Query Ver_Hs_NP_006132.1_LIC2 Command /cluster/toolkit/production/bioprogs/hhpred/hhsearch -cal -cpu 4 -v 1 -i /cluster/toolkit/production/tmp/production/96148/Hs_NP_006132.hhm -d /cluster/toolkit/production/databases/hhpred/new_dbs/pdb70_3Jan08/db/pdb.hhm /cluster/toolkit/production/databases/hhpred/new_dbs/scop70_1.72pre/db/scop.hhm /cluster/toolkit/production/databases/hhpred/new_dbs/scop70_1.71/db/scop.hhm /cluster/toolkit/production/databases/hhpred/new_dbs/pfamA_22.0/db/pfamA.hhm /cluster/toolkit/production/databases/hhpred/new_dbs/smart_18Apr07/db/smart.hhm /cluster/toolkit/production/databases/hhpred/new_dbs/pfam_18Apr07/db//pfam.hhm /cluster/toolkit/production/databases/hhpred/new_dbs/KOG_18Apr07/db/KOG.hhm /cluster/toolkit/production/databases/hhpred/new_dbs/COG_18Apr07/db/COG.hhm /cluster/toolkit/production/databases/hhpred/new_dbs/cd_18Apr07/db/cd.hhm /cluster/toolkit/production/databases/hhpred/new_dbs/panther_13Dec06/db/panther.hmm /cluster/toolkit/production/databases/hhpred/new_dbs/tigrfam_13Dec06/db/tigrfam.hmm /cluster/toolkit/production/databases/hhpred/new_dbs/pirsf_13Dec06/db/pirsf.hmm /cluster/toolkit/production/databases/hhpred/new_dbs/supfam_13Dec06/db/supfam.hmm /cluster/toolkit/production/databases/hhpred/new_dbs/CATH_13Dec06/db/CATH.hmm -o /cluster/toolkit/production/tmp/production/96148/Hs_NP_006132.hhr -p 20 -P 20 -Z 100 -B 100 -seq 1 -aliw 80 -local -ssm 2 -norealign -sc 1 No Hit Prob E-value P-value Score SS Cols Query HMM Template HMM 1 pfam05783 DLIC Dynein light in 100.0 0 0 1343.8 39.8 474 8-490 1-475 (475) 2 PF05783 DLIC: Dynein light in 100.0 0 0 1307.0 40.2 482 9-490 2-525 (525) 3 KOG3905 Dynein light intermedi 100.0 0 0 1279.6 36.5 472 3-492 1-473 (473) 4 PTHR12688 DYNEIN LIGHT INTERME 100.0 0 0 982.4 23.9 401 85-491 1-402 (415) 5 PTHR13236 DYNEIN 2 LIGHT INTER 99.9 8.7E-25 9.1E-30 188.7 10.3 281 33-321 13-305 (397) 6 KOG3929 Uncharacterized conser 99.9 1.2E-21 1.2E-26 167.7 8.4 246 24-322 27-282 (363) 7 2q3h_A RAS homolog gene family 99.2 8.8E-10 9.2E-15 88.1 10.5 185 42-292 6-194 (201) 8 cd04128 Spg1 Spg1p. Spg1p (se 99.1 1.8E-08 1.9E-13 79.3 14.5 177 57-308 3-182 (182) 9 2hxs_A RAB-26, RAS-related pro 99.0 4.7E-08 4.9E-13 76.6 14.4 167 56-297 8-177 (178) 10 e1z2aa_ c.37.1.8 (A:) Rab23 {M 99.0 7.6E-09 8E-14 81.8 10.4 157 56-292 4-163 (164) 11 d3raba_ c.37.1.8 (A:) Rab3a {R 99.0 2.5E-08 2.6E-13 78.4 12.2 157 57-292 8-167 (169) 12 e2gjsa1 c.37.1.8 (A:91-258) Ra 99.0 2.3E-08 2.4E-13 78.6 12.0 159 57-292 4-162 (168) 13 2atx_A Small GTP binding prote 99.0 1.8E-08 1.9E-13 79.3 11.3 182 46-293 5-193 (194) 14 1oix_A RAS-related protein RAB 99.0 1.1E-07 1.2E-12 74.0 15.2 159 57-292 32-191 (191) 15 1ek0_A GTP-binding protein YPT 99.0 6.2E-08 6.5E-13 75.8 13.6 162 56-291 5-167 (170) 16 e1xtqa1 c.37.1.8 (A:3-169) GTP 99.0 4.4E-08 4.6E-13 76.7 12.5 159 57-291 7-165 (167) 17 2oil_A CATX-8, RAS-related pro 99.0 3.4E-08 3.5E-13 77.5 11.4 170 46-292 10-187 (193) 18 1x3s_A RAS-related protein RAB 99.0 1.3E-07 1.3E-12 73.6 14.4 160 56-292 17-177 (195) 19 2fg5_A RAB-22B, RAS-related pr 99.0 6.7E-08 7E-13 75.5 12.5 156 57-291 26-184 (192) 20 2p5s_A RAS and EF-hand domain 99.0 6.4E-09 6.7E-14 82.4 7.3 164 57-291 31-195 (199) 21 e2erxa1 c.37.1.8 (A:6-176) di- 98.9 1.2E-07 1.2E-12 73.9 13.6 159 56-289 4-162 (171) 22 e2a5ja1 c.37.1.8 (A:9-181) Rab 98.9 1.3E-07 1.3E-12 73.6 12.8 159 57-292 6-165 (173) 23 d1g16a_ c.37.1.8 (A:) Rab-rela 98.9 2.2E-07 2.3E-12 72.1 14.0 159 56-292 4-163 (166) 24 e2atxa1 c.37.1.8 (A:9-193) Rho 98.9 1E-07 1.1E-12 74.3 12.2 172 56-293 11-184 (185) 25 cd00154 Rab Rab family. Rab G 98.9 1.2E-07 1.2E-12 73.9 12.3 152 57-287 3-157 (159) 26 1xtq_A GTP-binding protein RHE 98.9 7.4E-07 7.7E-12 68.5 16.3 157 57-292 9-168 (177) 27 e1x3sa1 c.37.1.8 (A:2-178) Rab 98.9 1.9E-07 2E-12 72.5 13.1 169 50-296 4-173 (177) 28 1x1r_A RAS-related protein M-R 98.9 4.6E-07 4.8E-12 69.9 14.9 157 57-292 16-176 (178) 29 2j1l_A RHO-related GTP-binding 98.9 4.5E-08 4.7E-13 76.7 9.8 170 57-292 37-208 (214) 30 d1r2qa_ c.37.1.8 (A:) Rab5a {H 98.9 1.8E-07 1.9E-12 72.7 12.8 159 57-292 9-168 (170) 31 d1r2qa_ c.37.1.8 (A:) Rab5a {H 98.9 1.5E-07 1.6E-12 73.1 12.3 160 56-292 8-168 (170) 32 2fn4_A P23, RAS-related protei 98.9 4.8E-07 5E-12 69.8 14.8 160 57-292 12-171 (181) 33 d1oiva_ c.37.1.8 (A:) Rab11a { 98.9 2.7E-07 2.9E-12 71.4 13.5 159 57-292 9-168 (168) 34 cd00877 Ran Ran (Ras-related n 98.9 3E-07 3.1E-12 71.1 13.6 157 57-295 3-162 (166) 35 cd04101 RabL4 RabL4 (Rab-like4 98.9 2.4E-07 2.5E-12 71.8 13.1 157 57-292 3-164 (164) 36 1r2q_A RAS-related protein RAB 98.9 5.4E-07 5.7E-12 69.4 14.9 158 57-291 9-167 (170) 37 cd04119 RJL RJL (RabJ-Like) su 98.9 3.8E-07 4E-12 70.5 14.0 163 57-293 3-168 (168) 38 1i2m_A RAN, GTP-binding nuclea 98.9 9.6E-08 1E-12 74.5 10.6 157 57-295 13-172 (216) 39 2bov_A RAla, RAS-related prote 98.9 1.1E-07 1.1E-12 74.1 10.9 160 57-292 17-176 (206) 40 2gf9_A RAS-related protein RAB 98.9 1.5E-06 1.5E-11 66.5 16.6 171 45-292 9-184 (189) 41 2dpx_A GTP-binding protein RAD 98.9 7.6E-08 8E-13 75.1 10.0 159 57-292 10-168 (174) 42 pfam00071 Ras Ras family. Incl 98.9 2.6E-07 2.7E-12 71.5 12.7 159 57-292 2-161 (162) 43 cd01863 Rab18 Rab18 subfamily. 98.9 2.6E-07 2.8E-12 71.5 12.6 156 57-291 3-161 (161) 44 e1x1ra1 c.37.1.8 (A:10-178) Ra 98.9 1.5E-07 1.6E-12 73.2 11.3 164 51-291 2-166 (169) 45 d1wmsa_ c.37.1.8 (A:) Rab9a {H 98.9 9.3E-07 9.7E-12 67.9 15.4 160 57-292 9-172 (174) 46 1wms_A RAB-9, RAB9, RAS-relate 98.8 4.4E-07 4.6E-12 70.0 13.7 162 57-292 10-173 (177) 47 e1z0fa_ c.37.1.8 (A:) Rab14 {H 98.8 3.5E-07 3.7E-12 70.7 13.1 159 57-292 8-167 (167) 48 cd01866 Rab2 Rab2 subfamily. 98.8 5.8E-07 6.1E-12 69.2 14.1 157 57-292 7-166 (168) 49 cd00876 Ras Ras family. The R 98.8 2.1E-07 2.2E-12 72.2 11.7 159 57-291 2-160 (160) 50 1z08_A RAS-related protein RAB 98.8 2.6E-06 2.8E-11 64.8 17.3 159 57-292 9-168 (170) 51 e1z08a1 c.37.1.8 (A:17-183) Ra 98.8 1.4E-07 1.4E-12 73.5 10.7 157 57-292 6-165 (167) 52 1m7b_A RND3/RHOE small GTP-bin 98.8 2.3E-07 2.5E-12 71.9 11.8 171 57-293 10-183 (184) 53 1c1y_A RAS-related protein RAP 98.8 9.5E-07 9.9E-12 67.8 14.8 160 57-292 6-166 (167) 54 e2f7sa1 c.37.1.8 (A:5-190) Rab 98.8 3.4E-07 3.6E-12 70.8 12.5 160 57-292 8-178 (186) 55 1z2a_A RAS-related protein RAB 98.8 8.7E-07 9.1E-12 68.1 14.6 156 57-292 8-166 (168) 56 d1d5ca_ c.37.1.8 (A:) Rab6 {Ma 98.8 2.7E-07 2.9E-12 71.4 11.9 156 57-291 4-162 (162) 57 2f9l_A RAB11B, member RAS onco 98.8 9.2E-07 9.6E-12 67.9 14.6 159 57-292 8-167 (199) 58 1yzq_A Small GTP binding prote 98.8 4.7E-07 4.9E-12 69.8 13.0 161 57-294 9-170 (170) 59 cd01868 Rab11_like Rab11-like. 98.8 3.4E-07 3.5E-12 70.8 12.2 159 57-292 6-165 (165) 60 2pmx_A K-RAS; cancer, small GT 98.8 4.1E-07 4.3E-12 70.3 12.6 159 57-292 24-182 (187) 61 1z0f_A RAB14, member RAS oncog 98.8 1.8E-07 1.9E-12 72.7 10.7 167 47-292 4-177 (179) 62 1z0j_A RAB-22, RAS-related pro 98.8 1.5E-06 1.5E-11 66.6 15.4 159 56-291 8-167 (170) 63 cd04122 Rab14 Rab14 subfamily. 98.8 4.4E-07 4.6E-12 70.0 12.5 159 57-292 5-164 (166) 64 1vg8_A RAS-related protein RAB 98.8 1.8E-06 1.9E-11 65.9 15.6 162 56-292 10-174 (207) 65 cd04106 Rab23_lke Rab23-like s 98.8 3.4E-07 3.6E-12 70.8 11.7 156 57-290 3-161 (162) 66 2g3y_A GTP-binding protein GEM 98.8 5.8E-07 6.1E-12 69.2 12.9 180 33-292 16-202 (211) 67 2rex_B RHO-related GTP-binding 98.8 4.5E-07 4.7E-12 70.0 12.2 170 57-301 13-194 (197) 68 e2ew1a1 c.37.1.8 (A:4-174) Rab 98.8 5.3E-07 5.5E-12 69.5 12.4 160 57-293 8-168 (171) 69 cd04115 Rab33B_Rab33A Rab33B/R 98.8 5.7E-07 6E-12 69.3 12.4 157 57-291 5-168 (170) 70 d1m7ba_ c.37.1.8 (A:) RhoE (RN 98.8 8.8E-07 9.2E-12 68.0 13.3 162 57-288 5-173 (179) 71 cd04109 Rab28 Rab28 subfamily. 98.8 6.3E-07 6.6E-12 69.0 12.5 170 57-301 3-175 (215) 72 cd04124 RabL2 RabL2 subfamily. 98.8 9.7E-07 1E-11 67.7 13.5 157 57-294 3-160 (161) 73 1u8z_A RAS-related protein RAL 98.8 2.6E-07 2.8E-12 71.5 10.5 160 57-292 7-166 (168) 74 d1ek0a_ c.37.1.8 (A:) Ypt51 {B 98.8 1.2E-06 1.2E-11 67.2 13.7 160 56-291 5-167 (170) 75 d1kmqa_ c.37.1.8 (A:) RhoA {Hu 98.8 1.4E-06 1.5E-11 66.7 14.1 164 55-288 3-172 (177) 76 2ce2_X GTPase HRAS; guanine nu 98.8 1.4E-06 1.5E-11 66.6 14.0 158 57-292 6-164 (166) 77 cd04108 Rab36_Rab34 Rab34/Rab3 98.8 5.5E-07 5.8E-12 69.4 11.8 161 57-294 3-167 (170) 78 PF00071 Ras: Ras family; Int 98.8 1.5E-06 1.5E-11 66.6 13.8 160 57-292 2-173 (174) 79 2fv8_A H6, RHO-related GTP-bin 98.8 1.3E-06 1.3E-11 67.0 13.4 166 57-292 28-199 (207) 80 d1c1ya_ c.37.1.8 (A:) Rap1A {H 98.8 2.3E-06 2.4E-11 65.2 14.8 160 56-291 5-165 (167) 81 2a9k_A RAS-related protein RAL 98.8 1.3E-06 1.4E-11 66.8 13.5 179 37-292 2-180 (187) 82 2gco_A H9, RHO-related GTP-bin 98.7 5.3E-07 5.5E-12 69.5 11.4 182 45-292 9-199 (201) 83 1zbd_A Rabphilin-3A; G protein 98.7 2.6E-06 2.7E-11 64.9 14.8 157 57-292 11-170 (203) 84 e2atva1 c.37.1.8 (A:5-172) Ras 98.7 1.7E-06 1.8E-11 66.1 13.8 160 56-292 4-164 (168) 85 2nzj_A GTP-binding protein REM 98.7 5.3E-07 5.5E-12 69.5 11.0 159 57-292 7-168 (175) 86 cd04139 RalA_RalB RalA/RalB su 98.7 1.1E-06 1.1E-11 67.4 12.6 157 57-292 3-162 (164) 87 d1wmsa_ c.37.1.8 (A:) Rab9a {H 98.7 2.7E-06 2.8E-11 64.7 14.5 160 57-292 9-172 (174) 88 cd04123 Rab21 Rab21 subfamily. 98.7 9.4E-07 9.9E-12 67.8 12.1 159 57-292 3-162 (162) 89 cd04127 Rab27A Rab27a subfamil 98.7 1.7E-06 1.8E-11 66.1 13.3 160 57-292 7-177 (180) 90 2a5j_A RAS-related protein RAB 98.7 1.1E-06 1.2E-11 67.3 12.3 175 37-292 3-183 (191) 91 e2f9la1 c.37.1.8 (A:8-182) Rab 98.7 4.8E-07 5E-12 69.8 10.4 159 57-292 7-166 (175) 92 2atv_A RERG, RAS-like estrogen 98.7 1.9E-06 2E-11 65.7 13.4 159 57-292 31-190 (196) 93 d1ky3a_ c.37.1.8 (A:) Rab-rela 98.7 4E-06 4.2E-11 63.6 15.0 165 56-292 4-171 (175) 94 d1m7ba_ c.37.1.8 (A:) RhoE (RN 98.7 9.2E-07 9.6E-12 67.9 11.7 166 57-288 5-173 (179) 95 cd04113 Rab4 Rab4 subfamily. 98.7 9.3E-07 9.7E-12 67.9 11.6 158 57-291 3-161 (161) 96 d1ukvy_ c.37.1.8 (Y:) GTPase Y 98.7 9.2E-07 9.6E-12 67.9 11.4 156 57-291 9-167 (204) 97 1kao RAP2A; GTP-binding prot 98.7 1.9E-06 2E-11 65.7 13.1 159 57-291 6-164 (167) 98 2bcg_Y Protein YP2, GTP-bindin 98.7 1.2E-06 1.3E-11 67.1 12.0 159 57-292 11-170 (206) 99 1gwn_A RHO-related GTP-binding 98.7 7.2E-07 7.6E-12 68.6 10.9 186 41-293 12-204 (205) 100 d1i2ma_ c.37.1.8 (A:) Ran {Hum 98.7 7.5E-07 7.8E-12 68.5 10.9 159 57-295 6-165 (170) No 1 >pfam05783 DLIC Dynein light intermediate chain (DLIC). This family consists of several eukaryotic dynein light intermediate chain proteins. The light intermediate chains (LICs) of cytoplasmic dynein consist of multiple isoforms, which undergo post-translational modification to produce a large number of species. DLIC1 is known to be involved in assembly, organisation, and function of centrosomes and mitotic spindles when bound to pericentrin. DLIC2 is a subunit of cytoplasmic dynein 2 that may play a role in maintaining Golgi organisation by binding cytoplasmic dynein 2 to its Golgi-associated cargo. Probab=100.00 E-value=0 Score=1343.80 Aligned_columns=474 Identities=72% Q ss_pred CEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCE Q ss_conf 20234588764235654456743440689999999981786227887648886078854899999862013367874310 Q Ver_Hs_NP_0061 8 KKLLLGPNGPAVAAAGDLTSEEEEGQSLWSSILSEVSTRARSKLPSGKNILVFGEDGSGKTTLMTKLQGAEHGKKGRGLE 87 (492) Q Consensus 8 ~~~~~~~~~~~~~~~~~~~~~~~~~~~lWssil~eV~~~~~~klp~~KnILvLG~~~sGKttLi~~Lq~~e~~kkg~gLe 87 (492) .+...++|+++++..|+...+++++||||||||+||++++|+|||+||||||||++++|||||+++||++++.+||+||| T Consensus 1 ~~~~~~~n~~~~~~~~~~~~~~~~k~nLWsSIL~~V~t~~r~Klp~~KniLVLG~~~~GKttLl~~Lqg~~~~kkg~aL~ 80 (475) T pfam05783 1 LESGDTANALASVFTGKLYSSTEEGQNLWSEILSEVSTRTRSKLPSGKNVLVLGDNGSGKTSLISRLQGSERTKKGRGLE 80 (475) T ss_pred CCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCC T ss_conf 98762012333320267777410122478988865302533347776647885089975578999750577667863101 Q ss_pred EEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCH Q ss_conf 33530212134730010058856760211353224773433021020002120324799999999999999997248888 Q Ver_Hs_NP_0061 88 YLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLVIFVADMSRPWTVMESLQKWASVLREHIDKMKIPP 167 (492) Q Consensus 88 Y~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlVvI~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~ 167 (492) |+|+||+|+||||++|||||||||++||++||||++|++||+|||||||||||+||+||+|||+|++|||+|+++|++++ T Consensus 81 Y~YldV~DeD~Dd~~R~~vwiLd~~~~~~~LLK~aL~~~si~~TlViI~lDms~PW~~i~qL~~Wi~VLrehi~~L~i~~ 160 (475) T pfam05783 81 YLYLHVHDEDRDDLTRCNVWILDGDLYHKGLLKFALPATSLAETLVILTASMSNPWTLLESLQKWASVLREHIDKLKIPP 160 (475) T ss_pred EEEECCCCCCHHHHCCCCEEECCCCCCCCCCCCCCCCCCCHHHHHEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH T ss_conf 34632322030322154247608751522232125772314220120012120134899999999999999997138998 Q ss_pred HHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCCCCCCCEECCCCCEEEEEEECCCHHHHHHHCCCCC Q ss_conf 99999999999998620350005777767664545665400003688876221479940799850752255554205774 Q Ver_Hs_NP_0061 168 EKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLGDNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYR 247 (492) Q Consensus 168 e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lPLgeg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~ 247 (492) |++++|+++++++||+|+||+++++++++|+++..++.++++|.+|||||+||+||||||||||||||+|++|||||+|+ T Consensus 161 ee~~el~e~l~~~wqeY~epg~~~d~s~~r~t~~~~~~~~~~v~lPLgeg~Lt~NLGiPiiVVctKsD~ie~LEKe~~yk 240 (475) T pfam05783 161 EEMKAGRQKLEKDWQEYVEPGEDLDGSPQRRTSVVGSFDEEHVLLPLGQDTLTHNLGLPVLVVCTKCDAMSVLEKEHDYR 240 (475) T ss_pred HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCEEEEEEEECCCHHHHHHCCCCCC T ss_conf 89999999999999986055346787763245665653444565778876341278826999861762133332015664 Q ss_pred HHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCEEEECCCCCCHHHHHHHHHCC Q ss_conf 77899999999999987087378845666356799999998887277767655033112145368888378899876055 Q Ver_Hs_NP_0061 248 DEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTYGFHFTTPALVVEKDAVFIPAGWDNEKKIAILHENF 327 (492) Q Consensus 248 dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~Hrlygfpf~~ka~VvdkD~IfIPaGWDs~~KI~Il~Enf 327 (492) ||||||||||||||||+|||||||||+|+++||+||||||+||+|||||+++|+|+|||+|||||||||||||+|||||| T Consensus 241 eE~fDfIqq~LR~~cLqYGAsLiYTS~ke~kNldlLykYl~HrlYgfpf~~~a~VvekDaIfIPsGWDn~kKI~Il~Enf 320 (475) T pfam05783 241 DEHFDFIQSHLRKFCLQYGAALIYTSVKETKNIDLLYKYIVHRSYGFPFTTPALVVEKDAVFIPAGWDNEKKIDILHENF 320 (475) T ss_pred HHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEHHEEEECCCCCCHHHHHHHHCCC T ss_conf 36799999999999987097589854776423899999999886076545622001000034058888145567543365 Q ss_pred CCCCCCCCCHHCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCC-CCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 435777664000578876532301334334268899999999861688887-6666766677888887555555666555 Q Ver_Hs_NP_0061 328 TTVKPEDAYEDFIVKPPVRKLVHDKELAAEDEQVFLMKQQSLLAKQPATPT-RASESPARGPSGSPRTQGRGGPASVPSS 406 (492) Q Consensus 328 ~~~~~~~~ye~iI~kPp~rk~~~~~ei~aEDeQ~FL~k~q~~l~~~p~~~~-r~~~sp~r~~~~~~~~~~~~~~~~~~~~ 406 (492) ++++++++||++|+|||+||++|++||+|||||+||+|||++|+++|++++ |+.+++ |+|+||+.+|+ +.++++. T Consensus 321 ~~~k~~~~~ed~i~kp~~rk~~~~~ei~aeddQ~Fl~k~q~~l~~~~~~~~~~~~~~~---~~~~p~~~~~~-~~~~~~~ 396 (475) T pfam05783 321 PTVKAEDAYEDIITKPPVRKVVHEKEIEAEDDQAFLMKLQSILAKQPTTAAPRPLRSQ---GVGSPRTMPRT-PGTVGQS 396 (475) T ss_pred CCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCC---CCCCCCCCCCC-CCCCCCC T ss_conf 4357876422344788402333333200012789999999997167877777755677---78887457745-5423666 Q ss_pred CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCC Q ss_conf 77866677778877765321036777888863277888887566666676465641025679999999863010135787 Q Ver_Hs_NP_0061 407 SPGTSVKKPDPNIKNNAASEGVLASFFNSLLSKKTGSPGSPGAGGVQSTAKKSGQKTVLSNVQEELDRMTRKPDSMVTNS 486 (492) Q Consensus 407 sp~~~~~k~dp~~~~~~~~EgvLanFFnsLL~Kk~~s~~~p~~~~~~~~~~~~~~~~~~~d~~~eldr~~~~~~~~~~~~ 486 (492) +| +||+||++++++++|||||||||||||||+||||+|++| +++|+++||+++++|||||||||+|+|+++.+++ T Consensus 397 ~p---~kk~dp~~~~~~~~egvlanffnsll~kk~~sp~~~~~~--~~~~~~~~~~~~~~d~~~eldr~~r~~~~~~~~~ 471 (475) T pfam05783 397 SP---TKKIDPNLKATAGSEGVLANFFNSLLSKKTGSPGKPGPG--GSSPSTVGQKMVLSDVQAELDRLTRSPQSPKPMS 471 (475) T ss_pred CC---CCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCC--CCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCC T ss_conf 77---646677757886431157777776630357888888888--8776466531237899999998743778777888 Q ss_pred CCCC Q ss_conf 5456 Q Ver_Hs_NP_0061 487 STEN 490 (492) Q Consensus 487 ~~~~ 490 (492) +||+ T Consensus 472 ~~~~ 475 (475) T pfam05783 472 PTES 475 (475) T ss_pred CCCC T ss_conf 6789 No 2 >PF05783 DLIC: Dynein light intermediate chain (DLIC); InterPro: IPR008467 This family consists of several eukaryotic dynein light intermediate chain proteins. The light intermediate chains (LICs) of cytoplasmic dynein consist of multiple isoforms, which undergo post-translational modification to produce a large number of species. DLIC1 is known to be involved in assembly, organisation, and function of centrosomes and mitotic spindles when bound to pericentrin. DLIC2 is a subunit of cytoplasmic dynein 2 that may play a role in maintaining Golgi organisation by binding cytoplasmic dynein 2 to its Golgi-associated cargo .; GO: 0003774 motor activity Probab=100.00 E-value=0 Score=1306.99 Aligned_columns=482 Identities=73% Q ss_pred EEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCCCC-E Q ss_conf 023458876423565445674344068999999998178622788764888607885489999986201336787431-0 Q Ver_Hs_NP_0061 9 KLLLGPNGPAVAAAGDLTSEEEEGQSLWSSILSEVSTRARSKLPSGKNILVFGEDGSGKTTLMTKLQGAEHGKKGRGL-E 87 (492) Q Consensus 9 ~~~~~~~~~~~~~~~~~~~~~~~~~~lWssil~eV~~~~~~klp~~KnILvLG~~~sGKttLi~~Lq~~e~~kkg~gL-e 87 (492) +...++|+++..+.++...+++|++|||++||+||++++++|||+||||||||+++|||||||++|||+|+.+||+|| | T Consensus 2 ~~~~~~n~~~~~~~~~~~~~~~e~~~lWs~iL~evst~~~sklp~gk~vlVLGd~~sGKttLlakLqg~e~~~Kg~gLle 81 (525) T PF05783_consen 2 ESDTTANAVTSSATAALKSEEEEKENLWSSILSEVSTRSNSKLPSGKNVLVLGDNGSGKTTLLAKLQGVEETKKGRGLLE 81 (525) T ss_pred CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCCCCCCCCC T ss_conf 77754554444343444530235433889998875412451057886168861788767899998723443446764111 Q ss_pred EEEEECCCCCCC-----------------CCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEEEEHHHHCCHHHHHHHHH Q ss_conf 335302121347-----------------300100588567602113532247734330210200021203247999999 Q Ver_Hs_NP_0061 88 YLYLSVHDEDRD-----------------DHTRCNVWILDGDLYHKGLLKFAVSAESLPETLVIFVADMSRPWTVMESLQ 150 (492) Q Consensus 88 Y~Yl~V~D~drD-----------------d~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlVvI~lD~s~PW~~m~qL~ 150 (492) |+|+||||+||| |++||+||||||++||++||||||+++||+||||||++||++||+||++|+ T Consensus 82 Y~yl~v~dd~RD~~~~~~~~~~~~~~~p~d~tR~nVWiLdGd~~h~~LLKfAl~~~s~~~tlvilt~dms~PW~~mesLq 161 (525) T PF05783_consen 82 YLYLNVHDDDRDASYAYQLGTAGANLNPSDLTRLNVWILDGDAYHKGLLKFALNAESIADTLVILTLDMSRPWNLMESLQ 161 (525) T ss_pred EEEEEEEHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCHHHHHHHHH T ss_conf 34653110101212100000000112333101155157617525555544436854403458888753101035899999 Q ss_pred HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCCCCCCCEECCCCCEEEEE Q ss_conf 99999999997248888999999999999986203500057777676645456654000036888762214799407998 Q Ver_Hs_NP_0061 151 KWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLGDNVLTHNLGIPVLVV 230 (492) Q Consensus 151 ~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lPLgeg~Lt~NLGiPi~VV 230 (492) +|+.||++||++|++++|+++||+++++++||+|+||+++.+|+|+|++++.++.+|+++.||||+|+||+||||||||| T Consensus 162 kW~~Vl~ehi~kLki~~E~~~~meqrl~k~~QeY~EP~~~~~~sPqrr~~~~~s~~de~v~LPL~~g~Lt~NLGipi~VV 241 (525) T PF05783_consen 162 KWASVLREHIDKLKIPPEELKEMEQRLVKKFQEYVEPGEDLDGSPQRRTTVVSSSDDESVLLPLGEGTLTENLGIPIIVV 241 (525) T ss_pred HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEE T ss_conf 99999999996057898999999999999876431613368888410567787544332326688664114789517998 Q ss_pred EECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCEEEE Q ss_conf 50752255554205774778999999999999870873788456663567999999988872777676550331121453 Q Ver_Hs_NP_0061 231 CTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTYGFHFTTPALVVEKDAVFI 310 (492) Q Consensus 231 ctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~Hrlygfpf~~ka~VvdkD~IfI 310 (492) |||||+|++|||||+|+||||||||||||+|||+|||+|||||+|+++||+|||+||+||+|||||+++|+|||||+||| T Consensus 242 ctk~D~i~~LeKe~d~kdE~fDfIqq~lR~fcL~yGAsLiYTSvKe~kN~dllykYi~HrlYgf~f~~~a~vvekdavfi 321 (525) T PF05783_consen 242 CTKSDAISVLEKEHDYKDEHFDFIQQHLRRFCLQYGASLIYTSVKEEKNIDLLYKYIVHRLYGFPFKTPAQVVEKDAVFI 321 (525) T ss_pred EECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCEEEECCCEEE T ss_conf 50775134444204752778999999999999760740467404552108999999988760775577430341000120 Q ss_pred CCCCCCHHHHHHHHHCCCCCCCCCCCHHCCCCCCCCHHHC--CCCCCCCCHHHHHHHHHHHHHHCCCCCC-CCCCCCCCC Q ss_conf 6888837889987605543577766400057887653230--1334334268899999999861688887-666676667 Q Ver_Hs_NP_0061 311 PAGWDNEKKIAILHENFTTVKPEDAYEDFIVKPPVRKLVH--DKELAAEDEQVFLMKQQSLLAKQPATPT-RASESPARG 387 (492) Q Consensus 311 PaGWDs~~KI~Il~Enf~~~~~~~~ye~iI~kPp~rk~~~--~~ei~aEDeQ~FL~k~q~~l~~~p~~~~-r~~~sp~r~ 387 (492) ||||||++||.||||||++++++++||+||+|||+||++| ++||+|||||+||+|||++|++||++++ |+.+++.|. T Consensus 322 PaGwDn~kKI~Il~En~~~~K~dd~~ed~i~kpp~rk~v~~re~ei~aEddQ~FL~k~qs~La~q~~t~~~~p~~s~~r~ 401 (525) T PF05783_consen 322 PAGWDNLKKISILHENFQTVKPDDPYEDIITKPPVRKLVHNREKEIQAEDDQVFLMKQQSLLAKQPPTAAGRPLDSSSRA 401 (525) T ss_pred CCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC T ss_conf 36765113334432033446665432332126863300112245541120689999999986147877777655556777 Q ss_pred CCCCCCCCCCCCCCCCCCCCC-CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHC-CCCCCCCCCCCCCCCCCCCC------ Q ss_conf 788888755555566655577-8666777788777653210367778888632-77888887566666676465------ Q Ver_Hs_NP_0061 388 PSGSPRTQGRGGPASVPSSSP-GTSVKKPDPNIKNNAASEGVLASFFNSLLSK-KTGSPGSPGAGGVQSTAKKS------ 459 (492) Q Consensus 388 ~~~~~~~~~~~~~~~~~~~sp-~~~~~k~dp~~~~~~~~EgvLanFFnsLL~K-k~~s~~~p~~~~~~~~~~~~------ 459 (492) ++|+||+++|++++++++.+| +++++|+|||+++++++||||||||||||+| |+||||+|+.||+...++++ T Consensus 402 ~~gsprt~~rs~~~~~~~~sP~~~~~kK~dPn~~~~~~~EgvLANFFnSLLsKdKtgsPg~~~~gg~~~~~~~S~~~g~~ 481 (525) T PF05783_consen 402 PSGSPRTPNRSGPSNVAQVSPIMAGTKKPDPNIKATASSEGVLANFFNSLLSKDKTGSPGSPGTGGAGSPAKKSGGGGGA 481 (525) T ss_pred CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC T ss_conf 88887778765666666556555556677865456753202678888876520246788887766532223455555566 Q ss_pred -------------CCCHHHHHHHHHHHHHHHHHCCCCCCCCCCC Q ss_conf -------------6410256799999998630101357875456 Q Ver_Hs_NP_0061 460 -------------GQKTVLSNVQEELDRMTRKPDSMVTNSSTEN 490 (492) Q Consensus 460 -------------~~~~~~~d~~~eldr~~~~~~~~~~~~~~~~ 490 (492) ||+++++|+|||||||+|+|++++++++|++ T Consensus 482 ~~~~~~~~s~~~~~q~~~~td~qaELDRl~r~~~~~~~~~~t~~ 525 (525) T PF05783_consen 482 GSGSSLASSAKTSGQKPVLTDVQAELDRLSRKPDSVVPTSPTES 525 (525) T ss_pred CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCC T ss_conf 66677765544555310278999999986315342357777899 No 3 >KOG3905 Dynein light intermediate chain [Cell motility] Probab=100.00 E-value=0 Score=1279.61 Aligned_columns=472 Identities=74% Q ss_pred CCCCCCEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCCC Q ss_conf 75535202345887642356544567434406899999999817862278876488860788548999998620133678 Q Ver_Hs_NP_0061 3 PVGVEKKLLLGPNGPAVAAAGDLTSEEEEGQSLWSSILSEVSTRARSKLPSGKNILVFGEDGSGKTTLMTKLQGAEHGKK 82 (492) Q Consensus 3 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~lWssil~eV~~~~~~klp~~KnILvLG~~~sGKttLi~~Lq~~e~~kk 82 (492) |+|+++.|.+||+|+|||..|..+.++++||||||+||+||+|++|+|||+||||||||++++|||+||.+|||+|+.|| T Consensus 1 ppg~~~~l~~g~~~nav~s~~~~~~deeegqnlWs~iLsev~T~~~sklpsgk~VlvlGdn~sGKtsLi~klqg~e~~Kk 80 (473) T KOG3905 1 PPGTAQPLEFGPTGNAVASVGYSSTDEEEGQNLWSEILSEVSTRTRSKLPSGKNVLVLGDNGSGKTSLISKLQGSETVKK 80 (473) T ss_pred CCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCCC T ss_conf 98866532468741345443201453567789999998654201234477886579970588745789887630245677 Q ss_pred CCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEEEEHHHHCCHHHHHHHHHHHHHHHHHHHHH Q ss_conf 74310335302121347300100588567602113532247734330210200021203247999999999999999972 Q Ver_Hs_NP_0061 83 GRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLVIFVADMSRPWTVMESLQKWASVLREHIDK 162 (492) Q Consensus 83 g~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlVvI~lD~s~PW~~m~qL~~Wi~vLr~hi~~ 162 (492) |+||||+||+|||+||||++||+||||||++||++||||||++.|+++||||+++||++||+||++|++|++|||+||++ T Consensus 81 gsgLeY~yl~V~de~RDd~tr~~VWiLDGd~~h~~LLk~al~ats~aetlviltasms~Pw~~lesLqkWa~Vl~ehidk 160 (473) T KOG3905 81 GSGLEYLYLHVHDEDRDDLTRCNVWILDGDLYHKGLLKFALPATSLAETLVILTASMSNPWTLLESLQKWASVLREHIDK 160 (473) T ss_pred CCCCEEEEEEECCCCHHHHHHCCCEEECCCHHHHHHHHHCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHH T ss_conf 65312678862131004465487148718755521243204655615458989986575035899999999999998986 Q ss_pred CCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCCCCCCCEECCCCCEEEEEEECCCHHHHHHH Q ss_conf 48888999999999999986203500057777676645456654000036888762214799407998507522555542 Q Ver_Hs_NP_0061 163 MKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLGDNVLTHNLGIPVLVVCTKCDAVSVLEK 242 (492) Q Consensus 163 L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lPLgeg~Lt~NLGiPi~VVctKsD~ie~LeK 242 (492) +++++|+|++++++++++||+|+||+++++|+|+||+++.++..|+++.|||++++||+|||||++|||||||+|.+||| T Consensus 161 l~i~~ee~ka~rqk~~k~wQeYvep~e~~pgsp~~r~t~~~~~~de~~llPL~~dtLt~NlGi~vlVV~TK~D~~s~lek 240 (473) T KOG3905 161 LKIPPEEMKAGRQKLEKDWQEYVEPGEDQPGSPQRRTTVVGSSADEHVLLPLGQDTLTHNLGIPVLVVCTKCDAVSVLEK 240 (473) T ss_pred HCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCEEEEEECCCHHHHHHH T ss_conf 25898999999999888889760512478888620343335655311112267762000068747999842430334552 Q ss_pred CCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCEEEECCCCCCHHHHHH Q ss_conf 05774778999999999999870873788456663567999999988872777676550331121453688883788998 Q Ver_Hs_NP_0061 243 EHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTYGFHFTTPALVVEKDAVFIPAGWDNEKKIAI 322 (492) Q Consensus 243 e~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~Hrlygfpf~~ka~VvdkD~IfIPaGWDs~~KI~I 322 (492) ||+|+||||||||+|||+|||+|||+|||||+||.||||||||||+||+|||||+++|+|||||+|||||||||+|||.| T Consensus 241 e~eyrDehfdfiq~~lRkFCLr~GaaLiyTSvKE~KNidllyKYivhr~yG~~fttpAlVVEkdaVfIPAGWD~eKKI~I 320 (473) T KOG3905 241 EHEYRDEHFDFIQSHLRKFCLRYGAALIYTSVKETKNIDLLYKYIVHRSYGFPFTTPALVVEKDAVFIPAGWDNEKKIDI 320 (473) T ss_pred CCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCHHHEEECCEEEECCCCCCCCHHHH T ss_conf 01001678999999999999860630255411124556888888887641553135001232031463046686300221 Q ss_pred HHHCCCCCCCCCCCHHCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCC-CCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 76055435777664000578876532301334334268899999999861688887-66667666778888875555556 Q Ver_Hs_NP_0061 323 LHENFTTVKPEDAYEDFIVKPPVRKLVHDKELAAEDEQVFLMKQQSLLAKQPATPT-RASESPARGPSGSPRTQGRGGPA 401 (492) Q Consensus 323 l~Enf~~~~~~~~ye~iI~kPp~rk~~~~~ei~aEDeQ~FL~k~q~~l~~~p~~~~-r~~~sp~r~~~~~~~~~~~~~~~ 401 (492) |||||+.++++++|++||.+||+||.+|++||+|||||+||||||++|+++|++++ |+.+++.|.|+++||++||++++ T Consensus 321 l~En~~~vkaed~y~d~itkpp~Rk~v~ekei~aEddQaFL~k~q~iLak~~~t~a~rp~~sq~~~~~ksprtpg~~g~s 400 (473) T KOG3905 321 LHENFPTVKAEDNYEDIITKPPVRKVVHEKEIEAEDDQAFLMKLQSILAKQPTTAAPRPRTSQERGPDKSPRTPGRSGSS 400 (473) T ss_pred HHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC T ss_conf 00035677877653324368840156666654101378999999998605888888786546788878887678887666 Q ss_pred CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC Q ss_conf 66555778666777788777653210367778888632778888875666666764656410256799999998630101 Q Ver_Hs_NP_0061 402 SVPSSSPGTSVKKPDPNIKNNAASEGVLASFFNSLLSKKTGSPGSPGAGGVQSTAKKSGQKTVLSNVQEELDRMTRKPDS 481 (492) Q Consensus 402 ~~~~~sp~~~~~k~dp~~~~~~~~EgvLanFFnsLL~Kk~~s~~~p~~~~~~~~~~~~~~~~~~~d~~~eldr~~~~~~~ 481 (492) ||. +|.+| ++|||||||||||||||+||||+||+|+.+++++|+||+++++ |+||||||+|+|+ T Consensus 401 -----SP~---k~~~P------~segVlasffnsll~kktgspg~~g~g~~~s~~~k~~q~~v~~-v~aeldr~trk~~- 464 (473) T KOG3905 401 -----SPL---KKSDP------TSEGVLASFFNSLLSKKTGSPGGPGAGGGSSSTKKSGQKPVLD-VHAELDRITRKPV- 464 (473) T ss_pred -----CCC---CCCCC------HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHH-HHHHHHHHHCCCC- T ss_conf -----788---88885------0246789999988641268888888876542113531025788-9999887513777- Q ss_pred CCCCCCCCCCC Q ss_conf 35787545689 Q Ver_Hs_NP_0061 482 MVTNSSTENEA 492 (492) Q Consensus 482 ~~~~~~~~~~~ 492 (492) ++++||+|| T Consensus 465 --t~~~te~e~ 473 (473) T KOG3905 465 --TPTSTEGEA 473 (473) T ss_pred --CCCCCCCCC T ss_conf --777655689 No 4 >PTHR12688 DYNEIN LIGHT INTERMEDIATE CHAIN; InterPro: IPR008467 This family consists of several eukaryotic dynein light intermediate chain proteins. The light intermediate chains (LICs) of cytoplasmic dynein consist of multiple isoforms, which undergo post-translational modification to produce a large number of species. DLIC1 is known to be involved in assembly, organisation, and function of centrosomes and mitotic spindles when bound to pericentrin. DLIC2 is a subunit of cytoplasmic dynein 2 that may play a role in maintaining Golgi organisation by binding cytoplasmic dynein 2 to its Golgi-associated cargo .; GO: 0003774 motor activity. Probab=100.00 E-value=0 Score=982.38 Aligned_columns=401 Identities=87% Q ss_pred CCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHCC Q ss_conf 31033530212134730010058856760211353224773433021020002120324799999999999999997248 Q Ver_Hs_NP_0061 85 GLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLVIFVADMSRPWTVMESLQKWASVLREHIDKMK 164 (492) Q Consensus 85 gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlVvI~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~ 164 (492) ||+|+|++|||+||||++||+||||||++||++||||+++++|+|+|||+|++||++||+||++||+|++|||+|+++|+ T Consensus 1 g~~Y~y~~v~d~d~d~~~r~~vW~Ldgd~~~~gLlk~a~~~~s~~~tl~~~~~dm~~PW~~~~~L~~W~~v~~~~~~kl~ 80 (415) T PTHR12688 1 GLEYLYLNVHDEDRDDLTRCNVWILDGDLYHKGLLKFALSAESLPDTLVILVADMSKPWTVMDSLQKWASVLREHIDKLK 80 (415) T ss_pred CCCHHHHHHHHCCHHHHHHCCCEEECCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHC T ss_conf 92013220110360134321010343527677788863173017899999999872255799999999999999998733 Q ss_pred CCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCCCCCCCEECCCCCEEEEEEECCCHHHHHHHCC Q ss_conf 88899999999999998620350005777767664545665400003688876221479940799850752255554205 Q Ver_Hs_NP_0061 165 IPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLGDNVLTHNLGIPVLVVCTKCDAVSVLEKEH 244 (492) Q Consensus 165 i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lPLgeg~Lt~NLGiPi~VVctKsD~ie~LeKe~ 244 (492) +++|+|+|+++++.+.||+|+||.++..+++.++.. ++.+.+|+++++||+|||+|++|||||||.|++||||| T Consensus 81 i~~~~~~~~~~~~~~~~q~y~e~~~~~~~s~~~~~~------d~~~~lp~~~~~lt~nlG~~~~vV~~k~d~~~~L~ke~ 154 (415) T PTHR12688 81 IPPEEMKELEQKLVKDFQEYVEPGEGLPGSPLRRNA------DELVPLPLGEGTLTHNLGIPVVVVCTKSDAMSVLEKEH 154 (415) T ss_pred CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHH------HHHHHCCCCHHHHHHHCCCEEEEEEECCHHHHHHHHHC T ss_conf 888899999999999754210200133334201123------44431234124677637916999874131578875430 Q ss_pred CCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCEEEECCCCCCHHHHHHHH Q ss_conf 77477899999999999987087378845666356799999998887277767655033112145368888378899876 Q Ver_Hs_NP_0061 245 DYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTYGFHFTTPALVVEKDAVFIPAGWDNEKKIAILH 324 (492) Q Consensus 245 ~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~Hrlygfpf~~ka~VvdkD~IfIPaGWDs~~KI~Il~ 324 (492) +|+||||||||++||+|||+|||||||||+||+|||+||||||+||+|||||+.+|.|||||+||||||||++|||+||| T Consensus 155 dyrdehfDfiq~~lR~fcL~yga~L~ytsvke~kN~dLlykYivh~~yGf~f~~~a~VvekdavfiPaGWD~~kKI~il~ 234 (415) T PTHR12688 155 DYRDEHFDFIQSHLRKFCLQYGAALIYTSVKEEKNIDLLYKYIVHKLYGFPFTIPALVVEKDAVFIPAGWDNEKKIGILH 234 (415) T ss_pred CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHEEEEEEEEECCCCCCHHHHHHHH T ss_conf 31288999999999999998402531101001334899999998886065434401112200045168988077889876 Q ss_pred HCCCCCCCCCCCHHCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 05543577766400057887653230133433426889999999986168888766667666778888875555556665 Q Ver_Hs_NP_0061 325 ENFTTVKPEDAYEDFIVKPPVRKLVHDKELAAEDEQVFLMKQQSLLAKQPATPTRASESPARGPSGSPRTQGRGGPASVP 404 (492) Q Consensus 325 Enf~~~~~~~~ye~iI~kPp~rk~~~~~ei~aEDeQ~FL~k~q~~l~~~p~~~~r~~~sp~r~~~~~~~~~~~~~~~~~~ 404 (492) |||++++++++|+++|+|||+||.+|++|+.|||||+||+|||++|++||+++++..++|.|.|+||||+++|+++.+++ T Consensus 235 enf~~~~~~d~y~d~i~~P~~Rk~v~~~~~~aed~Q~fl~k~~~~l~~~~~~~~~~~e~p~r~~~~S~~~~~~~~~~~~~ 314 (415) T PTHR12688 235 ENFTTVKPEDAYEDIIVKPPVRKLVHEKEIAAEDEQVFLMKQQSLLAKQPATPTRTSESPARGPGGSPRTQGRGGPASVP 314 (415) T ss_pred CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC T ss_conf 05200244421011025785012345888754467789999999985212321100001112566654456777654221 Q ss_pred CCCCCC-CCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCC Q ss_conf 557786-6677778877765321036777888863277888887566666676465641025679999999863010135 Q Ver_Hs_NP_0061 405 SSSPGT-SVKKPDPNIKNNAASEGVLASFFNSLLSKKTGSPGSPGAGGVQSTAKKSGQKTVLSNVQEELDRMTRKPDSMV 483 (492) Q Consensus 405 ~~sp~~-~~~k~dp~~~~~~~~EgvLanFFnsLL~Kk~~s~~~p~~~~~~~~~~~~~~~~~~~d~~~eldr~~~~~~~~~ 483 (492) +++|++ +++|+||+.++++.+||||||||||||+||+||+|+|+.||..++++++||+...+++|+||||+.|+|++.. T Consensus 315 ~~~~~~~~~~k~d~~~~~~~~~~g~la~ffn~Ll~k~~gs~g~~~~gg~~~~~~~~g~~~~~~~~~~~l~~~~~~~~~~~ 394 (415) T PTHR12688 315 SASPGTASVKKPDPNLKNNAASEGVLANFFNSLLSKKTGSPGSPGAGGVQSTAKKSGQKGVLSDVQAELDRLLRKPDSVV 394 (415) T ss_pred CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC T ss_conf 10234555554452100343011256777765531035788876545555554333431467778999999863011103 Q ss_pred CCCCCCCC Q ss_conf 78754568 Q Ver_Hs_NP_0061 484 TNSSTENE 491 (492) Q Consensus 484 ~~~~~~~~ 491 (492) ++++++++ T Consensus 395 ~~~~~~~~ 402 (415) T PTHR12688 395 PTSPTENE 402 (415) T ss_pred CCCCCHHH T ss_conf 67630256 No 5 >PTHR13236 DYNEIN 2 LIGHT INTERMEDIATE CHAIN, ISOFORM 2. Probab=99.92 E-value=8.7e-25 Score=188.68 Aligned_columns=281 Identities=23% Q ss_pred HHHHHHHHHHHHHC------CCCCCCCCCEEEEEECCCCCHHHHHHH-HHCCCCCCCCCCCEEEEEECCCCCCCCCCCCC Q ss_conf 06899999999817------862278876488860788548999998-62013367874310335302121347300100 Q Ver_Hs_NP_0061 33 QSLWSSILSEVSTR------ARSKLPSGKNILVFGEDGSGKTTLMTK-LQGAEHGKKGRGLEYLYLSVHDEDRDDHTRCN 105 (492) Q Consensus 33 ~~lWssil~eV~~~------~~~klp~~KnILvLG~~~sGKttLi~~-Lq~~e~~kkg~gLeY~Yl~V~D~drDd~~R~~ 105 (492) ++||...-.+|..+ +..-.+..|.|.++|.++.||||+|.+ |..-|.++...+|||+|.....-....+.-+| T Consensus 13 e~lw~~A~~~~e~rg~~g~~gdg~e~~e~~~ffiGsk~gGKttiilr~ldrde~~kPtlaLEYtygRr~~g~~~~Kdiah 92 (397) T PTHR13236 13 ETLWEIAKAEVEKRGINGSEGDGAEIAEKFVFFIGSKNGGKTTIILRCLDRDEPPKPTLALEYTYGRRAKGHNTPKDIAH 92 (397) T ss_pred HHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEEECCCCHHHHHHHHHCCCCCCCCCEEEEECHHHHHCCCCCCCCEEE T ss_conf 65899999999851567541135300101688887348854667765632345678740000001111046888530356 Q ss_pred EEEECCCCCCCCCCCCCCCCCCHHHEEEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHC-----CCCHHHHHHHHHHHHHH Q ss_conf 5885676021135322477343302102000212032479999999999999999724-----88889999999999999 Q Ver_Hs_NP_0061 106 VWILDGDLYHKGLLKFAVSAESLPETLVIFVADMSRPWTVMESLQKWASVLREHIDKM-----KIPPEKMRELERKFVKD 180 (492) Q Consensus 106 VwiLdg~~~~~~LLk~al~~~si~~TlVvI~lD~s~PW~~m~qL~~Wi~vLr~hi~~L-----~i~~e~~~e~~~~~~~~ 180 (492) +|.|.|......||-..++.+++....+|++||+|+|..+...+..|+.-++.++++. +...+...|++++.+.. T Consensus 93 ~WELGGg~~~~~li~iPit~~~l~~~~~~lvLDlS~p~~~w~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~r~~~~~~ 172 (397) T PTHR13236 93 FWELGGGTSLLDLISIPITGDTLRTFSLVLVLDLSKPNDLWPTLENLLQATKSHVDKVLLKLGKTNAKAVSEMRQRIWNN 172 (397) T ss_pred EEECCCCCCHHHHHHHCCCCHHHHHEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_conf 55317742457786412230125312011044057640024549999999999999999985201356789888888742 Q ss_pred HHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCCCCCCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHH Q ss_conf 86203500057777676645456654000036888762214799407998507522555542057747789999999999 Q Ver_Hs_NP_0061 181 FQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLGDNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRR 260 (492) Q Consensus 181 ~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lPLgeg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~ 260 (492) + ..+..-.+-.....+........+.....-..+-.....++||+++|..|.|.+ .++..|...++-+.||. T Consensus 173 ~--~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~p~~~~i~g~kyD~f------~~~~~e~rk~~~~~Lr~ 244 (397) T PTHR13236 173 M--PKDHPVSCCLGLLLESLVPFIVNDNITGNAFPDLELVDPFPIPLVIVGSKYDVF------QDFDSEKRKVICRTLRF 244 (397) T ss_pred H--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHH------CCCCHHHHHHHHHHHHH T ss_conf 0--012468999999998888888887776432023565510781168852011011------05446789999999999 Q ss_pred HHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCEEEECCCCCCHHHHH Q ss_conf 9987087378845666356799999998887277767655033112145368888378899 Q Ver_Hs_NP_0061 261 FCLQYGAALIYTSVKEEKNLDLLYKYIVHKTYGFHFTTPALVVEKDAVFIPAGWDNEKKIA 321 (492) Q Consensus 261 ~cL~YGAsLiYTS~ke~kNl~lLykYi~Hrlygfpf~~ka~VvdkD~IfIPaGWDs~~KI~ 321 (492) ++..|||+|+|.|.+...-...++..+.|-.||.+......+.....++||+|.|+|.+|. T Consensus 245 ~ah~~Ga~L~~~s~~~~~l~~~~~~~~~~l~Fg~~~~~~~~~~~~~P~~~~~g~d~~~~~g 305 (397) T PTHR13236 245 LAHAYGASLLFLSSKSEALLKKVRGVINHLAFGSPLPKSILVDHNKPLAIPAGLDSLAKIG 305 (397) T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHCC T ss_conf 9997436876774225899999999998886303566776520457716870613476606 No 6 >KOG3929 Uncharacterized conserved protein [Function unknown] Probab=99.87 E-value=1.2e-21 Score=167.67 Aligned_columns=246 Identities=30% Q ss_pred CCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCHHHHHHH-HHCCCCCCCC-CCCEEEEEECCCCCCCCC Q ss_conf 44567434406899999999817862278876488860788548999998-6201336787-431033530212134730 Q Ver_Hs_NP_0061 24 DLTSEEEEGQSLWSSILSEVSTRARSKLPSGKNILVFGEDGSGKTTLMTK-LQGAEHGKKG-RGLEYLYLSVHDEDRDDH 101 (492) Q Consensus 24 ~~~~~~~~~~~lWssil~eV~~~~~~klp~~KnILvLG~~~sGKttLi~~-Lq~~e~~kkg-~gLeY~Yl~V~D~drDd~ 101 (492) |++.-+-|-| |+||.++.- ..|+++|+++. +++|.+ ..+-|.+..+ ++|||+|-..-.-. +.. T Consensus 27 DinG~~~deq------L~e~~~~~E------~~I~~~Gn~~~--tt~I~~~FdR~e~~~~ptlaLEYtygRR~~g~-~~k 91 (363) T KOG3929 27 DINGSEGDEQ------LAEIAEKFE------FFIGSKGNGGK--TTIILRCFDRDEPPKPPTLALEYTYGRRAKGH-NPK 91 (363) T ss_pred HHCCCHHHHH------HHHHHCCHH------CEEEEECCCCE--EEEEEECCCCCCCCCCCCEEEEEHHHHHHCCC-CCH T ss_conf 3123213789------998503002------05677338850--66533005765678997212210123441478-851 Q ss_pred CCCCEEEECCCCCCCCCCCCCCCCCCHHHEEEEEHHHHCCH---HHHHHHHHHHHHHHHHHHHHC-----CCCHHHHHHH Q ss_conf 01005885676021135322477343302102000212032---479999999999999999724-----8888999999 Q Ver_Hs_NP_0061 102 TRCNVWILDGDLYHKGLLKFAVSAESLPETLVIFVADMSRP---WTVMESLQKWASVLREHIDKM-----KIPPEKMREL 173 (492) Q Consensus 102 ~R~~VwiLdg~~~~~~LLk~al~~~si~~TlVvI~lD~s~P---W~~m~qL~~Wi~vLr~hi~~L-----~i~~e~~~e~ 173 (492) ...|||.|.|......||-..++-+++.-+.+|++||||+| |+-|+.+-+ -+|.|++++ ++.++...+| T Consensus 92 diaN~WELGgg~~~~~LLsVPit~~~l~~~slIL~LDls~p~~~W~t~E~~~~---~~R~~vd~~~~~~~k~~~~L~E~m 168 (363) T KOG3929 92 DIANFWELGGGTSLLDLLSVPITGDTLRTFSLILVLDLSKPNDLWPTMENLLQ---ATRSHVDKVIMKLGKTNAKLVEEM 168 (363) T ss_pred HHHHHHHCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHH---HHHHHHHHHHHHHHCCCHHHHHHH T ss_conf 45655532673246888605545562877566676511562443257999999---999899999998741488999999 Q ss_pred HHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCCCCCCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHH Q ss_conf 99999998620350005777767664545665400003688876221479940799850752255554205774778999 Q Ver_Hs_NP_0061 174 ERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLGDNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDF 253 (492) Q Consensus 174 ~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lPLgeg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~ 253 (492) ++++|+. |----++-++-+.+.||+++|..|.|-+ ++|..|...- T Consensus 169 rqR~~~r-----------------------------vgqd~~d~e~~dP~P~PV~IVgsKYDvF------q~FesekRkH 213 (363) T KOG3929 169 RQRIWNR-----------------------------VGQDHPDHELIDPFPVPVVIVGSKYDVF------QDFESEKRKH 213 (363) T ss_pred HHHHHHH-----------------------------HCCCCCCCCCCCCCCCCEEEECCCCHHH------CCCCHHHHHH T ss_conf 9999986-----------------------------2146874000277885347853520001------2663678999 Q ss_pred HHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCEEEECCCCCCHHHHHH Q ss_conf 999999999870873788456663567999999988872777676550331121453688883788998 Q Ver_Hs_NP_0061 254 IQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTYGFHFTTPALVVEKDAVFIPAGWDNEKKIAI 322 (492) Q Consensus 254 Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~Hrlygfpf~~ka~VvdkD~IfIPaGWDs~~KI~I 322 (492) +-++||.++..|||+|.+-|.|-++-..+++--+-|--||.+-.....|+.-..+||-+|.|||++|++ T Consensus 214 ~C~~LRf~Ah~yGaaLlmfSskMe~l~K~ir~~i~HlaFG~~~~~s~~vD~NkPlfi~~G~DS~~~IG~ 282 (363) T KOG3929 214 ICKTLRFVAHYYGAALLMFSSKMEALLKKIRGVINHLAFGIDKSKSICVDQNKPLFITAGLDSFGQIGS 282 (363) T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCEEEEECCCCHHHCCC T ss_conf 999999999997789999888789999998777775404765766545307874589855532233378 No 7 >2q3h_A RAS homolog gene family, member U; GTPase, structural genomics, structural genomics consortium, SGC; HET: GDP; 1.73A {Homo sapiens} Probab=99.17 E-value=8.8e-10 Score=88.13 Aligned_columns=185 Identities=18% Q ss_pred HHHHCCCCCCCCCCEE--EEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCC Q ss_conf 9981786227887648--88607885489999986201336787431033530212134730010058856760211353 Q Ver_Hs_NP_0061 42 EVSTRARSKLPSGKNI--LVFGEDGSGKTTLMTKLQGAEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLL 119 (492) Q Consensus 42 eV~~~~~~klp~~KnI--LvLG~~~sGKttLi~~Lq~~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LL 119 (492) |-..+++.--|++|+| +|+|+.++|||||+.+|.+.+...........+..+.-......-++.+|-..|...+..+. T Consensus 6 ~~~~~~~~~~~~~k~iKV~iiG~~gvGKTsLi~~l~~~~~~~~~~~t~~~~~~~~~~~~~~~~~l~i~D~~g~~~~~~~~ 85 (201) T 2q3h_A 6 EPGGRGRAGGAEGRGVKCVLVGDGAVGKTSLVVSYTTNGYPTEYIPTAFDNFSAVVSVDGRPVRLQLCDTAGQDEFDKLR 85 (201) T ss_dssp --------------CEEEEEECSTTSSHHHHHHHHHC--------CCSSEEEEEEEEETTEEEEEEEEECCCSTTCSSSG T ss_pred CCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEECCEEEEEEECCCCCCHHHCCCC T ss_conf 87777788888887248998707997789999998717656553422555789999860605665303465200110012 Q ss_pred CCCCCCCCHHHEEEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCC Q ss_conf 22477343302102000212032479999999999999999724888899999999999998620350005777767664 Q Ver_Hs_NP_0061 120 KFAVSAESLPETLVIFVADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRG 199 (492) Q Consensus 120 k~al~~~si~~TlVvI~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~ 199 (492) +..+..- ..++||.|++.+.++.+.++.|+..++.+.. T Consensus 86 ~~~~~~a----~~~iiV~d~~~~~Sf~~~~~~~~~~i~~~~~-------------------------------------- 123 (201) T 2q3h_A 86 PLCYTNT----DIFLLCFSVVSPSSFQNVSEKWVPEIRCHCP-------------------------------------- 123 (201) T ss_dssp GGGGTTC----SEEEEEEETTCHHHHHHHHHTHHHHHHHHCS-------------------------------------- T ss_pred CCHHHHH----HHCCEEEECCCHHHHHHHHHHHHHHHHHHCC-------------------------------------- T ss_conf 0010012----2122112113166677899987655543067-------------------------------------- Q ss_pred CCCCCCCCHHCCCCCCCCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHH-HHHHHHHHHHHHCCCEEEE-ECCCCC Q ss_conf 54566540000368887622147994079985075225555420577477899-9999999999870873788-456663 Q Ver_Hs_NP_0061 200 PLTSGSDEENVALPLGDNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLD-FIQSHLRRFCLQYGAALIY-TSVKEE 277 (492) Q Consensus 200 ~~~s~~de~~v~lPLgeg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD-~Iqq~LR~~cL~YGAsLiY-TS~ke~ 277 (492) .+|+++|++|+|..+.............. +..+..+.+|-++++-.+| ||++.. T Consensus 124 ------------------------~~piiivgnK~D~~~~~~~~~~~~~~~~~~i~~~~~~~~~~~~~~~~~~e~Sak~~ 179 (201) T 2q3h_A 124 ------------------------KAPIILVGTQSDLREDVKVLIELDKCKEKPVPEEAAKLLAEEIKAASYIECSALTQ 179 (201) T ss_dssp ------------------------SSCEEEEEECGGGGGCHHHHHHHHTTTCCCCCHHHHHHHHHHHTCSEEEECCTTTC T ss_pred ------------------------CCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEEECCCC T ss_conf ------------------------73688861147841135677776553125577899999999708953899851588 Q ss_pred CCHHHHHHHHHHHHH Q ss_conf 567999999988872 Q Ver_Hs_NP_0061 278 KNLDLLYKYIVHKTY 292 (492) Q Consensus 278 kNl~lLykYi~Hrly 292 (492) .|++-++.+++...+ T Consensus 180 ~gI~e~f~~ii~~al 194 (201) T 2q3h_A 180 KNLKEVFDAAIVAGI 194 (201) T ss_dssp TTHHHHHHHHHHHHH T ss_pred CCHHHHHHHHHHHHH T ss_conf 787899999999998 No 8 >cd04128 Spg1 Spg1p. Spg1p (septum-promoting GTPase) was first identified in the fission yeast S. pombe, where it regulates septum formation in the septation initiation network (SIN) through the cdc7 protein kinase. Spg1p is an essential gene that localizes to the spindle pole bodies. When GTP-bound, it binds cdc7 and causes it to translocate to spindle poles. Sid4p (septation initiation defective) is required for localization of Spg1p to the spindle pole body, and the ability of Spg1p to promote septum formation from any point in the cell cycle depends on Sid4p. Spg1p is negatively regulated by Byr4 and cdc16, which form a two-component GTPase activating protein (GAP) for Spg1p. The existence of a SIN-related pathway in plants has been proposed. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are Probab=99.10 E-value=1.8e-08 Score=79.28 Aligned_columns=177 Identities=25% Q ss_pred EEEEECCCCCHHHHHHHHHC---CCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEE Q ss_conf 88860788548999998620---133678743103353021213473001005885676021135322477343302102 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTKLQG---AEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLV 133 (492) Q Consensus 57 ILvLG~~~sGKttLi~~Lq~---~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlV 133 (492) |+++|+.++|||+|+.++-. .+.....-|++|.-..+.- .+..-.+.+|=..|.-.+.++.+....- --.+ T Consensus 3 ivliGd~~VGKTsLi~r~~~~~F~~~y~~TiG~~~~~k~i~v--~~~~v~l~iwDtaGqE~f~~~~~~y~~~----a~~~ 76 (182) T cd04128 3 IGLLGDAQIGKTSLMVKYVEGEFDEDYIQTLGVNFMEKTISI--RGTEITFSIWDLGGQREFINMLPLVCND----AVAI 76 (182) T ss_pred EEEEECCCCCHHHHHHHHHCCEECCCCCCEEEEEEEEEEEEE--CCEEEEEEEEECCCCCCCHHHHHHHCCC----CCEE T ss_conf 899816984388887776437127763550344678989998--8968998873168883101277864037----7768 Q ss_pred EEHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCC Q ss_conf 00021203247999999999999999972488889999999999999862035000577776766454566540000368 Q Ver_Hs_NP_0061 134 IFVADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALP 213 (492) Q Consensus 134 vI~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lP 213 (492) +||-|.+.+-++ +++++|++.++.+-.. T Consensus 77 ilVfDit~~~Sf-~~i~~W~~~i~~~~~~--------------------------------------------------- 104 (182) T cd04128 77 LFMFDLTRKSTL-NSIKEWYRQARGFNKT--------------------------------------------------- 104 (182) T ss_pred EEEEECCCHHHH-HHHHHHHHHHHHHCCC--------------------------------------------------- T ss_conf 999865997899-9999999999862799--------------------------------------------------- Q ss_pred CCCCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHC Q ss_conf 88762214799407998507522555542057747789999999999998708737884566635679999999888727 Q Ver_Hs_NP_0061 214 LGDNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTYG 293 (492) Q Consensus 214 Lgeg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~Hrlyg 293 (492) .+|| +|.+|+|.+ .+...++-+.+....+.+|-++|+..|.||+|...|++-+.++++-++|+ T Consensus 105 ----------~~~I-LVGNK~DL~------~~~~~~~~~~~~~~~~~~a~~~~~~~~etSAktg~nV~e~Fe~l~~ki~~ 167 (182) T cd04128 105 ----------AIPI-LVGTKYDLF------ADLPPEEQEEITKQARKYAKAMKAPLIFCSTSHSINVQKIFKIVLAKAFD 167 (182) T ss_pred ----------CCEE-EEECCCCCC------CCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHC T ss_conf ----------6089-983274310------01442456778899999999729959999724798878999999999853 Q ss_pred CCCCCCCEEEECCEE Q ss_conf 776765503311214 Q Ver_Hs_NP_0061 294 FHFTTPALVVEKDAV 308 (492) Q Consensus 294 fpf~~ka~VvdkD~I 308 (492) ++.+.+.+.---+.| T Consensus 168 ~~~~~~~~~~~~~~~ 182 (182) T cd04128 168 LPLTIPEILTVGEPI 182 (182) T ss_pred CCCCCCCCCCCCCCC T ss_conf 788877668888899 No 9 >2hxs_A RAB-26, RAS-related protein RAB-28; GTPase, signaling protein; HET: G3D; 1.10A {Homo sapiens} Probab=99.04 E-value=4.7e-08 Score=76.56 Aligned_columns=167 Identities=25% Q ss_pred EEEEEECCCCCHHHHHHHHHC---CCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEE Q ss_conf 488860788548999998620---13367874310335302121347300100588567602113532247734330210 Q Ver_Hs_NP_0061 56 NILVFGEDGSGKTTLMTKLQG---AEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETL 132 (492) Q Consensus 56 nILvLG~~~sGKttLi~~Lq~---~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~Tl 132 (492) .|+|+|+.++|||||+.++.+ .++.....+.+|....|.-.+ ...-++.+|-..|...+..+.+..+.. -.. T Consensus 8 ki~iiG~~~vGKSsli~~~~~~~~~~~~~~T~~~~~~~~~v~~~~-~~~~~~~i~D~~g~~~~~~~~~~~~~~----~~~ 82 (178) T 2hxs_A 8 KIVVLGDGASGKTSLTTCFAQETFGKQYKQTIGLDFFLRRITLPG-NLNVTLQIWDIGGQTIGGKMLDKYIYG----AQG 82 (178) T ss_dssp EEEEECCTTSSHHHHHHHHHGGGTTHHHHHTTTSSEEEEEEEETT-TEEEEEEEEECTTCCTTCTTHHHHHTT----CSE T ss_pred EEEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEECCCC-CEEEEEEEEECCCCCCCCCCCCCCCCC----CCC T ss_conf 899980799889999999862833776222255423545322320-103567775314743122112111210----000 Q ss_pred EEEHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCC Q ss_conf 20002120324799999999999999997248888999999999999986203500057777676645456654000036 Q Ver_Hs_NP_0061 133 VIFVADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVAL 212 (492) Q Consensus 133 VvI~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~l 212 (492) +++|.|.+.|..+-. ++.|+..++.+.......+ T Consensus 83 ~i~v~d~~~~~s~~~-~~~~~~~i~~~~~~~~~~~--------------------------------------------- 116 (178) T 2hxs_A 83 VLLVYDITNYQSFEN-LEDWYTVVKKVSEESETQP--------------------------------------------- 116 (178) T ss_dssp EEEEEETTCHHHHHT-HHHHHHHHHHHHHHHTCCC--------------------------------------------- T ss_pred CEEEEECCCCCCCCC-HHHHHHHHHHHHCCCCCCC--------------------------------------------- T ss_conf 001322024554110-1245677753100246563--------------------------------------------- Q ss_pred CCCCCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHH Q ss_conf 88876221479940799850752255554205774778999999999999870873788456663567999999988872 Q Ver_Hs_NP_0061 213 PLGDNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTY 292 (492) Q Consensus 213 PLgeg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~Hrly 292 (492) |+++|++|+| |+.......|+. +.||-++++..+.||++...|++.+...|..+++ T Consensus 117 -------------~iilV~nK~D----l~~~~~v~~~~~-------~~~~~~~~~~~~~~Sa~~~~~I~e~f~~i~~~i~ 172 (178) T 2hxs_A 117 -------------LVALVGNKID----LEHMRTIKPEKH-------LRFCQENGFSSHFVSAKTGDSVFLCFQKVAAEIL 172 (178) T ss_dssp -------------EEEEEEECGG----GGGGCSSCHHHH-------HHHHHHHTCEEEEECTTTCTTHHHHHHHHHHHHT T ss_pred -------------EEEEEECCCC----CHHHHCCCHHHH-------HHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHH T ss_conf -------------0233302344----102220245889-------9999964990899961578788899999999998 Q ss_pred CCCCC Q ss_conf 77767 Q Ver_Hs_NP_0061 293 GFHFT 297 (492) Q Consensus 293 gfpf~ 297 (492) ++... T Consensus 173 ~~~~~ 177 (178) T 2hxs_A 173 GIKLN 177 (178) T ss_dssp TCCCC T ss_pred HHHCC T ss_conf 62126 No 10 >e1z2aa_ c.37.1.8 (A:) Rab23 {Mouse (Mus musculus) [TaxID:10090]} Probab=99.04 E-value=7.6e-09 Score=81.85 Aligned_columns=157 Identities=24% Q ss_pred EEEEEECCCCCHHHHHHHHHC---CCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEE Q ss_conf 488860788548999998620---13367874310335302121347300100588567602113532247734330210 Q Ver_Hs_NP_0061 56 NILVFGEDGSGKTTLMTKLQG---AEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETL 132 (492) Q Consensus 56 nILvLG~~~sGKttLi~~Lq~---~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~Tl 132 (492) .|+|+|..++|||||+.+|.+ .+.....-+.+|.+..+.-.+++ .++.+|-..|...+..+.+..+..-. . T Consensus 4 kI~ivG~~~vGKSsli~~l~~~~~~~~~~~t~~~~~~~~~~~~~~~~--~~l~i~d~~~~~~~~~~~~~~~~~~d----~ 77 (164) T e1z2aa_ 4 KMVVVGNGAVGKSSMIQRYCKGIFTKDYKKTIGVDFLERQIQVNDED--VRLMLWDTAGQEEFDAITKAYYRGAQ----A 77 (164) T ss_pred EEEEECCCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEEECCEE--EEEEECCCCCCCHHHHHHHHHCCCCC----E T ss_conf 89998289988999999986480167623404533588999973288--87410146422024577886405875----7 Q ss_pred EEEHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCC Q ss_conf 20002120324799999999999999997248888999999999999986203500057777676645456654000036 Q Ver_Hs_NP_0061 133 VIFVADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVAL 212 (492) Q Consensus 133 VvI~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~l 212 (492) +++|.|.+++.++ +.+..|+.-++.+..+ T Consensus 78 ~i~v~d~~~~~s~-~~~~~~~~~i~~~~~~-------------------------------------------------- 106 (164) T e1z2aa_ 78 CVLVFSTTDRESF-EAISSWREKVVAEVGD-------------------------------------------------- 106 (164) T ss_pred EEEEEECCCCCCH-HHHHHHHHHHHHHCCC-------------------------------------------------- T ss_conf 9999740455424-6788888874310023-------------------------------------------------- Q ss_pred CCCCCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHH Q ss_conf 88876221479940799850752255554205774778999999999999870873788456663567999999988872 Q Ver_Hs_NP_0061 213 PLGDNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTY 292 (492) Q Consensus 213 PLgeg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~Hrly 292 (492) +|++||++|+|. .++-.+-...++.|+-++++..+.||++...|++-++++|.-+.+ T Consensus 107 ------------~piiiv~nK~Dl-----------~~~~~i~~~~~~~~~~~~~~~~~e~Sa~~~~~i~~~f~~i~~k~l 163 (164) T e1z2aa_ 107 ------------IPTALVQNKIDL-----------LDDSCIKNEEAEGLAKRLKLRFYRTSVKEDLNVSEVFKYLAEKHL 163 (164) T ss_pred ------------CEEEEEEECCCC-----------CCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHC T ss_conf ------------002344420021-----------112367989999999965990999971589888899999999970 No 11 >d3raba_ c.37.1.8 (A:) Rab3a {Rat (Rattus norvegicus)} SCOP: d1zbda_ Probab=99.01 E-value=2.5e-08 Score=78.43 Aligned_columns=157 Identities=18% Q ss_pred EEEEECCCCCHHHHHHHHHC---CCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEE Q ss_conf 88860788548999998620---133678743103353021213473001005885676021135322477343302102 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTKLQG---AEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLV 133 (492) Q Consensus 57 ILvLG~~~sGKttLi~~Lq~---~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlV 133 (492) |+|+|+.++|||||+.+|.+ .+......+.++.+..+...++ ..++.+|-..|...+..+.+..+..-. .+ T Consensus 8 i~iiG~~~vGKTsLi~~~~~~~~~~~~~~~~~~~~~~~~i~~~~~--~~~~~i~d~~g~~~~~~~~~~~~~~~d----~~ 81 (169) T d3raba_ 8 ILIIGNSSVGKTSFLFRYADDSFTPAFVSTVGIDFKVKTIYRNDK--RIKLQIWDTAGQERYRTITTAYYRGAM----GF 81 (169) T ss_dssp EEEECSTTSSHHHHHHHHHHSCCCSSCCCCCSEEEEEEEEEETTE--EEEEEEEEECCSGGGHHHHHTTTTTCC----EE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEEECCE--EEEEEEEECCCCCHHHHHHHHHCCCCC----EE T ss_conf 999836998799999998658015440220110357899999886--899998515773112232121101345----78 Q ss_pred EEHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCC Q ss_conf 00021203247999999999999999972488889999999999999862035000577776766454566540000368 Q Ver_Hs_NP_0061 134 IFVADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALP 213 (492) Q Consensus 134 vI~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lP 213 (492) ++|.|.+.+.++ +.+.+|+..+++....- T Consensus 82 i~v~d~~~~~s~-~~~~~~~~~i~~~~~~~-------------------------------------------------- 110 (169) T d3raba_ 82 ILMYDITNEESF-NAVQDWSTQIKTYSWDN-------------------------------------------------- 110 (169) T ss_dssp EEEEETTCHHHH-HTHHHHHHHHHHHCCSC-------------------------------------------------- T ss_pred EEEEECCCCCHH-HHHHHHHHHHHHHHCCC-------------------------------------------------- T ss_conf 998622554205-66888999987653068-------------------------------------------------- Q ss_pred CCCCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHH Q ss_conf 8876221479940799850752255554205774778999999999999870873788456663567999999988872 Q Ver_Hs_NP_0061 214 LGDNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTY 292 (492) Q Consensus 214 Lgeg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~Hrly 292 (492) +|++||++|+|. .++..+..+-.+.++-++|...|.||++...|++-+.+.|++.+. T Consensus 111 -----------~pivvv~nK~Dl-----------~~~~~v~~~~~~~~~~~~~~~~~~~Sa~~g~~i~e~f~~li~~i~ 167 (169) T d3raba_ 111 -----------AQVLLVGNKCDM-----------EDERVVSSERGRQLADHLGFEFFEASAKDNINVKQTFERLVDVIC 167 (169) T ss_dssp -----------CEEEEEEECTTC-----------GGGCCSCHHHHHHHHHHHTCEEEECBTTTTBSHHHHHHHHHHHHH T ss_pred -----------CCEEHHHHCCCC-----------CCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHH T ss_conf -----------300000001232-----------111257888999999955983999872689888899999999996 No 12 >e2gjsa1 c.37.1.8 (A:91-258) Rad {Human (Homo sapiens) [TaxID:9606]} SCOP: u2gjsb_ Probab=99.01 E-value=2.3e-08 Score=78.59 Aligned_columns=159 Identities=21% Q ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEEEEH Q ss_conf 88860788548999998620133678743103353021213473001005885676021135322477343302102000 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTKLQGAEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLVIFV 136 (492) Q Consensus 57 ILvLG~~~sGKttLi~~Lq~~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlVvI~ 136 (492) |+|+|..++|||+|+.++.+.+........+-.|-..-.-+ +..-.+++|-..|...+..+.+..+..-.+ ++|| T Consensus 4 I~iiG~~~vGKTsli~~~~~~~~~~~~~~~~~~~~~~i~i~-~~~~~l~i~D~~G~~~~~~~~~~~~~~~d~----~ilv 78 (168) T e2gjsa1 4 VLLLGAPGVGKSALARIFGGVEDGPEAEAAGHTYDRSIVVD-GEEASLMVYDIWEQDGGRWLPGHCMAMGDA----YVIV 78 (168) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCEEEEEEEEEEEEC-CEEEEEEEEEEEEECCCCCCCCCCCCCEEE----EEEE T ss_conf 99980799879999998835626752350688899999971-415799999753103210002001245289----9998 Q ss_pred HHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCCCCC Q ss_conf 21203247999999999999999972488889999999999999862035000577776766454566540000368887 Q Ver_Hs_NP_0061 137 ADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLGD 216 (492) Q Consensus 137 lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lPLge 216 (492) .|.+.+.++ +.+++|+..++++...-+ T Consensus 79 ~d~t~~~sf-~~~~~~~~~i~~~~~~~~---------------------------------------------------- 105 (168) T e2gjsa1 79 YSVTDKGSF-EKASELRVQLRRARQTDD---------------------------------------------------- 105 (168) T ss_pred EEECCCCCH-HHHHHHHHHHHHHHCCCC---------------------------------------------------- T ss_conf 640235545-677578899996211267---------------------------------------------------- Q ss_pred CCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHH Q ss_conf 6221479940799850752255554205774778999999999999870873788456663567999999988872 Q Ver_Hs_NP_0061 217 NVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTY 292 (492) Q Consensus 217 g~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~Hrly 292 (492) +|++||++|+|. .++-.+-++.+|.++-+|++..+.||++...|++-+...|+..+. T Consensus 106 --------~piiivgnK~Dl-----------~~~~~v~~~e~~~~~~~~~~~~~e~Sak~~~~i~~~f~~i~~~i~ 162 (168) T e2gjsa1 106 --------VPIILVGNKSDL-----------VRSREVSVDEGRACAVVFDCKFIETSAALHHNVQALFEGVVRQIR 162 (168) T ss_pred --------CCEEEEEECCCC-----------CCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHH T ss_conf --------504567531332-----------324567989999999965980899970589788899999999999 No 13 >2atx_A Small GTP binding protein TC10; GTPase, P-loop, alpha-beta; HET: GNP; 2.65A {Homo sapiens} SCOP: c.37.1.8 Probab=99.01 E-value=1.8e-08 Score=79.28 Aligned_columns=182 Identities=16% Q ss_pred CCCCCCCCCC-----EEEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCC Q ss_conf 7862278876-----48886078854899999862013367874310335302121347300100588567602113532 Q Ver_Hs_NP_0061 46 RARSKLPSGK-----NILVFGEDGSGKTTLMTKLQGAEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLK 120 (492) Q Consensus 46 ~~~~klp~~K-----nILvLG~~~sGKttLi~~Lq~~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk 120 (492) .+|+.+.++- .|+|+|+.++|||+|+.+|.+..-.......-...+.+.-...+..-++.+|-..|...+..+.+ T Consensus 5 ~~~~~~~~~~~~~~iKi~iiG~~~vGKTsli~~~~~~~~~~~~~~t~~~~~~~~i~~~~~~~~l~i~D~~g~~~~~~~~~ 84 (194) T 2atx_A 5 AGRSSMAHGPGALMLKCVVVGDGAVGKTCLLMSYANDAFPEEYVPTVFDHYAVSVTVGGKQYLLGLYDTAGQEDYDRLRP 84 (194) T ss_dssp ----CCSSCCEEEEEEEEEEECTTSSHHHHHHHHHHSSCCCSCCCSSCCCEEEEEESSSCEEEEEEECCCCSSSSTTTGG T ss_pred CCCCCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEECCCEEEEEEECCCCCCCCHHHHH T ss_conf 77742335865327889998179987899999986384377535416543445665349448887612532100001233 Q ss_pred CCCCCCCHHHEEEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCC Q ss_conf 24773433021020002120324799999999999999997248888999999999999986203500057777676645 Q Ver_Hs_NP_0061 121 FAVSAESLPETLVIFVADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGP 200 (492) Q Consensus 121 ~al~~~si~~TlVvI~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~ 200 (492) ..+.--+ .++|+.|++.++++-+-.+.|+..++.+..+ T Consensus 85 ~~~~~~~----~~ilV~d~~~~~sf~~~~~~~~~~~~~~~~~-------------------------------------- 122 (194) T 2atx_A 85 LSYPMTD----VFLICFSVVNPASFQNVKEEWVPELKEYAPN-------------------------------------- 122 (194) T ss_dssp GGCTTCS----EEEEEEETTCHHHHHHHHHTHHHHHHHHSTT-------------------------------------- T ss_pred HHHCCCE----EEECCCCCCHHHHHHHHHHHHHHHHHHCCCC-------------------------------------- T ss_conf 3202010----0200000104678888888766666530678-------------------------------------- Q ss_pred CCCCCCCHHCCCCCCCCCEECCCCCEEEEEEECCCHHHHHHHCCCCCH-HHHHHHHHHHHHHHHHCCCEEEE-ECCCCCC Q ss_conf 456654000036888762214799407998507522555542057747-78999999999999870873788-4566635 Q Ver_Hs_NP_0061 201 LTSGSDEENVALPLGDNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRD-EHLDFIQSHLRRFCLQYGAALIY-TSVKEEK 278 (492) Q Consensus 201 ~~s~~de~~v~lPLgeg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~d-E~fD~Iqq~LR~~cL~YGAsLiY-TS~ke~k 278 (492) +|+++|.+|+|..+.-+....+.+ ....+.....++||-++|+..++ ||++... T Consensus 123 ------------------------~~iilVgnK~Dl~~~~~~~~~~~~~~~~~v~~~e~~~~a~~~~~~~~~e~Sak~~~ 178 (194) T 2atx_A 123 ------------------------VPFLLIGTQIDLRDDPKTLARLNDMKEKPICVEQGQKLAKEIGACCYVECSALTQK 178 (194) T ss_dssp ------------------------CCEEEEEECTTSTTCHHHHHHHTTTTCCCCCHHHHHHHHHHHTCSCEEECCTTTCT T ss_pred ------------------------CCEEEEECCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEEEECCCC T ss_conf ------------------------53799862645554303677765520256378999999997189227897504887 Q ss_pred CHHHHHHHHHHHHHC Q ss_conf 679999999888727 Q Ver_Hs_NP_0061 279 NLDLLYKYIVHKTYG 293 (492) Q Consensus 279 Nl~lLykYi~Hrlyg 293 (492) |++-+..+++..+.. T Consensus 179 ~I~~~f~~li~~il~ 193 (194) T 2atx_A 179 GLKTVFDEAIIAILT 193 (194) T ss_dssp THHHHHHHHHHHHHC T ss_pred CHHHHHHHHHHHHHC T ss_conf 888999999999707 No 14 >1oix_A RAS-related protein RAB-11A; small G protein, intracellular trafficking, GTP-binding, lipoprotein, prenylation, protein transport; HET: GDP; 1.7A {Homo sapiens} SCOP: c.37.1.8 Probab=99.00 E-value=1.1e-07 Score=73.95 Aligned_columns=159 Identities=21% Q ss_pred EEEEECCCCCHHHHHHHHHCCC-CCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEEEE Q ss_conf 8886078854899999862013-367874310335302121347300100588567602113532247734330210200 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTKLQGAE-HGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLVIF 135 (492) Q Consensus 57 ILvLG~~~sGKttLi~~Lq~~e-~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlVvI 135 (492) |+|+|+.++|||||+.+|.+.. ....-...+..+..+.-...+..-.+.+|...|......+.+..+..-++ +++ T Consensus 32 I~iiG~~~vGKSSLi~~l~~~~~~~~~~~t~~~~~~~~~~~~~~~~~~~~i~d~~g~~~~~~~~~~~~~~~d~----iil 107 (191) T 1oix_A 32 VVLIGDSGVGKSNLLSRFTRNEFNLESKSTIGVEFATRSIQVDGKTIKAQIWDTAGLERYRAITSAYYRGAVG----ALL 107 (191) T ss_dssp EEEEECTTSSHHHHHHHHHHSCCCCSCCCCCSEEEEEEEEEETTEEEEEEEEEECSCCSSSCCCHHHHTTCCE----EEE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECEEEEEEEECCCCCHHHHHHHHHHCCCCCE----EEE T ss_conf 9998179977899999986482564443321220110268750213444551477720234567764136765----899 Q ss_pred HHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCCCC Q ss_conf 02120324799999999999999997248888999999999999986203500057777676645456654000036888 Q Ver_Hs_NP_0061 136 VADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLG 215 (492) Q Consensus 136 ~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lPLg 215 (492) |.|.+.+ .-++.+.+|...+...... T Consensus 108 v~d~~~~-~S~~~~~~~~~~i~~~~~~----------------------------------------------------- 133 (191) T 1oix_A 108 VYDIAKH-LTYENVERWLKELRDHADS----------------------------------------------------- 133 (191) T ss_dssp EEETTCH-HHHHTHHHHHHHHHHHSCT----------------------------------------------------- T ss_pred EEEECCC-CCHHHHHHHHHHHHHHCCC----------------------------------------------------- T ss_conf 9750775-3068999988877763289----------------------------------------------------- Q ss_pred CCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHH Q ss_conf 76221479940799850752255554205774778999999999999870873788456663567999999988872 Q Ver_Hs_NP_0061 216 DNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTY 292 (492) Q Consensus 216 eg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~Hrly 292 (492) .+|+++|++|+| |.+++.-..++ ++.||-+++...+.||++...|++-+...|+..+| T Consensus 134 --------~~piiivgnK~D----l~~~~~i~~~e-------~~~~~~~~~~~~~evSak~~~~I~elf~~i~~~iy 191 (191) T 1oix_A 134 --------NIVIMLVGNKSD----LRHLRAVPTDE-------ARAFAEKNGLSFIETSALDSTNVEAAFQTILTEIY 191 (191) T ss_dssp --------TCEEEEEEECGG----GGGGCCSCHHH-------HHHHHHHTTCEEEECCTTTCTTHHHHHHHHHHHHC T ss_pred --------CCEEEEEECCCC----CCCCCCCCHHH-------HHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCC T ss_conf --------977999841433----00003688899-------99999963993899961688688899999999709 No 15 >1ek0_A GTP-binding protein YPT51; vesicular traffic, GTP hydrolysis, YPT/RAB protein, endocytosis, hydrolase; HET: MHO GNP GDP; 1.48A {Saccharomyces cerevisiae} SCOP: c.37.1.8 Probab=98.99 E-value=6.2e-08 Score=75.76 Aligned_columns=162 Identities=19% Q ss_pred EEEEEECCCCCHHHHHHHHHCCC-CCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEEE Q ss_conf 48886078854899999862013-36787431033530212134730010058856760211353224773433021020 Q Ver_Hs_NP_0061 56 NILVFGEDGSGKTTLMTKLQGAE-HGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLVI 134 (492) Q Consensus 56 nILvLG~~~sGKttLi~~Lq~~e-~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlVv 134 (492) .|+|+|+.++|||||+.+|.+.+ ........+--|....-...+..-++.+|-..|...+..+.+.....-.+ ++ T Consensus 5 ki~ivG~~~vGKSsLi~~~~~~~~~~~~~~t~~~~~~~~~~~~~~~~~~l~i~d~~g~~~~~~~~~~~~~~~~~----~i 80 (170) T 1ek0_A 5 KLVLLGEAAVGKSSIVLRFVSNDFAENKEPTIGAAFLTQRVTINEHTVKFEIWDTAGQERFASLAPXYYRNAQA----AL 80 (170) T ss_dssp EEEEECSTTSSHHHHHHHHHHSCCCTTCCCCSSEEEEEEEEEETTEEEEEEEEEECCSGGGGGGHHHHHTTCSE----EE T ss_pred EEEEECCCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEECCCCCCCCCEEEECCCCCHHHHHHHHHHCCCCCE----EE T ss_conf 89988179977899999986483465534310234554200012234302430344511232220111256503----78 Q ss_pred EHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCCC Q ss_conf 00212032479999999999999999724888899999999999998620350005777767664545665400003688 Q Ver_Hs_NP_0061 135 FVADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPL 214 (492) Q Consensus 135 I~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lPL 214 (492) ||.|.+.|..+ +++..|+..+.....+.. T Consensus 81 ~v~d~~~~~s~-~~~~~~~~~~~~~~~~~~-------------------------------------------------- 109 (170) T 1ek0_A 81 VVYDVTKPQSF-IKARHWVKELHEQASKDI-------------------------------------------------- 109 (170) T ss_dssp EEEETTCHHHH-HHHHHHHHHHHHHSCTTC-------------------------------------------------- T ss_pred EEEECCCCCHH-HHHHHHHHHHHHHCCCCC-------------------------------------------------- T ss_conf 99702365045-566788888864113564-------------------------------------------------- Q ss_pred CCCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHH Q ss_conf 87622147994079985075225555420577477899999999999987087378845666356799999998887 Q Ver_Hs_NP_0061 215 GDNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKT 291 (492) Q Consensus 215 geg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~Hrl 291 (492) |++||++|+|..+.-..+.-..++ ++.||-.+++..+.||++...+++-+...|.+.+ T Consensus 110 -----------~iivv~nK~D~~~~~~~~~v~~~~--------~~~~~~~~~~~~~e~Sa~~~~gi~elf~~i~~~i 167 (170) T 1ek0_A 110 -----------IIALVGNKIDXLQEGGERKVAREE--------GEKLAEEKGLLFFETSAKTGENVNDVFLGIGEKI 167 (170) T ss_dssp -----------EEEEEEECGGGGGSSCCCCSCHHH--------HHHHHHHHTCEEEECCTTTCTTHHHHHHHHHTTS T ss_pred -----------CEEEEECCCCCCCHHHHHHHHHHH--------HHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHH T ss_conf -----------334541153100000001100789--------9999986598399986268868889999999970 No 16 >e1xtqa1 c.37.1.8 (A:3-169) GTP-binding protein RheB {Human (Homo sapiens) [TaxID:9606]} SCOP: u1xtsa_ u1xtra_ Probab=98.98 E-value=4.4e-08 Score=76.72 Aligned_columns=159 Identities=16% Q ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEEEEH Q ss_conf 88860788548999998620133678743103353021213473001005885676021135322477343302102000 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTKLQGAEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLVIFV 136 (492) Q Consensus 57 ILvLG~~~sGKttLi~~Lq~~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlVvI~ 136 (492) |+|+|+.++|||+|+.++.+-+-.......--..+...-...+...++.+|-..|.-.+..+.+....--+ .+++| T Consensus 7 i~ivG~~~vGKTsLi~~~~~~~~~~~~~~t~~~~~~~~~~~~~~~~~l~~~d~~g~~~~~~~~~~~~~~~d----~~ilv 82 (167) T e1xtqa1 7 IAILGYRSVGKSSLTIQFVEGQFVDSYDPTIENTFTKLITVNGQEYHLQLVDTAGQDEYSIFPQTYSIDIN----GYILV 82 (167) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEECCEEEEEEEEEECCCCCCCCCCCCCCCCCE----EEEEE T ss_conf 89981699879999999863811677344055310799998248999999850362334345511145402----79998 Q ss_pred HHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCCCCC Q ss_conf 21203247999999999999999972488889999999999999862035000577776766454566540000368887 Q Ver_Hs_NP_0061 137 ADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLGD 216 (492) Q Consensus 137 lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lPLge 216 (492) .|.+.|.+| +.++.|+.-+.++..+.+ T Consensus 83 ~d~~~~~sf-~~~~~~~~~i~~~~~~~~---------------------------------------------------- 109 (167) T e1xtqa1 83 YSVTSIKSF-EVIKVIHGKLLDMVGKVQ---------------------------------------------------- 109 (167) T ss_pred EEECCCCCH-HHHHHHHHHHHHHHCCCC---------------------------------------------------- T ss_conf 641232102-356777789986412578---------------------------------------------------- Q ss_pred CCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHH Q ss_conf 622147994079985075225555420577477899999999999987087378845666356799999998887 Q Ver_Hs_NP_0061 217 NVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKT 291 (492) Q Consensus 217 g~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~Hrl 291 (492) +|+++|++|+|. .++..+-.+-++.|+-++++..+.||++...|++-+.+.|++.. T Consensus 110 --------~piiivgnK~Dl-----------~~~~~v~~~~~~~~~~~~~~~~~e~Sak~~~~v~e~f~~li~~~ 165 (167) T e1xtqa1 110 --------IPIMLVGNKKDL-----------HMERVISYEEGKALAESWNAAFLESSAKENQTAVDVFRRIILEA 165 (167) T ss_pred --------CCEEEEEECCCC-----------CCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHH T ss_conf --------618998613464-----------22246898999999995598299997158977789999999998 No 17 >2oil_A CATX-8, RAS-related protein RAB-25; G-protein, GDP, structural genomics, structural genomics consortium, SGC; HET: GDP; 2.30A {Homo sapiens} Probab=98.97 E-value=3.4e-08 Score=77.54 Aligned_columns=170 Identities=19% Q ss_pred CCCCCCCCCCE-------EEEEECCCCCHHHHHHHHHCCC-CCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCC Q ss_conf 78622788764-------8886078854899999862013-367874310335302121347300100588567602113 Q Ver_Hs_NP_0061 46 RARSKLPSGKN-------ILVFGEDGSGKTTLMTKLQGAE-HGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKG 117 (492) Q Consensus 46 ~~~~klp~~Kn-------ILvLG~~~sGKttLi~~Lq~~e-~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~ 117 (492) +|.+-+|-|.+ |+|+|+.++||||||.+|.+.+ ...-..-.+..+....-...+..-++.+|...|.-.... T Consensus 10 ~~~~~~~r~~~~~d~~~KI~iiG~~~vGKSSli~~l~~~~~~~~~~~t~~~~~~~~~~~~~~~~~~l~i~d~~g~~~~~~ 89 (193) T 2oil_A 10 HSSGLVPRGSEDYNFVFKVVLIGESGVGKTNLLSRFTRNEFSHDSRTTIGVEFSTRTVMLGTAAVKAQIWDTAGLERYRA 89 (193) T ss_dssp ----------CCCSEEEEEEEESSTTSSHHHHHHHHHHSCCCSSCCCCSSEEEEEEEEEETTEEEEEEEEEESCCCTTCT T ss_pred CCCCCCCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEECCEEEEEEEECCCCCHHHCC T ss_conf 45677889986754578999980799879999999865811576356146667777887656566667614667001100 Q ss_pred CCCCCCCCCCHHHEEEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCC Q ss_conf 53224773433021020002120324799999999999999997248888999999999999986203500057777676 Q Ver_Hs_NP_0061 118 LLKFAVSAESLPETLVIFVADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQR 197 (492) Q Consensus 118 LLk~al~~~si~~TlVvI~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r 197 (492) +.+..+..-+ .+++|.|.+.+..+ +.+..|+.-++.+... T Consensus 90 ~~~~~~~~~~----~~i~v~d~~~~~s~-~~~~~~~~~i~~~~~~----------------------------------- 129 (193) T 2oil_A 90 ITSAYYRGAV----GALLVFDLTKHQTY-AVVERWLKELYDHAEA----------------------------------- 129 (193) T ss_dssp THHHHHTTCC----EEEEEEETTCHHHH-HTHHHHHHHHHTTSCT----------------------------------- T ss_pred CHHCCCCCCE----EEEEEEEECCCCHH-HHHHHHHHHHHHCCCC----------------------------------- T ss_conf 0002256752----79999750340000-0111100122100356----------------------------------- Q ss_pred CCCCCCCCCCHHCCCCCCCCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCC Q ss_conf 64545665400003688876221479940799850752255554205774778999999999999870873788456663 Q Ver_Hs_NP_0061 198 RGPLTSGSDEENVALPLGDNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEE 277 (492) Q Consensus 198 ~~~~~s~~de~~v~lPLgeg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~ 277 (492) .+|+++|++|+|. .++-++..+.++.+|-.++...+.||++.. T Consensus 130 --------------------------~~piilv~nK~Dl-----------~~~~~v~~~~~~~~~~~~~~~~~~~Sak~~ 172 (193) T 2oil_A 130 --------------------------TIVVMLVGNKSDL-----------SQAREVPTEEARMFAENNGLLFLETSALDS 172 (193) T ss_dssp --------------------------TCEEEEEEECGGG-----------GGGCCSCHHHHHHHHHHTTCEEEEECTTTC T ss_pred --------------------------CEEEEEEECCHHH-----------HHHHCCHHHHHHHHHHHCCCEEEEEECCCC T ss_conf --------------------------1344332132022-----------333111367778999865972999862689 Q ss_pred CCHHHHHHHHHHHHH Q ss_conf 567999999988872 Q Ver_Hs_NP_0061 278 KNLDLLYKYIVHKTY 292 (492) Q Consensus 278 kNl~lLykYi~Hrly 292 (492) .|++-+..+|+..+| T Consensus 173 ~~I~elf~~i~~~i~ 187 (193) T 2oil_A 173 TNVELAFETVLKEIF 187 (193) T ss_dssp TTHHHHHHHHHHHHH T ss_pred CCHHHHHHHHHHHHH T ss_conf 788899999999999 No 18 >1x3s_A RAS-related protein RAB-18; GTPase, GNP, structural genomics, NPPSFA, national project on protein structural and functional analyses; HET: GNP; 1.32A {Homo sapiens} SCOP: c.37.1.8 Probab=98.97 E-value=1.3e-07 Score=73.62 Aligned_columns=160 Identities=26% Q ss_pred EEEEEECCCCCHHHHHHHHHCCC-CCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEEE Q ss_conf 48886078854899999862013-36787431033530212134730010058856760211353224773433021020 Q Ver_Hs_NP_0061 56 NILVFGEDGSGKTTLMTKLQGAE-HGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLVI 134 (492) Q Consensus 56 nILvLG~~~sGKttLi~~Lq~~e-~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlVv 134 (492) .|+|+|..++|||||+.+|.+.+ ...-....+..+....-...+...++.+|-..|...+..+.+..+.. -..+| T Consensus 17 KI~viG~~~vGKTsLi~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~i~D~~~~~~~~~~~~~~~~~----~~~~i 92 (195) T 1x3s_A 17 KILIIGESGVGKSSLLLRFTDDTFDPELAATIGVDFKVKTISVDGNKAKLAIWDTAGQERFRTLTPSYYRG----AQGVI 92 (195) T ss_dssp EEEEECSTTSSHHHHHHHHHHSCCCTTCCCCCSEEEEEEEEEETTEEEEEEEEEECSSGGGCCSHHHHHTT----CCEEE T ss_pred EEEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEEECCEEEEEEEECCCCHHHHHHHHHHHHCC----CCCEE T ss_conf 68998069987999999986581365533202211257888887878898850032200223343777225----88128 Q ss_pred EHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCCC Q ss_conf 00212032479999999999999999724888899999999999998620350005777767664545665400003688 Q Ver_Hs_NP_0061 135 FVADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPL 214 (492) Q Consensus 135 I~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lPL 214 (492) ||.|.+.+..+-. +..|+..++ T Consensus 93 ~v~d~~~~~S~~~-~~~~~~~i~--------------------------------------------------------- 114 (195) T 1x3s_A 93 LVYDVTRRDTFVK-LDNWLNELE--------------------------------------------------------- 114 (195) T ss_dssp EEEETTCHHHHHT-HHHHHHHHT--------------------------------------------------------- T ss_pred EEEECCCCCCHHH-HHHHHHHHH--------------------------------------------------------- T ss_conf 9972367410112-478887665--------------------------------------------------------- Q ss_pred CCCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHH Q ss_conf 876221479940799850752255554205774778999999999999870873788456663567999999988872 Q Ver_Hs_NP_0061 215 GDNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTY 292 (492) Q Consensus 215 geg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~Hrly 292 (492) ....+..+|++||++|+| |+.+.-..++ ++.|+-+++..++.||++...|++-+...+++.++ T Consensus 115 ---~~~~~~~~piiiv~nK~D----l~~~~v~~~~--------~~~~~~~~~~~~~e~Sa~~~~gi~~~f~~i~~~i~ 177 (195) T 1x3s_A 115 ---TYCTRNDIVNMLVGNKID----KENREVDRNE--------GLKFARKHSMLFIEASAKTCDGVQCAFEELVEKII 177 (195) T ss_dssp ---TCCSCSCCEEEEEEECTT----SSSCCSCHHH--------HHHHHHHTTCEEEECCTTTCTTHHHHHHHHHHHHH T ss_pred ---HHCCCCCCEEEEECCCCC----HHHCCCHHHH--------HHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHH T ss_conf ---410124530677426520----0110101789--------99999962987999851678788899999999997 No 19 >2fg5_A RAB-22B, RAS-related protein RAB-31; G-protein, GTP analogue, structural genomics, structural genomics consortium, SGC; HET: GNP; 2.80A {Homo sapiens} SCOP: c.37.1.8 Probab=98.95 E-value=6.7e-08 Score=75.54 Aligned_columns=156 Identities=23% Q ss_pred EEEEECCCCCHHHHHHHHHC---CCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEE Q ss_conf 88860788548999998620---133678743103353021213473001005885676021135322477343302102 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTKLQG---AEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLV 133 (492) Q Consensus 57 ILvLG~~~sGKttLi~~Lq~---~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlV 133 (492) |+|+|+.++|||||+.+|.+ .+.....-+.+|....... .+..-++.+|-..+.-....+.+.... .-..+ T Consensus 26 I~iiG~~~vGKSsLi~~l~~~~~~~~~~~T~~~~~~~~~~~~--~~~~~~~~i~d~~~~~~~~~~~~~~~~----~~~~~ 99 (192) T 2fg5_A 26 VCLLGDTGVGKSSIVCRFVQDHFDHNISPTIGASFMTKTVPC--GNELHKFLIWDTAGQERFHSLAPMYYR----GSAAA 99 (192) T ss_dssp EEEEECTTSSHHHHHHHHHHCCCCTTCCCCSSEEEEEEEEEC--SSSEEEEEEEEECCSGGGGGGTHHHHT----TCSEE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEECC--CCEEEEEECCCCCHHHHHHHHHHHHHH----HHHHE T ss_conf 999806997689999998728106776762233456664104--650111000001002355678888763----11100 Q ss_pred EEHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCC Q ss_conf 00021203247999999999999999972488889999999999999862035000577776766454566540000368 Q Ver_Hs_NP_0061 134 IFVADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALP 213 (492) Q Consensus 134 vI~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lP 213 (492) +++.|.+.+..+ +++..|+..+++... T Consensus 100 i~v~d~~~~~s~-~~i~~~~~~i~~~~~---------------------------------------------------- 126 (192) T 2fg5_A 100 VIVYDITKQDSF-YTLKKWVKELKEHGP---------------------------------------------------- 126 (192) T ss_dssp EEEEETTCTHHH-HHHHHHHHHHHHHSC---------------------------------------------------- T ss_pred EEEECCCCHHHH-HHHHHHHHHHHHHCC---------------------------------------------------- T ss_conf 122103440568-999999999987258---------------------------------------------------- Q ss_pred CCCCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHH Q ss_conf 887622147994079985075225555420577477899999999999987087378845666356799999998887 Q Ver_Hs_NP_0061 214 LGDNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKT 291 (492) Q Consensus 214 Lgeg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~Hrl 291 (492) ..+|++||++|+|. .++-..+.+.++.||-++++.++.||++...|++-+..+|+..+ T Consensus 127 ---------~~~~iilVgnK~Dl-----------~~~~~~~~~~~~~~~k~~~~~~~evSak~g~gV~elf~~i~~~i 184 (192) T 2fg5_A 127 ---------ENIVMAIAGNKCDL-----------SDIREVPLKDAKEYAESIGAIVVETSAKNAINIEELFQGISRQI 184 (192) T ss_dssp ---------TTCEEEEEEECGGG-----------GGGCCSCHHHHHHHHHTTTCEEEECBTTTTBSHHHHHHHHHHTC T ss_pred ---------CCCEEEEEECCCCH-----------HHHCCCCHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHC T ss_conf ---------97068885052200-----------01104547899999996398599985268978889999999864 No 20 >2p5s_A RAS and EF-hand domain containing; G-protein, RAB, GDP, structural genomics, SGC, structural genomics consortium; HET: GDP; 2.15A {Homo sapiens} Probab=98.95 E-value=6.4e-09 Score=82.37 Aligned_columns=164 Identities=20% Q ss_pred EEEEECCCCCHHHHHHHHHCCCCCCC-CCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEEEE Q ss_conf 88860788548999998620133678-74310335302121347300100588567602113532247734330210200 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTKLQGAEHGKK-GRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLVIF 135 (492) Q Consensus 57 ILvLG~~~sGKttLi~~Lq~~e~~kk-g~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlVvI 135 (492) |+|+|..++||||||.+|.+.+.... ...++..+....=...+....+.+|-..|...+..+.+.....- ..+|+ T Consensus 31 I~ivG~~~vGKSsLi~~l~~~~~~~~~~~t~~~~~~~~~i~~~~~~~~l~i~d~~~~~~~~~~~~~~~~~~----d~~il 106 (199) T 2p5s_A 31 IVLAGDAAVGKSSFLMRLCKNEFRENISATLGVDFQMKTLIVDGERTVLQLWDTAGQERFRSIAKSYFRKA----DGVLL 106 (199) T ss_dssp EEEESSTTSSHHHHHHHHHHCCCC----------CEEEEEEETTEEEEEEEEECTTCTTCHHHHHHHHHHC----SEEEE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEEECCCEEEEEEECCCCHHHHHHHHHHHHHHH----CCEEE T ss_conf 99980799879999999865812565145402467888874156214564202541245567889875330----02243 Q ss_pred HHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCCCC Q ss_conf 02120324799999999999999997248888999999999999986203500057777676645456654000036888 Q Ver_Hs_NP_0061 136 VADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLG 215 (492) Q Consensus 136 ~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lPLg 215 (492) |.|.+.|..+ +.+..|+..++++... T Consensus 107 v~d~~~~~s~-~~~~~~~~~i~~~~~~----------------------------------------------------- 132 (199) T 2p5s_A 107 LYDVTCEKSF-LNIREWVDMIEDAAHE----------------------------------------------------- 132 (199) T ss_dssp EEETTCHHHH-HTHHHHHHHHHHHC------------------------------------------------------- T ss_pred EEHHCCHHHH-HHHHCCCCCCCCCCCC----------------------------------------------------- T ss_conf 2001020233-3321000121113689----------------------------------------------------- Q ss_pred CCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHH Q ss_conf 7622147994079985075225555420577477899999999999987087378845666356799999998887 Q Ver_Hs_NP_0061 216 DNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKT 291 (492) Q Consensus 216 eg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~Hrl 291 (492) ++||+||.+|+|.. +....+++-.+.+...+.++-++++..+.||++...+++-+...|.|.+ T Consensus 133 --------~~Piiiv~nK~Dl~-----~~~~~~~~~~i~~~~~~~~a~~~~~~~~~~Sak~g~gi~e~f~~i~~~i 195 (199) T 2p5s_A 133 --------TVPIMLVGNKADIR-----DTAATEGQKCVPGHFGEKLAMTYGALFCETSAKDGSNIVEAVLHLAREV 195 (199) T ss_dssp ---------CCEEEEEECGGGH-----HHHHHTTCCCCCHHHHHHHHHHHTCEEEECCTTTCTTHHHHHHHHHHHH T ss_pred --------CCEEEEEECCCCHH-----HHHHHHHHHCCCHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHH T ss_conf --------72798821125602-----3444444313468899999985598699985257988899999999999 No 21 >e2erxa1 c.37.1.8 (A:6-176) di-Ras2 {Human (Homo sapiens) [TaxID:9606]} SCOP: u2erxb_ u2gf0c_ u2gf0d_ u2gf0a1 u2gf0b_ Probab=98.95 E-value=1.2e-07 Score=73.88 Aligned_columns=159 Identities=21% Q ss_pred EEEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEEEE Q ss_conf 48886078854899999862013367874310335302121347300100588567602113532247734330210200 Q Ver_Hs_NP_0061 56 NILVFGEDGSGKTTLMTKLQGAEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLVIF 135 (492) Q Consensus 56 nILvLG~~~sGKttLi~~Lq~~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlVvI 135 (492) .|+|+|+.++||||||.+|.+-.-...-...--......-......-++.+|...|...+..+.+.....- ..+++ T Consensus 4 kI~vvG~~~vGKTsli~~~~~~~~~~~~~~t~~~~~~~~~~~~~~~~~~~i~d~~g~~~~~~~~~~~~~~~----~~~i~ 79 (171) T e2erxa1 4 RVAVFGAGGVGKSSLVLRFVKGTFRESYIPTVEDTYRQVISCDKSICTLQITDTTGSHQFPAMQRLSISKG----HAFIL 79 (171) T ss_pred EEEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEECCEEEEEEEEECCCCHHHHHHHHHHCCCC----CEEEE T ss_conf 89998079987999999986382166624302200257998746478999973056102334302211587----26999 Q ss_pred HHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCCCC Q ss_conf 02120324799999999999999997248888999999999999986203500057777676645456654000036888 Q Ver_Hs_NP_0061 136 VADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLG 215 (492) Q Consensus 136 ~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lPLg 215 (492) |.|.+.++++ +.+..|.+-+++.-.... T Consensus 80 v~d~~~~~s~-~~~~~~~~~l~~~~~~~~--------------------------------------------------- 107 (171) T e2erxa1 80 VYSITSRQSL-EELKPIYEQICEIKGDVE--------------------------------------------------- 107 (171) T ss_pred EECCCCCCCH-HHHHHHHHHHHHHHCCCC--------------------------------------------------- T ss_conf 9717742007-899999754666402678--------------------------------------------------- Q ss_pred CCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHH Q ss_conf 76221479940799850752255554205774778999999999999870873788456663567999999988 Q Ver_Hs_NP_0061 216 DNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVH 289 (492) Q Consensus 216 eg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~H 289 (492) ++|++||++|+| |..+.....|+. +.||-++|+.++.||++...+++-+.+.|++ T Consensus 108 --------~~piiivgnK~D----l~~~~~i~~~~~-------~~~~~~~~~~~~~~Sak~g~gi~e~f~~i~~ 162 (171) T e2erxa1 108 --------SIPIMLVGNKCD----ESPSREVQSSEA-------EALARTWKCAFMETSAKLNHNVKELFQELLN 162 (171) T ss_pred --------CCCEEEEEECCC----CCCCCCCCHHHH-------HHHHHHCCCCEEEEECCCCCCHHHHHHHHHH T ss_conf --------852799973135----663335447899-------9999964992899970589687899999999 No 22 >e2a5ja1 c.37.1.8 (A:9-181) Rab2b {Human (Homo sapiens) [TaxID:9606]} SCOP: u1z0aa1 u1z0ad_ u1z0ab_ Probab=98.92 E-value=1.3e-07 Score=73.62 Aligned_columns=159 Identities=18% Q ss_pred EEEEECCCCCHHHHHHHHHCCC-CCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEEEE Q ss_conf 8886078854899999862013-367874310335302121347300100588567602113532247734330210200 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTKLQGAE-HGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLVIF 135 (492) Q Consensus 57 ILvLG~~~sGKttLi~~Lq~~e-~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlVvI 135 (492) |+|+|+.++|||+||.++.+.. ....-...+..+....-...+...++.+|-..|...+..+.+..+.. ...+++ T Consensus 6 V~ivG~~~vGKTsLi~~~~~~~~~~~~~~t~~~~~~~~~~~~~~~~~~l~i~d~~g~~~~~~~~~~~~~~----~d~~i~ 81 (173) T e2a5ja1 6 YIIIGDTGVGKSCLLLQFTDKRFQPVHDLTIGVEFGARMVNIDGKQIKLQIWDTAGQESFRSITRSYYRG----AAGALL 81 (173) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEECCCCCCEECCCEEEEEEEECCCCCCCCCHHHHHHCC----CCEEEE T ss_conf 9998369977999999986483466634135520010111015852799986147853110000555048----976899 Q ss_pred HHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCCCC Q ss_conf 02120324799999999999999997248888999999999999986203500057777676645456654000036888 Q Ver_Hs_NP_0061 136 VADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLG 215 (492) Q Consensus 136 ~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lPLg 215 (492) |.|.+.+..+ +.+.+|..-+.....+- T Consensus 82 v~d~~~~~s~-~~~~~~~~~i~~~~~~~---------------------------------------------------- 108 (173) T e2a5ja1 82 VYDITRRETF-NHLTSWLEDARQHSSSN---------------------------------------------------- 108 (173) T ss_pred EEECCCHHHH-HHHHHHHHHHHHHCCCC---------------------------------------------------- T ss_conf 9742651467-89888899988521676---------------------------------------------------- Q ss_pred CCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHH Q ss_conf 76221479940799850752255554205774778999999999999870873788456663567999999988872 Q Ver_Hs_NP_0061 216 DNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTY 292 (492) Q Consensus 216 eg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~Hrly 292 (492) .|++||++|+|. .++-.+-++.++.+|-+++...+.||++...|++-+...+.+.+| T Consensus 109 ---------~p~iivgnK~Dl-----------~~~~~v~~~~~~~~~~~~~~~~~e~Saktg~gv~e~F~~l~~~i~ 165 (173) T e2a5ja1 109 ---------MVIMLIGNKSDL-----------ESRRDVKREEGEAFAREHGLIFMETSAKTACNVEEAFINTAKEIY 165 (173) T ss_pred ---------CEEEEEECCCCC-----------HHHCCCCHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHH T ss_conf ---------123221011244-----------101032088999999964984999851689888899999999999 No 23 >d1g16a_ c.37.1.8 (A:) Rab-related protein Sec4 {Baker's yeast (Saccharomyces cerevisiae)} Probab=98.92 E-value=2.2e-07 Score=72.08 Aligned_columns=159 Identities=18% Q ss_pred EEEEEECCCCCHHHHHHHHHCCC-CCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEEE Q ss_conf 48886078854899999862013-36787431033530212134730010058856760211353224773433021020 Q Ver_Hs_NP_0061 56 NILVFGEDGSGKTTLMTKLQGAE-HGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLVI 134 (492) Q Consensus 56 nILvLG~~~sGKttLi~~Lq~~e-~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlVv 134 (492) .|+|+|..++|||||+.+|.+.+ .......++..|....-...+...++.+|-..|...+..+.+..+.. --.++ T Consensus 4 Ki~ivG~~~vGKTsLi~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~i~d~~g~~~~~~~~~~~~~~----~d~~i 79 (166) T d1g16a_ 4 KILLIGDSGVGKSCLLVRFVEDKFNPSFITTIGIDFKIKTVDINGKKVKLQIWDTAGQERFRTITTAYYRG----AMGII 79 (166) T ss_dssp EEEEEESTTSSHHHHHHHHHHCCCCC-------CCEEEEEEESSSCEEEEEEECCTTGGGTSCCCHHHHTT----EEEEE T ss_pred EEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEECCCCEEEEEEECCCCCCCCCHHHHHCCC----CCEEE T ss_conf 89998079987999999986480077624454114688899875841368872057832000012433269----96899 Q ss_pred EHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCCC Q ss_conf 00212032479999999999999999724888899999999999998620350005777767664545665400003688 Q Ver_Hs_NP_0061 135 FVADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPL 214 (492) Q Consensus 135 I~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lPL 214 (492) +|.|.+.|..+ +.+++|+..++.. T Consensus 80 ~v~d~~~~~s~-~~~~~~~~~i~~~------------------------------------------------------- 103 (166) T d1g16a_ 80 LVYDITDERTF-TNIKQWFKTVNEH------------------------------------------------------- 103 (166) T ss_dssp EEEETTCHHHH-HTHHHHHHHHHHH------------------------------------------------------- T ss_pred EEEECCCCCHH-HHHHHHHHHHHHC------------------------------------------------------- T ss_conf 99851565338-8999999998612------------------------------------------------------- Q ss_pred CCCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHH Q ss_conf 876221479940799850752255554205774778999999999999870873788456663567999999988872 Q Ver_Hs_NP_0061 215 GDNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTY 292 (492) Q Consensus 215 geg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~Hrly 292 (492) ..-++|++||.+|+| |+++.-..+| ++.|+-++|...+-||++...|++-+...|.+.++ T Consensus 104 ------~~~~~piivv~nK~D----l~~~~v~~~e--------~~~~~~~~~~~~~e~Sa~~g~gv~~lf~~l~~~i~ 163 (166) T d1g16a_ 104 ------ANDEAQLLLVGNKSD----METRVVTADQ--------GEALAKELGIPFIESSAKNDDNVNEIFFTLAKLIQ 163 (166) T ss_dssp ------SCTTCEEEEEEECTT----CTTCCSCHHH--------HHHHHHHHTCCEEECBTTTTBSHHHHHHHHHHHHH T ss_pred ------CCCCCCEEEEEECHH----HHHCCCCHHH--------HHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHH T ss_conf ------689851666763102----2200675889--------99999965993999961589888899999999999 No 24 >e2atxa1 c.37.1.8 (A:9-193) RhoQ {Human (Homo sapiens) [TaxID:9606]} SCOP: u2atxb_ Probab=98.91 E-value=1e-07 Score=74.27 Aligned_columns=172 Identities=15% Q ss_pred EEEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEEEE Q ss_conf 48886078854899999862013367874310335302121347300100588567602113532247734330210200 Q Ver_Hs_NP_0061 56 NILVFGEDGSGKTTLMTKLQGAEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLVIF 135 (492) Q Consensus 56 nILvLG~~~sGKttLi~~Lq~~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlVvI 135 (492) .|+|+|+.++|||||+.+|.+.+-...............-...+..-++.+|-..|...+..+.+..+..-+ +++| T Consensus 11 ki~viG~~~vGKTsli~~~~~~~~~~~~~~t~~~~~~~~i~~~~~~~~l~i~D~~g~~~~~~~~~~~~~~~d----~~i~ 86 (185) T e2atxa1 11 KCVVVGDGAVGKTCLLMSYANDAFPEEYVPTVFDHYAVSVTVGGKQYLLGLYDTAGQEDYDRLRPLSYPMTD----VFLI 86 (185) T ss_pred EEEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEECCCEEEEEEEECCCCCHHHHHHHHHCCCCE----EEEE T ss_conf 999980699889999999863832676355168888899987396489998505573112333454314342----5678 Q ss_pred HHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCCCC Q ss_conf 02120324799999999999999997248888999999999999986203500057777676645456654000036888 Q Ver_Hs_NP_0061 136 VADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLG 215 (492) Q Consensus 136 ~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lPLg 215 (492) |.|.+.|++|-+-.+.|+..++.+-.. T Consensus 87 v~D~~~~~S~~~~~~~~~~~~~~~~~~----------------------------------------------------- 113 (185) T e2atxa1 87 CFSVVNPASFQNVKEEWVPELKEYAPN----------------------------------------------------- 113 (185) T ss_pred EEECCCCCHHHHHHHHHHHHHHHHCCC----------------------------------------------------- T ss_conf 874357402788778889999860797----------------------------------------------------- Q ss_pred CCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHH-HHHHHHHHHHHHHHHCCCEEEE-ECCCCCCCHHHHHHHHHHHHHC Q ss_conf 7622147994079985075225555420577477-8999999999999870873788-4566635679999999888727 Q Ver_Hs_NP_0061 216 DNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDE-HLDFIQSHLRRFCLQYGAALIY-TSVKEEKNLDLLYKYIVHKTYG 293 (492) Q Consensus 216 eg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE-~fD~Iqq~LR~~cL~YGAsLiY-TS~ke~kNl~lLykYi~Hrlyg 293 (492) +|+++|.+|+|..+.-......+++ +..+-++..+.+|-++|+-.+| ||++...|++-+...+++-.+. T Consensus 114 ---------~piiivgnK~Dl~~~~~~~~~~~~~~~~~v~~~~~~~~a~~~~~~~~~e~Sa~t~~gi~e~fe~~i~~~l~ 184 (185) T e2atxa1 114 ---------VPFLLIGTQIDLRDDPKTLARLNDMKEKPICVEQGQKLAKEIGACCYVECSALTQKGLKTVFDEAIIAILT 184 (185) T ss_pred ---------CEEEEEEECCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHCC T ss_conf ---------07999972358765124666554411466788999999997089137887505787878999999999608 No 25 >cd00154 Rab Rab family. Rab GTPases form the largest family within the Ras superfamily. There are at least 60 Rab genes in the human genome, and a number of Rab GTPases are conserved from yeast to humans. Rab GTPases are small, monomeric proteins that function as molecular switches to regulate vesicle trafficking pathways. The different Rab GTPases are localized to the cytosolic face of specific intracellular membranes, where they regulate distinct steps in membrane traffic pathways. In the GTP-bound form, Rab GTPases recruit specific sets of effector proteins onto membranes. Through their effectors, Rab GTPases regulate vesicle formation, actin- and tubulin-dependent vesicle movement, and membrane fusion. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide di Probab=98.90 E-value=1.2e-07 Score=73.87 Aligned_columns=152 Identities=28% Q ss_pred EEEEECCCCCHHHHHHHHHC---CCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEE Q ss_conf 88860788548999998620---133678743103353021213473001005885676021135322477343302102 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTKLQG---AEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLV 133 (492) Q Consensus 57 ILvLG~~~sGKttLi~~Lq~---~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlV 133 (492) |+++|+.++|||+|+.++.. .+.....-|.+|....+. ..+...++.+|=..|.-.+..+.+..+.--+ .+ T Consensus 3 i~ivG~~~vGKTsli~~~~~~~f~~~~~~Ti~~~~~~k~i~--~~~~~~~~~i~Dt~g~e~~~~~~~~~~~~~d----~~ 76 (159) T cd00154 3 IVLIGDSGVGKTSLLLRFVDGKFDENYKSTIGVDFKSKTIE--IDGKTVKLQIWDTAGQERFRSITPSYYRGAH----GA 76 (159) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEE--ECCEEEEEEEEECCCCHHHHHHHHHHCCCCC----EE T ss_conf 89982699668999999863824744465310036888998--8895999999865997145677787514898----69 Q ss_pred EEHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCC Q ss_conf 00021203247999999999999999972488889999999999999862035000577776766454566540000368 Q Ver_Hs_NP_0061 134 IFVADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALP 213 (492) Q Consensus 134 vI~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lP 213 (492) +||.|++.+.++ +.++.|++.+++... T Consensus 77 iiv~d~~~~~Sf-~~i~~~~~~i~~~~~---------------------------------------------------- 103 (159) T cd00154 77 ILVYDITNRESF-ENLDKWLKELKEYAP---------------------------------------------------- 103 (159) T ss_pred EEEEECCCHHHH-HHHHHHHHHHHHHCC---------------------------------------------------- T ss_conf 999866997899-999999999998269---------------------------------------------------- Q ss_pred CCCCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHH Q ss_conf 88762214799407998507522555542057747789999999999998708737884566635679999999 Q Ver_Hs_NP_0061 214 LGDNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYI 287 (492) Q Consensus 214 Lgeg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi 287 (492) -.+|+++|++|+|. .++-.+.....|.+|-++++..+.||++...|++-+.+-| T Consensus 104 ---------~~~piiivgnK~Dl-----------~~~~~v~~~~~~~~~~~~~~~~~e~Sa~~~~~i~~~F~~i 157 (159) T cd00154 104 ---------ENIPIILVGNKIDL-----------EDQRQVSTEEAQQFAKENGLLFFETSAKTGENVEELFQSL 157 (159) T ss_pred ---------CCCEEEEEECCCCH-----------HHHCCCCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHH T ss_conf ---------99789998413100-----------0102656889999999659969999704798878999997 No 26 >1xtq_A GTP-binding protein RHEB; beta saddle, P-loop; HET: GDP; 2.00A {Homo sapiens} SCOP: c.37.1.8 Probab=98.90 E-value=7.4e-07 Score=68.55 Aligned_columns=157 Identities=20% Q ss_pred EEEEECCCCCHHHHHHHHHC---CCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEE Q ss_conf 88860788548999998620---133678743103353021213473001005885676021135322477343302102 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTKLQG---AEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLV 133 (492) Q Consensus 57 ILvLG~~~sGKttLi~~Lq~---~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlV 133 (492) |+|+|..++|||||+.++.+ .+......+..|...-..+ +...++.+|-..|...+..+.+..+.. --.+ T Consensus 9 i~iiG~~~vGKSsLi~~~~~~~~~~~~~~t~~~~~~~~~~~~---~~~~~l~i~D~~g~~~~~~~~~~~~~~----~d~~ 81 (177) T 1xtq_A 9 IAILGYRSVGKSSLTIQFVEGQFVDSYDPTIENTFTKLITVN---GQEYHLQLVDTAGQDEYSIFPQTYSID----INGY 81 (177) T ss_dssp EEEEESTTSSHHHHHHHHHHSCCCSCCCSSCCEEEEEEEEET---TEEEEEEEEECCCCCTTCCCCGGGTSS----CCEE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEECCC---CEEEEEEEEECCCCCCCCCCCCCCCHH----HHHH T ss_conf 899807998789999998627236664312320011210135---445664210011000112223321000----3332 Q ss_pred EEHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCC Q ss_conf 00021203247999999999999999972488889999999999999862035000577776766454566540000368 Q Ver_Hs_NP_0061 134 IFVADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALP 213 (492) Q Consensus 134 vI~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lP 213 (492) +||.|.+.|.++ +.++.|+.-+.++..+ T Consensus 82 i~v~d~~~~~s~-~~~~~~~~~i~~~~~~--------------------------------------------------- 109 (177) T 1xtq_A 82 ILVYSVTSIKSF-EVIKVIHGKLLDMVGK--------------------------------------------------- 109 (177) T ss_dssp EEEEETTCHHHH-HHHHHHHHHHHHHHCS--------------------------------------------------- T ss_pred HHHHCCCCCCCC-CHHCCHHHHHHHHCCC--------------------------------------------------- T ss_conf 110001112320-0001001221110035--------------------------------------------------- Q ss_pred CCCCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHH Q ss_conf 8876221479940799850752255554205774778999999999999870873788456663567999999988872 Q Ver_Hs_NP_0061 214 LGDNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTY 292 (492) Q Consensus 214 Lgeg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~Hrly 292 (492) ..+|+++|++|+| |..+.....++. +.||-++|...|.||++...|++-+...|+..+. T Consensus 110 ---------~~~piiivgnK~D----l~~~~~v~~~~~-------~~~~~~~~~~~~e~Sa~~g~gi~elf~~ii~~i~ 168 (177) T 1xtq_A 110 ---------VQIPIMLVGNKKD----LHMERVISYEEG-------KALAESWNAAFLESSAKENQTAVDVFRRIILEAE 168 (177) T ss_dssp ---------SCCCEEEEEECTT----CGGGCCSCHHHH-------HHHHHHHTCEEEECCTTCHHHHHHHHHHHHHHHH T ss_pred ---------CCCCEEEEEECCC----CHHHCCCCHHHH-------HHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHH T ss_conf ---------7862699961257----300015788899-------9999964982899861689788899999999999 No 27 >e1x3sa1 c.37.1.8 (A:2-178) Rab18 {Human (Homo sapiens) [TaxID:9606]} Probab=98.90 E-value=1.9e-07 Score=72.46 Aligned_columns=169 Identities=25% Q ss_pred CCCCCCEEEEEECCCCCHHHHHHHHHCCC-CCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCH Q ss_conf 27887648886078854899999862013-36787431033530212134730010058856760211353224773433 Q Ver_Hs_NP_0061 50 KLPSGKNILVFGEDGSGKTTLMTKLQGAE-HGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESL 128 (492) Q Consensus 50 klp~~KnILvLG~~~sGKttLi~~Lq~~e-~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si 128 (492) .+|+ =.|+|+|+.++|||||+.+|.+.+ ...-...++-.|....-...+..-++.+|-..|...+..+.+..+.. T Consensus 4 ~~~~-iKi~ivG~~~vGKTtLi~~~~~~~~~~~~~~t~~~~~~~~~~~~~~~~~~~~l~d~~~~~~~~~~~~~~~~~--- 79 (177) T e1x3sa1 4 VLTT-LKILIIGESGVGKSSLLLRFTDDTFDPELAATIGVDFKVKTISVDGNKAKLAIWDTAGQERFRTLTPSYYRG--- 79 (177) T ss_pred CCCE-EEEEEECCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEEECCEEEEEEEECCCCCHHHHHHHHHHCCC--- T ss_conf 6661-358998079987999999986481167514641013567899887948999971165310222330433157--- Q ss_pred HHEEEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCH Q ss_conf 02102000212032479999999999999999724888899999999999998620350005777767664545665400 Q Ver_Hs_NP_0061 129 PETLVIFVADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEE 208 (492) Q Consensus 129 ~~TlVvI~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~ 208 (492) -..+++|.|.+.+..+-+ +..|+.-++ T Consensus 80 -~d~~i~~~d~~~~~s~~~-~~~~~~~i~--------------------------------------------------- 106 (177) T e1x3sa1 80 -AQGVILVYDVTRRDTFVK-LDNWLNELE--------------------------------------------------- 106 (177) T ss_pred -CCEEEEECCCCCCHHHHH-HHHHHHHHH--------------------------------------------------- T ss_conf -606898504676101000-135899999--------------------------------------------------- Q ss_pred HCCCCCCCCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHH Q ss_conf 00368887622147994079985075225555420577477899999999999987087378845666356799999998 Q Ver_Hs_NP_0061 209 NVALPLGDNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIV 288 (492) Q Consensus 209 ~v~lPLgeg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~ 288 (492) ....+..+|++||++|+| |.++.-..+| ++.||-++|+..+.||++...|++-+.+.++ T Consensus 107 ---------~~~~~~~~~iiiv~nK~D----l~~~~v~~~e--------~~~~~~~~~~~~~e~Sa~~g~gi~e~f~~i~ 165 (177) T e1x3sa1 107 ---------TYCTRNDIVNMLVGNKID----KENREVDRNE--------GLKFARKHSMLFIEASAKTCDGVQCAFEELV 165 (177) T ss_pred ---------HHCCCCCCCEEEECCCCH----HHCCCCCHHH--------HHHHHHHCCCEEEEEECCCCCCHHHHHHHHH T ss_conf ---------745766632245301100----1104678889--------9999996598299986168878789999999 Q ss_pred HHHHCCCC Q ss_conf 88727776 Q Ver_Hs_NP_0061 289 HKTYGFHF 296 (492) Q Consensus 289 Hrlygfpf 296 (492) +.++.-|+ T Consensus 166 ~~i~~~~~ 173 (177) T e1x3sa1 166 EKIIQTPG 173 (177) T ss_pred HHHHCCCC T ss_conf 99850777 No 28 >1x1r_A RAS-related protein M-RAS; GTP-binding; HET: GDP; 1.30A {Mus musculus} SCOP: c.37.1.8 Probab=98.89 E-value=4.6e-07 Score=69.93 Aligned_columns=157 Identities=20% Q ss_pred EEEEECCCCCHHHHHHHHHC---CCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEE Q ss_conf 88860788548999998620---133678743103353021213473001005885676021135322477343302102 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTKLQG---AEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLV 133 (492) Q Consensus 57 ILvLG~~~sGKttLi~~Lq~---~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlV 133 (492) |+|+|+.++|||||+.+|.+ .+.....-|-.|...-..+ +....+.+|-..|.-.+..+.+..+. .-..+ T Consensus 16 i~iiG~~~vGKTsll~~l~~~~~~~~~~~t~~~~~~~~~~~~---~~~~~~~i~d~~g~e~~~~~~~~~~~----~~~~~ 88 (178) T 1x1r_A 16 LVVVGDGGVGKSALTIQFFQKIFVPDYDPTIEDSYLKHTEID---NQWAILDVLDTAGQEEFSAMREQYMR----TGDGF 88 (178) T ss_dssp EEEECCTTSSHHHHHHHHHHSSCCTTCCTTCCEEEEEEEEET---TEEEEEEEEECCSCGGGCSSHHHHHH----HCSEE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEECCCCCCCCCC---CCEEEEEEEEECCCCCCCCCCHHHCC----CCCEE T ss_conf 998817997789999998628237754541100112001237---81478877751365323325400104----78547 Q ss_pred EEHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCC Q ss_conf 00021203247999999999999999972488889999999999999862035000577776766454566540000368 Q Ver_Hs_NP_0061 134 IFVADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALP 213 (492) Q Consensus 134 vI~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lP 213 (492) ++|.|++.+..+ ..+..|...+..+. T Consensus 89 i~vfd~~~~~S~-~~~~~~~~~~~~~~----------------------------------------------------- 114 (178) T 1x1r_A 89 LIVYSVTDKASF-EHVDRFHQLILRVK----------------------------------------------------- 114 (178) T ss_dssp EEEEETTCHHHH-HTHHHHHHHHHHHH----------------------------------------------------- T ss_pred EEEEECCCCCCH-HHHHHHHHHHHHHC----------------------------------------------------- T ss_conf 999742454211-24456666665302----------------------------------------------------- Q ss_pred CCCCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCC-CHHHHHHHHHHHHH Q ss_conf 88762214799407998507522555542057747789999999999998708737884566635-67999999988872 Q Ver_Hs_NP_0061 214 LGDNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEK-NLDLLYKYIVHKTY 292 (492) Q Consensus 214 Lgeg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~k-Nl~lLykYi~Hrly 292 (492) .+-++|+++|++|+|..+ +..-..++. +.||-+||...+.||+|... |++-+.+.|++.++ T Consensus 115 -------~~~~~piiiVgnK~D~~~----~~~v~~~e~-------~~~~~~~~~~~~e~Sak~~~~~i~e~f~~i~~~i~ 176 (178) T 1x1r_A 115 -------DRESFPMILVANKVDLMH----LRKVTRDQG-------KEMATKYNIPYIETSAKDPPLNVDKTFHDLVRVIR 176 (178) T ss_dssp -------TSSCCCEEEEEECTTCST----TCCSCHHHH-------HHHHHHHTCCEEEEBCSSSCBSHHHHHHHHHHHHH T ss_pred -------CCCCCEEEEEEECCCCCC----CCCCCHHHH-------HHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHH T ss_conf -------567640467752455210----035588999-------99999659948999615488787899999999998 No 29 >2j1l_A RHO-related GTP-binding protein RHOD; GTPase, membrane, prenylation, hydrolase, nucleotide-binding, methylation, lipoprotein, endosome dynamics; HET: GDP; 2.5A {Homo sapiens} Probab=98.89 E-value=4.5e-08 Score=76.66 Aligned_columns=170 Identities=18% Q ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEEEEH Q ss_conf 88860788548999998620133678743103353021213473001005885676021135322477343302102000 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTKLQGAEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLVIFV 136 (492) Q Consensus 57 ILvLG~~~sGKttLi~~Lq~~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlVvI~ 136 (492) |+|+|+.++||||||.+|...+....-....-......=.-.+..-++.+|-..|...+..+.+..+..-. .|++| T Consensus 37 I~iiG~~gvGKSSLi~~l~~~~~~~~~~~t~~~~~~~~~~~~~~~~~~~iwD~~g~~~~~~~~~~~~~~~~----~iilV 112 (214) T 2j1l_A 37 VVLVGDGGCGKTSLLMVFADGAFPESYTPTVFERYMVNLQVKGKPVHLHIWDTAGQDDYDRLRPLFYPDAS----VLLLC 112 (214) T ss_dssp EEEEECTTSSHHHHHHHHHC-------CCCCCEEEEEEEEETTEEEEEEEEEC---------------CEE----EEEEE T ss_pred EEEECCCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEECCEEEEEECCCCCCHHHHHHHHHHHCCCCE----EEEEE T ss_conf 99870799779999999863733676465013578999864684787410356501121001022204404----56653 Q ss_pred HHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCCCCC Q ss_conf 21203247999999999999999972488889999999999999862035000577776766454566540000368887 Q Ver_Hs_NP_0061 137 ADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLGD 216 (492) Q Consensus 137 lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lPLge 216 (492) .|++.|+++-.-.+.|...++.... T Consensus 113 ~d~~~~~s~~~~~~~~~~~~~~~~~------------------------------------------------------- 137 (214) T 2j1l_A 113 FDVTSPNSFDNIFNRWYPEVNHFCK------------------------------------------------------- 137 (214) T ss_dssp EETTCHHHHHHHHHTHHHHHHHHCS------------------------------------------------------- T ss_pred ECCCCHHHHHHHHHHHHHHHHHHCC------------------------------------------------------- T ss_conf 1133003344444678999986248------------------------------------------------------- Q ss_pred CCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHH-HHHHHHHHHHCCCEEEE-ECCCCCCCHHHHHHHHHHHHH Q ss_conf 62214799407998507522555542057747789999-99999999870873788-456663567999999988872 Q Ver_Hs_NP_0061 217 NVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFI-QSHLRRFCLQYGAALIY-TSVKEEKNLDLLYKYIVHKTY 292 (492) Q Consensus 217 g~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~I-qq~LR~~cL~YGAsLiY-TS~ke~kNl~lLykYi~Hrly 292 (492) .+|+++|++|+|..+.-+....+.......| ....+.+|-+++.--+| ||++...|++-+...|+..++ T Consensus 138 -------~~piilvgnK~Dl~~~~~~~~~~~~~~~~~i~~~~~~~~a~~~~~~~~~E~Sakt~~gV~~~f~~ii~~~l 208 (214) T 2j1l_A 138 -------KVPIIVVGCKTDLRKDKSLVNKLRRNGLEPVTYHRGQEMARSVGAVAYLECSARLHDNVHAVFQEAAEVAL 208 (214) T ss_dssp -------SCCEEEEEECGGGGSCHHHHHHHHHTTCCCCCHHHHHHHHHHTTCSEEEECBTTTTBSHHHHHHHHHHHHH T ss_pred -------CCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHH T ss_conf -------86354211356631124566677763047673789999999708931788740588678899999999999 No 30 >d1r2qa_ c.37.1.8 (A:) Rab5a {Human (Homo sapiens)} SCOP: d1n6oa_ d1tu4a_ d1n6la_ d1tu4d_ d1n6ka_ d1n6ha_ d1tu3c_ d1tu3b_ d1n6na_ d1n6ra_ d1tu4b_ d1n6pa_ d1tu3d_ u1z0da1 d1huqa_ u1z07a1 Probab=98.89 E-value=1.8e-07 Score=72.66 Aligned_columns=159 Identities=18% Q ss_pred EEEEECCCCCHHHHHHHHHCCC-CCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEEEE Q ss_conf 8886078854899999862013-367874310335302121347300100588567602113532247734330210200 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTKLQGAE-HGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLVIF 135 (492) Q Consensus 57 ILvLG~~~sGKttLi~~Lq~~e-~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlVvI 135 (492) |+|+|+.++|||||+.++.+.+ .........-.|..+.....+...++.+|-..|...+..+.+..+..- ..+++ T Consensus 9 i~ivG~~~vGKTsli~~~~~~~~~~~~~~t~~~~~~~~~~~~~~~~~~~~i~D~~g~~~~~~~~~~~~~~~----~~~i~ 84 (170) T d1r2qa_ 9 LVLLGESAVGKSSLVLRFVKGQFHEFQESTIGAAFLTQTVCLDDTTVKFEIWDTAGQERYHSLAPMYYRGA----QAAIV 84 (170) T ss_dssp EEEECSTTSSHHHHHHHHHHSCCCTTCCCCSSEEEEEEEEEETTEEEEEEEEEECCSGGGGGGHHHHHTTC----SEEEE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEEECCEEEEEEEECCCCCHHHHHHHHHHCCCC----CEEEE T ss_conf 99982799779999999864812556353035677776565569079998742777303445412102688----67999 Q ss_pred HHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCCCC Q ss_conf 02120324799999999999999997248888999999999999986203500057777676645456654000036888 Q Ver_Hs_NP_0061 136 VADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLG 215 (492) Q Consensus 136 ~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lPLg 215 (492) |.|.+.+..+-..-+.|....+ T Consensus 85 v~d~~~~~s~~~~~~~~~~~~~---------------------------------------------------------- 106 (170) T d1r2qa_ 85 VYDITNEESFARAKNWVKELQR---------------------------------------------------------- 106 (170) T ss_dssp EEETTCHHHHHHHHHHHHHHHH---------------------------------------------------------- T ss_pred EEECCCHHHHHHHHHHHHHHHH---------------------------------------------------------- T ss_conf 8306520358889888999988---------------------------------------------------------- Q ss_pred CCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHH Q ss_conf 76221479940799850752255554205774778999999999999870873788456663567999999988872 Q Ver_Hs_NP_0061 216 DNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTY 292 (492) Q Consensus 216 eg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~Hrly 292 (492) .....+|+++|.+|+|. .++..+.++.++.|+-.+++.++.||++...+++-+...|.++++ T Consensus 107 ----~~~~~~piilv~nK~Dl-----------~~~~~i~~~~~~~~~~~~~~~~~e~Sak~g~gi~elf~~i~~~l~ 168 (170) T d1r2qa_ 107 ----QASPNIVIALSGNKADL-----------ANKRAVDFQEAQSYADDNSLLFMETSAKTSMNVNEIFMAIAKKLP 168 (170) T ss_dssp ----HSCTTCEEEEEEECGGG-----------GGGCCSCHHHHHHHHHHTTCEEEECCTTTCTTHHHHHHHHHHTSC T ss_pred ----HHHCCCCEEEEECCHHH-----------HHHCCCCHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHC T ss_conf ----64058612443032110-----------100365878999999855983999861689788899999999841 No 31 >d1r2qa_ c.37.1.8 (A:) Rab5a {Human (Homo sapiens)} Probab=98.88 E-value=1.5e-07 Score=73.14 Aligned_columns=160 Identities=20% Q ss_pred EEEEEECCCCCHHHHHHHHHCCC-CCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEEE Q ss_conf 48886078854899999862013-36787431033530212134730010058856760211353224773433021020 Q Ver_Hs_NP_0061 56 NILVFGEDGSGKTTLMTKLQGAE-HGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLVI 134 (492) Q Consensus 56 nILvLG~~~sGKttLi~~Lq~~e-~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlVv 134 (492) .|+++|..++|||||+.+|.+.+ .......+.-.|..+.-...+...++.+|-..|.-.+..+.+..+..- ..++ T Consensus 8 ki~liG~~~vGKSsli~~~~~~~~~~~~~~t~~~~~~~~~~~~~~~~~~~~i~d~~g~~~~~~~~~~~~~~~----~~~i 83 (170) T d1r2qa_ 8 KLVLLGESAVGKSSLVLRFVKGQFHEFQESTIGAAFLTQTVCLDDTTVKFEIWDTAGQERYHSLAPMYYRGA----QAAI 83 (170) T ss_dssp EEEEECSTTSSHHHHHHHHHHSCCCTTCCCCSSEEEEEEEEEETTEEEEEEEEEECCSGGGGGGHHHHHTTC----SEEE T ss_pred EEEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEECCEEEEEEEECCCCCCHHHHHHHHHHCCC----CEEE T ss_conf 899981799879999999864801566244202454345455579179998730677301123215540465----2899 Q ss_pred EHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCCC Q ss_conf 00212032479999999999999999724888899999999999998620350005777767664545665400003688 Q Ver_Hs_NP_0061 135 FVADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPL 214 (492) Q Consensus 135 I~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lPL 214 (492) +|.|.+++..+ +.+..|+.-++..... T Consensus 84 ~v~d~~~~~s~-~~~~~~~~~~~~~~~~---------------------------------------------------- 110 (170) T d1r2qa_ 84 VVYDITNEESF-ARAKNWVKELQRQASP---------------------------------------------------- 110 (170) T ss_dssp EEEETTCHHHH-HHHHHHHHHHHHHSCT---------------------------------------------------- T ss_pred EEEECCCHHHH-HHHHHHHHHHHHHCCC---------------------------------------------------- T ss_conf 99625301468-9999999998750378---------------------------------------------------- Q ss_pred CCCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHH Q ss_conf 876221479940799850752255554205774778999999999999870873788456663567999999988872 Q Ver_Hs_NP_0061 215 GDNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTY 292 (492) Q Consensus 215 geg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~Hrly 292 (492) .+|+++|.+|+|. .++-.+-+..++.|+-.+++..+.||++...|++-+..+|.++++ T Consensus 111 ---------~~piilVgnK~Dl-----------~~~~~v~~~~~~~~~~~~~~~~~e~Sa~~~~gi~elf~~l~~~i~ 168 (170) T d1r2qa_ 111 ---------NIVIALSGNKADL-----------ANKRAVDFQEAQSYADDNSLLFMETSAKTSMNVNEIFMAIAKKLP 168 (170) T ss_dssp ---------TCEEEEEEECGGG-----------GGGCCSCHHHHHHHHHHTTCEEEECCTTTCTTHHHHHHHHHHTSC T ss_pred ---------CEEEEEEEEHHHH-----------HHHCCCCHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHC T ss_conf ---------5577753200102-----------210477989999999955981899862689788899999999832 No 32 >2fn4_A P23, RAS-related protein R-RAS; GDP/GTP binding, GTP hydrolysis, structural genomics, structural genomics consortium, SGC; HET: GDP; 1.65A {Homo sapiens} SCOP: c.37.1.8 Probab=98.88 E-value=4.8e-07 Score=69.78 Aligned_columns=160 Identities=18% Q ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEEEEH Q ss_conf 88860788548999998620133678743103353021213473001005885676021135322477343302102000 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTKLQGAEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLVIFV 136 (492) Q Consensus 57 ILvLG~~~sGKttLi~~Lq~~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlVvI~ 136 (492) |+|+|+.++|||||+.+|.+.+-...-.......+...=......-++.+|-..|.-.+..+.+.....-. .+++| T Consensus 12 I~viG~~~vGKTsLi~~l~~~~~~~~~~~t~~~~~~~~~~~~~~~i~~~i~d~~~~~~~~~~~~~~~~~~~----~~i~v 87 (181) T 2fn4_A 12 LVVVGGGGVGKSALTIQFIQSYFVSDYDPTIEDSYTKICSVDGIPARLDILDTAGQEEFGAMREQYMRAGH----GFLLV 87 (181) T ss_dssp EEEEECTTSSHHHHHHHHHHSSCCSSCCTTCCEEEEEEEEETTEEEEEEEEECCCTTTTSCCHHHHHHHCS----EEEEE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEECCCCEEEEEEEECCCCCHHHHHHHHHHHCCHH----HEEEE T ss_conf 99980799879999999863823676354157766555336882799886024572011000122200001----02331 Q ss_pred HHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCCCCC Q ss_conf 21203247999999999999999972488889999999999999862035000577776766454566540000368887 Q Ver_Hs_NP_0061 137 ADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLGD 216 (492) Q Consensus 137 lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lPLge 216 (492) .|.+.+ .-.+.+.+|+..+. T Consensus 88 ~d~~~~-~s~~~~~~~~~~~~----------------------------------------------------------- 107 (181) T 2fn4_A 88 FAINDR-QSFNEVGKLFTQIL----------------------------------------------------------- 107 (181) T ss_dssp EETTCH-HHHHHHHHHHHHHH----------------------------------------------------------- T ss_pred EEECCC-CHHHHHHHHHHHHH----------------------------------------------------------- T ss_conf 000121-00234432232222----------------------------------------------------------- Q ss_pred CCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHH Q ss_conf 6221479940799850752255554205774778999999999999870873788456663567999999988872 Q Ver_Hs_NP_0061 217 NVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTY 292 (492) Q Consensus 217 g~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~Hrly 292 (492) ......++|+++|++|+| |+.+.....++ ++.++.+++...+.||++...|++-+...|.+.++ T Consensus 108 -~~~~~~~~piilvgnK~D----l~~~~~~~~~~-------~~~~~~~~~~~~~e~Sak~~~~v~~~f~~l~~~i~ 171 (181) T 2fn4_A 108 -RVKDRDDFPVVLVGNKAD----LESQRQVPRSE-------ASAFGASHHVAYFEASAKLRLNVDEAFEQLVRAVR 171 (181) T ss_dssp -HHHTSSCCCEEEEEECGG----GGGGCCSCHHH-------HHHHHHHTTCEEEECBTTTTBSHHHHHHHHHHHHH T ss_pred -HHCCCCCCEEEEEECCCC----CHHHHHHHHHH-------HHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHH T ss_conf -110157850799706655----10233104788-------88999870872799960589888899999999999 No 33 >d1oiva_ c.37.1.8 (A:) Rab11a {Human (Homo sapiens)} Probab=98.88 E-value=2.7e-07 Score=71.43 Aligned_columns=159 Identities=21% Q ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCC-CCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEEEE Q ss_conf 8886078854899999862013367874-310335302121347300100588567602113532247734330210200 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTKLQGAEHGKKGR-GLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLVIF 135 (492) Q Consensus 57 ILvLG~~~sGKttLi~~Lq~~e~~kkg~-gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlVvI 135 (492) |+|+|+.++|||||+.+|.+.+-..... ..+..+....-...+..-++.+|-..|...+..+-+..+..-.. ++| T Consensus 9 i~ivG~~~vGKSSLi~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~i~D~~g~~~~~~~~~~~~~~~d~----~i~ 84 (168) T d1oiva_ 9 VVLIGDSGVGKSNLLSRFTRNEFNLESKSTIGVEFATRSIQVDGKTIKAQIWDTAGQERYRAITSAYYRGAVG----ALL 84 (168) T ss_dssp EEEESSTTSSHHHHHHHHHHSCCCSSCCCCSSEEEEEEEEEETTEEEEEEEEEECSCCCCHHHHHHHHTTEEE----EEE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEEECCEEEEEEEECCCCCCHHHHHHHHHHCCCCE----EEE T ss_conf 9998369987999999986580343655326533422789988948999985067830123555776227878----999 Q ss_pred HHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCCCC Q ss_conf 02120324799999999999999997248888999999999999986203500057777676645456654000036888 Q Ver_Hs_NP_0061 136 VADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLG 215 (492) Q Consensus 136 ~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lPLg 215 (492) |.|.+.+ .-++.+.+|+.-++...... T Consensus 85 v~d~~~~-~s~~~i~~~~~~i~~~~~~~---------------------------------------------------- 111 (168) T d1oiva_ 85 VYDIAKH-LTYENVERWLKELRDHADSN---------------------------------------------------- 111 (168) T ss_dssp EEETTCH-HHHHTHHHHHHHHHHHSCTT---------------------------------------------------- T ss_pred EEEECCC-CHHHHHHHHHHHHHHHCCCC---------------------------------------------------- T ss_conf 9984263-01688999999998614895---------------------------------------------------- Q ss_pred CCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHH Q ss_conf 76221479940799850752255554205774778999999999999870873788456663567999999988872 Q Ver_Hs_NP_0061 216 DNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTY 292 (492) Q Consensus 216 eg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~Hrly 292 (492) +|++||++|+| |+++..-..|+ .|.||-++|+..+-||+|...|++-+.+.|+-++| T Consensus 112 ---------~piiivgnK~D----l~~~~~v~~~~-------~~~~~~~~~~~~~e~Sak~g~~i~e~f~~ii~~i~ 168 (168) T d1oiva_ 112 ---------IVIMLVGNKSD----LRHLRAVPTDE-------ARAFAEKNGLSFIETSALDSTNVEAAFQTILTEIY 168 (168) T ss_dssp ---------CEEEEEEECTT----CGGGCCSCHHH-------HHHHHHHHTCEEEECCTTTCTTHHHHHHHHHHHHC T ss_pred ---------EEEEEEEECCC----HHHCCCCCHHH-------HHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHC T ss_conf ---------38996110001----22203779899-------99999963993899971689787899999999709 No 34 >cd00877 Ran Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases. Ran GTPase is involved in diverse biological functions, such as nuclear transport, spindle formation during mitosis, DNA replication, and cell division. Among the Ras superfamily, Ran is a unique small G protein. It does not have a lipid modification motif at the C-terminus to bind to the membrane, which is often observed within the Ras superfamily. Ran may therefore interact with a wide range of proteins in various intracellular locations. Like other GTPases, Ran exists in GTP- and GDP-bound conformations that interact differently with effectors. Conversion between these forms and the assembly or disassembly of effector complexes requires the interaction of regulator proteins. The intrinsic GTPase activity of Ran is very low, but it is greatly stimulated by a GTPase-activating protein (RanGAP1) located in the cytoplasm. By contrast, RCC1, a guanine nucleotide exchange factor that generates RanGTP, is Probab=98.88 E-value=3e-07 Score=71.15 Aligned_columns=157 Identities=22% Q ss_pred EEEEECCCCCHHHHHHHHHC---CCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEE Q ss_conf 88860788548999998620---133678743103353021213473001005885676021135322477343302102 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTKLQG---AEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLV 133 (492) Q Consensus 57 ILvLG~~~sGKttLi~~Lq~---~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlV 133 (492) |+++|+.++|||+|+.++.. .+.+...-|.++....+....+ ..++.+|=..|...+.+|......- --.+ T Consensus 3 IvliGd~~VGKTsli~r~~~~~F~~~y~~Tig~~~~~~~~~~~~~--~i~l~iwDtaG~e~f~~l~~~y~~~----a~~~ 76 (166) T cd00877 3 LVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLDFHTNRG--KIRFNVWDTAGQEKFGGLRDGYYIG----GQCA 76 (166) T ss_pred EEEEECCCCCHHHHHHHHHCCEECCCCCCEEEEEEEEEEEEECCC--EEEEEEEECCCCCCCCCCCCCCCCC----CCEE T ss_conf 899826984489998887638116664534644888999998794--7999988457852135455120002----6758 Q ss_pred EEHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCC Q ss_conf 00021203247999999999999999972488889999999999999862035000577776766454566540000368 Q Ver_Hs_NP_0061 134 IFVADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALP 213 (492) Q Consensus 134 vI~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lP 213 (492) |||-|.+.++++-. +..|++-++.+...+ T Consensus 77 ilvfDit~~~Sf~~-i~~w~~~i~~~~~~i-------------------------------------------------- 105 (166) T cd00877 77 IIMFDVTSRVTYKN-VPNWHRDLVRVCGNI-------------------------------------------------- 105 (166) T ss_pred EEEEECCCHHHHHH-HHHHHHHHHHHCCCC-------------------------------------------------- T ss_conf 99986699789898-988999998645996-------------------------------------------------- Q ss_pred CCCCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHC Q ss_conf 88762214799407998507522555542057747789999999999998708737884566635679999999888727 Q Ver_Hs_NP_0061 214 LGDNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTYG 293 (492) Q Consensus 214 Lgeg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~Hrlyg 293 (492) |+++|.+|+| |+.+....++. .++-++++..|-||+|...|++-+.++|.-++++ T Consensus 106 ------------pivlVGNK~D----l~~~~~~~~~~---------~~~~~~~~~~~EtSAk~g~NV~e~F~~la~~il~ 160 (166) T cd00877 106 ------------PIVLCGNKVD----IKDRKVKAKQI---------TFHRKKNLQYYEISAKSNYNFEKPFLWLARKLLG 160 (166) T ss_pred ------------CEEEEECCCC----CCCCCCCHHHH---------HHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHC T ss_conf ------------5899932677----32011248999---------9999579949999704898988999999999853 Q ss_pred CC Q ss_conf 77 Q Ver_Hs_NP_0061 294 FH 295 (492) Q Consensus 294 fp 295 (492) -| T Consensus 161 ~~ 162 (166) T cd00877 161 NP 162 (166) T ss_pred CC T ss_conf 78 No 35 >cd04101 RabL4 RabL4 (Rab-like4) subfamily. RabL4s are novel proteins that have high sequence similarity with Rab family members, but display features that are distinct from Rabs, and have been termed Rab-like. As in other Rab-like proteins, RabL4 lacks a prenylation site at the C-terminus. The specific function of RabL4 remains unknown. Probab=98.88 E-value=2.4e-07 Score=71.79 Aligned_columns=157 Identities=18% Q ss_pred EEEEECCCCCHHHHHHHHHCC-----CCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHE Q ss_conf 888607885489999986201-----336787431033530212134730010058856760211353224773433021 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTKLQGA-----EHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPET 131 (492) Q Consensus 57 ILvLG~~~sGKttLi~~Lq~~-----e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~T 131 (492) |+++|+.++|||+|+.++-.. +.....-|.+|....+.=.+ ++...+.+|=..|...+..+.+....--+. T Consensus 3 vv~iGd~~VGKTsli~~~~~~~~~f~~~y~~T~~~~~~~~~~~i~~-~~~~~l~i~DtaGqe~~~~~~~~~~~~a~~--- 78 (164) T cd04101 3 CAVVGDPAVGKTAFVQMFHSNGAVFPKNYLMTTGCDFVVKEVPVDT-DNTVELFIFDSAGQELYSDMVSNYWESPSV--- 78 (164) T ss_pred EEEEECCCCCHHHHHHHHHHCCCEECCCCCCCEEEEEEEEEEEECC-CCEEEEEEEECCCCHHHHHHHHHHCCCCCE--- T ss_conf 8998079821898888776168441666543112456799999779-967999996038722467887874249976--- Q ss_pred EEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCC Q ss_conf 02000212032479999999999999999724888899999999999998620350005777767664545665400003 Q Ver_Hs_NP_0061 132 LVIFVADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVA 211 (492) Q Consensus 132 lVvI~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~ 211 (492) ++||-|.+.+..+ +++.+|+.-++.+-.. T Consensus 79 -~ilvydit~~~Sf-~~i~~w~~~i~~~~~~------------------------------------------------- 107 (164) T cd04101 79 -FILVYDVSNKASF-ENCSRWVNKVRTASKH------------------------------------------------- 107 (164) T ss_pred -EEEEEECCCHHHH-HHHHHHHHHHHHHCCC------------------------------------------------- T ss_conf -9999417997689-9999999999984499------------------------------------------------- Q ss_pred CCCCCCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHH Q ss_conf 68887622147994079985075225555420577477899999999999987087378845666356799999998887 Q Ver_Hs_NP_0061 212 LPLGDNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKT 291 (492) Q Consensus 212 lPLgeg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~Hrl 291 (492) +|+++|.+|+| |+..+.-.+|+ .|.+|-.+++..|.||+|...|++-++..|.-.. T Consensus 108 -------------~p~ilVGNK~D----L~~~r~V~~~~-------~~~~a~~~~~~~~e~SAktg~nV~e~F~~lar~~ 163 (164) T cd04101 108 -------------MPGVLVGNKMD----LADKAEVTDAQ-------AQAFAQANQLKFFKTSALRGVGYEEPFESLARAF 163 (164) T ss_pred -------------CEEEEEECCCC----CCCCCCCCHHH-------HHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHH T ss_conf -------------73999821434----00116789899-------9999996399499997168988789999999972 Q ss_pred H Q ss_conf 2 Q Ver_Hs_NP_0061 292 Y 292 (492) Q Consensus 292 y 292 (492) . T Consensus 164 ~ 164 (164) T cd04101 164 H 164 (164) T ss_pred C T ss_conf 9 No 36 >1r2q_A RAS-related protein RAB-5A; GTPase, GNP, atomic resolution; HET: GNP; 1.05A {Homo sapiens} SCOP: c.37.1.8 Probab=98.88 E-value=5.4e-07 Score=69.45 Aligned_columns=158 Identities=20% Q ss_pred EEEEECCCCCHHHHHHHHHCCC-CCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEEEE Q ss_conf 8886078854899999862013-367874310335302121347300100588567602113532247734330210200 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTKLQGAE-HGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLVIF 135 (492) Q Consensus 57 ILvLG~~~sGKttLi~~Lq~~e-~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlVvI 135 (492) |+|+|+.++|||+|+.+|.+.+ ....-..++..+....-...+...++.+|-..|.-.+..+.+..+.. -..|++ T Consensus 9 v~viG~~~vGKTsLi~~~~~~~~~~~~~~t~~~~~~~~~~~~~~~~~~l~i~d~~g~~~~~~~~~~~~~~----~~~~i~ 84 (170) T 1r2q_A 9 LVLLGESAVGKSSLVLRFVKGQFHEFQESTIGAAFLTQTVCLDDTTVKFEIWDTAGQERYHSLAPMYYRG----AQAAIV 84 (170) T ss_dssp EEEECSTTSSHHHHHHHHHHSCCCTTCCCCSSEEEEEEEEEETTEEEEEEEEEECCSGGGGGGHHHHHTT----CSEEEE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCEEEEEEECCCCCCHHHHHHHHHHCC----CCEEEE T ss_conf 9998179977899999986480155435400111001221478846899872155632011332675237----754899 Q ss_pred HHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCCCC Q ss_conf 02120324799999999999999997248888999999999999986203500057777676645456654000036888 Q Ver_Hs_NP_0061 136 VADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLG 215 (492) Q Consensus 136 ~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lPLg 215 (492) |.|...|+++ +.+..|+..++.+... T Consensus 85 v~d~~~~~s~-~~~~~~~~~i~~~~~~----------------------------------------------------- 110 (170) T 1r2q_A 85 VYDITNEESF-ARAKNWVKELQRQASP----------------------------------------------------- 110 (170) T ss_dssp EEETTCHHHH-HHHHHHHHHHHHHSCT----------------------------------------------------- T ss_pred EEECCCCCCC-HHHHHHHHHHHHHHCC----------------------------------------------------- T ss_conf 8405555343-0144556655332037----------------------------------------------------- Q ss_pred CCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHH Q ss_conf 7622147994079985075225555420577477899999999999987087378845666356799999998887 Q Ver_Hs_NP_0061 216 DNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKT 291 (492) Q Consensus 216 eg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~Hrl 291 (492) ++|+++|.+|+|..+ ++.-..++ ++.||-.+++..+.||++...|++-+...|.+++ T Consensus 111 --------~~piilvgnK~Dl~~----~~~v~~~~-------~~~~a~~~~~~~~~~Sak~g~~i~elf~~l~~~i 167 (170) T 1r2q_A 111 --------NIVIALSGNKADLAN----KRAVDFQE-------AQSYADDNSLLFMETSAKTSMNVNEIFMAIAKKL 167 (170) T ss_dssp --------TCEEEEEEECGGGGG----GCCSCHHH-------HHHHHHHTTCEEEECCTTTCTTHHHHHHHHHHTS T ss_pred --------CCCEEECCCCCCHHH----HHHHHHHH-------HHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHH T ss_conf --------822441346430133----43102444-------4357886596289986278978889999999996 No 37 >cd04119 RJL RJL (RabJ-Like) subfamily. RJLs are found in many protists and as chimeras with C-terminal DNAJ domains in deuterostome metazoa. They are not found in plants, fungi, and protostome metazoa, suggesting a horizontal gene transfer between protists and deuterostome metazoa. RJLs lack any known membrane targeting signal and contain a degenerate phosphate/magnesium-binding 3 (PM3) motif, suggesting an impaired ability to hydrolyze GTP. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Probab=98.87 E-value=3.8e-07 Score=70.47 Aligned_columns=163 Identities=22% Q ss_pred EEEEECCCCCHHHHHHHHHC---CCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEE Q ss_conf 88860788548999998620---133678743103353021213473001005885676021135322477343302102 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTKLQG---AEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLV 133 (492) Q Consensus 57 ILvLG~~~sGKttLi~~Lq~---~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlV 133 (492) |+++|+.++|||+|+.++.. .+.....-|.+|....|.- .+...++.+|=..|...+.++.+....--+ .+ T Consensus 3 ivivGd~~vGKTsli~r~~~~~f~~~y~~Tig~~~~~k~i~~--~~~~~~l~iwDtaG~e~~~~~~~~~~~~a~----~~ 76 (168) T cd04119 3 VISMGNSGVGKSCIIKRYCEGRFVSKYLPTIGIDYGVKKVSV--RNKEVRVNFFDLSGHPEYLEVRNEFYKDTQ----GV 76 (168) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEE--CCEEEEEEEEECCCCHHHHHHHHHHHCCCC----EE T ss_conf 899807985489999887718016653650355555678888--794899998606898125788788723999----38 Q ss_pred EEHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCC Q ss_conf 00021203247999999999999999972488889999999999999862035000577776766454566540000368 Q Ver_Hs_NP_0061 134 IFVADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALP 213 (492) Q Consensus 134 vI~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lP 213 (492) +||-|.+.+-.+-. +++|+.-++.++.. .+ T Consensus 77 ilvydit~~~Sf~~-i~~w~~~~~~~~~~-------------------------------------------------~~ 106 (168) T cd04119 77 LLVYDVTDRQSFEA-LDSWLKEMKQEGGP-------------------------------------------------HG 106 (168) T ss_pred EEEEECCCHHHHHH-HHHHHHHHHHHCCC-------------------------------------------------CC T ss_conf 99985699778999-99999999986055-------------------------------------------------56 Q ss_pred CCCCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHC Q ss_conf 88762214799407998507522555542057747789999999999998708737884566635679999999888727 Q Ver_Hs_NP_0061 214 LGDNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTYG 293 (492) Q Consensus 214 Lgeg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~Hrlyg 293 (492) -.+. +|+++|.+|+| |...+.-..++. +.+|-++|+..|.||+|...|++.+.++|+.+++. T Consensus 107 ~~~~-------~~iilvGNK~D----l~~~r~V~~~~~-------~~~a~~~~~~~~E~SAk~~~nV~e~F~~l~~~i~d 168 (168) T cd04119 107 NMEN-------IVVVVCANKID----LTKHRAVSEDEG-------RLWAESKGFKYFETSACTGEGVNEMFQTLFSSIVD 168 (168) T ss_pred CCCC-------CEEEEEECCCC----CCCCCCCCHHHH-------HHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHCC T ss_conf 6687-------47999705323----323576798999-------99999649919999715897878999999998559 No 38 >1i2m_A RAN, GTP-binding nuclear protein RAN; beta-propeller, G fold or GTPase fold; 1.76A {Homo sapiens} SCOP: c.37.1.8 Probab=98.86 E-value=9.6e-08 Score=74.48 Aligned_columns=157 Identities=20% Q ss_pred EEEEECCCCCHHHHHHHHHC---CCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEE Q ss_conf 88860788548999998620---133678743103353021213473001005885676021135322477343302102 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTKLQG---AEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLV 133 (492) Q Consensus 57 ILvLG~~~sGKttLi~~Lq~---~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlV 133 (492) |+|+|+.++|||||+.+|.+ .+.....-|.+|....+ ...+..-++.+|-..|.-.+..+.+.....-+ .+ T Consensus 13 IvivG~~~vGKTsLi~~~~~~~f~~~~~~Ti~~d~~~~~~--~~~~~~~~l~i~Dt~g~~~~~~~~~~~~~~~~----~~ 86 (216) T 1i2m_A 13 LVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLVF--HTNRGPIKFNVWDTAGQEKFGGLRDGYYIQAQ----CA 86 (216) T ss_dssp EEEEECTTSSHHHHHHTTC-----CCEEEETTEEEEEEEE--CBTTCCEEEEEEECTTHHHHSSCGGGGTTTCC----EE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEE--CCCCCCCCEEECCCCCCHHHHHCCHHHHCCCE----EE T ss_conf 9988079987999999986383266524404566655430--36885211122243110122101001221300----12 Q ss_pred EEHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCC Q ss_conf 00021203247999999999999999972488889999999999999862035000577776766454566540000368 Q Ver_Hs_NP_0061 134 IFVADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALP 213 (492) Q Consensus 134 vI~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lP 213 (492) |+|.|.+++..| +++..|+.-+.....+. T Consensus 87 i~v~d~~~~~Sf-~~i~~~~~~~~~~~~~~-------------------------------------------------- 115 (216) T 1i2m_A 87 IIMFDVTSRVTY-KNVPNWHRDLVRVCENI-------------------------------------------------- 115 (216) T ss_dssp EEEEETTSGGGG-TTHHHHHHHHHHHHCSC-------------------------------------------------- T ss_pred EEECCCCCCCCH-HHHHHHHHHHHHHCCCC-------------------------------------------------- T ss_conf 311023311001-33567666667623882-------------------------------------------------- Q ss_pred CCCCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHC Q ss_conf 88762214799407998507522555542057747789999999999998708737884566635679999999888727 Q Ver_Hs_NP_0061 214 LGDNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTYG 293 (492) Q Consensus 214 Lgeg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~Hrlyg 293 (492) |+++|++|+| |..+..-.+ ...+|-.+++..+.||++...|++-+.++|...+++ T Consensus 116 ------------piilvgnK~D----l~~~~~~~~---------~~~~~~~~~~~~~e~SAk~g~gV~e~f~~l~~~i~~ 170 (216) T 1i2m_A 116 ------------PIVLCGNKVD----IKDRKVKAK---------SIVFHRKKNLQYYDISAKSNYNFEKPFLWLARKLIG 170 (216) T ss_dssp ------------CEEEEEECCC----CSCSCCTTT---------SHHHHSSCSSEEEEEBTTTTBTTTHHHHHHHHHHHT T ss_pred ------------EEEEEECCCC----CHHHHHHHH---------HHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHH T ss_conf ------------5887414665----202311689---------999999648965888516798888999999999850 Q ss_pred CC Q ss_conf 77 Q Ver_Hs_NP_0061 294 FH 295 (492) Q Consensus 294 fp 295 (492) .+ T Consensus 171 ~~ 172 (216) T 1i2m_A 171 DP 172 (216) T ss_dssp CT T ss_pred CC T ss_conf 34 No 39 >2bov_A RAla, RAS-related protein RAL-A; C3BOT, exoenzyme, RAla, GTPase, ribosylating toxin, GTP-binding, lipoprotein, prenylation; HET: GDP; 2.66A {Homo sapiens} Probab=98.86 E-value=1.1e-07 Score=74.08 Aligned_columns=160 Identities=14% Q ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEEEEH Q ss_conf 88860788548999998620133678743103353021213473001005885676021135322477343302102000 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTKLQGAEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLVIFV 136 (492) Q Consensus 57 ILvLG~~~sGKttLi~~Lq~~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlVvI~ 136 (492) |+|+|+.++|||||+.+|.+.+....-....-..+...-...+...++.+|-..|.-.+..+.+..+..-.+ +++| T Consensus 17 I~iiG~~~vGKTsLi~~l~~~~~~~~~~~t~~~~~~~~~~~~~~~~~l~i~d~~g~~~~~~~~~~~~~~~~~----~i~v 92 (206) T 2bov_A 17 VIMVGSGGVGKSALTLQFMYDEFVEDYEPTKADSYRKKVVLDGEEVQIDILDTAGQEDYAAIRDNYFRSGEG----FLCV 92 (206) T ss_dssp EEEECSTTSSHHHHHHHHHHSCCCTTCCTTCCEEEEEEEEETTEEEEEEEEECCCTTCCHHHHHHHHHHCSE----EEEE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEECCEEEEEEEEECCCCCCCCCCCCCCCCCCCE----EEEE T ss_conf 999827998789999998628316752563045789999834748999873024743113100000112201----1222 Q ss_pred HHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCCCCC Q ss_conf 21203247999999999999999972488889999999999999862035000577776766454566540000368887 Q Ver_Hs_NP_0061 137 ADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLGD 216 (492) Q Consensus 137 lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lPLge 216 (492) .|.+.+ .-++.+..|+..+......-. T Consensus 93 ~d~~~~-~s~~~~~~~~~~~~~~~~~~~---------------------------------------------------- 119 (206) T 2bov_A 93 FSITEM-ESFAATADFREQILRVKEDEN---------------------------------------------------- 119 (206) T ss_dssp EETTCH-HHHHHHHHHHHHHHHHTTCSC---------------------------------------------------- T ss_pred ECCCCH-HHHHHHHHHHHHHHHCCCCCC---------------------------------------------------- T ss_conf 114320-016889988666431147997---------------------------------------------------- Q ss_pred CCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHH Q ss_conf 6221479940799850752255554205774778999999999999870873788456663567999999988872 Q Ver_Hs_NP_0061 217 NVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTY 292 (492) Q Consensus 217 g~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~Hrly 292 (492) +|+++|++|+|. .++-.+-++.++.|+-+|++..|.||++...|++-+..++++.++ T Consensus 120 --------~piilv~nK~Dl-----------~~~~~v~~~~~~~~~~~~~~~~~~~Sa~~~~~i~~~f~~l~~~i~ 176 (206) T 2bov_A 120 --------VPFLLVGNKSDL-----------EDKRQVSVEEAKNRAEQWNVNYVETSAKTRANVDKVFFDLMREIR 176 (206) T ss_dssp --------CCEEEEEECTTC-----------GGGCCSCHHHHHHHHHHHTCEEEEECTTTCTTHHHHHHHHHHHHH T ss_pred --------CEEEEECCCCCC-----------HHCCCCCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHH T ss_conf --------079971476440-----------010467889999999964895589860589888899999999999 No 40 >2gf9_A RAS-related protein RAB-3D; G-protein, structural genomics, structural genomics consortium, SGC; HET: GDP; 1.53A {Homo sapiens} Probab=98.86 E-value=1.5e-06 Score=66.52 Aligned_columns=171 Identities=21% Q ss_pred HCCCCCCCCCC----EEEEEECCCCCHHHHHHHHHCCCCCCC-CCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCC Q ss_conf 17862278876----488860788548999998620133678-7431033530212134730010058856760211353 Q Ver_Hs_NP_0061 45 TRARSKLPSGK----NILVFGEDGSGKTTLMTKLQGAEHGKK-GRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLL 119 (492) Q Consensus 45 ~~~~~klp~~K----nILvLG~~~sGKttLi~~Lq~~e~~kk-g~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LL 119 (492) .++..-.|.|. -|+|+|+.++|||||+.+|.+-+.... -.-.+..+..+.-...+...++.+|-..|...+..+. T Consensus 9 ~~~~~~~p~~~d~~~KI~iiG~~~vGKSsLi~~l~~~~~~~~~~~t~~~~~~~~~~~~~~~~v~~~i~D~~g~~~~~~~~ 88 (189) T 2gf9_A 9 HHSSGLVPRGSDYMFKLLLIGNSSVGKTSFLFRYADDSFTPAFVSTVGIDFKVKTVYRHDKRIKLQIWDTAGQERYRTIT 88 (189) T ss_dssp -----CCCTTCSEEEEEEEECSTTSSHHHHHHHHHHSCCCCSCCCCCCCEEEEEEEEETTEEEEEEEEECCSCCSSCCSG T ss_pred CCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCEECCCEEEEEEECCEEEEEEEECCCCCCHHHHHH T ss_conf 34568898886725899998179987899999986480364524210012102445421158999884067742134555 Q ss_pred CCCCCCCCHHHEEEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCC Q ss_conf 22477343302102000212032479999999999999999724888899999999999998620350005777767664 Q Ver_Hs_NP_0061 120 KFAVSAESLPETLVIFVADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRG 199 (492) Q Consensus 120 k~al~~~si~~TlVvI~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~ 199 (492) ......-+ .++||.|++.+.++ +.+.+|...++..... T Consensus 89 ~~~~~~~~----~~iivfd~~~~~S~-~~~~~~~~~~~~~~~~------------------------------------- 126 (189) T 2gf9_A 89 TAYYRGAM----GFLLMYDIANQESF-AAVQDWATQIKTYSWD------------------------------------- 126 (189) T ss_dssp GGGGTTCS----EEEEEEETTCHHHH-HTHHHHHHHHHHHSCT------------------------------------- T ss_pred HHHCCCCE----EEEEEEECCCCHHH-HHHHHHHCCCCCCCCC------------------------------------- T ss_conf 87605971----89999850330123-3332100000102246------------------------------------- Q ss_pred CCCCCCCCHHCCCCCCCCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCC Q ss_conf 54566540000368887622147994079985075225555420577477899999999999987087378845666356 Q Ver_Hs_NP_0061 200 PLTSGSDEENVALPLGDNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKN 279 (492) Q Consensus 200 ~~~s~~de~~v~lPLgeg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kN 279 (492) ..|++||.+|+| |.+++.-..++ ++.|+-+++..++.||++...| T Consensus 127 ------------------------~~piiivgnK~D----l~~~~~v~~~e-------~~~~a~~~~~~~~e~Sa~~~~g 171 (189) T 2gf9_A 127 ------------------------NAQVILVGNKCD----LEDERVVPAED-------GRRLADDLGFEFFEASAKENIN 171 (189) T ss_dssp ------------------------TCEEEEEEECTT----CGGGCCSCHHH-------HHHHHHHHTCEEEECBTTTTBS T ss_pred ------------------------CEEEEEECCCCC----CHHHHHHHHHH-------HHHHHHHCCCCEEEEECCCCCC T ss_conf ------------------------624775013232----01232001789-------9999996599189996268978 Q ss_pred HHHHHHHHHHHHH Q ss_conf 7999999988872 Q Ver_Hs_NP_0061 280 LDLLYKYIVHKTY 292 (492) Q Consensus 280 l~lLykYi~Hrly 292 (492) ++.+...+++.++ T Consensus 172 I~elf~~i~~~i~ 184 (189) T 2gf9_A 172 VKQVFERLVDVIC 184 (189) T ss_dssp HHHHHHHHHHHHH T ss_pred HHHHHHHHHHHHH T ss_conf 8999999999999 No 41 >2dpx_A GTP-binding protein RAD; GTPase, small-G, RGK, signal transduction, diabetes; HET: GDP; 1.80A {Homo sapiens} Probab=98.86 E-value=7.6e-08 Score=75.14 Aligned_columns=159 Identities=21% Q ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEEEEH Q ss_conf 88860788548999998620133678743103353021213473001005885676021135322477343302102000 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTKLQGAEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLVIFV 136 (492) Q Consensus 57 ILvLG~~~sGKttLi~~Lq~~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlVvI~ 136 (492) |+|+|+.++|||||+.+|.+..........+-.|-....-+ +...++.+|-..|...+..+.+..+..-+ .+||| T Consensus 10 I~viG~~~~GKTsli~~l~~~~~~~~~~~~~~~~~~~i~~~-~~~~~l~i~D~~g~~~~~~~~~~~~~~~d----~~i~v 84 (174) T 2dpx_A 10 VLLLGAPGVGKSALARIFGGVEDGPEAEAAGHTYDRSIVVD-GEEASLMVYDIWEQDGGRWLPGHCMAMGD----AYVIV 84 (174) T ss_dssp EEEECCTTSSHHHHHHHHHTCC---------CEEEEEEEET-TEEEEEEEECC-------CCHHHHHTSCS----EEEEE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCEEEEEEEEEEEEC-CEEEEEEEEECCCCCCCHHHHHHHHHCCH----HHHHE T ss_conf 99980799879999999845636641230476455423660-40134777621000100111111110100----00000 Q ss_pred HHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCCCCC Q ss_conf 21203247999999999999999972488889999999999999862035000577776766454566540000368887 Q Ver_Hs_NP_0061 137 ADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLGD 216 (492) Q Consensus 137 lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lPLge 216 (492) .|.+.|..+ +.+..|..-+.++...-. T Consensus 85 ~d~~~~~s~-~~~~~~~~~i~~~~~~~~---------------------------------------------------- 111 (174) T 2dpx_A 85 YSVTDKGSF-EKASELRVQLRRARQTDD---------------------------------------------------- 111 (174) T ss_dssp EETTCHHHH-HHHHHHHHHHHHHC---C---------------------------------------------------- T ss_pred ECCCCCCCC-CCCCHHHHHHHHCCCCCC---------------------------------------------------- T ss_conf 002123420-100001234321011242---------------------------------------------------- Q ss_pred CCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHH Q ss_conf 6221479940799850752255554205774778999999999999870873788456663567999999988872 Q Ver_Hs_NP_0061 217 NVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTY 292 (492) Q Consensus 217 g~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~Hrly 292 (492) +|++||++|+|. .+...+..+-.|.|+-+||+..+.||++...|++-+.+-+++.++ T Consensus 112 --------~piiiv~nK~Dl-----------~~~~~v~~~e~~~~~~~~~~~~~~~Sak~~~~i~~~f~~l~~~i~ 168 (174) T 2dpx_A 112 --------VPIILVGNKSDL-----------VRSREVSVDEGRACAVVFDCKFIETSAALHHNVQALFEGVVRQIR 168 (174) T ss_dssp --------CCEEEEEECTTC-----------CTTCCSCHHHHHHHHHHHTSEEEECBTTTTBTHHHHHHHHHHHHH T ss_pred --------EEEEEEHHCCCH-----------HHHCCCCHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHH T ss_conf --------020100111221-----------231155278888899865971899861689788899999999999 No 42 >pfam00071 Ras Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices. Probab=98.86 E-value=2.6e-07 Score=71.54 Aligned_columns=159 Identities=23% Q ss_pred EEEEECCCCCHHHHHHH-HHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEEEE Q ss_conf 88860788548999998-62013367874310335302121347300100588567602113532247734330210200 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTK-LQGAEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLVIF 135 (492) Q Consensus 57 ILvLG~~~sGKttLi~~-Lq~~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlVvI 135 (492) |+|+|+.++|||+|+.+ +.+.....--.-++..+....=...+..-.+.+|-..|.-.+..+.+..+.- -..++| T Consensus 2 i~viG~~~vGKTsli~r~~~~~f~~~~~~Ti~~~~~~k~v~~~~~~~~l~i~Dt~g~e~~~~~~~~~~~~----ad~~il 77 (162) T pfam00071 2 LVLVGDGGVGKSSLLIRFTQNKFPEEYIPTIGVDFYTKTIEVDGKTVKLQIWDTAGQERFRSLRPAYYRG----AQGFLL 77 (162) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEEECCEEEEEEEEECCCCCHHHHHHHHHCCC----CCEEEE T ss_conf 7888179966899999986383276544201015789999873679999998669980135675865048----988999 Q ss_pred HHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCCCC Q ss_conf 02120324799999999999999997248888999999999999986203500057777676645456654000036888 Q Ver_Hs_NP_0061 136 VADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLG 215 (492) Q Consensus 136 ~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lPLg 215 (492) |-|++.. .-++.++.|+..++.+... T Consensus 78 vfd~~~~-~Sf~~i~~w~~~i~~~~~~----------------------------------------------------- 103 (162) T pfam00071 78 VYDITSR-DSFENVKKWLEEILRHADE----------------------------------------------------- 103 (162) T ss_pred EEECCCH-HHHHHHHHHHHHHHHHCCC----------------------------------------------------- T ss_conf 9877997-8999999999999984599----------------------------------------------------- Q ss_pred CCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHH Q ss_conf 76221479940799850752255554205774778999999999999870873788456663567999999988872 Q Ver_Hs_NP_0061 216 DNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTY 292 (492) Q Consensus 216 eg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~Hrly 292 (492) .+|+++|++|+|. .+.-.+-.+-.+.||-++++..|.||++...|++-+.+.|.-+++ T Consensus 104 --------~~piilvgnK~Dl-----------~~~~~i~~~e~~~~~~~~~~~y~e~Sak~g~gI~e~F~~l~~~i~ 161 (162) T pfam00071 104 --------NVPIVLVGNKCDL-----------EDQRVVSTEEGEALAKELGLPFMETSAKTNTNVEEAFEELAREIL 161 (162) T ss_pred --------CCEEEEEEECCHH-----------HHHCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHH T ss_conf --------9489998504201-----------121167688999999964995999971479888899999999980 No 43 >cd01863 Rab18 Rab18 subfamily. Mammalian Rab18 is implicated in endocytic transport and is expressed most highly in polarized epithelial cells. However, trypanosomal Rab, TbRAB18, is upregulated in the BSF (Blood Stream Form) stage and localized predominantly to elements of the Golgi complex. In human and mouse cells, Rab18 has been identified in lipid droplets, organelles that store neutral lipids. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site at the C-terminus, with sequence motifs CC, CXC, or CCX. Lipid binding is essential for membrane attachment, a key feature of mos Probab=98.85 E-value=2.6e-07 Score=71.53 Aligned_columns=156 Identities=23% Q ss_pred EEEEECCCCCHHHHHHHHHC---CCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEE Q ss_conf 88860788548999998620---133678743103353021213473001005885676021135322477343302102 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTKLQG---AEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLV 133 (492) Q Consensus 57 ILvLG~~~sGKttLi~~Lq~---~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlV 133 (492) |+++|+.++|||+|+.++-. .+.....-|.+|.-..|.- .+...++.+|=..|.-.+..|.+....--+ .+ T Consensus 3 iv~iG~~~VGKTsli~r~~~~~f~~~~~~Ti~~~~~~k~i~~--~~~~~~l~iwDt~G~e~~~~l~~~~~~~~~----~~ 76 (161) T cd01863 3 ILLIGDSGVGKSSLLLRFTDDTFDPDLAATIGVDFKVKTLTV--DGKKVKLAIWDTAGQERFRTLTSSYYRGAQ----GV 76 (161) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEE--CCEEEEEEEEECCCCCHHHHHHHHHCCCCC----EE T ss_conf 899807996589999998628207765651000245889989--896999999754887101245475435998----79 Q ss_pred EEHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCC Q ss_conf 00021203247999999999999999972488889999999999999862035000577776766454566540000368 Q Ver_Hs_NP_0061 134 IFVADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALP 213 (492) Q Consensus 134 vI~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lP 213 (492) |||-|.+.+ .=.+++++|+.-++.+-..-. T Consensus 77 i~vfd~t~~-~Sf~~i~~w~~~i~~~~~~~~------------------------------------------------- 106 (161) T cd01863 77 ILVYDVTRR-DTFTNLETWLNELETYSTNND------------------------------------------------- 106 (161) T ss_pred EEEEECCCH-HHHHHHHHHHHHHHHHCCCCC------------------------------------------------- T ss_conf 999856986-799999999999997338999------------------------------------------------- Q ss_pred CCCCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHH Q ss_conf 887622147994079985075225555420577477899999999999987087378845666356799999998887 Q Ver_Hs_NP_0061 214 LGDNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKT 291 (492) Q Consensus 214 Lgeg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~Hrl 291 (492) +|+++|.+|+|. +...+...-.+.+|.++|+..+.||++...|++-+.++|+.++ T Consensus 107 -----------~~~ilvGNK~Dl------------~~r~v~~~e~~~~a~~~~~~~~e~SAk~~~nv~e~F~~l~~~i 161 (161) T cd01863 107 -----------IVKMLVGNKIDK------------ENREVTREEGLKFARKHNMLFIETSAKTRDGVQQAFEELVEKI 161 (161) T ss_pred -----------CEEEEECCCCCC------------CCCCCCHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHC T ss_conf -----------389996123343------------0004888899999996699299997058978789999999849 No 44 >e1x1ra1 c.37.1.8 (A:10-178) Ras-related protein M-Ras (XRas) {Mouse (Mus musculus) [TaxID:10090]} SCOP: u1x1sa_ Probab=98.85 E-value=1.5e-07 Score=73.18 Aligned_columns=164 Identities=18% Q ss_pred CCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHH Q ss_conf 78876488860788548999998620133678743103353021213473001005885676021135322477343302 Q Ver_Hs_NP_0061 51 LPSGKNILVFGEDGSGKTTLMTKLQGAEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPE 130 (492) Q Consensus 51 lp~~KnILvLG~~~sGKttLi~~Lq~~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~ 130 (492) ||. =-|+|+|+.++|||||+.++.+.+.........-......-...+..-.+.+|-..|...+..+.+..+.. - T Consensus 2 ~~~-~Ki~iiG~~~vGKTsli~~~~~~~~~~~~~~t~~~~~~~~~~~~~~~~~~~i~D~~g~~~~~~~~~~~~~~----~ 76 (169) T e1x1ra1 2 LPT-YKLVVVGDGGVGKSALTIQFFQKIFVPDYDPTIEDSYLKHTEIDNQWAILDVLDTAGQEEFSAMREQYMRT----G 76 (169) T ss_pred CCE-EEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEECCEEEEEECCEEEEEEEEEECCCCCCHHHHHHHCCC----C T ss_conf 974-88999826998789999998627237665642000211589971337787787605765320235876069----7 Q ss_pred EEEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHC Q ss_conf 10200021203247999999999999999972488889999999999999862035000577776766454566540000 Q Ver_Hs_NP_0061 131 TLVIFVADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENV 210 (492) Q Consensus 131 TlVvI~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v 210 (492) ..++||.|.+.++++-. +.+|+..+. T Consensus 77 ~~~ilv~d~~~~~s~~~-~~~~~~~i~----------------------------------------------------- 102 (169) T e1x1ra1 77 DGFLIVYSVTDKASFEH-VDRFHQLIL----------------------------------------------------- 102 (169) T ss_pred EEEEEEEECCCCCCCCC-CHHHHHHHH----------------------------------------------------- T ss_conf 58999853341000120-004678887----------------------------------------------------- Q ss_pred CCCCCCCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCC-CHHHHHHHHHH Q ss_conf 36888762214799407998507522555542057747789999999999998708737884566635-67999999988 Q Ver_Hs_NP_0061 211 ALPLGDNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEK-NLDLLYKYIVH 289 (492) Q Consensus 211 ~lPLgeg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~k-Nl~lLykYi~H 289 (492) .....-.+|++||++|+|. .++-.+.++.++.||-++++..+.||+|... |++-+...|++ T Consensus 103 -------~~~~~~~~piilvgnK~Dl-----------~~~~~v~~~e~~~~~~~~~~~~~e~SAk~~~~nv~~~f~~l~~ 164 (169) T e1x1ra1 103 -------RVKDRESFPMILVANKVDL-----------MHLRKVTRDQGKEMATKYNIPYIETSAKDPPLNVDKTFHDLVR 164 (169) T ss_pred -------HHCCCCCCCEEEEEECCCH-----------HHCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHH T ss_conf -------5317687617999515681-----------0216669899999999659959999614588697899999999 Q ss_pred HH Q ss_conf 87 Q Ver_Hs_NP_0061 290 KT 291 (492) Q Consensus 290 rl 291 (492) .+ T Consensus 165 ~i 166 (169) T e1x1ra1 165 VI 166 (169) T ss_pred HH T ss_conf 99 No 45 >d1wmsa_ c.37.1.8 (A:) Rab9a {Human (Homo sapiens)} Probab=98.85 E-value=9.3e-07 Score=67.88 Aligned_columns=160 Identities=23% Q ss_pred EEEEECCCCCHHHHHHHHHC---CCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEE Q ss_conf 88860788548999998620---133678743103353021213473001005885676021135322477343302102 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTKLQG---AEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLV 133 (492) Q Consensus 57 ILvLG~~~sGKttLi~~Lq~---~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlV 133 (492) |+|+|..++|||+|+.++.+ .+......+.+|....+..+ +..-++.+|-..|.-.+..+.+..+..-. .+ T Consensus 9 ivivG~~~vGKTsLi~~~~~~~~~~~~~~t~~~~~~~~~i~~~--~~~i~l~~~d~~~~~~~~~~~~~~~~~~d----~~ 82 (174) T d1wmsa_ 9 VILLGDGGVGKSSLMNRYVTNKFDTQLFHTIGVEFLNKDLEVD--GHFVTMQIWDTAGQERFRSLRTPFYRGSD----CC 82 (174) T ss_dssp EEEECCTTSSHHHHHHHHHHSCCCC----CCSEEEEEEEEEET--TEEEEEEEEECCCCGGGHHHHGGGGTTCS----EE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEECEEEEEEEEC--CEEEEEEEEECCCCCHHHHHHHEECCCCE----EE T ss_conf 9998179987899999986381356533315511056799998--97999998312473001021100126865----89 Q ss_pred EEHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCC Q ss_conf 00021203247999999999999999972488889999999999999862035000577776766454566540000368 Q Ver_Hs_NP_0061 134 IFVADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALP 213 (492) Q Consensus 134 vI~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lP 213 (492) |+|.|.+.|+++ +.+..|..-++.+..... T Consensus 83 i~v~d~~~~~s~-~~i~~~~~~i~~~~~~~~------------------------------------------------- 112 (174) T d1wmsa_ 83 LLTFSVDDSQSF-QNLSNWKKEFIYYADVKE------------------------------------------------- 112 (174) T ss_dssp EEEEETTCHHHH-HTHHHHHHHHHHHHTCSC------------------------------------------------- T ss_pred EEEEECCCHHHH-HHHHHHHHHHHHHHCCCC------------------------------------------------- T ss_conf 998635886789-999899999998710036------------------------------------------------- Q ss_pred CCCCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCC-CEEEEECCCCCCCHHHHHHHHHHHHH Q ss_conf 88762214799407998507522555542057747789999999999998708-73788456663567999999988872 Q Ver_Hs_NP_0061 214 LGDNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYG-AALIYTSVKEEKNLDLLYKYIVHKTY 292 (492) Q Consensus 214 Lgeg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YG-AsLiYTS~ke~kNl~lLykYi~Hrly 292 (492) .-++|+++|++|+|.. +.....|+ ++.++-+++ ...|.||++...|++-+...++.+++ T Consensus 113 --------~~~~piiivgnK~Dl~-----~~~v~~ee-------~~~~~~~~~~~~~~e~Sak~~~~I~e~f~~li~~il 172 (174) T d1wmsa_ 113 --------PESFPFVILGNKIDIS-----ERQVSTEE-------AQAWCRDNGDYPYFETSAKDATNVAAAFEEAVRRVL 172 (174) T ss_dssp --------TTTSCEEEEEECTTCS-----SCSSCHHH-------HHHHHHHTTCCCEEECCTTTCTTHHHHHHHHHHHHH T ss_pred --------CCCCCEEEEECCCCCC-----CCCCCHHH-------HHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHH T ss_conf --------7885289995145754-----35569899-------999999707982799860589888899999999995 No 46 >1wms_A RAB-9, RAB9, RAS-related protein RAB-9A; GTPase; HET: GDP; 1.25A {Homo sapiens} SCOP: c.37.1.8 Probab=98.85 E-value=4.4e-07 Score=70.03 Aligned_columns=162 Identities=21% Q ss_pred EEEEECCCCCHHHHHHHHHCCC-CCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEEEE Q ss_conf 8886078854899999862013-367874310335302121347300100588567602113532247734330210200 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTKLQGAE-HGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLVIF 135 (492) Q Consensus 57 ILvLG~~~sGKttLi~~Lq~~e-~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlVvI 135 (492) |+|+|..++|||||+.+|.+.+ ........+..|....-...+..-.+.+|-..+...+..+.+..+.--. .+++ T Consensus 10 i~iiG~~~vGKSSLi~~l~~~~~~~~~~~t~~~~~~~~~~~~~~~~~~~~i~D~~~~~~~~~~~~~~~~~~~----~ii~ 85 (177) T 1wms_A 10 VILLGDGGVGKSSLMNRYVTNKFDTQLFHTIGVEFLNKDLEVDGHFVTMQIWDTAGQERFRSLRTPFYRGSD----CCLL 85 (177) T ss_dssp EEEECCTTSSHHHHHHHHHHSCCCC----CCSEEEEEEEEEETTEEEEEEEEECCCCGGGHHHHGGGGTTCS----EEEE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEECCCEEEEECCCCHHHHHHHHCCHHHCCCCC----CEEE T ss_conf 999817997689999998648026763574011246775322386122101441011233210101103654----0566 Q ss_pred HHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCCCC Q ss_conf 02120324799999999999999997248888999999999999986203500057777676645456654000036888 Q Ver_Hs_NP_0061 136 VADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLG 215 (492) Q Consensus 136 ~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lPLg 215 (492) |.|.+.++++-. +..|+.-++.+....... T Consensus 86 v~d~~~~~s~~~-~~~~~~~i~~~~~~~~~~------------------------------------------------- 115 (177) T 1wms_A 86 TFSVDDSQSFQN-LSNWKKEFIYYADVKEPE------------------------------------------------- 115 (177) T ss_dssp EEETTCHHHHHT-HHHHHHHHHHHHTCSCTT------------------------------------------------- T ss_pred ECCCCCCCCCCH-HHHHHHHHHHHHHHCCCC------------------------------------------------- T ss_conf 335663000101-334378899874201345------------------------------------------------- Q ss_pred CCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEE-ECCCCCCCHHHHHHHHHHHHH Q ss_conf 76221479940799850752255554205774778999999999999870873788-456663567999999988872 Q Ver_Hs_NP_0061 216 DNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIY-TSVKEEKNLDLLYKYIVHKTY 292 (492) Q Consensus 216 eg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiY-TS~ke~kNl~lLykYi~Hrly 292 (492) ++|+++|++|+|. .+++-...+ ++.++-+++.--+| ||++...+++-+..-|+++++ T Consensus 116 --------~~piiiv~nK~Dl---~~~~v~~~~---------~~~~~~~~~~~~~~e~Sa~~g~gv~e~f~~l~~~i~ 173 (177) T 1wms_A 116 --------SFPFVILGNKIDI---SERQVSTEE---------AQAWCRDNGDYPYFETSAKDATNVAAAFEEAVRRVL 173 (177) T ss_dssp --------TSCEEEEEECTTC---SSCSSCHHH---------HHHHHHHTTCCCEEECCTTTCTTHHHHHHHHHHHHH T ss_pred --------CCCEEEEECCCCC---CHHCCCHHH---------HHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHH T ss_conf --------7737998135571---000356789---------999999807971899851688788899999999998 No 47 >e1z0fa_ c.37.1.8 (A:) Rab14 {Human (Homo sapiens) [TaxID:9606]} SCOP: u2aeda1 Probab=98.85 E-value=3.5e-07 Score=70.69 Aligned_columns=159 Identities=19% Q ss_pred EEEEECCCCCHHHHHHHHHCCC-CCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEEEE Q ss_conf 8886078854899999862013-367874310335302121347300100588567602113532247734330210200 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTKLQGAE-HGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLVIF 135 (492) Q Consensus 57 ILvLG~~~sGKttLi~~Lq~~e-~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlVvI 135 (492) |+|+|+.++|||||+.++.+.+ ...-....+..+....=...+...++.+|-..|......+.+..+..-. .+++ T Consensus 8 i~ivG~~~vGKTsLi~~~~~~~~~~~~~~t~~~~~~~~~~~~~~~~~~i~i~d~~g~~~~~~~~~~~~~~~d----~~i~ 83 (167) T e1z0fa_ 8 YIIIGDMGVGKSCLLHQFTEKKFMADCPHTIGVEFGTRIIEVSGQKIKLQIWDTAGQERFRAVTRSYYRGAA----GALM 83 (167) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEEECCCEEEEEEECCCCCCHHHHHHHHHCCCCC----EEEE T ss_conf 999817997799999998648235665412443320168987793257877216773012121032236886----7999 Q ss_pred HHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCCCC Q ss_conf 02120324799999999999999997248888999999999999986203500057777676645456654000036888 Q Ver_Hs_NP_0061 136 VADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLG 215 (492) Q Consensus 136 ~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lPLg 215 (492) +.|.+.+ ...+.+.+|..-+..+... T Consensus 84 v~d~~~~-~s~~~~~~~~~~~~~~~~~----------------------------------------------------- 109 (167) T e1z0fa_ 84 VYDITRR-STYNHLSSWLTDARNLTNP----------------------------------------------------- 109 (167) T ss_pred EEECCCC-HHHHHHHHHHHHHHHHHCC----------------------------------------------------- T ss_conf 9852774-0289999888889886178----------------------------------------------------- Q ss_pred CCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHH Q ss_conf 76221479940799850752255554205774778999999999999870873788456663567999999988872 Q Ver_Hs_NP_0061 216 DNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTY 292 (492) Q Consensus 216 eg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~Hrly 292 (492) .+|++||++|+|. +++-++..+-++.+|-.+|+.++.||++...|++-|..-+..++| T Consensus 110 --------~~~iiiv~nK~Dl-----------~~~~~i~~~e~~~~~~~~~~~~~e~Sa~~g~gi~elf~~i~~~iy 167 (167) T e1z0fa_ 110 --------NTVIILIGNKADL-----------EAQRDVTYEEAKQFAEENGLLFLEASAKTGENVEDAFLEAAKKIY 167 (167) T ss_pred --------CCEEEEEEECCHH-----------HHCCCCCHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHC T ss_conf --------7258875211021-----------000243178999999964982999962689888899999999719 No 48 >cd01866 Rab2 Rab2 subfamily. Rab2 is localized on cis-Golgi membranes and interacts with Golgi matrix proteins. Rab2 is also implicated in the maturation of vesicular tubular clusters (VTCs), which are microtubule-associated intermediates in transport between the ER and Golgi apparatus. In plants, Rab2 regulates vesicle trafficking between the ER and the Golgi bodies and is important to pollen tube growth. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site at the C-terminus, with sequence motifs CC, CXC, or CCX. Lipid binding is essential for membrane attachment, a key featur Probab=98.84 E-value=5.8e-07 Score=69.22 Aligned_columns=157 Identities=21% Q ss_pred EEEEECCCCCHHHHHHHHHC---CCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEE Q ss_conf 88860788548999998620---133678743103353021213473001005885676021135322477343302102 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTKLQG---AEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLV 133 (492) Q Consensus 57 ILvLG~~~sGKttLi~~Lq~---~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlV 133 (492) |+++|+.++|||+|+.++-. .+.....-|.+|....|.- .+...++.+|-..|.-.+..|.+....- -..+ T Consensus 7 ivliGd~~VGKTsli~r~~~~~f~~~~~~Ti~~~~~~k~i~~--~~~~v~l~iwDt~G~e~~~~l~~~~~~~----a~~~ 80 (168) T cd01866 7 YIIIGDTGVGKSCLLLQFTDKRFQPVHDLTIGVEFGARMITI--DGKQIKLQIWDTAGQESFRSITRSYYRG----AAGA 80 (168) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEECCC--CCCEEEEEEEECCCCCCHHHHHHHHCCC----CCEE T ss_conf 999816984389999998548257544530000001232146--7842899987538884112453653479----9779 Q ss_pred EEHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCC Q ss_conf 00021203247999999999999999972488889999999999999862035000577776766454566540000368 Q Ver_Hs_NP_0061 134 IFVADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALP 213 (492) Q Consensus 134 vI~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lP 213 (492) +||-|.+.+=.+ ++|+.|+..++++... T Consensus 81 iivfdvt~~~Sf-~~i~~w~~~~~~~~~~--------------------------------------------------- 108 (168) T cd01866 81 LLVYDITRRETF-NHLTSWLEDARQHSNS--------------------------------------------------- 108 (168) T ss_pred EEEEECCCHHHH-HHHHHHHHHHHHHCCC--------------------------------------------------- T ss_conf 999766997789-9999999999973699--------------------------------------------------- Q ss_pred CCCCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHH Q ss_conf 8876221479940799850752255554205774778999999999999870873788456663567999999988872 Q Ver_Hs_NP_0061 214 LGDNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTY 292 (492) Q Consensus 214 Lgeg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~Hrly 292 (492) .+|+++|.+|+| |+.++....++ .+.+|-++|+..+-||+|...|++-+...+.-.+| T Consensus 109 ----------~~piilVGnK~D----L~~~r~v~~~e-------~~~~a~~~~~~~~E~SAkt~~nV~~~F~~la~~i~ 166 (168) T cd01866 109 ----------NMTIMLIGNKCD----LESRREVSYEE-------GEAFAKEHGLIFMETSAKTASNVEEAFINTAKEIY 166 (168) T ss_pred ----------CCEEEEEECCHH----HHHHCCCCHHH-------HHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHH T ss_conf ----------968999833201----23304776889-------99999965984999861579887899999999997 No 49 >cd00876 Ras Ras family. The Ras family of the Ras superfamily includes classical N-Ras, H-Ras, and K-Ras, as well as R-Ras, Rap, Ral, Rheb, Rhes, ARHI, RERG, Rin/Rit, RSR1, RRP22, Ras2, Ras-dva, and RGK proteins. Ras proteins regulate cell growth, proliferation and differentiation. Ras is activated by guanine nucleotide exchange factors (GEFs) that release GDP and allow GTP binding. Many RasGEFs have been identified. These are sequestered in the cytosol until activation by growth factors triggers recruitment to the plasma membrane or Golgi, where the GEF colocalizes with Ras. Active GTP-bound Ras interacts with several effector proteins: among the best characterized are the Raf kinases, phosphatidylinositol 3-kinase (PI3K), RalGEFs and NORE/MST1. Most Ras proteins contain a lipid modification site at the C-terminus, with a typical sequence motif CaaX, where a = an aliphatic amino acid and X = any amino acid. Lipid binding is essential for membrane attachment, a key feature of m Probab=98.84 E-value=2.1e-07 Score=72.25 Aligned_columns=159 Identities=18% Q ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEEEEH Q ss_conf 88860788548999998620133678743103353021213473001005885676021135322477343302102000 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTKLQGAEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLVIFV 136 (492) Q Consensus 57 ILvLG~~~sGKttLi~~Lq~~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlVvI~ 136 (492) |+++|+.++|||+|+.++-..+-...-..----.....-...+...++.+|=..|.-.+..+.+..+.--+ .++|| T Consensus 2 i~~iGd~~vGKTsli~r~~~~~f~~~~~~ti~~~~~k~~~~~~~~~~l~i~Dt~G~e~~~~~~~~~~~~a~----~~iiv 77 (160) T cd00876 2 VVVLGAGGVGKSAITIQFVKGTFVEEYDPTIEDSYRKTIVVDGETYTLDILDTAGQEEFSAMRDLYIRQGD----GFILV 77 (160) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCHHHEEEEEEEECCEEEEEEEEECCCCHHHHHHHHHHHCCCC----EEEEE T ss_conf 78880799668999999872810675354200226778888482899998635884133468887640461----78999 Q ss_pred HHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCCCCC Q ss_conf 21203247999999999999999972488889999999999999862035000577776766454566540000368887 Q Ver_Hs_NP_0061 137 ADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLGD 216 (492) Q Consensus 137 lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lPLge 216 (492) -|.+.+-++ +.++.|+.-++ T Consensus 78 fdi~~~~Sf-~~i~~w~~~i~----------------------------------------------------------- 97 (160) T cd00876 78 YSITDRESF-EEIKGYREQIL----------------------------------------------------------- 97 (160) T ss_pred EECCCHHHH-HHHHHHHHHHH----------------------------------------------------------- T ss_conf 866997799-99999999999----------------------------------------------------------- Q ss_pred CCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHH Q ss_conf 622147994079985075225555420577477899999999999987087378845666356799999998887 Q Ver_Hs_NP_0061 217 NVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKT 291 (492) Q Consensus 217 g~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~Hrl 291 (492) ....+-.+|+++|++|+|. .++..+-.+-.+.||-++++..+.||+|...|++-+.++|+-.+ T Consensus 98 -~~~~~~~~piilvgNK~Dl-----------~~~r~v~~~e~~~~a~~~~~~~~e~Sak~~~nV~~~F~~i~~~i 160 (160) T cd00876 98 -RVKDDEDIPIVLVGNKCDL-----------ENERQVSKEEGKALAKEWGCPFIETSAKDNINIDEVFKLLVREI 160 (160) T ss_pred -HHCCCCCCEEEEEECCCCC-----------HHHCCCCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHC T ss_conf -8538999679998213263-----------00116768899999996499699997048988889999999829 No 50 >1z08_A RAS-related protein RAB-21; RAB GTPase, vesicular trafficking, protein transport; HET: GNP; 1.80A {Homo sapiens} SCOP: c.37.1.8 Probab=98.84 E-value=2.6e-06 Score=64.83 Aligned_columns=159 Identities=23% Q ss_pred EEEEECCCCCHHHHHHHHHCCC-CCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEEEE Q ss_conf 8886078854899999862013-367874310335302121347300100588567602113532247734330210200 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTKLQGAE-HGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLVIF 135 (492) Q Consensus 57 ILvLG~~~sGKttLi~~Lq~~e-~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlVvI 135 (492) |+|+|..++||||||.+|.+.+ ...........+....=...+..-++.+|-..+...+..+.+..... -..+++ T Consensus 9 i~ivG~~~vGKSsLi~~l~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~l~~~d~~~~~~~~~~~~~~~~~----~~~~i~ 84 (170) T 1z08_A 9 VVLLGEGCVGKTSLVLRYCENKFNDKHITTLGASFLTKKLNIGGKRVNLAIWDTAGQERFHALGPIYYRD----SNGAIL 84 (170) T ss_dssp EEEECCTTSCHHHHHHHHHHCCCCSSCCCCCSCEEEEEEEESSSCEEEEEEEECCCC-------CCSSTT----CSEEEE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCEEEEEEEECCCCHHHHCCCCHHHHCC----CCEEEE T ss_conf 8998179977899999986580365444323320113330266147887530132100001123022205----625788 Q ss_pred HHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCCCC Q ss_conf 02120324799999999999999997248888999999999999986203500057777676645456654000036888 Q Ver_Hs_NP_0061 136 VADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLG 215 (492) Q Consensus 136 ~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lPLg 215 (492) +-|++.+..+- .+.+|+..++..... T Consensus 85 v~d~~~~~s~~-~~~~~~~~~~~~~~~----------------------------------------------------- 110 (170) T 1z08_A 85 VYDITDEDSFQ-KVKNWVKELRKMLGN----------------------------------------------------- 110 (170) T ss_dssp EEETTCHHHHH-HHHHHHHHHHHHHGG----------------------------------------------------- T ss_pred EECCCCCCCCH-HHHHHHHHHCCCCCC----------------------------------------------------- T ss_conf 73143233200-011211000002455----------------------------------------------------- Q ss_pred CCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHH Q ss_conf 76221479940799850752255554205774778999999999999870873788456663567999999988872 Q Ver_Hs_NP_0061 216 DNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTY 292 (492) Q Consensus 216 eg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~Hrly 292 (492) .+|+++|++|+| |.++..-..|+ ++.++-.+++..+.||++...|++-|...++.+++ T Consensus 111 --------~~p~ilVgnK~D----l~~~~~i~~~~-------~~~~~~~~~~~~~e~Sa~~g~gi~~lf~~i~~~i~ 168 (170) T 1z08_A 111 --------EICLCIVGNKID----LEKERHVSIQE-------AESYAESVGAKHYHTSAKQNKGIEELFLDLCKRMI 168 (170) T ss_dssp --------GSEEEEEEECGG----GGGGCCSCHHH-------HHHHHHHTTCEEEEEBTTTTBSHHHHHHHHHHHHH T ss_pred --------CCCEEECCCCCH----HHHHCCCCHHH-------HHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHH T ss_conf --------542122034401----11110345789-------99999964993899961589788899999999983 No 51 >e1z08a1 c.37.1.8 (A:17-183) Rab21 {Human (Homo sapiens) [TaxID:9606]} SCOP: u1z08d_ u1yzta1 u1yzua_ Probab=98.84 E-value=1.4e-07 Score=73.48 Aligned_columns=157 Identities=20% Q ss_pred EEEEECCCCCHHHHHHHHHC---CCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEE Q ss_conf 88860788548999998620---133678743103353021213473001005885676021135322477343302102 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTKLQG---AEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLV 133 (492) Q Consensus 57 ILvLG~~~sGKttLi~~Lq~---~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlV 133 (492) |+|+|..++|||+|+.+|.+ .+......+.++....+..+ +..-++.+|-..|...+....+.....-+ .+ T Consensus 6 i~ivG~~~vGKSsLi~~l~~~~~~~~~~~~~~~~~~~~~~~~~--~~~~~l~i~d~~g~~~~~~~~~~~~~~~~----~~ 79 (167) T e1z08a1 6 VVLLGEGCVGKTSLVLRYCENKFNDKHITTLGASFLTKKLNIG--GKRVNLAIWDTAGQERFHALGPIYYRDSN----GA 79 (167) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEEEC--CEEEEEEEECCCCCHHHHHHHHHHHHCCC----CE T ss_conf 9998279987999999986580156634403420244799888--87999998425571355677676530001----02 Q ss_pred EEHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCC Q ss_conf 00021203247999999999999999972488889999999999999862035000577776766454566540000368 Q Ver_Hs_NP_0061 134 IFVADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALP 213 (492) Q Consensus 134 vI~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lP 213 (492) ++|.|.++++++ +.+..|+..++....+ T Consensus 80 i~v~d~~~~~s~-~~i~~~~~~i~~~~~~--------------------------------------------------- 107 (167) T e1z08a1 80 ILVYDITDEDSF-QKVKNWVKELRKMLGN--------------------------------------------------- 107 (167) T ss_pred EEEEECCCCCCH-HHHHHHHHHHHHHCCC--------------------------------------------------- T ss_conf 555302245657-8999999998752146--------------------------------------------------- Q ss_pred CCCCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHH Q ss_conf 8876221479940799850752255554205774778999999999999870873788456663567999999988872 Q Ver_Hs_NP_0061 214 LGDNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTY 292 (492) Q Consensus 214 Lgeg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~Hrly 292 (492) ++|++||.+|+|. .++-++-+..++.++-++|+..|.||++...|++-+...|..++. T Consensus 108 ----------~~piiivgnK~Dl-----------~~~~~i~~~~~~~~~~~~~~~~~e~Sa~~~~~i~e~f~~i~~~i~ 165 (167) T e1z08a1 108 ----------EICLCIVGNKIDL-----------EKERHVSIQEAESYAESVGAKHYHTSAKQNKGIEELFLDLCKRMI 165 (167) T ss_pred ----------CCCEEEEEECCCC-----------CCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHH T ss_conf ----------7422567623345-----------545567989999999973993899961589788899999999971 No 52 >1m7b_A RND3/RHOE small GTP-binding protein; small GTPase; HET: GTP; 2.00A {Homo sapiens} SCOP: c.37.1.8 Probab=98.83 E-value=2.3e-07 Score=71.87 Aligned_columns=171 Identities=20% Q ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEEEEH Q ss_conf 88860788548999998620133678743103353021213473001005885676021135322477343302102000 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTKLQGAEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLVIFV 136 (492) Q Consensus 57 ILvLG~~~sGKttLi~~Lq~~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlVvI~ 136 (492) |+|+|+.++|||||+.+|.+.+-...........+...-...+..-.+.+|=..|...+..+.+.... .-..+++| T Consensus 10 I~iiG~~~vGKSsLi~~~~~~~~~~~~~~t~~~~~~~~~~~~~~~~~l~i~D~~g~~~~~~~~~~~~~----~~~~ii~v 85 (184) T 1m7b_A 10 IVVVGDSQCGKTALLHVFAKDCFPENYVPTVFENYTASFEIDTQRIELSLWDTSGSPYYDNVRPLSYP----DSDAVLIC 85 (184) T ss_dssp EEEEESTTSSHHHHHHHHHHSCCCSSCCCCSEEEEEEEEECSSCEEEEEEEEECCSGGGTTTGGGGCT----TCSEEEEE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEECCEEEEEEECCCCCCCCCCCCCHHHHC----CCEEEEEE T ss_conf 99981799878999999863843666354377756553220653477642145444333100001101----21246666 Q ss_pred HHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCCCCC Q ss_conf 21203247999999999999999972488889999999999999862035000577776766454566540000368887 Q Ver_Hs_NP_0061 137 ADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLGD 216 (492) Q Consensus 137 lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lPLge 216 (492) .|.+.+.++-+-++.|...++.+... T Consensus 86 ~d~~~~~sf~~~~~~~~~~~~~~~~~------------------------------------------------------ 111 (184) T 1m7b_A 86 FDISRPETLDSVLKKWKGEIQEFCPN------------------------------------------------------ 111 (184) T ss_dssp EETTCHHHHHHHHHTHHHHHHHHCTT------------------------------------------------------ T ss_pred EECCCHHHHHHHHHHHHHHHHHHCCC------------------------------------------------------ T ss_conf 40671656888888778888761799------------------------------------------------------ Q ss_pred CCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHH-HHHHHHHHHHCCCEEEE-ECCCCCCC-HHHHHHHHHHHHHC Q ss_conf 62214799407998507522555542057747789999-99999999870873788-45666356-79999999888727 Q Ver_Hs_NP_0061 217 NVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFI-QSHLRRFCLQYGAALIY-TSVKEEKN-LDLLYKYIVHKTYG 293 (492) Q Consensus 217 g~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~I-qq~LR~~cL~YGAsLiY-TS~ke~kN-l~lLykYi~Hrlyg 293 (492) +|+++|++|+|..+..........++...| .+-...+|=+.|+-.+| ||++...| ++-+...++.-.++ T Consensus 112 --------~piilvgnK~D~~~~~~~~~~~~~~~~~~i~~~~~~~~~~~~~~~~~~E~Sak~~~n~v~e~f~~~~~~~~~ 183 (184) T 1m7b_A 112 --------TKMLLVGCKSDLRTDVSTLVELSNHRQTPVSYDQGANMAKQIGAATYIECSALQSENSVRDIFHVATLACVN 183 (184) T ss_dssp --------CEEEEEEECGGGGGCHHHHHHHHTTTCCCCCHHHHHHHHHHHTCSEEEECBTTTBHHHHHHHHHHHHHHHHT T ss_pred --------CEEEEEECCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHC T ss_conf --------418998625475432036788775203355889999999971895389975146872489999999999960 No 53 >1c1y_A RAS-related protein RAP-1A; GTP-binding proteins, protein-protein complex, effectors; HET: GTP; 1.90A {Homo sapiens} SCOP: c.37.1.8 Probab=98.83 E-value=9.5e-07 Score=67.80 Aligned_columns=160 Identities=18% Q ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEEEEH Q ss_conf 88860788548999998620133678743103353021213473001005885676021135322477343302102000 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTKLQGAEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLVIFV 136 (492) Q Consensus 57 ILvLG~~~sGKttLi~~Lq~~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlVvI~ 136 (492) |+++|+.++|||||+.++.+.+....-...........-.-.+....+..|-..|.-.+..+.+.....-+ .+++| T Consensus 6 i~iiG~~~vGKTsli~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~d~~g~e~~~~~~~~~~~~~~----~~i~v 81 (167) T 1c1y_A 6 LVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDCQQCMLEILDTAGTEQFTAMRDLYMKNGQ----GFALV 81 (167) T ss_dssp EEEECSTTSSHHHHHHHHHHCCCCCSCCCCSEEEEEEEEESSSCEEEEEEEEECSSCSSTTHHHHHHHHCS----EEEEE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCEEEEEEEEECCCCCCCHHHHHHHHHHCC----CEEEE T ss_conf 89880799878999999862833655465220011121122574688776403463310133344531113----42788 Q ss_pred HHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCCCCC Q ss_conf 21203247999999999999999972488889999999999999862035000577776766454566540000368887 Q Ver_Hs_NP_0061 137 ADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLGD 216 (492) Q Consensus 137 lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lPLge 216 (492) .|.+.|.++ +.+..|..-+..+... T Consensus 82 ~d~~~~~s~-~~~~~~~~~~~~~~~~------------------------------------------------------ 106 (167) T 1c1y_A 82 YSITAQSTF-NDLQDLREQILRVKDT------------------------------------------------------ 106 (167) T ss_dssp EETTCHHHH-HTHHHHHHHHHHHHCC------------------------------------------------------ T ss_pred EECCCCHHH-HHHHHHHHHHHHHCCC------------------------------------------------------ T ss_conf 415670014-4556664333332057------------------------------------------------------ Q ss_pred CCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHC-CCEEEEECCCCCCCHHHHHHHHHHHHH Q ss_conf 6221479940799850752255554205774778999999999999870-873788456663567999999988872 Q Ver_Hs_NP_0061 217 NVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQY-GAALIYTSVKEEKNLDLLYKYIVHKTY 292 (492) Q Consensus 217 g~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~Y-GAsLiYTS~ke~kNl~lLykYi~Hrly 292 (492) -.+|+++|++|+|..+ ++....|+. +.++-+| +...+.||++...|++-+...++..++ T Consensus 107 ------~~~~iilv~nK~Dl~~----~~~v~~~~~-------~~~~~~~~~~~~~e~Sak~~~~i~elf~~i~~~i~ 166 (167) T 1c1y_A 107 ------EDVPMILVGNKCDLED----ERVVGKEQG-------QNLARQWCNCAFLESSAKSKINVNEIFYDLVRQIN 166 (167) T ss_dssp ------SCCCEEEEEECTTCGG----GCCSCHHHH-------HHHHHHTTSCEEEECBTTTTBSHHHHHHHHHHHHT T ss_pred ------CCCEEEEEECCCCCHH----HHCCCHHHH-------HHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHC T ss_conf ------8850899822654001----214667899-------99999835971899861688687899999999862 No 54 >e2f7sa1 c.37.1.8 (A:5-190) Rab27b {Human (Homo sapiens) [TaxID:9606]} SCOP: u2f7sb_ Probab=98.83 E-value=3.4e-07 Score=70.77 Aligned_columns=160 Identities=18% Q ss_pred EEEEECCCCCHHHHHHHHHC---CCCCCCCCCCEEEEEEC--------CCCCCCCCCCCCEEEECCCCCCCCCCCCCCCC Q ss_conf 88860788548999998620---13367874310335302--------12134730010058856760211353224773 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTKLQG---AEHGKKGRGLEYLYLSV--------HDEDRDDHTRCNVWILDGDLYHKGLLKFAVSA 125 (492) Q Consensus 57 ILvLG~~~sGKttLi~~Lq~---~e~~kkg~gLeY~Yl~V--------~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~ 125 (492) |+++|..++|||||+.+|.+ .+......+.+|....+ ..........+++|-..|.-.+..+.+..+.. T Consensus 8 i~ivG~~~vGKSsLi~~l~~~~~~~~~~~t~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~d~~~~~~~~~~~~~~~~~ 87 (186) T e2f7sa1 8 LLALGDSGVGKTTFLYRYTDNKFNPKFITTVGIDFREKRVVYNAQGPNGSSGKAFKVHLQLWDTAGQERFRSLTTAFFRD 87 (186) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEECCCCCEEEECCCEEEEEEEEECCCHHHHHHHHHHHHCC T ss_conf 99981799879999999865811665145430135799999867552000014405899987621023321010222004 Q ss_pred CCHHHEEEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCC Q ss_conf 43302102000212032479999999999999999724888899999999999998620350005777767664545665 Q Ver_Hs_NP_0061 126 ESLPETLVIFVADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGS 205 (492) Q Consensus 126 ~si~~TlVvI~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~ 205 (492) -. .||+|.|.+.++++-+ +..|+.-+. T Consensus 88 ~d----~ii~v~d~~~~~s~~~-~~~~~~~i~------------------------------------------------ 114 (186) T e2f7sa1 88 AM----GFLLMFDLTSQQSFLN-VRNWMSQLQ------------------------------------------------ 114 (186) T ss_pred CC----EEEEECCCCCCCCHHH-HHHHHHHHH------------------------------------------------ T ss_conf 35----4898303456555678-989999999------------------------------------------------ Q ss_pred CCHHCCCCCCCCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHH Q ss_conf 40000368887622147994079985075225555420577477899999999999987087378845666356799999 Q Ver_Hs_NP_0061 206 DEENVALPLGDNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYK 285 (492) Q Consensus 206 de~~v~lPLgeg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLyk 285 (492) .-...-.+|++||++|+|. .+...+..+.++.|+-++|...+.||++...|++-+.. T Consensus 115 ------------~~~~~~~~piiiv~nK~Dl-----------~~~~~v~~~~~~~~~~~~~~~~~~~Sa~~g~gi~e~f~ 171 (186) T e2f7sa1 115 ------------ANAYCENPDIVLIGNKADL-----------PDQREVNERQARELADKYGIPYFETSAATGQNVEKAVE 171 (186) T ss_pred ------------HHCCCCCCEEEEEECCCCC-----------CCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHH T ss_conf ------------8506799648997405442-----------21247798999999996499399996268968889999 Q ss_pred HHHHHHH Q ss_conf 9988872 Q Ver_Hs_NP_0061 286 YIVHKTY 292 (492) Q Consensus 286 Yi~Hrly 292 (492) .|+..+. T Consensus 172 ~l~~~i~ 178 (186) T e2f7sa1 172 TLLDLIM 178 (186) T ss_pred HHHHHHH T ss_conf 9999999 No 55 >1z2a_A RAS-related protein RAB-23; RAB GTPase, vesicular trafficking, protein transport; HET: GDP; 1.90A {Mus musculus} SCOP: c.37.1.8 Probab=98.83 E-value=8.7e-07 Score=68.07 Aligned_columns=156 Identities=25% Q ss_pred EEEEECCCCCHHHHHHHHHC---CCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEE Q ss_conf 88860788548999998620---133678743103353021213473001005885676021135322477343302102 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTKLQG---AEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLV 133 (492) Q Consensus 57 ILvLG~~~sGKttLi~~Lq~---~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlV 133 (492) |+|+|..++|||||+.++.+ .+......+.+|....+.. .+....+.+|-..|...+..+.+..+.. -..+ T Consensus 8 i~ivG~~~vGKSsll~~~~~~~~~~~~~~t~~~~~~~~~~~~--~~~~~~~~~~d~~g~~~~~~~~~~~~~~----~~~~ 81 (168) T 1z2a_A 8 MVVVGNGAVGKSSMIQRYCKGIFTKDYKKTIGVDFLERQIQV--NDEDVRLMLWDTAGQEEFDAITKAYYRG----AQAC 81 (168) T ss_dssp EEEECSTTSSHHHHHHHHHHCCCCCCSSCCCSSSEEEEEEEE--TTEEEEEEEECCTTGGGTTCCCHHHHTT----CCEE T ss_pred EEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCEECCC--CCCEEEEEEECCCCCCCCCHHHHHHHHC----CHHH T ss_conf 999818997789999998638146542210122100001035--8815898641157753100101344311----0110 Q ss_pred EEHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCC Q ss_conf 00021203247999999999999999972488889999999999999862035000577776766454566540000368 Q Ver_Hs_NP_0061 134 IFVADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALP 213 (492) Q Consensus 134 vI~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lP 213 (492) +|+.|.+.|.++-. +.+|+..+..+ T Consensus 82 i~v~d~~~~~s~~~-~~~~~~~i~~~------------------------------------------------------ 106 (168) T 1z2a_A 82 VLVFSTTDRESFEA-ISSWREKVVAE------------------------------------------------------ 106 (168) T ss_dssp EEEEETTCHHHHHT-HHHHHHHHHHH------------------------------------------------------ T ss_pred HHHHHHHHHHHHHH-HHHHHHHHHHC------------------------------------------------------ T ss_conf 11111001123333-22100001210------------------------------------------------------ Q ss_pred CCCCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHH Q ss_conf 8876221479940799850752255554205774778999999999999870873788456663567999999988872 Q Ver_Hs_NP_0061 214 LGDNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTY 292 (492) Q Consensus 214 Lgeg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~Hrly 292 (492) .-.+|+++|++|+|... +.....| .++.|+-++|+..+.||++...|++-+..+|..+++ T Consensus 107 --------~~~~~iilvgnK~Dl~~----~~~v~~~-------~~~~~a~~~~~~~~e~Sa~~~~~i~~l~~~l~~~~l 166 (168) T 1z2a_A 107 --------VGDIPTALVQNKIDLLD----DSCIKNE-------EAEGLAKRLKLRFYRTSVKEDLNVSEVFKYLAEKHL 166 (168) T ss_dssp --------HCSCCEEEEEECGGGGG----GCSSCHH-------HHHHHHHHHTCEEEECBTTTTBSSHHHHHHHHHHHH T ss_pred --------CCCCEEEEEECCCCHHH----HHHHHHH-------HHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHH T ss_conf --------68823899731357123----2100478-------999999965991899861589788899999999997 No 56 >d1d5ca_ c.37.1.8 (A:) Rab6 {Malaria parasite (Plasmodium falciparum)} Probab=98.82 E-value=2.7e-07 Score=71.42 Aligned_columns=156 Identities=22% Q ss_pred EEEEECCCCCHHHHHHHHHC---CCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEE Q ss_conf 88860788548999998620---133678743103353021213473001005885676021135322477343302102 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTKLQG---AEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLV 133 (492) Q Consensus 57 ILvLG~~~sGKttLi~~Lq~---~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlV 133 (492) |+|+|..++|||||+.+|.+ .+....+.+.+|....+ ...+..-++.+|...|...+....+..+..-. .+ T Consensus 4 i~i~G~~~vGKSsLi~~l~~~~~~~~~~~t~~~~~~~~~~--~~~~~~~~~~~~d~~g~~~~~~~~~~~~~~~d----~~ 77 (162) T d1d5ca_ 4 LVFLGEQAVGKTSIITRFMYDTFDNNYQSTIGIDFLSKTL--YLDEGPVRLQLWDTAGQERFRSLIPSYIRDSA----AA 77 (162) T ss_dssp EEEECSTTSSHHHHHHHHHHSCCCTTCCCCCCCEEEEEEE--EETTEEEEEEEEECCCSGGGGGGHHHHHTTCS----EE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEE--EECCEEEEEEEECCCCCCHHHHHHHHHHCCCC----EE T ss_conf 8998179987999999986480156613315546777897--30881699986237652033456677632683----89 Q ss_pred EEHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCC Q ss_conf 00021203247999999999999999972488889999999999999862035000577776766454566540000368 Q Ver_Hs_NP_0061 134 IFVADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALP 213 (492) Q Consensus 134 vI~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lP 213 (492) +++.|.+.++.+ +++..|+.-++..... T Consensus 78 i~v~d~~~~~s~-~~~~~~l~~i~~~~~~--------------------------------------------------- 105 (162) T d1d5ca_ 78 IVVYDITNRQSF-ENTTKWIQDILNERGK--------------------------------------------------- 105 (162) T ss_dssp EEEEETTCHHHH-HTHHHHHHHHHHHHTT--------------------------------------------------- T ss_pred EEEEECCCCCCH-HHHHHHHHHHHHHCCC--------------------------------------------------- T ss_conf 999744666777-8999999999751248--------------------------------------------------- Q ss_pred CCCCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHH Q ss_conf 887622147994079985075225555420577477899999999999987087378845666356799999998887 Q Ver_Hs_NP_0061 214 LGDNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKT 291 (492) Q Consensus 214 Lgeg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~Hrl 291 (492) ..|++||++|+|. .++-.+....++.++-++|+..+.||++...|++-|.+-|.-++ T Consensus 106 ----------~~piilvgnK~Dl-----------~~~~~v~~~~~~~~~~~~~~~~~~~Sa~~g~gv~~lf~~i~~~l 162 (162) T d1d5ca_ 106 ----------DVIIALVGNKTDL-----------GDLRKVTYEEGMQKAQEYNTMFHETSAKAGHNIKVLFKKTASKL 162 (162) T ss_dssp ----------SSEEEEEEECGGG-----------GGGCCSCHHHHHHHHHHTTCEEEECBTTTTBSCHHHHHHHHHCC T ss_pred ----------CEEEEEEEECCCC-----------CCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHC T ss_conf ----------6578997521465-----------32245488999999996499299997268968789999999839 No 57 >2f9l_A RAB11B, member RAS oncogene family; RAB11B GTPase, vesicle transport; HET: GDP; 1.55A {Homo sapiens} SCOP: c.37.1.8 Probab=98.82 E-value=9.2e-07 Score=67.91 Aligned_columns=159 Identities=20% Q ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCC-CCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEEEE Q ss_conf 8886078854899999862013367874-310335302121347300100588567602113532247734330210200 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTKLQGAEHGKKGR-GLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLVIF 135 (492) Q Consensus 57 ILvLG~~~sGKttLi~~Lq~~e~~kkg~-gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlVvI 135 (492) |+|+|+.++|||+|+.++.+.+-..... ..+-.+....-...+....+.+|-..|...+..+.+..... ...++| T Consensus 8 i~ivG~~~vGKTsli~~~~~~~~~~~~~~t~~~~~~~~~~~~~~~~~~~~i~d~~~~~~~~~~~~~~~~~----~~~~i~ 83 (199) T 2f9l_A 8 VVLIGDSGVGKSNLLSRFTRNEFNLESKSTIGVEFATRSIQVDGKTIKAQIWDTAGQERYRRITSAYYRG----AVGALL 83 (199) T ss_dssp EEEESSTTSSHHHHHHHHHHSCCCC---CCCSCEEEEEEEEETTEEEEEEEEECSSGGGTTCCCHHHHTT----CSEEEE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEEEEEEEEEEEECCCCCCHHHHHHHHHHCC----CCEEEE T ss_conf 8998269976899999986283367645614544565554310035655652453210123566765047----837999 Q ss_pred HHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCCCC Q ss_conf 02120324799999999999999997248888999999999999986203500057777676645456654000036888 Q Ver_Hs_NP_0061 136 VADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLG 215 (492) Q Consensus 136 ~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lPLg 215 (492) |.|++.+.+ .+.+..|+..++.+. T Consensus 84 v~d~~~~~s-~~~~~~~~~~~~~~~------------------------------------------------------- 107 (199) T 2f9l_A 84 VYDIAKHLT-YENVERWLKELRDHA------------------------------------------------------- 107 (199) T ss_dssp EEETTCHHH-HHTHHHHHHHHHHHS------------------------------------------------------- T ss_pred EECCCCHHH-HHHHHHHHHHHHHHC------------------------------------------------------- T ss_conf 702678668-899998899999834------------------------------------------------------- Q ss_pred CCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHH Q ss_conf 76221479940799850752255554205774778999999999999870873788456663567999999988872 Q Ver_Hs_NP_0061 216 DNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTY 292 (492) Q Consensus 216 eg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~Hrly 292 (492) +-.+|+++|.+|+| |..+.....+ -.+.+|-.++...+.||++...|++-+...|+-.++ T Consensus 108 ------~~~~piilVgnK~D----l~~~~~~~~~-------e~~~~a~~~~~~~~e~Saktg~~v~elf~~l~~~i~ 167 (199) T 2f9l_A 108 ------DSNIVIMLVGNKSD----LRHLRAVPTD-------EARAFAEKNNLSFIETSALDSTNVEEAFKNILTEIY 167 (199) T ss_dssp ------CTTCEEEEEEECTT----CGGGCCSCHH-------HHHHHHHHTTCEEEECCTTTCTTHHHHHHHHHHHHH T ss_pred ------CCCCEEEEEEECCC----CCCCCCCCHH-------HHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHH T ss_conf ------89977999961057----2200146077-------888999973897378872378788899999999999 No 58 >1yzq_A Small GTP binding protein RAB6 isoform; RAB GTPase, vesicular trafficking, protein transport; HET: GNP; 1.78A {Homo sapiens} SCOP: c.37.1.8 Probab=98.82 E-value=4.7e-07 Score=69.85 Aligned_columns=161 Identities=21% Q ss_pred EEEEECCCCCHHHHHHHHHCCC-CCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEEEE Q ss_conf 8886078854899999862013-367874310335302121347300100588567602113532247734330210200 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTKLQGAE-HGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLVIF 135 (492) Q Consensus 57 ILvLG~~~sGKttLi~~Lq~~e-~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlVvI 135 (492) |+|+|..++|||||+.+|.+.+ ......-.+..|..+.-...+....+.+|-..|...+..+.+..+. .-..+++ T Consensus 9 I~iiG~~~vGKTsli~~~~~~~~~~~~~~t~~~~~~~~~~~~~~~~~~l~~~d~~g~~~~~~~~~~~~~----~~~~~i~ 84 (170) T 1yzq_A 9 LVFLGEQSVGKTSLITRFMYDSFDNTYQATIGIDFLSKTMYLEDRTIRLQLWDTAGQERFRSLIPSYIR----DSAAAVV 84 (170) T ss_dssp EEEEESTTSSHHHHHHHHHHSCCCSSCCCCCSEEEEEEEEECSSCEEEEEEEEECCSGGGGGGHHHHHT----TCSEEEE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEECCCCEEEEEECCCCCCCHHCCCCHHHHC----CCEEEEE T ss_conf 999807997789999998648245554421000343357611584676643146552100123300100----0113466 Q ss_pred HHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCCCC Q ss_conf 02120324799999999999999997248888999999999999986203500057777676645456654000036888 Q Ver_Hs_NP_0061 136 VADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLG 215 (492) Q Consensus 136 ~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lPLg 215 (492) +.|.+.|+.+. ++..|..-++.+... T Consensus 85 v~d~~~~~s~~-~i~~~~~~~~~~~~~----------------------------------------------------- 110 (170) T 1yzq_A 85 VYDITNVNSFQ-QTTKWIDDVRTERGS----------------------------------------------------- 110 (170) T ss_dssp EEETTCHHHHH-THHHHHHHHHHHHTT----------------------------------------------------- T ss_pred EECCCCHHHHH-HHHHHHHHHHHHCCC----------------------------------------------------- T ss_conf 43156602455-555655433221147----------------------------------------------------- Q ss_pred CCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHCC Q ss_conf 7622147994079985075225555420577477899999999999987087378845666356799999998887277 Q Ver_Hs_NP_0061 216 DNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTYGF 294 (492) Q Consensus 216 eg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~Hrlygf 294 (492) ..|+++|++|+|. .++-....+.++.++-+++...|.||++...|++-+..+|...+-|+ T Consensus 111 --------~~p~ilV~nK~Dl-----------~~~~~~~~~~~~~~~~~~~~~~~evSa~~~~gv~~~f~~i~~~l~~~ 170 (170) T 1yzq_A 111 --------DVIIMLVGNKTDL-----------ADKRQVSIEEGERKAKELNVMFIETSAKAGYNVKQLFRRVAAALPGM 170 (170) T ss_dssp --------SSEEEEEEECTTC-----------GGGCCSCHHHHHHHHHHTTCEEEECCTTTCTTHHHHHHHHHHHSCCC T ss_pred --------CCEEEEEECCCCH-----------HHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHCCC T ss_conf --------8417998625581-----------23332468999999996498189986268978889999999960379 No 59 >cd01868 Rab11_like Rab11-like. Rab11a, Rab11b, and Rab25 are closely related, evolutionary conserved Rab proteins that are differentially expressed. Rab11a is ubiquitously synthesized, Rab11b is enriched in brain and heart and Rab25 is only found in epithelia. Rab11/25 proteins seem to regulate recycling pathways from endosomes to the plasma membrane and to the trans-Golgi network. Furthermore, Rab11a is thought to function in the histamine-induced fusion of tubulovesicles containing H+, K+ ATPase with the plasma membrane in gastric parietal cells and in insulin-stimulated insertion of GLUT4 in the plasma membrane of cardiomyocytes. Overexpression of Rab25 has recently been observed in ovarian cancer and breast cancer, and has been correlated with worsened outcomes in both diseases. In addition, Rab25 overexpression has also been observed in prostate cancer, transitional cell carcinoma of the bladder, and invasive breast tumor cells. GTPase activating proteins (GAPs) interact with GTP Probab=98.82 E-value=3.4e-07 Score=70.80 Aligned_columns=159 Identities=21% Q ss_pred EEEEECCCCCHHHHHHH-HHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEEEE Q ss_conf 88860788548999998-62013367874310335302121347300100588567602113532247734330210200 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTK-LQGAEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLVIF 135 (492) Q Consensus 57 ILvLG~~~sGKttLi~~-Lq~~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlVvI 135 (492) |+++|+.++|||+|+.+ +++........-++..|....=.-.+....+.+|=.-|.-.+..+.+....--+ .++| T Consensus 6 i~~iG~~~VGKTsli~r~~~~~F~~~~~~Tig~~~~~k~v~~~~~~~~l~iwDtaG~e~~~~~~~~~~~~a~----~~ii 81 (165) T cd01868 6 IVLIGDSGVGKSNLLSRFTRNEFNLDSKSTIGVEFATRSIQIDGKTIKAQIWDTAGQERYRAITSAYYRGAV----GALL 81 (165) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEECCEEEEEEEECCCCCHHHHHHHHHHHCCCC----EEEE T ss_conf 999826996589999998638567455641001246889864890899998538986124577676504886----7999 Q ss_pred HHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCCCC Q ss_conf 02120324799999999999999997248888999999999999986203500057777676645456654000036888 Q Ver_Hs_NP_0061 136 VADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLG 215 (492) Q Consensus 136 ~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lPLg 215 (492) |-|.+.+-.+ +.+.+|+..++++..+ T Consensus 82 vyDit~~~Sf-~~i~~w~~~i~~~~~~----------------------------------------------------- 107 (165) T cd01868 82 VYDITKKQTF-ENVERWLKELRDHADS----------------------------------------------------- 107 (165) T ss_pred EEECCCHHHH-HHHHHHHHHHHHHCCC----------------------------------------------------- T ss_conf 9746997789-9999999999983289----------------------------------------------------- Q ss_pred CCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHH Q ss_conf 76221479940799850752255554205774778999999999999870873788456663567999999988872 Q Ver_Hs_NP_0061 216 DNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTY 292 (492) Q Consensus 216 eg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~Hrly 292 (492) .+|+++|.+|+|. .+...+-.+-.+.+|.++|+..+.||+|...|++-+.+.|.-.+| T Consensus 108 --------~~piilVGNK~DL-----------~~~r~v~~~e~~~~a~~~~~~~~e~Sak~g~ni~~~F~~l~~~i~ 165 (165) T cd01868 108 --------NIVIMLVGNKSDL-----------RHLRAVPTEEAKAFAEKNGLSFIETSALDGTNVEEAFKQLLTEIY 165 (165) T ss_pred --------CCEEEEEECCCCH-----------HHCCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCC T ss_conf --------9379998216562-----------120377688999999965994999971479888899999998709 No 60 >2pmx_A K-RAS; cancer, small GTPase, mutations, GTP analogue, structural genomics consortium, SGC; HET: GNP CIT; 2.27A {Homo sapiens} Probab=98.82 E-value=4.1e-07 Score=70.26 Aligned_columns=159 Identities=19% Q ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEEEEH Q ss_conf 88860788548999998620133678743103353021213473001005885676021135322477343302102000 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTKLQGAEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLVIFV 136 (492) Q Consensus 57 ILvLG~~~sGKttLi~~Lq~~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlVvI~ 136 (492) |+|+|+.++|||||+.+|.+.+........--..+...-...+..-++.+|-..|.-.+..+.+.....-.. ++++ T Consensus 24 I~iiG~~~vGKSsLi~rl~~~~~~~~~~~T~~~~~~~~~~~~~~~~~l~i~d~~g~e~~~~~~~~~~~~~~~----~i~v 99 (187) T 2pmx_A 24 LVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEG----FLCV 99 (187) T ss_dssp EEEEESTTSSHHHHHHHHHHSCCCCSCCCCSEEEEEEEEEETTEEEEEEEEEECSSCCCCHHHHHHHHTCSE----EEEE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEECCEEEEEEEECCCCCCCCCCCCHHHHCCCCC----EEEE T ss_conf 999807998789999998638025764412310256889774768999864036643323112223102342----1356 Q ss_pred HHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCCCCC Q ss_conf 21203247999999999999999972488889999999999999862035000577776766454566540000368887 Q Ver_Hs_NP_0061 137 ADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLGD 216 (492) Q Consensus 137 lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lPLge 216 (492) .|.+.+.. .+.+..|...++.....-+ T Consensus 100 ~d~~~~~s-~~~~~~~~~~i~~~~~~~~---------------------------------------------------- 126 (187) T 2pmx_A 100 FAINNTKS-FEDIHHYREQIKRVKDSED---------------------------------------------------- 126 (187) T ss_dssp EETTCHHH-HHTHHHHHHHHHHHHTCSC---------------------------------------------------- T ss_pred EEECCHHH-HHHHHHHHHHHHHHCCCCE---------------------------------------------------- T ss_conf 54110023-3332245556654058972---------------------------------------------------- Q ss_pred CCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHH Q ss_conf 6221479940799850752255554205774778999999999999870873788456663567999999988872 Q Ver_Hs_NP_0061 217 NVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTY 292 (492) Q Consensus 217 g~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~Hrly 292 (492) +|+++|++|+|. -+++-...+ ++.||-++++..+.||++...|++-+..+|+..+. T Consensus 127 --------~p~iivgnK~Dl---~~~~v~~~~---------~~~~~~~~~~~~~evSak~g~gI~~lf~~i~~~i~ 182 (187) T 2pmx_A 127 --------VPMVLVGNKCDL---PSRTVDTKQ---------AQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIR 182 (187) T ss_dssp --------CCEEEEEECTTS---SCCCSCHHH---------HHHHHHHHTCCEEECCTTTCTTHHHHHHHHHHHHH T ss_pred --------EEEEECCCCCCH---HHHCCCHHH---------HHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHH T ss_conf --------799970132572---240588889---------99999964993999961689788899999999999 No 61 >1z0f_A RAB14, member RAS oncogene family; RAB GTPase, vesicular trafficking, protein transport; HET: GDP; 2.15A {Homo sapiens} SCOP: c.37.1.8 Probab=98.82 E-value=1.8e-07 Score=72.66 Aligned_columns=167 Identities=17% Q ss_pred CCCCCCCC----CEEEEEECCCCCHHHHHHHHHC---CCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCC Q ss_conf 86227887----6488860788548999998620---1336787431033530212134730010058856760211353 Q Ver_Hs_NP_0061 47 ARSKLPSG----KNILVFGEDGSGKTTLMTKLQG---AEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLL 119 (492) Q Consensus 47 ~~~klp~~----KnILvLG~~~sGKttLi~~Lq~---~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LL 119 (492) ++.+.|.. =-|+|+|+.++|||||+.++.+ .++.....+..|....+.. ++..-++.+|-..|...+..+. T Consensus 4 ~~~~~~~~~~~~~Ki~iiG~~~vGKTSli~~~~~~~~~~~~~~t~~~~~~~~~~~~--~~~~~~~~i~d~~g~~~~~~~~ 81 (179) T 1z0f_A 4 GSATAPYNYSYIFKYIIIGDMGVGKSCLLHQFTEKKFMADCPHTIGVEFGTRIIEV--SGQKIKLQIWDTAGQERFRAVT 81 (179) T ss_dssp -------CCSEEEEEEEECSTTSSHHHHHHHHHHSCCCSSCTTSCCCCEEEEEEEE--TTEEEEEEEEECTTGGGTCHHH T ss_pred CCCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEEE--CCCEEEEEEECCCCCCCCCCCC T ss_conf 66678767533689999807997689999998628327763531553357888752--1856865553167743223221 Q ss_pred CCCCCCCCHHHEEEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCC Q ss_conf 22477343302102000212032479999999999999999724888899999999999998620350005777767664 Q Ver_Hs_NP_0061 120 KFAVSAESLPETLVIFVADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRG 199 (492) Q Consensus 120 k~al~~~si~~TlVvI~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~ 199 (492) +..+.--. .+++|-|++.+.++-.-...|..+.+... T Consensus 82 ~~~~~~~~----~~i~v~d~~~~~s~~~~~~~~~~~~~~~~--------------------------------------- 118 (179) T 1z0f_A 82 RSYYRGAA----GALMVYDITRRSTYNHLSSWLTDARNLTN--------------------------------------- 118 (179) T ss_dssp HHHHHTCS----EEEEEEETTCHHHHHTHHHHHHHHHHHSC--------------------------------------- T ss_pred HHHHCCCC----EEEEEEECCCCCCHHHHHHHHHHHHHHCC--------------------------------------- T ss_conf 44503887----79999765873101124567788886303--------------------------------------- Q ss_pred CCCCCCCCHHCCCCCCCCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCC Q ss_conf 54566540000368887622147994079985075225555420577477899999999999987087378845666356 Q Ver_Hs_NP_0061 200 PLTSGSDEENVALPLGDNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKN 279 (492) Q Consensus 200 ~~~s~~de~~v~lPLgeg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kN 279 (492) ...|+++|.+|+|. +.+.++..+.++.||=++++..+.||++...| T Consensus 119 -----------------------~~~~iiivgnK~Dl-----------~~~~~v~~~e~~~~~~~~~~~~~e~Sa~~g~g 164 (179) T 1z0f_A 119 -----------------------PNTVIILIGNKADL-----------EAQRDVTYEEAKQFAEENGLLFLEASAKTGEN 164 (179) T ss_dssp -----------------------TTCEEEEEEECTTC-----------GGGCCSCHHHHHHHHHHTTCEEEECCTTTCTT T ss_pred -----------------------CCCCEEEECCCCCC-----------CCCCCCCHHHHHHHHHHCCCEEEEEECCCCCC T ss_conf -----------------------23220010011111-----------31224388899999996498399996268978 Q ss_pred HHHHHHHHHHHHH Q ss_conf 7999999988872 Q Ver_Hs_NP_0061 280 LDLLYKYIVHKTY 292 (492) Q Consensus 280 l~lLykYi~Hrly 292 (492) ++-+...++++++ T Consensus 165 I~e~f~~l~~~i~ 177 (179) T 1z0f_A 165 VEDAFLEAAKKIY 177 (179) T ss_dssp HHHHHHHHHHHHC T ss_pred HHHHHHHHHHHHH T ss_conf 8899999999996 No 62 >1z0j_A RAB-22, RAS-related protein RAB-22A; RAB GTPase, RAB22 GTPase, endosomal trafficking; HET: GTP; 1.32A {Mus musculus} SCOP: c.37.1.8 Probab=98.82 E-value=1.5e-06 Score=66.56 Aligned_columns=159 Identities=20% Q ss_pred EEEEEECCCCCHHHHHHHHHCCC-CCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEEE Q ss_conf 48886078854899999862013-36787431033530212134730010058856760211353224773433021020 Q Ver_Hs_NP_0061 56 NILVFGEDGSGKTTLMTKLQGAE-HGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLVI 134 (492) Q Consensus 56 nILvLG~~~sGKttLi~~Lq~~e-~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlVv 134 (492) .|+|+|..++||||||.+|.+.+ ...........+..+.-...+...++.+|-..|.-.+..+.+.....-.. ++ T Consensus 8 kI~iiG~~~vGKSsLi~~l~~~~~~~~~~~t~~~~~~~~~~~~~~~~~~~~~~d~~g~~~~~~~~~~~~~~~~~----~i 83 (170) T 1z0j_A 8 KVCLLGDTGVGKSSIMWRFVEDSFDPNINPTIGASFMTKTVQYQNELHKFLIWDTAGLERFRALAPMYYRGSAA----AI 83 (170) T ss_dssp EEEEECCTTSSHHHHHHHHHHSCCCTTCCCCCSEEEEEEEEEETTEEEEEEEEEECCSGGGGGGTHHHHTTCSE----EE T ss_pred EEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCE----EE T ss_conf 88998079987899999986481355523200000111001001403544310266620121210132036650----79 Q ss_pred EHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCCC Q ss_conf 00212032479999999999999999724888899999999999998620350005777767664545665400003688 Q Ver_Hs_NP_0061 135 FVADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPL 214 (492) Q Consensus 135 I~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lPL 214 (492) +|.|.+.+ .-.+.+..|+..++.+...- T Consensus 84 ~v~d~~~~-~s~~~~~~~~~~~~~~~~~~--------------------------------------------------- 111 (170) T 1z0j_A 84 IVYDITKE-ETFSTLKNWVRELRQHGPPS--------------------------------------------------- 111 (170) T ss_dssp EEEETTCH-HHHHHHHHHHHHHHHHSCTT--------------------------------------------------- T ss_pred EEEECCCC-HHHHHHHHHHHHHHCCCCCC--------------------------------------------------- T ss_conf 99743551-13432333432211037998--------------------------------------------------- Q ss_pred CCCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHH Q ss_conf 87622147994079985075225555420577477899999999999987087378845666356799999998887 Q Ver_Hs_NP_0061 215 GDNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKT 291 (492) Q Consensus 215 geg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~Hrl 291 (492) +|+++|++|+|..+ ++...+++ ++.++-++++..+.||++...|++-+...|..++ T Consensus 112 ----------~piilv~nK~Dl~~----~~~~~~~~-------~~~~~~~~~~~~~e~Sa~~~~~i~elf~~i~~~i 167 (170) T 1z0j_A 112 ----------IVVAIAGNKCDLTD----VREVMERD-------AKDYADSIHAIFVETSAKNAININELFIEISRRI 167 (170) T ss_dssp ----------SEEEEEEECTTCGG----GCCSCHHH-------HHHHHHHTTCEEEECBTTTTBSHHHHHHHHHHHC T ss_pred ----------CEEEEEECCCCHHH----HHHHHHHH-------HHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHH T ss_conf ----------46999833430013----32013578-------8999995498599985268978889999999961 No 63 >cd04122 Rab14 Rab14 subfamily. Rab14 GTPases are localized to biosynthetic compartments, including the rough ER, the Golgi complex, and the trans-Golgi network, and to endosomal compartments, including early endosomal vacuoles and associated vesicles. Rab14 is believed to function in both the biosynthetic and recycling pathways between the Golgi and endosomal compartments. Rab14 has also been identified on GLUT4 vesicles, and has been suggested to help regulate GLUT4 translocation. In addition, Rab14 is believed to play a role in the regulation of phagocytosis. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GT Probab=98.80 E-value=4.4e-07 Score=70.01 Aligned_columns=159 Identities=20% Q ss_pred EEEEECCCCCHHHHHHH-HHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEEEE Q ss_conf 88860788548999998-62013367874310335302121347300100588567602113532247734330210200 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTK-LQGAEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLVIF 135 (492) Q Consensus 57 ILvLG~~~sGKttLi~~-Lq~~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlVvI 135 (492) |+|+|+.++|||+|+.+ +++.....-..-++..|....=...+..-++.+|=.-|.-.+.++.+..+.- -..+|| T Consensus 5 ivviGd~~VGKTsli~r~~~~~f~~~~~~Ti~~~~~~k~i~~~~~~v~l~i~Dt~G~e~~~~~~~~~~~~----a~~~il 80 (166) T cd04122 5 YIIIGDMGVGKSCLLHQFTEKKFMADCPHTIGVEFGTRIIEVNGQKIKLQIWDTAGQERFRAVTRSYYRG----AAGALM 80 (166) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEECCEEEEEEEEECCCCHHHHHHHHHHCCC----CCEEEE T ss_conf 9998269955899998876384364456210221467888528908999986358860234553864269----875999 Q ss_pred HHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCCCC Q ss_conf 02120324799999999999999997248888999999999999986203500057777676645456654000036888 Q Ver_Hs_NP_0061 136 VADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLG 215 (492) Q Consensus 136 ~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lPLg 215 (492) |-|.+.+=.+ +.+.+|+.-++.+... T Consensus 81 vydit~~~Sf-~~i~~w~~~~~~~~~~----------------------------------------------------- 106 (166) T cd04122 81 VYDITRRSTY-NHLSSWLTDARNLTNP----------------------------------------------------- 106 (166) T ss_pred EEECCCHHHH-HHHHHHHHHHHHCCCC----------------------------------------------------- T ss_conf 8207998789-9999999999740489----------------------------------------------------- Q ss_pred CCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHH Q ss_conf 76221479940799850752255554205774778999999999999870873788456663567999999988872 Q Ver_Hs_NP_0061 216 DNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTY 292 (492) Q Consensus 216 eg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~Hrly 292 (492) ..|+++|.+|+|. +++.++-..-.+.+|-++|+..+.||+|...|++-+..++.-.+| T Consensus 107 --------~~~iilVGNK~DL-----------~~~r~v~~~e~~~~a~~~~~~~~E~SAk~~~nV~e~F~~l~~~i~ 164 (166) T cd04122 107 --------NTVIFLIGNKADL-----------EAQRDVTYEEAKQFADENGLLFLECSAKTGENVEDAFLETAKKIY 164 (166) T ss_pred --------CCEEEEECCHHHH-----------HHHCCCCHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHH T ss_conf --------9579996372544-----------430354178999999964991999971589887899999999985 No 64 >1vg8_A RAS-related protein RAB-7; GTP-binding protein; HET: GNP; 1.70A {Rattus norvegicus} SCOP: c.37.1.8 Probab=98.80 E-value=1.8e-06 Score=65.87 Aligned_columns=162 Identities=24% Q ss_pred EEEEEECCCCCHHHHHHHHHC---CCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEE Q ss_conf 488860788548999998620---13367874310335302121347300100588567602113532247734330210 Q Ver_Hs_NP_0061 56 NILVFGEDGSGKTTLMTKLQG---AEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETL 132 (492) Q Consensus 56 nILvLG~~~sGKttLi~~Lq~---~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~Tl 132 (492) .|+|+|+.++|||||+.+|.+ .+.....-|.+|.........+ ..++.+|-..|...+..+.+..+.. -.. T Consensus 10 KI~iiG~~~vGKSsLi~~l~~~~~~~~~~~ti~~~~~~~~~~~~~~--~~~~~i~D~~g~~~~~~~~~~~~~~----~~~ 83 (207) T 1vg8_A 10 KVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVDDR--LVTMQIWDTAGQERFQSLGVAFYRG----ADC 83 (207) T ss_dssp EEEEECCTTSSHHHHHHHHHHSCCCSSCCCCCSEEEEEEEEESSSC--EEEEEEEEECSSGGGSCSCCGGGTT----CSE T ss_pred EEEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEECCC--EEEEEEECCCCCCCCCCCCCCCCCC----CCE T ss_conf 9999807998789999998648016752563035789999751276--1555653277643112255310024----211 Q ss_pred EEEHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCC Q ss_conf 20002120324799999999999999997248888999999999999986203500057777676645456654000036 Q Ver_Hs_NP_0061 133 VIFVADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVAL 212 (492) Q Consensus 133 VvI~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~l 212 (492) ++|+.|.+.+..+-. +.+|..-+........ T Consensus 84 ~i~v~d~~~~~s~~~-~~~~~~~~~~~~~~~~------------------------------------------------ 114 (207) T 1vg8_A 84 CVLVFDVTAPNTFKT-LDSWRDEFLIQASPRD------------------------------------------------ 114 (207) T ss_dssp EEEEEETTCHHHHHT-HHHHHHHHHHHHCCSS------------------------------------------------ T ss_pred EEEEEEEECCHHHCC-CHHHHHHHHHHHHHCC------------------------------------------------ T ss_conf 334443200001002-0346899999862116------------------------------------------------ Q ss_pred CCCCCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHH Q ss_conf 88876221479940799850752255554205774778999999999999870873788456663567999999988872 Q Ver_Hs_NP_0061 213 PLGDNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTY 292 (492) Q Consensus 213 PLgeg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~Hrly 292 (492) .-++|+++|.+|+| |..+....++...+.+. .+++..+.||++...|++-+..+|...++ T Consensus 115 ---------~~~~piiiV~nK~D----l~~~~~~~~~~~~~~~~-------~~~~~~~~~Sa~~~~gi~~lf~~l~~~i~ 174 (207) T 1vg8_A 115 ---------PENFPFVVLGNKID----LENRQVATKRAQAWCYS-------KNNIPYFETSAKEAINVEQAFQTIARNAL 174 (207) T ss_dssp ---------GGGSCEEEEEECTT----SSCCCSCHHHHHHHHHH-------TTSCCEEECBTTTTBSHHHHHHHHHHHHH T ss_pred ---------CCCCEEEEEECCCC----CCHHHHHHHHHHHHHHH-------HCCCCEEEEECCCCCCHHHHHHHHHHHHH T ss_conf ---------78841899844645----10111048999999998-------53894477513567788899999999998 No 65 >cd04106 Rab23_lke Rab23-like subfamily. Rab23 is a member of the Rab family of small GTPases. In mouse, Rab23 has been shown to function as a negative regulator in the sonic hedgehog (Shh) signalling pathway. Rab23 mediates the activity of Gli2 and Gli3, transcription factors that regulate Shh signaling in the spinal cord, primarily by preventing Gli2 activation in the absence of Shh ligand. Rab23 also regulates a step in the cytoplasmic signal transduction pathway that mediates the effect of Smoothened (one of two integral membrane proteins that are essential components of the Shh signaling pathway in vertebrates). In humans, Rab23 is expressed in the retina. Mice contain an isoform that shares 93% sequence identity with the human Rab23 and an alternative splicing isoform that is specific to the brain. This isoform causes the murine open brain phenotype, indicating it may have a role in the development of the central nervous system. GTPase activating proteins (GAPs) interact with G Probab=98.80 E-value=3.4e-07 Score=70.79 Aligned_columns=156 Identities=24% Q ss_pred EEEEECCCCCHHHHHHHHHC---CCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEE Q ss_conf 88860788548999998620---133678743103353021213473001005885676021135322477343302102 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTKLQG---AEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLV 133 (492) Q Consensus 57 ILvLG~~~sGKttLi~~Lq~---~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlV 133 (492) |+++|+.++|||+|+.++-. .+.....-|.+|..-.|.-.+++..-++.+|-..|.-.+..+.+....--+ .+ T Consensus 3 i~~iGd~~vGKTsli~r~~~~~f~~~~~~Tig~~~~~k~v~v~~~~~~v~l~iwDt~g~e~~~~~~~~~~~~~~----~~ 78 (162) T cd04106 3 VIVVGNGNVGKSSMIQRFVKGIFTKDYKKTIGVDFLEKQIFLRQSDEDVRLMLWDTAGQEEFDAITKAYYRGAQ----AC 78 (162) T ss_pred EEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEEEECCEEEEEEEECCCCCCHHHHHHHHHCCCCC----EE T ss_conf 89980798448999999862822755564101046777899700884799998718888003455376414897----89 Q ss_pred EEHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCC Q ss_conf 00021203247999999999999999972488889999999999999862035000577776766454566540000368 Q Ver_Hs_NP_0061 134 IFVADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALP 213 (492) Q Consensus 134 vI~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lP 213 (492) +||-|.+.+..+ +.++.|..-+++.... T Consensus 79 llvydvt~~~Sf-~~i~~w~~~i~~~~~~--------------------------------------------------- 106 (162) T cd04106 79 ILVFSTTDRESF-EAIESWKEKVEAECGD--------------------------------------------------- 106 (162) T ss_pred EEEEECCCHHHH-HHHHHHHHHHHHHCCC--------------------------------------------------- T ss_conf 999866997899-9999999999985499--------------------------------------------------- Q ss_pred CCCCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHH Q ss_conf 88762214799407998507522555542057747789999999999998708737884566635679999999888 Q Ver_Hs_NP_0061 214 LGDNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHK 290 (492) Q Consensus 214 Lgeg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~Hr 290 (492) +|+++|-+|+|. .++-.+..+-.+.+|-++|+..+.||+|...|++-+.++|.-+ T Consensus 107 -----------~p~ilVGNK~Dl-----------~~~~~vs~~~~~~~a~~~~~~~~E~SAk~~~nV~e~F~~la~k 161 (162) T cd04106 107 -----------IPMVLVQTKIDL-----------LDQAVITNEEAEALAKRLQLPLFRTSVKDDFNVTELFEYLAEK 161 (162) T ss_pred -----------CEEEEEECCCCC-----------CCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHH T ss_conf -----------379998214232-----------1246589899999999669959999715898878999999850 No 66 >2g3y_A GTP-binding protein GEM; small GTPase, GDP, inactive state, RGK family, structural genomics, structural genomics consortium, SGC; HET: GDP; 2.40A {Homo sapiens} SCOP: c.37.1.8 Probab=98.80 E-value=5.8e-07 Score=69.25 Aligned_columns=180 Identities=21% Q ss_pred HHHHHHHHHHHHHCCCCCCCCCCE--EEEEECCCCCHHHHHHHHHCCCCCCCCC----CCEEEEEECCCCCCCCC-CCCC Q ss_conf 068999999998178622788764--8886078854899999862013367874----31033530212134730-0100 Q Ver_Hs_NP_0061 33 QSLWSSILSEVSTRARSKLPSGKN--ILVFGEDGSGKTTLMTKLQGAEHGKKGR----GLEYLYLSVHDEDRDDH-TRCN 105 (492) Q Consensus 33 ~~lWssil~eV~~~~~~klp~~Kn--ILvLG~~~sGKttLi~~Lq~~e~~kkg~----gLeY~Yl~V~D~drDd~-~R~~ 105 (492) +||-.+..+..+...+ .|-.+- |+|+|+.++|||+|+.+|.+.+...... ..++....+.-+...-. -... T Consensus 16 ~~~~~~~~~~~~~~~~--~~~~~~~KI~lvG~~~vGKSsLi~rl~~~~~~~~~~~~~~~~~~~~~~i~~d~~~~~~~~~~ 93 (211) T 2g3y_A 16 ENLYFQSMSTDSVISS--ESGNTYYRVVLIGEQGVGKSTLANIFAGVHDSMDSDCEVLGEDTYERTLMVDGESATIILLD 93 (211) T ss_dssp ---------------------CCEEEEEEECCTTSSHHHHHHHHHCCCCTTCCC---CCTTEEEEEEEETTEEEEEEEEC T ss_pred CCCEECCCCCCCCCCC--CCCCCEEEEEEECCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEEEECCCEEEEEEEE T ss_conf 4410000122211356--78882589999828986588988777526553254357517888999996348616899861 Q ss_pred EEEECCCCCCCCCCCCCCCCCCHHHEEEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC Q ss_conf 58856760211353224773433021020002120324799999999999999997248888999999999999986203 Q Ver_Hs_NP_0061 106 VWILDGDLYHKGLLKFAVSAESLPETLVIFVADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYM 185 (492) Q Consensus 106 VwiLdg~~~~~~LLk~al~~~si~~TlVvI~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ 185 (492) +|-..|.-.+ ....++..++ .++||.|.+.+.+ ++.+..|..-++ T Consensus 94 i~d~~g~e~~-~~~~~~~~~d-----~~ilvfD~~~~~S-~~~i~~~~~~i~---------------------------- 138 (211) T 2g3y_A 94 MWENKGENEW-LHDHCMQVGD-----AYLIVYSITDRAS-FEKASELRIQLR---------------------------- 138 (211) T ss_dssp CTTTTHHHHH-HHHCCCCCCS-----EEEEEEETTCHHH-HHHHHHHHHHHH---------------------------- T ss_pred CCCCCCCCCC-CCHHHHCCCE-----EEEEEEEEECCCC-CCCCCCCCEEEE---------------------------- T ss_conf 1101100000-1112220340-----3443443210454-232212310000---------------------------- Q ss_pred CCHHCCCCCCCCCCCCCCCCCCHHCCCCCCCCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHC Q ss_conf 50005777767664545665400003688876221479940799850752255554205774778999999999999870 Q Ver_Hs_NP_0061 186 EPEEGCQGSPQRRGPLTSGSDEENVALPLGDNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQY 265 (492) Q Consensus 186 ep~~~~~gs~~r~~~~~s~~de~~v~lPLgeg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~Y 265 (492) ....+..+|++||.+|+|..+ ......++. +.|+-.+ T Consensus 139 --------------------------------~~~~~~~~piiivgnK~Dl~~----~~~i~~~e~-------~~~~~~~ 175 (211) T 2g3y_A 139 --------------------------------RARQTEDIPIILVGNKSDLVR----CREVSVSEG-------RACAVVF 175 (211) T ss_dssp --------------------------------TSGGGTTSCEEEEEECTTCGG----GCCSCHHHH-------HHHHHHH T ss_pred --------------------------------ECCCCCCEEEEEEECCCCCCC----CCCCCHHHH-------HHHHHHC T ss_conf --------------------------------013445168999702578001----046788999-------9999964 Q ss_pred CCEEEEECCCCCCCHHHHHHHHHHHHH Q ss_conf 873788456663567999999988872 Q Ver_Hs_NP_0061 266 GAALIYTSVKEEKNLDLLYKYIVHKTY 292 (492) Q Consensus 266 GAsLiYTS~ke~kNl~lLykYi~Hrly 292 (492) ++..+.||++...|++-+...+++.++ T Consensus 176 ~~~~~e~SAk~g~gI~elf~~i~~~i~ 202 (211) T 2g3y_A 176 DCKFIETSAAVQHNVKELFEGIVRQVR 202 (211) T ss_dssp TCEEEECBTTTTBSHHHHHHHHHHHHH T ss_pred CCCEEEEECCCCCCHHHHHHHHHHHHH T ss_conf 993899970488688899999999998 No 67 >2rex_B RHO-related GTP-binding protein RHO6; complex, structural genomics consortium, SGC, GTPase, GNP, plexin, effector domain, alternative splicing; HET: GNP; 2.30A {Homo sapiens} Probab=98.79 E-value=4.5e-07 Score=69.95 Aligned_columns=170 Identities=21% Q ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEEEEH Q ss_conf 88860788548999998620133678743103353021213473001005885676021135322477343302102000 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTKLQGAEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLVIFV 136 (492) Q Consensus 57 ILvLG~~~sGKttLi~~Lq~~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlVvI~ 136 (492) |+|+|+.++|||+||.++...+-.......-...+.+.-...+..-++.+|-..|...+..+.+..+.- -..+||| T Consensus 13 i~vvG~~~vGKTsli~~~~~~~~~~~~~~t~~~~~~~~~~~~~~~~~l~iwD~~g~~~~~~~~~~~~~~----~~~~i~v 88 (197) T 2rex_B 13 LVLVGDVQCGKTAMLQVLAKDCYPETYVPTVFENYTACLETEEQRVELSLWDTSGSPYYDNVRPLCYSD----SDAVLLC 88 (197) T ss_dssp EEEECSTTSSHHHHHHHHHHSCCCCSCCCCSEEEEEEEE---CCCEEEEEEEECCSGGGTTTGGGGGTT----CSEEEEE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEEECEEEEEEEECCCCCCCCCCCCCCCCCC----EEEEEEE T ss_conf 999816998789999998617557653432777567752320214577641131211222123000101----1235763 Q ss_pred HHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCCCCC Q ss_conf 21203247999999999999999972488889999999999999862035000577776766454566540000368887 Q Ver_Hs_NP_0061 137 ADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLGD 216 (492) Q Consensus 137 lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lPLge 216 (492) .|++.+=++-.-++.|...++++-.. T Consensus 89 ~d~~~~~S~~~~~~~~~~~~~~~~~~------------------------------------------------------ 114 (197) T 2rex_B 89 FDISRPETVDSALKKWRTEILDYCPS------------------------------------------------------ 114 (197) T ss_dssp EETTCTTTC--CHHHHHHHHHHHCTT------------------------------------------------------ T ss_pred ECCCHHHHHHHHHHHHHHHHHHHCCC------------------------------------------------------ T ss_conf 04560678999998877767761799------------------------------------------------------ Q ss_pred CCEECCCCCEEEEEEECCCH----------HHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEE-ECCCCC-CCHHHHH Q ss_conf 62214799407998507522----------55554205774778999999999999870873788-456663-5679999 Q Ver_Hs_NP_0061 217 NVLTHNLGIPVLVVCTKCDA----------VSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIY-TSVKEE-KNLDLLY 284 (492) Q Consensus 217 g~Lt~NLGiPi~VVctKsD~----------ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiY-TS~ke~-kNl~lLy 284 (492) +|+++|++|+|. ...-++.-++.+ .+.+|-++|+..+| ||++.. .|++-+. T Consensus 115 --------~~iilVgnK~DL~~~~~~~~~~~~~~~~~is~~e---------~~~~a~~~~~~~y~E~Sakt~~~~v~~~f 177 (197) T 2rex_B 115 --------TRVLLIGCKTDLRTDLSTLMELSHQKQAPISYEQ---------GCAIAKQLGAEIYLEGSAFTSEKSIHSIF 177 (197) T ss_dssp --------SEEEEEEECGGGGGCHHHHHHHHHTTCCCCCHHH---------HHHHHHHTTCSCEEECBTTTBHHHHHHHH T ss_pred --------CEEEEEECCCCCCCCHHHHHHHHHHHCCCCCHHH---------HHHHHHHCCCCEEEEEEECCCCHHHHHHH T ss_conf --------4799950456863211355665554204678899---------99999965995899875234661279999 Q ss_pred HHHHHHHHCCCCCCCCE Q ss_conf 99988872777676550 Q Ver_Hs_NP_0061 285 KYIVHKTYGFHFTTPAL 301 (492) Q Consensus 285 kYi~Hrlygfpf~~ka~ 301 (492) +.+...+.+=|...|.. T Consensus 178 ~~~~~~~~~~~~~~p~~ 194 (197) T 2rex_B 178 RTASMLCLNKPSPLPQK 194 (197) T ss_dssp HHHHHHHC--------- T ss_pred HHHHHHHHCCCCCCCCC T ss_conf 99999996287888867 No 68 >e2ew1a1 c.37.1.8 (A:4-174) Rab30 {Human (Homo sapiens) [TaxID:9606]} Probab=98.79 E-value=5.3e-07 Score=69.53 Aligned_columns=160 Identities=19% Q ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCC-CCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEEEE Q ss_conf 8886078854899999862013367874-310335302121347300100588567602113532247734330210200 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTKLQGAEHGKKGR-GLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLVIF 135 (492) Q Consensus 57 ILvLG~~~sGKttLi~~Lq~~e~~kkg~-gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlVvI 135 (492) |+|+|+.++|||||+.+|.+......-. ..+..+....-.-.+....+.+|...|...+....+..+.--. .+++ T Consensus 8 i~ivG~~~vGKTsLi~~l~~~~~~~~~~~t~~~~~~~~~~~~~~~~~~~~~~d~~g~~~~~~~~~~~~~~~~----~~i~ 83 (171) T e2ew1a1 8 IVLIGNAGVGKTCLVRRFTQGLFPPGQGATIGVDFMIKTVEINGEKVKLQIWDTAGQERFRSITQSYYRSAN----ALIL 83 (171) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEECCCCEEEEEEEECCCCCCCCCCCCHHHCCCC----EEEE T ss_conf 999826998799999998648246665404787777678730893135888605884100001201203787----2799 Q ss_pred HHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCCCC Q ss_conf 02120324799999999999999997248888999999999999986203500057777676645456654000036888 Q Ver_Hs_NP_0061 136 VADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLG 215 (492) Q Consensus 136 ~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lPLg 215 (492) +.|.+.+.+ ++.+..|...+...... T Consensus 84 v~d~~~~~s-~~~~~~~~~~~~~~~~~----------------------------------------------------- 109 (171) T e2ew1a1 84 TYDITCEES-FRCLPEWLREIEQYASN----------------------------------------------------- 109 (171) T ss_pred EEECCCCCC-HHHHHHHHHHHHHHCCC----------------------------------------------------- T ss_conf 874123120-25688889999863268----------------------------------------------------- Q ss_pred CCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHC Q ss_conf 762214799407998507522555542057747789999999999998708737884566635679999999888727 Q Ver_Hs_NP_0061 216 DNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTYG 293 (492) Q Consensus 216 eg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~Hrlyg 293 (492) .+|+++|++|+|. .++-++..+.++.||-.++...+.||++...|++-+...|.-++.. T Consensus 110 --------~~~iilv~nK~Dl-----------~~~~~i~~~e~~~~~~~~~~~~~e~Saktg~gI~elf~~i~~~i~~ 168 (171) T e2ew1a1 110 --------KVITVLVGNKIDL-----------AERREVSQQRAEEFSEAQDMYYLETSAKESDNVEKLFLDLACRLIS 168 (171) T ss_pred --------CCEEEEEEECCCC-----------CCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHH T ss_conf --------7037999723454-----------4455669899999999649839999715898888999999999998 No 69 >cd04115 Rab33B_Rab33A Rab33B/Rab33A subfamily. Rab33B is ubiquitously expressed in mouse tissues and cells, where it is localized to the medial Golgi cisternae. It colocalizes with alpha-mannose II. Together with the other cisternal Rabs, Rab6A and Rab6A', it is believed to regulate the Golgi response to stress and is likely a molecular target in stress-activated signaling pathways. Rab33A (previously known as S10) is expressed primarily in the brain and immune system cells. In humans, it is located on the X chromosome at Xq26 and its expression is down-regulated in tuberculosis patients. Experimental evidence suggests that Rab33A is a novel CD8+ T cell factor that likely plays a role in tuberculosis disease processes. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine Probab=98.78 E-value=5.7e-07 Score=69.28 Aligned_columns=157 Identities=30% Q ss_pred EEEEECCCCCHHHHHHHHHC---CCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCC-CCCCCCCCCCCCHHHEE Q ss_conf 88860788548999998620---133678743103353021213473001005885676021-13532247734330210 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTKLQG---AEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYH-KGLLKFAVSAESLPETL 132 (492) Q Consensus 57 ILvLG~~~sGKttLi~~Lq~---~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~-~~LLk~al~~~si~~Tl 132 (492) |+++|+.++|||+|+.++.. .+.....-|.+|....+.=+ +...++.+|=-.|.-.+ .+|.+....--+ . T Consensus 5 ivliGd~~VGKTsli~r~~~~~F~~~~~~Tig~d~~~k~i~~~--~~~v~l~iwDtaGqe~f~~~l~~~y~~~a~----~ 78 (170) T cd04115 5 IIVIGDSNVGKTCLTYRFCAGRFPERTEATIGVDFRERTVEID--GERIKVQLWDTAGQERFRKSMVQHYYRNVH----A 78 (170) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEEEC--CEEEEEEEECCCCCHHHHHHHHHHHCCCCC----E T ss_conf 9998079965899999986285575445312203578999988--958999982278733567777654304898----4 Q ss_pred EEEHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCC Q ss_conf 20002120324799999999999999997248888999999999999986203500057777676645456654000036 Q Ver_Hs_NP_0061 133 VIFVADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVAL 212 (492) Q Consensus 133 VvI~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~l 212 (492) ++|+-|.+.+.++-. |..|+.-++ T Consensus 79 ~ilvydit~~~SF~~-i~~w~~~i~------------------------------------------------------- 102 (170) T cd04115 79 VVFVYDVTNMASFHS-LPSWIEECE------------------------------------------------------- 102 (170) T ss_pred EEEEEECCCHHHHHH-HHHHHHHHH------------------------------------------------------- T ss_conf 899987699778899-999999999------------------------------------------------------- Q ss_pred CCCCCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCC---CCCCHHHHHHHHHH Q ss_conf 888762214799407998507522555542057747789999999999998708737884566---63567999999988 Q Ver_Hs_NP_0061 213 PLGDNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVK---EEKNLDLLYKYIVH 289 (492) Q Consensus 213 PLgeg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~k---e~kNl~lLykYi~H 289 (492) .-..+-.+|+++|++|+|. .++..+-..-.+.+|-++|+..|-||+| +..|++.+...|.. T Consensus 103 -----~~~~~~~~p~iLVGNK~DL-----------~~~r~Vs~~e~~~~A~~~~~~~fE~SAK~~~~~~nV~~~F~~la~ 166 (170) T cd04115 103 -----QHSLPNEVPRILVGNKCDL-----------REQIQVPTDLAQRFADAHSMPLFETSAKDPSENDHVEAIFMTLAH 166 (170) T ss_pred -----HHCCCCCCEEEEEECCCCC-----------HHHCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHH T ss_conf -----7259986179998021350-----------121367989999999966995999862678888687899999999 Q ss_pred HH Q ss_conf 87 Q Ver_Hs_NP_0061 290 KT 291 (492) Q Consensus 290 rl 291 (492) +| T Consensus 167 ~l 168 (170) T cd04115 167 KL 168 (170) T ss_pred HH T ss_conf 96 No 70 >d1m7ba_ c.37.1.8 (A:) RhoE (RND3) {Mouse (Mus musculus)} SCOP: d1gwnc_ Probab=98.78 E-value=8.8e-07 Score=68.02 Aligned_columns=162 Identities=22% Q ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEEEEH Q ss_conf 88860788548999998620133678743103353021213473001005885676021135322477343302102000 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTKLQGAEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLVIFV 136 (492) Q Consensus 57 ILvLG~~~sGKttLi~~Lq~~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlVvI~ 136 (492) |+++|+.++|||+|+.++.+.+........-...+...-...+..-++.+|-..|...+..+.+..+.--+ .+++| T Consensus 5 I~iiG~~~vGKSsli~~~~~~~f~~~~~~ti~~~~~~~~~~~~~~~~~~i~Dt~g~~~~~~~~~~~~~~~d----~~ilv 80 (179) T d1m7ba_ 5 IVVVGDSQCGKTALLHVFAKDCFPENYVPTVFENYTASFEIDTQRIELSLWDTSGSPYYDNVRPLSYPDSD----AVLIC 80 (179) T ss_dssp EEEEESTTSSHHHHHHHHHHSCCCSSCCCCSEEEEEEEEECSSCEEEEEEEEECCSGGGTTTGGGGCTTCS----EEEEE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEECCEEEEEEEEECCCCCCCCCCCHHHHCCCC----EEEEE T ss_conf 99970799878999999862842676244068888886551556899998713551100312203331787----69999 Q ss_pred HHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCCCCC Q ss_conf 21203247999999999999999972488889999999999999862035000577776766454566540000368887 Q Ver_Hs_NP_0061 137 ADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLGD 216 (492) Q Consensus 137 lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lPLge 216 (492) .|++.+..+-.-++.|...++..... T Consensus 81 ~d~~~~~S~~~~~~~~~~~~~~~~~~------------------------------------------------------ 106 (179) T d1m7ba_ 81 FDISRPETLDSVLKKWKGEIQEFCPN------------------------------------------------------ 106 (179) T ss_dssp EETTCHHHHHHHHHTHHHHHHHHCTT------------------------------------------------------ T ss_pred EECCCHHHHHHHHHHHHHHHHHHCCC------------------------------------------------------ T ss_conf 86376146888853348999973487------------------------------------------------------ Q ss_pred CCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHH-----HHHHHHHHHHHHCCCEEEE-ECCCCCCC-HHHHHHHHH Q ss_conf 622147994079985075225555420577477899-----9999999999870873788-45666356-799999998 Q Ver_Hs_NP_0061 217 NVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLD-----FIQSHLRRFCLQYGAALIY-TSVKEEKN-LDLLYKYIV 288 (492) Q Consensus 217 g~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD-----~Iqq~LR~~cL~YGAsLiY-TS~ke~kN-l~lLykYi~ 288 (492) +|+++|++|+|..+ +.....+.++ +-..-.+.+|-++|+-.+| ||++...| ++-+.+.++ T Consensus 107 --------~piilVgnK~DL~~----~~~~~~~~~~~~~~~Vs~~e~~~la~~~~~~~y~E~SA~~~~n~v~~vF~~~~ 173 (179) T d1m7ba_ 107 --------TKMLLVGCKSDLRT----DVSTLVELSNHRQTPVSYDQGANMAKQIGAATYIECSALQSENSVRDIFHVAT 173 (179) T ss_dssp --------CEEEEEEECGGGGG----CHHHHHHHHTTTCCCCCHHHHHHHHHHHTCSEEEECBTTTBHHHHHHHHHHHH T ss_pred --------CCEEEEECCCCCCC----CHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHH T ss_conf --------50465641555443----11356655420377479899999999718943898740368741899999999 No 71 >cd04109 Rab28 Rab28 subfamily. First identified in maize, Rab28 has been shown to be a late embryogenesis-abundant (Lea) protein that is regulated by the plant hormone abcisic acid (ABA). In Arabidopsis, Rab28 is expressed during embryo development and is generally restricted to provascular tissues in mature embryos. Unlike maize Rab28, it is not ABA-inducible. Characterization of the human Rab28 homolog revealed two isoforms, which differ by a 95-base pair insertion, producing an alternative sequence for the 30 amino acids at the C-terminus. The two human isoforms are presumbly the result of alternative splicing. Since they differ at the C-terminus but not in the GTP-binding region, they are predicted to be targeted to different cellular locations. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs Probab=98.78 E-value=6.3e-07 Score=68.98 Aligned_columns=170 Identities=25% Q ss_pred EEEEECCCCCHHHHHHHHHC---CCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEE Q ss_conf 88860788548999998620---133678743103353021213473001005885676021135322477343302102 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTKLQG---AEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLV 133 (492) Q Consensus 57 ILvLG~~~sGKttLi~~Lq~---~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlV 133 (492) |+++|+.++|||+|+.+... .+.+...-|++|.-..+. -+.+...++.+|-..|.-.+..+......--+ .+ T Consensus 3 VvliGd~~VGKTSLi~rf~~~~F~~~y~~Tig~d~~~k~i~-i~~~~~v~l~iwDtaGqe~~~~~~~~y~~~a~----~~ 77 (215) T cd04109 3 IVVLGDGAVGKTSLCRRFAKEGFGKSYKQTIGLDFFSKRVT-LPGNLNVTLQVWDIGGQSIGGKMLDKYIYGAH----AV 77 (215) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEE-ECCCCEEEEEEEECCCCCHHHHHHHHHHCCCC----EE T ss_conf 89982698538999988770721776465145678789999-75860589999864773023688998705998----48 Q ss_pred EEHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCC Q ss_conf 00021203247999999999999999972488889999999999999862035000577776766454566540000368 Q Ver_Hs_NP_0061 134 IFVADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALP 213 (492) Q Consensus 134 vI~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lP 213 (492) +|+-|.+.+ .=.+.|+.|...++ T Consensus 78 ilVYdIt~~-~SF~~i~~W~~~i~-------------------------------------------------------- 100 (215) T cd04109 78 FLVYDVTNS-QSFENLEDWYSMVR-------------------------------------------------------- 100 (215) T ss_pred EEEEECCCH-HHHHHHHHHHHHHH-------------------------------------------------------- T ss_conf 999753897-68999999999999-------------------------------------------------------- Q ss_pred CCCCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHC Q ss_conf 88762214799407998507522555542057747789999999999998708737884566635679999999888727 Q Ver_Hs_NP_0061 214 LGDNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTYG 293 (492) Q Consensus 214 Lgeg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~Hrlyg 293 (492) +..-...-..+|++|-.|+|. +++..+-..-.+.||-++|+..|.||+|...|++.|++.|.-+++| T Consensus 101 --~~~~~~~~~~~iiLVGNK~DL-----------~~~R~Vs~ee~~~~A~~~~~~f~EvSAktg~nV~elF~~la~~i~~ 167 (215) T cd04109 101 --KVLKSSETQPLVVLVGNKTDL-----------EHNRTVKDDKHARFAQANGMESCLVSAKTGDRVNLLFQQLAAELLG 167 (215) T ss_pred --HHHHCCCCCCEEEEECCCCCH-----------HHCCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHC T ss_conf --873105898189996054240-----------1206679899999999649959999626798888999999999808 Q ss_pred CCCCCCCE Q ss_conf 77676550 Q Ver_Hs_NP_0061 294 FHFTTPAL 301 (492) Q Consensus 294 fpf~~ka~ 301 (492) ..-+.++. T Consensus 168 ~~~~~~~~ 175 (215) T cd04109 168 VDLSKAEL 175 (215) T ss_pred CCCCHHHC T ss_conf 63110104 No 72 >cd04124 RabL2 RabL2 subfamily. RabL2 (Rab-like2) subfamily. RabL2s are novel Rab proteins identified recently which display features that are distinct from other Rabs, and have been termed Rab-like. RabL2 contains RabL2a and RabL2b, two very similar Rab proteins that share 98% sequence identity in humans. RabL2b maps to the subtelomeric region of chromosome 22q13.3 and RabL2a maps to 2q13, a region that suggests it is also a subtelomeric gene. Both genes are believed to be expressed ubiquitously, suggesting that RabL2s are the first example of duplicated genes in human proximal subtelomeric regions that are both expressed actively. Like other Rab-like proteins, RabL2s lack a prenylation site at the C-terminus. The specific functions of RabL2a and RabL2b remain unknown. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-b Probab=98.78 E-value=9.7e-07 Score=67.75 Aligned_columns=157 Identities=25% Q ss_pred EEEEECCCCCHHHHHHH-HHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEEEE Q ss_conf 88860788548999998-62013367874310335302121347300100588567602113532247734330210200 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTK-LQGAEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLVIF 135 (492) Q Consensus 57 ILvLG~~~sGKttLi~~-Lq~~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlVvI 135 (492) |+++|+.++|||+|+.+ +.+...+....-.+-.+....-.-.+....+.+|=..|.-.+.++......- --.++| T Consensus 3 iiliGd~~VGKTsli~r~~~~~f~~~~~~t~~~~~~~k~~~~~~~~v~l~iwDt~G~e~~~~~~~~~~~~----a~~~il 78 (161) T cd04124 3 IILLGDSAVGKSKLVERFLMDGYEPQQLSTYALTLYKHNAKFEGKTILVDFWDTAGQERFQTMHASYYHK----AHACIL 78 (161) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEECCEEEEEEEEECCCCCHHHHHHHHHCCC----CCEEEE T ss_conf 8998069944889887865386376623532567899999998869999997457841103566743024----785899 Q ss_pred HHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCCCC Q ss_conf 02120324799999999999999997248888999999999999986203500057777676645456654000036888 Q Ver_Hs_NP_0061 136 VADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLG 215 (492) Q Consensus 136 ~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lPLg 215 (492) |-|.+.+.++ +.|+.|+.-++++-.. T Consensus 79 vfDit~~~Sf-~~l~~W~~~i~~~~~~----------------------------------------------------- 104 (161) T cd04124 79 VFDVTRKITY-KNLSKWYEELREYRPE----------------------------------------------------- 104 (161) T ss_pred EEECCCHHHH-HHHHHHHHHHHHHCCC----------------------------------------------------- T ss_conf 9866996688-9999999999984699----------------------------------------------------- Q ss_pred CCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHCC Q ss_conf 7622147994079985075225555420577477899999999999987087378845666356799999998887277 Q Ver_Hs_NP_0061 216 DNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTYGF 294 (492) Q Consensus 216 eg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~Hrlygf 294 (492) +|+++|.+|+| |+.+ +.+--+.++-+++...|+||+|...|++-+.+-++-....+ T Consensus 105 ---------~p~ilVGNK~D----l~~~----------~~~~~~~~a~~~~~~~fetSAk~g~nV~e~F~~~~~~~i~~ 160 (161) T cd04124 105 ---------IPCIVVANKID----LDPS----------VTQKKFNFAEKHNLPLYYVSAADGTNVVKLFQDAIKLAVSY 160 (161) T ss_pred ---------CEEEEEECCCC----CCHH----------HHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHC T ss_conf ---------37999823765----6435----------68999999996599199997268988789999999999834 No 73 >1u8z_A RAS-related protein RAL-A; GNP, GTP, GMPPNP, GPPNHP, GDP, GTPase; HET: GDP; 1.50A {Saguinus oedipus} SCOP: c.37.1.8 Probab=98.77 E-value=2.6e-07 Score=71.53 Aligned_columns=160 Identities=15% Q ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEEEEH Q ss_conf 88860788548999998620133678743103353021213473001005885676021135322477343302102000 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTKLQGAEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLVIFV 136 (492) Q Consensus 57 ILvLG~~~sGKttLi~~Lq~~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlVvI~ 136 (492) |+|+|+.++||||||.+|.+.+-...-....-..+...-...+..-++.+|-..|...+..+.+.....-.. +++| T Consensus 7 I~iiG~~~vGKTsLi~~~~~~~~~~~~~~t~~~~~~~~~~~~~~~~~l~i~d~~g~~~~~~~~~~~~~~~~~----~i~v 82 (168) T 1u8z_A 7 VIMVGSGGVGKSALTLQFMYDEFVEDYEPTKADSYRKKVVLDGEEVQIDILDTAGQEDYAAIRDNYFRSGEG----FLCV 82 (168) T ss_dssp EEEECSTTSSHHHHHHHHHHSCCCSCCCTTCCEEEEEEEEETTEEEEEEEEECCC---CHHHHHHHHHHCSE----EEEE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEECCCEEECCCCCEEEEEECCCCCCCHHHCCCCCCCHHCCHH----EEEH T ss_conf 899827997789999998638447653432010101002566624642002345601112223100001000----0001 Q ss_pred HHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCCCCC Q ss_conf 21203247999999999999999972488889999999999999862035000577776766454566540000368887 Q Ver_Hs_NP_0061 137 ADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLGD 216 (492) Q Consensus 137 lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lPLge 216 (492) .|.+.+..+ +.+..|...+. T Consensus 83 ~d~~~~~s~-~~~~~~~~~~~----------------------------------------------------------- 102 (168) T 1u8z_A 83 FSITEMESF-AATADFREQIL----------------------------------------------------------- 102 (168) T ss_dssp EETTCHHHH-HHHHHHHHHHH----------------------------------------------------------- T ss_pred HHHHCCCCH-HHHHHHHHHHH----------------------------------------------------------- T ss_conf 111100325-78999997543----------------------------------------------------------- Q ss_pred CCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHH Q ss_conf 6221479940799850752255554205774778999999999999870873788456663567999999988872 Q Ver_Hs_NP_0061 217 NVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTY 292 (492) Q Consensus 217 g~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~Hrly 292 (492) ....+..+|++||++|+|. .++-.+-.+-++.++-++|+..+.||++...|++-+..+|+..+. T Consensus 103 -~~~~~~~~piiiv~nK~Dl-----------~~~~~v~~~~~~~~~~~~~~~~~e~Sa~~~~gi~e~f~~i~~~i~ 166 (168) T 1u8z_A 103 -RVKEDENVPFLLVGNKSDL-----------EDKRQVSVEEAKNRADQWNVNYVETSAKTRANVDKVFFDLMREIR 166 (168) T ss_dssp -HHHCCTTSCEEEEEECGGG-----------GGGCCSCHHHHHHHHHHHTCEEEECCTTTCTTHHHHHHHHHHHHH T ss_pred -HCCCCCCCEEEEECCCHHH-----------HHHCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHH T ss_conf -2037998379971452012-----------331154378999999965995899861688788899999999997 No 74 >d1ek0a_ c.37.1.8 (A:) Ypt51 {Baker's yeast (Saccharomyces cerevisiae)} Probab=98.77 E-value=1.2e-06 Score=67.18 Aligned_columns=160 Identities=23% Q ss_pred EEEEEECCCCCHHHHHHHHHC---CCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEE Q ss_conf 488860788548999998620---13367874310335302121347300100588567602113532247734330210 Q Ver_Hs_NP_0061 56 NILVFGEDGSGKTTLMTKLQG---AEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETL 132 (492) Q Consensus 56 nILvLG~~~sGKttLi~~Lq~---~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~Tl 132 (492) .|+++|+.++|||||+.+|.+ .+....+-+.+|....+ +..+...++.+|-..|.-.+..+.+..+..-.+ T Consensus 5 Ki~ivG~~~vGKTsli~~l~~~~~~~~~~~t~~~~~~~~~i--~~~~~~~~~~i~D~~g~~~~~~~~~~~~~~~d~---- 78 (170) T d1ek0a_ 5 KLVLLGEAAVGKSSIVLRFVSNDFAENKEPTIGAAFLTQRV--TINEHTVKFEIWDTAGQERFASLAPXYYRNAQA---- 78 (170) T ss_dssp EEEEECSTTSSHHHHHHHHHHSCCCTTCCCCSSEEEEEEEE--EETTEEEEEEEEEECCSGGGGGGHHHHHTTCSE---- T ss_pred EEEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEE--EECCEEEEEEEECCCCCHHHHHHHHHHHCCCCC---- T ss_conf 89998079987999999986483357635315533567789--998968999872266822455552544035784---- Q ss_pred EEEHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCC Q ss_conf 20002120324799999999999999997248888999999999999986203500057777676645456654000036 Q Ver_Hs_NP_0061 133 VIFVADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVAL 212 (492) Q Consensus 133 VvI~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~l 212 (492) +++|.|++.|..+ +++..|...++.....- T Consensus 79 ~i~v~d~~~~~s~-~~~~~~~~~i~~~~~~~------------------------------------------------- 108 (170) T d1ek0a_ 79 ALVVYDVTKPQSF-IKARHWVKELHEQASKD------------------------------------------------- 108 (170) T ss_dssp EEEEEETTCHHHH-HHHHHHHHHHHHHSCTT------------------------------------------------- T ss_pred EEEEEEECCCHHH-HHHHHHHHHHHHHHCCC------------------------------------------------- T ss_conf 1899974161236-78999999998642158------------------------------------------------- Q ss_pred CCCCCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHH Q ss_conf 8887622147994079985075225555420577477899999999999987087378845666356799999998887 Q Ver_Hs_NP_0061 213 PLGDNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKT 291 (492) Q Consensus 213 PLgeg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~Hrl 291 (492) .|+++|.+|+|..+...+..--.+ .++.++-.+++..+.||++...|++-+..-|..++ T Consensus 109 ------------~~~iiv~nK~D~~~~~~~~~i~~~--------~~~~~~~~~~~~~~e~Sa~~~~gi~e~f~~i~~~i 167 (170) T d1ek0a_ 109 ------------IIIALVGNKIDXLQEGGERKVARE--------EGEKLAEEKGLLFFETSAKTGENVNDVFLGIGEKI 167 (170) T ss_dssp ------------CEEEEEEECGGGGGSSCCCCSCHH--------HHHHHHHHHTCEEEECCTTTCTTHHHHHHHHHTTS T ss_pred ------------CCEEEEECCCCCCCCCCCCCCCHH--------HHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHC T ss_conf ------------727999717552111565421778--------99999995598499986268978889999999855 No 75 >d1kmqa_ c.37.1.8 (A:) RhoA {Human (Homo sapiens)} SCOP: d1cc0a_ d1ow3b_ d1xcgb_ d1ftn__ d1x86b_ d1s1ca_ d1lb1b_ d1tx4b_ d1cxza_ d1a2b__ u1z2ca1 d1dpfa_ u2fv8a1 Probab=98.77 E-value=1.4e-06 Score=66.65 Aligned_columns=164 Identities=16% Q ss_pred CEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEEE Q ss_conf 64888607885489999986201336787431033530212134730010058856760211353224773433021020 Q Ver_Hs_NP_0061 55 KNILVFGEDGSGKTTLMTKLQGAEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLVI 134 (492) Q Consensus 55 KnILvLG~~~sGKttLi~~Lq~~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlVv 134 (492) |-|+|+|+.++|||+|+.++.+.+....-.......+...-...+..-++.+|-..|...+..+.+..+..-++ ++ T Consensus 3 ~KI~iiG~~~vGKTsli~~~~~~~~~~~~~~t~~~~~~~~~~~~~~~~~~~i~D~~g~~~~~~~~~~~~~~~~~----~i 78 (177) T d1kmqa_ 3 KKLVIVGDGACGKTCLLIVNSKDQFPEVYVPTVFENYVADIEVDGKQVELALWDTAGLEDYDRLRPLSYPDTDV----IL 78 (177) T ss_dssp EEEEEEESTTSSHHHHHHHHHHSCCCSSCCCCSEEEEEEEEEETTEEEEEEEEEECCSGGGTTTGGGGCTTCSE----EE T ss_pred EEEEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEECCCEEEEEEEECCCCCCCCCCHHHHCCCCEE----EE T ss_conf 58999826998799999998627436652330443368898765916888887515510012110000102203----56 Q ss_pred EHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCCC Q ss_conf 00212032479999999999999999724888899999999999998620350005777767664545665400003688 Q Ver_Hs_NP_0061 135 FVADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPL 214 (492) Q Consensus 135 I~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lPL 214 (492) +|.|.+.|++|..-...|...++....+ T Consensus 79 lv~d~~~~~s~~~~~~~~~~~~~~~~~~---------------------------------------------------- 106 (177) T d1kmqa_ 79 MCFSIDSPDSLENIPEKWTPEVKHFCPN---------------------------------------------------- 106 (177) T ss_dssp EEEETTCHHHHHHHHHTHHHHHHHHSTT---------------------------------------------------- T ss_pred EEEECCCHHHHHHHHHHHHHHHHHHCCC---------------------------------------------------- T ss_conf 7630460678998876578999851565---------------------------------------------------- Q ss_pred CCCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHH-----HHHHHHHHHHHCCCEEEE-ECCCCCCCHHHHHHHHH Q ss_conf 876221479940799850752255554205774778999-----999999999870873788-45666356799999998 Q Ver_Hs_NP_0061 215 GDNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDF-----IQSHLRRFCLQYGAALIY-TSVKEEKNLDLLYKYIV 288 (492) Q Consensus 215 geg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~-----Iqq~LR~~cL~YGAsLiY-TS~ke~kNl~lLykYi~ 288 (492) +|++||++|+|..+ +....++.... -+.....++-+++.-.+| ||++...|++-+...++ T Consensus 107 ----------~piiivgnK~Dl~~----~~~~~~~~~~~~~~~v~~~~~~~~a~~~~~~~~~e~Saktg~gi~e~fe~i~ 172 (177) T d1kmqa_ 107 ----------VPIILVGNKKDLRN----DEHTRRELAKMKQEPVKPEEGRDMANRIGAFGYMECSAKTKDGVREVFEMAT 172 (177) T ss_dssp ----------SCEEEEEECGGGTT----CHHHHHHHHHTTCCCCCHHHHHHHHHHTTCSEEEECCTTTCTTHHHHHHHHH T ss_pred ----------CEEEEEEECCCCCC----CCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHH T ss_conf ----------23688751346554----3025688887640278989999999972893389975058878889999999 No 76 >2ce2_X GTPase HRAS; guanine nucleotide binding protein, fluorescence, membrane, signaling protein, disease mutation, golgi stack, GTP- binding; HET: GDP XY2; 1.0A {Homo sapiens} Probab=98.77 E-value=1.4e-06 Score=66.60 Aligned_columns=158 Identities=18% Q ss_pred EEEEECCCCCHHHHHHHHHCCC-CCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEEEE Q ss_conf 8886078854899999862013-367874310335302121347300100588567602113532247734330210200 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTKLQGAE-HGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLVIF 135 (492) Q Consensus 57 ILvLG~~~sGKttLi~~Lq~~e-~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlVvI 135 (492) |+++|+.++||||||.++.+.+ ........+..|.....-+ +..-+..+|-..|.-.+..+.+.....-.+ +++ T Consensus 6 i~iiG~~~vGKTsll~~~~~~~~~~~~~~t~~~~~~~~~~~~-~~~~~~~~~d~~g~~~~~~~~~~~~~~~~~----~i~ 80 (166) T 2ce2_X 6 LVVVGAGGVGKSALTIQLIQNHFVDECDPTIEDSYRKQVVID-GETCLLDILDTAGQEEYSAMRDQYMRTGEG----FLC 80 (166) T ss_dssp EEEEESTTSSHHHHHHHHHHSSCCSCCCTTCCEEEEEEEEET-TEEEEEEEEECCCCSSCCHHHHHHHHHCSE----EEE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEC-CEEEEEEEECCCCCCCCCCCCCHHHHHHEE----EEE T ss_conf 899807998789999998638325553430000256778643-435531244046764332111001110001----110 Q ss_pred HHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCCCC Q ss_conf 02120324799999999999999997248888999999999999986203500057777676645456654000036888 Q Ver_Hs_NP_0061 136 VADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLG 215 (492) Q Consensus 136 ~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lPLg 215 (492) |.|.+++.++-+ +.+|..-++......+ T Consensus 81 v~d~~~~~s~~~-~~~~~~~i~~~~~~~~--------------------------------------------------- 108 (166) T 2ce2_X 81 VFAINNTKSFED-IHQYREQIKRVKDSDD--------------------------------------------------- 108 (166) T ss_dssp EEETTCHHHHHH-HHHHHHHHHHHHTCSC--------------------------------------------------- T ss_pred EEECCCHHHHHH-HHHHHHHHHHHCCCCC--------------------------------------------------- T ss_conf 121341122344-4456655553027898--------------------------------------------------- Q ss_pred CCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHH Q ss_conf 76221479940799850752255554205774778999999999999870873788456663567999999988872 Q Ver_Hs_NP_0061 216 DNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTY 292 (492) Q Consensus 216 eg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~Hrly 292 (492) +|+++|.+|+|.. +..-..++. +.++-.++...+.||++...|++-+...|...++ T Consensus 109 ---------~piiiv~nK~Dl~-----~~~~~~~~~-------~~~~~~~~~~~~e~Sak~~~gi~e~f~~i~~~i~ 164 (166) T 2ce2_X 109 ---------VPMVLVGNKSDLA-----ARTVESRQA-------QDLARSYGIPYIETSAKTRQGVEDAFYTLVREIR 164 (166) T ss_dssp ---------CCEEEEEECTTCS-----CCCSCHHHH-------HHHHHHHTCCEEEECTTTCTTHHHHHHHHHHHHH T ss_pred ---------CEEEEEECCCCHH-----HCCCHHHHH-------HHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHH T ss_conf ---------4899950254501-----103407899-------9999964981899862688687899999999997 No 77 >cd04108 Rab36_Rab34 Rab34/Rab36 subfamily. Rab34, found primarily in the Golgi, interacts with its effector, Rab-interacting lysosomal protein (RILP). This enables its participation in microtubular dynenin-dynactin-mediated repositioning of lysosomes from the cell periphery to the Golgi. A Rab34 (Rah) isoform that lacks the consensus GTP-binding region has been identified in mice. This isoform is associated with membrane ruffles and promotes macropinosome formation. Rab36 has been mapped to human chromosome 22q11.2, a region that is homozygously deleted in malignant rhabdoid tumors (MRTs). However, experimental assessments do not implicate Rab36 as a tumor suppressor that would enable tumor formation through a loss-of-function mechanism. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further re Probab=98.76 E-value=5.5e-07 Score=69.38 Aligned_columns=161 Identities=19% Q ss_pred EEEEECCCCCHHHHHHHHHC---CCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEE Q ss_conf 88860788548999998620---133678743103353021213473001005885676021135322477343302102 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTKLQG---AEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLV 133 (492) Q Consensus 57 ILvLG~~~sGKttLi~~Lq~---~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlV 133 (492) |+++|+.++|||+|+.++.. .++....-|.+|.-..+.-...+ ..+.+|=..|.-.+.++.+....--+. + T Consensus 3 ivliGd~~VGKTsli~rf~~~~f~~~y~~Tig~d~~~k~~~~~~~~--i~l~iwDtaG~e~~~~~~~~~~~~a~~----~ 76 (170) T cd04108 3 VIVVGDLSVGKTCLINRFCKDVFDKNYKATIGVDFEMERFEILGVP--FSLQLWDTAGQERFKCIASTYYRGAQA----I 76 (170) T ss_pred EEEEECCCCCHHHHHHHHHCCEECCCCCCEEEEEEEEEEEEECCEE--EEEEEEECCCCHHHHHHHHHHCCCCCE----E T ss_conf 8998169854899888876282278624425667889987518837--999985368860245666754048880----8 Q ss_pred EEHHHHCCHHHHHHHHHHHH-HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCC Q ss_conf 00021203247999999999-99999997248888999999999999986203500057777676645456654000036 Q Ver_Hs_NP_0061 134 IFVADMSRPWTVMESLQKWA-SVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVAL 212 (492) Q Consensus 134 vI~lD~s~PW~~m~qL~~Wi-~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~l 212 (492) |||-|.+.+.++ +++++|+ ++++.+-.+ T Consensus 77 ilvyDit~~~Sf-~~~~~w~~~~~~~~~~~-------------------------------------------------- 105 (170) T cd04108 77 IIVFDLTDVASL-EHTRQWLEDALKENDPS-------------------------------------------------- 105 (170) T ss_pred EEEEECCCHHHH-HHHHHHHHHHHHHHCCC-------------------------------------------------- T ss_conf 999754986578-99999999998740799-------------------------------------------------- Q ss_pred CCCCCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHH Q ss_conf 88876221479940799850752255554205774778999999999999870873788456663567999999988872 Q Ver_Hs_NP_0061 213 PLGDNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTY 292 (492) Q Consensus 213 PLgeg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~Hrly 292 (492) .+|+++|.+|+|..+ .++..++.+.-+.++-++|+..|.||+|...|++-+.+.|.-.+| T Consensus 106 -----------~~~i~LVGnK~DL~~---------~~~~~~~~~~~~~~a~~~~~~~fEtSAktg~nV~e~F~~ia~~~~ 165 (170) T cd04108 106 -----------SVLLFLVGTKKDLSS---------PAQYALMEQDAIKLAAEMQAEYWSVSALSGENVREFFFRVAALTF 165 (170) T ss_pred -----------CCEEEEEECCCCCCC---------CCCCEECHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHH T ss_conf -----------968999835601045---------311200378999999965995999972588787899999999998 Q ss_pred CC Q ss_conf 77 Q Ver_Hs_NP_0061 293 GF 294 (492) Q Consensus 293 gf 294 (492) .+ T Consensus 166 ~~ 167 (170) T cd04108 166 EL 167 (170) T ss_pred HC T ss_conf 50 No 78 >PF00071 Ras: Ras family; InterPro: IPR013753 Many members of the Ras superfamily of GTPases have been implicated in the regulation of hematopoietic cells, with roles in growth, survival, differentiation, cytokine production, chemotaxis, vesicle-trafficking, and phagocytosis. The Ras superfamily of proteins now includes over 150 small GTPases (distinguished from the large, heterotrimeric GTPases, the G-proteins). It comprises six subfamilies, the Ras, Rho, Ran, Rab, Arf, and Kir/Rem/Rad subfamilies . They exhibit remarkable overall amino acid identities, especially in the regions interacting with the guanine nucleotide exchange factors that catalyze their activation . ; PDB: 2fol_A 1ukv_Y 1yzn_A 2bcg_Y 1g17_B 1g16_C 3rab_A 1zbd_A 2ew1_A 1x3s_A .... Probab=98.76 E-value=1.5e-06 Score=66.56 Aligned_columns=160 Identities=28% Q ss_pred EEEEECCCCCHHHHHHHHHC---CCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCC-CCCCCCCCCHHHEE Q ss_conf 88860788548999998620---133678743103353021213473001005885676021135-32247734330210 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTKLQG---AEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGL-LKFAVSAESLPETL 132 (492) Q Consensus 57 ILvLG~~~sGKttLi~~Lq~---~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~L-Lk~al~~~si~~Tl 132 (492) |+++|+.++|||+|+.++-. .+.....-|.++....+.-. +..-++.+|=.-|.-.+.+| -.+.-++ -. T Consensus 2 iiliG~~~vGKTsl~~r~~~~~f~~~y~~TiG~d~~~~~i~~~--~~~v~l~iwDTaGqe~f~~l~~~~~~~a-----~~ 74 (174) T PF00071_consen 2 IILIGDSGVGKTSLIKRFVEGEFIESYTPTIGVDFYSKTIQID--GKSVKLQIWDTAGQERFRSLRSSYYRNA-----DG 74 (174) T ss_dssp EEEEESTTSSHHHHHHHHHHSSSSSSCETSSSEEEEEEEEEET--TEEEEEEEEEETSSGGGHHHHHHHHTTE-----SE T ss_pred EEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCC--CCEEEEEEEEEECCCCCCCCCHHHEEEE-----EE T ss_conf 7888089853334200121134411122444401223200267--7347898873102310012200110011-----24 Q ss_pred EEEHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCC Q ss_conf 20002120324799999999999999997248888999999999999986203500057777676645456654000036 Q Ver_Hs_NP_0061 133 VIFVADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVAL 212 (492) Q Consensus 133 VvI~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~l 212 (492) +|||-|++.+ .-.+.|.+|+.-++.+.. T Consensus 75 ~ilvydit~~-~Sf~~i~~w~~~i~~~~~--------------------------------------------------- 102 (174) T PF00071_consen 75 VILVYDITNR-ESFENIKKWIEEIKKIAP--------------------------------------------------- 102 (174) T ss_dssp EEEEEETTHH-HHHHHHHHHHHHHHHHST--------------------------------------------------- T ss_pred EEEEEEEECC-CEEHHHHHHHHHHCCCCC--------------------------------------------------- T ss_conf 6678753001-100001222232002556--------------------------------------------------- Q ss_pred CCCCCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHH-------HHHHHHHHHHHHHHHCC-CEEEEECCCCCCCHHHHH Q ss_conf 8887622147994079985075225555420577477-------89999999999998708-737884566635679999 Q Ver_Hs_NP_0061 213 PLGDNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDE-------HLDFIQSHLRRFCLQYG-AALIYTSVKEEKNLDLLY 284 (492) Q Consensus 213 PLgeg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE-------~fD~Iqq~LR~~cL~YG-AsLiYTS~ke~kNl~lLy 284 (492) ..-.+|+++|.+|+|..+ |+ +-.+-....+.+|-++| ...|-||++...|++-+. T Consensus 103 --------~~~~~~iiLVGnK~DL~~---------~~~~~~~~~~r~V~~~e~~~~a~~~~~~~~~EtSAk~~~ni~~~F 165 (174) T PF00071_consen 103 --------KDENIPIILVGNKSDLKE---------EESTELENKQRQVSTEEAQQLAKKLGAIKFFETSAKTGENIEELF 165 (174) T ss_dssp --------SSTTSEEEEEEETTCGGG---------CHHHHHCTSGSSSHHHHHHHHHHHTTSSEEEEEBTTTTTTHHHHH T ss_pred --------CCCHHHEEEEECCCCCCC---------CCHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHH T ss_conf --------320011001110354433---------100100022102455778899987338741686446787878999 Q ss_pred HHHHHHHH Q ss_conf 99988872 Q Ver_Hs_NP_0061 285 KYIVHKTY 292 (492) Q Consensus 285 kYi~Hrly 292 (492) ..+...++ T Consensus 166 ~~l~~~i~ 173 (174) T PF00071_consen 166 QTLIKQIL 173 (174) T ss_dssp HHHHHHHH T ss_pred HHHHHHHH T ss_conf 99999983 No 79 >2fv8_A H6, RHO-related GTP-binding protein RHOB; GDP/GTP binding, GTP hydrolysis, structural genomics, structural genomics consortium, SGC; HET: GDP; 1.90A {Homo sapiens} SCOP: c.37.1.8 Probab=98.76 E-value=1.3e-06 Score=67.00 Aligned_columns=166 Identities=17% Q ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEEEEH Q ss_conf 88860788548999998620133678743103353021213473001005885676021135322477343302102000 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTKLQGAEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLVIFV 136 (492) Q Consensus 57 ILvLG~~~sGKttLi~~Lq~~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlVvI~ 136 (492) |+|+|+.++||||||.+|.+..-...-...--..+...=...+..-.+.+|-..|...+..+.+..+.. -..+++| T Consensus 28 I~iiG~~~vGKSSLi~~l~~~~~~~~~~~T~~~~~~~~i~~~~~~~~l~i~D~~g~~~~~~~~~~~~~~----~~~~ilv 103 (207) T 2fv8_A 28 LVVVGDGACGKTCLLIVFSKDEFPEVYVPTVFENYVADIEVDGKQVELALWDTAGQEDYDRLRPLSYPD----TDVILMC 103 (207) T ss_dssp EEEEECTTSSHHHHHHHHHHSSCC-------CCEEEEEEEETTEEEEEEEEECTTCTTCTTTGGGGCTT----CCEEEEE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEEEEEEEEEECCCCCCCHHHHHHHHHHHHH----HHHHHHE T ss_conf 668816997799999998617457544532552048999872055643004553201222456775446----4510000 Q ss_pred HHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCCCCC Q ss_conf 21203247999999999999999972488889999999999999862035000577776766454566540000368887 Q Ver_Hs_NP_0061 137 ADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLGD 216 (492) Q Consensus 137 lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lPLge 216 (492) .|.+.++++-+-.+.|+..++.+-... T Consensus 104 ~d~~~~~Sf~~i~~~~~~~~~~~~~~~----------------------------------------------------- 130 (207) T 2fv8_A 104 FSVDSPDSLENIPEKWVPEVKHFCPNV----------------------------------------------------- 130 (207) T ss_dssp EETTCHHHHHHHHHTHHHHHHHHSTTC----------------------------------------------------- T ss_pred ECCCHHHHHHHHHHHHHHHHHHHCCCE----------------------------------------------------- T ss_conf 114406789998887789986307963----------------------------------------------------- Q ss_pred CCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHH-----HHHHHHHHHHHHCCC-EEEEECCCCCCCHHHHHHHHHHH Q ss_conf 622147994079985075225555420577477899-----999999999987087-37884566635679999999888 Q Ver_Hs_NP_0061 217 NVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLD-----FIQSHLRRFCLQYGA-ALIYTSVKEEKNLDLLYKYIVHK 290 (492) Q Consensus 217 g~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD-----~Iqq~LR~~cL~YGA-sLiYTS~ke~kNl~lLykYi~Hr 290 (492) |+++|++|+|... ++...++... +...-.++++-+++. ..|.||++...|++-+..+++.. T Consensus 131 ---------piilVgnK~Dl~~----~~~v~~~~~~~~~~~i~~~~~~~~~~~~~~~~~~e~Sa~~~~gi~e~f~~i~~~ 197 (207) T 2fv8_A 131 ---------PIILVANKKDLRS----DEHVRTELARMKQEPVRTDDGRAMAVRIQAYDYLECSAKTKEGVREVFETATRA 197 (207) T ss_dssp ---------CEEEEEECGGGGG----CHHHHHHHHHTTCCCCCHHHHHHHHHHTTCSEEEECCTTTCTTHHHHHHHHHHH T ss_pred ---------EEEECCCCCCCCC----HHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHH T ss_conf ---------8997115877530----124558899875122567899999997089518997516886778999999999 Q ss_pred HH Q ss_conf 72 Q Ver_Hs_NP_0061 291 TY 292 (492) Q Consensus 291 ly 292 (492) ++ T Consensus 198 ~l 199 (207) T 2fv8_A 198 AL 199 (207) T ss_dssp HH T ss_pred HH T ss_conf 99 No 80 >d1c1ya_ c.37.1.8 (A:) Rap1A {Human (Homo sapiens)} SCOP: d1guaa_ Probab=98.75 E-value=2.3e-06 Score=65.24 Aligned_columns=160 Identities=19% Q ss_pred EEEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEEEE Q ss_conf 48886078854899999862013367874310335302121347300100588567602113532247734330210200 Q Ver_Hs_NP_0061 56 NILVFGEDGSGKTTLMTKLQGAEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLVIF 135 (492) Q Consensus 56 nILvLG~~~sGKttLi~~Lq~~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlVvI 135 (492) .|+|+|+.++|||||+.++...+....-...-...+...=...+....+.+|-..|...+..+.+.....-. .|++ T Consensus 5 kI~viG~~~vGKTsLi~~~~~~~~~~~~~~t~~~~~~~~~~~~~~~~~~~~~D~~g~~~~~~~~~~~~~~~~----~vil 80 (167) T d1c1ya_ 5 KLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDCQQCMLEILDTAGTEQFTAMRDLYMKNGQ----GFAL 80 (167) T ss_dssp EEEEECSTTSSHHHHHHHHHHCCCCCSCCCCSEEEEEEEEESSSCEEEEEEEEECSSCSSTTHHHHHHHHCS----EEEE T ss_pred EEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEECCEEEEEEEEECCCCCCHHHHHHHHCCCCC----EEEE T ss_conf 899980799878999999862821665466322036899987361356788723786411355576404886----8999 Q ss_pred HHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCCCC Q ss_conf 02120324799999999999999997248888999999999999986203500057777676645456654000036888 Q Ver_Hs_NP_0061 136 VADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLG 215 (492) Q Consensus 136 ~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lPLg 215 (492) |.|.+.++++ +.+..|..-+..+... T Consensus 81 v~D~~~~~s~-~~~~~~~~~~~~~~~~----------------------------------------------------- 106 (167) T d1c1ya_ 81 VYSITAQSTF-NDLQDLREQILRVKDT----------------------------------------------------- 106 (167) T ss_dssp EEETTCHHHH-HTHHHHHHHHHHHHCC----------------------------------------------------- T ss_pred EEECCCCCCH-HHHHHHHHHHHHHCCC----------------------------------------------------- T ss_conf 8216877557-8899999889874078----------------------------------------------------- Q ss_pred CCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEE-ECCCCCCCHHHHHHHHHHHH Q ss_conf 76221479940799850752255554205774778999999999999870873788-45666356799999998887 Q Ver_Hs_NP_0061 216 DNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIY-TSVKEEKNLDLLYKYIVHKT 291 (492) Q Consensus 216 eg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiY-TS~ke~kNl~lLykYi~Hrl 291 (492) -++|+++|++|+| |.+++.-..|+ .+.+.-++++..+| ||++...|++-|...|+-.+ T Consensus 107 -------~~~piiivgnK~D----l~~~~~v~~~~-------~~~~~~~~~~~~~~e~Sa~~g~gi~elf~~l~~~I 165 (167) T d1c1ya_ 107 -------EDVPMILVGNKCD----LEDERVVGKEQ-------GQNLARQWCNCAFLESSAKSKINVNEIFYDLVRQI 165 (167) T ss_dssp -------SCCCEEEEEECTT----CGGGCCSCHHH-------HHHHHHHTTSCEEEECBTTTTBSHHHHHHHHHHHH T ss_pred -------CCCEEEEEEECCC----CCCCCCCCHHH-------HHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHH T ss_conf -------9817999840468----52224679899-------99999983697189975158978889999999996 No 81 >2a9k_A RAS-related protein RAL-A; bacterial ADP-ribosyltransferase, RAL, RHO, GDP-binding; HET: GDP NAD; 1.73A {Homo sapiens} SCOP: c.37.1.8 Probab=98.75 E-value=1.3e-06 Score=66.79 Aligned_columns=179 Identities=16% Q ss_pred HHHHHHHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCC Q ss_conf 99999998178622788764888607885489999986201336787431033530212134730010058856760211 Q Ver_Hs_NP_0061 37 SSILSEVSTRARSKLPSGKNILVFGEDGSGKTTLMTKLQGAEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHK 116 (492) Q Consensus 37 ssil~eV~~~~~~klp~~KnILvLG~~~sGKttLi~~Lq~~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~ 116 (492) |-..+...-.+.+.++- .-|+++|+.++|||||+.+|.+-+.........-..+...-...+..-.+.+|-..|.--+. T Consensus 2 ~~~~~~~~~~~~~~~~~-~KI~ivG~~~vGKTsLl~~l~~~~~~~~~~~T~~~~~~~~~~~~~~~~~l~i~d~~g~~~~~ 80 (187) T 2a9k_A 2 SPGISGGGGGSQNSLAL-HKVIMVGSGGVGKSALTLQFMYDEFVEDYEPTKADSYRKKVVLDGEEVQIDILDTAGQEDYA 80 (187) T ss_dssp ---------------CE-EEEEEECSTTSSHHHHHHHHHHSCCCCSCCTTCCEEEEEEEEETTEEEEEEEEECCCTTCCH T ss_pred CCCCCCCCCCCCCCCCE-EEEEEEECCCCCHHHHHHHHHHCCCCCCCCCEEEEEEEEEEEECCEEEEEEEECCCCCCHHC T ss_conf 88765222467677424-78999827998789999998706447863540664357887626646766662024720001 Q ss_pred CCCCCCCCCCCHHHEEEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCC Q ss_conf 35322477343302102000212032479999999999999999724888899999999999998620350005777767 Q Ver_Hs_NP_0061 117 GLLKFAVSAESLPETLVIFVADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQ 196 (492) Q Consensus 117 ~LLk~al~~~si~~TlVvI~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~ 196 (492) .+.+..+..-.. +++|.|.+.+.++-. +..|...+. T Consensus 81 ~~~~~~~~~~d~----~i~v~d~~~~~s~~~-~~~~~~~~~--------------------------------------- 116 (187) T 2a9k_A 81 AIRDNYFRSGEG----FLCVFSITEMESFAA-TADFREQIL--------------------------------------- 116 (187) T ss_dssp HHHHHHHHHCSE----EEEEEETTCHHHHHH-HHHHHHHHH--------------------------------------- T ss_pred CCCCCCCCCCCE----EEEEECCCCCHHHHH-HHHHHHHHH--------------------------------------- T ss_conf 010001235515----777521654002688-987642110--------------------------------------- Q ss_pred CCCCCCCCCCCHHCCCCCCCCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCC Q ss_conf 66454566540000368887622147994079985075225555420577477899999999999987087378845666 Q Ver_Hs_NP_0061 197 RRGPLTSGSDEENVALPLGDNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKE 276 (492) Q Consensus 197 r~~~~~s~~de~~v~lPLgeg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke 276 (492) ....+-.+|++||++|+| |+.+.....++. +.||-.++..+|.||++. T Consensus 117 ---------------------~~~~~~~~piiiv~nK~D----l~~~~~i~~~~~-------~~~~~~~~~~~~e~Sak~ 164 (187) T 2a9k_A 117 ---------------------RVKEDENVPFLLVGNKSD----LEDKRQVSVEEA-------KNRAEQWNVNYVETSAKT 164 (187) T ss_dssp ---------------------HHHCCTTCCEEEEEECGG----GGGGCCSCHHHH-------HHHHHHTTCEEEECCTTT T ss_pred ---------------------CCCCCCCCEEEEECCCCC----CCCCCCCCHHHH-------HHHHHHCCCCEEEEECCC T ss_conf ---------------------025799727997347654----100156788999-------999996599389996168 Q ss_pred CCCHHHHHHHHHHHHH Q ss_conf 3567999999988872 Q Ver_Hs_NP_0061 277 EKNLDLLYKYIVHKTY 292 (492) Q Consensus 277 ~kNl~lLykYi~Hrly 292 (492) ..+++-+..+++..++ T Consensus 165 g~gi~e~f~~l~~~i~ 180 (187) T 2a9k_A 165 RANVDKVFFDLMREIR 180 (187) T ss_dssp CTTHHHHHHHHHHHHH T ss_pred CCCHHHHHHHHHHHHH T ss_conf 8788899999999999 No 82 >2gco_A H9, RHO-related GTP-binding protein RHOC; GTPase,signaling protein; HET: GNP; 1.40A {Homo sapiens} Probab=98.75 E-value=5.3e-07 Score=69.52 Aligned_columns=182 Identities=14% Q ss_pred HCCCCCCCCCCE-------EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCC Q ss_conf 178622788764-------8886078854899999862013367874310335302121347300100588567602113 Q Ver_Hs_NP_0061 45 TRARSKLPSGKN-------ILVFGEDGSGKTTLMTKLQGAEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKG 117 (492) Q Consensus 45 ~~~~~klp~~Kn-------ILvLG~~~sGKttLi~~Lq~~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~ 117 (492) .++.+-.|+++. |+|+|+.++|||+||.+|.+.+-..+........+...=...+..-.+.+|-..|...+.. T Consensus 9 ~~~~~~~~~~~~~~~~~~KI~viG~~~vGKTSLi~~~~~~~~~~~~~~T~~~~~~~~i~~~~~~~~l~i~D~~g~~~~~~ 88 (201) T 2gco_A 9 HHSSGLVPRGSHMAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYIADIEVDGKQVELALWDTAGQEDYDR 88 (201) T ss_dssp CCCTTCCC-----CCEEEEEEEEESTTSSHHHHHHHHHHSSCCSSCCCSSCCCCEEEEEETTEEEEEEEECCCCSGGGTT T ss_pred CCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEECCEEEEEECCCCCCHHHHHH T ss_conf 11235687644521104237888079975889888776171266525504678899998723788652056652023300 Q ss_pred CCCCCCCCCCHHHEEEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCC Q ss_conf 53224773433021020002120324799999999999999997248888999999999999986203500057777676 Q Ver_Hs_NP_0061 118 LLKFAVSAESLPETLVIFVADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQR 197 (492) Q Consensus 118 LLk~al~~~si~~TlVvI~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r 197 (492) +.......-.. +++|.|.+.+..+..-.+.|...++..-.++ T Consensus 89 ~~~~~~~~~~~----~ilvfdi~~~~S~~~i~~~~~~~~~~~~~~~---------------------------------- 130 (201) T 2gco_A 89 LRPLSYPDTDV----ILMCFSIDSPDSLENIPEKWTPEVKHFCPNV---------------------------------- 130 (201) T ss_dssp TGGGGCTTCSE----EEEEEETTCHHHHHHHHHTHHHHHHHHSTTC---------------------------------- T ss_pred HHHHHHCCCHH----EEEEEECCHHHHHHHHHHHHHHHHHHCCCCC---------------------------------- T ss_conf 00133211000----0023304213679999998765443238994---------------------------------- Q ss_pred CCCCCCCCCCHHCCCCCCCCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHH-HHHHHHHHHHCCC-EEEEECCC Q ss_conf 645456654000036888762214799407998507522555542057747789999-9999999987087-37884566 Q Ver_Hs_NP_0061 198 RGPLTSGSDEENVALPLGDNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFI-QSHLRRFCLQYGA-ALIYTSVK 275 (492) Q Consensus 198 ~~~~~s~~de~~v~lPLgeg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~I-qq~LR~~cL~YGA-sLiYTS~k 275 (492) |+++|++|+|..+.-+..+...++....| .+-.+.+|-+++. ..+.||++ T Consensus 131 ----------------------------piilVgnK~Dl~~~~~~~~~~~~~~~~~i~~~~~~~~~~~~~~~~~~e~Sa~ 182 (201) T 2gco_A 131 ----------------------------PIILVGNKKDLRQDEHTRRELAKMKQEPVRSEEGRDMANRISAFGYLECSAK 182 (201) T ss_dssp ----------------------------CEEEEEECGGGTTCHHHHHHHHTTTCCCCCHHHHHHHHHHTTCSEEEECCTT T ss_pred ----------------------------EEEEEECCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEEC T ss_conf ----------------------------7999752644344410367888764034526899999997089428998605 Q ss_pred CCCCHHHHHHHHHHHHH Q ss_conf 63567999999988872 Q Ver_Hs_NP_0061 276 EEKNLDLLYKYIVHKTY 292 (492) Q Consensus 276 e~kNl~lLykYi~Hrly 292 (492) ...|++-++++++...+ T Consensus 183 ~~~~I~e~F~~i~k~al 199 (201) T 2gco_A 183 TKEGVREVFEMATRAGL 199 (201) T ss_dssp TCTTHHHHHHHHHHHHH T ss_pred CCCCHHHHHHHHHHHHH T ss_conf 88788899999999985 No 83 >1zbd_A Rabphilin-3A; G protein, effector, RABCDR, synaptic exocytosis, RAB protein, RAB3A; HET: GTP; 2.60A {Rattus norvegicus} SCOP: c.37.1.8 Probab=98.75 E-value=2.6e-06 Score=64.89 Aligned_columns=157 Identities=18% Q ss_pred EEEEECCCCCHHHHHHHHHC---CCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEE Q ss_conf 88860788548999998620---133678743103353021213473001005885676021135322477343302102 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTKLQG---AEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLV 133 (492) Q Consensus 57 ILvLG~~~sGKttLi~~Lq~---~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlV 133 (492) |+|+|..++|||||+.+|.+ .+......+.++....+...+. ...+.+|-..|.-.+..+....... --.+ T Consensus 11 i~ivG~~~vGKTsLi~~l~~~~~~~~~~~t~~~~~~~~~~~~~~~--~~~~~i~D~~g~~~~~~~~~~~~~~----~~~~ 84 (203) T 1zbd_A 11 ILIIGNSSVGKTSFLFRYADDSFTPAFVSTVGIDFKVKTIYRNDK--RIKLQIWDTAGLERYRTITTAYYRG----AMGF 84 (203) T ss_dssp EEEECSTTSSHHHHHHHHHTCCCCSCCCCCCSEEEEEEEEEETTE--EEEEEEEEECCSGGGHHHHHTTGGG----CSEE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCC--CCCEEEECCCCCHHHHHHHHHHCCC----CCEE T ss_conf 778817998799999998648215541242123334310211122--5622463167752678899875037----7368 Q ss_pred EEHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCC Q ss_conf 00021203247999999999999999972488889999999999999862035000577776766454566540000368 Q Ver_Hs_NP_0061 134 IFVADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALP 213 (492) Q Consensus 134 vI~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lP 213 (492) ++|.|.+.+ .-.+.+..|...++.+.. T Consensus 85 i~v~d~~~~-~s~~~~~~~~~~~~~~~~---------------------------------------------------- 111 (203) T 1zbd_A 85 ILMYDITNE-ESFNAVQDWSTQIKTYSW---------------------------------------------------- 111 (203) T ss_dssp EEEEETTCH-HHHHHHHHHHHHHHHHSC---------------------------------------------------- T ss_pred EEEEECCCC-CHHHHHHHHHHHHHHCCC---------------------------------------------------- T ss_conf 999854772-013455443333210114---------------------------------------------------- Q ss_pred CCCCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHH Q ss_conf 8876221479940799850752255554205774778999999999999870873788456663567999999988872 Q Ver_Hs_NP_0061 214 LGDNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTY 292 (492) Q Consensus 214 Lgeg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~Hrly 292 (492) ..+|++||++|+| |..++.-..++. +.|+-.|+...|.||++...|++-++..|++.++ T Consensus 112 ---------~~~piivvgnK~D----l~~~~~v~~~~~-------~~~~~~~~~~~~e~Sa~~g~gi~~~f~~l~~~i~ 170 (203) T 1zbd_A 112 ---------DNAQVLLVGNKCD----MEDERVVSSERG-------RQLADHLGFEFFEASAKDNINVKQTFERLVDVIC 170 (203) T ss_dssp ---------SSCEEEEEEECTT----CTTSCCSCHHHH-------HHHHHHHTCEEEECBTTTTBSSHHHHHHHHHHHH T ss_pred ---------CEEEEEEECCCCH----HHHHHCCHHHHH-------HHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHH T ss_conf ---------4058986114420----222211026778-------8999862982899961689788899999999999 No 84 >e2atva1 c.37.1.8 (A:5-172) Ras-like estrogen-regulated growth inhibitor, RERG {Human (Homo sapiens) [TaxID:9606]} Probab=98.74 E-value=1.7e-06 Score=66.15 Aligned_columns=160 Identities=17% Q ss_pred EEEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEEEE Q ss_conf 48886078854899999862013367874310335302121347300100588567602113532247734330210200 Q Ver_Hs_NP_0061 56 NILVFGEDGSGKTTLMTKLQGAEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLVIF 135 (492) Q Consensus 56 nILvLG~~~sGKttLi~~Lq~~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlVvI 135 (492) .|+|+|+.++|||||+.++.+..-.......-..-+...-...+..-.+.+|-..|.-.+.....+..++. .++| T Consensus 4 KI~iiG~~~vGKSsli~~~~~~~~~~~~~~t~~~~~~~~~~~~~~~~~~~i~d~~g~~~~~~~~~~~~~~d-----~~il 78 (168) T e2atva1 4 KLAIFGRAGVGKSALVVRFLTKRFIWEYDPTLESTYRHQATIDDEVVSMEILDTAGQEDTIQREGHMRWGE-----GFVL 78 (168) T ss_pred EEEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEECCEEEEEEEEEECCCHHHHHHHHHHCCCC-----EEEE T ss_conf 89998079987999999986381167625623666789997569079999986206304666665411782-----7999 Q ss_pred HHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCCCC Q ss_conf 02120324799999999999999997248888999999999999986203500057777676645456654000036888 Q Ver_Hs_NP_0061 136 VADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLG 215 (492) Q Consensus 136 ~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lPLg 215 (492) |.|.+.| .-.+.+..|...+. T Consensus 79 v~d~~~~-~S~~~~~~~~~~i~---------------------------------------------------------- 99 (168) T e2atva1 79 VYDITDR-GSFEEVLPLKNILD---------------------------------------------------------- 99 (168) T ss_pred EEEECCC-CCHHHHHHHHHHHH---------------------------------------------------------- T ss_conf 9864485-65668889999988---------------------------------------------------------- Q ss_pred CCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCC-CHHHHHHHHHHHHH Q ss_conf 762214799407998507522555542057747789999999999998708737884566635-67999999988872 Q Ver_Hs_NP_0061 216 DNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEK-NLDLLYKYIVHKTY 292 (492) Q Consensus 216 eg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~k-Nl~lLykYi~Hrly 292 (492) .....-.+|++||++|+| |+.+.....++. +.||-+++...+.||++... |++-+...|+..++ T Consensus 100 --~~~~~~~~piiivgnK~D----l~~~~~i~~~e~-------~~~~~~~~~~~~e~Sa~~g~gnv~e~f~~l~~~i~ 164 (168) T e2atva1 100 --EIKKPKNVTLILVGNKAD----LDHSRQVSTEEG-------EKLATELACAFYECSACTGEGNITEIFYELCREVR 164 (168) T ss_pred --HHCCCCCCEEEEEEECCC----CCCCCCCCHHHH-------HHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHH T ss_conf --631899978999971356----443466798999-------99999649949999722598367899999999998 No 85 >2nzj_A GTP-binding protein REM 1; GDP/GTP binding, GTP hydrolysis, RAD and GEM like GTP binding protein 1, structural genomics; HET: GDP; 2.50A {Homo sapiens} Probab=98.73 E-value=5.3e-07 Score=69.53 Aligned_columns=159 Identities=19% Q ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCC---CCCCCCCCHHHEEE Q ss_conf 888607885489999986201336787431033530212134730010058856760211353---22477343302102 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTKLQGAEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLL---KFAVSAESLPETLV 133 (492) Q Consensus 57 ILvLG~~~sGKttLi~~Lq~~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LL---k~al~~~si~~TlV 133 (492) |+|+|+.++|||+|+.+|.+......-......+....-...+..-++.+|-..|...+.... .+..++ -.+ T Consensus 7 i~ivG~~~vGKSsLi~~~~~~~~~~~~~t~~~~~~~~~i~~~~~~~~~~i~Dt~g~~~~~~~~~~~~~~~~~-----d~~ 81 (175) T 2nzj_A 7 VVLLGDPGVGKTSLASLFAGKQERDLHEQLGEDVYERTLTVDGEDTTLVVVDTWEAEKLDKSWSQESCLQGG-----SAY 81 (175) T ss_dssp EEEECCTTSSHHHHHHHHHCC-----CCCSSSSEEEEEEEETTEEEEEEEECCC-------CHHHHHTTTSC-----SEE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHH-----HHH T ss_conf 989827998799999998557246653760443453003446536777762122101343443335654322-----454 Q ss_pred EEHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCC Q ss_conf 00021203247999999999999999972488889999999999999862035000577776766454566540000368 Q Ver_Hs_NP_0061 134 IFVADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALP 213 (492) Q Consensus 134 vI~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lP 213 (492) ++|.|.+.|..+ +.+.+|..-+. T Consensus 82 ilv~d~~~~~s~-~~~~~~~~~~~-------------------------------------------------------- 104 (175) T 2nzj_A 82 VIVYSIADRGSF-ESASELRIQLR-------------------------------------------------------- 104 (175) T ss_dssp EEEEETTCHHHH-HHHHHHHHHHH-------------------------------------------------------- T ss_pred HHHHHCCCCCCC-HHHHHHHHHHH-------------------------------------------------------- T ss_conf 444311123430-03567778876-------------------------------------------------------- Q ss_pred CCCCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHH Q ss_conf 8876221479940799850752255554205774778999999999999870873788456663567999999988872 Q Ver_Hs_NP_0061 214 LGDNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTY 292 (492) Q Consensus 214 Lgeg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~Hrly 292 (492) .....-++|++||.+|+|. .+.-.+..+-.+.||.+||...+.||++...|++-+...+++.++ T Consensus 105 ----~~~~~~~~~iilvgnK~Dl-----------~~~~~v~~~~~~~~~~~~~~~~~e~Sa~~~~~i~~~f~~l~~~i~ 168 (175) T 2nzj_A 105 ----RTHQADHVPIILVGNKADL-----------ARCREVSVEEGRACAVVFDCKFIETSATLQHNVAELFEGVVRQLR 168 (175) T ss_dssp ----HC----CCCEEEEEECTTC-----------TTTCCSCHHHHHHHHHHHTSEEEECBTTTTBSHHHHHHHHHHHHH T ss_pred ----HHCCCCCEEEEEEECCCCH-----------HHHHCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHH T ss_conf ----3125774279998147661-----------122044177888899974981899862588788899999999999 No 86 >cd04139 RalA_RalB RalA/RalB subfamily. The Ral (Ras-like) subfamily consists of the highly homologous RalA and RalB. Ral proteins are believed to play a crucial role in tumorigenesis, metastasis, endocytosis, and actin cytoskeleton dynamics. Despite their high sequence similarity (80% sequence identity), nonoverlapping and opposing functions have been assigned to RalA and RalBs in tumor migration. In human bladder and prostate cancer cells, RalB promotes migration while RalA inhibits it. A Ral-specific set of GEFs has been identified that are activated by Ras binding. This RalGEF activity is enhanced by Ras binding to another of its target proteins, phosphatidylinositol 3-kinase (PI3K). Ral effectors include RLIP76/RalBP1, a Rac/cdc42 GAP, and the exocyst (Sec6/8) complex, a heterooctomeric protein complex that is involved in tethering vesicles to specific sites on the plasma membrane prior to exocytosis. In rat kidney cells, RalB is required for functional assembly of the exo Probab=98.73 E-value=1.1e-06 Score=67.42 Aligned_columns=157 Identities=22% Q ss_pred EEEEECCCCCHHHHHHHHHC---CCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEE Q ss_conf 88860788548999998620---133678743103353021213473001005885676021135322477343302102 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTKLQG---AEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLV 133 (492) Q Consensus 57 ILvLG~~~sGKttLi~~Lq~---~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlV 133 (492) |+++|+.++|||+|+.++.. .++.....|..|. ..+..+.+ ...+.+|=..|.-.+..|.+..+.--+ .+ T Consensus 3 ivliGd~~VGKTsli~r~~~~~f~~~~~~Ti~~~~~-~~i~~~~~--~v~l~iwDt~Gqe~~~~l~~~~~~~a~----~~ 75 (164) T cd04139 3 VIVVGAGGVGKSALTLQFMYDEFVEDYEPTKADSYR-KKVVLDGE--DVQLNILDTAGQEDYAAIRDNYHRSGE----GF 75 (164) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCEEE-EEEEECCC--EEEEEEEECCCCHHHHHHHHHHCCCCC----EE T ss_conf 899817985489999998718207654432232146-89988593--899998427887135788887525898----79 Q ss_pred EEHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCC Q ss_conf 00021203247999999999999999972488889999999999999862035000577776766454566540000368 Q Ver_Hs_NP_0061 134 IFVADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALP 213 (492) Q Consensus 134 vI~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lP 213 (492) +||-|.+.+.++ +.+.+|..-+..+... T Consensus 76 ilvydit~~~Sf-~~i~~~~~~~~~~~~~--------------------------------------------------- 103 (164) T cd04139 76 LLVFSITDMESF-TATAEFREQILRVKDD--------------------------------------------------- 103 (164) T ss_pred EEEEECCCHHHH-HHHHHHHHHHHHHHCC--------------------------------------------------- T ss_conf 999752885578-8999999999986179--------------------------------------------------- Q ss_pred CCCCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHH Q ss_conf 8876221479940799850752255554205774778999999999999870873788456663567999999988872 Q Ver_Hs_NP_0061 214 LGDNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTY 292 (492) Q Consensus 214 Lgeg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~Hrly 292 (492) +. +|+++|.+|+|. +++--+-....+.+|-++|+..|-||++...|++-+.+.|.-+++ T Consensus 104 --~~-------ip~ilvGNK~Dl-----------~~~r~v~~~e~~~~a~~~~~~~~E~SAk~g~ni~e~F~~l~~~i~ 162 (164) T cd04139 104 --DN-------VPLLLVGNKCDL-----------EDKRQVSSEEAANLARQWGVPYVETSAKTRQNVEKAFYDLVREIR 162 (164) T ss_pred --CC-------CEEEEECCCHHH-----------HHHCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHH T ss_conf --97-------279997240132-----------231167489999999965995999971589887899999999996 No 87 >d1wmsa_ c.37.1.8 (A:) Rab9a {Human (Homo sapiens)} SCOP: d1s8fb_ d1wmsb_ d1s8fa_ u1yzla1 Probab=98.73 E-value=2.7e-06 Score=64.74 Aligned_columns=160 Identities=21% Q ss_pred EEEEECCCCCHHHHHHHHHC---CCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEE Q ss_conf 88860788548999998620---133678743103353021213473001005885676021135322477343302102 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTKLQG---AEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLV 133 (492) Q Consensus 57 ILvLG~~~sGKttLi~~Lq~---~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlV 133 (492) |+++|..++|||||+.+|.+ .+.....-+.+|....+..+.. ...+.+|-..|.-.+..+.+..+..-. .+ T Consensus 9 i~iiG~~~vGKTsLi~~l~~~~~~~~~~~t~~~~~~~~~~~~~~~--~~~l~i~d~~~~~~~~~~~~~~~~~~d----~i 82 (174) T d1wmsa_ 9 VILLGDGGVGKSSLMNRYVTNKFDTQLFHTIGVEFLNKDLEVDGH--FVTMQIWDTAGQERFRSLRTPFYRGSD----CC 82 (174) T ss_dssp EEEECCTTSSHHHHHHHHHHSCCCC----CCSEEEEEEEEEETTE--EEEEEEEECCCCGGGHHHHGGGGTTCS----EE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEECCEEEEEEECCE--EEEEEEEECCCCHHHHHHHHHHHCCCC----EE T ss_conf 999817998789999998648135663321430104789998893--889987202464023454444205772----79 Q ss_pred EEHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCC Q ss_conf 00021203247999999999999999972488889999999999999862035000577776766454566540000368 Q Ver_Hs_NP_0061 134 IFVADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALP 213 (492) Q Consensus 134 vI~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lP 213 (492) |++.|++.+ .-.+.+..|...++.+....... T Consensus 83 i~v~D~s~~-~s~~~i~~~~~~i~~~~~~~~~~----------------------------------------------- 114 (174) T d1wmsa_ 83 LLTFSVDDS-QSFQNLSNWKKEFIYYADVKEPE----------------------------------------------- 114 (174) T ss_dssp EEEEETTCH-HHHHTHHHHHHHHHHHHTCSCTT----------------------------------------------- T ss_pred EEEEECCCH-HHHHHHHHHHHHHHHHCCCCCCC----------------------------------------------- T ss_conf 999852886-79998855678887640456778----------------------------------------------- Q ss_pred CCCCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEE-ECCCCCCCHHHHHHHHHHHHH Q ss_conf 8876221479940799850752255554205774778999999999999870873788-456663567999999988872 Q Ver_Hs_NP_0061 214 LGDNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIY-TSVKEEKNLDLLYKYIVHKTY 292 (492) Q Consensus 214 Lgeg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiY-TS~ke~kNl~lLykYi~Hrly 292 (492) ++|+++|++|+| |..+.-..+| ++.++-+++.-.+| ||++...|++-+...++.+++ T Consensus 115 ----------~~piilv~nK~D----l~~~~v~~~e--------~~~~~~~~~~~~~~e~Sak~g~~v~e~f~~l~~~il 172 (174) T d1wmsa_ 115 ----------SFPFVILGNKID----ISERQVSTEE--------AQAWCRDNGDYPYFETSAKDATNVAAAFEEAVRRVL 172 (174) T ss_dssp ----------TSCEEEEEECTT----CSSCSSCHHH--------HHHHHHHTTCCCEEECCTTTCTTHHHHHHHHHHHHH T ss_pred ----------CCCEEEEECCCC----CCCCCCCHHH--------HHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHH T ss_conf ----------861899950558----2213588899--------999999707970899860589888899999999985 No 88 >cd04123 Rab21 Rab21 subfamily. The localization and function of Rab21 are not clearly defined, with conflicting data reported. Rab21 has been reported to localize in the ER in human intestinal epithelial cells, with partial colocalization with alpha-glucosidase, a late endosomal/lysosomal marker. More recently, Rab21 was shown to colocalize with and affect the morphology of early endosomes. In Dictyostelium, GTP-bound Rab21, together with two novel LIM domain proteins, LimF and ChLim, has been shown to regulate phagocytosis. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site Probab=98.73 E-value=9.4e-07 Score=67.82 Aligned_columns=159 Identities=20% Q ss_pred EEEEECCCCCHHHHHHH-HHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEEEE Q ss_conf 88860788548999998-62013367874310335302121347300100588567602113532247734330210200 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTK-LQGAEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLVIF 135 (492) Q Consensus 57 ILvLG~~~sGKttLi~~-Lq~~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlVvI 135 (492) |+++|+.++|||+|+.+ +.+....+...-.+..|....=.-.+....+.+|=..|...+..+.+..+.- -..+++ T Consensus 3 i~~iGd~~vGKTsli~r~~~~~f~~~~~~ti~~~~~~k~i~~~~~~~~l~iwDt~G~~~~~~~~~~~~~~----a~~~il 78 (162) T cd04123 3 VVLLGEGRVGKTSLVLRYVENKFNEKHESTTQASFFQKTVNIGGKRIDLAIWDTAGQERYHALGPIYYRD----ADGAIL 78 (162) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCEEEEEEEECCCCHHHHHHHHHHHCC----CCEEEE T ss_conf 8998269965899999986281177645411244135533159938999973078750235665766148----986899 Q ss_pred HHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCCCC Q ss_conf 02120324799999999999999997248888999999999999986203500057777676645456654000036888 Q Ver_Hs_NP_0061 136 VADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLG 215 (492) Q Consensus 136 ~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lPLg 215 (492) |-|.+.+ .-.+.++.|+.-++++... T Consensus 79 vydit~~-~Sf~~i~~w~~~i~~~~~~----------------------------------------------------- 104 (162) T cd04123 79 VYDITDA-DSFQKVKKWIKELKQMRGN----------------------------------------------------- 104 (162) T ss_pred EEECCCH-HHHHHHHHHHHHHHHHCCC----------------------------------------------------- T ss_conf 9427987-7899999999989973189----------------------------------------------------- Q ss_pred CCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHH Q ss_conf 76221479940799850752255554205774778999999999999870873788456663567999999988872 Q Ver_Hs_NP_0061 216 DNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTY 292 (492) Q Consensus 216 eg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~Hrly 292 (492) .+|+++|.+|+|. +++..+=..-.+.+|-++|+..+-||+|...|++-+...|.-++. T Consensus 105 --------~~piilVGNK~Dl-----------~~~r~V~~~~~~~~a~~~~~~~~E~Sak~~~nv~e~F~~l~~~il 162 (162) T cd04123 105 --------NISLVIVGNKIDL-----------ERQRVVSKSEAEEYAKSVGAKHFETSAKTGKGIEELFLSLAKRMI 162 (162) T ss_pred --------CCEEEEEEEHHHH-----------HHHCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHC T ss_conf --------9659998400231-----------210254778999999964993899971589787899999999829 No 89 >cd04127 Rab27A Rab27a subfamily. The Rab27a subfamily consists of Rab27a and its highly homologous isoform, Rab27b. Unlike most Rab proteins whose functions remain poorly defined, Rab27a has many known functions. Rab27a has multiple effector proteins, and depending on which effector it binds, Rab27a has different functions as well as tissue distribution and/or cellular localization. Putative functions have been assigned to Rab27a when associated with the effector proteins Slp1, Slp2, Slp3, Slp4, Slp5, DmSlp, rabphilin, Dm/Ce-rabphilin, Slac2-a, Slac2-b, Slac2-c, Noc2, JFC1, and Munc13-4. Rab27a has been associated with several human diseases, including hemophagocytic syndrome (Griscelli syndrome or GS), Hermansky-Pudlak syndrome, and choroidermia. In the case of GS, a rare, autosomal recessive disease, a Rab27a mutation is directly responsible for the disorder. When Rab27a is localized to the secretory granules of pancreatic beta cells, it is believed to mediate glucose-stimulated Probab=98.73 E-value=1.7e-06 Score=66.14 Aligned_columns=160 Identities=19% Q ss_pred EEEEECCCCCHHHHHHHHHC---CCCCCCCCCCEEEEEECCCCCCCCC--------CCCCEEEECCCCCCCCCCCCCCCC Q ss_conf 88860788548999998620---1336787431033530212134730--------010058856760211353224773 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTKLQG---AEHGKKGRGLEYLYLSVHDEDRDDH--------TRCNVWILDGDLYHKGLLKFAVSA 125 (492) Q Consensus 57 ILvLG~~~sGKttLi~~Lq~---~e~~kkg~gLeY~Yl~V~D~drDd~--------~R~~VwiLdg~~~~~~LLk~al~~ 125 (492) |+++|+.++|||+|+.++-. .+.....-|+++....+--+..+.. -.+.+|=..|.-.+.+|.+....- T Consensus 7 ivviGd~~vGKTsli~r~~~~~f~~~~~~Tig~~~~~k~i~~~~~~~~~~~~~~~~v~l~iwDtaGqe~~~~l~~~~~~~ 86 (180) T cd04127 7 FLALGDSGVGKTSFLYQYTDNKFNPKFITTVGIDFREKRVVYNSSGPGGTLGRGQRIHLQLWDTAGQERFRSLTTAFFRD 86 (180) T ss_pred EEEEECCCCCHHHHHHHHHCCEECCCCCCEEEEEEEEEEEEEECCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHCCC T ss_conf 99980698438999888763832776354011135577999712554332457727999997247762145676886049 Q ss_pred CCHHHEEEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCC Q ss_conf 43302102000212032479999999999999999724888899999999999998620350005777767664545665 Q Ver_Hs_NP_0061 126 ESLPETLVIFVADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGS 205 (492) Q Consensus 126 ~si~~TlVvI~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~ 205 (492) -..+|||-|.+.+ .-.+++..|+.-++.+..+-..+ T Consensus 87 ----a~~~ilvydit~~-~Sf~~~~~w~~~i~~~~~~~~~~--------------------------------------- 122 (180) T cd04127 87 ----AMGFLLIFDLTNE-QSFLNVRNWMSQLQTHAYCENPD--------------------------------------- 122 (180) T ss_pred ----CCEEEEEEECCCH-HHHHHHHHHHHHHHHHCCCCCCE--------------------------------------- T ss_conf ----9889999746896-68899999999998613678750--------------------------------------- Q ss_pred CCHHCCCCCCCCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHH Q ss_conf 40000368887622147994079985075225555420577477899999999999987087378845666356799999 Q Ver_Hs_NP_0061 206 DEENVALPLGDNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYK 285 (492) Q Consensus 206 de~~v~lPLgeg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLyk 285 (492) +++|++|+| |++++.-..|+ .+.||-.+|...|.||+|...|++-+.. T Consensus 123 ---------------------ivlVgNK~D----l~~~r~Vs~~e-------~~~~a~~~~~~~~e~SAk~~~nV~e~F~ 170 (180) T cd04127 123 ---------------------IVLCGNKAD----LEDQRQVSEEQ-------AKALADKYGIPYFETSAATGTNVEKAVE 170 (180) T ss_pred ---------------------EEEEECCCC----CCCCCCCCHHH-------HHHHHHHCCCCEEEEECCCCCCHHHHHH T ss_conf ---------------------788720235----52112248789-------9999996599599997147988789999 Q ss_pred HHHHHHH Q ss_conf 9988872 Q Ver_Hs_NP_0061 286 YIVHKTY 292 (492) Q Consensus 286 Yi~Hrly 292 (492) +|+-.++ T Consensus 171 ~l~~~i~ 177 (180) T cd04127 171 RLLDLVM 177 (180) T ss_pred HHHHHHH T ss_conf 9999999 No 90 >2a5j_A RAS-related protein RAB-2B; GTPase, signal transduction, structural genomics, structural genomics consortium, SGC; HET: GDP; 1.50A {Homo sapiens} SCOP: c.37.1.8 Probab=98.72 E-value=1.1e-06 Score=67.33 Aligned_columns=175 Identities=19% Q ss_pred HHHHHHHHHCCCCCCCCCC---EEEEEECCCCCHHHHHHHHHC---CCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEEC Q ss_conf 9999999817862278876---488860788548999998620---1336787431033530212134730010058856 Q Ver_Hs_NP_0061 37 SSILSEVSTRARSKLPSGK---NILVFGEDGSGKTTLMTKLQG---AEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILD 110 (492) Q Consensus 37 ssil~eV~~~~~~klp~~K---nILvLG~~~sGKttLi~~Lq~---~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLd 110 (492) ||-.+.-++.+- -|.+. .|+|+|+.++|||+|+.+|.+ .+......+.++....+.. .+...++.+|-.. T Consensus 3 ~~~~~~~~~~~~--~p~~~~~~KIvivG~~~vGKTSLi~~l~~~~f~~~~~~t~~~~~~~~~~~~--~~~~~~~~i~d~~ 78 (191) T 2a5j_A 3 SSHHHHHHSSGL--VPRGSYLFKYIIIGDTGVGKSCLLLQFTDKRFQPVHDLTIGVEFGARMVNI--DGKQIKLQIWDTA 78 (191) T ss_dssp -------CCCCC--CCTTCEEEEEEEESSTTSSHHHHHHHHHHSCCCC-----CCSSEEEEEEEE--TTEEEEEEEECCT T ss_pred CCCCCCCCCCCC--CCCCCCEEEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCEECCCCEEEEEE--CCEEEEEEEEECC T ss_conf 542344444578--987343278999817997689999998638226762451101230454221--2505777763021 Q ss_pred CCCCCCCCCCCCCCCCCHHHEEEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHC Q ss_conf 76021135322477343302102000212032479999999999999999724888899999999999998620350005 Q Ver_Hs_NP_0061 111 GDLYHKGLLKFAVSAESLPETLVIFVADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEG 190 (492) Q Consensus 111 g~~~~~~LLk~al~~~si~~TlVvI~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~ 190 (492) |...+..+.+.....-+ .+++|.|+++++++ +....++.....+..+. T Consensus 79 g~~~~~~~~~~~~~~~d----~ii~vfd~~d~~sf--------------------------~~~~~~~~~~~~~~~~~-- 126 (191) T 2a5j_A 79 GQESFRSITRSYYRGAA----GALLVYDITRRETF--------------------------NHLTSWLEDARQHSSSN-- 126 (191) T ss_dssp TGGGTSCCCHHHHTTCS----EEEEEEETTCHHHH--------------------------HTHHHHHHHHHHHSCTT-- T ss_pred CHHHHHHHHHHHHHCCC----EEEEEEEECCCHHH--------------------------HHHHHHHHHCCCCCCCC-- T ss_conf 11122234365431277----57999840562058--------------------------88876421001247997-- Q ss_pred CCCCCCCCCCCCCCCCCHHCCCCCCCCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEE Q ss_conf 77776766454566540000368887622147994079985075225555420577477899999999999987087378 Q Ver_Hs_NP_0061 191 CQGSPQRRGPLTSGSDEENVALPLGDNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALI 270 (492) Q Consensus 191 ~~gs~~r~~~~~s~~de~~v~lPLgeg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLi 270 (492) +|++||++|+|. +....+-.+-++.+|-+++...+ T Consensus 127 ----------------------------------~piilv~nK~D~-----------~~~~~v~~~e~~~~~~~~~~~~~ 161 (191) T 2a5j_A 127 ----------------------------------MVIMLIGNKSDL-----------ESRRDVKREEGEAFAREHGLIFM 161 (191) T ss_dssp ----------------------------------CEEEEEEECTTC-----------GGGCCSCHHHHHHHHHHHTCEEE T ss_pred ----------------------------------EEEEEECCCCCH-----------HHHCCCCHHHHHHHHHHCCCEEE T ss_conf ----------------------------------079985153200-----------02105568899999996599099 Q ss_pred EECCCCCCCHHHHHHHHHHHHH Q ss_conf 8456663567999999988872 Q Ver_Hs_NP_0061 271 YTSVKEEKNLDLLYKYIVHKTY 292 (492) Q Consensus 271 YTS~ke~kNl~lLykYi~Hrly 292 (492) .||++...|++-+...+++.++ T Consensus 162 e~Sak~g~gI~elf~~i~~~i~ 183 (191) T 2a5j_A 162 ETSAKTACNVEEAFINTAKEIY 183 (191) T ss_dssp EECTTTCTTHHHHHHHHHHHHH T ss_pred EEECCCCCCHHHHHHHHHHHHH T ss_conf 9961689788899999999999 No 91 >e2f9la1 c.37.1.8 (A:8-182) Rab11b {Human (Homo sapiens) [TaxID:9606]} SCOP: u2f9ma_ u1yzka_ d1oiva_ d1oiwa_ u1oixa_ Probab=98.72 E-value=4.8e-07 Score=69.79 Aligned_columns=159 Identities=19% Q ss_pred EEEEECCCCCHHHHHHHHHCCC-CCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEEEE Q ss_conf 8886078854899999862013-367874310335302121347300100588567602113532247734330210200 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTKLQGAE-HGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLVIF 135 (492) Q Consensus 57 ILvLG~~~sGKttLi~~Lq~~e-~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlVvI 135 (492) |+++|+.++|||||+.+|.+.+ ........+...........+....+.+|-..|...+..+.+..+.. -..+++ T Consensus 7 I~ivG~~~vGKTSli~~l~~~~~~~~~~~t~~~~~~~~~~~~~~~~~~~~i~D~~g~~~~~~~~~~~~~~----~~~~i~ 82 (175) T e2f9la1 7 VVLIGDSGVGKSNLLSRFTRNEFNLESKSTIGVEFATRSIQVDGKTIKAQIWDTAGQERYRRITSAYYRG----AVGALL 82 (175) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEECCEEEEEECCCEEEEEEECCCCCHHHHHHHHHHHHC----CCEEEE T ss_conf 9998269987999999986581354656415520120556665916898872378830345788987604----533666 Q ss_pred HHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCCCC Q ss_conf 02120324799999999999999997248888999999999999986203500057777676645456654000036888 Q Ver_Hs_NP_0061 136 VADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLG 215 (492) Q Consensus 136 ~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lPLg 215 (492) |.|.+.+ ...+.+.+|...++.+. T Consensus 83 v~d~~~~-~s~~~~~~~~~~i~~~~------------------------------------------------------- 106 (175) T e2f9la1 83 VYDIAKH-LTYENVERWLKELRDHA------------------------------------------------------- 106 (175) T ss_pred EEECCCC-CCHHHHHHHHHHHHHHC------------------------------------------------------- T ss_conf 5312454-30688999999886404------------------------------------------------------- Q ss_pred CCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHH Q ss_conf 76221479940799850752255554205774778999999999999870873788456663567999999988872 Q Ver_Hs_NP_0061 216 DNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTY 292 (492) Q Consensus 216 eg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~Hrly 292 (492) ..++|+++|.+|+|..+ ++.-.+.+ ++.++..++...+.||++...|++-+.+.++..+| T Consensus 107 ------~~~~piiivgnK~Dl~~--~~~i~~~~---------~~~~~~~~~~~~~e~Sak~~~~I~e~f~~i~~~i~ 166 (175) T e2f9la1 107 ------DSNIVIMLVGNKSDLRH--LRAVPTDE---------ARAFAEKNNLSFIETSALDSTNVEEAFKNILTEIY 166 (175) T ss_pred ------CCCEEEHHHHHHHHHHH--CCCCCHHH---------HHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHH T ss_conf ------78502102100001321--26778899---------99999972983899950689788899999999999 No 92 >2atv_A RERG, RAS-like estrogen-regulated growth inhibitor; GDP/GTP binding, GTP hydrolysis, structural genomics, structural genomics consortium, SGC; HET: GDP; 1.90A {Homo sapiens} SCOP: c.37.1.8 Probab=98.72 E-value=1.9e-06 Score=65.71 Aligned_columns=159 Identities=17% Q ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEEEEH Q ss_conf 88860788548999998620133678743103353021213473001005885676021135322477343302102000 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTKLQGAEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLVIFV 136 (492) Q Consensus 57 ILvLG~~~sGKttLi~~Lq~~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlVvI~ 136 (492) |+|+|+.++||||||.++.+.+-...-...-..-+...-.-.+..-++.+|-..|...+..+..+..+++ .+|++ T Consensus 31 I~viG~~~vGKTsLi~~~~~~~~~~~~~~Ti~~~~~~~~~~~~~~~~l~i~d~~g~~~~~~~~~~~~~~d-----~~ilv 105 (196) T 2atv_A 31 LAIFGRAGVGKSALVVRFLTKRFIWEYDPTLESTYRHQATIDDEVVSMEILDTAGQEDTIQREGHMRWGE-----GFVLV 105 (196) T ss_dssp EEEECCTTSSHHHHHHHHHHSCCCSCCCTTCCEEEEEEEEETTEEEEEEEEECCCCCCCHHHHHHHHHCS-----EEEEE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEECCEEEEEEEECCCCCCHHHHHHHHCCCCC-----EEEEE T ss_conf 9998079977899999986381576545310036889888615688887740444320122012003560-----47899 Q ss_pred HHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCCCCC Q ss_conf 21203247999999999999999972488889999999999999862035000577776766454566540000368887 Q Ver_Hs_NP_0061 137 ADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLGD 216 (492) Q Consensus 137 lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lPLge 216 (492) .|.+.|.++-. +..|...+. T Consensus 106 fD~~~~~S~~~-~~~~~~~~~----------------------------------------------------------- 125 (196) T 2atv_A 106 YDITDRGSFEE-VLPLKNILD----------------------------------------------------------- 125 (196) T ss_dssp EETTCHHHHHT-HHHHHHHHH----------------------------------------------------------- T ss_pred EEECCCCCHHH-HHHHHHCCC----------------------------------------------------------- T ss_conf 98504546224-555531011----------------------------------------------------------- Q ss_pred CCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCC-CHHHHHHHHHHHHH Q ss_conf 62214799407998507522555542057747789999999999998708737884566635-67999999988872 Q Ver_Hs_NP_0061 217 NVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEK-NLDLLYKYIVHKTY 292 (492) Q Consensus 217 g~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~k-Nl~lLykYi~Hrly 292 (492) .....-.+|+++|++|+| |+++..-..++ ++.||=.+|+..|.||++... |++-+..-+++.++ T Consensus 126 -~~~~~~~~piilVgnK~D----l~~~r~i~~~e-------~~~~a~~~~~~~~e~Sak~g~~nV~e~f~~l~~~i~ 190 (196) T 2atv_A 126 -EIKKPKNVTLILVGNKAD----LDHSRQVSTEE-------GEKLATELACAFYECSACTGEGNITEIFYELCREVR 190 (196) T ss_dssp -HHHTTSCCCEEEEEECGG----GGGGCCSCHHH-------HHHHHHHHTSEEEECCTTTCTTCHHHHHHHHHHHHH T ss_pred -CCCCCCCCEEEEEECCCC----CCHHCCCCHHH-------HHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHH T ss_conf -223678861899952534----10011677889-------999999649948999720588247889999999999 No 93 >d1ky3a_ c.37.1.8 (A:) Rab-related protein ypt7p {Baker's yeast (Saccharomyces cerevisiae)} SCOP: d1ky2a_ Probab=98.71 E-value=4e-06 Score=63.64 Aligned_columns=165 Identities=22% Q ss_pred EEEEEECCCCCHHHHHHHHHC---CCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEE Q ss_conf 488860788548999998620---13367874310335302121347300100588567602113532247734330210 Q Ver_Hs_NP_0061 56 NILVFGEDGSGKTTLMTKLQG---AEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETL 132 (492) Q Consensus 56 nILvLG~~~sGKttLi~~Lq~---~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~Tl 132 (492) .|+|+|..++|||||+.+|-+ .+.....-+.+|......... .......+|-..+...+..+....+..-+ . T Consensus 4 ki~iiG~~~vGKStli~~l~~~~~~~~~~~t~~~~~~~~~~~~~~-~~~~~~~i~d~~~~~~~~~~~~~~~~~~d----~ 78 (175) T d1ky3a_ 4 KVIILGDSGVGKTSLMHRYVNDKYSQQYKATIGADFLTKEVTVDG-DKVATMQVWDTAGQERFQSLGVAFYRGAD----C 78 (175) T ss_dssp EEEEECCTTSSHHHHHHHHHHSCCCTTC---CCCSCEEEEECCSS-SCCEEEEEECCC----------CCSTTCC----E T ss_pred EEEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEEECC-CCEEEEEEECCCHHHHHHHHHHHHHCCCC----E T ss_conf 899980799889999999864801566145167535677776336-61489997115101233110021211110----2 Q ss_pred EEEHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCC Q ss_conf 20002120324799999999999999997248888999999999999986203500057777676645456654000036 Q Ver_Hs_NP_0061 133 VIFVADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVAL 212 (492) Q Consensus 133 VvI~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~l 212 (492) +++|.|.+.+..+-. +..|...++.+.. T Consensus 79 ~ilv~D~~~~~s~~~-~~~~~~~i~~~~~--------------------------------------------------- 106 (175) T d1ky3a_ 79 CVLVYDVTNASSFEN-IKSWRDEFLVHAN--------------------------------------------------- 106 (175) T ss_dssp EEEEEETTCHHHHHT-HHHHHHHHHHHHC--------------------------------------------------- T ss_pred EEEEEECCCCCCHHH-HHHHHHHHHHHHH--------------------------------------------------- T ss_conf 244320036561457-7776899999863--------------------------------------------------- Q ss_pred CCCCCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHH Q ss_conf 88876221479940799850752255554205774778999999999999870873788456663567999999988872 Q Ver_Hs_NP_0061 213 PLGDNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTY 292 (492) Q Consensus 213 PLgeg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~Hrly 292 (492) ....-++|++||++|+|..+ +++.-..++-..+...+ .....+.||++...|++-+...|.-..+ T Consensus 107 ------~~~~~~~Piiiv~nK~Dl~~--~~~~~~~~~~~~~~~~~-------~~~~~~e~Sa~~g~gi~e~f~~i~~~al 171 (175) T d1ky3a_ 107 ------VNSPETFPFVILGNKIDAEE--SKKIVSEKSAQELAKSL-------GDIPLFLTSAKNAINVDTAFEEIARSAL 171 (175) T ss_dssp ------CSCTTTCCEEEEEECTTSCG--GGCCSCHHHHHHHHHHT-------TSCCEEEEBTTTTBSHHHHHHHHHHHHH T ss_pred ------HCCCCCEEEEEEEECCCCCC--CCCCCCHHHHHHHHHHH-------CCCCEEEEECCCCCCHHHHHHHHHHHHH T ss_conf ------12889727999851246400--02655688999999980-------7971899861688688899999999999 No 94 >d1m7ba_ c.37.1.8 (A:) RhoE (RND3) {Mouse (Mus musculus)} Probab=98.71 E-value=9.2e-07 Score=67.89 Aligned_columns=166 Identities=20% Q ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEEEEH Q ss_conf 88860788548999998620133678743103353021213473001005885676021135322477343302102000 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTKLQGAEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLVIFV 136 (492) Q Consensus 57 ILvLG~~~sGKttLi~~Lq~~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlVvI~ 136 (492) |+|+|+.++|||+|+.++.+.+........-.....+.=...+..-++.+|-..|...+.++.+.....-+ .+||| T Consensus 5 I~iiG~~~vGKTsli~~~~~~~f~~~~~~t~~~~~~~~~~~~~~~~~~~i~D~~g~~~~~~~~~~~~~~~d----~~iiv 80 (179) T d1m7ba_ 5 IVVVGDSQCGKTALLHVFAKDCFPENYVPTVFENYTASFEIDTQRIELSLWDTSGSPYYDNVRPLSYPDSD----AVLIC 80 (179) T ss_dssp EEEEESTTSSHHHHHHHHHHSCCCSSCCCCSEEEEEEEEECSSCEEEEEEEEECCSGGGTTTGGGGCTTCS----EEEEE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEECCCCCCEEEEECCCCCCCCCHHHHHHHCCCC----EEEEE T ss_conf 99970699878999999862823666343367621343201331102686114432100000056632786----57999 Q ss_pred HHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCCCCC Q ss_conf 21203247999999999999999972488889999999999999862035000577776766454566540000368887 Q Ver_Hs_NP_0061 137 ADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLGD 216 (492) Q Consensus 137 lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lPLge 216 (492) -|++.++.+-.-++.|...++.. T Consensus 81 ydv~~~~Sf~~i~~~~~~~~~~~--------------------------------------------------------- 103 (179) T d1m7ba_ 81 FDISRPETLDSVLKKWKGEIQEF--------------------------------------------------------- 103 (179) T ss_dssp EETTCHHHHHHHHHTHHHHHHHH--------------------------------------------------------- T ss_pred EECCCCHHHHHHHHHHHHHHHHH--------------------------------------------------------- T ss_conf 80686035788988777777640--------------------------------------------------------- Q ss_pred CCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHH-HHHHHHHHCCCEEEE-ECCCCCCC-HHHHHHHHH Q ss_conf 6221479940799850752255554205774778999999-999999870873788-45666356-799999998 Q Ver_Hs_NP_0061 217 NVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQS-HLRRFCLQYGAALIY-TSVKEEKN-LDLLYKYIV 288 (492) Q Consensus 217 g~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq-~LR~~cL~YGAsLiY-TS~ke~kN-l~lLykYi~ 288 (492) .-.+|+++|++|+|.-+......+...+.--.|.+ -.+.+|-++||..+| ||++...| ++-+.+.+. T Consensus 104 -----~~~~piilvgnK~DL~~~~~~~~~~~~~~~~~Vs~~e~~~la~~~~~~~y~E~SA~t~~n~v~~~F~~~~ 173 (179) T d1m7ba_ 104 -----CPNTKMLLVGCKSDLRTDVSTLVELSNHRQTPVSYDQGANMAKQIGAATYIECSALQSENSVRDIFHVAT 173 (179) T ss_dssp -----CTTCEEEEEEECGGGGGCHHHHHHHHTTTCCCCCHHHHHHHHHHHTCSEEEECBTTTBHHHHHHHHHHHH T ss_pred -----CCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHH T ss_conf -----2674157875266632103456654430376589899999999708952898750368840899999999 No 95 >cd04113 Rab4 Rab4 subfamily. Rab4 has been implicated in numerous functions within the cell. It helps regulate endocytosis through the sorting, recycling, and degradation of early endosomes. Mammalian Rab4 is involved in the regulation of many surface proteins including G-protein-coupled receptors, transferrin receptor, integrins, and surfactant protein A. Experimental data implicate Rab4 in regulation of the recycling of internalized receptors back to the plasma membrane. It is also believed to influence receptor-mediated antigen processing in B-lymphocytes, in calcium-dependent exocytosis in platelets, in alpha-amylase secretion in pancreatic cells, and in insulin-induced translocation of Glut4 from internal vesicles to the cell surface. Rab4 is known to share effector proteins with Rab5 and Rab11. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to p Probab=98.71 E-value=9.3e-07 Score=67.86 Aligned_columns=158 Identities=21% Q ss_pred EEEEECCCCCHHHHHHH-HHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEEEE Q ss_conf 88860788548999998-62013367874310335302121347300100588567602113532247734330210200 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTK-LQGAEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLVIF 135 (492) Q Consensus 57 ILvLG~~~sGKttLi~~-Lq~~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlVvI 135 (492) |+++|+.++|||+|+.+ +.+.....-..-++..|....=...+...++.+|=..|.-.+..|.+....- -..+|| T Consensus 3 iviiGd~~VGKTsli~~~~~~~f~~~~~~Tig~~~~~~~i~~~~~~~~l~i~Dt~G~e~~~~l~~~~~~~----a~~~ii 78 (161) T cd04113 3 FIIIGSSGTGKSCLLHRFVENKFKEDSQHTIGVEFGSKIIRVGGKRVKLQIWDTAGQERFRSVTRSYYRG----AAGALL 78 (161) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEECCEEEEEEEEECCCCCHHHHHHHHHCCC----CCEEEE T ss_conf 8998269855899999986281066656410120135899888969999983258870134555864269----977999 Q ss_pred HHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCCCC Q ss_conf 02120324799999999999999997248888999999999999986203500057777676645456654000036888 Q Ver_Hs_NP_0061 136 VADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLG 215 (492) Q Consensus 136 ~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lPLg 215 (492) |-|.+.+..+ +.+++|+.-+|.+-.. T Consensus 79 vydi~~~~Sf-~~i~~w~~~~~~~~~~----------------------------------------------------- 104 (161) T cd04113 79 VYDITNRTSF-EALPTWLSDARALASP----------------------------------------------------- 104 (161) T ss_pred EEECCCHHHH-HHHHHHHHHHHHHCCC----------------------------------------------------- T ss_conf 9855986689-9999999999872489----------------------------------------------------- Q ss_pred CCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHH Q ss_conf 7622147994079985075225555420577477899999999999987087378845666356799999998887 Q Ver_Hs_NP_0061 216 DNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKT 291 (492) Q Consensus 216 eg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~Hrl 291 (492) .+|+++|++|+|. .+...+=..-.+.+|-++|...+.||+|...|++-+...+.-.+ T Consensus 105 --------~~~iilvgNK~DL-----------~~~r~v~~~e~~~~a~~~~~~~~e~Sak~~~ni~e~F~~lar~i 161 (161) T cd04113 105 --------NIVVILVGNKSDL-----------ADQREVTFLEASRFAQENGLLFLETSALTGENVEEAFLKCARSI 161 (161) T ss_pred --------CCEEEEEECCCCC-----------CCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHC T ss_conf --------9689998324564-----------21334588999999996599099997158988889999999829 No 96 >d1ukvy_ c.37.1.8 (Y:) GTPase Ytp1 {Baker's yeast (Saccharomyces cerevisiae)} Probab=98.70 E-value=9.2e-07 Score=67.90 Aligned_columns=156 Identities=17% Q ss_pred EEEEECCCCCHHHHHHHHHC---CCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEE Q ss_conf 88860788548999998620---133678743103353021213473001005885676021135322477343302102 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTKLQG---AEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLV 133 (492) Q Consensus 57 ILvLG~~~sGKttLi~~Lq~---~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlV 133 (492) |+|+|+.++||||||.++.+ ........+.+|.+..+..... ..++.+|-..|...+..+.+....--. .+ T Consensus 9 I~iiG~~~vGKTSLi~~~~~~~~~~~~~~t~~~~~~~~~~~~~~~--~~~i~i~D~~g~e~~~~~~~~~~~~ad----~i 82 (204) T d1ukvy_ 9 LLLIGNSGVGKSCLLLRFSDDTYTNDYISTIGVDFKIKTVELDGK--TVKLQIWDTAGQERFRTITSSYYRGSH----GI 82 (204) T ss_dssp EEEEESTTSSHHHHHHHHHHSCCCTTCCCSSCCCEEEEEEEETTE--EEEEEEECCTTTTTTTCCCHHHHTTCS----EE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEECCE--EEEEEEECCCCCCHHHHHHHHHHCCCC----EE T ss_conf 889816997799999998648105762452112466889988886--887443026773012345677614797----47 Q ss_pred EEHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCC Q ss_conf 00021203247999999999999999972488889999999999999862035000577776766454566540000368 Q Ver_Hs_NP_0061 134 IFVADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALP 213 (492) Q Consensus 134 vI~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lP 213 (492) |+|.|.+.+.. ++.+..|+.-+...... T Consensus 83 ilvfd~~d~~S-~~~~~~~~~~i~~~~~~--------------------------------------------------- 110 (204) T d1ukvy_ 83 IIVYDVTDQES-FNGVKMWLQEIDRYATS--------------------------------------------------- 110 (204) T ss_dssp EEEEETTCHHH-HHHHHHHHHHHHHHSCT--------------------------------------------------- T ss_pred EEEEECCCHHH-HHHHHHHHHHHHHHHCC--------------------------------------------------- T ss_conf 99985166012-33568999998653102--------------------------------------------------- Q ss_pred CCCCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHH Q ss_conf 887622147994079985075225555420577477899999999999987087378845666356799999998887 Q Ver_Hs_NP_0061 214 LGDNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKT 291 (492) Q Consensus 214 Lgeg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~Hrl 291 (492) .+|+++|++|+|. +++-.+-..-.+.||-.+++..|-||++...|++-++..|...+ T Consensus 111 ----------~~~iiivgnK~D~-----------~~~~~v~~~e~~~~~~~~~~~~~e~SAk~~~gi~e~f~~i~~~i 167 (204) T d1ukvy_ 111 ----------TVLKLLVGNKCDL-----------KDKRVVEYDVAKEFADANKMPFLETSALDSTNVEDAFLTMARQI 167 (204) T ss_dssp ----------TCEEEEEEECTTC-----------TTTCCSCHHHHHHHHHHTTCCEEECCTTTCTTHHHHHHHHHHHH T ss_pred ----------CCEEEEEEECCCC-----------HHCCCCCHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHH T ss_conf ----------4102455411340-----------01025418999999996198189995168988899999999999 No 97 >1kao RAP2A; GTP-binding protein, small G protein, GDP, RAS; HET: GDP; 1.7A {Homo sapiens} SCOP: c.37.1.8 Probab=98.70 E-value=1.9e-06 Score=65.74 Aligned_columns=159 Identities=23% Q ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEEEEH Q ss_conf 88860788548999998620133678743103353021213473001005885676021135322477343302102000 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTKLQGAEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLVIFV 136 (492) Q Consensus 57 ILvLG~~~sGKttLi~~Lq~~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlVvI~ 136 (492) |+++|+.++||||||.+|.+......-....-......=...+..-++.+|...|.-.+..+.+..+ -.--.+++| T Consensus 6 i~liG~~~vGKTSll~~l~~~~~~~~~~~t~~~~~~~~~~~~~~~~~~~~~d~~g~~~~~~~~~~~~----~~~~~~i~v 81 (167) T 1kao 6 VVVLGSGGVGKSALTVQFVTGTFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAGTEQFASMRDLYI----KNGQGFILV 81 (167) T ss_dssp EEEECCTTSSHHHHHHHHHHSCCCSCCCTTCCEEEEEEEEETTEEEEEEEEECCCTTCCHHHHHHHH----HHCSEEEEE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEEEEECCCEEEEEEEECCCCCCCHHHHHHHHH----HCCCEEEEE T ss_conf 9988079987899999986482365534420257766430488268887530567530135677775----201201333 Q ss_pred HHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCCCCC Q ss_conf 21203247999999999999999972488889999999999999862035000577776766454566540000368887 Q Ver_Hs_NP_0061 137 ADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLGD 216 (492) Q Consensus 137 lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lPLge 216 (492) .|.+.++++-.--.-|..+.+.+... T Consensus 82 ~d~~~~~s~~~~~~~~~~~~~~~~~~------------------------------------------------------ 107 (167) T 1kao 82 YSLVNQQSFQDIKPMRDQIIRVKRYE------------------------------------------------------ 107 (167) T ss_dssp EETTCHHHHHHHHHHHHHHHHHTTTS------------------------------------------------------ T ss_pred ECCCCCHHHHHHHHHHHHHHHHCCCC------------------------------------------------------ T ss_conf 22431012211124456776420345------------------------------------------------------ Q ss_pred CCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHH Q ss_conf 622147994079985075225555420577477899999999999987087378845666356799999998887 Q Ver_Hs_NP_0061 217 NVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKT 291 (492) Q Consensus 217 g~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~Hrl 291 (492) .+|++||.+|+| |+.+..-..++ +++|+-.+++.++.||++...|++-+..+++.++ T Consensus 108 -------~~piiiv~nK~D----l~~~~~v~~~~-------~~~~~~~~~~~~~~~Sa~~~~gi~elf~~li~~i 164 (167) T 1kao 108 -------KVPVILVGNKVD----LESEREVSSSE-------GRALAEEWGCPFMETSAKSKTMVDELFAEIVRQM 164 (167) T ss_dssp -------CCCEEEEEECGG----GGGGCCSCHHH-------HHHHHHHHTSCEEEECTTCHHHHHHHHHHHHHHH T ss_pred -------CCEEEEEECCCC----CCCCCCCCHHH-------HHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHH T ss_conf -------411345311221----00001578889-------9999996498089986268868789999999984 No 98 >2bcg_Y Protein YP2, GTP-binding protein YPT1; RABGTPase, geranylgeranylation, vesicular transport; HET: GDP GER; 1.48A {Saccharomyces cerevisiae} SCOP: c.37.1.8 Probab=98.70 E-value=1.2e-06 Score=67.09 Aligned_columns=159 Identities=16% Q ss_pred EEEEECCCCCHHHHHHHHHCCCCCCC-CCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEEEE Q ss_conf 88860788548999998620133678-74310335302121347300100588567602113532247734330210200 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTKLQGAEHGKK-GRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLVIF 135 (492) Q Consensus 57 ILvLG~~~sGKttLi~~Lq~~e~~kk-g~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlVvI 135 (492) |+|+|+.++|||||+.+|.+.+.... -...+..|..+.-..+...-++.+|-..|...+..+.+....- --.+++ T Consensus 11 i~iiG~~~vGKTsLi~~~~~~~~~~~~~~t~~~~~~~~~~~~~~~~~~~~i~D~~g~~~~~~~~~~~~~~----a~~~i~ 86 (206) T 2bcg_Y 11 LLLIGNSGVGKSCLLLRFSDDTYTNDYISTIGVDFKIKTVELDGKTVKLQIWDTAGQERFRTITSSYYRG----SHGIII 86 (206) T ss_dssp EEEEESTTSSHHHHHHHHHHCCCCTTCCCSSCCCEEEEEEEETTEEEEEEEECCTTTTTTTCCCGGGGTT----CSEEEE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEEEEEEEEEEEEECCCCCHHHHHHHHHCCC----CCEEEE T ss_conf 9998369977899999986481167614420335679999986468999986257852245687975258----857999 Q ss_pred HHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCCCC Q ss_conf 02120324799999999999999997248888999999999999986203500057777676645456654000036888 Q Ver_Hs_NP_0061 136 VADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLG 215 (492) Q Consensus 136 ~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lPLg 215 (492) +.|.+.|..+ +++.+|+..+..+... T Consensus 87 v~d~~~~~s~-~~~~~~~~~~~~~~~~----------------------------------------------------- 112 (206) T 2bcg_Y 87 VYDVTDQESF-NGVKMWLQEIDRYATS----------------------------------------------------- 112 (206) T ss_dssp EEETTCHHHH-HHHHHHHHHHHHHSCT----------------------------------------------------- T ss_pred EECCCCCCCC-HHHHHHHHHHHHHHCC----------------------------------------------------- T ss_conf 9706655653-0233455554332036----------------------------------------------------- Q ss_pred CCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHH Q ss_conf 76221479940799850752255554205774778999999999999870873788456663567999999988872 Q Ver_Hs_NP_0061 216 DNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTY 292 (492) Q Consensus 216 eg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~Hrly 292 (492) .+|++||.+|+|. +++..+-+.-.+.|+-.+|+..+.||++...|++-+...|...++ T Consensus 113 --------~~~iilvgnK~D~-----------~~~~~v~~~~~~~~~~~~~~~~~e~Sa~~~~~i~e~f~~l~~~i~ 170 (206) T 2bcg_Y 113 --------TVLKLLVGNKCDL-----------KDKRVVEYDVAKEFADANKMPFLETSALDSTNVEDAFLTMARQIK 170 (206) T ss_dssp --------TCEEEEEEECTTC-----------TTTCCSCHHHHHHHHHHTTCCEEECCTTTCTTHHHHHHHHHHHHH T ss_pred --------CCCEEEEECCCCC-----------CHHHCCHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHH T ss_conf --------8427998536343-----------101010278889999855882689870478888999999999999 No 99 >1gwn_A RHO-related GTP-binding protein RHOE; inactive GTPase, signal transduction; HET: GTP; 2.1A {Mus musculus} SCOP: c.37.1.8 Probab=98.70 E-value=7.2e-07 Score=68.60 Aligned_columns=186 Identities=20% Q ss_pred HHHHHCCCCCCCCCCEE----EEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCC Q ss_conf 99981786227887648----88607885489999986201336787431033530212134730010058856760211 Q Ver_Hs_NP_0061 41 SEVSTRARSKLPSGKNI----LVFGEDGSGKTTLMTKLQGAEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHK 116 (492) Q Consensus 41 ~eV~~~~~~klp~~KnI----LvLG~~~sGKttLi~~Lq~~e~~kkg~gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~ 116 (492) |.+.-++.+-.|. +++ +++|+.++|||||+.+|...+-.......-...+...-...+....+.+|-..|...+. T Consensus 12 ~~~~~~~~~~~~~-~~~~~KI~liG~~~vGKTSli~~l~~~~~~~~~~~ti~~~~~~~~~~~~~~~~i~i~Dt~G~~~~~ 90 (205) T 1gwn_A 12 SGLVPRGSHMDPN-QNVKCKIVVVGDSQCGKTALLHVFAKDCFPENYVPTVFENYTASFEIDTQRIELSLWDTSGSPYYD 90 (205) T ss_dssp ----------------CEEEEEEEESTTSSHHHHHHHHHHSCCCSSCCCCSEEEEEEEEESSSSEEEEEEEEECCSGGGT T ss_pred CCCCCCCCCCCCC-CCCEEEEEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEECCEEEEEEEECCCCCCCCC T ss_conf 3557655578888-873289999816998789999998628447653430244589999863478865431242223443 Q ss_pred CCCCCCCCCCCHHHEEEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCC Q ss_conf 35322477343302102000212032479999999999999999724888899999999999998620350005777767 Q Ver_Hs_NP_0061 117 GLLKFAVSAESLPETLVIFVADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQ 196 (492) Q Consensus 117 ~LLk~al~~~si~~TlVvI~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~ 196 (492) .+.+..+..-.. +|+|.|.+.+.++-.-++.|...++.+... T Consensus 91 ~~~~~~~~~ad~----~ilv~dv~~~~Sf~~~~~~~~~~i~~~~~~---------------------------------- 132 (205) T 1gwn_A 91 NVRPLSYPDSDA----VLICFDISRPETLDSVLKKWKGEIQEFCPN---------------------------------- 132 (205) T ss_dssp TTGGGGCTTCSE----EEEEEETTCHHHHHHHHHTHHHHHHHHCTT---------------------------------- T ss_pred CCCCCCCCCCEE----EEEEEECCCHHHHHHHHHHHHHHHHHHCCC---------------------------------- T ss_conf 234100122011----245763254667778888889999863578---------------------------------- Q ss_pred CCCCCCCCCCCHHCCCCCCCCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHH-HHHHHHHHHHCCCEEEE-ECC Q ss_conf 6645456654000036888762214799407998507522555542057747789999-99999999870873788-456 Q Ver_Hs_NP_0061 197 RRGPLTSGSDEENVALPLGDNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFI-QSHLRRFCLQYGAALIY-TSV 274 (492) Q Consensus 197 r~~~~~s~~de~~v~lPLgeg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~I-qq~LR~~cL~YGAsLiY-TS~ 274 (492) +|+++|.+|+|..+..........+.-..| .+..+.+|-++++-.+| ||+ T Consensus 133 ----------------------------~piiiVgNK~Dl~~~~~~~~~~~~~~~~~I~~~~~~~~a~~~~~~~~~E~SA 184 (205) T 1gwn_A 133 ----------------------------TKMLLVGCKSDLRTDVSTLVELSNHRQTPVSYDQGANMAKQIGAATYIECSA 184 (205) T ss_dssp ----------------------------CEEEEEEECGGGGGCHHHHHHHHTTTCCCCCHHHHHHHHHHHTCSEEEECCT T ss_pred ----------------------------CCEEEEECCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEEEE T ss_conf ----------------------------7279986055765320257888752123568899999999718953899751 Q ss_pred CCCCC-HHHHHHHHHHHHHC Q ss_conf 66356-79999999888727 Q Ver_Hs_NP_0061 275 KEEKN-LDLLYKYIVHKTYG 293 (492) Q Consensus 275 ke~kN-l~lLykYi~Hrlyg 293 (492) +...| ++-++..+++...+ T Consensus 185 ~~~~n~i~evF~~~~~~ii~ 204 (205) T 1gwn_A 185 LQSENSVRDIFHVATLACVN 204 (205) T ss_dssp TTCHHHHHHHHHHHHHHHHH T ss_pred CCCCCHHHHHHHHHHHHHHH T ss_conf 47871589999999999970 No 100 >d1i2ma_ c.37.1.8 (A:) Ran {Human (Homo sapiens)} SCOP: d1k5da_ d1a2ke_ d1rrpa_ d1a2kd_ d1a2kc_ d1qg4a_ d1qg2a_ d1qbkc_ d1byua_ d3ranb_ d3ranc_ d3rana_ d1rrpc_ d1wa5a_ d1ibra_ Probab=98.70 E-value=7.5e-07 Score=68.51 Aligned_columns=159 Identities=21% Q ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCC-CCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHEEEEE Q ss_conf 8886078854899999862013367874-310335302121347300100588567602113532247734330210200 Q Ver_Hs_NP_0061 57 ILVFGEDGSGKTTLMTKLQGAEHGKKGR-GLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLVIF 135 (492) Q Consensus 57 ILvLG~~~sGKttLi~~Lq~~e~~kkg~-gLeY~Yl~V~D~drDd~~R~~VwiLdg~~~~~~LLk~al~~~si~~TlVvI 135 (492) |+++|+.++|||||+.++.+........ .++.-+..+.-...+..-++.+|-..|...+..+.+..+..-+ .+++ T Consensus 6 I~ivG~~~vGKSsLi~~~~~~~~~~~~~~ti~~~~~~~~i~~~~~~~~l~i~D~~g~~~~~~~~~~~~~~~~----~~il 81 (170) T d1i2ma_ 6 LVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLVFHTNRGPIKFNVWDTAGQEKFGGLRDGYYIQAQ----CAII 81 (170) T ss_dssp EEEEECTTSSHHHHHHTTC-----CCEEEETTEEEEEEEECBTTCCEEEEEEECTTHHHHSSCGGGGTTTCC----EEEE T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEEECCCEEEEEEEECCCCHHHCCCCCHHCCCCC----EEEE T ss_conf 999817998799999998638205762444887557899987695147888403330011002300016875----8999 Q ss_pred HHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCHHCCCCCC Q ss_conf 02120324799999999999999997248888999999999999986203500057777676645456654000036888 Q Ver_Hs_NP_0061 136 VADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLG 215 (492) Q Consensus 136 ~lD~s~PW~~m~qL~~Wi~vLr~hi~~L~i~~e~~~e~~~~~~~~~qey~ep~~~~~gs~~r~~~~~s~~de~~v~lPLg 215 (492) |.|.+++..+.. +++|...++.+.... T Consensus 82 v~d~~~~~s~~~-~~~~~~~~~~~~~~~---------------------------------------------------- 108 (170) T d1i2ma_ 82 MFDVTSRVTYKN-VPNWHRDLVRVCENI---------------------------------------------------- 108 (170) T ss_dssp EEETTSGGGGTT-HHHHHHHHHHHHCSC---------------------------------------------------- T ss_pred EEECCCCCCHHH-HHHHHHHHHHHCCCC---------------------------------------------------- T ss_conf 962367640789-999887676415876---------------------------------------------------- Q ss_pred CCCEECCCCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHCCC Q ss_conf 76221479940799850752255554205774778999999999999870873788456663567999999988872777 Q Ver_Hs_NP_0061 216 DNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTYGFH 295 (492) Q Consensus 216 eg~Lt~NLGiPi~VVctKsD~ie~LeKe~~y~dE~fD~Iqq~LR~~cL~YGAsLiYTS~ke~kNl~lLykYi~Hrlygfp 295 (492) |+++|++|+|.. ++.-.+| ...++-++|...+.||++...|++-+..+|...+.+-| T Consensus 109 ----------piiiv~nK~Dl~-----~~~~~~e--------~~~~a~~~~~~~~e~Sak~g~~i~e~f~~l~~~l~~~p 165 (170) T d1i2ma_ 109 ----------PIVLCGNKVDIK-----DRKVKAK--------SIVFHRKKNLQYYDISAKSNYNFEKPFLWLARKLIGDP 165 (170) T ss_dssp ----------CEEEEEECCCCS-----CSCCTTT--------SHHHHSSCSSEEEEEBTTTTBTTTHHHHHHHHHHHTCT T ss_pred ----------EEEEEEECCCHH-----HHHHHHH--------HHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHCCC T ss_conf ----------289997133400-----1001789--------99999846980999971589898899999999984488 Done!