....|...+++....| T Consensus 128 ----~~~~~v~~~~~~~~~~~~~~~~~~~Sa~~~~~I~e~f~~i~~~i~~~~~~k 178 (178) T 2hxs_A 128 ----EHMRTIKPEKHLRFCQENGFSSHFVSAKTGDSVFLCFQKVAAEILGIKLNK 178 (178) T ss_dssp ----GGGCSSCHHHHHHHHHHHTCEEEEECTTTCTTHHHHHHHHHHHHTTCCCCC T ss_pred ----HHHHCCCHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCC T ss_conf ----022202458899999964990899961578788899999999998621269 No 43 >e1z0ja1 c.37.1.8 (A:2-168) Rab-22a {Mouse (Mus musculus) [TaxID:10090]} SCOP: u1yvda1 u2fg5a1 Probab=99.37 E-value=3.6e-11 Score=93.83 Aligned_columns=154 Identities=20% Q ss_pred EEEEECCCCCHHHHHHHHCCC--CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 899865988637777755276--678887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDR--DEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r--~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |+++|+.++|||||++|++.. .+.+.||.+.+|..-.-...+... ..++|+.+|......+....++ ....+ T Consensus 7 I~iiG~~~~GKTsLl~~l~~~~~~~~~~~t~~~~~~~~~~~~~~~~~--~l~i~d~~g~~~~~~~~~~~~~----~~~~~ 80 (167) T e1z0ja1 7 VCLLGDTGVGKSSIMWRFVEDSFDPNINPTIGASFMTKTVQYQNELH--KFLIWDTAGLERFRALAPMYYR----GSAAA 80 (167) T ss_pred EEEECCCCCCHHHHHHHHHCCCCCCCCCCCCHHHCCEEEEEECCCEE--EEEEEECCCCHHHHHHHHCCCC----CCEEE T ss_conf 89980799889999999864822565453001100002355458158--9997311571245442000147----86189 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) ++|+|++.+. -+..++.|++..++ ......|++|||+|+|. T Consensus 81 i~v~d~~~~~-s~~~~~~~~~~~~~-------------------------------------~~~~~~~iiivgnK~Dl- 121 (167) T e1z0ja1 81 IIVYDITKEE-TFSTLKNWVRELRQ-------------------------------------HGPPSIVVAIAGNKCDL- 121 (167) T ss_pred EEEEECCCCH-HHHHHHHHHHHHHH-------------------------------------HCCCCEEEEEEEECCCC- T ss_conf 9996256203-67888889999986-------------------------------------05885378997403342- Q ss_pred CCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHH Q ss_conf 58876678999999999998609468885120345678999888750 Q Ver_Hs_NP_0570 192 QDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLA 238 (351) Q Consensus 192 ~~~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r~r~~inhl~ 238 (351) .+.+.+...-.+.+|..+|+..+.+|-... ..+..+...++ T Consensus 122 ----~~~~~v~~~~~~~~~~~~~~~~~e~Sa~~~--~~i~elf~~i~ 162 (167) T e1z0ja1 122 ----TDVREVMERDAKDYADSIHAIFVETSAKNA--ININELFIEIS 162 (167) T ss_pred ----HHHCCCCHHHHHHHHHHCCCEEEEEECCCC--CCHHHHHHHHH T ss_conf ----011154878999999963986999861689--88889999999 No 44 >cd04132 Rho4_like Rho4-like subfamily. Rho4 is a GTPase that controls septum degradation by regulating secretion of Eng1 or Agn1 during cytokinesis. Rho4 also plays a role in cell morphogenesis. Rho4 regulates septation and cell morphology by controlling the actin cytoskeleton and cytoplasmic microtubules. The localization of Rho4 is modulated by Rdi1, which may function as a GDI, and by Rga9, which is believed to function as a GAP. In S. pombe, both Rho4 deletion and Rho4 overexpression result in a defective cell wall, suggesting a role for Rho4 in maintaining cell wall integrity. Most Rho proteins contain a lipid modification site at the C-terminus, with a typical sequence motif CaaX, where a = an aliphatic amino acid and X = any amino acid. Lipid binding is essential for membrane attachment, a key feature of most Rho proteins. Probab=99.37 E-value=1e-11 Score=97.26 Aligned_columns=160 Identities=19% Q ss_pred CEEEEEECCCCCHHHHHHHHCCC--CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEE Q ss_conf 45899865988637777755276--6788875310002211101578711178889715785420211000042351206 Q Ver_Hs_NP_0570 32 KFVFFIGSKNGGKTTIILRCLDR--DEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTF 109 (351) Q Consensus 32 k~v~~vGsk~~GKTTli~Rfl~r--~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~ 109 (351) |-|+++|+.+.|||||++||... .+.+.||++-+|..-.....+... -.++|..+|.-.+..|...-.+ ..- T Consensus 1 ~KVvliGd~~VGKTsli~r~~~~~F~~~~~~Ti~~~~~~~~~~~~~~~v--~l~iwDtaGqe~f~~l~~~~~~----~a~ 74 (187) T cd04132 1 KKIVVVGDGGCGKTCLLIVYSQGKFPEEYVPTVFENYVTNIQGPNGKII--ELALWDTAGQEEYDRLRPLSYP----DVD 74 (187) T ss_pred CEEEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEECCCEEE--EEEEECCCCCHHHHHHHHHHHC----CCC T ss_conf 9689981798328999988761822676465157678999997388189--9986148775245778887724----897 Q ss_pred EEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEEC Q ss_conf 77888736984689999999999999999999999852695378999999998414667760011106887799712100 Q Ver_Hs_NP_0570 110 SLVLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYD 189 (351) Q Consensus 110 ~viivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD 189 (351) .++||.|++.|.++=.-.+.|+..+++.... +|++|||+|.| T Consensus 75 ~~ilvyDit~~~Sf~~~~~~W~~~i~~~~~~--------------------------------------~piilVGNK~D 116 (187) T cd04132 75 VLLICYAVDNPTSLDNVEDKWFPEVNHFCPG--------------------------------------TPIMLVGLKTD 116 (187) T ss_pred EEEEEEECCCHHHHHHHHHHHHHHHHHHCCC--------------------------------------CEEEEEECCCC T ss_conf 5899986599789999998778999984589--------------------------------------77999841675 Q ss_pred CCCCCCHHHHHHHHHHHHHHHHHCCCEEEE-EECHHHHHHHHHHHHHHHH Q ss_conf 015887667899999999999860946888-5120345678999888750 Q Ver_Hs_NP_0570 190 VFQDFESEKRKVICKTLRFVAHYYGASLMF-TSKSEALLLKIRGVINQLA 238 (351) Q Consensus 190 ~F~~~D~e~rK~i~r~LR~iAH~yGA~L~F-tSk~e~l~~r~r~~inhl~ 238 (351) +..+ ....|.+--.-.+.+|-..|+..+| +|-+.. ..+-.+...++ T Consensus 117 L~~~-~~~~r~V~~~e~~~~a~~~~~~~y~EtSAk~g--~nV~e~F~~l~ 163 (187) T cd04132 117 LRKD-KNLDRKVTPAQAESVAKKQGAFAYLECSAKTM--ENVEEVFDTAI 163 (187) T ss_pred CHHH-HCCCCCCCHHHHHHHHHHCCCCEEEEEEECCC--CCHHHHHHHHH T ss_conf 1223-11136789889999999738932689861278--88789999999 No 45 >cd04116 Rab9 Rab9 subfamily. Rab9 is found in late endosomes, together with mannose 6-phosphate receptors (MPRs) and the tail-interacting protein of 47 kD (TIP47). Rab9 is a key mediator of vesicular transport from late endosomes to the trans-Golgi network (TGN) by redirecting the MPRs. Rab9 has been identified as a key component for the replication of several viruses, including HIV1, Ebola, Marburg, and measles, making it a potential target for inhibiting a variety of viruses. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site at the C-terminus, with sequence motifs CC, CX Probab=99.37 E-value=5.3e-11 Score=92.74 Aligned_columns=157 Identities=19% Q ss_pred EEEEECCCCCHHHHHHHHCCC--CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 899865988637777755276--678887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDR--DEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r--~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |+++|+.+.||||||.||+.. ++.+.||++.+|..-.....+... -.++|..+|.-.+..|....++..+ .+ T Consensus 8 ivliGd~~vGKTsLi~rf~~~~f~~~~~~tig~~~~~k~i~~~~~~~--~l~i~Dtag~e~~~~l~~~~~~~~~----~~ 81 (170) T cd04116 8 VILLGDGGVGKSSLMNRYVTNKFDTQLFHTIGVEFLNKDLEVDGHFV--TLQIWDTAGQERFRSLRTPFYRGSD----CC 81 (170) T ss_pred EEEECCCCCCHHHHHHHHHCCCCCCCCCCCEEECCEEEECCCCCCEE--EEEEECCCCCCHHHHHHHHHHCCCC----EE T ss_conf 99980799548999988753811777347323110220000479648--9998707898101231157631898----48 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) +||.|+++++++=. +..|++.+.++.+ .-.+-.+|++|||+|.|+ T Consensus 82 iivydit~~~Sf~~-i~~w~~e~~~~~~---------------------------------~~~~~~ipiilVGNK~DL- 126 (170) T cd04116 82 LLTFAVDDSQSFQN-LSNWKKEFIYYAD---------------------------------VKEPESFPFVVLGNKNDI- 126 (170) T ss_pred EEEEECCCHHHHHH-HHHHHHHHHHHCC---------------------------------CCCCCCCEEEEEECCCCC- T ss_conf 99985499768999-9999999998603---------------------------------577897079998354220- Q ss_pred CCCCHHHHHHHHHHHHHHHHHCCCEEEE-EECHHHHHHHHHHHHHHHH Q ss_conf 5887667899999999999860946888-5120345678999888750 Q Ver_Hs_NP_0570 192 QDFESEKRKVICKTLRFVAHYYGASLMF-TSKSEALLLKIRGVINQLA 238 (351) Q Consensus 192 ~~~D~e~rK~i~r~LR~iAH~yGA~L~F-tSk~e~l~~r~r~~inhl~ 238 (351) +.|.+...-.+.+|..+|...+| +|-+.+ .++..+-..++ T Consensus 127 -----~~r~V~~~e~~~~~~~~~~~~~~E~SAk~g--~nv~~~F~~l~ 167 (170) T cd04116 127 -----PERQVSTEEAQAWCRENGDYPYFETSAKDA--TNVAAAFEEAV 167 (170) T ss_pred -----HHHCCHHHHHHHHHHHCCCCEEEEEECCCC--CCHHHHHHHHH T ss_conf -----111011789999999707971789860489--88789999998 No 46 >e1z06a1 c.37.1.8 (A:32-196) Rab-33b {Mouse (Mus musculus) [TaxID:10090]} Probab=99.37 E-value=2e-11 Score=95.44 Aligned_columns=158 Identities=17% Q ss_pred EEEEECCCCCHHHHHHHHCCCC--CCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 8998659886377777552766--78887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDRD--EPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r~--e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |+++|..|+|||||++|++... +.+.||.+.+|.--.....+..- ..++|+.+|..... .......--....+ T Consensus 5 I~iiG~~~vGKTsli~~~~~~~~~~~~~~t~~~~~~~~~~~~~~~~~--~~~i~d~~~~~~~~---~~~~~~~~~~~~~~ 79 (165) T e1z06a1 5 IIVIGDSNVGKTCLTYRFCAGRFPDRTEATIGVDFRERAVDIDGERI--KIQLWDTAGQERFR---KSMVQHYYRNVHAV 79 (165) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEECCCEEEEEEECCCEE--EEEEEECCCCCCHH---HHHHHHHHCCCCEE T ss_conf 99982699878999999863823676243100001026764189179--99985035753012---34314330143368 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) ++|+|++++.+ ++.++.|+..++++... ..+|+++||+|.|+ T Consensus 80 ilv~d~~~~~s-~~~i~~~~~~i~~~~~~------------------------------------~~~piiivgnK~Dl- 121 (165) T e1z06a1 80 VFVYDMTNMAS-FHSLPAWIEECKQHLLA------------------------------------NDIPRILVGNKCDL- 121 (165) T ss_pred EEEEECCCCCC-HHHHHHHHHHHHHHHCC------------------------------------CCCCEEEEEECCCC- T ss_conf 99875056565-67898899999986034------------------------------------78838999715684- Q ss_pred CCCCHHHHHHHHHHHHHHHHHCCCEEEE-EECHHHHHHHHHHHHHHHH Q ss_conf 5887667899999999999860946888-5120345678999888750 Q Ver_Hs_NP_0570 192 QDFESEKRKVICKTLRFVAHYYGASLMF-TSKSEALLLKIRGVINQLA 238 (351) Q Consensus 192 ~~~D~e~rK~i~r~LR~iAH~yGA~L~F-tSk~e~l~~r~r~~inhl~ 238 (351) .+++++.-.-++.+|..+++.++. ++|+-.-..++..+--+|| T Consensus 122 ----~~~~~v~~~~~~~~~~~~~~~~~e~SAK~~~~~~nv~~~f~~l~ 165 (165) T e1z06a1 122 ----RSAIQVPTDLAQKFADTHSMPLFETSAKNPNDNDHVEAIFMTLA 165 (165) T ss_pred ----HHCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHC T ss_conf ----00046798999999996599499985377877747789998709 No 47 >cd04108 Rab36_Rab34 Rab34/Rab36 subfamily. Rab34, found primarily in the Golgi, interacts with its effector, Rab-interacting lysosomal protein (RILP). This enables its participation in microtubular dynenin-dynactin-mediated repositioning of lysosomes from the cell periphery to the Golgi. A Rab34 (Rah) isoform that lacks the consensus GTP-binding region has been identified in mice. This isoform is associated with membrane ruffles and promotes macropinosome formation. Rab36 has been mapped to human chromosome 22q11.2, a region that is homozygously deleted in malignant rhabdoid tumors (MRTs). However, experimental assessments do not implicate Rab36 as a tumor suppressor that would enable tumor formation through a loss-of-function mechanism. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further re Probab=99.37 E-value=2.7e-11 Score=94.66 Aligned_columns=157 Identities=22% Q ss_pred EEEEECCCCCHHHHHHHHCCC--CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 899865988637777755276--678887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDR--DEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r--~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |+++|+.+.|||||+.||... .+.+.||++.+|.--+....+... -.++|..+|--.+..+.+.-....+. + T Consensus 3 ivliGd~~VGKTsli~rf~~~~f~~~y~~Tig~d~~~k~~~~~~~~i--~l~iwDtaG~e~~~~~~~~~~~~a~~----~ 76 (170) T cd04108 3 VIVVGDLSVGKTCLINRFCKDVFDKNYKATIGVDFEMERFEILGVPF--SLQLWDTAGQERFKCIASTYYRGAQA----I 76 (170) T ss_pred EEEEECCCCCHHHHHHHHHCCEECCCCCCEEEEEEEEEEEEECCEEE--EEEEEECCCCHHHHHHHHHHCCCCCE----E T ss_conf 89981698548998888762822786244256678899875188379--99985368860245666754048880----8 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) +||+|+++++++ +.+..|++.+.+... |-.+|+++||+|+|+. T Consensus 77 ilvyDit~~~Sf-~~~~~w~~~~~~~~~------------------------------------~~~~~i~LVGnK~DL~ 119 (170) T cd04108 77 IIVFDLTDVASL-EHTRQWLEDALKEND------------------------------------PSSVLLFLVGTKKDLS 119 (170) T ss_pred EEEEECCCHHHH-HHHHHHHHHHHHHHC------------------------------------CCCCEEEEEECCCCCC T ss_conf 999754986578-999999999987407------------------------------------9996899983560104 Q ss_pred CCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHH Q ss_conf 58876678999999999998609468885120345678999888750 Q Ver_Hs_NP_0570 192 QDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLA 238 (351) Q Consensus 192 ~~~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r~r~~inhl~ 238 (351) +..++..+-+--+-+|..+|+..+.+|-+.. .++..+-.+++ T Consensus 120 ---~~~~~~~~~~~~~~~a~~~~~~~fEtSAktg--~nV~e~F~~ia 161 (170) T cd04108 120 ---SPAQYALMEQDAIKLAAEMQAEYWSVSALSG--ENVREFFFRVA 161 (170) T ss_pred ---CCCCCEECHHHHHHHHHHCCCCEEEEECCCC--CCHHHHHHHHH T ss_conf ---5311200378999999965995999972588--78789999999 No 48 >cd01862 Rab7 Rab7 subfamily. Rab7 is a small Rab GTPase that regulates vesicular traffic from early to late endosomal stages of the endocytic pathway. The yeast Ypt7 and mammalian Rab7 are both involved in transport to the vacuole/lysosome, whereas Ypt7 is also required for homotypic vacuole fusion. Mammalian Rab7 is an essential participant in the autophagic pathway for sequestration and targeting of cytoplasmic components to the lytic compartment. Mammalian Rab7 is also proposed to function as a tumor suppressor. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site at the C- Probab=99.36 E-value=3.2e-11 Score=94.19 Aligned_columns=160 Identities=22% Q ss_pred EEEEECCCCCHHHHHHHHCCC--CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 899865988637777755276--678887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDR--DEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r--~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |++||+.|.||||||.||+.. .+.+.||++.+|.--.-.-.+... ..++|..+|.-.+..|...-++. .-.+ T Consensus 3 ivliGd~~vGKTsli~r~~~~~f~~~y~~Tig~~~~~k~i~~~~~~~--~l~i~Dt~G~e~~~~l~~~~~~~----a~~~ 76 (172) T cd01862 3 VIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVTVDDKLV--TLQIWDTAGQERFQSLGVAFYRG----ADCC 76 (172) T ss_pred EEEECCCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEECCEEE--EEEEEECCCCCCHHHHHHHHHCC----CCEE T ss_conf 89981798448999999862810665355200157788999988799--99998668993003577887238----9679 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) +||.|++.++++=.- ..|++.+..+.. .-.+-.+|++|||+|.|+ T Consensus 77 ilvydit~~~Sf~~i-~~w~~e~~~~~~---------------------------------~~~~~~iP~ilVGnK~Dl- 121 (172) T cd01862 77 VLVYDVTNPKSFESL-DSWRDEFLIQAS---------------------------------PSDPENFPFVVLGNKIDL- 121 (172) T ss_pred EEEEECCCHHHHHHH-HHHHHHHHHHCC---------------------------------CCCCCCCEEEEECCCCCH- T ss_conf 999856985578999-999999998638---------------------------------777886079997141000- Q ss_pred CCCCHHHHHHHHHHHHHHHHHCCCEEEE-EECHHHHHHH--HHHHHHHHH Q ss_conf 5887667899999999999860946888-5120345678--999888750 Q Ver_Hs_NP_0570 192 QDFESEKRKVICKTLRFVAHYYGASLMF-TSKSEALLLK--IRGVINQLA 238 (351) Q Consensus 192 ~~~D~e~rK~i~r~LR~iAH~yGA~L~F-tSk~e~l~~r--~r~~inhl~ 238 (351) .++|.+--.-.+-+|-.+|...+| +|-+...... |..++..+. T Consensus 122 ----~~~r~v~~~e~~~~a~~~~~~~~~e~SAk~~~nV~e~F~~l~~~~~ 167 (172) T cd01862 122 ----EEKRQVSTKKAQQWCQSNGNIPYFETSAKEAINVEQAFETIARKAL 167 (172) T ss_pred ----HHHCCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHH T ss_conf ----1211531789999999707960799860489787899999999999 No 49 >cd01863 Rab18 Rab18 subfamily. Mammalian Rab18 is implicated in endocytic transport and is expressed most highly in polarized epithelial cells. However, trypanosomal Rab, TbRAB18, is upregulated in the BSF (Blood Stream Form) stage and localized predominantly to elements of the Golgi complex. In human and mouse cells, Rab18 has been identified in lipid droplets, organelles that store neutral lipids. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site at the C-terminus, with sequence motifs CC, CXC, or CCX. Lipid binding is essential for membrane attachment, a key feature of mos Probab=99.36 E-value=3.4e-11 Score=94.00 Aligned_columns=154 Identities=21% Q ss_pred EEEEECCCCCHHHHHHHHCCC--CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 899865988637777755276--678887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDR--DEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r--~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |++||+.|.||||||.||+.. .+.+.||++.||. .+.-.-+..+=-..+|..+|--.+..|.+...+.-+ .+ T Consensus 3 iv~iG~~~VGKTsli~r~~~~~f~~~~~~Ti~~~~~--~k~i~~~~~~~~l~iwDt~G~e~~~~l~~~~~~~~~----~~ 76 (161) T cd01863 3 ILLIGDSGVGKSSLLLRFTDDTFDPDLAATIGVDFK--VKTLTVDGKKVKLAIWDTAGQERFRTLTSSYYRGAQ----GV 76 (161) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEE--EEEEEECCEEEEEEEEECCCCCHHHHHHHHHCCCCC----EE T ss_conf 899807996589999998628207765651000245--889989896999999754887101245475435998----79 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) ++|.|++.+.++=. +..|++.++.+... -.+|++|||+|+|. T Consensus 77 i~vfd~t~~~Sf~~-i~~w~~~i~~~~~~------------------------------------~~~~~ilvGNK~Dl- 118 (161) T cd01863 77 ILVYDVTRRDTFTN-LETWLNELETYSTN------------------------------------NDIVKMLVGNKIDK- 118 (161) T ss_pred EEEEECCCHHHHHH-HHHHHHHHHHHCCC------------------------------------CCCEEEEECCCCCC- T ss_conf 99985698679999-99999999973389------------------------------------99389996123343- Q ss_pred CCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHH Q ss_conf 58876678999999999998609468885120345678999888750 Q Ver_Hs_NP_0570 192 QDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLA 238 (351) Q Consensus 192 ~~~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r~r~~inhl~ 238 (351) +.|.+...-.+-+|-.+|+..+.+|-+.. ..+..+..+++ T Consensus 119 -----~~r~v~~~e~~~~a~~~~~~~~e~SAk~~--~nv~e~F~~l~ 158 (161) T cd01863 119 -----ENREVTREEGLKFARKHNMLFIETSAKTR--DGVQQAFEELV 158 (161) T ss_pred -----CCCCCCHHHHHHHHHHCCCEEEEEECCCC--CCHHHHHHHHH T ss_conf -----00048888999999966992999970589--78789999999 No 50 >cd04176 Rap2 Rap2 subgroup. The Rap2 subgroup is part of the Rap subfamily of the Ras family. It consists of Rap2a, Rap2b, and Rap2c. Both isoform 3 of the human mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) and Traf2- and Nck-interacting kinase (TNIK) are putative effectors of Rap2 in mediating the activation of c-Jun N-terminal kinase (JNK) to regulate the actin cytoskeleton. In human platelets, Rap2 was shown to interact with the cytoskeleton by binding the actin filaments. In embryonic Xenopus development, Rap2 is necessary for the Wnt/beta-catenin signaling pathway. The Rap2 interacting protein 9 (RPIP9) is highly expressed in human breast carcinomas and correlates with a poor prognosis, suggesting a role for Rap2 in breast cancer oncogenesis. Rap2b, but not Rap2a, Rap2c, Rap1a, or Rap1b, is expressed in human red blood cells, where it is believed to be involved in vesiculation. A number of additional effector proteins for Rap2 have been identified, incl Probab=99.35 E-value=3.3e-11 Score=94.06 Aligned_columns=154 Identities=17% Q ss_pred EEEEECCCCCHHHHHHHHCCC--CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 899865988637777755276--678887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDR--DEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r--~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |++||+.+.||||||+||+.. .+.+.||++ |+.--+-...+... ..++|..+|...+..|...-++.. -.+ T Consensus 4 IvvvGd~~VGKTsli~rf~~~~f~~~y~~Ti~-~~~~k~i~~~~~~~--~l~i~Dt~G~e~~~~~~~~~~~~a----~~~ 76 (163) T cd04176 4 VVVLGSGGVGKSALTVQFVSGTFIEKYDPTIE-DFYRKEIEVDSSPS--VLEILDTAGTEQFASMRDLYIKNG----QGF 76 (163) T ss_pred EEEEECCCCCHHHHHHHHHCCEECCCCCCCCC-CEEEEEEEECCEEE--EEEEEECCCCCHHHHHHHHHCCCC----CEE T ss_conf 89970798548999988763800776563100-00478998889689--999874688712456777425799----869 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) +||.|++.+.+ ++.++.|++.+.+... +-++|++|||+|.|+ T Consensus 77 ilvydi~~~~S-f~~i~~~~~~i~~~~~------------------------------------~~~~piilvGnK~Dl- 118 (163) T cd04176 77 IVVYSLVNQQT-FQDIKPMRDQIVRVKG------------------------------------YEKVPIILVGNKVDL- 118 (163) T ss_pred EEEEECCCHHH-HHHHHHHHHHHHHHCC------------------------------------CCCCEEEEEECCCCH- T ss_conf 99976699768-8999998765675318------------------------------------998289997332001- Q ss_pred CCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHH Q ss_conf 58876678999999999998609468885120345678999888750 Q Ver_Hs_NP_0570 192 QDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLA 238 (351) Q Consensus 192 ~~~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r~r~~inhl~ 238 (351) ...|++--.-...+|-.+|+..+.+|-+.+ .++..+...++ T Consensus 119 ----~~~r~V~~~e~~~~a~~~~~~y~E~SAk~~--~nV~e~F~~l~ 159 (163) T cd04176 119 ----ESEREVSSAEGRALAEEWGCPFMETSAKSK--TMVNELFAEIV 159 (163) T ss_pred ----HHHCCCCHHHHHHHHHHCCCCEEEEECCCC--CCHHHHHHHHH T ss_conf ----111024637899999963995899970479--88789999999 No 51 >d3raba_ c.37.1.8 (A:) Rab3a {Rat (Rattus norvegicus)} SCOP: d1zbda_ Probab=99.35 E-value=1.3e-11 Score=96.70 Aligned_columns=154 Identities=17% Q ss_pred EEEEECCCCCHHHHHHHHC--CCCCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 8998659886377777552--76678887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCL--DRDEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl--~r~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |+++|..|+||||||+|+. .-.+.+.||.+.+|........+... ..++|+.+|......+....++... .+ T Consensus 8 i~iiG~~~vGKTsLi~~~~~~~~~~~~~~~~~~~~~~~~i~~~~~~~--~~~i~d~~g~~~~~~~~~~~~~~~d----~~ 81 (169) T d3raba_ 8 ILIIGNSSVGKTSFLFRYADDSFTPAFVSTVGIDFKVKTIYRNDKRI--KLQIWDTAGQERYRTITTAYYRGAM----GF 81 (169) T ss_dssp EEEECSTTSSHHHHHHHHHHSCCCSSCCCCCSEEEEEEEEEETTEEE--EEEEEEECCSGGGHHHHHTTTTTCC----EE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEEECCEEE--EEEEEECCCCCHHHHHHHHHCCCCC----EE T ss_conf 99983699879999999865801544022011035789999988689--9998515773112232121101345----78 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) ++|+|++.+.++ +.++.|+..++..... .+|+++||+|.|+ T Consensus 82 i~v~d~~~~~s~-~~~~~~~~~i~~~~~~-------------------------------------~~pivvv~nK~Dl- 122 (169) T d3raba_ 82 ILMYDITNEESF-NAVQDWSTQIKTYSWD-------------------------------------NAQVLLVGNKCDM- 122 (169) T ss_dssp EEEEETTCHHHH-HTHHHHHHHHHHHCCS-------------------------------------CCEEEEEEECTTC- T ss_pred EEEEECCCCCHH-HHHHHHHHHHHHHHCC-------------------------------------CCCEEHHHHCCCC- T ss_conf 998622554205-6688899998765306-------------------------------------8300000001232- Q ss_pred CCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHH Q ss_conf 58876678999999999998609468885120345678999888750 Q Ver_Hs_NP_0570 192 QDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLA 238 (351) Q Consensus 192 ~~~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r~r~~inhl~ 238 (351) .+.+.+.-.-.+.+|-.+|...+++|-... ..+..+..++. T Consensus 123 ----~~~~~v~~~~~~~~~~~~~~~~~~~Sa~~g--~~i~e~f~~li 163 (169) T d3raba_ 123 ----EDERVVSSERGRQLADHLGFEFFEASAKDN--INVKQTFERLV 163 (169) T ss_dssp ----GGGCCSCHHHHHHHHHHHTCEEEECBTTTT--BSHHHHHHHHH T ss_pred ----CCCCCCCHHHHHHHHHHCCCEEEEEECCCC--CCHHHHHHHHH T ss_conf ----111257888999999955983999872689--88889999999 No 52 >e2gjsa1 c.37.1.8 (A:91-258) Rad {Human (Homo sapiens) [TaxID:9606]} SCOP: u2gjsb_ Probab=99.35 E-value=2.5e-11 Score=94.81 Aligned_columns=155 Identities=16% Q ss_pred EEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEEEE Q ss_conf 89986598863777775527667888753100022111015787111788897157854202110000423512067788 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDRDEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSLVL 113 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~vii 113 (351) |+++|+.|+|||||++||......+.+++..++ |.+...-++..- ..|+|..+|-..+..+.+..+..... +++ T Consensus 4 I~iiG~~~vGKTsli~~~~~~~~~~~~~~~~~~-~~~~i~i~~~~~-~l~i~D~~G~~~~~~~~~~~~~~~d~----~il 77 (168) T e2gjsa1 4 VLLLGAPGVGKSALARIFGGVEDGPEAEAAGHT-YDRSIVVDGEEA-SLMVYDIWEQDGGRWLPGHCMAMGDA----YVI 77 (168) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCEEEEE-EEEEEEECCEEE-EEEEEEEEEECCCCCCCCCCCCCEEE----EEE T ss_conf 999807998799999988356267523506888-999999714157-99999753103210002001245289----999 Q ss_pred EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCCCC Q ss_conf 87369846899999999999999999999998526953789999999984146677600111068877997121000158 Q Ver_Hs_NP_0570 114 VLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVFQD 193 (351) Q Consensus 114 vlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F~~ 193 (351) |+|+++++++.. +..|+..+...... -.+|+++||+|.|. T Consensus 78 v~d~t~~~sf~~-~~~~~~~i~~~~~~------------------------------------~~~piiivgnK~Dl--- 117 (168) T e2gjsa1 78 VYSVTDKGSFEK-ASELRVQLRRARQT------------------------------------DDVPIILVGNKSDL--- 117 (168) T ss_pred EEEECCCCCHHH-HHHHHHHHHHHHCC------------------------------------CCCCEEEEEECCCC--- T ss_conf 864023554567-75788999962112------------------------------------67504567531332--- Q ss_pred CCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHH Q ss_conf 876678999999999998609468885120345678999888750 Q Ver_Hs_NP_0570 194 FESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLA 238 (351) Q Consensus 194 ~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r~r~~inhl~ 238 (351) .+.+.+--.-++-+|-.+++..+.+|-+.. ..+..+.+.++ T Consensus 118 --~~~~~v~~~e~~~~~~~~~~~~~e~Sak~~--~~i~~~f~~i~ 158 (168) T e2gjsa1 118 --VRSREVSVDEGRACAVVFDCKFIETSAALH--HNVQALFEGVV 158 (168) T ss_pred --CCCCCCCHHHHHHHHHHCCCCEEEEEECCC--CCHHHHHHHHH T ss_conf --324567989999999965980899970589--78889999999 No 53 >cd04113 Rab4 Rab4 subfamily. Rab4 has been implicated in numerous functions within the cell. It helps regulate endocytosis through the sorting, recycling, and degradation of early endosomes. Mammalian Rab4 is involved in the regulation of many surface proteins including G-protein-coupled receptors, transferrin receptor, integrins, and surfactant protein A. Experimental data implicate Rab4 in regulation of the recycling of internalized receptors back to the plasma membrane. It is also believed to influence receptor-mediated antigen processing in B-lymphocytes, in calcium-dependent exocytosis in platelets, in alpha-amylase secretion in pancreatic cells, and in insulin-induced translocation of Glut4 from internal vesicles to the cell surface. Rab4 is known to share effector proteins with Rab5 and Rab11. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to p Probab=99.35 E-value=3e-11 Score=94.29 Aligned_columns=154 Identities=19% Q ss_pred EEEEECCCCCHHHHHHHHCCC--CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 899865988637777755276--678887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDR--DEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r--~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |++||+.|.||||||.||+.. .+.+.||++.+|.--.-.-.+... ...+|-.+|-.....|...-....+ .+ T Consensus 3 iviiGd~~VGKTsli~~~~~~~f~~~~~~Tig~~~~~~~i~~~~~~~--~l~i~Dt~G~e~~~~l~~~~~~~a~----~~ 76 (161) T cd04113 3 FIIIGSSGTGKSCLLHRFVENKFKEDSQHTIGVEFGSKIIRVGGKRV--KLQIWDTAGQERFRSVTRSYYRGAA----GA 76 (161) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEECCEEE--EEEEEECCCCCHHHHHHHHHCCCCC----EE T ss_conf 89982698558999999862810666564101201358998889699--9998325887013455586426997----79 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) ++|.|++.+.++ +.++.|++.+|..... .+|++|||+|.|+ T Consensus 77 iivydi~~~~Sf-~~i~~w~~~~~~~~~~-------------------------------------~~~iilvgNK~DL- 117 (161) T cd04113 77 LLVYDITNRTSF-EALPTWLSDARALASP-------------------------------------NIVVILVGNKSDL- 117 (161) T ss_pred EEEEECCCHHHH-HHHHHHHHHHHHHCCC-------------------------------------CCEEEEEECCCCC- T ss_conf 999855986689-9999999999872489-------------------------------------9689998324564- Q ss_pred CCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHH Q ss_conf 58876678999999999998609468885120345678999888750 Q Ver_Hs_NP_0570 192 QDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLA 238 (351) Q Consensus 192 ~~~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r~r~~inhl~ 238 (351) .++|.+--.-.+-+|-.+|...+.+|-++. ..+..+-.+++ T Consensus 118 ----~~~r~v~~~e~~~~a~~~~~~~~e~Sak~~--~ni~e~F~~la 158 (161) T cd04113 118 ----ADQREVTFLEASRFAQENGLLFLETSALTG--ENVEEAFLKCA 158 (161) T ss_pred ----CCCCCCCHHHHHHHHHHCCCEEEEEECCCC--CCHHHHHHHHH T ss_conf ----213345889999999965990999971589--88889999999 No 54 >d1vg8a_ c.37.1.8 (A:) Rab7 {Rat (Rattus norvegicus)} SCOP: d1vg0b_ d1vg1a_ d1vg8c_ d1vg8b_ u1yhna_ u1t91a1 d1vg9d_ d1vg9b_ d1vg9f_ Probab=99.35 E-value=9.5e-12 Score=97.49 Aligned_columns=177 Identities=19% Q ss_pred EEEEECCCCCHHHHHHHHCCCC--CCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 8998659886377777552766--78887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDRD--EPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r~--e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |+++|..|+||||||+||+... +.+.||++.+|..-.....+... ..++|+.+|......+...-+..-. ++ T Consensus 5 i~ivG~~~vGKSsLi~~l~~~~~~~~~~~t~~~~~~~~~~~~~~~~~--~~~i~d~~g~~~~~~~~~~~~~~~d----~~ 78 (184) T d1vg8a_ 5 VIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVDDRLV--TMQIWDTAGQERFQSLGVAFYRGAD----CC 78 (184) T ss_dssp EEEECCTTSSHHHHHHHHHHSCCCSSCCCCCSEEEEEEEEESSSCEE--EEEEEEECSSGGGSCSCCGGGTTCS----EE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEECCEEE--EEEEECCCCCHHHCCCCCHHHCCCC----EE T ss_conf 99980799879999999864823676355112356789999736589--9998316431001013421121897----58 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) ++|+|++++.+ +..+..|++.++.+.. .-..-.+|+++||+|+|. T Consensus 79 ilv~d~~~~~s-~~~~~~~~~~i~~~~~---------------------------------~~~~~~~piilv~nK~Dl- 123 (184) T d1vg8a_ 79 VLVFDVTAPNT-FKTLDSWRDEFLIQAS---------------------------------PRDPENFPFVVLGNKIDL- 123 (184) T ss_dssp EEEEETTCHHH-HHTHHHHHHHHHHHHC---------------------------------CSSGGGSCEEEEEECTTS- T ss_pred EEEEEECCCCC-HHHHHHHHHHHHHHHC---------------------------------CCCCCCCEEEEEEEHHCC- T ss_conf 99986047752-6789999999999740---------------------------------148776125656430000- Q ss_pred CCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHH-HHHHHHHHHCCCCCCCEEEEECCCCE Q ss_conf 58876678999999999998609468885120345678-99988875057777730575067757 Q Ver_Hs_NP_0570 192 QDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLK-IRGVINQLAFGIDKSKSICVDQNKPL 255 (351) Q Consensus 192 ~~~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r-~r~~inhl~FG~~~~k~~~~D~~kPl 255 (351) .+.+...-...++.+-.++...+.+|-+...... +...+-..+..-...+.+..|+.+|| T Consensus 124 ----~~~~~~~~~~~~~~~~~~~~~~~e~Sak~g~gI~e~f~~i~~~~~~~~~~~~~~~~~~~~~ 184 (184) T d1vg8a_ 124 ----ENRQVATKRAQAWCYSKNNIPYFETSAKEAINVEQAFQTIARNALKQETEVELYNEFPEPI 184 (184) T ss_dssp ----SCCCSCHHHHHHHHHHTTSCCEEECBTTTTBSHHHHHHHHHHHHHHHHHHHHHHHHSCCCC T ss_pred ----CCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCHHCCCCCCCC T ss_conf ----1336677899999997359728998616897888999999999973251000106788999 No 55 >smart00175 RAB Rab subfamily of small GTPases; Rab GTPases are implicated in vesicle trafficking. Probab=99.34 E-value=2.6e-11 Score=94.78 Aligned_columns=154 Identities=23% Q ss_pred EEEEECCCCCHHHHHHHHCCC--CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 899865988637777755276--678887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDR--DEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r--~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |++||+.+.|||||+.||+.. .+.+.||++.||..-...-.+... ...+|..+|...+..|....++.-+. + T Consensus 3 iviiG~~~vGKTsii~~~~~~~f~~~~~~Ti~~~~~~k~v~~~~~~~--~l~i~Dt~g~e~~~~~~~~~~~~~d~----~ 76 (164) T smart00175 3 IILIGDSGVGKSSLLSRFTDGKFSEDSKSTIGVDFKTKTIEVDGKRV--KLQIWDTAGQERFRSITSSYYRGAVG----A 76 (164) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEEECCEEE--EEEEEECCCCHHHHHHHHHHHCCCCE----E T ss_conf 89982699648999999862810665565022367789999989699--99986469871467777875048976----9 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) ++|+|++.+.++ +.++.|++.++.+... .+|++|||+|.|. T Consensus 77 iivfdi~~~~Sf-~~i~~w~~~i~~~~~~-------------------------------------~~piilvgNK~Dl- 117 (164) T smart00175 77 LLVYDITNRDSF-ENLENWLKELREYADP-------------------------------------NVVIMLVGNKSDL- 117 (164) T ss_pred EEEEECCCHHHH-HHHHHHHHHHHHHCCC-------------------------------------CCEEEEEEECCCC- T ss_conf 999327987799-9999999999972699-------------------------------------9589998511022- Q ss_pred CCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHH Q ss_conf 58876678999999999998609468885120345678999888750 Q Ver_Hs_NP_0570 192 QDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLA 238 (351) Q Consensus 192 ~~~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r~r~~inhl~ 238 (351) ..+|.+--.-.+.+|-.+|+..+-+|-+.. ..+..+..+++ T Consensus 118 ----~~~~~i~~~e~~~~a~~~~~~y~E~Sak~~--~~i~e~F~~l~ 158 (164) T smart00175 118 ----EEQRQVSTEEAQKFAEEHGLLFIETSAKTN--TNVEEAFEELA 158 (164) T ss_pred ----CCCCCCCHHHHHHHHHHCCCEEEEEECCCC--CCHHHHHHHHH T ss_conf ----000258989999999964982999970479--88789999999 No 56 >1x3s_A RAS-related protein RAB-18; GTPase, GNP, structural genomics, NPPSFA, national project on protein structural and functional analyses; HET: GNP; 1.32A {Homo sapiens} SCOP: c.37.1.8 Probab=99.34 E-value=2.5e-11 Score=94.80 Aligned_columns=172 Identities=16% Q ss_pred EEEEECCCCCHHHHHHHHC--CCCCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 8998659886377777552--76678887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCL--DRDEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl--~r~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |+++|..++||||||+|++ ...+...||++.++.+....-.+... .+++|+.+|......+....+..... + T Consensus 18 I~viG~~~vGKTsLi~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~--~~~i~D~~~~~~~~~~~~~~~~~~~~----~ 91 (195) T 1x3s_A 18 ILIIGESGVGKSSLLLRFTDDTFDPELAATIGVDFKVKTISVDGNKA--KLAIWDTAGQERFRTLTPSYYRGAQG----V 91 (195) T ss_dssp EEEECSTTSSHHHHHHHHHHSCCCTTCCCCCSEEEEEEEEEETTEEE--EEEEEEECSSGGGCCSHHHHHTTCCE----E T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEEECCEEE--EEEEECCCCHHHHHHHHHHHHCCCCC----E T ss_conf 89980699879999999865813655332022112578888878788--98850032200223343777225881----2 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) ++|+|++.+.+ +..++.|++.+ ........+|+++||+|+|. T Consensus 92 i~v~d~~~~~S-~~~~~~~~~~i------------------------------------~~~~~~~~~piiiv~nK~Dl- 133 (195) T 1x3s_A 92 ILVYDVTRRDT-FVKLDNWLNEL------------------------------------ETYCTRNDIVNMLVGNKIDK- 133 (195) T ss_dssp EEEEETTCHHH-HHTHHHHHHHH------------------------------------TTCCSCSCCEEEEEEECTTS- T ss_pred EEEEECCCCCC-HHHHHHHHHHH------------------------------------HHHCCCCCCEEEEECCCCCH- T ss_conf 89972367410-11247888766------------------------------------54101245306774265200- Q ss_pred CCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHH-HHHHHHHHHCCCCCCCEEEEECCCC Q ss_conf 58876678999999999998609468885120345678-9998887505777773057506775 Q Ver_Hs_NP_0570 192 QDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLK-IRGVINQLAFGIDKSKSICVDQNKP 254 (351) Q Consensus 192 ~~~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r-~r~~inhl~FG~~~~k~~~~D~~kP 254 (351) +.+.+.-.-++-+|-.+|+.++++|-....... +..-+...++..+......-...+| T Consensus 134 -----~~~~v~~~~~~~~~~~~~~~~~e~Sa~~~~gi~~~f~~i~~~i~~~~~~~~~~~~~~~~ 192 (195) T 1x3s_A 134 -----ENREVDRNEGLKFARKHSMLFIEASAKTCDGVQCAFEELVEKIIQTPGLWESENQNSGP 192 (195) T ss_dssp -----SSCCSCHHHHHHHHHHTTCEEEECCTTTCTTHHHHHHHHHHHHHTSGGGTCC------- T ss_pred -----HHCCCHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCC T ss_conf -----11010178999999962987999851678788899999999997445767643347788 No 57 >cd04141 Rit_Rin_Ric Rit/Rin/Ric subfamily. Rit (Ras-like protein in all tissues), Rin (Ras-like protein in neurons) and Ric (Ras-related protein which interacts with calmodulin) form a subfamily with several unique structural and functional characteristics. These proteins all lack a the C-terminal CaaX lipid-binding motif typical of Ras family proteins, and Rin and Ric contain calmodulin-binding domains. Rin, which is expressed only in neurons, induces neurite outgrowth in rat pheochromocytoma cells through its association with calmodulin and its activation of endogenous Rac/cdc42. Rit, which is ubiquitously expressed in mammals, inhibits growth-factor withdrawl-mediated apoptosis and induces neurite extension in pheochromocytoma cells. Rit and Rin are both able to form a ternary complex with PAR6, a cell polarity-regulating protein, and Rac/cdc42. This ternary complex is proposed to have physiological function in processes such as tumorigenesis. Activated Ric is likely to sign Probab=99.34 E-value=4.3e-11 Score=93.32 Aligned_columns=154 Identities=18% Q ss_pred EEEEECCCCCHHHHHHHHCCCC--CCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 8998659886377777552766--78887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDRD--EPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r~--e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |+++|+.+.||||||+||+... +.+.||++-.|+---..++..- .+.+|..+|--.+..|.+.-.+... .+ T Consensus 5 i~liGd~~VGKTsli~rf~~~~F~~~y~pTi~~~~~~~i~~~~~~v---~l~iwDtaGqe~~~~l~~~~~~~a~----~~ 77 (172) T cd04141 5 IVMLGAGGVGKSAVTMQFISHSFPDYHDPTIEDAYKQQARIDNEPA---LLDILDTAGQAEFTAMRDQYMRCGE----GF 77 (172) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEECCEEE---EEEEECCCCCHHHHHHHHHHCCCCC----EE T ss_conf 9997079843899999987282277656630000478998979589---9986227762135567687514997----38 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) +||.|++.+.++ +.+..| -+.+.+..... .+|++|||+|.|+ T Consensus 78 ilVyditd~~Sf-~~i~~w--------~~~i~~~~~~~----------------------------~~pivlvgNK~DL- 119 (172) T cd04141 78 IICYSVTDRHSF-QEASEF--------KKLITRVRLTE----------------------------DIPLVLVGNKVDL- 119 (172) T ss_pred EEEEECCCHHHH-HHHHHH--------HHHHHHHCCCC----------------------------CCEEEEEECCCHH- T ss_conf 998542897689-999999--------99999740799----------------------------9779998156016- Q ss_pred CCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHH Q ss_conf 58876678999999999998609468885120345678999888750 Q Ver_Hs_NP_0570 192 QDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLA 238 (351) Q Consensus 192 ~~~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r~r~~inhl~ 238 (351) .+.|.+.-.--+.+|-.+|+..+-+|-+.+ .++..+...++ T Consensus 120 ----~~~r~V~~~e~~~~a~~~~~~f~EtSAk~~--~nV~~~F~~l~ 160 (172) T cd04141 120 ----ESQRQVTTEEGRNLAREFNCPFFETSAALR--HYIDDAFHGLV 160 (172) T ss_pred ----HHCCCCCHHHHHHHHHHCCCCEEEEECCCC--CCHHHHHHHHH T ss_conf ----541566778999999965996999970589--88789999999 No 58 >cd04136 Rap_like Rap-like subfamily. The Rap subfamily consists of the Rap1, Rap2, and RSR1. Rap subfamily proteins perform different cellular functions, depending on the isoform and its subcellular localization. For example, in rat salivary gland, neutrophils, and platelets, Rap1 localizes to secretory granules and is believed to regulate exocytosis or the formation of secretory granules. Rap1 has also been shown to localize in the Golgi of rat fibroblasts, zymogen granules, plasma membrane, and microsomal membrane of the pancreatic acini, as well as in the endocytic compartment of skeletal muscle cells and fibroblasts. Rap1 localizes in the nucleus of human oropharyngeal squamous cell carcinomas (SCCs) and cell lines. Rap1 plays a role in phagocytosis by controlling the binding of adhesion receptors (typically integrins) to their ligands. In yeast, Rap1 has been implicated in multiple functions, including activation and silencing of transcription and maintenance of telomeres. Probab=99.33 E-value=4.6e-11 Score=93.16 Aligned_columns=154 Identities=21% Q ss_pred EEEEECCCCCHHHHHHHHCCC--CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 899865988637777755276--678887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDR--DEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r--~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |++||+.|.||||||+||+.. .+.+.||++-.| .+.---....-..++|..+|.-.+..|.+.-++. .-.+ T Consensus 4 iilvGd~~VGKTsli~r~~~~~f~~~~~~ti~~~~---~k~i~v~~~~~~l~iwDtaG~e~~~~l~~~~~~~----a~~~ 76 (163) T cd04136 4 VVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSY---RKQIEVDGQQCMLEILDTAGTEQFTAMRDLYIKN----GQGF 76 (163) T ss_pred EEEEECCCCCHHHHHHHHHCCEECCCCCCCCCCCE---EEEEEECCEEEEEEEEECCCCHHHHHHHHHHHCC----CCEE T ss_conf 89970798438999998862800676565100012---6889888968999988479980356888875116----8828 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) +||.|++.+.++ +.+..|++.+.+..+. -++|++|||+|.|+ T Consensus 77 ilvfdvt~~~Sf-~~i~~~~~~i~~~~~~------------------------------------~~ip~ilVGNK~DL- 118 (163) T cd04136 77 VLVYSITSQSSF-NDLQDLREQILRVKDT------------------------------------ENVPMVLVGNKCDL- 118 (163) T ss_pred EEEEECCCHHHH-HHHHHHHHHHHHHCCC------------------------------------CCCEEEEECCCCCC- T ss_conf 999756997888-9999999999974089------------------------------------99389997244676- Q ss_pred CCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHH Q ss_conf 58876678999999999998609468885120345678999888750 Q Ver_Hs_NP_0570 192 QDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLA 238 (351) Q Consensus 192 ~~~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r~r~~inhl~ 238 (351) .+.|.+.-.-...+|..+|+..+.+|-+.+ .++..+...++ T Consensus 119 ----~~~r~v~~~~~~~~a~~~~~~~~E~Sak~~--~nv~e~F~~l~ 159 (163) T cd04136 119 ----EDERVVSREEGQALARQWGCPFYETSAKSK--INVDEVFADLV 159 (163) T ss_pred ----CCCCCCCHHHHHHHHHHCCCCEEEEECCCC--CCHHHHHHHHH T ss_conf ----465637989999999966995999971479--78789999999 No 59 >cd04123 Rab21 Rab21 subfamily. The localization and function of Rab21 are not clearly defined, with conflicting data reported. Rab21 has been reported to localize in the ER in human intestinal epithelial cells, with partial colocalization with alpha-glucosidase, a late endosomal/lysosomal marker. More recently, Rab21 was shown to colocalize with and affect the morphology of early endosomes. In Dictyostelium, GTP-bound Rab21, together with two novel LIM domain proteins, LimF and ChLim, has been shown to regulate phagocytosis. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site Probab=99.32 E-value=5.9e-11 Score=92.48 Aligned_columns=154 Identities=25% Q ss_pred EEEEECCCCCHHHHHHHHCCC--CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 899865988637777755276--678887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDR--DEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r--~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |++||+.++||||||.||+.. .+.+.||++.+|..-.-...+... -.++|..+|...+..+...-++. .-.+ T Consensus 3 i~~iGd~~vGKTsli~r~~~~~f~~~~~~ti~~~~~~k~i~~~~~~~--~l~iwDt~G~~~~~~~~~~~~~~----a~~~ 76 (162) T cd04123 3 VVLLGEGRVGKTSLVLRYVENKFNEKHESTTQASFFQKTVNIGGKRI--DLAIWDTAGQERYHALGPIYYRD----ADGA 76 (162) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCEE--EEEEEECCCCHHHHHHHHHHHCC----CCEE T ss_conf 89982699658999999862811776454112441355331599389--99973078750235665766148----9868 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) ++|.|++. .+=++.+..|++.+++...+ .+|++|||+|.|+ T Consensus 77 ilvydit~-~~Sf~~i~~w~~~i~~~~~~-------------------------------------~~piilVGNK~Dl- 117 (162) T cd04123 77 ILVYDITD-ADSFQKVKKWIKELKQMRGN-------------------------------------NISLVIVGNKIDL- 117 (162) T ss_pred EEEEECCC-HHHHHHHHHHHHHHHHHCCC-------------------------------------CCEEEEEEEHHHH- T ss_conf 99942798-77899999999989973189-------------------------------------9659998400231- Q ss_pred CCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHH Q ss_conf 58876678999999999998609468885120345678999888750 Q Ver_Hs_NP_0570 192 QDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLA 238 (351) Q Consensus 192 ~~~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r~r~~inhl~ 238 (351) +++|.+-..-.+.+|-.+|+..+.+|-+.. ..+..+...++ T Consensus 118 ----~~~r~V~~~~~~~~a~~~~~~~~E~Sak~~--~nv~e~F~~l~ 158 (162) T cd04123 118 ----ERQRVVSKSEAEEYAKSVGAKHFETSAKTG--KGIEELFLSLA 158 (162) T ss_pred ----HHHCCCCHHHHHHHHHHCCCCEEEEECCCC--CCHHHHHHHHH T ss_conf ----210254778999999964993899971589--78789999999 No 60 >2q3h_A RAS homolog gene family, member U; GTPase, structural genomics, structural genomics consortium, SGC; HET: GDP; 1.73A {Homo sapiens} Probab=99.32 E-value=3.3e-11 Score=94.04 Aligned_columns=172 Identities=17% Q ss_pred CCCCCCHHHCCCCE-----EEEEECCCCCHHHHHHHHCCC--CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCC Q ss_conf 66611011125745-----899865988637777755276--67888753100022111015787111788897157854 Q Ver_Hs_NP_0570 20 NGSEGDGAEIAEKF-----VFFIGSKNGGKTTIILRCLDR--DEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTS 92 (351) Q Consensus 20 ~~~~~~~~~~~ek~-----v~~vGsk~~GKTTli~Rfl~r--~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ 92 (351) +.-+++++.+++.. |+++|..|+||||||+||... .+.+.||..-.| .+....+...-.+++|+.+|.-. T Consensus 4 ~~~~~~~~~~~~~~~k~iKV~iiG~~gvGKTsLi~~l~~~~~~~~~~~t~~~~~---~~~~~~~~~~~~l~i~D~~g~~~ 80 (201) T 2q3h_A 4 PGEPGGRGRAGGAEGRGVKCVLVGDGAVGKTSLVVSYTTNGYPTEYIPTAFDNF---SAVVSVDGRPVRLQLCDTAGQDE 80 (201) T ss_dssp ----------------CEEEEEECSTTSSHHHHHHHHHC--------CCSSEEE---EEEEEETTEEEEEEEEECCCSTT T ss_pred CCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEE---EEEEEECCEEEEEEECCCCCCHH T ss_conf 888777778888888724899870799778999999871765655342255578---99998606056653034652001 Q ss_pred HHHCEEEEECCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCC Q ss_conf 20211000042351206778887369846899999999999999999999998526953789999999984146677600 Q Ver_Hs_NP_0570 93 LLDLISIPITGDTLRTFSLVLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHE 172 (351) Q Consensus 93 ls~Li~ipit~~~l~~~~viivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~ 172 (351) ...+....++. .-.+++|+|++++.++-...++|+..++.... T Consensus 81 ~~~~~~~~~~~----a~~~iiV~d~~~~~Sf~~~~~~~~~~i~~~~~--------------------------------- 123 (201) T 2q3h_A 81 FDKLRPLCYTN----TDIFLLCFSVVSPSSFQNVSEKWVPEIRCHCP--------------------------------- 123 (201) T ss_dssp CSSSGGGGGTT----CSEEEEEEETTCHHHHHHHHHTHHHHHHHHCS--------------------------------- T ss_pred HCCCCCCHHHH----HHHCCEEEECCCHHHHHHHHHHHHHHHHHHCC--------------------------------- T ss_conf 10012001001----22122112113166677899987655543067--------------------------------- Q ss_pred CCCCCCCCEEEECCEECCCCCCCHHH-------HHHHHHHHHHHHHHCCCEEEE-EECHHHHHHHHHHHHHHHH Q ss_conf 11106887799712100015887667-------899999999999860946888-5120345678999888750 Q Ver_Hs_NP_0570 173 LIDPFPVPLVIIGSKYDVFQDFESEK-------RKVICKTLRFVAHYYGASLMF-TSKSEALLLKIRGVINQLA 238 (351) Q Consensus 173 ~v~p~piPlvIVg~KYD~F~~~D~e~-------rK~i~r~LR~iAH~yGA~L~F-tSk~e~l~~r~r~~inhl~ 238 (351) .+|++|||+|.|.-.+..-.. +.+.....+.+|..+++..+| +|-... ..+..+...+. T Consensus 124 -----~~piiivgnK~D~~~~~~~~~~~~~~~~~~i~~~~~~~~~~~~~~~~~~e~Sak~~--~gI~e~f~~ii 190 (201) T 2q3h_A 124 -----KAPIILVGTQSDLREDVKVLIELDKCKEKPVPEEAAKLLAEEIKAASYIECSALTQ--KNLKEVFDAAI 190 (201) T ss_dssp -----SSCEEEEEECGGGGGCHHHHHHHHTTTCCCCCHHHHHHHHHHHTCSEEEECCTTTC--TTHHHHHHHHH T ss_pred -----CCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEEECCCC--CCHHHHHHHHH T ss_conf -----73688861147841135677776553125577899999999708953899851588--78789999999 No 61 >cd04140 ARHI_like ARHI subfamily. ARHI (A Ras homolog member I) is a member of the Ras family with several unique structural and functional properties. ARHI is expressed in normal human ovarian and breast tissue, but its expression is decreased or eliminated in breast and ovarian cancer. ARHI contains an N-terminal extension of 34 residues (human) that is required to retain its tumor suppressive activity. Unlike most other Ras family members, ARHI is maintained in the constitutively active (GTP-bound) state in resting cells and has modest GTPase activity. ARHI inhibits STAT3 (signal transducers and activators of transcription 3), a latent transcription factor whose abnormal activation plays a critical role in oncogenesis. Most Ras proteins contain a lipid modification site at the C-terminus, with a typical sequence motif CaaX, where a = an aliphatic amino acid and X = any amino acid. Lipid binding is essential for membrane attachment, a key feature of most Ras proteins. Due to Probab=99.32 E-value=8e-11 Score=91.61 Aligned_columns=157 Identities=22% Q ss_pred EEEEECCCCCHHHHHHHHCCC--CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 899865988637777755276--678887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDR--DEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r--~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |++||+.+.||||||.||+.. .+.+.||++-.| ++...-+...=-.++|..+|.-.+..|....+...+ .+ T Consensus 4 IvliGd~~VGKTsli~r~~~~~F~~~y~~ti~~~~---~~~i~~~~~~~~l~i~Dt~G~e~~~~l~~~~~~~a~----~~ 76 (165) T cd04140 4 VVVFGAGGVGKSSLVLRFVKGTFRESYIPTIEDTY---RQVISCSKNICTLQITDTTGSHQFPAMQRLSISKGH----AF 76 (165) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEECEE---EEEEEECCCEEEEEEECCCCCCCHHHHHHHHHCCCC----EE T ss_conf 89980799658999988762820665454200115---778863694899997037763102356688621898----58 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) +||.|++.+.++ +.+..|+..+++.... .+-.+|+++||+|.| T Consensus 77 ilvydit~~~Sf-~~i~~~~~~i~~~~~~----------------------------------~~~~ipiilvGNK~D-- 119 (165) T cd04140 77 ILVYSVTSKQSL-EELKPIYELICEIKGN----------------------------------NIEKIPIMLVGNKCD-- 119 (165) T ss_pred EEEEECCCHHHH-HHHHHHHHHHHHHHCC----------------------------------CCCCCEEEEEECCCC-- T ss_conf 999875997788-9999999999986224----------------------------------889857999503114-- Q ss_pred CCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHH--HHHHHHHH Q ss_conf 58876678999999999998609468885120345678--99988875 Q Ver_Hs_NP_0570 192 QDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLK--IRGVINQL 237 (351) Q Consensus 192 ~~~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r--~r~~inhl 237 (351) ....|.+--.-.+.+|-.+|+..+.+|-+...... ++.++|-+ T Consensus 120 ---l~~~r~V~~~e~~~~a~~~~~~~~E~SAk~~~nv~~~F~~l~~l~ 164 (165) T cd04140 120 ---ESHKREVSSNEGAACATEWNCAFMETSAKTNHNVQELFQELLNLE 164 (165) T ss_pred ---CCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHC T ss_conf ---010466898999999995699589997148988789999999851 No 62 >cd04152 Arl4_Arl7 Arl4/Arl7 subfamily. Arl4 (Arf-like 4) is highly expressed in testicular germ cells, and is found in the nucleus and nucleolus. In mice, Arl4 is developmentally expressed during embryogenesis, and a role in somite formation and central nervous system differentiation has been proposed. Arl7 has been identified as the only Arf/Arl protein to be induced by agonists of liver X-receptor and retinoid X-receptor and by cholesterol loading in human macrophages. Arl7 is proposed to play a role in transport between a perinuclear compartment and the plasma membrane, apparently linked to the ABCA1-mediated cholesterol secretion pathway. Older literature suggests that Arl6 is a part of the Arl4/Arl7 subfamily, but analyses based on more recent sequence data place Arl6 in its own subfamily. Probab=99.32 E-value=2e-10 Score=89.08 Aligned_columns=160 Identities=19% Q ss_pred EEEEEECCCCCHHHHHHHHC-CCCCCCCCCCCCCHHHHHHHCCCCCCCEE-EEEEEECCCCCHHHCEEEEECCCCCCEEE Q ss_conf 58998659886377777552-76678887531000221110157871117-88897157854202110000423512067 Q Ver_Hs_NP_0570 33 FVFFIGSKNGGKTTIILRCL-DRDEPPKPTLALEYTYGRRAKGHNTPKDI-AHFWELGGGTSLLDLISIPITGDTLRTFS 110 (351) Q Consensus 33 ~v~~vGsk~~GKTTli~Rfl-~r~e~~KPTlALeYtygRra~~~~~~Kdv-aH~WELGgg~~ls~Li~ipit~~~l~~~~ 110 (351) .|+++|..++|||||++|+. +......||.+..+..-.-..+++ ++| .++|++||.-.+-.|...-.+. .-. T Consensus 5 kIvilG~~~~GKTsil~r~~~~~~~~~~pT~g~~~~~~~~~~~~~--~~v~l~iwD~aGqe~~r~l~~~yy~~----a~g 78 (183) T cd04152 5 HIVMLGLDSAGKTTVLYRLKFNEFVNTVPTKGFNTEKIKVSLGNS--KGITFHFWDVGGQEKLRPLWKSYTRC----TDG 78 (183) T ss_pred EEEEEECCCCCHHHHHHHHHCCCCCCEECCEEEEEEEEEEEECCC--CEEEEEEEECCCCHHHHHHHHHHCCC----CCE T ss_conf 999985089868998887644821110022033478898750477--42799998648850256755311368----867 Q ss_pred EEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECC Q ss_conf 78887369846899999999999999999999998526953789999999984146677600111068877997121000 Q Ver_Hs_NP_0570 111 LVLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDV 190 (351) Q Consensus 111 viivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~ 190 (351) +|+|+|.|...++=...++| +++.+.....+ +|++|+|+|.|. T Consensus 79 iI~V~D~sd~~~~~~~~~~l--------~~i~~~~~~~~-----------------------------~piLi~~NK~Dl 121 (183) T cd04152 79 IVFVVDSVDVERMEEAKTEL--------HKITRFSENQG-----------------------------VPVLVLANKQDL 121 (183) T ss_pred EEEEEECCCHHHHHHHHHHH--------HHHHHCCCCCC-----------------------------CEEEEEECCCCC T ss_conf 99998537834689999999--------99971126789-----------------------------789999616787 Q ss_pred CCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHH Q ss_conf 158876678999999999998609468885120345678999888750 Q Ver_Hs_NP_0570 191 FQDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLA 238 (351) Q Consensus 191 F~~~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r~r~~inhl~ 238 (351) -.....+...-.. .|+-++..++..+.-+|-... ..+...+..|+ T Consensus 122 ~~~~~~~e~~~~~-~l~~~~~~~~~~~~~~SA~tG--~Gi~e~f~~L~ 166 (183) T cd04152 122 PNALSVSEVEKLL-ALHELSASTPWHVQPACAIIG--EGLQEGLEKLY 166 (183) T ss_pred CCCCCHHHHHHHH-HHHHHHHCCCCEEEEEECCCC--CCHHHHHHHHH T ss_conf 6467889999998-889998518967987404678--78889999999 No 63 >cd04137 RheB Rheb (Ras Homolog Enriched in Brain) subfamily. Rheb was initially identified in rat brain, where its expression is elevated by seizures or by long-term potentiation. It is expressed ubiquitously, with elevated levels in muscle and brain. Rheb functions as an important mediator between the tuberous sclerosis complex proteins, TSC1 and TSC2, and the mammalian target of rapamycin (TOR) kinase to stimulate cell growth. TOR kinase regulates cell growth by controlling nutrient availability, growth factors, and the energy status of the cell. TSC1 and TSC2 form a dimeric complex that has tumor suppressor activity, and TSC2 is a GTPase activating protein (GAP) for Rheb. The TSC1/TSC2 complex inhibits the activation of TOR kinase through Rheb. Rheb has also been shown to induce the formation of large cytoplasmic vacuoles in a process that is dependent on the GTPase cycle of Rheb, but independent of the TOR kinase, suggesting Rheb plays a role in endocytic trafficking that le Probab=99.32 E-value=7e-11 Score=91.98 Aligned_columns=156 Identities=21% Q ss_pred CEEEEEECCCCCHHHHHHHHCCC--CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEE Q ss_conf 45899865988637777755276--6788875310002211101578711178889715785420211000042351206 Q Ver_Hs_NP_0570 32 KFVFFIGSKNGGKTTIILRCLDR--DEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTF 109 (351) Q Consensus 32 k~v~~vGsk~~GKTTli~Rfl~r--~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~ 109 (351) +-|++||+.|.|||||+.||+.. .+.+.||++-+| .+..--+...=-..+|..+|--.+..|...-.+.-+ T Consensus 2 ~KIvliGd~~VGKTsli~rf~~~~f~~~y~~Ti~~~~---~k~i~v~~~~~~l~iwDtaGqe~~~~l~~~~~~~a~---- 74 (180) T cd04137 2 RKIAVLGSRSVGKSSLTVQFVEGHFVESYYPTIENTF---SKIIRYKGQDYHLEIVDTAGQDEYSILPQKYSIGIH---- 74 (180) T ss_pred EEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCEECCC---CCCEEECCEEEEEEECCCCCCCCCHHHHHHHCCCCC---- T ss_conf 0789970798438999999861800776466100031---200356682689987478873200023366504887---- Q ss_pred EEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEEC Q ss_conf 77888736984689999999999999999999999852695378999999998414667760011106887799712100 Q Ver_Hs_NP_0570 110 SLVLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYD 189 (351) Q Consensus 110 ~viivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD 189 (351) .++||+|++.+.++ +.++.|++.+.+.... -.+|++|||+|.| T Consensus 75 ~~ilvfdit~~~Sf-~~i~~~~~~i~~~~~~------------------------------------~~ipiiLvGNK~D 117 (180) T cd04137 75 GYILVYSVTSRKSF-EVVKVIYDKILDMLGK------------------------------------ESVPIVLVGNKSD 117 (180) T ss_pred EEEEEEECCCHHHH-HHHHHHHHHHHHHHCC------------------------------------CCCEEEEEEECCC T ss_conf 38998544897678-9999999999986189------------------------------------9848999420168 Q ss_pred CCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHH Q ss_conf 0158876678999999999998609468885120345678999888750 Q Ver_Hs_NP_0570 190 VFQDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLA 238 (351) Q Consensus 190 ~F~~~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r~r~~inhl~ 238 (351) + +..|.+--.-..-+|..+|+..+.+|-+.. ..+..+...++ T Consensus 118 l-----~~~r~V~~~e~~~~a~~~~~~~~E~SAk~~--~nV~e~F~~l~ 159 (180) T cd04137 118 L-----HTQRQVSTEEGKELAESWGAAFLESSAREN--ENVEEAFELLI 159 (180) T ss_pred C-----CCCCCCCHHHHHHHHHHCCCCEEEEECCCC--CCHHHHHHHHH T ss_conf 5-----123657989999999965997899861579--88889999999 No 64 >cd04139 RalA_RalB RalA/RalB subfamily. The Ral (Ras-like) subfamily consists of the highly homologous RalA and RalB. Ral proteins are believed to play a crucial role in tumorigenesis, metastasis, endocytosis, and actin cytoskeleton dynamics. Despite their high sequence similarity (80% sequence identity), nonoverlapping and opposing functions have been assigned to RalA and RalBs in tumor migration. In human bladder and prostate cancer cells, RalB promotes migration while RalA inhibits it. A Ral-specific set of GEFs has been identified that are activated by Ras binding. This RalGEF activity is enhanced by Ras binding to another of its target proteins, phosphatidylinositol 3-kinase (PI3K). Ral effectors include RLIP76/RalBP1, a Rac/cdc42 GAP, and the exocyst (Sec6/8) complex, a heterooctomeric protein complex that is involved in tethering vesicles to specific sites on the plasma membrane prior to exocytosis. In rat kidney cells, RalB is required for functional assembly of the exo Probab=99.32 E-value=7.5e-11 Score=91.80 Aligned_columns=154 Identities=21% Q ss_pred EEEEECCCCCHHHHHHHHCCC--CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 899865988637777755276--678887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDR--DEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r--~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |++||+.|.||||||.||+.. .+.+.||++..|+---.-++... -.++|..+|...+..|...-++... .+ T Consensus 3 ivliGd~~VGKTsli~r~~~~~f~~~~~~Ti~~~~~~~i~~~~~~v---~l~iwDt~Gqe~~~~l~~~~~~~a~----~~ 75 (164) T cd04139 3 VIVVGAGGVGKSALTLQFMYDEFVEDYEPTKADSYRKKVVLDGEDV---QLNILDTAGQEDYAAIRDNYHRSGE----GF 75 (164) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEECCCEE---EEEEEECCCCHHHHHHHHHHCCCCC----EE T ss_conf 8998179854899999987182076544322321468998859389---9998427887135788887525898----79 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) +||.|++.+.++ +.+..|...+.++.+ +-.+|++|||+|.|+ T Consensus 76 ilvydit~~~Sf-~~i~~~~~~~~~~~~------------------------------------~~~ip~ilvGNK~Dl- 117 (164) T cd04139 76 LLVFSITDMESF-TATAEFREQILRVKD------------------------------------DDNVPLLLVGNKCDL- 117 (164) T ss_pred EEEEECCCHHHH-HHHHHHHHHHHHHHC------------------------------------CCCCEEEEECCCHHH- T ss_conf 999752885578-899999999998617------------------------------------997279997240132- Q ss_pred CCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHH Q ss_conf 58876678999999999998609468885120345678999888750 Q Ver_Hs_NP_0570 192 QDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLA 238 (351) Q Consensus 192 ~~~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r~r~~inhl~ 238 (351) .++|.+...-.+.+|..+|+..+.+|-+.. .++..+..+++ T Consensus 118 ----~~~r~v~~~e~~~~a~~~~~~~~E~SAk~g--~ni~e~F~~l~ 158 (164) T cd04139 118 ----EDKRQVSSEEAANLARQWGVPYVETSAKTR--QNVEKAFYDLV 158 (164) T ss_pred ----HHHCCCCHHHHHHHHHHCCCCEEEEECCCC--CCHHHHHHHHH T ss_conf ----231167489999999965995999971589--88789999999 No 65 >e2a5ja1 c.37.1.8 (A:9-181) Rab2b {Human (Homo sapiens) [TaxID:9606]} SCOP: u1z0aa1 u1z0ad_ u1z0ab_ Probab=99.32 E-value=1.1e-10 Score=90.77 Aligned_columns=154 Identities=21% Q ss_pred EEEEECCCCCHHHHHHHHCCCC--CCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 8998659886377777552766--78887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDRD--EPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r~--e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |++||+.|+||||||+|++... +...||.+.++...-....+... ..++|..+|......+...-+.... ++ T Consensus 6 V~ivG~~~vGKTsLi~~~~~~~~~~~~~~t~~~~~~~~~~~~~~~~~--~l~i~d~~g~~~~~~~~~~~~~~~d----~~ 79 (173) T e2a5ja1 6 YIIIGDTGVGKSCLLLQFTDKRFQPVHDLTIGVEFGARMVNIDGKQI--KLQIWDTAGQESFRSITRSYYRGAA----GA 79 (173) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEECCCCCCEECCCEE--EEEEEECCCCCCCCCHHHHHHCCCC----EE T ss_conf 99983699779999999864834666341355200101110158527--9998614785311000055504897----68 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) ++|+|++.+.++ +.+..|+..+...-.+ ..|+++||+|.|.. T Consensus 80 i~v~d~~~~~s~-~~~~~~~~~i~~~~~~-------------------------------------~~p~iivgnK~Dl~ 121 (173) T e2a5ja1 80 LLVYDITRRETF-NHLTSWLEDARQHSSS-------------------------------------NMVIMLIGNKSDLE 121 (173) T ss_pred EEEEECCCHHHH-HHHHHHHHHHHHHCCC-------------------------------------CCEEEEEECCCCCH T ss_conf 999742651467-8988889998852167-------------------------------------61232210112441 Q ss_pred CCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHH Q ss_conf 58876678999999999998609468885120345678999888750 Q Ver_Hs_NP_0570 192 QDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLA 238 (351) Q Consensus 192 ~~~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r~r~~inhl~ 238 (351) +.+++...-++.+|-.+|...+.+|-+.. ..+..+..+++ T Consensus 122 -----~~~~v~~~~~~~~~~~~~~~~~e~Saktg--~gv~e~F~~l~ 161 (173) T e2a5ja1 122 -----SRRDVKREEGEAFAREHGLIFMETSAKTA--CNVEEAFINTA 161 (173) T ss_pred -----HHCCCCHHHHHHHHHHCCCEEEEEECCCC--CCHHHHHHHHH T ss_conf -----01032088999999964984999851689--88889999999 No 66 >cd04101 RabL4 RabL4 (Rab-like4) subfamily. RabL4s are novel proteins that have high sequence similarity with Rab family members, but display features that are distinct from Rabs, and have been termed Rab-like. As in other Rab-like proteins, RabL4 lacks a prenylation site at the C-terminus. The specific function of RabL4 remains unknown. Probab=99.32 E-value=4.2e-11 Score=93.41 Aligned_columns=154 Identities=17% Q ss_pred EEEEECCCCCHHHHHHHHCCC----CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEE Q ss_conf 899865988637777755276----6788875310002211101578711178889715785420211000042351206 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDR----DEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTF 109 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r----~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~ 109 (351) |++||+.|.|||||++||++. .+.+.||++.||..-.-. -++...--..+|..+|...+..+...-++ ..- T Consensus 3 vv~iGd~~VGKTsli~~~~~~~~~f~~~y~~T~~~~~~~~~~~-i~~~~~~~l~i~DtaGqe~~~~~~~~~~~----~a~ 77 (164) T cd04101 3 CAVVGDPAVGKTAFVQMFHSNGAVFPKNYLMTTGCDFVVKEVP-VDTDNTVELFIFDSAGQELYSDMVSNYWE----SPS 77 (164) T ss_pred EEEEECCCCCHHHHHHHHHHCCCEECCCCCCCEEEEEEEEEEE-ECCCCEEEEEEEECCCCHHHHHHHHHHCC----CCC T ss_conf 8998079821898888776168441666543112456799999-77996799999603872246788787424----997 Q ss_pred EEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEEC Q ss_conf 77888736984689999999999999999999999852695378999999998414667760011106887799712100 Q Ver_Hs_NP_0570 110 SLVLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYD 189 (351) Q Consensus 110 ~viivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD 189 (351) .++||.|++.+.++ +.+..|+..++..-.. +|++|||+|+| T Consensus 78 ~~ilvydit~~~Sf-~~i~~w~~~i~~~~~~--------------------------------------~p~ilVGNK~D 118 (164) T cd04101 78 VFILVYDVSNKASF-ENCSRWVNKVRTASKH--------------------------------------MPGVLVGNKMD 118 (164) T ss_pred EEEEEEECCCHHHH-HHHHHHHHHHHHHCCC--------------------------------------CEEEEEECCCC T ss_conf 69999417997689-9999999999984499--------------------------------------73999821434 Q ss_pred CCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHH Q ss_conf 0158876678999999999998609468885120345678999888750 Q Ver_Hs_NP_0570 190 VFQDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLA 238 (351) Q Consensus 190 ~F~~~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r~r~~inhl~ 238 (351) + .++|++--.--+.+|-.+|+..+.+|-++. .++..+...++ T Consensus 119 L-----~~~r~V~~~~~~~~a~~~~~~~~e~SAktg--~nV~e~F~~la 160 (164) T cd04101 119 L-----ADKAEVTDAQAQAFAQANQLKFFKTSALRG--VGYEEPFESLA 160 (164) T ss_pred C-----CCCCCCCHHHHHHHHHHCCCCEEEEECCCC--CCHHHHHHHHH T ss_conf 0-----011678989999999963994999971689--88789999999 No 67 >2dpx_A GTP-binding protein RAD; GTPase, small-G, RGK, signal transduction, diabetes; HET: GDP; 1.80A {Homo sapiens} Probab=99.32 E-value=3.6e-11 Score=93.85 Aligned_columns=155 Identities=16% Q ss_pred EEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEEEE Q ss_conf 89986598863777775527667888753100022111015787111788897157854202110000423512067788 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDRDEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSLVL 113 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~vii 113 (351) |+++|..++||||||+|+......+.+++..++ -.+....+..+-..++|+.+|...+..+....+.... .+++ T Consensus 10 I~viG~~~~GKTsli~~l~~~~~~~~~~~~~~~--~~~~i~~~~~~~~l~i~D~~g~~~~~~~~~~~~~~~d----~~i~ 83 (174) T 2dpx_A 10 VLLLGAPGVGKSALARIFGGVEDGPEAEAAGHT--YDRSIVVDGEEASLMVYDIWEQDGGRWLPGHCMAMGD----AYVI 83 (174) T ss_dssp EEEECCTTSSHHHHHHHHHTCC---------CE--EEEEEEETTEEEEEEEECC-------CCHHHHHTSCS----EEEE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCEEEEE--EEEEEEECCEEEEEEEEECCCCCCCHHHHHHHHHCCH----HHHH T ss_conf 999807998799999998456366412304764--5542366040134777621000100111111110100----0000 Q ss_pred EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCCCC Q ss_conf 87369846899999999999999999999998526953789999999984146677600111068877997121000158 Q Ver_Hs_NP_0570 114 VLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVFQD 193 (351) Q Consensus 114 vlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F~~ 193 (351) |+|++.|.++ +.++.|+..+.+.... ..+|+++||+|+|..+. T Consensus 84 v~d~~~~~s~-~~~~~~~~~i~~~~~~------------------------------------~~~piiiv~nK~Dl~~~ 126 (174) T 2dpx_A 84 VYSVTDKGSF-EKASELRVQLRRARQT------------------------------------DDVPIILVGNKSDLVRS 126 (174) T ss_dssp EEETTCHHHH-HHHHHHHHHHHHHC---------------------------------------CCCEEEEEECTTCCTT T ss_pred EECCCCCCCC-CCCCHHHHHHHHCCCC------------------------------------CCEEEEEEHHCCCHHHH T ss_conf 0002123420-1000012343210112------------------------------------42020100111221231 Q ss_pred CCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHH Q ss_conf 876678999999999998609468885120345678999888750 Q Ver_Hs_NP_0570 194 FESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLA 238 (351) Q Consensus 194 ~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r~r~~inhl~ 238 (351) +.+...-.+-+|..+|+..+.+|-+.. ..+..+...++ T Consensus 127 -----~~v~~~e~~~~~~~~~~~~~~~Sak~~--~~i~~~f~~l~ 164 (174) T 2dpx_A 127 -----REVSVDEGRACAVVFDCKFIETSAALH--HNVQALFEGVV 164 (174) T ss_dssp -----CCSCHHHHHHHHHHHTSEEEECBTTTT--BTHHHHHHHHH T ss_pred -----CCCCHHHHHHHHHHCCCEEEEEECCCC--CCHHHHHHHHH T ss_conf -----155278888899865971899861689--78889999999 No 68 >d2ngra_ c.37.1.8 (A:) CDC42 {Human (Homo sapiens)} Probab=99.31 E-value=6.3e-11 Score=92.28 Aligned_columns=168 Identities=17% Q ss_pred EEEEECCCCCHHHHHHHHCCC--CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 899865988637777755276--678887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDR--DEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r--~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |+++|+.++|||||++||+.+ .+.+.||++..|+.--..++..- ..++|+.+|-.....+....++..++ + T Consensus 6 i~iiG~~~vGKSsli~~~~~~~f~~~~~~t~~~~~~~~~~~~~~~i---~~~i~D~~g~~~~~~~~~~~~~~~~~----~ 78 (191) T d2ngra_ 6 CVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPY---TLGLFDTAGQEDYDRLRPLSYPQTDV----F 78 (191) T ss_dssp EEEEESTTSSHHHHHHHHHHSCCCSSCCCCSEEEEEEEEEETTEEE---EEEEEEECCSGGGTTTGGGGCTTCSE----E T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEECCEEE---EEEEECCCCCCHHHHHHHHHCCCCEE----E T ss_conf 9998079977899999987185466535520233577876266479---99973146762144664542055278----9 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) ++|.|++.+.++=.-.++|+..++.... .+|+++||+|+|.. T Consensus 79 ilv~d~~~~~Sf~~~~~~~~~~~~~~~~--------------------------------------~ipiilvgnK~Dl~ 120 (191) T d2ngra_ 79 LVCFSVVSPSSFENVKEKWVPEITHHCP--------------------------------------KTPFLLVGTQIDLR 120 (191) T ss_dssp EEEEETTCHHHHHHHHHTHHHHHHHHCT--------------------------------------TCCEEEEEECGGGG T ss_pred EEEEECCCHHHHHHHHHHHHHHHHHCCC--------------------------------------CCEEEEEECCCCCC T ss_conf 9987146855899988877888752378--------------------------------------74389974052433 Q ss_pred CC-------CCHHHHHHHHHHHHHHHHHCCCEEEE-EECHHHHHHH--HHHHHHHHHCCCCCCCE Q ss_conf 58-------87667899999999999860946888-5120345678--99988875057777730 Q Ver_Hs_NP_0570 192 QD-------FESEKRKVICKTLRFVAHYYGASLMF-TSKSEALLLK--IRGVINQLAFGIDKSKS 246 (351) Q Consensus 192 ~~-------~D~e~rK~i~r~LR~iAH~yGA~L~F-tSk~e~l~~r--~r~~inhl~FG~~~~k~ 246 (351) .+ .....|.+--.-..-+|..+++.-+| +|-...-... +..+|...+-...+.++ T Consensus 121 ~~~~~~~~~~~~~~r~v~~~~~~~~a~~~~~~~~~E~SA~tg~gI~e~f~~~i~~~l~~~~~~~~ 185 (191) T d2ngra_ 121 DDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQKGLKNVFDEAILAALEPPEPKKS 185 (191) T ss_dssp GCHHHHHHHHTTTCCCCCHHHHHHHHHHTTCSCEEECCTTTCTTHHHHHHHHHHHHTSCCSTTCC T ss_pred CCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCC T ss_conf 22026788874046776778999999980897089986047877789999999998547788877 No 69 >e2atxa1 c.37.1.8 (A:9-193) RhoQ {Human (Homo sapiens) [TaxID:9606]} SCOP: u2atxb_ Probab=99.31 E-value=4.8e-11 Score=93.01 Aligned_columns=158 Identities=18% Q ss_pred EEEEECCCCCHHHHHHHHCCCC--CCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 8998659886377777552766--78887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDRD--EPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r~--e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |+++|+.|+|||||++||+... +.+.||+.-.| .+........-..++|+.+|-.....+....++... .+ T Consensus 12 i~viG~~~vGKTsli~~~~~~~~~~~~~~t~~~~~---~~~i~~~~~~~~l~i~D~~g~~~~~~~~~~~~~~~d----~~ 84 (185) T e2atxa1 12 CVVVGDGAVGKTCLLMSYANDAFPEEYVPTVFDHY---AVSVTVGGKQYLLGLYDTAGQEDYDRLRPLSYPMTD----VF 84 (185) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEE---EEEEEECCCEEEEEEEECCCCCHHHHHHHHHCCCCE----EE T ss_conf 99980699889999999863832676355168888---899987396489998505573112333454314342----56 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) ++|+|++.|+++=.-.++|...++.+... +|++|||+|+|+. T Consensus 85 i~v~D~~~~~S~~~~~~~~~~~~~~~~~~--------------------------------------~piiivgnK~Dl~ 126 (185) T e2atxa1 85 LICFSVVNPASFQNVKEEWVPELKEYAPN--------------------------------------VPFLLIGTQIDLR 126 (185) T ss_pred EEEEECCCCCHHHHHHHHHHHHHHHHCCC--------------------------------------CEEEEEEECCCCC T ss_conf 78874357402788778889999860797--------------------------------------0799997235876 Q ss_pred CC-------CCHHHHHHHHHHHHHHHHHCCCEEEE-EECHHHHHHHHHHHHHHHH Q ss_conf 58-------87667899999999999860946888-5120345678999888750 Q Ver_Hs_NP_0570 192 QD-------FESEKRKVICKTLRFVAHYYGASLMF-TSKSEALLLKIRGVINQLA 238 (351) Q Consensus 192 ~~-------~D~e~rK~i~r~LR~iAH~yGA~L~F-tSk~e~l~~r~r~~inhl~ 238 (351) .+ .+...|.+...-.+.+|..+|+-.+| +|-... ..+..+...+. T Consensus 127 ~~~~~~~~~~~~~~~~v~~~~~~~~a~~~~~~~~~e~Sa~t~--~gi~e~fe~~i 179 (185) T e2atxa1 127 DDPKTLARLNDMKEKPICVEQGQKLAKEIGACCYVECSALTQ--KGLKTVFDEAI 179 (185) T ss_pred CCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEEEEEECCCC--CCHHHHHHHHH T ss_conf 512466655441146678899999999708913788750578--78789999999 No 70 >2fg5_A RAB-22B, RAS-related protein RAB-31; G-protein, GTP analogue, structural genomics, structural genomics consortium, SGC; HET: GNP; 2.80A {Homo sapiens} SCOP: c.37.1.8 Probab=99.31 E-value=4.9e-11 Score=92.96 Aligned_columns=154 Identities=24% Q ss_pred EEEEECCCCCHHHHHHHHCCC--CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 899865988637777755276--678887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDR--DEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r--~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |.+||..|+||||||+||+.. .+.+.||++.+|........+... ...+|..+|......+...-+. ..-.+ T Consensus 26 I~iiG~~~vGKSsLi~~l~~~~~~~~~~~T~~~~~~~~~~~~~~~~~--~~~i~d~~~~~~~~~~~~~~~~----~~~~~ 99 (192) T 2fg5_A 26 VCLLGDTGVGKSSIVCRFVQDHFDHNISPTIGASFMTKTVPCGNELH--KFLIWDTAGQERFHSLAPMYYR----GSAAA 99 (192) T ss_dssp EEEEECTTSSHHHHHHHHHHCCCCTTCCCCSSEEEEEEEEECSSSEE--EEEEEEECCSGGGGGGTHHHHT----TCSEE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEECCCCEEE--EEECCCCCHHHHHHHHHHHHHH----HHHHE T ss_conf 99980699768999999872810677676223345666410465011--1000001002355678888763----11100 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) ++|+|++.++.+ ..+..|+..+++.... .+|+++||+|.|. T Consensus 100 i~v~d~~~~~s~-~~i~~~~~~i~~~~~~-------------------------------------~~~iilVgnK~Dl- 140 (192) T 2fg5_A 100 VIVYDITKQDSF-YTLKKWVKELKEHGPE-------------------------------------NIVMAIAGNKCDL- 140 (192) T ss_dssp EEEEETTCTHHH-HHHHHHHHHHHHHSCT-------------------------------------TCEEEEEEECGGG- T ss_pred EEEECCCCHHHH-HHHHHHHHHHHHHCCC-------------------------------------CCEEEEEECCCCH- T ss_conf 122103440568-9999999999872589-------------------------------------7068885052200- Q ss_pred CCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHH Q ss_conf 58876678999999999998609468885120345678999888750 Q Ver_Hs_NP_0570 192 QDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLA 238 (351) Q Consensus 192 ~~~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r~r~~inhl~ 238 (351) .+.+..+..-++.+|-.+++.++.+|-.+. ..+..+...++ T Consensus 141 ----~~~~~~~~~~~~~~~k~~~~~~~evSak~g--~gV~elf~~i~ 181 (192) T 2fg5_A 141 ----SDIREVPLKDAKEYAESIGAIVVETSAKNA--INIEELFQGIS 181 (192) T ss_dssp ----GGGCCSCHHHHHHHHHTTTCEEEECBTTTT--BSHHHHHHHHH T ss_pred ----HHHCCCCHHHHHHHHHHCCCEEEEEECCCC--CCHHHHHHHHH T ss_conf ----011045478999999963985999852689--78889999999 No 71 >2j0v_A RAC-like GTP-binding protein ARAC7; ROP9, atrac7, membrane, palmitate, RHO GTPase, abscisic acid signaling pathway; HET: GDP; 1.78A {Arabidopsis thaliana} Probab=99.31 E-value=2.7e-11 Score=94.61 Aligned_columns=158 Identities=17% Q ss_pred EEEEECCCCCHHHHHHHHCCC--CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 899865988637777755276--678887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDR--DEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r--~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |+|+|+.++||||||+||... .+.+.||++.+| .+.--.+...-..++|+.+|......+....++.-+. + T Consensus 12 i~iiG~~~vGKTsli~~~~~~~~~~~~~~t~~~~~---~~~~~~~~~~~~l~i~d~~g~~~~~~~~~~~~~~ad~----~ 84 (212) T 2j0v_A 12 CVTVGDGAVGKTCMLICYTSNKFPTDYIPTVFDNF---SANVAVDGQIVNLGLWDTAGQEDYSRLRPLSYRGADI----F 84 (212) T ss_dssp EEEEESTTSSHHHHHHHHHHSCCCSSCCCSSCCCE---EEEEECSSCEEEEEEECCCCCCCCC--CCGGGTTCSE----E T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEE---EEEEEECCEEEEEEECCCCCCCCCHHHHHCCCCHHHC----C T ss_conf 99980799778999999863832666355126778---8876644556653101256742000111000101101----3 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) ++|+|++.+.++=..+.+|++.++..... +|++|||+|.|+- T Consensus 85 i~v~d~~~~~s~~~~~~~~~~~~~~~~~~--------------------------------------~piiivgNK~Dl~ 126 (212) T 2j0v_A 85 VLAFSLISKASYENVLKKWMPELRRFAPN--------------------------------------VPIVLVGTKLDLR 126 (212) T ss_dssp EEEEETTCHHHHHHHHHTHHHHHHHHCTT--------------------------------------CCEEEEEECHHHH T ss_pred CCCCCCCCHHHHHHHHHHHHHHHHHHHCC--------------------------------------CEEEEEECCCCCC T ss_conf 34432034233899999989998764068--------------------------------------4389985056730 Q ss_pred CCCC---HHHHHHHHHHHHHHHHHCCCEEEE-EECHHHHHHHHHHHHHHHH Q ss_conf 5887---667899999999999860946888-5120345678999888750 Q Ver_Hs_NP_0570 192 QDFE---SEKRKVICKTLRFVAHYYGASLMF-TSKSEALLLKIRGVINQLA 238 (351) Q Consensus 192 ~~~D---~e~rK~i~r~LR~iAH~yGA~L~F-tSk~e~l~~r~r~~inhl~ 238 (351) .+.. .+.+.+...-..-+|..+|...+| +|-... ..+..++..++ T Consensus 127 ~~~~~~~~~~~~v~~~e~~~~a~~~~~~~~~e~Sak~~--~~I~~lf~~i~ 175 (212) T 2j0v_A 127 DDKGYLADHTNVITSTQGEELRKQIGAAAYIECSSKTQ--QNVKAVFDTAI 175 (212) T ss_dssp TCHHHHHTCSSCCCHHHHHHHHHHHTCSEEEECCTTTC--TTHHHHHHHHH T ss_pred CCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC--CCHHHHHHHHH T ss_conf 01122345553110888999999841885698850578--68889999999 No 72 >cd04133 Rop_like Rop subfamily. The Rop (Rho-related protein from plants) subfamily plays a role in diverse cellular processes, including cytoskeletal organization, pollen and vegetative cell growth, hormone responses, stress responses, and pathogen resistance. Rops are able to regulate several downstream pathways to amplify a specific signal by acting as master switches early in the signaling cascade. They transmit a variety of extracellular and intracellular signals. Rops are involved in establishing cell polarity in root-hair development, root-hair elongation, pollen-tube growth, cell-shape formation, responses to hormones such as abscisic acid (ABA) and auxin, responses to abiotic stresses such as oxygen deprivation, and disease resistance and disease susceptibility. An individual Rop can have a unique function or an overlapping function shared with other Rop proteins; in addition, a given Rop-regulated function can be controlled by one or multiple Rop proteins. For example, Probab=99.31 E-value=3.4e-11 Score=94.01 Aligned_columns=158 Identities=17% Q ss_pred EEEEECCCCCHHHHHHHHCCC--CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 899865988637777755276--678887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDR--DEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r--~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |++||+.+.|||||+.||.+. .+.+.||++-+|+.--..+++.- ..++|.-+|.-.+..|...-++ ..-.+ T Consensus 4 iv~iGd~~VGKTsLi~rf~~~~F~~~~~pTi~~~~~~~i~~~~~~v---~l~IwDTaGqe~~~~l~~~~~r----~a~~~ 76 (176) T cd04133 4 CVTVGDGAVGKTCMLICYTSNKFPTDYIPTVFDNFSANVSVDGNTV---NLGLWDTAGQEDYNRLRPLSYR----GADVF 76 (176) T ss_pred EEEECCCCCCHHHHHHHHHCCEECCCCCCEEEEEEEEEEEECCEEE---EEEEEECCCCHHHHHHHHHHCC----CCCEE T ss_conf 9997179844899888875380168635335311136788889489---9998756887146788887411----44726 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) +||.|++.+.++-.-++.|+..+++.... +|++|||+|.|+= T Consensus 77 ilvydvt~~~Sf~~~~~~w~~~~~~~~~~--------------------------------------~piiLVGNK~DL~ 118 (176) T cd04133 77 VLAFSLISRASYENVLKKWVPELRHYAPN--------------------------------------VPIVLVGTKLDLR 118 (176) T ss_pred EEEEECCCCHHHHHHHHHHHHHHHHHCCC--------------------------------------CEEEEEECCCCCH T ss_conf 99974487220799999989999972799--------------------------------------4899970575511 Q ss_pred CCCC-----HHHHHHHHHHHHHHHHHCCCEEEE-EECHHHHHHHHHHHHHHHH Q ss_conf 5887-----667899999999999860946888-5120345678999888750 Q Ver_Hs_NP_0570 192 QDFE-----SEKRKVICKTLRFVAHYYGASLMF-TSKSEALLLKIRGVINQLA 238 (351) Q Consensus 192 ~~~D-----~e~rK~i~r~LR~iAH~yGA~L~F-tSk~e~l~~r~r~~inhl~ 238 (351) ++-. ++.+-+...--.-+|..+|+.++| +|-+.. .++..+-..++ T Consensus 119 ~~r~~~~~~~~~~~v~~~e~~~~a~~~~~~~y~EtSAktg--~nV~e~F~~~~ 169 (176) T cd04133 119 DDKQYLADHPGASPITTAQGEELRKQIGAAAYIECSSKTQ--QNVKAVFDAAI 169 (176) T ss_pred HHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEECCCC--CCHHHHHHHHH T ss_conf 1245665301335436789999999639974899751378--78789999999 No 73 >cd01870 RhoA_like RhoA-like subfamily. The RhoA subfamily consists of RhoA, RhoB, and RhoC. RhoA promotes the formation of stress fibers and focal adhesions, regulating cell shape, attachment, and motility. RhoA can bind to multiple effector proteins, thereby triggering different downstream responses. In many cell types, RhoA mediates local assembly of the contractile ring, which is necessary for cytokinesis. RhoA is vital for muscle contraction; in vascular smooth muscle cells, RhoA plays a key role in cell contraction, differentiation, migration, and proliferation. RhoA activities appear to be elaborately regulated in a time- and space-dependent manner to control cytoskeletal changes. Most Rho proteins contain a lipid modification site at the C-terminus, with a typical sequence motif CaaX, where a = an aliphatic amino acid and X = any amino acid. Lipid binding is essential for membrane attachment, a key feature of most Rho proteins. RhoA and RhoC are observed only in geranyl Probab=99.31 E-value=3.5e-11 Score=93.89 Aligned_columns=158 Identities=22% Q ss_pred EEEEECCCCCHHHHHHHHCCC--CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 899865988637777755276--678887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDR--DEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r--~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |++||+.|.|||||+.||... .+.+.||+.-+|+.--..++... ..++|..+|--.+..|...-.+..+ .+ T Consensus 4 iiliGd~~VGKTsli~r~~~~~F~~~~~pTi~~~~~~~i~i~~~~v---~l~iwDtaGqe~~~~l~~~~~~~a~----~~ 76 (175) T cd01870 4 LVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYVADIEVDGKQV---ELALWDTAGQEDYDRLRPLSYPDTD----VI 76 (175) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEECCEEE---EEEEECCCCHHHHHHHHHHHHCCCC----EE T ss_conf 8998269843899999986382366525402213689998989699---9987058620246677787504898----48 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) +||.|++.+.++=.-.++|+..+++.... +|+++||+|+|+- T Consensus 77 ilvydi~~~~Sf~~i~~~W~~~~~~~~~~--------------------------------------~piiLvgnK~DL~ 118 (175) T cd01870 77 LMCFSIDSPDSLENIPEKWTPEVKHFCPN--------------------------------------VPIILVGNKKDLR 118 (175) T ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHCCC--------------------------------------CEEEEEECCCCCC T ss_conf 99976686557899999889999972589--------------------------------------5299985154433 Q ss_pred CCCC-------HHHHHHHHHHHHHHHHHCCCEEEE-EECHHHHHHHHHHHHHHHH Q ss_conf 5887-------667899999999999860946888-5120345678999888750 Q Ver_Hs_NP_0570 192 QDFE-------SEKRKVICKTLRFVAHYYGASLMF-TSKSEALLLKIRGVINQLA 238 (351) Q Consensus 192 ~~~D-------~e~rK~i~r~LR~iAH~yGA~L~F-tSk~e~l~~r~r~~inhl~ 238 (351) .+.. ..+|.+...--+-+|..+|+..+| +|-+.. ..+..+...++ T Consensus 119 ~~~~~~~~~~~~~~~~v~~~eg~~~a~~~~~~~y~E~SAktg--~nV~e~Fe~~~ 171 (175) T cd01870 119 NDEHTRRELAKMKQEPVKPEEGRDMANKIGAFGYMECSAKTK--EGVREVFEMAT 171 (175) T ss_pred CCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEEEEEECCCC--CCHHHHHHHHH T ss_conf 431467766541046779899999999739972898741488--88789999999 No 74 >cd04135 Tc10 TC10 subfamily. TC10 is a Rho family protein that has been shown to induce microspike formation and neurite outgrowth in vitro. Its expression changes dramatically after peripheral nerve injury, suggesting an important role in promoting axonal outgrowth and regeneration. TC10 regulates translocation of insulin-stimulated GLUT4 in adipocytes and has also been shown to bind directly to Golgi COPI coat proteins. GTP-bound TC10 in vitro can bind numerous potential effectors. Depending on its subcellular localization and distinct functional domains, TC10 can differentially regulate two types of filamentous actin in adipocytes. TC10 mRNAs are highly expressed in three types of mouse muscle tissues: leg skeletal muscle, cardiac muscle, and uterus; they were also present in brain, with higher levels in adults than in newborns. TC10 has also been shown to play a role in regulating the expression of cystic fibrosis transmembrane conductance regulator (CFTR) through interacti Probab=99.31 E-value=3.6e-11 Score=93.85 Aligned_columns=157 Identities=17% Q ss_pred EEEEECCCCCHHHHHHHHCCC--CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 899865988637777755276--678887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDR--DEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r--~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |++||+.|.|||||+.||+.. .+.+.||+.-.|+---..++... ..++|.-+|.-.+..+.....+..+ .+ T Consensus 3 ivliGd~~VGKTsLi~~~~~~~F~~~~~~Ti~~~~~~~i~i~~~~~---~l~iwDtaGqe~~~~~~~~~~~~a~----~~ 75 (174) T cd04135 3 CVVVGDGAVGKTCLLMSYANDAFPEEYVPTVFDHYAVSVTVGGKQY---LLGLYDTAGQEDYDRLRPLSYPMTD----VF 75 (174) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEECCCCEEEECCEEE---EEEEECCCCCHHHHHHHHHHCCCCC----EE T ss_conf 8997079843899999876183167645514403320035688689---9987168887026778897548998----79 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECC- Q ss_conf 8887369846899999999999999999999998526953789999999984146677600111068877997121000- Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDV- 190 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~- 190 (351) +||.|++.+.++=.--+.|++.++++.+. +|+++||+|.|+ T Consensus 76 ilvydit~~~Sf~~i~~~w~~~~~~~~~~--------------------------------------~piilVGnK~DL~ 117 (174) T cd04135 76 LICFSVVNPASFQNVKEEWVPELKEYAPN--------------------------------------VPYLLVGTQIDLR 117 (174) T ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHCCC--------------------------------------CEEEEEECCCCCC T ss_conf 99965586324899999989999861799--------------------------------------5489973563331 Q ss_pred ------CCCCCHHHHHHHHHHHHHHHHHCCCEEEE-EECHHHHHHHHHHHHHHH Q ss_conf ------15887667899999999999860946888-512034567899988875 Q Ver_Hs_NP_0570 191 ------FQDFESEKRKVICKTLRFVAHYYGASLMF-TSKSEALLLKIRGVINQL 237 (351) Q Consensus 191 ------F~~~D~e~rK~i~r~LR~iAH~yGA~L~F-tSk~e~l~~r~r~~inhl 237 (351) =+-.+..+|.+-..--+-+|..+|+.++| +|-+.. ..+..+..++ T Consensus 118 ~~~~~~~~~~~~~~r~Vs~eeg~~~a~~~~~~~f~EtSAkt~--~~V~e~F~~~ 169 (174) T cd04135 118 DDPKTLARLNDMKEKPVTVEQGQKLAKEIGAHCYVECSALTQ--KGLKTVFDEA 169 (174) T ss_pred CCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEECCCC--CCHHHHHHHH T ss_conf 214677665420267789899999999808924688741467--7778999999 No 75 >cd04121 Rab40 Rab40 subfamily. This subfamily contains Rab40a, Rab40b, and Rab40c, which are all highly homologous. In rat, Rab40c is localized to the perinuclear recycling compartment (PRC), and is distributed in a tissue-specific manor, with high expression in brain, heart, kidney, and testis, low expression in lung and liver, and no expression in spleen and skeletal muscle. Rab40c is highly expressed in differentiated oligodendrocytes but minimally expressed in oligodendrocyte progenitors, suggesting a role in the vesicular transport of myelin components. Unlike most other Ras-superfamily proteins, Rab40c was shown to have a much lower affinity for GTP, and an affinity for GDP that is lower than for GTP. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide d Probab=99.31 E-value=5.3e-11 Score=92.74 Aligned_columns=153 Identities=17% Q ss_pred EEEEECCCCCHHHHHHHHC--CCCCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 8998659886377777552--76678887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCL--DRDEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl--~r~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |++||+.+.|||||+.||. .-.+.+.||++.+|..-.-...+... ..++|.-+|--.+..+...-.+. .-.+ T Consensus 9 IVliGd~~VGKTSLi~rf~~~~f~~~y~~TiG~d~~~k~i~vdg~~v--~L~IWDTAGqE~f~sl~~~y~r~----A~gv 82 (235) T cd04121 9 FLLVGDSDVGKGEILASLQDGSTESPYGYNMGIDYKTTTILLDGRRV--KLQLWDTSGQGRFCTIFRSYSRG----AQGI 82 (235) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEEECCCEE--EEEEEECCCCCHHHCCCHHHHCC----CCCE T ss_conf 99981698447888776425810676343024467899998858289--99987466410011000233214----7717 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) +||.|+++.+++=. ++.|++.++++... +|+++||+|.|+ T Consensus 83 ILVYDIT~r~SF~~-i~~W~~ei~~~~~~--------------------------------------ipiILVGNK~DL- 122 (235) T cd04121 83 ILVYDITNRWSFDG-IDRWIKEIDEHAPG--------------------------------------VPKILVGNRLHL- 122 (235) T ss_pred EEEEECCCHHHHHH-HHHHHHHHHHHCCC--------------------------------------CEEEEEECCCCH- T ss_conf 99987699778999-99999999863289--------------------------------------659997032240- Q ss_pred CCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHH Q ss_conf 58876678999999999998609468885120345678999888750 Q Ver_Hs_NP_0570 192 QDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLA 238 (351) Q Consensus 192 ~~~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r~r~~inhl~ 238 (351) .++|.+-..--+.+|..+|+.-+-+|-+++ .++..+-++++ T Consensus 123 ----~~~R~Vs~eEg~~~A~~~~~~FfEtSAKtn--~NV~E~F~ela 163 (235) T cd04121 123 ----AFKRQVATEQAQAYAERNGMTFFEVSPLCN--FNITESFTELA 163 (235) T ss_pred ----HHCCCCCHHHHHHHHHHCCCCEEEEECCCC--CCHHHHHHHHH T ss_conf ----023777989999999966995999853689--98889999999 No 76 >d1m7ba_ c.37.1.8 (A:) RhoE (RND3) {Mouse (Mus musculus)} SCOP: d1gwnc_ Probab=99.31 E-value=5.2e-11 Score=92.79 Aligned_columns=158 Identities=18% Q ss_pred EEEEECCCCCHHHHHHHHCCC--CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 899865988637777755276--678887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDR--DEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r--~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |+++|+.|+|||||++||+.. .+...||+.-+|+..-..++..- -.++|..+|...+..+....++. .-.+ T Consensus 5 I~iiG~~~vGKSsli~~~~~~~f~~~~~~ti~~~~~~~~~~~~~~~---~~~i~Dt~g~~~~~~~~~~~~~~----~d~~ 77 (179) T d1m7ba_ 5 IVVVGDSQCGKTALLHVFAKDCFPENYVPTVFENYTASFEIDTQRI---ELSLWDTSGSPYYDNVRPLSYPD----SDAV 77 (179) T ss_dssp EEEEESTTSSHHHHHHHHHHSCCCSSCCCCSEEEEEEEEECSSCEE---EEEEEEECCSGGGTTTGGGGCTT----CSEE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEECCEEE---EEEEEECCCCCCCCCCCHHHHCC----CCEE T ss_conf 9997079987899999986284267624406888888655155689---99987135511003122033317----8769 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) ++|+|++.+.++=...++|+..++..... +|+++||+|.|+- T Consensus 78 ilv~d~~~~~S~~~~~~~~~~~~~~~~~~--------------------------------------~piilVgnK~DL~ 119 (179) T d1m7ba_ 78 LICFDISRPETLDSVLKKWKGEIQEFCPN--------------------------------------TKMLLVGCKSDLR 119 (179) T ss_dssp EEEEETTCHHHHHHHHHTHHHHHHHHCTT--------------------------------------CEEEEEEECGGGG T ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHCCC--------------------------------------CCEEEEECCCCCC T ss_conf 99986376146888853348999973487--------------------------------------5046564155544 Q ss_pred CC-------CCHHHHHHHHHHHHHHHHHCCCEEEE-EECHHHHHHH-HHHHHHHHH Q ss_conf 58-------87667899999999999860946888-5120345678-999888750 Q Ver_Hs_NP_0570 192 QD-------FESEKRKVICKTLRFVAHYYGASLMF-TSKSEALLLK-IRGVINQLA 238 (351) Q Consensus 192 ~~-------~D~e~rK~i~r~LR~iAH~yGA~L~F-tSk~e~l~~r-~r~~inhl~ 238 (351) ++ .+...+.+...-.+-+|-.+|+-.+| +|-... .+ +..+-.-.. T Consensus 120 ~~~~~~~~~~~~~~~~Vs~~e~~~la~~~~~~~y~E~SA~~~--~n~v~~vF~~~~ 173 (179) T d1m7ba_ 120 TDVSTLVELSNHRQTPVSYDQGANMAKQIGAATYIECSALQS--ENSVRDIFHVAT 173 (179) T ss_dssp GCHHHHHHHHTTTCCCCCHHHHHHHHHHHTCSEEEECBTTTB--HHHHHHHHHHHH T ss_pred CCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEEECCC--CCHHHHHHHHHH T ss_conf 311356655420377479899999999718943898740368--741899999999 No 77 >1z2a_A RAS-related protein RAB-23; RAB GTPase, vesicular trafficking, protein transport; HET: GDP; 1.90A {Mus musculus} SCOP: c.37.1.8 Probab=99.30 E-value=2.4e-11 Score=94.94 Aligned_columns=153 Identities=19% Q ss_pred EEEEECCCCCHHHHHHHHCCC--CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 899865988637777755276--678887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDR--DEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r--~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |+++|+.|+|||||++||... .+.+.||++.+|..-.....+... ..++|+.+|......+....++.... + T Consensus 8 i~ivG~~~vGKSsll~~~~~~~~~~~~~~t~~~~~~~~~~~~~~~~~--~~~~~d~~g~~~~~~~~~~~~~~~~~----~ 81 (168) T 1z2a_A 8 MVVVGNGAVGKSSMIQRYCKGIFTKDYKKTIGVDFLERQIQVNDEDV--RLMLWDTAGQEEFDAITKAYYRGAQA----C 81 (168) T ss_dssp EEEECSTTSSHHHHHHHHHHCCCCCCSSCCCSSSEEEEEEEETTEEE--EEEEECCTTGGGTTCCCHHHHTTCCE----E T ss_pred EEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCEECCCCCCEE--EEEEECCCCCCCCCHHHHHHHHCCHH----H T ss_conf 99981899778999999863814654221012210000103588158--98641157753100101344311011----0 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) ++|+|++.|..+ +.+..|+..++.+... +|+++||+|.|.. T Consensus 82 i~v~d~~~~~s~-~~~~~~~~~i~~~~~~--------------------------------------~~iilvgnK~Dl~ 122 (168) T 1z2a_A 82 VLVFSTTDRESF-EAISSWREKVVAEVGD--------------------------------------IPTALVQNKIDLL 122 (168) T ss_dssp EEEEETTCHHHH-HTHHHHHHHHHHHHCS--------------------------------------CCEEEEEECGGGG T ss_pred HHHHHHHHHHHH-HHHHHHHHHHHHCCCC--------------------------------------CEEEEEECCCCHH T ss_conf 111110011233-3322100001210688--------------------------------------2389973135712 Q ss_pred CCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHH Q ss_conf 58876678999999999998609468885120345678999888750 Q Ver_Hs_NP_0570 192 QDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLA 238 (351) Q Consensus 192 ~~~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r~r~~inhl~ 238 (351) .+ +.+...-++.+|-.+|+..+.+|-... ..+..+++.++ T Consensus 123 ~~-----~~v~~~~~~~~a~~~~~~~~e~Sa~~~--~~i~~l~~~l~ 162 (168) T 1z2a_A 123 DD-----SCIKNEEAEGLAKRLKLRFYRTSVKED--LNVSEVFKYLA 162 (168) T ss_dssp GG-----CSSCHHHHHHHHHHHTCEEEECBTTTT--BSSHHHHHHHH T ss_pred HH-----HHHHHHHHHHHHHHCCCCEEEEECCCC--CCHHHHHHHHH T ss_conf 32-----100478999999965991899861589--78889999999 No 78 >1ek0_A GTP-binding protein YPT51; vesicular traffic, GTP hydrolysis, YPT/RAB protein, endocytosis, hydrolase; HET: MHO GNP GDP; 1.48A {Saccharomyces cerevisiae} SCOP: c.37.1.8 Probab=99.30 E-value=6.2e-11 Score=92.31 Aligned_columns=157 Identities=24% Q ss_pred EEEEECCCCCHHHHHHHHC--CCCCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 8998659886377777552--76678887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCL--DRDEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl--~r~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |+|+|..|+|||||++|+. .-.+.+.||++.+|.--.....+... ..++|+.+|......+.....+.-+. + T Consensus 6 i~ivG~~~vGKSsLi~~~~~~~~~~~~~~t~~~~~~~~~~~~~~~~~--~l~i~d~~g~~~~~~~~~~~~~~~~~----~ 79 (170) T 1ek0_A 6 LVLLGEAAVGKSSIVLRFVSNDFAENKEPTIGAAFLTQRVTINEHTV--KFEIWDTAGQERFASLAPXYYRNAQA----A 79 (170) T ss_dssp EEEECSTTSSHHHHHHHHHHSCCCTTCCCCSSEEEEEEEEEETTEEE--EEEEEEECCSGGGGGGHHHHHTTCSE----E T ss_pred EEEECCCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEECCCCCCCC--CEEEECCCCCHHHHHHHHHHCCCCCE----E T ss_conf 99881799778999999864834655343102345542000122343--02430344511232220111256503----7 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) ++|+|++++..+ ..+..|++.......+ ..|+++||+|.|.. T Consensus 80 i~v~d~~~~~s~-~~~~~~~~~~~~~~~~-------------------------------------~~~iivv~nK~D~~ 121 (170) T 1ek0_A 80 LVVYDVTKPQSF-IKARHWVKELHEQASK-------------------------------------DIIIALVGNKIDXL 121 (170) T ss_dssp EEEEETTCHHHH-HHHHHHHHHHHHHSCT-------------------------------------TCEEEEEEECGGGG T ss_pred EEEEECCCCCHH-HHHHHHHHHHHHHCCC-------------------------------------CCCEEEEECCCCCC T ss_conf 899702365045-5667888888641135-------------------------------------64334541153100 Q ss_pred CCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHH Q ss_conf 58876678999999999998609468885120345678999888750 Q Ver_Hs_NP_0570 192 QDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLA 238 (351) Q Consensus 192 ~~~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r~r~~inhl~ 238 (351) ..... +++...-.+.+|-.+++..+.+|-+.. ..+..+.+.++ T Consensus 122 ~~~~~--~~v~~~~~~~~~~~~~~~~~e~Sa~~~--~gi~elf~~i~ 164 (170) T 1ek0_A 122 QEGGE--RKVAREEGEKLAEEKGLLFFETSAKTG--ENVNDVFLGIG 164 (170) T ss_dssp GSSCC--CCSCHHHHHHHHHHHTCEEEECCTTTC--TTHHHHHHHHH T ss_pred CHHHH--HHHHHHHHHHHHHHCCCEEEEEECCCC--CCHHHHHHHHH T ss_conf 00000--110078999999865983999862688--68889999999 No 79 >PF00071 Ras: Ras family; InterPro: IPR013753 Many members of the Ras superfamily of GTPases have been implicated in the regulation of hematopoietic cells, with roles in growth, survival, differentiation, cytokine production, chemotaxis, vesicle-trafficking, and phagocytosis. The Ras superfamily of proteins now includes over 150 small GTPases (distinguished from the large, heterotrimeric GTPases, the G-proteins). It comprises six subfamilies, the Ras, Rho, Ran, Rab, Arf, and Kir/Rem/Rad subfamilies . They exhibit remarkable overall amino acid identities, especially in the regions interacting with the guanine nucleotide exchange factors that catalyze their activation . ; PDB: 2fol_A 1ukv_Y 1yzn_A 2bcg_Y 1g17_B 1g16_C 3rab_A 1zbd_A 2ew1_A 1x3s_A .... Probab=99.30 E-value=8.6e-11 Score=91.43 Aligned_columns=158 Identities=23% Q ss_pred EEEEECCCCCHHHHHHHHC-CCCC-CCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 8998659886377777552-7667-8887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCL-DRDE-PPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl-~r~e-~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |+++|+.|.|||||++||+ +... .+.||+|.|+..-.-.-.+... -.++|-.+|--.+..|.+.-++ ....+ T Consensus 2 iiliG~~~vGKTsl~~r~~~~~f~~~y~~TiG~d~~~~~i~~~~~~v--~l~iwDTaGqe~f~~l~~~~~~----~a~~~ 75 (174) T PF00071_consen 2 IILIGDSGVGKTSLIKRFVEGEFIESYTPTIGVDFYSKTIQIDGKSV--KLQIWDTAGQERFRSLRSSYYR----NADGV 75 (174) T ss_dssp EEEEESTTSSHHHHHHHHHHSSSSSSCETSSSEEEEEEEEEETTEEE--EEEEEEETSSGGGHHHHHHHHT----TESEE T ss_pred EEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCEE--EEEEEEEECCCCCCCCCHHHEE----EEEEE T ss_conf 78880898533342001211344111224444012232002677347--8988731023100122001100----11246 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) +||.|++.+.++=.- ..|+..++.... ..-.+|+++||+|+|+. T Consensus 76 ilvydit~~~Sf~~i-~~w~~~i~~~~~-----------------------------------~~~~~~iiLVGnK~DL~ 119 (174) T PF00071_consen 76 ILVYDITNRESFENI-KKWIEEIKKIAP-----------------------------------KDENIPIILVGNKSDLK 119 (174) T ss_dssp EEEEETTHHHHHHHH-HHHHHHHHHHST-----------------------------------SSTTSEEEEEEETTCGG T ss_pred EEEEEEECCCEEHHH-HHHHHHHCCCCC-----------------------------------CCCHHHEEEEECCCCCC T ss_conf 678753001100001-222232002556-----------------------------------32001100111035443 Q ss_pred CCCCHH-------HHHHHHHHHHHHHHHCC-CEEEEEECHHHHHHHHHHHHHHHH Q ss_conf 588766-------78999999999998609-468885120345678999888750 Q Ver_Hs_NP_0570 192 QDFESE-------KRKVICKTLRFVAHYYG-ASLMFTSKSEALLLKIRGVINQLA 238 (351) Q Consensus 192 ~~~D~e-------~rK~i~r~LR~iAH~yG-A~L~FtSk~e~l~~r~r~~inhl~ 238 (351) + .+ .|.+--.-...+|-.+| ...+-+|-.+. ..+..+...++ T Consensus 120 ~---~~~~~~~~~~r~V~~~e~~~~a~~~~~~~~~EtSAk~~--~ni~~~F~~l~ 169 (174) T PF00071_consen 120 E---EESTELENKQRQVSTEEAQQLAKKLGAIKFFETSAKTG--ENIEELFQTLI 169 (174) T ss_dssp G---CHHHHHCTSGSSSHHHHHHHHHHHTTSSEEEEEBTTTT--TTHHHHHHHHH T ss_pred C---CCHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCC--CCHHHHHHHHH T ss_conf 3---10010002210245577889998733874168644678--78789999999 No 80 >cd04131 Rnd Rnd subfamily. The Rnd subfamily contains Rnd1/Rho6, Rnd2/Rho7, and Rnd3/RhoE/Rho8. These novel Rho family proteins have substantial structural differences compared to other Rho members, including N- and C-terminal extensions relative to other Rhos. Rnd3/RhoE is farnesylated at the C-terminal prenylation site, unlike most other Rho proteins that are geranylgeranylated. In addition, Rnd members are unable to hydrolyze GTP and are resistant to GAP activity. They are believed to exist only in the GTP-bound conformation, and are antagonists of RhoA activity. Most Rho proteins contain a lipid modification site at the C-terminus, with a typical sequence motif CaaX, where a = an aliphatic amino acid and X = any amino acid. Lipid binding is essential for membrane attachment, a key feature of most Rho proteins. Due to the presence of truncated sequences in this CD, the lipid modification site is not available for annotation. Probab=99.30 E-value=3.3e-11 Score=94.04 Aligned_columns=143 Identities=20% Q ss_pred EEEEECCCCCHHHHHHHHCCC--CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 899865988637777755276--678887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDR--DEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r--~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |++||+.+.|||||++||... .+.+.||++-.|+-.-..+++.- -.++|..+|.-.+..|...-.+ ..-.+ T Consensus 4 ivlvGd~~VGKTsli~r~~~~~F~~~~~~Ti~~~~~~~~~v~~~~v---~l~iWDTaGqe~f~~l~~~~y~----~a~~~ 76 (178) T cd04131 4 IVVVGDVQCGKTALLQVFAKDCYPETYVPTVFENYTASFEIDEQRI---ELSLWDTSGSPYYDNVRPLCYP----DSDAV 76 (178) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEECCEEE---EEEEEECCCCCHHHHHHHHHCC----CCCEE T ss_conf 8998269844899999975383376624136645789998868489---9998756888033557687627----99679 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) +||+|++.|.++=.-+..|+..++++... +|+++||+|.|+= T Consensus 77 ilvfdit~~~Sf~~v~~~W~~ei~~~~~~--------------------------------------~~iiLVGnK~DLr 118 (178) T cd04131 77 LICFDISRPETLDSVLKKWRGEIQEFCPN--------------------------------------TKVLLVGCKTDLR 118 (178) T ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHCCC--------------------------------------CEEEEEECCCCCC T ss_conf 99975688557789999999999984598--------------------------------------5399960421221 Q ss_pred CCCC-------HHHHHHHHHHHHHHHHHCCCEEEE-EE Q ss_conf 5887-------667899999999999860946888-51 Q Ver_Hs_NP_0570 192 QDFE-------SEKRKVICKTLRFVAHYYGASLMF-TS 221 (351) Q Consensus 192 ~~~D-------~e~rK~i~r~LR~iAH~yGA~L~F-tS 221 (351) .+.. ..++.+-.--=.-+|..+||.++| +| T Consensus 119 ~~~~~~~~l~~~~~~~Vs~eeg~~~A~~~~a~~y~E~S 156 (178) T cd04131 119 TDLSTLMELSHQRQAPVSYEQGCAIAKQLGAEIYLECS 156 (178) T ss_pred CCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEE T ss_conf 21567888763578778989999999982992577530 No 81 >d1ky3a_ c.37.1.8 (A:) Rab-related protein ypt7p {Baker's yeast (Saccharomyces cerevisiae)} SCOP: d1ky2a_ Probab=99.29 E-value=1.4e-10 Score=90.17 Aligned_columns=160 Identities=24% Q ss_pred EEEEECCCCCHHHHHHHHC--CCCCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 8998659886377777552--76678887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCL--DRDEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl--~r~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |+++|..|+||||||+||+ .-.+.+.||++.+|...+.. ..+...-..++|..+|......+....+..-. .+ T Consensus 5 i~iiG~~~vGKStli~~l~~~~~~~~~~~t~~~~~~~~~~~-~~~~~~~~~~i~d~~~~~~~~~~~~~~~~~~d----~~ 79 (175) T d1ky3a_ 5 VIILGDSGVGKTSLMHRYVNDKYSQQYKATIGADFLTKEVT-VDGDKVATMQVWDTAGQERFQSLGVAFYRGAD----CC 79 (175) T ss_dssp EEEECCTTSSHHHHHHHHHHSCCCTTC---CCCSCEEEEEC-CSSSCCEEEEEECCC----------CCSTTCC----EE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEE-ECCCCEEEEEEECCCHHHHHHHHHHHHHCCCC----EE T ss_conf 99980799889999999864801566145167535677776-33661489997115101233110021211110----22 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) ++|+|++.+.. +..++.|++.++.+.+ ...+-.+|++|||+|+|+ T Consensus 80 ilv~D~~~~~s-~~~~~~~~~~i~~~~~---------------------------------~~~~~~~Piiiv~nK~Dl- 124 (175) T d1ky3a_ 80 VLVYDVTNASS-FENIKSWRDEFLVHAN---------------------------------VNSPETFPFVILGNKIDA- 124 (175) T ss_dssp EEEEETTCHHH-HHTHHHHHHHHHHHHC---------------------------------CSCTTTCCEEEEEECTTS- T ss_pred EEEEECCCCCC-HHHHHHHHHHHHHHHH---------------------------------HCCCCCEEEEEEEECCCC- T ss_conf 44320036561-4577776899999863---------------------------------128897279998512464- Q ss_pred CCCCHHHHHHHHHHHHHHHHHCCCEEEE-EECHHHHHHHHHHHHHHHH Q ss_conf 5887667899999999999860946888-5120345678999888750 Q Ver_Hs_NP_0570 192 QDFESEKRKVICKTLRFVAHYYGASLMF-TSKSEALLLKIRGVINQLA 238 (351) Q Consensus 192 ~~~D~e~rK~i~r~LR~iAH~yGA~L~F-tSk~e~l~~r~r~~inhl~ 238 (351) ..+.+.+--.-++.+|-.+|..-+| +|-... ..+..+...++ T Consensus 125 ---~~~~~~~~~~~~~~~~~~~~~~~~~e~Sa~~g--~gi~e~f~~i~ 167 (175) T d1ky3a_ 125 ---EESKKIVSEKSAQELAKSLGDIPLFLTSAKNA--INVDTAFEEIA 167 (175) T ss_dssp ---CGGGCCSCHHHHHHHHHHTTSCCEEEEBTTTT--BSHHHHHHHHH T ss_pred ---CCCCCCCCHHHHHHHHHHHCCCCEEEEECCCC--CCHHHHHHHHH T ss_conf ---00026556889999999807971899861688--68889999999 No 82 >cd04143 Rhes_like Rhes_like subfamily. This subfamily includes Rhes (Ras homolog enriched in striatum) and Dexras1/AGS1 (activator of G-protein signaling 1). These proteins are homologous, but exhibit significant differences in tissue distribution and subcellular localization. Rhes is found primarily in the striatum of the brain, but is also expressed in other areas of the brain, such as the cerebral cortex, hippocampus, inferior colliculus, and cerebellum. Rhes expression is controlled by thyroid hormones. In rat PC12 cells, Rhes is farnesylated and localizes to the plasma membrane. Rhes binds and activates PI3K, and plays a role in coupling serpentine membrane receptors with heterotrimeric G-protein signaling. Rhes has recently been shown to be reduced under conditions of dopamine supersensitivity and may play a role in determining dopamine receptor sensitivity. Dexras1/AGS1 is a dexamethasone-induced Ras protein that is expressed primarily in the brain, with low expression l Probab=99.29 E-value=4.5e-10 Score=86.83 Aligned_columns=182 Identities=19% Q ss_pred EEEEECCCCCHHHHHHHHCCC--CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 899865988637777755276--678887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDR--DEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r--~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |+++|+.+.|||||++||+.. .+.+.||++ .|.++.-.-....--.++|.-+|--.+..|...-+...+ .+ T Consensus 3 IVllGd~~VGKTSLi~Rf~~~~F~e~y~pTI~---df~~K~i~idg~~v~L~IwDTAGqE~f~sl~~~~~~~ad----~~ 75 (247) T cd04143 3 MVVLGASKVGKTAIVSRFLGGRFEEQYTPTIE---DFHRKLYSIRGEVYQLDILDTSGNHPFPAMRRLSILTGD----VF 75 (247) T ss_pred EEEEECCCCCHHHHHHHHHCCEECCCCCCCCC---CEEEEEEEECCEEEEEEEECCCCCCCCCCCCCCCCCCCC----EE T ss_conf 89982698318889887653832676234210---005789988792899997225446545543402103887----89 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) +||.|++.+.+ ++.++.|++.++..-.....+..... .+|++|||+|.|. T Consensus 76 ILVyDIT~r~S-Fe~v~~w~~eI~e~k~~~~~~~~~~~----------------------------~vpiILVGNK~DL- 125 (247) T cd04143 76 ILVFSLDNRES-FEEVCRLREQILETKSCLKNKTKENV----------------------------KIPMVICGNKADR- 125 (247) T ss_pred EEEEECCCHHH-HHHHHHHHHHHHHHHHHHCCCCCCCC----------------------------CCEEEEEECCCCC- T ss_conf 99975699789-99999999999986311002345788----------------------------7279997055673- Q ss_pred CCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHH--HHHHHHHHHC----CCCCCCEEEEECCCCE Q ss_conf 58876678999999999998609468885120345678--9998887505----7777730575067757 Q Ver_Hs_NP_0570 192 QDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLK--IRGVINQLAF----GIDKSKSICVDQNKPL 255 (351) Q Consensus 192 ~~~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r--~r~~inhl~F----G~~~~k~~~~D~~kPl 255 (351) +.+..-..-.+.+++|-.+|+..+-+|-+.+..+. |+.|..+... .-..++-+++.+-.|+ T Consensus 126 ---~~~R~Vs~eEa~q~~A~~~~~~ffEtSAKtg~NVdE~F~~L~~~~~l~~~~~p~~~~~~~~~~~~~~ 192 (247) T cd04143 126 ---DFPREVQRDEVEQLVGGDENCAYFEVSAKKNSNLDEMFRALFSLAKLPNEMSPSLHRKISVQYGDAL 192 (247) T ss_pred ---CCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCHHEEEEEEECCCC T ss_conf ---2257338899999999827982899852589888999999998648732268204103232215534 No 83 >e1z0fa_ c.37.1.8 (A:) Rab14 {Human (Homo sapiens) [TaxID:9606]} SCOP: u2aeda1 Probab=99.28 E-value=2e-10 Score=89.16 Aligned_columns=154 Identities=16% Q ss_pred EEEEECCCCCHHHHHHHHCCCC--CCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 8998659886377777552766--78887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDRD--EPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r~--e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |+++|..|+||||||+|++... +...||.+.++..-.....+... ..++|+.+|......+...-+..-. .+ T Consensus 8 i~ivG~~~vGKTsLi~~~~~~~~~~~~~~t~~~~~~~~~~~~~~~~~--~i~i~d~~g~~~~~~~~~~~~~~~d----~~ 81 (167) T e1z0fa_ 8 YIIIGDMGVGKSCLLHQFTEKKFMADCPHTIGVEFGTRIIEVSGQKI--KLQIWDTAGQERFRAVTRSYYRGAA----GA 81 (167) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEEECCCEE--EEEEECCCCCCHHHHHHHHHCCCCC----EE T ss_conf 99981799779999999864823566541244332016898779325--7877216773012121032236886----79 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) ++|+|++.+.++=.-..+| ..+. ......+|++|||+|.|. T Consensus 82 i~v~d~~~~~s~~~~~~~~--------~~~~------------------------------~~~~~~~~iiiv~nK~Dl- 122 (167) T e1z0fa_ 82 LMVYDITRRSTYNHLSSWL--------TDAR------------------------------NLTNPNTVIILIGNKADL- 122 (167) T ss_pred EEEEECCCCHHHHHHHHHH--------HHHH------------------------------HHHCCCCEEEEEEECCHH- T ss_conf 9998527740289999888--------8898------------------------------861787258875211021- Q ss_pred CCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHH Q ss_conf 58876678999999999998609468885120345678999888750 Q Ver_Hs_NP_0570 192 QDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLA 238 (351) Q Consensus 192 ~~~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r~r~~inhl~ 238 (351) ..++.+..+-++.+|-.+|+.++++|-... ..+..+...++ T Consensus 123 ----~~~~~i~~~e~~~~~~~~~~~~~e~Sa~~g--~gi~elf~~i~ 163 (167) T e1z0fa_ 123 ----EAQRDVTYEEAKQFAEENGLLFLEASAKTG--ENVEDAFLEAA 163 (167) T ss_pred ----HHCCCCCHHHHHHHHHHCCCEEEEEECCCC--CCHHHHHHHHH T ss_conf ----000243178999999964982999962689--88889999999 No 84 >cd00877 Ran Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases. Ran GTPase is involved in diverse biological functions, such as nuclear transport, spindle formation during mitosis, DNA replication, and cell division. Among the Ras superfamily, Ran is a unique small G protein. It does not have a lipid modification motif at the C-terminus to bind to the membrane, which is often observed within the Ras superfamily. Ran may therefore interact with a wide range of proteins in various intracellular locations. Like other GTPases, Ran exists in GTP- and GDP-bound conformations that interact differently with effectors. Conversion between these forms and the assembly or disassembly of effector complexes requires the interaction of regulator proteins. The intrinsic GTPase activity of Ran is very low, but it is greatly stimulated by a GTPase-activating protein (RanGAP1) located in the cytoplasm. By contrast, RCC1, a guanine nucleotide exchange factor that generates RanGTP, is Probab=99.28 E-value=1.4e-10 Score=90.15 Aligned_columns=151 Identities=21% Q ss_pred EEEEECCCCCHHHHHHHHCCC--CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 899865988637777755276--678887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDR--DEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r--~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |.++|+.+.|||||+.||++. .+.+.||.+.++..-.-...+... -.++|..+|--.+..|.+.-++ ..-.+ T Consensus 3 IvliGd~~VGKTsli~r~~~~~F~~~y~~Tig~~~~~~~~~~~~~~i--~l~iwDtaG~e~f~~l~~~y~~----~a~~~ 76 (166) T cd00877 3 LVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLDFHTNRGKI--RFNVWDTAGQEKFGGLRDGYYI----GGQCA 76 (166) T ss_pred EEEEECCCCCHHHHHHHHHCCEECCCCCCEEEEEEEEEEEEECCCEE--EEEEEECCCCCCCCCCCCCCCC----CCCEE T ss_conf 89982698448999888763811666453464488899999879479--9998845785213545512000----26758 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) +||.|++.++++=. +..|++.+++..+. +|++|||+|.|+ T Consensus 77 ilvfDit~~~Sf~~-i~~w~~~i~~~~~~--------------------------------------ipivlVGNK~Dl- 116 (166) T cd00877 77 IIMFDVTSRVTYKN-VPNWHRDLVRVCGN--------------------------------------IPIVLCGNKVDI- 116 (166) T ss_pred EEEEECCCHHHHHH-HHHHHHHHHHHCCC--------------------------------------CCEEEEECCCCC- T ss_conf 99986699789898-98899999864599--------------------------------------658999326773- Q ss_pred CCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHH Q ss_conf 58876678999999999998609468885120345678999888750 Q Ver_Hs_NP_0570 192 QDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLA 238 (351) Q Consensus 192 ~~~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r~r~~inhl~ 238 (351) +.++...+...+.... |+..+.+|-++. .++..+..+++ T Consensus 117 -----~~~~~~~~~~~~~~~~-~~~~~EtSAk~g--~NV~e~F~~la 155 (166) T cd00877 117 -----KDRKVKAKQITFHRKK-NLQYYEISAKSN--YNFEKPFLWLA 155 (166) T ss_pred -----CCCCCCHHHHHHHHHC-CCCEEEEECCCC--CCHHHHHHHHH T ss_conf -----2011248999999957-994999970489--89889999999 No 85 >2rex_B RHO-related GTP-binding protein RHO6; complex, structural genomics consortium, SGC, GTPase, GNP, plexin, effector domain, alternative splicing; HET: GNP; 2.30A {Homo sapiens} Probab=99.28 E-value=3.1e-11 Score=94.21 Aligned_columns=166 Identities=16% Q ss_pred EEEEECCCCCHHHHHHHHCCC--CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 899865988637777755276--678887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDR--DEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r--~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |+|||+.++||||||+||++. .+.+.||++-+|+......+..- -.++|..+|...+..+....++ ..-.+ T Consensus 13 i~vvG~~~vGKTsli~~~~~~~~~~~~~~t~~~~~~~~~~~~~~~~---~l~iwD~~g~~~~~~~~~~~~~----~~~~~ 85 (197) T 2rex_B 13 LVLVGDVQCGKTAMLQVLAKDCYPETYVPTVFENYTACLETEEQRV---ELSLWDTSGSPYYDNVRPLCYS----DSDAV 85 (197) T ss_dssp EEEECSTTSSHHHHHHHHHHSCCCCSCCCCSEEEEEEEE---CCCE---EEEEEEECCSGGGTTTGGGGGT----TCSEE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEEECEEE---EEEEECCCCCCCCCCCCCCCCC----CEEEE T ss_conf 9998169987899999986175576534327775677523202145---7764113121122212300010----11235 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) ++|+|++++.++=..+++|+..++..... +|+++||+|+|+= T Consensus 86 i~v~d~~~~~S~~~~~~~~~~~~~~~~~~--------------------------------------~~iilVgnK~DL~ 127 (197) T 2rex_B 86 LLCFDISRPETVDSALKKWRTEILDYCPS--------------------------------------TRVLLIGCKTDLR 127 (197) T ss_dssp EEEEETTCTTTC--CHHHHHHHHHHHCTT--------------------------------------SEEEEEEECGGGG T ss_pred EEEECCCHHHHHHHHHHHHHHHHHHHCCC--------------------------------------CEEEEEECCCCCC T ss_conf 76304560678999998877767761799--------------------------------------4799950456863 Q ss_pred CC-------CCHHHHHHHHHHHHHHHHHCCCEEEE--EECHHHHHHH-HHHHHHHHHCCCCCC Q ss_conf 58-------87667899999999999860946888--5120345678-999888750577777 Q Ver_Hs_NP_0570 192 QD-------FESEKRKVICKTLRFVAHYYGASLMF--TSKSEALLLK-IRGVINQLAFGIDKS 244 (351) Q Consensus 192 ~~-------~D~e~rK~i~r~LR~iAH~yGA~L~F--tSk~e~l~~r-~r~~inhl~FG~~~~ 244 (351) .+ .+...+.+-..-.+.+|-.+|+..+| +++....... +-..+..++.+.+.+ T Consensus 128 ~~~~~~~~~~~~~~~~is~~e~~~~a~~~~~~~y~E~Sakt~~~~v~~~f~~~~~~~~~~~~~ 190 (197) T 2rex_B 128 TDLSTLMELSHQKQAPISYEQGCAIAKQLGAEIYLEGSAFTSEKSIHSIFRTASMLCLNKPSP 190 (197) T ss_dssp GCHHHHHHHHHTTCCCCCHHHHHHHHHHTTCSCEEECBTTTBHHHHHHHHHHHHHHHC----- T ss_pred CCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCC T ss_conf 211355665554204678899999999659958998752346612799999999999628788 No 86 >cd04129 Rho2 Rho2 subfamily. Rho2 is a fungal GTPase that plays a role in cell morphogenesis, control of cell wall integrity, control of growth polarity, and maintenance of growth direction. Rho2 activates the protein kinase C homolog Pck2, and Pck2 controls Mok1, the major (1-3) alpha-D-glucan synthase. Together with Rho1 (RhoA), Rho2 regulates the construction of the cell wall. Unlike Rho1, Rho2 is not an essential protein, but its overexpression is lethal. Most Rho proteins contain a lipid modification site at the C-terminus, with a typical sequence motif CaaX, where a = an aliphatic amino acid and X = any amino acid. Lipid binding is essential for proper intracellular localization via membrane attachment. As with other Rho family GTPases, the GDP/GTP cycling is regulated by GEFs (guanine nucleotide exchange factors), GAPs (GTPase-activating proteins) and GDIs (guanine nucleotide dissociation inhibitors). Probab=99.28 E-value=9.5e-11 Score=91.14 Aligned_columns=160 Identities=19% Q ss_pred EEEEECCCCCHHHHHHHHCCC--CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 899865988637777755276--678887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDR--DEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r--~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |++||+.+.|||||+.||... .+.+.||.+-+|.---..++..- ...+|..+|--.+..|.+.-....+ .+ T Consensus 4 ivliGd~~VGKTsL~~r~~~~~F~~~~~pTi~~~~~~~i~v~~~~v---~l~iwDTaGqe~~~~l~~~~~~~a~----~~ 76 (187) T cd04129 4 LVIVGDGACGKTSLLSVFTLGEFPEEYHPTVFENYVTDCRVDGKPV---QLALWDTAGQEEYERLRPLSYSKAH----VI 76 (187) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEECCEEE---EEEEEECCCCCHHHHHHHHHHCCCC----EE T ss_conf 8998259843899999986173277636603665677446778689---9988655765215789998706997----89 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECC- Q ss_conf 8887369846899999999999999999999998526953789999999984146677600111068877997121000- Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDV- 190 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~- 190 (351) +||.|++.+.++-.--++|+..++++..+ +|+++||+|.|+ T Consensus 77 ilvydi~~~~Sf~~i~~~w~~~~~~~~~~--------------------------------------~piiLvGnK~DL~ 118 (187) T cd04129 77 LIGFAVDTPDSLENVRTKWIEEVRRYCPN--------------------------------------VPVILVGLKKDLR 118 (187) T ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHCCC--------------------------------------CEEEEEECCCCCH T ss_conf 99963388567888889889999983689--------------------------------------4499983588711 Q ss_pred ----CCCCCHHHHHHHHHHHHHHHHHCCCEEEE-EECHHHHHHH--HHHHHHHHH Q ss_conf ----15887667899999999999860946888-5120345678--999888750 Q Ver_Hs_NP_0570 191 ----FQDFESEKRKVICKTLRFVAHYYGASLMF-TSKSEALLLK--IRGVINQLA 238 (351) Q Consensus 191 ----F~~~D~e~rK~i~r~LR~iAH~yGA~L~F-tSk~e~l~~r--~r~~inhl~ 238 (351) ......++|.+--.--+.+|...|+--+| +|-+...... |..+....+ T Consensus 119 ~~~~~~~~~~~~r~v~~~e~~~~a~~~~~~~y~EtSAktg~nV~e~Fe~~~r~aL 173 (187) T cd04129 119 QDAVAKEEYRTQRFVPIQQGKRVAKEIGAKKYMECSALTGEGVDDVFEAATRAAL 173 (187) T ss_pred HHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHH T ss_conf 2344321011105689899999999728954788633578787899999999984 No 87 >e1x3sa1 c.37.1.8 (A:2-178) Rab18 {Human (Homo sapiens) [TaxID:9606]} Probab=99.28 E-value=6.7e-11 Score=92.11 Aligned_columns=154 Identities=19% Q ss_pred EEEEECCCCCHHHHHHHHCCCC--CCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 8998659886377777552766--78887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDRD--EPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r~--e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |+++|..|+||||||+|+.... ..+.||++.+|........+... ..++|+.+|......+....++. .-.+ T Consensus 10 i~ivG~~~vGKTtLi~~~~~~~~~~~~~~t~~~~~~~~~~~~~~~~~--~~~l~d~~~~~~~~~~~~~~~~~----~d~~ 83 (177) T e1x3sa1 10 ILIIGESGVGKSSLLLRFTDDTFDPELAATIGVDFKVKTISVDGNKA--KLAIWDTAGQERFRTLTPSYYRG----AQGV 83 (177) T ss_pred EEEECCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEEECCEEE--EEEEECCCCCHHHHHHHHHHCCC----CCEE T ss_conf 89980799879999999864811675146410135678998879489--99971165310222330433157----6068 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) ++|+|++.+.++-. ++.|++.++++... ..+|+++||+|.|. T Consensus 84 i~~~d~~~~~s~~~-~~~~~~~i~~~~~~------------------------------------~~~~iiiv~nK~Dl- 125 (177) T e1x3sa1 84 ILVYDVTRRDTFVK-LDNWLNELETYCTR------------------------------------NDIVNMLVGNKIDK- 125 (177) T ss_pred EEECCCCCCHHHHH-HHHHHHHHHHHCCC------------------------------------CCCCEEEECCCCHH- T ss_conf 98504676101000-13589999974576------------------------------------66322453011001- Q ss_pred CCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHH Q ss_conf 58876678999999999998609468885120345678999888750 Q Ver_Hs_NP_0570 192 QDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLA 238 (351) Q Consensus 192 ~~~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r~r~~inhl~ 238 (351) .++.+...-.+.+|-.+|+..+.+|-... ..+..+.++++ T Consensus 126 -----~~~~v~~~e~~~~~~~~~~~~~e~Sa~~g--~gi~e~f~~i~ 165 (177) T e1x3sa1 126 -----ENREVDRNEGLKFARKHSMLFIEASAKTC--DGVQCAFEELV 165 (177) T ss_pred -----HCCCCCHHHHHHHHHHCCCEEEEEECCCC--CCHHHHHHHHH T ss_conf -----10467888999999965982999861688--78789999999 No 88 >cd04111 Rab39 Rab39 subfamily. Found in eukaryotes, Rab39 is mainly found in epithelial cell lines, but is distributed widely in various human tissues and cell lines. It is believed to be a novel Rab protein involved in regulating Golgi-associated vesicular transport during cellular endocytosis. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site at the C-terminus, with sequence motifs CC, CXC, or CCX. Lipid binding is essential for membrane attachment, a key feature of most Rab proteins. Probab=99.28 E-value=2.3e-10 Score=88.67 Aligned_columns=156 Identities=19% Q ss_pred EEEEECCCCCHHHHHHHHCCC--CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 899865988637777755276--678887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDR--DEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r--~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |+++|+.+.|||||++||++. .+.+.||++.|| |.+...-....+--.++|-.+|--.+..+...-.+ ....+ T Consensus 5 IviiGd~~VGKTsli~rf~~~~F~~~~~~Tig~df-~~k~v~i~dgk~v~L~IwDTaGqE~f~si~~~yyr----~a~g~ 79 (211) T cd04111 5 LIVIGDSTVGKSSLLKRFTEGRFAEVSDPTVGVDF-FSRLIEIEPGVRIKLQLWDTAGQERFRSITRSYYR----NSVGV 79 (211) T ss_pred EEEEECCCCCHHHHHHHHHCCEECCCCCCCEEEEE-EEEEEEECCCCEEEEEEEECCCCHHHHHHHHHHHC----CCCEE T ss_conf 99982698548999988770821676565024688-89999961784799998636997156888888601----89889 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) +||.|++.+. =++.+..|++.++.+.+ |.-+|+++||+|.|+ T Consensus 80 ilVyDit~~~-SFe~i~~w~~ei~~~~~------------------------------------~~~~~~iLVGNK~DL- 121 (211) T cd04111 80 LLVFDITNRE-SFEHVHDWLEEARSHIQ------------------------------------PHRPVFILVGHKCDL- 121 (211) T ss_pred EEEEECCCHH-HHHHHHHHHHHHHHHCC------------------------------------CCCCEEEEECCCCCH- T ss_conf 9998669977-89999999999998518------------------------------------998589997165341- Q ss_pred CCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHH Q ss_conf 58876678999999999998609468885120345678999888750 Q Ver_Hs_NP_0570 192 QDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLA 238 (351) Q Consensus 192 ~~~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r~r~~inhl~ 238 (351) .+.|.+--.--+.+|-.+|+..+-||-+.. .++..+-..++ T Consensus 122 ----~~~R~Vs~eea~~~A~~~~~~f~EtSAktg--~nV~e~F~~la 162 (211) T cd04111 122 ----ESQRQVTREEAEKLAKDLGMKYIETSARTG--DNVEEAFELLT 162 (211) T ss_pred ----HHHHCCCHHHHHHHHHHCCCCEEEEECCCC--CCHHHHHHHHH T ss_conf ----333012489999999966996999963589--88899999999 No 89 >cd04102 RabL3 RabL3 (Rab-like3) subfamily. RabL3s are novel proteins that have high sequence similarity with Rab family members, but display features that are distinct from Rabs, and have been termed Rab-like. As in other Rab-like proteins, RabL3 lacks a prenylation site at the C-terminus. The specific function of RabL3 remains unknown. Probab=99.28 E-value=3.2e-11 Score=94.18 Aligned_columns=158 Identities=20% Q ss_pred EEEEECCCCCHHHHHHHHC--CCCCCCCCCCCCCHHHHHHHCCCCCCCEE---EEEEEECCCCCHHHCEEEEECCCCCCE Q ss_conf 8998659886377777552--76678887531000221110157871117---888971578542021100004235120 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCL--DRDEPPKPTLALEYTYGRRAKGHNTPKDI---AHFWELGGGTSLLDLISIPITGDTLRT 108 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl--~r~e~~KPTlALeYtygRra~~~~~~Kdv---aH~WELGgg~~ls~Li~ipit~~~l~~ 108 (351) |++||+.|.|||||++||. +=.+.|.||.+.++.+-.-.-....+.+- .++|..+|--.+..|.+.-.+ .. T Consensus 3 IvliGDsgVGKTSLi~r~~~~~f~~~~~~TIG~~v~~k~~~~~~~~~~~k~~~lqlWDTAGQEryrsl~~~yYr----~a 78 (202) T cd04102 3 VLVVGDSGVGKSSLVHLICKNQVLGRPSWTVGCSVDVKHHTYKEGTPEEKTFFVELWDVGGSESVKSTRAVFYN----QV 78 (202) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEEECCCCCCCEEEEEEEEECCCCHHHHHHHHHHHC----CC T ss_conf 89982598558999888653711688575166899999998406776640799999853897135667888852----89 Q ss_pred EEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEE Q ss_conf 67788873698468999999999999999999999985269537899999999841466776001110688779971210 Q Ver_Hs_NP_0570 109 FSLVLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKY 188 (351) Q Consensus 109 ~~viivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KY 188 (351) -.++||.|++...++ +.++.|+..+...-. .-+....+-..-|.....-.+||+++||+|. T Consensus 79 ~gvILVyDITnr~SF-enL~~Wl~Eil~k~~------------------~~~~~~~~~~~~~~~~~~~~~ip~lvvGnK~ 139 (202) T cd04102 79 NGIILVHDLTNRKSS-QNLQRWSLEALNKDT------------------FPTGLLVTNGDYDSEQFGGNQIPLLVIGTKL 139 (202) T ss_pred CEEEEEEECCCHHHH-HHHHHHHHHHHCCCC------------------CCCCCCCCCCCCCHHHCCCCCCEEEEECCCC T ss_conf 879999757997899-999999999741465------------------4445666555443012278972089972640 Q ss_pred CCCCCCCHHHHHHHHHHHHHHHHHCCC Q ss_conf 001588766789999999999986094 Q Ver_Hs_NP_0570 189 DVFQDFESEKRKVICKTLRFVAHYYGA 215 (351) Q Consensus 189 D~F~~~D~e~rK~i~r~LR~iAH~yGA 215 (351) |.-.+-.+....+..++ -+|||.-|| T Consensus 140 D~~~~~~~~~~~~~~~~-~~i~~~~~~ 165 (202) T cd04102 140 DQIPEKESSGNLVLTAR-GFVAEQGNA 165 (202) T ss_pred CHHCCCCCCCCCHHHHC-CCHHHHCCC T ss_conf 01103675654000000-013544385 No 90 >cd04127 Rab27A Rab27a subfamily. The Rab27a subfamily consists of Rab27a and its highly homologous isoform, Rab27b. Unlike most Rab proteins whose functions remain poorly defined, Rab27a has many known functions. Rab27a has multiple effector proteins, and depending on which effector it binds, Rab27a has different functions as well as tissue distribution and/or cellular localization. Putative functions have been assigned to Rab27a when associated with the effector proteins Slp1, Slp2, Slp3, Slp4, Slp5, DmSlp, rabphilin, Dm/Ce-rabphilin, Slac2-a, Slac2-b, Slac2-c, Noc2, JFC1, and Munc13-4. Rab27a has been associated with several human diseases, including hemophagocytic syndrome (Griscelli syndrome or GS), Hermansky-Pudlak syndrome, and choroidermia. In the case of GS, a rare, autosomal recessive disease, a Rab27a mutation is directly responsible for the disorder. When Rab27a is localized to the secretory granules of pancreatic beta cells, it is believed to mediate glucose-stimulated Probab=99.28 E-value=1.7e-10 Score=89.51 Aligned_columns=157 Identities=22% Q ss_pred EEEEECCCCCHHHHHHHHCCC--CCCCCCCCCCCHHHHHHHCCCCCCCEE--------EEEEEECCCCCHHHCEEEEECC Q ss_conf 899865988637777755276--678887531000221110157871117--------8889715785420211000042 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDR--DEPPKPTLALEYTYGRRAKGHNTPKDI--------AHFWELGGGTSLLDLISIPITG 103 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r--~e~~KPTlALeYtygRra~~~~~~Kdv--------aH~WELGgg~~ls~Li~ipit~ 103 (351) |+++|+.+.||||||.||+.. .+.+.||.++++.--+-...+..+... ..+|..+|...+..|.....+. T Consensus 7 ivviGd~~vGKTsli~r~~~~~f~~~~~~Tig~~~~~k~i~~~~~~~~~~~~~~~~v~l~iwDtaGqe~~~~l~~~~~~~ 86 (180) T cd04127 7 FLALGDSGVGKTSFLYQYTDNKFNPKFITTVGIDFREKRVVYNSSGPGGTLGRGQRIHLQLWDTAGQERFRSLTTAFFRD 86 (180) T ss_pred EEEEECCCCCHHHHHHHHHCCEECCCCCCEEEEEEEEEEEEEECCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHCCC T ss_conf 99980698438999888763832776354011135577999712554332457727999997247762145676886049 Q ss_pred CCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEE Q ss_conf 35120677888736984689999999999999999999999852695378999999998414667760011106887799 Q Ver_Hs_NP_0570 104 DTLRTFSLVLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVI 183 (351) Q Consensus 104 ~~l~~~~viivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvI 183 (351) .. .++||.|++.++++=. +..|++.++.+.. ..++ |+++ T Consensus 87 a~----~~ilvydit~~~Sf~~-~~~w~~~i~~~~~-------~~~~-----------------------------~ivl 125 (180) T cd04127 87 AM----GFLLIFDLTNEQSFLN-VRNWMSQLQTHAY-------CENP-----------------------------DIVL 125 (180) T ss_pred CC----EEEEEEECCCHHHHHH-HHHHHHHHHHHCC-------CCCC-----------------------------EEEE T ss_conf 98----8999974689668899-9999999986136-------7875-----------------------------0788 Q ss_pred ECCEECCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHH Q ss_conf 7121000158876678999999999998609468885120345678999888750 Q Ver_Hs_NP_0570 184 IGSKYDVFQDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLA 238 (351) Q Consensus 184 Vg~KYD~F~~~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r~r~~inhl~ 238 (351) ||+|+| -.++|.+--.-.+-+|..+|+..+++|-+.. ..+..+...|+ T Consensus 126 VgNK~D-----l~~~r~Vs~~e~~~~a~~~~~~~~e~SAk~~--~nV~e~F~~l~ 173 (180) T cd04127 126 CGNKAD-----LEDQRQVSEEQAKALADKYGIPYFETSAATG--TNVEKAVERLL 173 (180) T ss_pred EECCCC-----CCCCCCCCHHHHHHHHHHCCCCEEEEECCCC--CCHHHHHHHHH T ss_conf 720235-----5211224878999999965995999971479--88789999999 No 91 >2f9l_A RAB11B, member RAS oncogene family; RAB11B GTPase, vesicle transport; HET: GDP; 1.55A {Homo sapiens} SCOP: c.37.1.8 Probab=99.27 E-value=6.2e-11 Score=92.31 Aligned_columns=154 Identities=22% Q ss_pred EEEEECCCCCHHHHHHHHCCC--CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 899865988637777755276--678887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDR--DEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r--~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |++||..++|||||++|++.. .+...||+..++.+.......... ...+|..+|......+....++. .-.+ T Consensus 8 i~ivG~~~vGKTsli~~~~~~~~~~~~~~t~~~~~~~~~~~~~~~~~--~~~i~d~~~~~~~~~~~~~~~~~----~~~~ 81 (199) T 2f9l_A 8 VVLIGDSGVGKSNLLSRFTRNEFNLESKSTIGVEFATRSIQVDGKTI--KAQIWDTAGQERYRRITSAYYRG----AVGA 81 (199) T ss_dssp EEEESSTTSSHHHHHHHHHHSCCCC---CCCSCEEEEEEEEETTEEE--EEEEEECSSGGGTTCCCHHHHTT----CSEE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEEEEEEE--EEEEECCCCCCHHHHHHHHHHCC----CCEE T ss_conf 89982699768999999862833676456145445655543100356--55652453210123566765047----8379 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) ++|+|++.+.+ ++.+..|+..++... ...+|+++||+|+|. T Consensus 82 i~v~d~~~~~s-~~~~~~~~~~~~~~~-------------------------------------~~~~piilVgnK~Dl- 122 (199) T 2f9l_A 82 LLVYDIAKHLT-YENVERWLKELRDHA-------------------------------------DSNIVIMLVGNKSDL- 122 (199) T ss_dssp EEEEETTCHHH-HHTHHHHHHHHHHHS-------------------------------------CTTCEEEEEEECTTC- T ss_pred EEEECCCCHHH-HHHHHHHHHHHHHHC-------------------------------------CCCCEEEEEEECCCC- T ss_conf 99702678668-899998899999834-------------------------------------899779999610572- Q ss_pred CCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHH Q ss_conf 58876678999999999998609468885120345678999888750 Q Ver_Hs_NP_0570 192 QDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLA 238 (351) Q Consensus 192 ~~~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r~r~~inhl~ 238 (351) .+.+.....-.+.+|..+++.++++|-... ..+..+.+.++ T Consensus 123 ----~~~~~~~~~e~~~~a~~~~~~~~e~Saktg--~~v~elf~~l~ 163 (199) T 2f9l_A 123 ----RHLRAVPTDEARAFAEKNNLSFIETSALDS--TNVEEAFKNIL 163 (199) T ss_dssp ----GGGCCSCHHHHHHHHHHTTCEEEECCTTTC--TTHHHHHHHHH T ss_pred ----CCCCCCCHHHHHHHHHHCCCCEEEEEECCC--CCHHHHHHHHH T ss_conf ----200146077888999973897378872378--78889999999 No 92 >d1g16a_ c.37.1.8 (A:) Rab-related protein Sec4 {Baker's yeast (Saccharomyces cerevisiae)} Probab=99.27 E-value=2.8e-10 Score=88.13 Aligned_columns=155 Identities=16% Q ss_pred EEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEEEE Q ss_conf 89986598863777775527667888753100022111015787111788897157854202110000423512067788 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDRDEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSLVL 113 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~vii 113 (351) |+++|..|+||||||+|++...-.+..+..+...|......-....--.++|+.+|......+..--++ ..-.+++ T Consensus 5 i~ivG~~~vGKTsLi~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~i~d~~g~~~~~~~~~~~~~----~~d~~i~ 80 (166) T d1g16a_ 5 ILLIGDSGVGKSCLLVRFVEDKFNPSFITTIGIDFKIKTVDINGKKVKLQIWDTAGQERFRTITTAYYR----GAMGIIL 80 (166) T ss_dssp EEEEESTTSSHHHHHHHHHHCCCCC-------CCEEEEEEESSSCEEEEEEECCTTGGGTSCCCHHHHT----TEEEEEE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEECCCCEEEEEEECCCCCCCCCHHHHHCC----CCCEEEE T ss_conf 999807998799999998648007762445411468889987584136887205783200001243326----9968999 Q ss_pred EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCCCC Q ss_conf 87369846899999999999999999999998526953789999999984146677600111068877997121000158 Q Ver_Hs_NP_0570 114 VLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVFQD 193 (351) Q Consensus 114 vlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F~~ 193 (351) |+|++.|.++ ..++.|++.++.. ..-.+|+++||+|.|..+. T Consensus 81 v~d~~~~~s~-~~~~~~~~~i~~~-------------------------------------~~~~~piivv~nK~Dl~~~ 122 (166) T d1g16a_ 81 VYDITDERTF-TNIKQWFKTVNEH-------------------------------------ANDEAQLLLVGNKSDMETR 122 (166) T ss_dssp EEETTCHHHH-HTHHHHHHHHHHH-------------------------------------SCTTCEEEEEEECTTCTTC T ss_pred EEECCCCCHH-HHHHHHHHHHHHC-------------------------------------CCCCCCEEEEEECHHHHHC T ss_conf 9851565338-8999999998612-------------------------------------6898516667631022200 Q ss_pred CCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHH Q ss_conf 876678999999999998609468885120345678999888750 Q Ver_Hs_NP_0570 194 FESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLA 238 (351) Q Consensus 194 ~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r~r~~inhl~ 238 (351) ..+... .+.+|..+|...+.+|-... ..+..+.++++ T Consensus 123 ~v~~~e------~~~~~~~~~~~~~e~Sa~~g--~gv~~lf~~l~ 159 (166) T d1g16a_ 123 VVTADQ------GEALAKELGIPFIESSAKND--DNVNEIFFTLA 159 (166) T ss_dssp CSCHHH------HHHHHHHHTCCEEECBTTTT--BSHHHHHHHHH T ss_pred CCCHHH------HHHHHHHCCCCEEEEECCCC--CCHHHHHHHHH T ss_conf 675889------99999965993999961589--88889999999 No 93 >1i2m_A RAN, GTP-binding nuclear protein RAN; beta-propeller, G fold or GTPase fold; 1.76A {Homo sapiens} SCOP: c.37.1.8 Probab=99.27 E-value=2.5e-11 Score=94.81 Aligned_columns=151 Identities=19% Q ss_pred EEEEECCCCCHHHHHHHHCCC--CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 899865988637777755276--678887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDR--DEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r--~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |+++|..++||||||+||... .+.+.||++.||........+... ..++|+.+|-.....+....++... .+ T Consensus 13 IvivG~~~vGKTsLi~~~~~~~f~~~~~~Ti~~d~~~~~~~~~~~~~--~l~i~Dt~g~~~~~~~~~~~~~~~~----~~ 86 (216) T 1i2m_A 13 LVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLVFHTNRGPI--KFNVWDTAGQEKFGGLRDGYYIQAQ----CA 86 (216) T ss_dssp EEEEECTTSSHHHHHHTTC-----CCEEEETTEEEEEEEECBTTCCE--EEEEEECTTHHHHSSCGGGGTTTCC----EE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEECCCCCCC--CEEECCCCCCHHHHHCCHHHHCCCE----EE T ss_conf 99880799879999999863832665244045666554303688521--1122243110122101001221300----12 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) ++|+|++++.+ ++.+++|+......-..+ |+++||+|.|+. T Consensus 87 i~v~d~~~~~S-f~~i~~~~~~~~~~~~~~--------------------------------------piilvgnK~Dl~ 127 (216) T 1i2m_A 87 IIMFDVTSRVT-YKNVPNWHRDLVRVCENI--------------------------------------PIVLCGNKVDIK 127 (216) T ss_dssp EEEEETTSGGG-GTTHHHHHHHHHHHHCSC--------------------------------------CEEEEEECCCCS T ss_pred EEECCCCCCCC-HHHHHHHHHHHHHHCCCC--------------------------------------EEEEEECCCCCH T ss_conf 31102331100-133567666667623882--------------------------------------588741466520 Q ss_pred CCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHH Q ss_conf 58876678999999999998609468885120345678999888750 Q Ver_Hs_NP_0570 192 QDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLA 238 (351) Q Consensus 192 ~~~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r~r~~inhl~ 238 (351) .....+.-...++ .+|+..+.+|-... ..+..++..++ T Consensus 128 ~~~~~~~~~~~~~-------~~~~~~~e~SAk~g--~gV~e~f~~l~ 165 (216) T 1i2m_A 128 DRKVKAKSIVFHR-------KKNLQYYDISAKSN--YNFEKPFLWLA 165 (216) T ss_dssp CSCCTTTSHHHHS-------SCSSEEEEEBTTTT--BTTTHHHHHHH T ss_pred HHHHHHHHHHHHH-------HCCCCEEEEECCCC--CCHHHHHHHHH T ss_conf 2311689999999-------64896588851679--88889999999 No 94 >cd01892 Miro2 Miro2 subfamily. Miro (mitochondrial Rho) proteins have tandem GTP-binding domains separated by a linker region containing putative calcium-binding EF hand motifs. Genes encoding Miro-like proteins were found in several eukaryotic organisms. This CD represents the putative GTPase domain in the C terminus of Miro proteins. These atypical Rho GTPases have roles in mitochondrial homeostasis and apoptosis. Most Rho proteins contain a lipid modification site at the C-terminus; however, Miro is one of few Rho subfamilies that lack this feature. Probab=99.27 E-value=9e-11 Score=91.29 Aligned_columns=152 Identities=20% Q ss_pred EEEEECCCCCHHHHHHHHCCC---CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEE Q ss_conf 899865988637777755276---67888753100022111015787111788897157854202110000423512067 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDR---DEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFS 110 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r---~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~ 110 (351) |+++|+.|.|||||++||..+ ++.++||++.+|. .+...-...+-..++|..||.-...-|...-.+...+ T Consensus 7 ~~vlGd~gVGKTsll~rfv~~~F~~~~y~~Tig~~f~--~k~v~v~g~~~~l~l~Dtagqe~~~~l~~~~~~~a~~---- 80 (169) T cd01892 7 CFVLGAKGSGKSALLRAFLGRSFSLNAYSPTIKPRYA--VNTVEVYGQEKYLILREVGEDEVAILLNDAELAACDV---- 80 (169) T ss_pred EEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEE--EEEEEECCEEEEEEEECCCCHHHHHHHHHHHCCCCCE---- T ss_conf 9998089964899999985687466621152023167--9888876747899851157303454431322058878---- Q ss_pred EEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECC Q ss_conf 78887369846899999999999999999999998526953789999999984146677600111068877997121000 Q Ver_Hs_NP_0570 111 LVLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDV 190 (351) Q Consensus 111 viivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~ 190 (351) ++||.|.++|.++ +++.++..+....+. ||+++||+|.|+ T Consensus 81 ~ilVYDit~~~SF------------~~i~~~~~~~~~~~~----------------------------ipiilVGNK~DL 120 (169) T cd01892 81 ACLVYDSSDPKSF------------SYCAEVYKKYFMLGE----------------------------IPCLFVAAKADL 120 (169) T ss_pred EEEEEECCCHHHH------------HHHHHHHHHCCCCCC----------------------------CEEEEEECCCCC T ss_conf 9999867997899------------999999986048999----------------------------559998303677 Q ss_pred CCCCCHHHHHHHHHHHHHHHHHCCCEE-EEEECHHHHHHHHHHHHHHHH Q ss_conf 158876678999999999998609468-885120345678999888750 Q Ver_Hs_NP_0570 191 FQDFESEKRKVICKTLRFVAHYYGASL-MFTSKSEALLLKIRGVINQLA 238 (351) Q Consensus 191 F~~~D~e~rK~i~r~LR~iAH~yGA~L-~FtSk~e~l~~r~r~~inhl~ 238 (351) .++|.+--.-=.-+|+.+|..- +.+|-+.. .++..+-..++ T Consensus 121 -----~~~RqVs~~e~~~~a~~~g~~~~~e~SAKtg--~nV~e~F~~la 162 (169) T cd01892 121 -----DEQQQRYEVQPDEFCRKLGLPPPLHFSSKLG--DSSNELFTKLA 162 (169) T ss_pred -----CCCCCCCCCCHHHHHHHCCCCCCEEEEECCC--CCHHHHHHHHH T ss_conf -----5556336337689999629996368870179--99899999999 No 95 >1r2q_A RAS-related protein RAB-5A; GTPase, GNP, atomic resolution; HET: GNP; 1.05A {Homo sapiens} SCOP: c.37.1.8 Probab=99.27 E-value=2.3e-10 Score=88.74 Aligned_columns=162 Identities=16% Q ss_pred HHHCCCCEEEEEECCCCCHHHHHHHHCCCC--CCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECC Q ss_conf 111257458998659886377777552766--788875310002211101578711178889715785420211000042 Q Ver_Hs_NP_0570 26 GAEIAEKFVFFIGSKNGGKTTIILRCLDRD--EPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITG 103 (351) Q Consensus 26 ~~~~~ek~v~~vGsk~~GKTTli~Rfl~r~--e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~ 103 (351) |+..++--|+++|+.|+|||||++||+... +...||+..++..-.... +..+-..++|..+|......+....+. T Consensus 1 ~~~~~~yKv~viG~~~vGKTsLi~~~~~~~~~~~~~~t~~~~~~~~~~~~--~~~~~~l~i~d~~g~~~~~~~~~~~~~- 77 (170) T 1r2q_A 1 GNKICQFKLVLLGESAVGKSSLVLRFVKGQFHEFQESTIGAAFLTQTVCL--DDTTVKFEIWDTAGQERYHSLAPMYYR- 77 (170) T ss_dssp CCEEEEEEEEEECSTTSSHHHHHHHHHHSCCCTTCCCCSSEEEEEEEEEE--TTEEEEEEEEEECCSGGGGGGHHHHHT- T ss_pred CCCCCEEEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCC--CCCEEEEEEECCCCCCHHHHHHHHHHC- T ss_conf 98640378999817997789999998648015543540011100122147--884689987215563201133267523- Q ss_pred CCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEE Q ss_conf 35120677888736984689999999999999999999999852695378999999998414667760011106887799 Q Ver_Hs_NP_0570 104 DTLRTFSLVLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVI 183 (351) Q Consensus 104 ~~l~~~~viivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvI 183 (351) ....+++|+|++.|.++ +.+..|+..++.+... .+|+++ T Consensus 78 ---~~~~~i~v~d~~~~~s~-~~~~~~~~~i~~~~~~-------------------------------------~~piil 116 (170) T 1r2q_A 78 ---GAQAAIVVYDITNEESF-ARAKNWVKELQRQASP-------------------------------------NIVIAL 116 (170) T ss_dssp ---TCSEEEEEEETTCHHHH-HHHHHHHHHHHHHSCT-------------------------------------TCEEEE T ss_pred ---CCCEEEEEEECCCCCCC-HHHHHHHHHHHHHHCC-------------------------------------CCCEEE T ss_conf ---77548998405555343-0144556655332037-------------------------------------822441 Q ss_pred ECCEECCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHH Q ss_conf 7121000158876678999999999998609468885120345678999888750 Q Ver_Hs_NP_0570 184 IGSKYDVFQDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLA 238 (351) Q Consensus 184 Vg~KYD~F~~~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r~r~~inhl~ 238 (351) ||+|+|....-..+..+ .+.+|..+|+..+.+|-... ..+..+...++ T Consensus 117 vgnK~Dl~~~~~v~~~~-----~~~~a~~~~~~~~~~Sak~g--~~i~elf~~l~ 164 (170) T 1r2q_A 117 SGNKADLANKRAVDFQE-----AQSYADDNSLLFMETSAKTS--MNVNEIFMAIA 164 (170) T ss_dssp EEECGGGGGGCCSCHHH-----HHHHHHHTTCEEEECCTTTC--TTHHHHHHHHH T ss_pred CCCCCCHHHHHHHHHHH-----HHHHHHHCCCEEEEEECCCC--CCHHHHHHHHH T ss_conf 34643013343102444-----43578865962899862789--78889999999 No 96 >e2g6ba1 c.37.1.8 (A:58-227) Rab26 {Human (Homo sapiens) [TaxID:9606]} Probab=99.27 E-value=1e-10 Score=91.02 Aligned_columns=154 Identities=21% Q ss_pred EEEEECCCCCHHHHHHHHCCC---CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEE Q ss_conf 899865988637777755276---67888753100022111015787111788897157854202110000423512067 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDR---DEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFS 110 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r---~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~ 110 (351) |++||..++||||||+|++.. .+...||...++........+... ...+|+.+|......+...-++. .-. T Consensus 9 i~ivG~~~vGKTsli~~l~~~~~~~~~~~~t~~~~~~~~~~~~~~~~~--~l~i~D~~g~~~~~~~~~~~~~~----~~~ 82 (170) T e2g6ba1 9 VMLVGDSGVGKTCLLVRFKDGAFLAGTFISTVGIDFRNKVLDVDGVKV--KLQMWDTAGQERFRSVTHAYYRD----AHA 82 (170) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEEECCEEE--EEEEEECCCCCHHHHHHHHHHCC----CCE T ss_conf 999826997789999998648326774243010010157898889789--99997347841011210445258----717 Q ss_pred EEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECC Q ss_conf 78887369846899999999999999999999998526953789999999984146677600111068877997121000 Q Ver_Hs_NP_0570 111 LVLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDV 190 (351) Q Consensus 111 viivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~ 190 (351) +++|+|++.+.++ ..++.|+..++..... .+|+++||+|+|. T Consensus 83 ~i~v~d~~~~~s~-~~~~~~~~~i~~~~~~-------------------------------------~~p~iiv~nK~Dl 124 (170) T e2g6ba1 83 LLLLYDVTNKASF-DNIQAWLTEIHEYAQH-------------------------------------DVALMLLGNKVDS 124 (170) T ss_pred EEEEEECCCHHHH-HHHHHHHHHHHHCCCC-------------------------------------CCEEEEEEECCCH T ss_conf 8998505520358-8761115788621588-------------------------------------7057753210000 Q ss_pred CCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHH Q ss_conf 158876678999999999998609468885120345678999888750 Q Ver_Hs_NP_0570 191 FQDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLA 238 (351) Q Consensus 191 F~~~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r~r~~inhl~ 238 (351) .+.+.+....++.++..+|+..+.+|-... ..+..+...++ T Consensus 125 -----~~~~~v~~~~~~~~~~~~~~~~~e~Sak~g--~gI~elf~~i~ 165 (170) T e2g6ba1 125 -----AHERVVKREDGEKLAKEYGLPFMETSAKTG--LNVDLAFTAIA 165 (170) T ss_pred -----HHHCCCCHHHHHHHHHHCCCCEEEEECCCC--CCHHHHHHHHH T ss_conf -----010155778999999965992899972689--88889999999 No 97 >d1c1ya_ c.37.1.8 (A:) Rap1A {Human (Homo sapiens)} Probab=99.27 E-value=1.3e-10 Score=90.36 Aligned_columns=154 Identities=17% Q ss_pred EEEEECCCCCHHHHHHHHC--CCCCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 8998659886377777552--76678887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCL--DRDEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl--~r~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |+++|+.++||||||+|++ .-.+...||.+-.| ++.-..+...-..++|+.+|-.....+-...++.-. .+ T Consensus 6 i~iiG~~~vGKTsLi~~~~~~~~~~~~~~t~~~~~---~~~~~~~~~~~~~~~~D~~g~~~~~~~~~~~~~~~~----~~ 78 (167) T d1c1ya_ 6 LVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSY---RKQVEVDCQQCMLEILDTAGTEQFTAMRDLYMKNGQ----GF 78 (167) T ss_dssp EEEECSTTSSHHHHHHHHHHCCCCCSCCCCSEEEE---EEEEESSSCEEEEEEEEECSSCSSTTHHHHHHHHCS----EE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCEEE---EEEEEECCEEEEEEEEECCCCCHHHHHHHHHHCCCC----EE T ss_conf 99981799878999999862733554564002026---889987141456777622566302355576506886----89 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) ++|+|++.+.. |++++.|+.....+... ..+|+++||+|+|. T Consensus 79 i~v~d~~~~~s-~~~~~~~~~~~~~~~~~------------------------------------~~~piilvgnK~Dl- 120 (167) T d1c1ya_ 79 ALVYSITAQST-FNDLQDLREQILRVKDT------------------------------------EDVPMILVGNKCDL- 120 (167) T ss_dssp EEEEETTCHHH-HHTHHHHHHHHHHHHCC------------------------------------SCCCEEEEEECTTC- T ss_pred EEEECCCCCCC-HHHHHHHHHHHHHHCCC------------------------------------CCEEEEEEEECCCC- T ss_conf 99830676642-68899999999975068------------------------------------97089998504780- Q ss_pred CCCCHHHHHHHHHHHHHHHHHCCCEEEE-EECHHHHHHHHHHHHHHHH Q ss_conf 5887667899999999999860946888-5120345678999888750 Q Ver_Hs_NP_0570 192 QDFESEKRKVICKTLRFVAHYYGASLMF-TSKSEALLLKIRGVINQLA 238 (351) Q Consensus 192 ~~~D~e~rK~i~r~LR~iAH~yGA~L~F-tSk~e~l~~r~r~~inhl~ 238 (351) .+.|.+...-.+.+|-.++...+| +|-... ..+..+...++ T Consensus 121 ----~~~~~v~~~e~~~~~~~~~~~~~~e~Sak~~--~~v~elf~~l~ 162 (167) T d1c1ya_ 121 ----EDERVVGKEQGQNLARQWCNCAFLESSAKSK--INVNEIFYDLV 162 (167) T ss_dssp ----GGGCCSCHHHHHHHHHHTTSCEEEECBTTTT--BSHHHHHHHHH T ss_pred ----CCCCCCCHHHHHHHHHHHCCCEEEEEECCCC--CCHHHHHHHHH T ss_conf ----0014789899999999844970788850589--88889999999 No 98 >d1r2qa_ c.37.1.8 (A:) Rab5a {Human (Homo sapiens)} SCOP: d1n6oa_ d1tu4a_ d1n6la_ d1tu4d_ d1n6ka_ d1n6ha_ d1tu3c_ d1tu3b_ d1n6na_ d1n6ra_ d1tu4b_ d1n6pa_ d1tu3d_ u1z0da1 d1huqa_ u1z07a1 Probab=99.27 E-value=1.1e-10 Score=90.85 Aligned_columns=162 Identities=19% Q ss_pred HHHCCCCEEEEEECCCCCHHHHHHHHC--CCCCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECC Q ss_conf 111257458998659886377777552--766788875310002211101578711178889715785420211000042 Q Ver_Hs_NP_0570 26 GAEIAEKFVFFIGSKNGGKTTIILRCL--DRDEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITG 103 (351) Q Consensus 26 ~~~~~ek~v~~vGsk~~GKTTli~Rfl--~r~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~ 103 (351) |+-.+.--|++||..|+||||||+||+ +-.+.+.||...+|........+... ..++|+.+|...+..+....+.. T Consensus 1 ~~~~~~~Ki~ivG~~~vGKTsli~~~~~~~~~~~~~~t~~~~~~~~~~~~~~~~~--~~~i~D~~g~~~~~~~~~~~~~~ 78 (170) T d1r2qa_ 1 GNKICQFKLVLLGESAVGKSSLVLRFVKGQFHEFQESTIGAAFLTQTVCLDDTTV--KFEIWDTAGQERYHSLAPMYYRG 78 (170) T ss_dssp CCEEEEEEEEEECSTTSSHHHHHHHHHHSCCCTTCCCCSSEEEEEEEEEETTEEE--EEEEEEECCSGGGGGGHHHHHTT T ss_pred CCCCCEEEEEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEEECCEEE--EEEEECCCCCHHHHHHHHHHCCC T ss_conf 9875226899982799779999999864812556353035677776565569079--99874277730344541210268 Q ss_pred CCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEE Q ss_conf 35120677888736984689999999999999999999999852695378999999998414667760011106887799 Q Ver_Hs_NP_0570 104 DTLRTFSLVLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVI 183 (351) Q Consensus 104 ~~l~~~~viivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvI 183 (351) . -.+++|+|++.+.++ +.++.|+....+.... .+|+++ T Consensus 79 ~----~~~i~v~d~~~~~s~-~~~~~~~~~~~~~~~~-------------------------------------~~piil 116 (170) T d1r2qa_ 79 A----QAAIVVYDITNEESF-ARAKNWVKELQRQASP-------------------------------------NIVIAL 116 (170) T ss_dssp C----SEEEEEEETTCHHHH-HHHHHHHHHHHHHSCT-------------------------------------TCEEEE T ss_pred C----CEEEEEEECCCHHHH-HHHHHHHHHHHHHHHC-------------------------------------CCCEEE T ss_conf 8----679998306520358-8898889999886405-------------------------------------861244 Q ss_pred ECCEECCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHH Q ss_conf 7121000158876678999999999998609468885120345678999888750 Q Ver_Hs_NP_0570 184 IGSKYDVFQDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLA 238 (351) Q Consensus 184 Vg~KYD~F~~~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r~r~~inhl~ 238 (351) ||+|+|. .+.+.+...-++.+|..+++.++++|-... ..+..+...++ T Consensus 117 v~nK~Dl-----~~~~~i~~~~~~~~~~~~~~~~~e~Sak~g--~gi~elf~~i~ 164 (170) T d1r2qa_ 117 SGNKADL-----ANKRAVDFQEAQSYADDNSLLFMETSAKTS--MNVNEIFMAIA 164 (170) T ss_dssp EEECGGG-----GGGCCSCHHHHHHHHHHTTCEEEECCTTTC--TTHHHHHHHHH T ss_pred EECCHHH-----HHHCCCCHHHHHHHHHHCCCEEEEEECCCC--CCHHHHHHHHH T ss_conf 3032110-----100365878999999855983999861689--78889999999 No 99 >2p5s_A RAS and EF-hand domain containing; G-protein, RAB, GDP, structural genomics, SGC, structural genomics consortium; HET: GDP; 2.15A {Homo sapiens} Probab=99.26 E-value=2.4e-11 Score=94.93 Aligned_columns=161 Identities=17% Q ss_pred EEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEEEE Q ss_conf 89986598863777775527667888753100022111015787111788897157854202110000423512067788 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDRDEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSLVL 113 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~vii 113 (351) |+++|..|+||||||+|+....-.......+...|..+....+...-..++|+.+|-.....+.+..+.... .+++ T Consensus 31 I~ivG~~~vGKSsLi~~l~~~~~~~~~~~t~~~~~~~~~i~~~~~~~~l~i~d~~~~~~~~~~~~~~~~~~d----~~il 106 (199) T 2p5s_A 31 IVLAGDAAVGKSSFLMRLCKNEFRENISATLGVDFQMKTLIVDGERTVLQLWDTAGQERFRSIAKSYFRKAD----GVLL 106 (199) T ss_dssp EEEESSTTSSHHHHHHHHHHCCCC----------CEEEEEEETTEEEEEEEEECTTCTTCHHHHHHHHHHCS----EEEE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEEECCCEEEEEEECCCCHHHHHHHHHHHHHHHC----CEEE T ss_conf 999807998799999998658125651454024678888741562145642025412455678898753300----2243 Q ss_pred EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCCCC Q ss_conf 87369846899999999999999999999998526953789999999984146677600111068877997121000158 Q Ver_Hs_NP_0570 114 VLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVFQD 193 (351) Q Consensus 114 vlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F~~ 193 (351) |+|++.|..+.. +++|+..++....+ .+|++|||+|.|.... T Consensus 107 v~d~~~~~s~~~-~~~~~~~i~~~~~~-------------------------------------~~Piiiv~nK~Dl~~~ 148 (199) T 2p5s_A 107 LYDVTCEKSFLN-IREWVDMIEDAAHE-------------------------------------TVPIMLVGNKADIRDT 148 (199) T ss_dssp EEETTCHHHHHT-HHHHHHHHHHHC----------------------------------------CCEEEEEECGGGHHH T ss_pred EEHHCCHHHHHH-HHCCCCCCCCCCCC-------------------------------------CCEEEEEECCCCHHHH T ss_conf 200102023333-21000121113689-------------------------------------7279882112560234 Q ss_pred CCHHHHHHHHHHH-HHHHHHCCCEEEEEECHHHHHHHHHHHHHHHH Q ss_conf 8766789999999-99998609468885120345678999888750 Q Ver_Hs_NP_0570 194 FESEKRKVICKTL-RFVAHYYGASLMFTSKSEALLLKIRGVINQLA 238 (351) Q Consensus 194 ~D~e~rK~i~r~L-R~iAH~yGA~L~FtSk~e~l~~r~r~~inhl~ 238 (351) -..+..+.+.... +.+|-.+|+..+++|-... ..+..++..++ T Consensus 149 ~~~~~~~~i~~~~~~~~a~~~~~~~~~~Sak~g--~gi~e~f~~i~ 192 (199) T 2p5s_A 149 AATEGQKCVPGHFGEKLAMTYGALFCETSAKDG--SNIVEAVLHLA 192 (199) T ss_dssp HHHTTCCCCCHHHHHHHHHHHTCEEEECCTTTC--TTHHHHHHHHH T ss_pred HHHHHHHCCCHHHHHHHHHHCCCEEEEEECCCC--CCHHHHHHHHH T ss_conf 444443134688999999855986999852579--88899999999 No 100 >smart00173 RAS Ras subfamily of RAS small GTPases; Similar in fold and function to the bacterial EF-Tu GTPase. p21Ras couples receptor Tyr kinases and G protein receptors to protein kinase cascades Probab=99.26 E-value=1.9e-10 Score=89.22 Aligned_columns=154 Identities=18% Q ss_pred EEEEECCCCCHHHHHHHHCCC--CCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEEECCCCCHHHCEEEEECCCCCCEEEE Q ss_conf 899865988637777755276--678887531000221110157871117888971578542021100004235120677 Q Ver_Hs_NP_0570 34 VFFIGSKNGGKTTIILRCLDR--DEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSL 111 (351) Q Consensus 34 v~~vGsk~~GKTTli~Rfl~r--~e~~KPTlALeYtygRra~~~~~~KdvaH~WELGgg~~ls~Li~ipit~~~l~~~~v 111 (351) |++||+.+.||||||.||++. .+.+.||++-.|+---..++..- ..++|..+|.-.+..|...-++..+ .+ T Consensus 5 iiliGd~~vGKTsli~r~~~~~f~~~y~~ti~~~~~k~~~i~~~~~---~l~iwDtaG~e~~~~~~~~~~~~a~----~~ 77 (166) T smart00173 5 LVVLGSGGVGKSALTIQFVQGIFVDDYDPTIEDSYRKQIEIDGEVC---LLDILDTAGQEEFSAMRDQYMRTGE----GF 77 (166) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCEEE---EEEEEECCCCCCHHHHHHHHHCCCC----CE T ss_conf 9998079964899999987280277545521212257898989799---9998627998512367788740799----35 Q ss_pred EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCEECCC Q ss_conf 88873698468999999999999999999999985269537899999999841466776001110688779971210001 Q Ver_Hs_NP_0570 112 VLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVF 191 (351) Q Consensus 112 iivlDlSkP~~lw~tle~~l~~vr~~v~kl~~~l~k~~~~~~~~l~qra~~~~~~dhpD~~~v~p~piPlvIVg~KYD~F 191 (351) +||.|++.+.++=.--.+| +.+.+.....+ +|++|||+|.|. T Consensus 78 iivydit~~~Sf~~~~~w~--------~~i~~~~~~~~-----------------------------ip~vlvgNK~Dl- 119 (166) T smart00173 78 LLVYSITDRQSFEEIKKFR--------EQILRVKDRDD-----------------------------VPIVLVGNKCDL- 119 (166) T ss_pred EEEEECCCHHHHHHHHHHH--------HHHHHHCCCCC-----------------------------CEEEEEECCCCC- T ss_conf 9999749978999998998--------99987428999-----------------------------579998114651- Q ss_pred CCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHH Q ss_conf 58876678999999999998609468885120345678999888750 Q Ver_Hs_NP_0570 192 QDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLA 238 (351) Q Consensus 192 ~~~D~e~rK~i~r~LR~iAH~yGA~L~FtSk~e~l~~r~r~~inhl~ 238 (351) +++|.+.-.-..-+|..+|+..+.+|-+.. ..+..+..+++ T Consensus 120 ----~~~r~v~~~~~~~~a~~~~~~~~E~SAk~~--~nV~e~F~~l~ 160 (166) T smart00173 120 ----ENERQVSTEEGKELARQWNCPFLETSAKER--INVDEAFYDLV 160 (166) T ss_pred ----CCCCCCCHHHHHHHHHHCCCCEEEEECCCC--CCHHHHHHHHH T ss_conf ----000457678999999966996999972589--88889999999 Done!