Query Fun_An_XP_001391598.1 Command /cluster/toolkit/production/bioprogs/hhpred/hhsearch -cal -cpu 4 -v 1 -i /cluster/toolkit/production/tmp/production/96219/An_XP_001391598.hhm -d /cluster/toolkit/production/databases/hhpred/new_dbs/pdb70_3Jan08/db/pdb.hhm /cluster/toolkit/production/databases/hhpred/new_dbs/scop70_1.72pre/db/scop.hhm /cluster/toolkit/production/databases/hhpred/new_dbs/scop70_1.71/db/scop.hhm /cluster/toolkit/production/databases/hhpred/new_dbs/pfamA_22.0/db/pfamA.hhm /cluster/toolkit/production/databases/hhpred/new_dbs/smart_18Apr07/db/smart.hhm /cluster/toolkit/production/databases/hhpred/new_dbs/pfam_18Apr07/db//pfam.hhm /cluster/toolkit/production/databases/hhpred/new_dbs/KOG_18Apr07/db/KOG.hhm /cluster/toolkit/production/databases/hhpred/new_dbs/COG_18Apr07/db/COG.hhm /cluster/toolkit/production/databases/hhpred/new_dbs/cd_18Apr07/db/cd.hhm /cluster/toolkit/production/databases/hhpred/new_dbs/panther_13Dec06/db/panther.hmm /cluster/toolkit/production/databases/hhpred/new_dbs/tigrfam_13Dec06/db/tigrfam.hmm /cluster/toolkit/production/databases/hhpred/new_dbs/pirsf_13Dec06/db/pirsf.hmm /cluster/toolkit/production/databases/hhpred/new_dbs/supfam_13Dec06/db/supfam.hmm /cluster/toolkit/production/databases/hhpred/new_dbs/CATH_13Dec06/db/CATH.hmm -o /cluster/toolkit/production/tmp/production/96219/An_XP_001391598.hhr -p 20 -P 20 -Z 100 -B 100 -seq 1 -aliw 80 -local -ssm 2 -norealign -sc 1 No Hit Prob E-value P-value Score SS Cols Query HMM Template HMM 1 pfam05783 DLIC Dynein light in 100.0 0 0 981.9 27.8 414 13-523 11-436 (475) 2 PF05783 DLIC: Dynein light in 100.0 0 0 928.4 29.7 415 13-523 11-465 (525) 3 KOG3905 Dynein light intermedi 100.0 0 0 906.4 27.8 398 21-523 24-434 (473) 4 PTHR12688 DYNEIN LIGHT INTERME 100.0 0 0 716.3 15.8 356 92-523 1-360 (415) 5 PTHR13236 DYNEIN 2 LIGHT INTER 99.3 7.4E-11 7.8E-16 93.0 9.1 283 17-324 2-306 (397) 6 KOG3929 Uncharacterized conser 99.1 1.9E-10 2E-15 90.4 3.9 235 46-324 45-282 (363) 7 2fg5_A RAB-22B, RAS-related pr 98.3 0.00012 1.3E-09 52.6 13.4 175 38-299 15-189 (192) 8 1x3s_A RAS-related protein RAB 98.2 3.6E-05 3.7E-10 56.0 9.8 173 44-303 13-185 (195) 9 d1r2qa_ c.37.1.8 (A:) Rab5a {H 98.2 0.00048 5E-09 48.7 14.5 162 41-287 1-162 (170) 10 e1x3sa1 c.37.1.8 (A:2-178) Rab 98.2 0.00011 1.1E-09 52.9 11.1 170 44-300 5-174 (177) 11 cd00154 Rab Rab family. Rab G 98.2 0.00025 2.6E-09 50.6 12.9 151 49-284 3-153 (159) 12 d3raba_ c.37.1.8 (A:) Rab3a {R 98.2 0.00036 3.8E-09 49.5 13.4 162 49-297 8-169 (169) 13 2q3h_A RAS homolog gene family 98.1 4.8E-05 5E-10 55.2 8.8 167 48-289 22-190 (201) 14 2hxs_A RAB-26, RAS-related pro 98.1 0.00056 5.8E-09 48.3 14.1 166 41-287 1-166 (178) 15 e1xtqa1 c.37.1.8 (A:3-169) GTP 98.1 0.00012 1.3E-09 52.5 10.7 159 45-289 3-162 (167) 16 e1z2aa_ c.37.1.8 (A:) Rab23 {M 98.1 0.00012 1.3E-09 52.6 10.6 151 48-284 4-154 (164) 17 e2erxa1 c.37.1.8 (A:6-176) di- 98.1 0.00026 2.7E-09 50.4 12.1 158 48-289 4-161 (171) 18 d1wmsa_ c.37.1.8 (A:) Rab9a {H 98.1 0.00086 8.9E-09 47.1 14.6 158 49-288 9-167 (174) 19 d1g16a_ c.37.1.8 (A:) Rab-rela 98.1 0.00049 5.1E-09 48.7 13.1 153 48-287 4-157 (166) 20 2j1l_A RHO-related GTP-binding 98.1 4.2E-05 4.3E-10 55.6 7.3 183 32-289 17-204 (214) 21 d1d5ca_ c.37.1.8 (A:) Rab6 {Ma 98.1 0.0013 1.3E-08 45.9 14.9 154 49-287 4-157 (162) 22 2p5s_A RAS and EF-hand domain 98.1 0.00015 1.5E-09 52.0 9.9 170 48-298 30-199 (199) 23 e2gjsa1 c.37.1.8 (A:91-258) Ra 98.1 0.00014 1.5E-09 52.2 9.8 154 49-289 4-158 (168) 24 1ek0_A GTP-binding protein YPT 98.1 0.00057 6E-09 48.2 12.9 158 48-287 5-162 (170) 25 1x1r_A RAS-related protein M-R 98.1 0.00046 4.9E-09 48.8 12.4 166 44-297 11-178 (178) 26 1xtq_A GTP-binding protein RHE 98.0 0.0012 1.3E-08 46.1 13.9 159 46-289 6-164 (177) 27 e1z06a1 c.37.1.8 (A:32-196) Ra 98.0 0.00044 4.6E-09 49.0 11.4 156 48-286 4-162 (165) 28 1wms_A RAB-9, RAB9, RAS-relate 98.0 0.0013 1.3E-08 45.9 13.7 166 49-298 10-176 (177) 29 2f9l_A RAB11B, member RAS onco 98.0 0.0012 1.2E-08 46.1 13.5 157 48-289 7-163 (199) 30 e1z08a1 c.37.1.8 (A:17-183) Ra 98.0 0.00045 4.7E-09 48.9 10.9 151 49-284 6-156 (167) 31 d1r2qa_ c.37.1.8 (A:) Rab5a {H 98.0 0.0022 2.3E-08 44.4 14.3 160 41-285 1-160 (170) 32 cd01868 Rab11_like Rab11-like. 98.0 0.0009 9.4E-09 46.9 12.3 155 49-289 6-161 (165) 33 cd00876 Ras Ras family. The R 97.9 0.00064 6.7E-09 47.9 11.5 152 49-286 2-154 (160) 34 cd04141 Rit_Rin_Ric Rit/Rin/Ri 97.9 0.00084 8.8E-09 47.1 11.8 168 49-303 5-172 (172) 35 1r2q_A RAS-related protein RAB 97.9 0.0024 2.5E-08 44.1 14.2 169 41-296 1-169 (170) 36 e1x1ra1 c.37.1.8 (A:10-178) Ra 97.9 0.00083 8.7E-09 47.2 11.8 161 44-289 2-163 (169) 37 2g3y_A GTP-binding protein GEM 97.9 0.0015 1.6E-08 45.4 13.2 174 33-289 24-198 (211) 38 2fn4_A P23, RAS-related protei 97.9 0.0019 2E-08 44.8 13.6 156 49-289 12-167 (181) 39 1oix_A RAS-related protein RAB 97.9 0.0012 1.3E-08 46.0 12.6 156 49-289 32-187 (191) 40 1ky3_A GTP-binding protein YPT 97.9 0.0016 1.7E-08 45.3 13.1 160 48-286 10-170 (182) 41 cd04113 Rab4 Rab4 subfamily. 97.9 0.00091 9.5E-09 46.9 11.7 151 49-284 3-153 (161) 42 1u8z_A RAS-related protein RAL 97.9 0.0016 1.7E-08 45.3 12.9 167 44-297 2-168 (168) 43 d1ky3a_ c.37.1.8 (A:) Rab-rela 97.9 0.0017 1.8E-08 45.2 12.8 162 48-287 4-165 (175) 44 2atx_A Small GTP binding prote 97.9 0.0014 1.5E-08 45.6 12.3 161 48-285 20-184 (194) 45 2dpx_A GTP-binding protein RAD 97.9 0.00036 3.8E-09 49.5 9.2 154 48-287 9-162 (174) 46 cd04122 Rab14 Rab14 subfamily. 97.8 0.0013 1.4E-08 45.8 11.7 152 49-286 5-157 (166) 47 e2atva1 c.37.1.8 (A:5-172) Ras 97.8 0.0015 1.5E-08 45.6 11.9 163 48-298 4-167 (168) 48 cd04101 RabL4 RabL4 (Rab-like4 97.8 0.0018 1.9E-08 44.9 12.4 153 49-284 3-155 (164) 49 2atv_A RERG, RAS-like estrogen 97.8 0.0029 3.1E-08 43.6 13.3 156 48-289 30-186 (196) 50 cd01866 Rab2 Rab2 subfamily. 97.8 0.0021 2.2E-08 44.5 12.3 152 49-286 7-159 (168) 51 e2f7sa1 c.37.1.8 (A:5-190) Rab 97.8 0.00072 7.6E-09 47.6 9.8 168 48-289 7-174 (186) 52 1m7b_A RND3/RHOE small GTP-bin 97.8 0.00076 7.9E-09 47.4 9.8 171 41-286 2-175 (184) 53 d1ek0a_ c.37.1.8 (A:) Ypt51 {B 97.8 0.0035 3.7E-08 43.1 13.1 155 48-284 5-159 (170) 54 d1wmsa_ c.37.1.8 (A:) Rab9a {H 97.8 0.004 4.2E-08 42.7 13.4 158 49-288 9-167 (174) 55 2oil_A CATX-8, RAS-related pro 97.8 0.0027 2.8E-08 43.9 12.2 152 49-285 28-179 (193) 56 1z2a_A RAS-related protein RAB 97.8 0.0037 3.9E-08 42.9 12.8 162 48-297 7-168 (168) 57 cd00877 Ran Ran (Ras-related n 97.8 0.0028 3E-08 43.7 12.2 159 49-296 3-166 (166) 58 d1c1ya_ c.37.1.8 (A:) Rap1A {H 97.8 0.0053 5.5E-08 42.0 13.5 157 48-289 5-162 (167) 59 2a9k_A RAS-related protein RAL 97.7 0.0054 5.7E-08 41.9 13.4 165 40-289 12-176 (187) 60 pfam00071 Ras Ras family. Incl 97.7 0.0029 3E-08 43.7 11.9 150 49-284 2-152 (162) 61 cd04140 ARHI_like ARHI subfami 97.7 0.0034 3.6E-08 43.2 12.2 153 49-284 4-156 (165) 62 2fv8_A H6, RHO-related GTP-bin 97.7 0.00068 7.1E-09 47.7 8.6 179 42-297 21-201 (207) 63 2bov_A RAla, RAS-related prote 97.7 0.0057 6E-08 41.7 13.3 156 49-289 17-172 (206) 64 1kao RAP2A; GTP-binding prot 97.7 0.005 5.2E-08 42.1 12.9 154 48-286 5-158 (167) 65 e2atxa1 c.37.1.8 (A:9-193) Rho 97.7 0.002 2.1E-08 44.7 10.7 163 48-285 11-175 (185) 66 d1g16a_ c.37.1.8 (A:) Rab-rela 97.7 0.0065 6.8E-08 41.3 13.3 153 48-287 4-157 (166) 67 1z06_A RAS-related protein RAB 97.7 0.0016 1.7E-08 45.2 10.2 153 49-284 23-175 (189) 68 2cjw_A GTP-binding protein GEM 97.7 0.0042 4.4E-08 42.6 12.3 158 49-289 9-167 (192) 69 2gf9_A RAS-related protein RAB 97.7 0.0083 8.7E-08 40.7 13.6 156 49-289 25-180 (189) 70 d1oiva_ c.37.1.8 (A:) Rab11a { 97.7 0.0044 4.6E-08 42.5 12.2 156 49-289 9-164 (168) 71 cd04127 Rab27A Rab27a subfamil 97.7 0.0044 4.6E-08 42.5 12.1 160 49-289 7-173 (180) 72 1z08_A RAS-related protein RAB 97.7 0.02 2.1E-07 38.1 15.5 164 41-289 1-164 (170) 73 1vg8_A RAS-related protein RAB 97.7 0.0097 1E-07 40.2 13.8 165 40-286 2-167 (207) 74 1gwn_A RHO-related GTP-binding 97.7 0.0013 1.4E-08 45.8 9.3 163 49-286 31-196 (205) 75 d1m7ba_ c.37.1.8 (A:) RhoE (RN 97.7 0.0023 2.4E-08 44.3 10.4 163 49-286 5-170 (179) 76 d1moza_ c.37.1.8 (A:) ADP-ribo 97.7 0.0012 1.2E-08 46.2 8.9 171 29-287 2-172 (182) 77 cd04110 Rab35 Rab35 subfamily. 97.7 0.0057 5.9E-08 41.7 12.4 151 49-286 9-160 (199) 78 1c1y_A RAS-related protein RAP 97.7 0.0093 9.7E-08 40.3 13.5 156 49-289 6-162 (167) 79 cd04119 RJL RJL (RabJ-Like) su 97.6 0.005 5.2E-08 42.1 11.9 156 49-284 3-158 (168) 80 e2a5ja1 c.37.1.8 (A:9-181) Rab 97.6 0.0027 2.8E-08 43.9 10.6 156 49-289 6-161 (173) 81 d3raba_ c.37.1.8 (A:) Rab3a {R 97.6 0.014 1.5E-07 39.2 14.2 156 49-289 8-163 (169) 82 2ce2_X GTPase HRAS; guanine nu 97.6 0.0075 7.8E-08 41.0 12.8 160 44-289 1-160 (166) 83 1yzq_A Small GTP binding prote 97.6 0.0083 8.7E-08 40.7 13.0 154 49-287 9-162 (170) 84 1i2m_A RAN, GTP-binding nuclea 97.6 0.0024 2.5E-08 44.2 10.1 150 49-286 13-162 (216) 85 d1m7ba_ c.37.1.8 (A:) RhoE (RN 97.6 0.0021 2.2E-08 44.6 9.8 163 49-286 5-170 (179) 86 cd04124 RabL2 RabL2 subfamily. 97.6 0.0054 5.7E-08 41.9 11.9 146 49-284 3-149 (161) 87 1z0j_A RAB-22, RAS-related pro 97.6 0.017 1.8E-07 38.7 14.4 154 48-286 8-161 (170) 88 d1ukvy_ c.37.1.8 (Y:) GTPase Y 97.6 0.01 1.1E-07 40.1 13.3 152 49-286 9-161 (204) 89 2gf0_A GTP-binding protein DI- 97.6 0.0038 4E-08 42.9 11.1 156 49-289 11-166 (199) 90 cd04160 Arfrp1 Arfrp1 subfamil 97.6 0.012 1.2E-07 39.7 13.5 162 48-286 1-162 (167) 91 d1kao__ c.37.1.8 (-) Rap2a {Hu 97.6 0.0087 9.1E-08 40.5 12.8 157 48-289 5-161 (167) 92 2nzj_A GTP-binding protein REM 97.6 0.0075 7.8E-08 41.0 12.4 155 49-287 7-162 (175) 93 cd04123 Rab21 Rab21 subfamily. 97.6 0.0081 8.4E-08 40.7 12.2 151 49-284 3-153 (162) 94 cd04125 RabA_like RabA-like su 97.6 0.0088 9.1E-08 40.5 12.2 150 49-284 3-153 (188) 95 cd04128 Spg1 Spg1p. Spg1p (se 97.6 0.014 1.5E-07 39.2 13.3 155 49-284 3-157 (182) 96 1ksh_A ARF-like protein 2; sma 97.6 0.0028 3E-08 43.7 9.7 155 48-289 20-175 (186) 97 1zd9_A ADP-ribosylation factor 97.6 0.0021 2.1E-08 44.6 9.0 181 32-299 3-188 (188) 98 cd04159 Arl10_like Arl10-like 97.6 0.0035 3.7E-08 43.1 10.2 153 48-286 1-154 (159) 99 cd04136 Rap_like Rap-like subf 97.5 0.0052 5.5E-08 42.0 11.0 151 49-284 4-154 (163) 100 2rex_B RHO-related GTP-binding 97.5 0.0011 1.2E-08 46.3 7.5 164 48-286 12-178 (197) No 1 >pfam05783 DLIC Dynein light intermediate chain (DLIC). This family consists of several eukaryotic dynein light intermediate chain proteins. The light intermediate chains (LICs) of cytoplasmic dynein consist of multiple isoforms, which undergo post-translational modification to produce a large number of species. DLIC1 is known to be involved in assembly, organisation, and function of centrosomes and mitotic spindles when bound to pericentrin. DLIC2 is a subunit of cytoplasmic dynein 2 that may play a role in maintaining Golgi organisation by binding cytoplasmic dynein 2 to its Golgi-associated cargo. Probab=100.00 E-value=0 Score=981.95 Aligned_columns=414 Identities=31% Q ss_pred CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCC--CCC-EEEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 4668887777777502377898887664048--842-0478864779873212323311112455663122565674444 Q Fun_An_XP_0013 13 GTGNNSRPSSKDGPKKNIWSSMLDSVANGKR--LPE-KNLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVAN 89 (523) Q Consensus 13 ~~~~~~~~~~~d~~k~nLWssiL~~vss~~r--lps-KnilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~ 89 (523) ..+.....-+.+++|||||+|||++|++++| ||+ |||||||++++||||||++|++.+ +.+||+ T Consensus 11 ~~~~~~~~~~~~~~k~nLWsSIL~~V~t~~r~Klp~~KniLVLG~~~~GKttLl~~Lqg~~-------~~kkg~------ 77 (475) T pfam05783 11 ASVFTGKLYSSTEEGQNLWSEILSEVSTRTRSKLPSGKNVLVLGDNGSGKTSLISRLQGSE-------RTKKGR------ 77 (475) T ss_pred HHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCC-------CCCCCC------ T ss_conf 3320267777410122478988865302533347776647885089975578999750577-------667863------ Q ss_pred CCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHHHHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHH Q ss_conf 33420223310006774551101678717887112320011058101200334333000031368999999999999998 Q Fun_An_XP_0013 90 QFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLLKPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVL 169 (523) Q Consensus 90 ~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LLk~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi 169 (523) ||||+|+||+|+|+|| ++||+|||| ++++||++||||||+++||+||||||+|||++||+||+||++|++|||+|+ T Consensus 78 --aL~Y~YldV~DeD~Dd-~~R~~vwiL-d~~~~~~~LLK~aL~~~si~~TlViI~lDms~PW~~i~qL~~Wi~VLrehi 153 (475) T pfam05783 78 --GLEYLYLHVHDEDRDD-LTRCNVWIL-DGDLYHKGLLKFALPATSLAETLVILTASMSNPWTLLESLQKWASVLREHI 153 (475) T ss_pred --CCCEEEECCCCCCHHH-HCCCCEEEC-CCCCCCCCCCCCCCCCCCHHHHHEHHHHHHHHHHHHHHHHHHHHHHHHHHH T ss_conf --1013463232203032-215424760-875152223212577231422012001212013489999999999999999 Q ss_pred HHCC---CCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC-----CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHH Q ss_conf 5069---5888999999999862268876777776777766-----4532136888753267895079996187556788 Q Fun_An_XP_0013 170 ISLD---DETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS-----AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKL 241 (523) Q Consensus 170 ~sL~---~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s-----~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~L 241 (523) ++|+ ++.+++|+++|+.||+|+++++..++.++++++. +++|.||||||+||+||||||||||||||+|++| T Consensus 154 ~~L~i~~ee~~el~e~l~~~wqeY~epg~~~d~s~~r~t~~~~~~~~~~v~lPLgeg~Lt~NLGiPiiVVctKsD~ie~L 233 (475) T pfam05783 154 DKLKIPPEEMKAGRQKLEKDWQEYVEPGEDLDGSPQRRTSVVGSFDEEHVLLPLGQDTLTHNLGLPVLVVCTKCDAMSVL 233 (475) T ss_pred HHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCEEEEEEEECCCHHHHH T ss_conf 71389988999999999999998605534678776324566565344456577887634127882699986176213333 Q ss_pred HHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHCCCCCCC-CCCCCCCCCCCCCEEEECCCCCHHH Q ss_conf 863588556899999999999987184125521233210345655322532246-6755112311462457468988214 Q Fun_An_XP_0013 242 EKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIHSSLGIHSLL-KRQSLKHNVIDRDKILVPSNWDSWG 320 (523) Q Consensus 242 EKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh~~lgih~ll-~~~~~~a~vverDav~VPaGWDsw~ 320 (523) |||||||||||||||||||||||||||||||||+|+++|| +|+|+|+ +|++| +.+..+++|||||+||||||||||| T Consensus 234 EKe~~ykeE~fDfIqq~LR~~cLqYGAsLiYTS~ke~kNl-dlLykYl-~HrlYgfpf~~~a~VvekDaIfIPsGWDn~k 311 (475) T pfam05783 234 EKEHDYRDEHFDFIQSHLRKFCLQYGAALIYTSVKETKNI-DLLYKYI-VHRSYGFPFTTPALVVEKDAVFIPAGWDNEK 311 (475) T ss_pred HCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCH-HHHHHHH-HHHHHCCCCCCCCCEEEHHEEEECCCCCCHH T ss_conf 2015664367999999999999870975898547764238-9999999-9886076545622001000034058888145 Q ss_pred HEEEECCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCEEHHHHHCCCCCCCCCCCCCCCCCCCCE Q ss_conf 10220047660212121221201341001577655566766555566653201000211047877632222100025650 Q Fun_An_XP_0013 321 KIRIIREGFDMEGISTAWSIEIQDPPEPLTNGVDDRSSDEQTANAVDDGTSAVAIFEQTIQDPKRDTSMALTGSQRNGNK 400 (523) Q Consensus 321 KI~IL~E~Fd~~~v~~~Ws~d~~~p~~~~~~~~~d~~~~~~~~~~~~d~~sa~~~ye~~I~dP~~~~~~~~~~~~~~~~~ 400 (523) ||+|||||| ....++|. ||++|.+|++++.+|.. T Consensus 312 KI~Il~Enf--------------------------------~~~k~~~~------~ed~i~kp~~rk~~~~~-------- 345 (475) T pfam05783 312 KIDILHENF--------------------------------PTVKAEDA------YEDIITKPPVRKVVHEK-------- 345 (475) T ss_pred HHHHHHCCC--------------------------------CCCCCCCC------CCCCCCCCCCHHHHHHH-------- T ss_conf 567543365--------------------------------43578764------22344788402333333-------- Q ss_pred EEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCHHHHHCCCCCCC Q ss_conf 24304733889999999999843788620024667876677766777643235750221465223531676620001467 Q Fun_An_XP_0013 401 IEVDTSDMQSFLTKQLEVLEQLKAEDEKDRAAKKVPQLEMSPLDDNGRVNEHIGPVQFNMGGIQVDADDMLRKLKEREAS 480 (523) Q Consensus 401 iev~t~D~Q~FL~kQ~~iL~~~~~~~~~~~~~~~~~~~~~sp~~~~~~v~e~iGPvqfnmGGiqvdad~~l~rlk~r~a~ 480 (523) ||++||+|+||+|||++|.+ +.+....+|.++++.-+-++.| |.....++ T Consensus 346 -ei~aeddQ~Fl~k~q~~l~~------------~~~~~~~~~~~~~~~~~p~~~~-----------------~~~~~~~~ 395 (475) T pfam05783 346 -EIEAEDDQAFLMKLQSILAK------------QPTTAAPRPLRSQGVGSPRTMP-----------------RTPGTVGQ 395 (475) T ss_pred -HHCCCHHHHHHHHHHHHHCC------------CCCCCCCCCCCCCCCCCCCCCC-----------------CCCCCCCC T ss_conf -20001278999999999716------------7877777755677788874577-----------------45542366 Q ss_pred CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCC Q ss_conf 7888777666778875317899999986503888886788889 Q Fun_An_XP_0013 481 RSQRKETLSSSAGDEKAHNQALANFFAGLVKKPGASPRGSPSA 523 (523) Q Consensus 481 ~s~~~~~~~~~~~~~~~~n~~LanFF~~Ll~k~~~s~rg~p~~ 523 (523) .+|.+-..+...+.... .++||||||+||+||+||| |+|+. T Consensus 396 ~~p~kk~dp~~~~~~~~-egvlanffnsll~kk~~sp-~~~~~ 436 (475) T pfam05783 396 SSPTKKIDPNLKATAGS-EGVLANFFNSLLSKKTGSP-GKPGP 436 (475) T ss_pred CCCCCCCCCCCCCCCCC-CHHHHHHHHHHHHCCCCCC-CCCCC T ss_conf 67764667775788643-1157777776630357888-88888 No 2 >PF05783 DLIC: Dynein light intermediate chain (DLIC); InterPro: IPR008467 This family consists of several eukaryotic dynein light intermediate chain proteins. The light intermediate chains (LICs) of cytoplasmic dynein consist of multiple isoforms, which undergo post-translational modification to produce a large number of species. DLIC1 is known to be involved in assembly, organisation, and function of centrosomes and mitotic spindles when bound to pericentrin. DLIC2 is a subunit of cytoplasmic dynein 2 that may play a role in maintaining Golgi organisation by binding cytoplasmic dynein 2 to its Golgi-associated cargo .; GO: 0003774 motor activity Probab=100.00 E-value=0 Score=928.39 Aligned_columns=415 Identities=33% Q ss_pred CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCC--CCC-EEEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCC Q ss_conf 4668887777777502377898887664048--842-0478864779873212323311112455663122565674444 Q Fun_An_XP_0013 13 GTGNNSRPSSKDGPKKNIWSSMLDSVANGKR--LPE-KNLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVAN 89 (523) Q Consensus 13 ~~~~~~~~~~~d~~k~nLWssiL~~vss~~r--lps-KnilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~ 89 (523) +++......+++++++|||++||+||+++++ ||+ |||||||++++||++||++|++++ +.+||| T Consensus 11 ~~~~~~~~~~~~~e~~~lWs~iL~evst~~~sklp~gk~vlVLGd~~sGKttLlakLqg~e-------~~~Kg~------ 77 (525) T PF05783_consen 11 TSSATAALKSEEEEKENLWSSILSEVSTRSNSKLPSGKNVLVLGDNGSGKTTLLAKLQGVE-------ETKKGR------ 77 (525) T ss_pred CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCC-------CCCCCC------ T ss_conf 4434344453023543388999887541245105788616886178876789999872344-------344676------ Q ss_pred CCCC-CEEEEEEEECCCC-----------------CCCCEEEEEEECCCCHHHHHHHHHCCCHHHHCCEEEEEEECCCCH Q ss_conf 3342-0223310006774-----------------551101678717887112320011058101200334333000031 Q Fun_An_XP_0013 90 QFAL-GYTYQDVLDADHE-----------------DTLARVSAYLLSEPSLSFAPLLKPLLTPQSIPETLVVILLDWSDP 151 (523) Q Consensus 90 ~~~L-gY~Y~dV~D~D~e-----------------D~~aR~svyiL~d~d~~~~~LLk~al~~~sl~~TLVvIvlDwS~P 151 (523) || ||+|+||+|+|+| |. +||||||| ||+++|++||||||++++|+||||||++||++| T Consensus 78 --gLleY~yl~v~dd~RD~~~~~~~~~~~~~~~p~d~-tR~nVWiL-dGd~~h~~LLKfAl~~~s~~~tlvilt~dms~P 153 (525) T PF05783_consen 78 --GLLEYLYLNVHDDDRDASYAYQLGTAGANLNPSDL-TRLNVWIL-DGDAYHKGLLKFALNAESIADTLVILTLDMSRP 153 (525) T ss_pred --CCCCEEEEEEEHHHHHHHHHHHCCCCCCCCCCCCC-CCCCEEEE-CCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCH T ss_conf --41113465311010121210000000011233310-11551576-175255555444368544034588887531010 Q ss_pred HHHHHHHHHHHHHHHHHHHHCCCCHHHH---HHHHHHHHHHCCCCCCCCCCCCCCC-----CCCCCCCCCCCCCCCCCCC Q ss_conf 3689999999999999985069588899---9999999862268876777776777-----7664532136888753267 Q Fun_An_XP_0013 152 WTWIRRLREWVRLLRHVLISLDDETKIV---MEENLTEWRDRKRGMDSSSGGAQGF-----TSSAGPVTIPLGPGEWDEG 223 (523) Q Consensus 152 Wt~me~L~~W~~vLr~hi~sL~~e~~~~---mee~~~~~~e~~~~~~~~~~~~~~~-----~~s~~~v~lPLg~g~lt~n 223 (523) |+||++|++|++|||+||++|+++.+++ ++++++.||+|+++++..+.+++++ ..+++.|.||||+|+||+| T Consensus 154 W~~mesLqkW~~Vl~ehi~kLki~~E~~~~meqrl~k~~QeY~EP~~~~~~sPqrr~~~~~s~~de~v~LPL~~g~Lt~N 233 (525) T PF05783_consen 154 WNLMESLQKWASVLREHIDKLKIPPEELKEMEQRLVKKFQEYVEPGEDLDGSPQRRTTVVSSSDDESVLLPLGEGTLTEN 233 (525) T ss_pred HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC T ss_conf 35899999999999999960578989999999999998764316133688884105677875443323266886641147 Q ss_pred CCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHCCCCCCC-CCCCCCC Q ss_conf 895079996187556788863588556899999999999987184125521233210345655322532246-6755112 Q Fun_An_XP_0013 224 LGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIHSSLGIHSLL-KRQSLKH 302 (523) Q Consensus 224 LGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh~~lgih~ll-~~~~~~a 302 (523) |||||||||||||+|++||||||||||||||||||||||||||||+|||||+|+++|| +|+|+|+ .|.|| +.+..++ T Consensus 234 LGipi~VVctk~D~i~~LeKe~d~kdE~fDfIqq~lR~fcL~yGAsLiYTSvKe~kN~-dllykYi-~HrlYgf~f~~~a 311 (525) T PF05783_consen 234 LGIPIIVVCTKSDAISVLEKEHDYKDEHFDFIQQHLRRFCLQYGASLIYTSVKEEKNI-DLLYKYI-VHRLYGFPFKTPA 311 (525) T ss_pred CCCEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCH-HHHHHHH-HHHHCCCCCCCCC T ss_conf 8951799850775134444204752778999999999999760740467404552108-9999999-8876077557743 Q ss_pred CCCCCCEEEECCCCCHHHHEEEECCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCEEHHHHHCCC Q ss_conf 31146245746898821410220047660212121221201341001577655566766555566653201000211047 Q Fun_An_XP_0013 303 NVIDRDKILVPSNWDSWGKIRIIREGFDMEGISTAWSIEIQDPPEPLTNGVDDRSSDEQTANAVDDGTSAVAIFEQTIQD 382 (523) Q Consensus 303 ~vverDav~VPaGWDsw~KI~IL~E~Fd~~~v~~~Ws~d~~~p~~~~~~~~~d~~~~~~~~~~~~d~~sa~~~ye~~I~d 382 (523) .|||||+|||||||||.+||.|||||| ....+||. ||++|.+ T Consensus 312 ~vvekdavfiPaGwDn~kKI~Il~En~--------------------------------~~~K~dd~------~ed~i~k 353 (525) T PF05783_consen 312 QVVEKDAVFIPAGWDNLKKISILHENF--------------------------------QTVKPDDP------YEDIITK 353 (525) T ss_pred EEEECCCEEECCCCCCHHHHHHHHHCC--------------------------------CCCCCCCC------CCCCCCC T ss_conf 034100012036765113334432033--------------------------------44666543------2332126 Q ss_pred CCCCCCCC--CCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECC Q ss_conf 87763222--2100025650243047338899999999998437886200246678766777667776432357502214 Q Fun_An_XP_0013 383 PKRDTSMA--LTGSQRNGNKIEVDTSDMQSFLTKQLEVLEQLKAEDEKDRAAKKVPQLEMSPLDDNGRVNEHIGPVQFNM 460 (523) Q Consensus 383 P~~~~~~~--~~~~~~~~~~iev~t~D~Q~FL~kQ~~iL~~~~~~~~~~~~~~~~~~~~~sp~~~~~~v~e~iGPvqfnm 460 (523) |++++.+| .. ||++||+|+||+|||++|.++.+.........+.+....+| |...+.||... T Consensus 354 pp~rk~v~~re~---------ei~aEddQ~FL~k~qs~La~q~~t~~~~p~~s~~r~~~gsp-----rt~~rs~~~~~-- 417 (525) T PF05783_consen 354 PPVRKLVHNREK---------EIQAEDDQVFLMKQQSLLAKQPPTAAGRPLDSSSRAPSGSP-----RTPNRSGPSNV-- 417 (525) T ss_pred CCCCCHHHHHHH---------HHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC-----CCCCCCCCCCC-- T ss_conf 863300112245---------54112068999999998614787777765555677788887-----77876566666-- Q ss_pred CCCCCCCCHHHHHCCCCCCCCCC-----CCCCC--CCCCCCCCCCHHHHHHHHHHHHCC-CCCCCCCCCCC Q ss_conf 65223531676620001467788-----87776--667788753178999999865038-88886788889 Q Fun_An_XP_0013 461 GGIQVDADDMLRKLKEREASRSQ-----RKETL--SSSAGDEKAHNQALANFFAGLVKK-PGASPRGSPSA 523 (523) Q Consensus 461 GGiqvdad~~l~rlk~r~a~~s~-----~~~~~--~~~~~~~~~~n~~LanFF~~Ll~k-~~~s~rg~p~~ 523 (523) |+.+| .+..| .+++..|++ ||||||+||+| |+||| |+|++ T Consensus 418 ------------------~~~sP~~~~~kK~dPn~~~~~~~Egv----LANFFnSLLsKdKtgsP-g~~~~ 465 (525) T PF05783_consen 418 ------------------AQVSPIMAGTKKPDPNIKATASSEGV----LANFFNSLLSKDKTGSP-GSPGT 465 (525) T ss_pred ------------------CCCCCCCCCCCCCCCCCCCCCCCCHH----HHHHHHHHHHHCCCCCC-CCCCC T ss_conf ------------------65565555566778654567532026----78888876520246788-88776 No 3 >KOG3905 Dynein light intermediate chain [Cell motility] Probab=100.00 E-value=0 Score=906.45 Aligned_columns=398 Identities=31% Q ss_pred CCCCCCHHHHHHHHHHHHHHHCC--CCC-EEEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEE Q ss_conf 77777502377898887664048--842-047886477987321232331111245566312256567444433420223 Q Fun_An_XP_0013 21 SSKDGPKKNIWSSMLDSVANGKR--LPE-KNLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTY 97 (523) Q Consensus 21 ~~~d~~k~nLWssiL~~vss~~r--lps-KnilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y 97 (523) +.+++++||||++||+||+++.| ||+ |||||||++++||++||.+|++.+ +.+||+ ||||.| T Consensus 24 ~~deeegqnlWs~iLsev~T~~~sklpsgk~VlvlGdn~sGKtsLi~klqg~e-------~~Kkgs--------gLeY~y 88 (473) T KOG3905 24 STDEEEGQNLWSEILSEVSTRTRSKLPSGKNVLVLGDNGSGKTSLISKLQGSE-------TVKKGS--------GLEYLY 88 (473) T ss_pred CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCC-------CCCCCC--------CCEEEE T ss_conf 45356778999999865420123447788657997058874578988763024-------567765--------312678 Q ss_pred EEEEECCCCCCCCEEEEEEECCCCHHHHHHHHHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHH Q ss_conf 31000677455110167871788711232001105810120033433300003136899999999999999850695888 Q Fun_An_XP_0013 98 QDVLDADHEDTLARVSAYLLSEPSLSFAPLLKPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETK 177 (523) Q Consensus 98 ~dV~D~D~eD~~aR~svyiL~d~d~~~~~LLk~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~ 177 (523) ++|+|+||||. +||+||+| |||+||++||||||++.|+++||||+++||++||+||+||++|++|+|+||++++++++ T Consensus 89 l~V~de~RDd~-tr~~VWiL-DGd~~h~~LLk~al~ats~aetlviltasms~Pw~~lesLqkWa~Vl~ehidkl~i~~e 166 (473) T KOG3905 89 LHVHDEDRDDL-TRCNVWIL-DGDLYHKGLLKFALPATSLAETLVILTASMSNPWTLLESLQKWASVLREHIDKLKIPPE 166 (473) T ss_pred EEECCCCHHHH-HHCCCEEE-CCCHHHHHHHHHCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCHH T ss_conf 86213100446-54871487-18755521243204655615458989986575035899999999999998986258989 Q ss_pred HH---HHHHHHHHHHCCCCCCCCCCCCCCCCCC-----CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCH Q ss_conf 99---9999999862268876777776777766-----453213688875326789507999618755678886358855 Q Fun_An_XP_0013 178 IV---MEENLTEWRDRKRGMDSSSGGAQGFTSS-----AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHE 249 (523) Q Consensus 178 ~~---mee~~~~~~e~~~~~~~~~~~~~~~~~s-----~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykd 249 (523) ++ +++..+.||+|+++++..+.+++++++. |+++.||||+++||||||||++|||||||+|++|||||+||| T Consensus 167 e~ka~rqk~~k~wQeYvep~e~~pgsp~~r~t~~~~~~de~~llPL~~dtLt~NlGi~vlVV~TK~D~~s~leke~eyrD 246 (473) T KOG3905 167 EMKAGRQKLEKDWQEYVEPGEDQPGSPQRRTTVVGSSADEHVLLPLGQDTLTHNLGIPVLVVCTKCDAVSVLEKEHEYRD 246 (473) T ss_pred HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCEEEEEECCCHHHHHHHCCCCCH T ss_conf 99999999888889760512478888620343335655311112267762000068747999842430334552010016 Q ss_pred HHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHCC--CCCCCCCCCCCCCCCCCCEEEECCCCCHHHHEEEECC Q ss_conf 68999999999999871841255212332103456553225--3224667551123114624574689882141022004 Q Fun_An_XP_0013 250 EQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIHSSLG--IHSLLKRQSLKHNVIDRDKILVPSNWDSWGKIRIIRE 327 (523) Q Consensus 250 E~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh~~lg--ih~ll~~~~~~a~vverDav~VPaGWDsw~KI~IL~E 327 (523) |||||||||||+|||+|||+|||||+||.||+ +|+|+|+. ++.+.|+.| |.|||||||||||||||.|||.|||| T Consensus 247 ehfdfiq~~lRkFCLr~GaaLiyTSvKE~KNi-dllyKYivhr~yG~~fttp--AlVVEkdaVfIPAGWD~eKKI~Il~E 323 (473) T KOG3905 247 EHFDFIQSHLRKFCLRYGAALIYTSVKETKNI-DLLYKYIVHRSYGFPFTTP--ALVVEKDAVFIPAGWDNEKKIDILHE 323 (473) T ss_pred HHHHHHHHHHHHHHHHCCCEEEEEECCCCCCH-HHHHHHHHHHHCCCCCCCH--HHEEECCEEEECCCCCCCCHHHHHHC T ss_conf 78999999999999860630255411124556-8888888876415531350--01232031463046686300221000 Q ss_pred CCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCEEHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCC Q ss_conf 76602121212212013410015776555667665555666532010002110478776322221000256502430473 Q Fun_An_XP_0013 328 GFDMEGISTAWSIEIQDPPEPLTNGVDDRSSDEQTANAVDDGTSAVAIFEQTIQDPKRDTSMALTGSQRNGNKIEVDTSD 407 (523) Q Consensus 328 ~Fd~~~v~~~Ws~d~~~p~~~~~~~~~d~~~~~~~~~~~~d~~sa~~~ye~~I~dP~~~~~~~~~~~~~~~~~iev~t~D 407 (523) || ..+..+|. ||++|.+|++++.+|.. ||++|| T Consensus 324 n~--------------------------------~~vkaed~------y~d~itkpp~Rk~v~ek---------ei~aEd 356 (473) T KOG3905 324 NF--------------------------------PTVKAEDN------YEDIITKPPVRKVVHEK---------EIEAED 356 (473) T ss_pred CC--------------------------------CCCCCCCC------CCCCCCCCCCHHHHHHH---------HHHHHH T ss_conf 35--------------------------------67787765------33243688401566666---------541013 Q ss_pred HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCHHHHHCCCCCCCCCCCCCC Q ss_conf 38899999999998437886200246678766777667776432357502214652235316766200014677888777 Q Fun_An_XP_0013 408 MQSFLTKQLEVLEQLKAEDEKDRAAKKVPQLEMSPLDDNGRVNEHIGPVQFNMGGIQVDADDMLRKLKEREASRSQRKET 487 (523) Q Consensus 408 ~Q~FL~kQ~~iL~~~~~~~~~~~~~~~~~~~~~sp~~~~~~v~e~iGPvqfnmGGiqvdad~~l~rlk~r~a~~s~~~~~ 487 (523) +|+||+|||+||.+.+.......-..+.+..+.|| |...|..+.||-+.+ T Consensus 357 dQaFL~k~q~iLak~~~t~a~rp~~sq~~~~~ksp------------------------------rtpg~~g~sSP~k~~ 406 (473) T KOG3905 357 DQAFLMKLQSILAKQPTTAAPRPRTSQERGPDKSP------------------------------RTPGRSGSSSPLKKS 406 (473) T ss_pred HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC------------------------------CCCCCCCCCCCCCCC T ss_conf 78999999998605888888786546788878887------------------------------678887666788888 Q ss_pred CCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCC Q ss_conf 666778875317899999986503888886788889 Q Fun_An_XP_0013 488 LSSSAGDEKAHNQALANFFAGLVKKPGASPRGSPSA 523 (523) Q Consensus 488 ~~~~~~~~~~~n~~LanFF~~Ll~k~~~s~rg~p~~ 523 (523) .+.+.+ .||||||+||+||+||| |+|-| T Consensus 407 ~P~seg-------Vlasffnsll~kktgsp-g~~g~ 434 (473) T KOG3905 407 DPTSEG-------VLASFFNSLLSKKTGSP-GGPGA 434 (473) T ss_pred CCHHHH-------HHHHHHHHHHHHCCCCC-CCCCC T ss_conf 850246-------78999998864126888-88888 No 4 >PTHR12688 DYNEIN LIGHT INTERMEDIATE CHAIN; InterPro: IPR008467 This family consists of several eukaryotic dynein light intermediate chain proteins. The light intermediate chains (LICs) of cytoplasmic dynein consist of multiple isoforms, which undergo post-translational modification to produce a large number of species. DLIC1 is known to be involved in assembly, organisation, and function of centrosomes and mitotic spindles when bound to pericentrin. DLIC2 is a subunit of cytoplasmic dynein 2 that may play a role in maintaining Golgi organisation by binding cytoplasmic dynein 2 to its Golgi-associated cargo .; GO: 0003774 motor activity. Probab=100.00 E-value=0 Score=716.27 Aligned_columns=356 Identities=32% Q ss_pred CCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHHHHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHH Q ss_conf 42022331000677455110167871788711232001105810120033433300003136899999999999999850 Q Fun_An_XP_0013 92 ALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLLKPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLIS 171 (523) Q Consensus 92 ~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LLk~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~s 171 (523) ||+|+|++|+|+|++|. +||+||+| ||+++|++|||||++++|+|+|||+|++||++||+||+|||+|++|||+|+++ T Consensus 1 g~~Y~y~~v~d~d~d~~-~r~~vW~L-dgd~~~~gLlk~a~~~~s~~~tl~~~~~dm~~PW~~~~~L~~W~~v~~~~~~k 78 (415) T PTHR12688 1 GLEYLYLNVHDEDRDDL-TRCNVWIL-DGDLYHKGLLKFALSAESLPDTLVILVADMSKPWTVMDSLQKWASVLREHIDK 78 (415) T ss_pred CCCHHHHHHHHCCHHHH-HHCCCEEE-CCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH T ss_conf 92013220110360134-32101034-35276777888631730178999999998722557999999999999999987 Q ss_pred CCCCHHHH---HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCC Q ss_conf 69588899---999999986226887677777677776645321368887532678950799961875567888635885 Q Fun_An_XP_0013 172 LDDETKIV---MEENLTEWRDRKRGMDSSSGGAQGFTSSAGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWH 248 (523) Q Consensus 172 L~~e~~~~---mee~~~~~~e~~~~~~~~~~~~~~~~~s~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dyk 248 (523) |.+.+.++ |++.+..||+|.++++.....+..... ++.+.|||++++||+|||+|++|||||||.|+.|||||||| T Consensus 79 l~i~~~~~~~~~~~~~~~~q~y~e~~~~~~~s~~~~~~-d~~~~lp~~~~~lt~nlG~~~~vV~~k~d~~~~L~ke~dyr 157 (415) T PTHR12688 79 LKIPPEEMKELEQKLVKDFQEYVEPGEGLPGSPLRRNA-DELVPLPLGEGTLTHNLGIPVVVVCTKSDAMSVLEKEHDYR 157 (415) T ss_pred HCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHH-HHHHHCCCCHHHHHHHCCCEEEEEEECCHHHHHHHHHCCCH T ss_conf 33888899999999999754210200133334201123-44431234124677637916999874131578875430312 Q ss_pred HHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHCCCCCCC-CCCCCCCCCCCCCEEEECCCCCHHHHEEEECC Q ss_conf 56899999999999987184125521233210345655322532246-67551123114624574689882141022004 Q Fun_An_XP_0013 249 EEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIHSSLGIHSLL-KRQSLKHNVIDRDKILVPSNWDSWGKIRIIRE 327 (523) Q Consensus 249 dE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh~~lgih~ll-~~~~~~a~vverDav~VPaGWDsw~KI~IL~E 327 (523) ||||||||++||+|||||||+|||||+||.+|| +|||+|+ +|.+| +.+..+|.||||||||||||||+++||+|||| T Consensus 158 dehfDfiq~~lR~fcL~yga~L~ytsvke~kN~-dLlykYi-vh~~yGf~f~~~a~VvekdavfiPaGWD~~kKI~il~e 235 (415) T PTHR12688 158 DEHFDFIQSHLRKFCLQYGAALIYTSVKEEKNI-DLLYKYI-VHKLYGFPFTIPALVVEKDAVFIPAGWDNEKKIGILHE 235 (415) T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-HHHHHHH-HHHHCCCCCCCHHHEEEEEEEEECCCCCCHHHHHHHHC T ss_conf 889999999999999984025311010013348-9999999-88860654344011122000451689880778898760 Q ss_pred CCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCEEHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCC Q ss_conf 76602121212212013410015776555667665555666532010002110478776322221000256502430473 Q Fun_An_XP_0013 328 GFDMEGISTAWSIEIQDPPEPLTNGVDDRSSDEQTANAVDDGTSAVAIFEQTIQDPKRDTSMALTGSQRNGNKIEVDTSD 407 (523) Q Consensus 328 ~Fd~~~v~~~Ws~d~~~p~~~~~~~~~d~~~~~~~~~~~~d~~sa~~~ye~~I~dP~~~~~~~~~~~~~~~~~iev~t~D 407 (523) || ....++|. ||+.|.+|+.|+.+|.+ |+.+|| T Consensus 236 nf--------------------------------~~~~~~d~------y~d~i~~P~~Rk~v~~~---------~~~aed 268 (415) T PTHR12688 236 NF--------------------------------TTVKPEDA------YEDIIVKPPVRKLVHEK---------EIAAED 268 (415) T ss_pred CC--------------------------------CCCCCCCC------CCCCCCCCCCCHHHHHH---------HHHHHH T ss_conf 52--------------------------------00244421------01102578501234588---------875446 Q ss_pred HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCHHHHHCCCCCCCCCCCCCC Q ss_conf 38899999999998437886200246678766777667776432357502214652235316766200014677888777 Q Fun_An_XP_0013 408 MQSFLTKQLEVLEQLKAEDEKDRAAKKVPQLEMSPLDDNGRVNEHIGPVQFNMGGIQVDADDMLRKLKEREASRSQRKET 487 (523) Q Consensus 408 ~Q~FL~kQ~~iL~~~~~~~~~~~~~~~~~~~~~sp~~~~~~v~e~iGPvqfnmGGiqvdad~~l~rlk~r~a~~s~~~~~ 487 (523) +|+||+||+++|.+.+..+.+...+ +.+....|| +-..+-||.. +.......++...+... T Consensus 269 ~Q~fl~k~~~~l~~~~~~~~~~~e~-p~r~~~~S~-----~~~~~~~~~~-------------~~~~~~~~~~~~k~d~~ 329 (415) T PTHR12688 269 EQVFLMKQQSLLAKQPATPTRTSES-PARGPGGSP-----RTQGRGGPAS-------------VPSASPGTASVKKPDPN 329 (415) T ss_pred HHHHHHHHHHHHHHCCCCCCCCCCC-CCCCCCCCC-----CCCCCCCCCC-------------CCCCCCCCCCCCCCCCC T ss_conf 7789999999985212321100001-112566654-----4567776542-------------21102345555544521 Q ss_pred CCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCC Q ss_conf 666778875317899999986503888886788889 Q Fun_An_XP_0013 488 LSSSAGDEKAHNQALANFFAGLVKKPGASPRGSPSA 523 (523) Q Consensus 488 ~~~~~~~~~~~n~~LanFF~~Ll~k~~~s~rg~p~~ 523 (523) .......++. |||||++|++|++||+ |+|++ T Consensus 330 ~~~~~~~~g~----la~ffn~Ll~k~~gs~-g~~~~ 360 (415) T PTHR12688 330 LKNNAASEGV----LANFFNSLLSKKTGSP-GSPGA 360 (415) T ss_pred CCCCCCHHHH----HHHHHHHHHHCCCCCC-CCCCC T ss_conf 0034301125----6777765531035788-87654 No 5 >PTHR13236 DYNEIN 2 LIGHT INTERMEDIATE CHAIN, ISOFORM 2. Probab=99.27 E-value=7.4e-11 Score=92.99 Aligned_columns=283 Identities=18% Q ss_pred CCCCCCCCCCHHHHHHHHHHHHHHHCC---------CCCEEEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCC Q ss_conf 887777777502377898887664048---------84204788647798732123233111124556631225656744 Q Fun_An_XP_0013 17 NSRPSSKDGPKKNIWSSMLDSVANGKR---------LPEKNLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPV 87 (523) Q Consensus 17 ~~~~~~~d~~k~nLWssiL~~vss~~r---------lpsKnilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppi 87 (523) ...+...+-+-+.||.---.+|..+.. ..+|.|.++|-...||+|++-.. -+.....+|.. T Consensus 2 ~~~~~~~~~~~e~lw~~A~~~~e~rg~~g~~gdg~e~~e~~~ffiGsk~gGKttiilr~-ldrde~~kPtl--------- 71 (397) T PTHR13236 2 ALLPGAGEMPSETLWEIAKAEVEKRGINGSEGDGAEIAEKFVFFIGSKNGGKTTIILRC-LDRDEPPKPTL--------- 71 (397) T ss_pred CCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEEECCCCHHHHHHHH-HCCCCCCCCCE--------- T ss_conf 53200023676658999999998515675411353001016888873488546677656-32345678740--------- Q ss_pred CCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHHHHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHH Q ss_conf 44334202233100067745511016787178871123200110581012003343330000313689999999999999 Q Fun_An_XP_0013 88 ANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLLKPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRH 167 (523) Q Consensus 88 a~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LLk~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~ 167 (523) ||||+|----. ...-.--=+++|=| .|..+...|+-.-++..++..-.+|+|||+|+|......+..|+.-++. T Consensus 72 ----aLEYtygRr~~-g~~~~Kdiah~WEL-GGg~~~~~li~iPit~~~l~~~~~~lvLDlS~p~~~w~~~~~~~~~~~~ 145 (397) T PTHR13236 72 ----ALEYTYGRRAK-GHNTPKDIAHFWEL-GGGTSLLDLISIPITGDTLRTFSLVLVLDLSKPNDLWPTLENLLQATKS 145 (397) T ss_pred ----EEEECHHHHHC-CCCCCCCEEEEEEC-CCCCCHHHHHHHCCCCHHHHHEEEEEEEECCCCCHHHHHHHHHHHHHHH T ss_conf ----00000111104-68885303565531-7742457786412230125312011044057640024549999999999 Q ss_pred HHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC-----------CCCCCCCCCCCCCCCCCCCCEEEEEECCC Q ss_conf 9850695888999999999862268876777776777766-----------45321368887532678950799961875 Q Fun_An_XP_0013 168 VLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS-----------AGPVTIPLGPGEWDEGLGIPMCVVCQGAD 236 (523) Q Consensus 168 hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s-----------~~~v~lPLg~g~lt~nLGiPi~VVctkaD 236 (523) ++++.....-....+...+-|.+....-..+.....+.+. +....--...-.+.+.++||+++|-.|-| T Consensus 146 ~~~~~~~~~~~~~~~~~~~~r~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~p~~~~i~g~kyD 225 (397) T PTHR13236 146 HVDKVLLKLGKTNAKAVSEMRQRIWNNMPKDHPVSCCLGLLLESLVPFIVNDNITGNAFPDLELVDPFPIPLVIVGSKYD 225 (397) T ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHH T ss_conf 99999998520135678988888874200124689999999988888888877764320235655107811688520110 Q ss_pred HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHCCCCCCCCCCCCCC--CCCCCCEEEECC Q ss_conf 567888635885568999999999999871841255212332103456553225322466755112--311462457468 Q Fun_An_XP_0013 237 KIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIHSSLGIHSLLKRQSLKH--NVIDRDKILVPS 314 (523) Q Consensus 237 ~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh~~lgih~ll~~~~~~a--~vverDav~VPa 314 (523) .....+-|. -..+-+.||-+.-.|||+|+|+|.+...-. ..+... +..+.+..+... .+-...-++||+ T Consensus 226 ~f~~~~~e~------rk~~~~~Lr~~ah~~Ga~L~~~s~~~~~l~-~~~~~~--~~~l~Fg~~~~~~~~~~~~~P~~~~~ 296 (397) T PTHR13236 226 VFQDFDSEK------RKVICRTLRFLAHAYGASLLFLSSKSEALL-KKVRGV--INHLAFGSPLPKSILVDHNKPLAIPA 296 (397) T ss_pred HHCCCCHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-HHHHHH--HHHHHHHHHHHHHHHHCCCCCEEEEC T ss_conf 110544678------999999999999974368767742258999-999999--98886303566776520457716870 Q ss_pred CCCHHHHEEE Q ss_conf 9882141022 Q Fun_An_XP_0013 315 NWDSWGKIRI 324 (523) Q Consensus 315 GWDsw~KI~I 324 (523) |.|+|.+|+. T Consensus 297 g~d~~~~~g~ 306 (397) T PTHR13236 297 GLDSLAKIGL 306 (397) T ss_pred CCHHHHHCCC T ss_conf 6134766067 No 6 >KOG3929 Uncharacterized conserved protein [Function unknown] Probab=99.09 E-value=1.9e-10 Score=90.36 Aligned_columns=235 Identities=20% Q ss_pred CEEEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECC-CCCCCCEEEEEEECCCCHHH Q ss_conf 20478864779873212323311112455663122565674444334202233100067-74551101678717887112 Q Fun_An_XP_0013 46 EKNLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDAD-HEDTLARVSAYLLSEPSLSF 124 (523) Q Consensus 46 sKnilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D-~eD~~aR~svyiL~d~d~~~ 124 (523) +..|+++|-.+- ++++-.-= +|.+-+.+| -.+|||+|---.--. -.|. .|+|-| .|.... T Consensus 45 E~~I~~~Gn~~~--tt~I~~~F----------dR~e~~~~p---tlaLEYtygRR~~g~~~kdi---aN~WEL-Ggg~~~ 105 (363) T KOG3929 45 EFFIGSKGNGGK--TTIILRCF----------DRDEPPKPP---TLALEYTYGRRAKGHNPKDI---ANFWEL-GGGTSL 105 (363) T ss_pred HCEEEEECCCCE--EEEEEECC----------CCCCCCCCC---CEEEEEHHHHHHCCCCCHHH---HHHHHC-CCCCCH T ss_conf 205677338850--66533005----------765678997---21221012344147885145---655532-673246 Q ss_pred HHHHHHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCC Q ss_conf 32001105810120033433300003136899999999999999850695888999999999862268876777776777 Q Fun_An_XP_0013 125 APLLKPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGF 204 (523) Q Consensus 125 ~~LLk~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~ 204 (523) ..||---.+-.++.-..+|++||||+|--+--.+.+-..-+|.|++.+..-...+.-++....+.|...--..+.+ T Consensus 106 ~~LLsVPit~~~l~~~slIL~LDls~p~~~W~t~E~~~~~~R~~vd~~~~~~~k~~~~L~E~mrqR~~~rvgqd~~---- 181 (363) T KOG3929 106 LDLLSVPITGDTLRTFSLILVLDLSKPNDLWPTMENLLQATRSHVDKVIMKLGKTNAKLVEEMRQRIWNRVGQDHP---- 181 (363) T ss_pred HHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCC---- T ss_conf 8886055455628775666765115624432579999999998999999987414889999999999986214687---- Q ss_pred CCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHH Q ss_conf 76645321368887532678950799961875567888635885568999999999999871841255212332103456 Q Fun_An_XP_0013 205 TSSAGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSL 284 (523) Q Consensus 205 ~~s~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~L 284 (523) .-++-+++.+|++.|..|-|-..-.|-|+.- -+-|+||-..--|||+|.+-|.+-++-. .+ T Consensus 182 ------------d~e~~dP~P~PV~IVgsKYDvFq~FesekRk------H~C~~LRf~Ah~yGaaLlmfSskMe~l~-K~ 242 (363) T KOG3929 182 ------------DHELIDPFPVPVVIVGSKYDVFQDFESEKRK------HICKTLRFVAHYYGAALLMFSSKMEALL-KK 242 (363) T ss_pred ------------CCCCCCCCCCCEEEECCCCHHHCCCCHHHHH------HHHHHHHHHHHHHHHHHHHHHHHHHHHH-HH T ss_conf ------------4000277885347853520001266367899------9999999999997789999888789999-99 Q ss_pred HHHHCCCCCCCCCCCCC--CCCCCCCEEEECCCCCHHHHEEE Q ss_conf 55322532246675511--23114624574689882141022 Q Fun_An_XP_0013 285 IHSSLGIHSLLKRQSLK--HNVIDRDKILVPSNWDSWGKIRI 324 (523) Q Consensus 285 lh~~lgih~ll~~~~~~--a~vverDav~VPaGWDsw~KI~I 324 (523) +.-. |.-+-|..+.. +-|-----.||-+|.|||++|++ T Consensus 243 ir~~--i~HlaFG~~~~~s~~vD~NkPlfi~~G~DS~~~IG~ 282 (363) T KOG3929 243 IRGV--INHLAFGIDKSKSICVDQNKPLFITAGLDSFGQIGS 282 (363) T ss_pred HHHH--HHHHHCCCCCCCCEEEECCCCEEEEECCCCHHHCCC T ss_conf 8777--775404765766545307874589855532233378 No 7 >2fg5_A RAB-22B, RAS-related protein RAB-31; G-protein, GTP analogue, structural genomics, structural genomics consortium, SGC; HET: GNP; 2.80A {Homo sapiens} SCOP: c.37.1.8 Probab=98.29 E-value=0.00012 Score=52.61 Aligned_columns=175 Identities=18% Q ss_pred HHHHCCCCCEEEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEE Q ss_conf 66404884204788647798732123233111124556631225656744443342022331000677455110167871 Q Fun_An_XP_0013 38 VANGKRLPEKNLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLL 117 (523) Q Consensus 38 vss~~rlpsKnilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL 117 (523) |..+..+.+-.|+|+|....||+||+..+....-.. .+...- +..|....+...++. .++.+|-. T Consensus 15 ~~~~~~~k~~KI~iiG~~~vGKSsLi~~l~~~~~~~----~~~~T~--------~~~~~~~~~~~~~~~---~~~~i~d~ 79 (192) T 2fg5_A 15 VPRGSAIRELKVCLLGDTGVGKSSIVCRFVQDHFDH----NISPTI--------GASFMTKTVPCGNEL---HKFLIWDT 79 (192) T ss_dssp ------CEEEEEEEEECTTSSHHHHHHHHHHCCCCT----TCCCCS--------SEEEEEEEEECSSSE---EEEEEEEE T ss_pred CCCCCCCCEEEEEEEECCCCCHHHHHHHHHCCCCCC----CCCCCE--------EEEEEEEEECCCCEE---EEEECCCC T ss_conf 778777654789998069976899999987281067----767622--------334566641046501---11000001 Q ss_pred CCCCHHHHHHHHHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCC Q ss_conf 78871123200110581012003343330000313689999999999999985069588899999999986226887677 Q Fun_An_XP_0013 118 SEPSLSFAPLLKPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSS 197 (523) Q Consensus 118 ~d~d~~~~~LLk~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~ 197 (523) .+.-.+..+.+..+. .-..++++.|.+.+.++ +.+.+|+..+++... T Consensus 80 -~~~~~~~~~~~~~~~----~~~~~i~v~d~~~~~s~-~~i~~~~~~i~~~~~--------------------------- 126 (192) T 2fg5_A 80 -AGQERFHSLAPMYYR----GSAAAVIVYDITKQDSF-YTLKKWVKELKEHGP--------------------------- 126 (192) T ss_dssp -CCSGGGGGGTHHHHT----TCSEEEEEEETTCTHHH-HHHHHHHHHHHHHSC--------------------------- T ss_pred -CHHHHHHHHHHHHHH----HHHHEEEEECCCCHHHH-HHHHHHHHHHHHHCC--------------------------- T ss_conf -002355678888763----11100122103440568-999999999987258--------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCC Q ss_conf 77767777664532136888753267895079996187556788863588556899999999999987184125521233 Q Fun_An_XP_0013 198 SGGAQGFTSSAGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFL 277 (523) Q Consensus 198 ~~~~~~~~~s~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~ 277 (523) ..+|++||++|+|....-+. +.+.++.+|-++++.+|.+|++. T Consensus 127 --------------------------~~~~iilVgnK~Dl~~~~~~-----------~~~~~~~~~k~~~~~~~evSak~ 169 (192) T 2fg5_A 127 --------------------------ENIVMAIAGNKCDLSDIREV-----------PLKDAKEYAESIGAIVVETSAKN 169 (192) T ss_dssp --------------------------TTCEEEEEEECGGGGGGCCS-----------CHHHHHHHHHTTTCEEEECBTTT T ss_pred --------------------------CCCEEEEEECCCCHHHHCCC-----------CHHHHHHHHHHCCCEEEEEECCC T ss_conf --------------------------97068885052200011045-----------47899999996398599985268 Q ss_pred CCCHHHHHHHHCCCCCCCCCCC Q ss_conf 2103456553225322466755 Q Fun_An_XP_0013 278 ANSLQSLIHSSLGIHSLLKRQS 299 (523) Q Consensus 278 ~~nl~~Llh~~lgih~ll~~~~ 299 (523) ..+.+.|.... +..|.+-.| T Consensus 170 g~gV~elf~~i--~~~i~~~~p 189 (192) T 2fg5_A 170 AINIEELFQGI--SRQIPPLDP 189 (192) T ss_dssp TBSHHHHHHHH--HHTCC---- T ss_pred CCCHHHHHHHH--HHHCCCCCC T ss_conf 97888999999--986467887 No 8 >1x3s_A RAS-related protein RAB-18; GTPase, GNP, structural genomics, NPPSFA, national project on protein structural and functional analyses; HET: GNP; 1.32A {Homo sapiens} SCOP: c.37.1.8 Probab=98.24 E-value=3.6e-05 Score=56.04 Aligned_columns=173 Identities=17% Q ss_pred CCCEEEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHH Q ss_conf 84204788647798732123233111124556631225656744443342022331000677455110167871788711 Q Fun_An_XP_0013 44 LPEKNLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLS 123 (523) Q Consensus 44 lpsKnilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~ 123 (523) +|+-.|+|+|....||++|+..+.+..... .....- +..+.+..+.-.+.. .++.+|-. .+... T Consensus 13 ~~~~KI~viG~~~vGKTsLi~~~~~~~~~~----~~~~~~--------~~~~~~~~~~~~~~~---~~~~i~D~-~~~~~ 76 (195) T 1x3s_A 13 LTTLKILIIGESGVGKSSLLLRFTDDTFDP----ELAATI--------GVDFKVKTISVDGNK---AKLAIWDT-AGQER 76 (195) T ss_dssp EEEEEEEEECSTTSSHHHHHHHHHHSCCCT----TCCCCC--------SEEEEEEEEEETTEE---EEEEEEEE-CSSGG T ss_pred CCEEEEEEEECCCCCHHHHHHHHHCCCCCC----CCCCEE--------EEEEEEEEEEECCEE---EEEEEECC-CCHHH T ss_conf 451568998069987999999986581365----533202--------211257888887878---89885003-22002 Q ss_pred HHHHHHHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCC Q ss_conf 23200110581012003343330000313689999999999999985069588899999999986226887677777677 Q Fun_An_XP_0013 124 FAPLLKPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQG 203 (523) Q Consensus 124 ~~~LLk~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~ 203 (523) +..+.+..+..-.+ ++|+.|.+.+.++-. +.+|+..++.+.... T Consensus 77 ~~~~~~~~~~~~~~----~i~v~d~~~~~S~~~-~~~~~~~i~~~~~~~------------------------------- 120 (195) T 1x3s_A 77 FRTLTPSYYRGAQG----VILVYDVTRRDTFVK-LDNWLNELETYCTRN------------------------------- 120 (195) T ss_dssp GCCSHHHHHTTCCE----EEEEEETTCHHHHHT-HHHHHHHHTTCCSCS------------------------------- T ss_pred HHHHHHHHHCCCCC----EEEEEECCCCCCHHH-HHHHHHHHHHHCCCC------------------------------- T ss_conf 23343777225881----289972367410112-478887665410124------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHH Q ss_conf 77664532136888753267895079996187556788863588556899999999999987184125521233210345 Q Fun_An_XP_0013 204 FTSSAGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQS 283 (523) Q Consensus 204 ~~~s~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~ 283 (523) ++|++||++|+| |++..-..++ ++.|+-++|+.++.+|++...+.+. T Consensus 121 ---------------------~~piiiv~nK~D----l~~~~v~~~~--------~~~~~~~~~~~~~e~Sa~~~~gi~~ 167 (195) T 1x3s_A 121 ---------------------DIVNMLVGNKID----KENREVDRNE--------GLKFARKHSMLFIEASAKTCDGVQC 167 (195) T ss_dssp ---------------------CCEEEEEEECTT----SSSCCSCHHH--------HHHHHHHTTCEEEECCTTTCTTHHH T ss_pred ---------------------CCEEEEECCCCC----HHHCCCHHHH--------HHHHHHHCCCEEEEEECCCCCCHHH T ss_conf ---------------------530677426520----0110101789--------9999996298799985167878889 Q ss_pred HHHHHCCCCCCCCCCCCCCC Q ss_conf 65532253224667551123 Q Fun_An_XP_0013 284 LIHSSLGIHSLLKRQSLKHN 303 (523) Q Consensus 284 Llh~~lgih~ll~~~~~~a~ 303 (523) +.... +..++++..+... T Consensus 168 ~f~~i--~~~i~~~~~~~~~ 185 (195) T 1x3s_A 168 AFEEL--VEKIIQTPGLWES 185 (195) T ss_dssp HHHHH--HHHHHTSGGGTCC T ss_pred HHHHH--HHHHHHCCCCCCC T ss_conf 99999--9999744576764 No 9 >d1r2qa_ c.37.1.8 (A:) Rab5a {Human (Homo sapiens)} Probab=98.18 E-value=0.00048 Score=48.73 Aligned_columns=162 Identities=14% Q ss_pred HCCCCCEEEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCC Q ss_conf 04884204788647798732123233111124556631225656744443342022331000677455110167871788 Q Fun_An_XP_0013 41 GKRLPEKNLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEP 120 (523) Q Consensus 41 ~~rlpsKnilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~ 120 (523) ++++..-.|+|+|..+.||+||+..+....... .....- ...|.+..|...+.. .++.+|-. .+ T Consensus 1 ~~~~~~~ki~liG~~~vGKSsli~~~~~~~~~~----~~~~t~--------~~~~~~~~~~~~~~~---~~~~i~d~-~g 64 (170) T d1r2qa_ 1 GNKICQFKLVLLGESAVGKSSLVLRFVKGQFHE----FQESTI--------GAAFLTQTVCLDDTT---VKFEIWDT-AG 64 (170) T ss_dssp CCEEEEEEEEEECSTTSSHHHHHHHHHHSCCCT----TCCCCS--------SEEEEEEEEEETTEE---EEEEEEEE-CC T ss_pred CCCCEEEEEEEEECCCCCHHHHHHHHHCCCCCC----CCCCCE--------EEEEEEEEEEECCEE---EEEEEECC-CC T ss_conf 986114789998179987999999986480156----624420--------245434545557917---99987306-77 Q ss_pred CHHHHHHHHHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCC Q ss_conf 71123200110581012003343330000313689999999999999985069588899999999986226887677777 Q Fun_An_XP_0013 121 SLSFAPLLKPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGG 200 (523) Q Consensus 121 d~~~~~LLk~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~ 200 (523) ...+..+.+..+..- ..++++.|.+++.++ +.+++|+..++..... T Consensus 65 ~~~~~~~~~~~~~~~----~~~i~v~d~~~~~s~-~~~~~~~~~~~~~~~~----------------------------- 110 (170) T d1r2qa_ 65 QERYHSLAPMYYRGA----QAAIVVYDITNEESF-ARAKNWVKELQRQASP----------------------------- 110 (170) T ss_dssp SGGGGGGHHHHHTTC----SEEEEEEETTCHHHH-HHHHHHHHHHHHHSCT----------------------------- T ss_pred CCHHHHHHHHHHCCC----CEEEEEEECCCHHHH-HHHHHHHHHHHHHCCC----------------------------- T ss_conf 301123215540465----289999625301468-9999999998750378----------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCC Q ss_conf 67777664532136888753267895079996187556788863588556899999999999987184125521233210 Q Fun_An_XP_0013 201 AQGFTSSAGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANS 280 (523) Q Consensus 201 ~~~~~~s~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~n 280 (523) .+|+++|++|+| |..+..-..++ ++.++-.+++.+|.+|.+...+ T Consensus 111 ------------------------~~piilVgnK~D----l~~~~~v~~~~-------~~~~~~~~~~~~~e~Sa~~~~g 155 (170) T d1r2qa_ 111 ------------------------NIVIALSGNKAD----LANKRAVDFQE-------AQSYADDNSLLFMETSAKTSMN 155 (170) T ss_dssp ------------------------TCEEEEEEECGG----GGGGCCSCHHH-------HHHHHHHTTCEEEECCTTTCTT T ss_pred ------------------------CEEEEEEEEHHH----HHHHCCCCHHH-------HHHHHHHCCCEEEEEECCCCCC T ss_conf ------------------------557775320010----22104779899-------9999995598189986268978 Q ss_pred HHHHHHH Q ss_conf 3456553 Q Fun_An_XP_0013 281 LQSLIHS 287 (523) Q Consensus 281 l~~Llh~ 287 (523) ...|... T Consensus 156 i~elf~~ 162 (170) T d1r2qa_ 156 VNEIFMA 162 (170) T ss_dssp HHHHHHH T ss_pred HHHHHHH T ss_conf 8899999 No 10 >e1x3sa1 c.37.1.8 (A:2-178) Rab18 {Human (Homo sapiens) [TaxID:9606]} Probab=98.17 E-value=0.00011 Score=52.88 Aligned_columns=170 Identities=17% Q ss_pred CCCEEEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHH Q ss_conf 84204788647798732123233111124556631225656744443342022331000677455110167871788711 Q Fun_An_XP_0013 44 LPEKNLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLS 123 (523) Q Consensus 44 lpsKnilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~ 123 (523) +|+=.|+++|..+.||++|+.++.+..... .....- +..|....+...+.. -++.+|-. .+... T Consensus 5 ~~~iKi~ivG~~~vGKTtLi~~~~~~~~~~----~~~~t~--------~~~~~~~~~~~~~~~---~~~~l~d~-~~~~~ 68 (177) T e1x3sa1 5 LTTLKILIIGESGVGKSSLLLRFTDDTFDP----ELAATI--------GVDFKVKTISVDGNK---AKLAIWDT-AGQER 68 (177) T ss_pred CCEEEEEEECCCCCCHHHHHHHHHCCCCCC----CCCCCC--------EEEEEEEEEEECCEE---EEEEEECC-CCCHH T ss_conf 661358998079987999999986481167----514641--------013567899887948---99997116-53102 Q ss_pred HHHHHHHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCC Q ss_conf 23200110581012003343330000313689999999999999985069588899999999986226887677777677 Q Fun_An_XP_0013 124 FAPLLKPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQG 203 (523) Q Consensus 124 ~~~LLk~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~ 203 (523) +..+.+..+..- ..++++.|.+.+.++-. +.+|+.-++++.... T Consensus 69 ~~~~~~~~~~~~----d~~i~~~d~~~~~s~~~-~~~~~~~i~~~~~~~------------------------------- 112 (177) T e1x3sa1 69 FRTLTPSYYRGA----QGVILVYDVTRRDTFVK-LDNWLNELETYCTRN------------------------------- 112 (177) T ss_pred HHHHHHHHCCCC----CEEEEECCCCCCHHHHH-HHHHHHHHHHHCCCC------------------------------- T ss_conf 223304331576----06898504676101000-135899999745766------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHH Q ss_conf 77664532136888753267895079996187556788863588556899999999999987184125521233210345 Q Fun_An_XP_0013 204 FTSSAGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQS 283 (523) Q Consensus 204 ~~~s~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~ 283 (523) .+|++||++|+| +.+..-..+| ++.||.++|+..|.||++...+.+. T Consensus 113 ---------------------~~~iiiv~nK~D----l~~~~v~~~e--------~~~~~~~~~~~~~e~Sa~~g~gi~e 159 (177) T e1x3sa1 113 ---------------------DIVNMLVGNKID----KENREVDRNE--------GLKFARKHSMLFIEASAKTCDGVQC 159 (177) T ss_pred ---------------------CCCEEEECCCCH----HHCCCCCHHH--------HHHHHHHCCCEEEEEECCCCCCHHH T ss_conf ---------------------632245301100----1104678889--------9999996598299986168878789 Q ss_pred HHHHHCCCCCCCCCCCC Q ss_conf 65532253224667551 Q Fun_An_XP_0013 284 LIHSSLGIHSLLKRQSL 300 (523) Q Consensus 284 Llh~~lgih~ll~~~~~ 300 (523) +.... ++.+++.+++ T Consensus 160 ~f~~i--~~~i~~~~~~ 174 (177) T e1x3sa1 160 AFEEL--VEKIIQTPGL 174 (177) T ss_pred HHHHH--HHHHHCCCCC T ss_conf 99999--9998507775 No 11 >cd00154 Rab Rab family. Rab GTPases form the largest family within the Ras superfamily. There are at least 60 Rab genes in the human genome, and a number of Rab GTPases are conserved from yeast to humans. Rab GTPases are small, monomeric proteins that function as molecular switches to regulate vesicle trafficking pathways. The different Rab GTPases are localized to the cytosolic face of specific intracellular membranes, where they regulate distinct steps in membrane traffic pathways. In the GTP-bound form, Rab GTPases recruit specific sets of effector proteins onto membranes. Through their effectors, Rab GTPases regulate vesicle formation, actin- and tubulin-dependent vesicle movement, and membrane fusion. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide di Probab=98.17 E-value=0.00025 Score=50.58 Aligned_columns=151 Identities=15% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|..+.||++|+..+...+-.. +....- +..|....+.-.+.. .++.+|=. .|.-.+..+. T Consensus 3 i~ivG~~~vGKTsli~~~~~~~f~~----~~~~Ti--------~~~~~~k~i~~~~~~---~~~~i~Dt-~g~e~~~~~~ 66 (159) T cd00154 3 IVLIGDSGVGKTSLLLRFVDGKFDE----NYKSTI--------GVDFKSKTIEIDGKT---VKLQIWDT-AGQERFRSIT 66 (159) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCC----CCCCCC--------CEEEEEEEEEECCEE---EEEEEEEC-CCCHHHHHHH T ss_conf 8998269966899999986382474----446531--------003688899888959---99999865-9971456777 Q ss_pred HHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC Q ss_conf 11058101200334333000031368999999999999998506958889999999998622688767777767777664 Q Fun_An_XP_0013 129 KPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSSA 208 (523) Q Consensus 129 k~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s~ 208 (523) +..+.- --.++|+.|++++.++ +.+++|+..+++... T Consensus 67 ~~~~~~----~d~~iiv~d~~~~~Sf-~~i~~~~~~i~~~~~-------------------------------------- 103 (159) T cd00154 67 PSYYRG----AHGAILVYDITNRESF-ENLDKWLKELKEYAP-------------------------------------- 103 (159) T ss_pred HHHCCC----CCEEEEEEECCCHHHH-HHHHHHHHHHHHHCC-------------------------------------- T ss_conf 875148----9869999866997899-999999999998269-------------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHH Q ss_conf 5321368887532678950799961875567888635885568999999999999871841255212332103456 Q Fun_An_XP_0013 209 GPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSL 284 (523) Q Consensus 209 ~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~L 284 (523) -++|+++|++|+| |+.++.-..|+ .|.+|-++++..|.||.+...|.+.| T Consensus 104 ---------------~~~piiivgnK~D----l~~~~~v~~~~-------~~~~~~~~~~~~~e~Sa~~~~~i~~~ 153 (159) T cd00154 104 ---------------ENIPIILVGNKID----LEDQRQVSTEE-------AQQFAKENGLLFFETSAKTGENVEEL 153 (159) T ss_pred ---------------CCCEEEEEECCCC----HHHHCCCCHHH-------HHHHHHHCCCCEEEEEECCCCCHHHH T ss_conf ---------------9978999841310----00102656889-------99999965996999970479887899 No 12 >d3raba_ c.37.1.8 (A:) Rab3a {Rat (Rattus norvegicus)} SCOP: d1zbda_ Probab=98.15 E-value=0.00036 Score=49.52 Aligned_columns=162 Identities=14% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|..+.||+||+.++.+..... .....- +..|.+..+...+.. .++.+|-. .|...+..+. T Consensus 8 i~iiG~~~vGKTsLi~~~~~~~~~~----~~~~~~--------~~~~~~~~i~~~~~~---~~~~i~d~-~g~~~~~~~~ 71 (169) T d3raba_ 8 ILIIGNSSVGKTSFLFRYADDSFTP----AFVSTV--------GIDFKVKTIYRNDKR---IKLQIWDT-AGQERYRTIT 71 (169) T ss_dssp EEEECSTTSSHHHHHHHHHHSCCCS----SCCCCC--------SEEEEEEEEEETTEE---EEEEEEEE-CCSGGGHHHH T ss_pred EEEEECCCCCHHHHHHHHHCCCCCC----CCCCEE--------EEEEEEEEEEECCEE---EEEEEEEC-CCCCHHHHHH T ss_conf 9998369987999999986580154----402201--------103578999998868---99998515-7731122321 Q ss_pred HHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC Q ss_conf 11058101200334333000031368999999999999998506958889999999998622688767777767777664 Q Fun_An_XP_0013 129 KPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSSA 208 (523) Q Consensus 129 k~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s~ 208 (523) +..+..-. .++++.|.+.+.++ +.+++|+..++.....- T Consensus 72 ~~~~~~~d----~~i~v~d~~~~~s~-~~~~~~~~~i~~~~~~~------------------------------------ 110 (169) T d3raba_ 72 TAYYRGAM----GFILMYDITNEESF-NAVQDWSTQIKTYSWDN------------------------------------ 110 (169) T ss_dssp HTTTTTCC----EEEEEEETTCHHHH-HTHHHHHHHHHHHCCSC------------------------------------ T ss_pred HHHCCCCC----EEEEEEECCCCCHH-HHHHHHHHHHHHHHCCC------------------------------------ T ss_conf 21101345----78998622554205-66888999987653068------------------------------------ Q ss_pred CCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHH Q ss_conf 53213688875326789507999618755678886358855689999999999998718412552123321034565532 Q Fun_An_XP_0013 209 GPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIHSS 288 (523) Q Consensus 209 ~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh~~ 288 (523) +|++||++|+| |.++..-.++. ++.++-++|...|.||.+...+...+.... T Consensus 111 -----------------~pivvv~nK~D----l~~~~~v~~~~-------~~~~~~~~~~~~~~~Sa~~g~~i~e~f~~l 162 (169) T d3raba_ 111 -----------------AQVLLVGNKCD----MEDERVVSSER-------GRQLADHLGFEFFEASAKDNINVKQTFERL 162 (169) T ss_dssp -----------------CEEEEEEECTT----CGGGCCSCHHH-------HHHHHHHHTCEEEECBTTTTBSHHHHHHHH T ss_pred -----------------CCEEHHHHCCC----CCCCCCCCHHH-------HHHHHHHCCCEEEEEECCCCCCHHHHHHHH T ss_conf -----------------30000000123----21112578889-------999999559839998726898888999999 Q ss_pred CCCCCCCCC Q ss_conf 253224667 Q Fun_An_XP_0013 289 LGIHSLLKR 297 (523) Q Consensus 289 lgih~ll~~ 297 (523) +..+..| T Consensus 163 --i~~i~~~ 169 (169) T d3raba_ 163 --VDVICEK 169 (169) T ss_dssp --HHHHHTC T ss_pred --HHHHHHC T ss_conf --9999609 No 13 >2q3h_A RAS homolog gene family, member U; GTPase, structural genomics, structural genomics consortium, SGC; HET: GDP; 1.73A {Homo sapiens} Probab=98.15 E-value=4.8e-05 Score=55.22 Aligned_columns=167 Identities=11% Q ss_pred EEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHH Q ss_conf 47886477987321232331111245566312256567444433420223310006774551101678717887112320 Q Fun_An_XP_0013 48 NLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPL 127 (523) Q Consensus 48 nilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~L 127 (523) .|+|+|..+.||++|+..|.... ...... .....+..+.-.-.... -++.+|-. .+...+..+ T Consensus 22 KV~iiG~~gvGKTsLi~~l~~~~-------~~~~~~--------~t~~~~~~~~~~~~~~~-~~l~i~D~-~g~~~~~~~ 84 (201) T 2q3h_A 22 KCVLVGDGAVGKTSLVVSYTTNG-------YPTEYI--------PTAFDNFSAVVSVDGRP-VRLQLCDT-AGQDEFDKL 84 (201) T ss_dssp EEEEECSTTSSHHHHHHHHHC-----------------------CCSSEEEEEEEEETTEE-EEEEEEEC-CCSTTCSSS T ss_pred EEEEEECCCCCHHHHHHHHHCCC-------CCCCCC--------CEEEEEEEEEEEECCEE-EEEEECCC-CCCHHHCCC T ss_conf 89987079977899999987176-------565534--------22555789999860605-66530346-520011001 Q ss_pred HHHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 01105810120033433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 128 LKPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 128 Lk~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) .+..+.. -..++|+.|.+.+++|.+.+..|+..++.+.. T Consensus 85 ~~~~~~~----a~~~iiV~d~~~~~Sf~~~~~~~~~~i~~~~~------------------------------------- 123 (201) T 2q3h_A 85 RPLCYTN----TDIFLLCFSVVSPSSFQNVSEKWVPEIRCHCP------------------------------------- 123 (201) T ss_dssp GGGGGTT----CSEEEEEEETTCHHHHHHHHHTHHHHHHHHCS------------------------------------- T ss_pred CCCHHHH----HHHCCEEEECCCHHHHHHHHHHHHHHHHHHCC------------------------------------- T ss_conf 2001001----22122112113166677899987655543067------------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHH-HHHHHHHHHHHHHCCEEEE-ECCCCCCCHHHHH Q ss_conf 4532136888753267895079996187556788863588556899-9999999999871841255-2123321034565 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFD-FILQFMRTLLLKHGASLIY-TTPFLANSLQSLI 285 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fD-fIqQ~lRt~cLqYGAsLiY-TS~~~~~nl~~Ll 285 (523) .+|+++|++|+|..+.............. ...+..+.+|-++++-.++ ||.+...+.+.+. T Consensus 124 -----------------~~piiivgnK~D~~~~~~~~~~~~~~~~~~i~~~~~~~~~~~~~~~~~~e~Sak~~~gI~e~f 186 (201) T 2q3h_A 124 -----------------KAPIILVGTQSDLREDVKVLIELDKCKEKPVPEEAAKLLAEEIKAASYIECSALTQKNLKEVF 186 (201) T ss_dssp -----------------SSCEEEEEECGGGGGCHHHHHHHHTTTCCCCCHHHHHHHHHHHTCSEEEECCTTTCTTHHHHH T ss_pred -----------------CCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHH T ss_conf -----------------736888611478411356777765531255778999999997089538998515887878999 Q ss_pred HHHC Q ss_conf 5322 Q Fun_An_XP_0013 286 HSSL 289 (523) Q Consensus 286 h~~l 289 (523) .... T Consensus 187 ~~ii 190 (201) T 2q3h_A 187 DAAI 190 (201) T ss_dssp HHHH T ss_pred HHHH T ss_conf 9999 No 14 >2hxs_A RAB-26, RAS-related protein RAB-28; GTPase, signaling protein; HET: G3D; 1.10A {Homo sapiens} Probab=98.14 E-value=0.00056 Score=48.30 Aligned_columns=166 Identities=12% Q ss_pred HCCCCCEEEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCC Q ss_conf 04884204788647798732123233111124556631225656744443342022331000677455110167871788 Q Fun_An_XP_0013 41 GKRLPEKNLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEP 120 (523) Q Consensus 41 ~~rlpsKnilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~ 120 (523) ++.+-+=+|+++|..+.||++|+..+....... ++...- +.+|....|.-.+... -++.+|-. .+ T Consensus 1 ~~~~k~~ki~iiG~~~vGKSsli~~~~~~~~~~----~~~~T~--------~~~~~~~~v~~~~~~~--~~~~i~D~-~g 65 (178) T 2hxs_A 1 GSHMRQLKIVVLGDGASGKTSLTTCFAQETFGK----QYKQTI--------GLDFFLRRITLPGNLN--VTLQIWDI-GG 65 (178) T ss_dssp CCCCCEEEEEEECCTTSSHHHHHHHHHGGGTTH----HHHHTT--------TSSEEEEEEEETTTEE--EEEEEEEC-TT T ss_pred CCCCCEEEEEEEECCCCCHHHHHHHHHCCCCCC----CCCCEE--------EEEEEEEEECCCCCEE--EEEEEEEC-CC T ss_conf 986514789998079988999999986283377----622225--------5423545322320103--56777531-47 Q ss_pred CHHHHHHHHHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCC Q ss_conf 71123200110581012003343330000313689999999999999985069588899999999986226887677777 Q Fun_An_XP_0013 121 SLSFAPLLKPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGG 200 (523) Q Consensus 121 d~~~~~LLk~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~ 200 (523) ...+..+.+..+.. -..++++.|.+.|.++-. ++.|+..++.+....... T Consensus 66 ~~~~~~~~~~~~~~----~~~~i~v~d~~~~~s~~~-~~~~~~~i~~~~~~~~~~------------------------- 115 (178) T 2hxs_A 66 QTIGGKMLDKYIYG----AQGVLLVYDITNYQSFEN-LEDWYTVVKKVSEESETQ------------------------- 115 (178) T ss_dssp CCTTCTTHHHHHTT----CSEEEEEEETTCHHHHHT-HHHHHHHHHHHHHHHTCC------------------------- T ss_pred CCCCCCCCCCCCCC----CCCCEEEEECCCCCCCCC-HHHHHHHHHHHHCCCCCC------------------------- T ss_conf 43122112111210----000001322024554110-124567775310024656------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCC Q ss_conf 67777664532136888753267895079996187556788863588556899999999999987184125521233210 Q Fun_An_XP_0013 201 AQGFTSSAGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANS 280 (523) Q Consensus 201 ~~~~~~s~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~n 280 (523) +|+++|++|+| |+.++....++ ++.||-+||+..|.+|++...+ T Consensus 116 -------------------------~~iilV~nK~D----l~~~~~v~~~~-------~~~~~~~~~~~~~~~Sa~~~~~ 159 (178) T 2hxs_A 116 -------------------------PLVALVGNKID----LEHMRTIKPEK-------HLRFCQENGFSSHFVSAKTGDS 159 (178) T ss_dssp -------------------------CEEEEEEECGG----GGGGCSSCHHH-------HHHHHHHHTCEEEEECTTTCTT T ss_pred -------------------------CEEEEEECCCC----CHHHHCCCHHH-------HHHHHHHCCCEEEEEECCCCCC T ss_conf -------------------------30233302344----10222024588-------9999996499089996157878 Q ss_pred HHHHHHH Q ss_conf 3456553 Q Fun_An_XP_0013 281 LQSLIHS 287 (523) Q Consensus 281 l~~Llh~ 287 (523) ...+... T Consensus 160 I~e~f~~ 166 (178) T 2hxs_A 160 VFLCFQK 166 (178) T ss_dssp HHHHHHH T ss_pred HHHHHHH T ss_conf 8899999 No 15 >e1xtqa1 c.37.1.8 (A:3-169) GTP-binding protein RheB {Human (Homo sapiens) [TaxID:9606]} SCOP: u1xtsa_ u1xtra_ Probab=98.13 E-value=0.00012 Score=52.53 Aligned_columns=159 Identities=8% Q ss_pred CCEEEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHH Q ss_conf 42047886477987321232331111245566312256567444433420223310006774551101678717887112 Q Fun_An_XP_0013 45 PEKNLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSF 124 (523) Q Consensus 45 psKnilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~ 124 (523) .++-|+++|..+.||++|+..+....... +..... +..|...-..|.. ..++.+|-.+..+.. T Consensus 3 k~~Ki~ivG~~~vGKTsLi~~~~~~~~~~----~~~~t~--------~~~~~~~~~~~~~----~~~l~~~d~~g~~~~- 65 (167) T e1xtqa1 3 KSRKIAILGYRSVGKSSLTIQFVEGQFVD----SYDPTI--------ENTFTKLITVNGQ----EYHLQLVDTAGQDEY- 65 (167) T ss_pred CCEEEEEEECCCCCHHHHHHHHHCCCCCC----CCCCEE--------EEEEEEEEEECCE----EEEEEEEEECCCCCC- T ss_conf 74178998169987999999986381167----734405--------5310799998248----999999850362334- Q ss_pred HHHHHHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCC Q ss_conf 3200110581012003-343330000313689999999999999985069588899999999986226887677777677 Q Fun_An_XP_0013 125 APLLKPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQG 203 (523) Q Consensus 125 ~~LLk~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~ 203 (523) ..+....++++ .++++.|.+.|.+| +.+++|+.-+.++..+.+ T Consensus 66 -----~~~~~~~~~~~d~~ilv~d~~~~~sf-~~~~~~~~~i~~~~~~~~------------------------------ 109 (167) T e1xtqa1 66 -----SIFPQTYSIDINGYILVYSVTSIKSF-EVIKVIHGKLLDMVGKVQ------------------------------ 109 (167) T ss_pred -----CCCCCCCCCCCEEEEEEEEECCCCCH-HHHHHHHHHHHHHHCCCC------------------------------ T ss_conf -----34551114540279998641232102-356777789986412578------------------------------ Q ss_pred CCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHH Q ss_conf 77664532136888753267895079996187556788863588556899999999999987184125521233210345 Q Fun_An_XP_0013 204 FTSSAGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQS 283 (523) Q Consensus 204 ~~~s~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~ 283 (523) +|+++|++|+|. .++-..-.+-++.|+-++|+..|.||.+...+... T Consensus 110 ----------------------~piiivgnK~Dl-----------~~~~~v~~~~~~~~~~~~~~~~~e~Sak~~~~v~e 156 (167) T e1xtqa1 110 ----------------------IPIMLVGNKKDL-----------HMERVISYEEGKALAESWNAAFLESSAKENQTAVD 156 (167) T ss_pred ----------------------CCEEEEEECCCC-----------CCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCHHH T ss_conf ----------------------618998613464-----------22246898999999995598299997158977789 Q ss_pred HHHHHC Q ss_conf 655322 Q Fun_An_XP_0013 284 LIHSSL 289 (523) Q Consensus 284 Llh~~l 289 (523) +....+ T Consensus 157 ~f~~li 162 (167) T e1xtqa1 157 VFRRII 162 (167) T ss_pred HHHHHH T ss_conf 999999 No 16 >e1z2aa_ c.37.1.8 (A:) Rab23 {Mouse (Mus musculus) [TaxID:10090]} Probab=98.13 E-value=0.00012 Score=52.61 Aligned_columns=151 Identities=17% Q ss_pred EEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHH Q ss_conf 47886477987321232331111245566312256567444433420223310006774551101678717887112320 Q Fun_An_XP_0013 48 NLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPL 127 (523) Q Consensus 48 nilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~L 127 (523) .|+++|..+.||+||+..+.+..... .....- +..|.+..+.-.+.+ .++.+|-. .+...+..+ T Consensus 4 kI~ivG~~~vGKSsli~~l~~~~~~~----~~~~t~--------~~~~~~~~~~~~~~~---~~l~i~d~-~~~~~~~~~ 67 (164) T e1z2aa_ 4 KMVVVGNGAVGKSSMIQRYCKGIFTK----DYKKTI--------GVDFLERQIQVNDED---VRLMLWDT-AGQEEFDAI 67 (164) T ss_pred EEEEECCCCCCHHHHHHHHHCCCCCC----CCCCEE--------EEEEEEEEEEECCEE---EEEEECCC-CCCCHHHHH T ss_conf 89998289988999999986480167----623404--------533588999973288---87410146-422024577 Q ss_pred HHHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 01105810120033433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 128 LKPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 128 Lk~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) .+..+..-. .++++.|.+++.++ +.+.+|+.-++.+..+ T Consensus 68 ~~~~~~~~d----~~i~v~d~~~~~s~-~~~~~~~~~i~~~~~~------------------------------------ 106 (164) T e1z2aa_ 68 TKAYYRGAQ----ACVLVFSTTDRESF-EAISSWREKVVAEVGD------------------------------------ 106 (164) T ss_pred HHHHCCCCC----EEEEEEECCCCCCH-HHHHHHHHHHHHHCCC------------------------------------ T ss_conf 886405875----79999740455424-6788888874310023------------------------------------ Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHH Q ss_conf 45321368887532678950799961875567888635885568999999999999871841255212332103456 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSL 284 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~L 284 (523) +|++||++|+| +..+.....+ .++.++-++|+..|.||.+...+...+ T Consensus 107 ------------------~piiiv~nK~D----l~~~~~i~~~-------~~~~~~~~~~~~~~e~Sa~~~~~i~~~ 154 (164) T e1z2aa_ 107 ------------------IPTALVQNKID----LLDDSCIKNE-------EAEGLAKRLKLRFYRTSVKEDLNVSEV 154 (164) T ss_pred ------------------CEEEEEEECCC----CCCCCCCCHH-------HHHHHHHHCCCEEEEEECCCCCCHHHH T ss_conf ------------------00234442002----1112367989-------999999965990999971589888899 No 17 >e2erxa1 c.37.1.8 (A:6-176) di-Ras2 {Human (Homo sapiens) [TaxID:9606]} SCOP: u2erxb_ u2gf0c_ u2gf0d_ u2gf0a1 u2gf0b_ Probab=98.11 E-value=0.00026 Score=50.42 Aligned_columns=158 Identities=16% Q ss_pred EEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHH Q ss_conf 47886477987321232331111245566312256567444433420223310006774551101678717887112320 Q Fun_An_XP_0013 48 NLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPL 127 (523) Q Consensus 48 nilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~L 127 (523) .|+|+|..+.||+|||..+.+..... .... .++-.|.-+..-+... -++.+|-. .|...+..+ T Consensus 4 kI~vvG~~~vGKTsli~~~~~~~~~~----~~~~----------t~~~~~~~~~~~~~~~--~~~~i~d~-~g~~~~~~~ 66 (171) T e2erxa1 4 RVAVFGAGGVGKSSLVLRFVKGTFRE----SYIP----------TVEDTYRQVISCDKSI--CTLQITDT-TGSHQFPAM 66 (171) T ss_pred EEEEEECCCCCHHHHHHHHHCCCCCC----CCCC----------EEEEEEEEEEEECCEE--EEEEEEEC-CCCHHHHHH T ss_conf 89998079987999999986382166----6243----------0220025799874647--89999730-561023343 Q ss_pred HHHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 01105810120033433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 128 LKPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 128 Lk~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) .+-.+..- ..++++.|.++++++ +.+..|...+++.-.... T Consensus 67 ~~~~~~~~----~~~i~v~d~~~~~s~-~~~~~~~~~l~~~~~~~~---------------------------------- 107 (171) T e2erxa1 67 QRLSISKG----HAFILVYSITSRQSL-EELKPIYEQICEIKGDVE---------------------------------- 107 (171) T ss_pred HHHHCCCC----CEEEEEECCCCCCCH-HHHHHHHHHHHHHHCCCC---------------------------------- T ss_conf 02211587----269999717742007-899999754666402678---------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHH Q ss_conf 45321368887532678950799961875567888635885568999999999999871841255212332103456553 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIHS 287 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh~ 287 (523) ++|++||++|+| |..+.....++. +.||-++|+.+|.+|++...++..+... T Consensus 108 -----------------~~piiivgnK~D----l~~~~~i~~~~~-------~~~~~~~~~~~~~~Sak~g~gi~e~f~~ 159 (171) T e2erxa1 108 -----------------SIPIMLVGNKCD----ESPSREVQSSEA-------EALARTWKCAFMETSAKLNHNVKELFQE 159 (171) T ss_pred -----------------CCCEEEEEECCC----CCCCCCCCHHHH-------HHHHHHCCCCEEEEECCCCCCHHHHHHH T ss_conf -----------------852799973135----663335447899-------9999964992899970589687899999 Q ss_pred HC Q ss_conf 22 Q Fun_An_XP_0013 288 SL 289 (523) Q Consensus 288 ~l 289 (523) .+ T Consensus 160 i~ 161 (171) T e2erxa1 160 LL 161 (171) T ss_pred HH T ss_conf 99 No 18 >d1wmsa_ c.37.1.8 (A:) Rab9a {Human (Homo sapiens)} Probab=98.11 E-value=0.00086 Score=47.08 Aligned_columns=158 Identities=13% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+|+|..+.||++|+..+....-.. +....- +..|....+..++.. -++.+|-.+...-+..... T Consensus 9 ivivG~~~vGKTsLi~~~~~~~~~~----~~~~t~--------~~~~~~~~i~~~~~~---i~l~~~d~~~~~~~~~~~~ 73 (174) T d1wmsa_ 9 VILLGDGGVGKSSLMNRYVTNKFDT----QLFHTI--------GVEFLNKDLEVDGHF---VTMQIWDTAGQERFRSLRT 73 (174) T ss_dssp EEEECCTTSSHHHHHHHHHHSCCCC--------CC--------SEEEEEEEEEETTEE---EEEEEEECCCCGGGHHHHG T ss_pred EEEEECCCCCHHHHHHHHHCCCCCC----CCCCEE--------EECEEEEEEEECCEE---EEEEEEECCCCCHHHHHHH T ss_conf 9998179987899999986381356----533315--------511056799998979---9999831247300102110 Q ss_pred HHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC Q ss_conf 11058101200334333000031368999999999999998506958889999999998622688767777767777664 Q Fun_An_XP_0013 129 KPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSSA 208 (523) Q Consensus 129 k~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s~ 208 (523) .+.-.+. .+|++.|.+.|+++ +.+..|..-++......... T Consensus 74 ~~~~~~d-----~~i~v~d~~~~~s~-~~i~~~~~~i~~~~~~~~~~--------------------------------- 114 (174) T d1wmsa_ 74 PFYRGSD-----CCLLTFSVDDSQSF-QNLSNWKKEFIYYADVKEPE--------------------------------- 114 (174) T ss_dssp GGGTTCS-----EEEEEEETTCHHHH-HTHHHHHHHHHHHHTCSCTT--------------------------------- T ss_pred EECCCCE-----EEEEEEECCCHHHH-HHHHHHHHHHHHHHCCCCCC--------------------------------- T ss_conf 0126865-----89998635886789-99989999999871003678--------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHC-CEEEEECCCCCCCHHHHHHH Q ss_conf 53213688875326789507999618755678886358855689999999999998718-41255212332103456553 Q Fun_An_XP_0013 209 GPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHG-ASLIYTTPFLANSLQSLIHS 287 (523) Q Consensus 209 ~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYG-AsLiYTS~~~~~nl~~Llh~ 287 (523) ++|+++|++|+|. ++.....|+ ++.++-++| ...|.||.+...|.+.+... T Consensus 115 ----------------~~piiivgnK~Dl-----~~~~v~~ee-------~~~~~~~~~~~~~~e~Sak~~~~I~e~f~~ 166 (174) T d1wmsa_ 115 ----------------SFPFVILGNKIDI-----SERQVSTEE-------AQAWCRDNGDYPYFETSAKDATNVAAAFEE 166 (174) T ss_dssp ----------------TSCEEEEEECTTC-----SSCSSCHHH-------HHHHHHHTTCCCEEECCTTTCTTHHHHHHH T ss_pred ----------------CCCEEEEECCCCC-----CCCCCCHHH-------HHHHHHHCCCCCEEEEECCCCCCHHHHHHH T ss_conf ----------------8528999514575-----435569899-------999999707982799860589888899999 Q ss_pred H Q ss_conf 2 Q Fun_An_XP_0013 288 S 288 (523) Q Consensus 288 ~ 288 (523) . T Consensus 167 l 167 (174) T d1wmsa_ 167 A 167 (174) T ss_dssp H T ss_pred H T ss_conf 9 No 19 >d1g16a_ c.37.1.8 (A:) Rab-related protein Sec4 {Baker's yeast (Saccharomyces cerevisiae)} Probab=98.09 E-value=0.00049 Score=48.65 Aligned_columns=153 Identities=13% Q ss_pred EEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHH Q ss_conf 47886477987321232331111245566312256567444433420223310006774551101678717887112320 Q Fun_An_XP_0013 48 NLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPL 127 (523) Q Consensus 48 nilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~L 127 (523) .|+++|..+.||+||+..+...+... ....+- +..|.+..+...+.. .++.+|-. .+...+ T Consensus 4 Ki~ivG~~~vGKTsLi~~l~~~~~~~----~~~~~~--------~~~~~~~~~~~~~~~---~~~~i~d~-~g~~~~--- 64 (166) T d1g16a_ 4 KILLIGDSGVGKSCLLVRFVEDKFNP----SFITTI--------GIDFKIKTVDINGKK---VKLQIWDT-AGQERF--- 64 (166) T ss_dssp EEEEEESTTSSHHHHHHHHHHCCCCC-------------------CCEEEEEEESSSCE---EEEEEECC-TTGGGT--- T ss_pred EEEEEECCCCCHHHHHHHHHCCCCCC----CCCCCC--------CEEEEEEEEEECCCC---EEEEEEEC-CCCCCC--- T ss_conf 89998079987999999986480077----624454--------114688899875841---36887205-783200--- Q ss_pred HHHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC Q ss_conf 0110581012003-343330000313689999999999999985069588899999999986226887677777677776 Q Fun_An_XP_0013 128 LKPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTS 206 (523) Q Consensus 128 Lk~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~ 206 (523) ..+....++.+ .++++.|.++|.++ +.+++|++.++.. T Consensus 65 --~~~~~~~~~~~d~~i~v~d~~~~~s~-~~~~~~~~~i~~~-------------------------------------- 103 (166) T d1g16a_ 65 --RTITTAYYRGAMGIILVYDITDERTF-TNIKQWFKTVNEH-------------------------------------- 103 (166) T ss_dssp --SCCCHHHHTTEEEEEEEEETTCHHHH-HTHHHHHHHHHHH-------------------------------------- T ss_pred --CCHHHHHCCCCCEEEEEEECCCCCHH-HHHHHHHHHHHHC-------------------------------------- T ss_conf --00124332699689999851565338-8999999998612-------------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHH Q ss_conf 64532136888753267895079996187556788863588556899999999999987184125521233210345655 Q Fun_An_XP_0013 207 SAGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIH 286 (523) Q Consensus 207 s~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh 286 (523) ..-++|++||.+|+| |++..-..+| ++.|+-++|...|-+|.+...+...|.+ T Consensus 104 ---------------~~~~~piivv~nK~D----l~~~~v~~~e--------~~~~~~~~~~~~~e~Sa~~g~gv~~lf~ 156 (166) T d1g16a_ 104 ---------------ANDEAQLLLVGNKSD----METRVVTADQ--------GEALAKELGIPFIESSAKNDDNVNEIFF 156 (166) T ss_dssp ---------------SCTTCEEEEEEECTT----CTTCCSCHHH--------HHHHHHHHTCCEEECBTTTTBSHHHHHH T ss_pred ---------------CCCCCCEEEEEECHH----HHHCCCCHHH--------HHHHHHHCCCCEEEEECCCCCCHHHHHH T ss_conf ---------------689851666763102----2200675889--------9999996599399996158988889999 Q ss_pred H Q ss_conf 3 Q Fun_An_XP_0013 287 S 287 (523) Q Consensus 287 ~ 287 (523) . T Consensus 157 ~ 157 (166) T d1g16a_ 157 T 157 (166) T ss_dssp H T ss_pred H T ss_conf 9 No 20 >2j1l_A RHO-related GTP-binding protein RHOD; GTPase, membrane, prenylation, hydrolase, nucleotide-binding, methylation, lipoprotein, endosome dynamics; HET: GDP; 2.5A {Homo sapiens} Probab=98.07 E-value=4.2e-05 Score=55.62 Aligned_columns=183 Identities=12% Q ss_pred HHHHHHHHHHCCCCC-EE--EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCC Q ss_conf 898887664048842-04--788647798732123233111124556631225656744443342022331000677455 Q Fun_An_XP_0013 32 SSMLDSVANGKRLPE-KN--LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDT 108 (523) Q Consensus 32 ssiL~~vss~~rlps-Kn--ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~ 108 (523) +.++.+.+...+-|. +. |+++|..+.||+|||..+...........- ........+.-++.. T Consensus 17 ~~~~~~~~~~~~~~~~r~iKI~iiG~~gvGKSSLi~~l~~~~~~~~~~~t-------------~~~~~~~~~~~~~~~-- 81 (214) T 2j1l_A 17 NLYFQSMAGEEAPPGVRSVKVVLVGDGGCGKTSLLMVFADGAFPESYTPT-------------VFERYMVNLQVKGKP-- 81 (214) T ss_dssp ---------------CCEEEEEEEECTTSSHHHHHHHHHC-------CCC-------------CCEEEEEEEEETTEE-- T ss_pred CCHHHHCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHCCCCCCCCCCC-------------EEEEEEEEEEECCEE-- T ss_conf 21022213224777776378998707997799999998637336764650-------------135789998646847-- Q ss_pred CCEEEEEEECCCCHHHHHHHHHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH Q ss_conf 11016787178871123200110581012003343330000313689999999999999985069588899999999986 Q Fun_An_XP_0013 109 LARVSAYLLSEPSLSFAPLLKPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWR 188 (523) Q Consensus 109 ~aR~svyiL~d~d~~~~~LLk~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~ 188 (523) -++.+|-. .|...+..+-+..+..-. .+++|.|++.|+++-.-...|...++.... T Consensus 82 -~~~~iwD~-~g~~~~~~~~~~~~~~~~----~iilV~d~~~~~s~~~~~~~~~~~~~~~~~------------------ 137 (214) T 2j1l_A 82 -VHLHIWDT-AGQDDYDRLRPLFYPDAS----VLLLCFDVTSPNSFDNIFNRWYPEVNHFCK------------------ 137 (214) T ss_dssp -EEEEEEEC----------------CEE----EEEEEEETTCHHHHHHHHHTHHHHHHHHCS------------------ T ss_pred -EEEECCCC-CCHHHHHHHHHHHCCCCE----EEEEEECCCCHHHHHHHHHHHHHHHHHHCC------------------ T ss_conf -87410356-501121001022204404----566531133003344444678999986248------------------ Q ss_pred HCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHH-HHHHHHHHC Q ss_conf 2268876777776777766453213688875326789507999618755678886358855689999999-999998718 Q Fun_An_XP_0013 189 DRKRGMDSSSGGAQGFTSSAGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQF-MRTLLLKHG 267 (523) Q Consensus 189 e~~~~~~~~~~~~~~~~~s~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~-lRt~cLqYG 267 (523) .+|+++|++|||....-+....+.+.-..-|... .+.++-++| T Consensus 138 ------------------------------------~~piilvgnK~Dl~~~~~~~~~~~~~~~~~i~~~~~~~~a~~~~ 181 (214) T 2j1l_A 138 ------------------------------------KVPIIVVGCKTDLRKDKSLVNKLRRNGLEPVTYHRGQEMARSVG 181 (214) T ss_dssp ------------------------------------SCCEEEEEECGGGGSCHHHHHHHHHTTCCCCCHHHHHHHHHHTT T ss_pred ------------------------------------CCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCC T ss_conf ------------------------------------86354211356631124566677763047673789999999708 Q ss_pred CEEEE-ECCCCCCCHHHHHHHHC Q ss_conf 41255-21233210345655322 Q Fun_An_XP_0013 268 ASLIY-TTPFLANSLQSLIHSSL 289 (523) Q Consensus 268 AsLiY-TS~~~~~nl~~Llh~~l 289 (523) .--+| ||++...++..+..... T Consensus 182 ~~~~~E~Sakt~~gV~~~f~~ii 204 (214) T 2j1l_A 182 AVAYLECSARLHDNVHAVFQEAA 204 (214) T ss_dssp CSEEEECBTTTTBSHHHHHHHHH T ss_pred CCEEEEEECCCCCCHHHHHHHHH T ss_conf 93178874058867889999999 No 21 >d1d5ca_ c.37.1.8 (A:) Rab6 {Malaria parasite (Plasmodium falciparum)} Probab=98.07 E-value=0.0013 Score=45.95 Aligned_columns=154 Identities=11% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|..+.||++|+..+....... .....- +..|....+...+.. .++.+|-.+...-...... T Consensus 4 i~i~G~~~vGKSsLi~~l~~~~~~~----~~~~t~--------~~~~~~~~~~~~~~~---~~~~~~d~~g~~~~~~~~~ 68 (162) T d1d5ca_ 4 LVFLGEQAVGKTSIITRFMYDTFDN----NYQSTI--------GIDFLSKTLYLDEGP---VRLQLWDTAGQERFRSLIP 68 (162) T ss_dssp EEEECSTTSSHHHHHHHHHHSCCCT----TCCCCC--------CCEEEEEEEEETTEE---EEEEEEECCCSGGGGGGHH T ss_pred EEEEECCCCCHHHHHHHHHCCCCCC----CCCCEE--------EEEEEEEEEEECCEE---EEEEEECCCCCCHHHHHHH T ss_conf 8998179987999999986480156----613315--------546777897308816---9998623765203345667 Q ss_pred HHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC Q ss_conf 11058101200334333000031368999999999999998506958889999999998622688767777767777664 Q Fun_An_XP_0013 129 KPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSSA 208 (523) Q Consensus 129 k~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s~ 208 (523) .+.-.+. .++++.|.++++++ +.+.+|+.-++..... T Consensus 69 ~~~~~~d-----~~i~v~d~~~~~s~-~~~~~~l~~i~~~~~~------------------------------------- 105 (162) T d1d5ca_ 69 SYIRDSA-----AAIVVYDITNRQSF-ENTTKWIQDILNERGK------------------------------------- 105 (162) T ss_dssp HHHTTCS-----EEEEEEETTCHHHH-HTHHHHHHHHHHHHTT------------------------------------- T ss_pred HHHCCCC-----EEEEEEECCCCCCH-HHHHHHHHHHHHHCCC------------------------------------- T ss_conf 7632683-----89999744666777-8999999999751248------------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHH Q ss_conf 5321368887532678950799961875567888635885568999999999999871841255212332103456553 Q Fun_An_XP_0013 209 GPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIHS 287 (523) Q Consensus 209 ~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh~ 287 (523) .+|++||++|+| |+.++....+ .++.++-++|+..|.+|.+...+...|.-+ T Consensus 106 ----------------~~piilvgnK~D----l~~~~~v~~~-------~~~~~~~~~~~~~~~~Sa~~g~gv~~lf~~ 157 (162) T d1d5ca_ 106 ----------------DVIIALVGNKTD----LGDLRKVTYE-------EGMQKAQEYNTMFHETSAKAGHNIKVLFKK 157 (162) T ss_dssp ----------------SSEEEEEEECGG----GGGGCCSCHH-------HHHHHHHHTTCEEEECBTTTTBSCHHHHHH T ss_pred ----------------CEEEEEEEECCC----CCCCCCCCHH-------HHHHHHHHCCCEEEEEECCCCCCHHHHHHH T ss_conf ----------------657899752146----5322454889-------999999964992999972689687899999 No 22 >2p5s_A RAS and EF-hand domain containing; G-protein, RAB, GDP, structural genomics, SGC, structural genomics consortium; HET: GDP; 2.15A {Homo sapiens} Probab=98.06 E-value=0.00015 Score=52.04 Aligned_columns=170 Identities=19% Q ss_pred EEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHH Q ss_conf 47886477987321232331111245566312256567444433420223310006774551101678717887112320 Q Fun_An_XP_0013 48 NLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPL 127 (523) Q Consensus 48 nilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~L 127 (523) .|+|+|..+.||++|+..+.+............... .+..-..++....+.+|-. .+...+..+ T Consensus 30 KI~ivG~~~vGKSsLi~~l~~~~~~~~~~~t~~~~~---------------~~~~i~~~~~~~~l~i~d~-~~~~~~~~~ 93 (199) T 2p5s_A 30 KIVLAGDAAVGKSSFLMRLCKNEFRENISATLGVDF---------------QMKTLIVDGERTVLQLWDT-AGQERFRSI 93 (199) T ss_dssp EEEEESSTTSSHHHHHHHHHHCCCC----------C---------------EEEEEEETTEEEEEEEEEC-TTCTTCHHH T ss_pred EEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCEEEE---------------EEEEEEECCCEEEEEEECC-CCHHHHHHH T ss_conf 799980799879999999865812565145402467---------------8888741562145642025-412455678 Q ss_pred HHHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 01105810120033433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 128 LKPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 128 Lk~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) .+..+..- ..++++.|.++|.++ +.+.+|+..+++.... T Consensus 94 ~~~~~~~~----d~~ilv~d~~~~~s~-~~~~~~~~~i~~~~~~------------------------------------ 132 (199) T 2p5s_A 94 AKSYFRKA----DGVLLLYDVTCEKSF-LNIREWVDMIEDAAHE------------------------------------ 132 (199) T ss_dssp HHHHHHHC----SEEEEEEETTCHHHH-HTHHHHHHHHHHHC-------------------------------------- T ss_pred HHHHHHHH----CCEEEEEHHCCHHHH-HHHHCCCCCCCCCCCC------------------------------------ T ss_conf 89875330----022432001020233-3321000121113689------------------------------------ Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHH Q ss_conf 45321368887532678950799961875567888635885568999999999999871841255212332103456553 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIHS 287 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh~ 287 (523) ++|++||-+|+|..+....+... .+.+...+.++-++|+..|.+|.+...+++.++.. T Consensus 133 -----------------~~Piiiv~nK~Dl~~~~~~~~~~-----~i~~~~~~~~a~~~~~~~~~~Sak~g~gi~e~f~~ 190 (199) T 2p5s_A 133 -----------------TVPIMLVGNKADIRDTAATEGQK-----CVPGHFGEKLAMTYGALFCETSAKDGSNIVEAVLH 190 (199) T ss_dssp ------------------CCEEEEEECGGGHHHHHHTTCC-----CCCHHHHHHHHHHHTCEEEECCTTTCTTHHHHHHH T ss_pred -----------------CCEEEEEECCCCHHHHHHHHHHH-----CCCHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHH T ss_conf -----------------72798821125602344444431-----34688999999855986999852579888999999 Q ss_pred HCCCCCCCCCC Q ss_conf 22532246675 Q Fun_An_XP_0013 288 SLGIHSLLKRQ 298 (523) Q Consensus 288 ~lgih~ll~~~ 298 (523) . ++.+.+|+ T Consensus 191 i--~~~i~k~~ 199 (199) T 2p5s_A 191 L--AREVKKRT 199 (199) T ss_dssp H--HHHHTC-- T ss_pred H--HHHHHHCC T ss_conf 9--99997339 No 23 >e2gjsa1 c.37.1.8 (A:91-258) Rad {Human (Homo sapiens) [TaxID:9606]} SCOP: u2gjsb_ Probab=98.06 E-value=0.00014 Score=52.18 Aligned_columns=154 Identities=21% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+|+|..+.||++|+..+.+.. -+...|....+--....++ +..-++.+|-. .|...+ T Consensus 4 I~iiG~~~vGKTsli~~~~~~~----------~~~~~~~~~~~~~~~i~i~-------~~~~~l~i~D~-~G~~~~---- 61 (168) T e2gjsa1 4 VLLLGAPGVGKSALARIFGGVE----------DGPEAEAAGHTYDRSIVVD-------GEEASLMVYDI-WEQDGG---- 61 (168) T ss_pred EEEEECCCCCHHHHHHHHHCCC----------CCCCCCEEEEEEEEEEEEC-------CEEEEEEEEEE-EEECCC---- T ss_conf 9998079987999999883562----------6752350688899999971-------41579999975-310321---- Q ss_pred HHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 110581012003-3433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 129 KPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 129 k~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) ..+.+..++++ .++|+.|.+++.++ +.+++|...++.+...-+ T Consensus 62 -~~~~~~~~~~~d~~ilv~d~t~~~sf-~~~~~~~~~i~~~~~~~~---------------------------------- 105 (168) T e2gjsa1 62 -RWLPGHCMAMGDAYVIVYSVTDKGSF-EKASELRVQLRRARQTDD---------------------------------- 105 (168) T ss_pred -CCCCCCCCCCEEEEEEEEEECCCCCH-HHHHHHHHHHHHHHCCCC---------------------------------- T ss_conf -00020012452899998640235545-677578899996211267---------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHH Q ss_conf 45321368887532678950799961875567888635885568999999999999871841255212332103456553 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIHS 287 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh~ 287 (523) +|++||++|+|. .++-..-++.+|.++-+|++..+.||.+...+...|++. T Consensus 106 ------------------~piiivgnK~Dl-----------~~~~~v~~~e~~~~~~~~~~~~~e~Sak~~~~i~~~f~~ 156 (168) T e2gjsa1 106 ------------------VPIILVGNKSDL-----------VRSREVSVDEGRACAVVFDCKFIETSAALHHNVQALFEG 156 (168) T ss_pred ------------------CCEEEEEECCCC-----------CCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHH T ss_conf ------------------504567531332-----------324567989999999965980899970589788899999 Q ss_pred HC Q ss_conf 22 Q Fun_An_XP_0013 288 SL 289 (523) Q Consensus 288 ~l 289 (523) .+ T Consensus 157 i~ 158 (168) T e2gjsa1 157 VV 158 (168) T ss_pred HH T ss_conf 99 No 24 >1ek0_A GTP-binding protein YPT51; vesicular traffic, GTP hydrolysis, YPT/RAB protein, endocytosis, hydrolase; HET: MHO GNP GDP; 1.48A {Saccharomyces cerevisiae} SCOP: c.37.1.8 Probab=98.06 E-value=0.00057 Score=48.21 Aligned_columns=158 Identities=17% Q ss_pred EEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHH Q ss_conf 47886477987321232331111245566312256567444433420223310006774551101678717887112320 Q Fun_An_XP_0013 48 NLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPL 127 (523) Q Consensus 48 nilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~L 127 (523) .|+++|..+.||+||+..+....... .....- +..|.-..+...++. -++.+|-. .+...+..+ T Consensus 5 ki~ivG~~~vGKSsLi~~~~~~~~~~----~~~~t~--------~~~~~~~~~~~~~~~---~~l~i~d~-~g~~~~~~~ 68 (170) T 1ek0_A 5 KLVLLGEAAVGKSSIVLRFVSNDFAE----NKEPTI--------GAAFLTQRVTINEHT---VKFEIWDT-AGQERFASL 68 (170) T ss_dssp EEEEECSTTSSHHHHHHHHHHSCCCT----TCCCCS--------SEEEEEEEEEETTEE---EEEEEEEE-CCSGGGGGG T ss_pred EEEEECCCCCCHHHHHHHHHCCCCCC----CCCCCE--------EEEEEEEECCCCCCC---CCEEEECC-CCCHHHHHH T ss_conf 89988179977899999986483465----534310--------234554200012234---30243034-451123222 Q ss_pred HHHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 01105810120033433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 128 LKPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 128 Lk~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) .+..+..-.+ ++|+.|.++|.++ +++..|+..++....+.. T Consensus 69 ~~~~~~~~~~----~i~v~d~~~~~s~-~~~~~~~~~~~~~~~~~~---------------------------------- 109 (170) T 1ek0_A 69 APXYYRNAQA----ALVVYDVTKPQSF-IKARHWVKELHEQASKDI---------------------------------- 109 (170) T ss_dssp HHHHHTTCSE----EEEEEETTCHHHH-HHHHHHHHHHHHHSCTTC---------------------------------- T ss_pred HHHHCCCCCE----EEEEEECCCCCHH-HHHHHHHHHHHHHCCCCC---------------------------------- T ss_conf 0111256503----7899702365045-566788888864113564---------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHH Q ss_conf 45321368887532678950799961875567888635885568999999999999871841255212332103456553 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIHS 287 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh~ 287 (523) |++||++|+|....-.+..=-.++ ++.||-.+++..|.+|.+...++..|... T Consensus 110 -------------------~iivv~nK~D~~~~~~~~~v~~~~--------~~~~~~~~~~~~~e~Sa~~~~gi~elf~~ 162 (170) T 1ek0_A 110 -------------------IIALVGNKIDXLQEGGERKVAREE--------GEKLAEEKGLLFFETSAKTGENVNDVFLG 162 (170) T ss_dssp -------------------EEEEEEECGGGGGSSCCCCSCHHH--------HHHHHHHHTCEEEECCTTTCTTHHHHHHH T ss_pred -------------------CEEEEECCCCCCCHHHHHHHHHHH--------HHHHHHHCCCEEEEEECCCCCCHHHHHHH T ss_conf -------------------334541153100000001100789--------99999865983999862688688899999 No 25 >1x1r_A RAS-related protein M-RAS; GTP-binding; HET: GDP; 1.30A {Mus musculus} SCOP: c.37.1.8 Probab=98.05 E-value=0.00046 Score=48.81 Aligned_columns=166 Identities=20% Q ss_pred CCCEEEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHH Q ss_conf 84204788647798732123233111124556631225656744443342022331000677455110167871788711 Q Fun_An_XP_0013 44 LPEKNLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLS 123 (523) Q Consensus 44 lpsKnilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~ 123 (523) +|+=.|+|+|..+.||++|+..+.+..... +...-. +-.|...-..+.. ...+.+|-.+...-+ T Consensus 11 ~~~~Ki~iiG~~~vGKTsll~~l~~~~~~~----~~~~t~--------~~~~~~~~~~~~~----~~~~~i~d~~g~e~~ 74 (178) T 1x1r_A 11 LPTYKLVVVGDGGVGKSALTIQFFQKIFVP----DYDPTI--------EDSYLKHTEIDNQ----WAILDVLDTAGQEEF 74 (178) T ss_dssp CCEEEEEEECCTTSSHHHHHHHHHHSSCCT----TCCTTC--------CEEEEEEEEETTE----EEEEEEEECCSCGGG T ss_pred CCEEEEEEEECCCCCHHHHHHHHHCCCCCC----CCCCCE--------ECCCCCCCCCCCC----EEEEEEEEECCCCCC T ss_conf 866899988179977899999986282377----545411--------0011200123781----478877751365323 Q ss_pred HHHHHHHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCC Q ss_conf 23200110581012003-34333000031368999999999999998506958889999999998622688767777767 Q Fun_An_XP_0013 124 FAPLLKPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQ 202 (523) Q Consensus 124 ~~~LLk~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~ 202 (523) ..+.+.-++++ .++++.|++.+.++ +.+..|...+..+...- T Consensus 75 ------~~~~~~~~~~~~~~i~vfd~~~~~S~-~~~~~~~~~~~~~~~~~------------------------------ 117 (178) T 1x1r_A 75 ------SAMREQYMRTGDGFLIVYSVTDKASF-EHVDRFHQLILRVKDRE------------------------------ 117 (178) T ss_dssp ------CSSHHHHHHHCSEEEEEEETTCHHHH-HTHHHHHHHHHHHHTSS------------------------------ T ss_pred ------CCCCHHHCCCCCEEEEEEECCCCCCH-HHHHHHHHHHHHHCCCC------------------------------ T ss_conf ------32540010478547999742454211-24456666665302567------------------------------ Q ss_pred CCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCC-CH Q ss_conf 77766453213688875326789507999618755678886358855689999999999998718412552123321-03 Q Fun_An_XP_0013 203 GFTSSAGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLAN-SL 281 (523) Q Consensus 203 ~~~~s~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~-nl 281 (523) ++|+++|++|+| +..+..-..+. ++.||-+||...|.+|.+..+ |. T Consensus 118 ----------------------~~piiiVgnK~D----~~~~~~v~~~e-------~~~~~~~~~~~~~e~Sak~~~~~i 164 (178) T 1x1r_A 118 ----------------------SFPMILVANKVD----LMHLRKVTRDQ-------GKEMATKYNIPYIETSAKDPPLNV 164 (178) T ss_dssp ----------------------CCCEEEEEECTT----CSTTCCSCHHH-------HHHHHHHHTCCEEEEBCSSSCBSH T ss_pred ----------------------CCEEEEEEECCC----CCCCCCCCHHH-------HHHHHHHCCCCEEEEEECCCCCCH T ss_conf ----------------------640467752455----21003558899-------999999659948999615488787 Q ss_pred HHHHHHHCCCCCCCCC Q ss_conf 4565532253224667 Q Fun_An_XP_0013 282 QSLIHSSLGIHSLLKR 297 (523) Q Consensus 282 ~~Llh~~lgih~ll~~ 297 (523) +.+.+.. ++.++++ T Consensus 165 ~e~f~~i--~~~i~k~ 178 (178) T 1x1r_A 165 DKTFHDL--VRVIRQQ 178 (178) T ss_dssp HHHHHHH--HHHHHHC T ss_pred HHHHHHH--HHHHHHC T ss_conf 8999999--9999829 No 26 >1xtq_A GTP-binding protein RHEB; beta saddle, P-loop; HET: GDP; 2.00A {Homo sapiens} SCOP: c.37.1.8 Probab=98.01 E-value=0.0012 Score=46.09 Aligned_columns=159 Identities=11% Q ss_pred CEEEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHH Q ss_conf 20478864779873212323311112455663122565674444334202233100067745511016787178871123 Q Fun_An_XP_0013 46 EKNLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFA 125 (523) Q Consensus 46 sKnilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~ 125 (523) ++.|+++|..+.||++|+..+....... .....- +..|...-+.+.. ..++.+|-. .|...+. T Consensus 6 ~~Ki~iiG~~~vGKSsLi~~~~~~~~~~----~~~~t~--------~~~~~~~~~~~~~----~~~l~i~D~-~g~~~~~ 68 (177) T 1xtq_A 6 SRKIAILGYRSVGKSSLTIQFVEGQFVD----SYDPTI--------ENTFTKLITVNGQ----EYHLQLVDT-AGQDEYS 68 (177) T ss_dssp EEEEEEEESTTSSHHHHHHHHHHSCCCS----CCCSSC--------CEEEEEEEEETTE----EEEEEEEEC-CCCCTTC T ss_pred CEEEEEEECCCCCHHHHHHHHHCCCCCC----CCCCEE--------EEEEEEEECCCCE----EEEEEEEEC-CCCCCCC T ss_conf 4058998079987899999986272366----643123--------2001121013544----566421001-1000112 Q ss_pred HHHHHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC Q ss_conf 20011058101200334333000031368999999999999998506958889999999998622688767777767777 Q Fun_An_XP_0013 126 PLLKPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFT 205 (523) Q Consensus 126 ~LLk~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~ 205 (523) .+.+..+ ..-..++|+.|.+.|.++ +.++.|+.-+.++..+. T Consensus 69 ~~~~~~~----~~~d~~i~v~d~~~~~s~-~~~~~~~~~i~~~~~~~--------------------------------- 110 (177) T 1xtq_A 69 IFPQTYS----IDINGYILVYSVTSIKSF-EVIKVIHGKLLDMVGKV--------------------------------- 110 (177) T ss_dssp CCCGGGT----SSCCEEEEEEETTCHHHH-HHHHHHHHHHHHHHCSS--------------------------------- T ss_pred CCCCCCC----HHHHHHHHHHCCCCCCCC-CHHCCHHHHHHHHCCCC--------------------------------- T ss_conf 2233210----003332110001112320-00010012211100357--------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHH Q ss_conf 66453213688875326789507999618755678886358855689999999999998718412552123321034565 Q Fun_An_XP_0013 206 SSAGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLI 285 (523) Q Consensus 206 ~s~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Ll 285 (523) .+|+++|++|+| |+.+.....+ .++.+|-++|..+|.||.+...++..+. T Consensus 111 -------------------~~piiivgnK~D----l~~~~~v~~~-------~~~~~~~~~~~~~~e~Sa~~g~gi~elf 160 (177) T 1xtq_A 111 -------------------QIPIMLVGNKKD----LHMERVISYE-------EGKALAESWNAAFLESSAKENQTAVDVF 160 (177) T ss_dssp -------------------CCCEEEEEECTT----CGGGCCSCHH-------HHHHHHHHHTCEEEECCTTCHHHHHHHH T ss_pred -------------------CCCEEEEEECCC----CHHHCCCCHH-------HHHHHHHHCCCEEEEEECCCCCCHHHHH T ss_conf -------------------862699961257----3000157888-------9999999649828998616897888999 Q ss_pred HHHC Q ss_conf 5322 Q Fun_An_XP_0013 286 HSSL 289 (523) Q Consensus 286 h~~l 289 (523) ...+ T Consensus 161 ~~ii 164 (177) T 1xtq_A 161 RRII 164 (177) T ss_dssp HHHH T ss_pred HHHH T ss_conf 9999 No 27 >e1z06a1 c.37.1.8 (A:32-196) Rab-33b {Mouse (Mus musculus) [TaxID:10090]} Probab=98.00 E-value=0.00044 Score=48.97 Aligned_columns=156 Identities=13% Q ss_pred EEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHH Q ss_conf 47886477987321232331111245566312256567444433420223310006774551101678717887112320 Q Fun_An_XP_0013 48 NLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPL 127 (523) Q Consensus 48 nilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~L 127 (523) .|+++|..+.||++|+..+.+..... .....- +..|....+.-.+.. .++.+|-..........+ T Consensus 4 KI~iiG~~~vGKTsli~~~~~~~~~~----~~~~t~--------~~~~~~~~~~~~~~~---~~~~i~d~~~~~~~~~~~ 68 (165) T e1z06a1 4 KIIVIGDSNVGKTCLTYRFCAGRFPD----RTEATI--------GVDFRERAVDIDGER---IKIQLWDTAGQERFRKSM 68 (165) T ss_pred EEEEEECCCCCHHHHHHHHHCCCCCC----CCCCCE--------ECCCEEEEEEECCCE---EEEEEEECCCCCCHHHHH T ss_conf 99998269987899999986382367----624310--------000102676418917---999985035753012343 Q ss_pred HHHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 01105810120033433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 128 LKPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 128 Lk~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) ++..+..- -.++|+.|.+.+.++-. +.+|...++..+..- T Consensus 69 ~~~~~~~~----~~~ilv~d~~~~~s~~~-i~~~~~~i~~~~~~~----------------------------------- 108 (165) T e1z06a1 69 VQHYYRNV----HAVVFVYDMTNMASFHS-LPAWIEECKQHLLAN----------------------------------- 108 (165) T ss_pred HHHHHCCC----CEEEEEEECCCCCCHHH-HHHHHHHHHHHHCCC----------------------------------- T ss_conf 14330143----36899875056565678-988999999860347----------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCC---CHHHH Q ss_conf 453213688875326789507999618755678886358855689999999999998718412552123321---03456 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLAN---SLQSL 284 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~---nl~~L 284 (523) ++|++||++|+|. .++-.+..+.++.||-+|++.++.+|.|-.. |.+.+ T Consensus 109 -----------------~~piiivgnK~Dl-----------~~~~~v~~~~~~~~~~~~~~~~~e~SAK~~~~~~nv~~~ 160 (165) T e1z06a1 109 -----------------DIPRILVGNKCDL-----------RSAIQVPTDLAQKFADTHSMPLFETSAKNPNDNDHVEAI 160 (165) T ss_pred -----------------CCCEEEEEECCCC-----------HHCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHH T ss_conf -----------------8838999715684-----------000467989999999965994999853778777477899 Q ss_pred HH Q ss_conf 55 Q Fun_An_XP_0013 285 IH 286 (523) Q Consensus 285 lh 286 (523) .+ T Consensus 161 f~ 162 (165) T e1z06a1 161 FM 162 (165) T ss_pred HH T ss_conf 98 No 28 >1wms_A RAB-9, RAB9, RAS-related protein RAB-9A; GTPase; HET: GDP; 1.25A {Homo sapiens} SCOP: c.37.1.8 Probab=98.00 E-value=0.0013 Score=45.94 Aligned_columns=166 Identities=13% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+|+|..+.||+||+..+.+.+... .....- +..|.+..+...++. -.+.+|-.+...-.....- T Consensus 10 i~iiG~~~vGKSSLi~~l~~~~~~~----~~~~t~--------~~~~~~~~~~~~~~~---~~~~i~D~~~~~~~~~~~~ 74 (177) T 1wms_A 10 VILLGDGGVGKSSLMNRYVTNKFDT----QLFHTI--------GVEFLNKDLEVDGHF---VTMQIWDTAGQERFRSLRT 74 (177) T ss_dssp EEEECCTTSSHHHHHHHHHHSCCCC--------CC--------SEEEEEEEEEETTEE---EEEEEEECCCCGGGHHHHG T ss_pred EEEEECCCCCHHHHHHHHHCCCCCC----CCCCCE--------EEEEEEEEEEECCCE---EEEECCCCHHHHHHHHCCH T ss_conf 9998179976899999986480267----635740--------112467753223861---2210144101123321010 Q ss_pred HHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC Q ss_conf 11058101200334333000031368999999999999998506958889999999998622688767777767777664 Q Fun_An_XP_0013 129 KPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSSA 208 (523) Q Consensus 129 k~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s~ 208 (523) .++..+. .++++.|.+.++++-. +..|+.-++.+....... T Consensus 75 ~~~~~~~-----~ii~v~d~~~~~s~~~-~~~~~~~i~~~~~~~~~~--------------------------------- 115 (177) T 1wms_A 75 PFYRGSD-----CCLLTFSVDDSQSFQN-LSNWKKEFIYYADVKEPE--------------------------------- 115 (177) T ss_dssp GGGTTCS-----EEEEEEETTCHHHHHT-HHHHHHHHHHHHTCSCTT--------------------------------- T ss_pred HHCCCCC-----CEEEECCCCCCCCCCH-HHHHHHHHHHHHHHCCCC--------------------------------- T ss_conf 1103654-----0566335663000101-334378899874201345--------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEE-ECCCCCCCHHHHHHH Q ss_conf 5321368887532678950799961875567888635885568999999999999871841255-212332103456553 Q Fun_An_XP_0013 209 GPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIY-TTPFLANSLQSLIHS 287 (523) Q Consensus 209 ~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiY-TS~~~~~nl~~Llh~ 287 (523) ++|++||++|+|. .+..-..++ ++.++-+++.-.++ ||.+...+...++.. T Consensus 116 ----------------~~piiiv~nK~Dl-----~~~~v~~~~-------~~~~~~~~~~~~~~e~Sa~~g~gv~e~f~~ 167 (177) T 1wms_A 116 ----------------SFPFVILGNKIDI-----SERQVSTEE-------AQAWCRDNGDYPYFETSAKDATNVAAAFEE 167 (177) T ss_dssp ----------------TSCEEEEEECTTC-----SSCSSCHHH-------HHHHHHHTTCCCEEECCTTTCTTHHHHHHH T ss_pred ----------------CCCEEEEECCCCC-----CHHCCCHHH-------HHHHHHHHCCCCEEEEECCCCCCHHHHHHH T ss_conf ----------------7737998135571-----000356789-------999999807971899851688788899999 Q ss_pred HCCCCCCCCCC Q ss_conf 22532246675 Q Fun_An_XP_0013 288 SLGIHSLLKRQ 298 (523) Q Consensus 288 ~lgih~ll~~~ 298 (523) . +..++... T Consensus 168 l--~~~i~~~~ 176 (177) T 1wms_A 168 A--VRRVLATE 176 (177) T ss_dssp H--HHHHHTC- T ss_pred H--HHHHHHHC T ss_conf 9--99998505 No 29 >2f9l_A RAB11B, member RAS oncogene family; RAB11B GTPase, vesicle transport; HET: GDP; 1.55A {Homo sapiens} SCOP: c.37.1.8 Probab=97.99 E-value=0.0012 Score=46.14 Aligned_columns=157 Identities=14% Q ss_pred EEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHH Q ss_conf 47886477987321232331111245566312256567444433420223310006774551101678717887112320 Q Fun_An_XP_0013 48 NLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPL 127 (523) Q Consensus 48 nilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~L 127 (523) .|+|+|....||++|+..+....... +..... +..+.+..+...+.. ..+.+|-. .+...+..+ T Consensus 7 Ki~ivG~~~vGKTsli~~~~~~~~~~----~~~~t~--------~~~~~~~~~~~~~~~---~~~~i~d~-~~~~~~~~~ 70 (199) T 2f9l_A 7 KVVLIGDSGVGKSNLLSRFTRNEFNL----ESKSTI--------GVEFATRSIQVDGKT---IKAQIWDT-AGQERYRRI 70 (199) T ss_dssp EEEEESSTTSSHHHHHHHHHHSCCCC-------CCC--------SCEEEEEEEEETTEE---EEEEEEEC-SSGGGTTCC T ss_pred EEEEEECCCCCHHHHHHHHHCCCCCC----CCCCCE--------EEEEEEEEEEEEEEE---EEEEEECC-CCCCHHHHH T ss_conf 88998269976899999986283367----645614--------544565554310035---65565245-321012356 Q ss_pred HHHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 01105810120033433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 128 LKPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 128 Lk~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) .+..... ...++|+.|.+.+.+ .+.+.+|...++... T Consensus 71 ~~~~~~~----~~~~i~v~d~~~~~s-~~~~~~~~~~~~~~~-------------------------------------- 107 (199) T 2f9l_A 71 TSAYYRG----AVGALLVYDIAKHLT-YENVERWLKELRDHA-------------------------------------- 107 (199) T ss_dssp CHHHHTT----CSEEEEEEETTCHHH-HHTHHHHHHHHHHHS-------------------------------------- T ss_pred HHHHHCC----CCEEEEEECCCCHHH-HHHHHHHHHHHHHHC-------------------------------------- T ss_conf 6765047----837999702678668-899998899999834-------------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHH Q ss_conf 45321368887532678950799961875567888635885568999999999999871841255212332103456553 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIHS 287 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh~ 287 (523) +-.+|+++|++|+| |..++...++ -++.+|-++++.+|.+|.+...+++.|... T Consensus 108 ---------------~~~~piilVgnK~D----l~~~~~~~~~-------e~~~~a~~~~~~~~e~Saktg~~v~elf~~ 161 (199) T 2f9l_A 108 ---------------DSNIVIMLVGNKSD----LRHLRAVPTD-------EARAFAEKNNLSFIETSALDSTNVEEAFKN 161 (199) T ss_dssp ---------------CTTCEEEEEEECTT----CGGGCCSCHH-------HHHHHHHHTTCEEEECCTTTCTTHHHHHHH T ss_pred ---------------CCCCEEEEEEECCC----CCCCCCCCHH-------HHHHHHHHCCCCEEEEEECCCCCHHHHHHH T ss_conf ---------------89977999961057----2200146077-------888999973897378872378788899999 Q ss_pred HC Q ss_conf 22 Q Fun_An_XP_0013 288 SL 289 (523) Q Consensus 288 ~l 289 (523) .+ T Consensus 162 l~ 163 (199) T 2f9l_A 162 IL 163 (199) T ss_dssp HH T ss_pred HH T ss_conf 99 No 30 >e1z08a1 c.37.1.8 (A:17-183) Rab21 {Human (Homo sapiens) [TaxID:9606]} SCOP: u1z08d_ u1yzta1 u1yzua_ Probab=97.97 E-value=0.00045 Score=48.91 Aligned_columns=151 Identities=15% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|..+.||++|+..+.+..... .....- +..+....+..+++. .++.+|-. .+...+.... T Consensus 6 i~ivG~~~vGKSsLi~~l~~~~~~~----~~~~~~--------~~~~~~~~~~~~~~~---~~l~i~d~-~g~~~~~~~~ 69 (167) T e1z08a1 6 VVLLGEGCVGKTSLVLRYCENKFND----KHITTL--------GASFLTKKLNIGGKR---VNLAIWDT-AGQERFHALG 69 (167) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCC----CCCCEE--------EEEEEEEEEEECCEE---EEEEEECC-CCCHHHHHHH T ss_conf 9998279987999999986580156----634403--------420244799888879---99998425-5713556776 Q ss_pred HHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC Q ss_conf 11058101200334333000031368999999999999998506958889999999998622688767777767777664 Q Fun_An_XP_0013 129 KPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSSA 208 (523) Q Consensus 129 k~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s~ 208 (523) +.....-. .++++.|.++++++ +.+.+|+..++....+ T Consensus 70 ~~~~~~~~----~~i~v~d~~~~~s~-~~i~~~~~~i~~~~~~------------------------------------- 107 (167) T e1z08a1 70 PIYYRDSN----GAILVYDITDEDSF-QKVKNWVKELRKMLGN------------------------------------- 107 (167) T ss_pred HHHHHCCC----CEEEEEECCCCCCH-HHHHHHHHHHHHHCCC------------------------------------- T ss_conf 76530001----02555302245657-8999999998752146------------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHH Q ss_conf 5321368887532678950799961875567888635885568999999999999871841255212332103456 Q Fun_An_XP_0013 209 GPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSL 284 (523) Q Consensus 209 ~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~L 284 (523) ++|++||.+|+| |++.+.-..++ ++.++-++|+..|.+|.+...+.+.| T Consensus 108 ----------------~~piiivgnK~D----l~~~~~i~~~~-------~~~~~~~~~~~~~e~Sa~~~~~i~e~ 156 (167) T e1z08a1 108 ----------------EICLCIVGNKID----LEKERHVSIQE-------AESYAESVGAKHYHTSAKQNKGIEEL 156 (167) T ss_pred ----------------CCCEEEEEECCC----CCCCCCCCHHH-------HHHHHHHCCCCEEEEECCCCCCHHHH T ss_conf ----------------742256762334----55455679899-------99999973993899961589788899 No 31 >d1r2qa_ c.37.1.8 (A:) Rab5a {Human (Homo sapiens)} SCOP: d1n6oa_ d1tu4a_ d1n6la_ d1tu4d_ d1n6ka_ d1n6ha_ d1tu3c_ d1tu3b_ d1n6na_ d1n6ra_ d1tu4b_ d1n6pa_ d1tu3d_ u1z0da1 d1huqa_ u1z07a1 Probab=97.95 E-value=0.0022 Score=44.41 Aligned_columns=160 Identities=14% Q ss_pred HCCCCCEEEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCC Q ss_conf 04884204788647798732123233111124556631225656744443342022331000677455110167871788 Q Fun_An_XP_0013 41 GKRLPEKNLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEP 120 (523) Q Consensus 41 ~~rlpsKnilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~ 120 (523) +++.+.-.|+++|..+.||+||+..+...+... .....- +.+|....+...+.. .++.+|-. .| T Consensus 1 ~~~~~~~Ki~ivG~~~vGKTsli~~~~~~~~~~----~~~~t~--------~~~~~~~~~~~~~~~---~~~~i~D~-~g 64 (170) T d1r2qa_ 1 GNKICQFKLVLLGESAVGKSSLVLRFVKGQFHE----FQESTI--------GAAFLTQTVCLDDTT---VKFEIWDT-AG 64 (170) T ss_dssp CCEEEEEEEEEECSTTSSHHHHHHHHHHSCCCT----TCCCCS--------SEEEEEEEEEETTEE---EEEEEEEE-CC T ss_pred CCCCCEEEEEEEECCCCCHHHHHHHHHCCCCCC----CCCCEE--------EEEEEEEEEEECCEE---EEEEEECC-CC T ss_conf 987522689998279977999999986481255----635303--------567777656556907---99987427-77 Q ss_pred CHHHHHHHHHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCC Q ss_conf 71123200110581012003343330000313689999999999999985069588899999999986226887677777 Q Fun_An_XP_0013 121 SLSFAPLLKPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGG 200 (523) Q Consensus 121 d~~~~~LLk~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~ 200 (523) ...+..+.+..+..- ..++++.|.+.+.++-. +..|+..+...... T Consensus 65 ~~~~~~~~~~~~~~~----~~~i~v~d~~~~~s~~~-~~~~~~~~~~~~~~----------------------------- 110 (170) T d1r2qa_ 65 QERYHSLAPMYYRGA----QAAIVVYDITNEESFAR-AKNWVKELQRQASP----------------------------- 110 (170) T ss_dssp SGGGGGGHHHHHTTC----SEEEEEEETTCHHHHHH-HHHHHHHHHHHSCT----------------------------- T ss_pred CHHHHHHHHHHCCCC----CEEEEEEECCCHHHHHH-HHHHHHHHHHHHHC----------------------------- T ss_conf 303445412102688----67999830652035888-98889999886405----------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCC Q ss_conf 67777664532136888753267895079996187556788863588556899999999999987184125521233210 Q Fun_An_XP_0013 201 AQGFTSSAGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANS 280 (523) Q Consensus 201 ~~~~~~s~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~n 280 (523) .+|+++|.+|+| |+.+.....++ ++.|+-++++.++.||.+...+ T Consensus 111 ------------------------~~piilv~nK~D----l~~~~~i~~~~-------~~~~~~~~~~~~~e~Sak~g~g 155 (170) T d1r2qa_ 111 ------------------------NIVIALSGNKAD----LANKRAVDFQE-------AQSYADDNSLLFMETSAKTSMN 155 (170) T ss_dssp ------------------------TCEEEEEEECGG----GGGGCCSCHHH-------HHHHHHHTTCEEEECCTTTCTT T ss_pred ------------------------CCCEEEEECCHH----HHHHCCCCHHH-------HHHHHHHCCCEEEEEECCCCCC T ss_conf ------------------------861244303211----01003658789-------9999985598399986168978 Q ss_pred HHHHH Q ss_conf 34565 Q Fun_An_XP_0013 281 LQSLI 285 (523) Q Consensus 281 l~~Ll 285 (523) ...|. T Consensus 156 i~elf 160 (170) T d1r2qa_ 156 VNEIF 160 (170) T ss_dssp HHHHH T ss_pred HHHHH T ss_conf 88999 No 32 >cd01868 Rab11_like Rab11-like. Rab11a, Rab11b, and Rab25 are closely related, evolutionary conserved Rab proteins that are differentially expressed. Rab11a is ubiquitously synthesized, Rab11b is enriched in brain and heart and Rab25 is only found in epithelia. Rab11/25 proteins seem to regulate recycling pathways from endosomes to the plasma membrane and to the trans-Golgi network. Furthermore, Rab11a is thought to function in the histamine-induced fusion of tubulovesicles containing H+, K+ ATPase with the plasma membrane in gastric parietal cells and in insulin-stimulated insertion of GLUT4 in the plasma membrane of cardiomyocytes. Overexpression of Rab25 has recently been observed in ovarian cancer and breast cancer, and has been correlated with worsened outcomes in both diseases. In addition, Rab25 overexpression has also been observed in prostate cancer, transitional cell carcinoma of the bladder, and invasive breast tumor cells. GTPase activating proteins (GAPs) interact with GTP Probab=97.95 E-value=0.0009 Score=46.95 Aligned_columns=155 Identities=17% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|..+.||++|+..+...+-.. +..- -+|..|....= ..++....+.+|=.+..+.+ T Consensus 6 i~~iG~~~VGKTsli~r~~~~~F~~----~~~~----------Tig~~~~~k~v-~~~~~~~~l~iwDtaG~e~~----- 65 (165) T cd01868 6 IVLIGDSGVGKSNLLSRFTRNEFNL----DSKS----------TIGVEFATRSI-QIDGKTIKAQIWDTAGQERY----- 65 (165) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCC----CCCC----------CEEEEEEEEEE-EECCEEEEEEEECCCCCHHH----- T ss_conf 9998269965899999986385674----5564----------10012468898-64890899998538986124----- Q ss_pred HHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 110581012003-3433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 129 KPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 129 k~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) ..+.+..++++ .++|+-|.+.+.+| +.+.+|+..++++..+ T Consensus 66 -~~~~~~~~~~a~~~iivyDit~~~Sf-~~i~~w~~~i~~~~~~------------------------------------ 107 (165) T cd01868 66 -RAITSAYYRGAVGALLVYDITKKQTF-ENVERWLKELRDHADS------------------------------------ 107 (165) T ss_pred -HHHHHHHHCCCCEEEEEEECCCHHHH-HHHHHHHHHHHHHCCC------------------------------------ T ss_conf -57767650488679999746997789-9999999999983289------------------------------------ Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHH Q ss_conf 45321368887532678950799961875567888635885568999999999999871841255212332103456553 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIHS 287 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh~ 287 (523) .+|+++|.+|+| |+..+.... +-.+.+|.++|+..|-||++...|.+.+.+. T Consensus 108 -----------------~~piilVGNK~D----L~~~r~v~~-------~e~~~~a~~~~~~~~e~Sak~g~ni~~~F~~ 159 (165) T cd01868 108 -----------------NIVIMLVGNKSD----LRHLRAVPT-------EEAKAFAEKNGLSFIETSALDGTNVEEAFKQ 159 (165) T ss_pred -----------------CCEEEEEECCCC----HHHCCCCCH-------HHHHHHHHHCCCCEEEEECCCCCCHHHHHHH T ss_conf -----------------937999821656----212037768-------8999999965994999971479888899999 Q ss_pred HC Q ss_conf 22 Q Fun_An_XP_0013 288 SL 289 (523) Q Consensus 288 ~l 289 (523) .. T Consensus 160 l~ 161 (165) T cd01868 160 LL 161 (165) T ss_pred HH T ss_conf 99 No 33 >cd00876 Ras Ras family. The Ras family of the Ras superfamily includes classical N-Ras, H-Ras, and K-Ras, as well as R-Ras, Rap, Ral, Rheb, Rhes, ARHI, RERG, Rin/Rit, RSR1, RRP22, Ras2, Ras-dva, and RGK proteins. Ras proteins regulate cell growth, proliferation and differentiation. Ras is activated by guanine nucleotide exchange factors (GEFs) that release GDP and allow GTP binding. Many RasGEFs have been identified. These are sequestered in the cytosol until activation by growth factors triggers recruitment to the plasma membrane or Golgi, where the GEF colocalizes with Ras. Active GTP-bound Ras interacts with several effector proteins: among the best characterized are the Raf kinases, phosphatidylinositol 3-kinase (PI3K), RalGEFs and NORE/MST1. Most Ras proteins contain a lipid modification site at the C-terminus, with a typical sequence motif CaaX, where a = an aliphatic amino acid and X = any amino acid. Lipid binding is essential for membrane attachment, a key feature of m Probab=97.95 E-value=0.00064 Score=47.90 Aligned_columns=152 Identities=17% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|..+.||++|+..+...+-.. ++.. ..+-.| ...-..++...++.+|=. .|...+ T Consensus 2 i~~iGd~~vGKTsli~r~~~~~f~~----~~~~----------ti~~~~--~k~~~~~~~~~~l~i~Dt-~G~e~~---- 60 (160) T cd00876 2 VVVLGAGGVGKSAITIQFVKGTFVE----EYDP----------TIEDSY--RKTIVVDGETYTLDILDT-AGQEEF---- 60 (160) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCC----CCCC----------CHHHEE--EEEEEECCEEEEEEEEEC-CCCHHH---- T ss_conf 7888079966899999987281067----5354----------200226--778888482899998635-884133---- Q ss_pred HHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 110581012003-3433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 129 KPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 129 k~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) ..+.+..+++. .++|+.|-+.+.+| +.+++|...+++....- T Consensus 61 -~~~~~~~~~~a~~~iivfdi~~~~Sf-~~i~~w~~~i~~~~~~~----------------------------------- 103 (160) T cd00876 61 -SAMRDLYIRQGDGFILVYSITDRESF-EEIKGYREQILRVKDDE----------------------------------- 103 (160) T ss_pred -HHHHHHHHCCCCEEEEEEECCCHHHH-HHHHHHHHHHHHHCCCC----------------------------------- T ss_conf -46888764046178999866997799-99999999999853899----------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHH Q ss_conf 4532136888753267895079996187556788863588556899999999999987184125521233210345655 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIH 286 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh 286 (523) .+|+++|++|+| |..++-...++ .+.|+-++|+..|.||++...|...+.. T Consensus 104 -----------------~~piilvgNK~D----l~~~r~v~~~e-------~~~~a~~~~~~~~e~Sak~~~nV~~~F~ 154 (160) T cd00876 104 -----------------DIPIVLVGNKCD----LENERQVSKEE-------GKALAKEWGCPFIETSAKDNINIDEVFK 154 (160) T ss_pred -----------------CCEEEEEECCCC----CHHHCCCCHHH-------HHHHHHHCCCCEEEEEECCCCCHHHHHH T ss_conf -----------------967999821326----30011676889-------9999996499699997048988889999 No 34 >cd04141 Rit_Rin_Ric Rit/Rin/Ric subfamily. Rit (Ras-like protein in all tissues), Rin (Ras-like protein in neurons) and Ric (Ras-related protein which interacts with calmodulin) form a subfamily with several unique structural and functional characteristics. These proteins all lack a the C-terminal CaaX lipid-binding motif typical of Ras family proteins, and Rin and Ric contain calmodulin-binding domains. Rin, which is expressed only in neurons, induces neurite outgrowth in rat pheochromocytoma cells through its association with calmodulin and its activation of endogenous Rac/cdc42. Rit, which is ubiquitously expressed in mammals, inhibits growth-factor withdrawl-mediated apoptosis and induces neurite extension in pheochromocytoma cells. Rit and Rin are both able to form a ternary complex with PAR6, a cell polarity-regulating protein, and Rac/cdc42. This ternary complex is proposed to have physiological function in processes such as tumorigenesis. Activated Ric is likely to sign Probab=97.93 E-value=0.00084 Score=47.12 Aligned_columns=168 Identities=21% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|..+.||++|+...-... ....-.|-|++.|.....+ ++...++.+|=. .|...|..|. T Consensus 5 i~liGd~~VGKTsli~rf~~~~--------F~~~y~pTi~~~~~~~i~~--------~~~~v~l~iwDt-aGqe~~~~l~ 67 (172) T cd04141 5 IVMLGAGGVGKSAVTMQFISHS--------FPDYHDPTIEDAYKQQARI--------DNEPALLDILDT-AGQAEFTAMR 67 (172) T ss_pred EEEEECCCCCHHHHHHHHHCCC--------CCCCCCCCCEEEEEEEEEE--------CCEEEEEEEECC-CCCHHHHHHH T ss_conf 9997079843899999987282--------2776566300004789989--------795899986227-7621355676 Q ss_pred HHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC Q ss_conf 11058101200334333000031368999999999999998506958889999999998622688767777767777664 Q Fun_An_XP_0013 129 KPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSSA 208 (523) Q Consensus 129 k~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s~ 208 (523) +..+.--. .+||+-|-+++-+| +.+..|...+...-..- T Consensus 68 ~~~~~~a~----~~ilVyditd~~Sf-~~i~~w~~~i~~~~~~~------------------------------------ 106 (172) T cd04141 68 DQYMRCGE----GFIICYSVTDRHSF-QEASEFKKLITRVRLTE------------------------------------ 106 (172) T ss_pred HHHCCCCC----EEEEEEECCCHHHH-HHHHHHHHHHHHHCCCC------------------------------------ T ss_conf 87514997----38998542897689-99999999999740799------------------------------------ Q ss_pred CCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHH Q ss_conf 53213688875326789507999618755678886358855689999999999998718412552123321034565532 Q Fun_An_XP_0013 209 GPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIHSS 288 (523) Q Consensus 209 ~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh~~ 288 (523) .+|+++|.+||| |+.++.-..++ .+.+|=++|+..|-||++...|...+.+.. T Consensus 107 ----------------~~pivlvgNK~D----L~~~r~V~~~e-------~~~~a~~~~~~f~EtSAk~~~nV~~~F~~l 159 (172) T cd04141 107 ----------------DIPLVLVGNKVD----LESQRQVTTEE-------GRNLAREFNCPFFETSAALRHYIDDAFHGL 159 (172) T ss_pred ----------------CCEEEEEECCCH----HHHCCCCCHHH-------HHHHHHHCCCCEEEEECCCCCCHHHHHHHH T ss_conf ----------------977999815601----65415667789-------999999659969999705898878999999 Q ss_pred CCCCCCCCCCCCCCC Q ss_conf 253224667551123 Q Fun_An_XP_0013 289 LGIHSLLKRQSLKHN 303 (523) Q Consensus 289 lgih~ll~~~~~~a~ 303 (523) +..+.++++++|. T Consensus 160 --~~~i~~k~~~p~~ 172 (172) T cd04141 160 --VREIRRKESMPAL 172 (172) T ss_pred --HHHHHHHCCCCCC T ss_conf --9999971778789 No 35 >1r2q_A RAS-related protein RAB-5A; GTPase, GNP, atomic resolution; HET: GNP; 1.05A {Homo sapiens} SCOP: c.37.1.8 Probab=97.93 E-value=0.0024 Score=44.15 Aligned_columns=169 Identities=13% Q ss_pred HCCCCCEEEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCC Q ss_conf 04884204788647798732123233111124556631225656744443342022331000677455110167871788 Q Fun_An_XP_0013 41 GKRLPEKNLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEP 120 (523) Q Consensus 41 ~~rlpsKnilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~ 120 (523) +++++.-.|+|+|..+.||++|+..+....... .... .++..+....-...... .++.+|-. .| T Consensus 1 ~~~~~~yKv~viG~~~vGKTsLi~~~~~~~~~~----~~~~----------t~~~~~~~~~~~~~~~~-~~l~i~d~-~g 64 (170) T 1r2q_A 1 GNKICQFKLVLLGESAVGKSSLVLRFVKGQFHE----FQES----------TIGAAFLTQTVCLDDTT-VKFEIWDT-AG 64 (170) T ss_dssp CCEEEEEEEEEECSTTSSHHHHHHHHHHSCCCT----TCCC----------CSSEEEEEEEEEETTEE-EEEEEEEE-CC T ss_pred CCCCCEEEEEEEECCCCCHHHHHHHHHCCCCCC----CCCC----------CCCCCCEEEECCCCCCE-EEEEEECC-CC T ss_conf 986403789998179977899999986480155----4354----------00111001221478846-89987215-56 Q ss_pred CHHHHHHHHHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCC Q ss_conf 71123200110581012003343330000313689999999999999985069588899999999986226887677777 Q Fun_An_XP_0013 121 SLSFAPLLKPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGG 200 (523) Q Consensus 121 d~~~~~LLk~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~ 200 (523) ...+..+.+..+. .-..++++.|.+.|+++ +.+.+|+..++.+... T Consensus 65 ~~~~~~~~~~~~~----~~~~~i~v~d~~~~~s~-~~~~~~~~~i~~~~~~----------------------------- 110 (170) T 1r2q_A 65 QERYHSLAPMYYR----GAQAAIVVYDITNEESF-ARAKNWVKELQRQASP----------------------------- 110 (170) T ss_dssp SGGGGGGHHHHHT----TCSEEEEEEETTCHHHH-HHHHHHHHHHHHHSCT----------------------------- T ss_pred CCHHHHHHHHHHC----CCCEEEEEEECCCCCCC-HHHHHHHHHHHHHHCC----------------------------- T ss_conf 3201133267523----77548998405555343-0144556655332037----------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCC Q ss_conf 67777664532136888753267895079996187556788863588556899999999999987184125521233210 Q Fun_An_XP_0013 201 AQGFTSSAGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANS 280 (523) Q Consensus 201 ~~~~~~s~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~n 280 (523) ++|+++|.+|+| |..++.-..++ ++.+|-++|+..|.||.+...+ T Consensus 111 ------------------------~~piilvgnK~D----l~~~~~v~~~~-------~~~~a~~~~~~~~~~Sak~g~~ 155 (170) T 1r2q_A 111 ------------------------NIVIALSGNKAD----LANKRAVDFQE-------AQSYADDNSLLFMETSAKTSMN 155 (170) T ss_dssp ------------------------TCEEEEEEECGG----GGGGCCSCHHH-------HHHHHHHTTCEEEECCTTTCTT T ss_pred ------------------------CCCEEECCCCCC----HHHHHHHHHHH-------HHHHHHHCCCEEEEEECCCCCC T ss_conf ------------------------822441346430----13343102444-------4357886596289986278978 Q ss_pred HHHHHHHHCCCCCCCC Q ss_conf 3456553225322466 Q Fun_An_XP_0013 281 LQSLIHSSLGIHSLLK 296 (523) Q Consensus 281 l~~Llh~~lgih~ll~ 296 (523) ...|.... +..+.+ T Consensus 156 i~elf~~l--~~~i~~ 169 (170) T 1r2q_A 156 VNEIFMAI--AKKLPK 169 (170) T ss_dssp HHHHHHHH--HHTSCC T ss_pred HHHHHHHH--HHHHHC T ss_conf 88999999--999622 No 36 >e1x1ra1 c.37.1.8 (A:10-178) Ras-related protein M-Ras (XRas) {Mouse (Mus musculus) [TaxID:10090]} SCOP: u1x1sa_ Probab=97.93 E-value=0.00083 Score=47.16 Aligned_columns=161 Identities=17% Q ss_pred CCCEEEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHH Q ss_conf 84204788647798732123233111124556631225656744443342022331000677455110167871788711 Q Fun_An_XP_0013 44 LPEKNLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLS 123 (523) Q Consensus 44 lpsKnilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~ 123 (523) ||+=-|+|+|....||+||+..+...............-. ..++.+.+.. -.+.+|-. .|... T Consensus 2 ~~~~Ki~iiG~~~vGKTsli~~~~~~~~~~~~~~t~~~~~-----------~~~~~~~~~~-----~~~~i~D~-~g~~~ 64 (169) T e1x1ra1 2 LPTYKLVVVGDGGVGKSALTIQFFQKIFVPDYDPTIEDSY-----------LKHTEIDNQW-----AILDVLDT-AGQEE 64 (169) T ss_pred CCEEEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEECC-----------EEEEEECCEE-----EEEEEEEE-CCCCC T ss_conf 9748899982699878999999862723766564200021-----------1589971337-----78778760-57653 Q ss_pred HHHHHHHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCC Q ss_conf 23200110581012003343330000313689999999999999985069588899999999986226887677777677 Q Fun_An_XP_0013 124 FAPLLKPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQG 203 (523) Q Consensus 124 ~~~LLk~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~ 203 (523) +..+.+..+.. -..++|+.|.+.++++-. +.+|+..+......- T Consensus 65 ~~~~~~~~~~~----~~~~ilv~d~~~~~s~~~-~~~~~~~i~~~~~~~------------------------------- 108 (169) T e1x1ra1 65 FSAMREQYMRT----GDGFLIVYSVTDKASFEH-VDRFHQLILRVKDRE------------------------------- 108 (169) T ss_pred CHHHHHHHCCC----CEEEEEEEECCCCCCCCC-CHHHHHHHHHHCCCC------------------------------- T ss_conf 20235876069----758999853341000120-004678887531768------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCC-CHH Q ss_conf 7766453213688875326789507999618755678886358855689999999999998718412552123321-034 Q Fun_An_XP_0013 204 FTSSAGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLAN-SLQ 282 (523) Q Consensus 204 ~~~s~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~-nl~ 282 (523) .+|++||++|+| |.+++.-..++ ++.||-++|+..|-||.|..+ |.+ T Consensus 109 ---------------------~~piilvgnK~D----l~~~~~v~~~e-------~~~~~~~~~~~~~e~SAk~~~~nv~ 156 (169) T e1x1ra1 109 ---------------------SFPMILVANKVD----LMHLRKVTRDQ-------GKEMATKYNIPYIETSAKDPPLNVD 156 (169) T ss_pred ---------------------CCCEEEEEECCC----HHHCCCCCHHH-------HHHHHHHCCCCEEEEEECCCCCCHH T ss_conf ---------------------761799951568----10216669899-------9999996599599996145886978 Q ss_pred HHHHHHC Q ss_conf 5655322 Q Fun_An_XP_0013 283 SLIHSSL 289 (523) Q Consensus 283 ~Llh~~l 289 (523) -+....+ T Consensus 157 ~~f~~l~ 163 (169) T e1x1ra1 157 KTFHDLV 163 (169) T ss_pred HHHHHHH T ss_conf 9999999 No 37 >2g3y_A GTP-binding protein GEM; small GTPase, GDP, inactive state, RGK family, structural genomics, structural genomics consortium, SGC; HET: GDP; 2.40A {Homo sapiens} SCOP: c.37.1.8 Probab=97.93 E-value=0.0015 Score=45.42 Aligned_columns=174 Identities=19% Q ss_pred HHHHHHHHHCCCCCEEEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEE Q ss_conf 98887664048842047886477987321232331111245566312256567444433420223310006774551101 Q Fun_An_XP_0013 33 SMLDSVANGKRLPEKNLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARV 112 (523) Q Consensus 33 siL~~vss~~rlpsKnilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~ 112 (523) +.+..+++...-+.=.|+|+|..+.||++|+..+.+.. .......++ ...-.|.-...-| -.++ T Consensus 24 ~~~~~~~~~~~~~~~KI~lvG~~~vGKSsLi~rl~~~~-------~~~~~~~~~-----~~~~~~~~~i~~d----~~~~ 87 (211) T 2g3y_A 24 STDSVISSESGNTYYRVVLIGEQGVGKSTLANIFAGVH-------DSMDSDCEV-----LGEDTYERTLMVD----GESA 87 (211) T ss_dssp -----------CCEEEEEEECCTTSSHHHHHHHHHCCC-------CTTCCC--------CCTTEEEEEEEET----TEEE T ss_pred CCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHCCC-------CCCCCCCCC-----EEEEEEEEEEEEC----CCEE T ss_conf 22211356788825899998289865889887775265-------532543575-----1788899999634----8616 Q ss_pred EEEEECCCCHHHHHHHHHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC Q ss_conf 6787178871123200110581012003-343330000313689999999999999985069588899999999986226 Q Fun_An_XP_0013 113 SAYLLSEPSLSFAPLLKPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRK 191 (523) Q Consensus 113 svyiL~d~d~~~~~LLk~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~ 191 (523) .++++.=.|.+ +.-.| +....++.+ .++|+.|.+++.+ ++.+.+|..-++++...- T Consensus 88 ~~~~~~i~d~~--g~e~~-~~~~~~~~~d~~ilvfD~~~~~S-~~~i~~~~~~i~~~~~~~------------------- 144 (211) T 2g3y_A 88 TIILLDMWENK--GENEW-LHDHCMQVGDAYLIVYSITDRAS-FEKASELRIQLRRARQTE------------------- 144 (211) T ss_dssp EEEEECCTTTT--HHHHH-HHHCCCCCCSEEEEEEETTCHHH-HHHHHHHHHHHHTSGGGT------------------- T ss_pred EEEEEECCCCC--CCCCC-CCHHHHCCCEEEEEEEEEECCCC-CCCCCCCCEEEEECCCCC------------------- T ss_conf 89986111011--00000-11122203403443443210454-232212310000013445------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEE Q ss_conf 88767777767777664532136888753267895079996187556788863588556899999999999987184125 Q Fun_An_XP_0013 192 RGMDSSSGGAQGFTSSAGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLI 271 (523) Q Consensus 192 ~~~~~~~~~~~~~~~s~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLi 271 (523) .+|++||.+||| |..+.....++ .+.|+-++|+..+ T Consensus 145 ---------------------------------~~piiivgnK~D----l~~~~~i~~~e-------~~~~~~~~~~~~~ 180 (211) T 2g3y_A 145 ---------------------------------DIPIILVGNKSD----LVRCREVSVSE-------GRACAVVFDCKFI 180 (211) T ss_dssp ---------------------------------TSCEEEEEECTT----CGGGCCSCHHH-------HHHHHHHHTCEEE T ss_pred ---------------------------------CEEEEEEECCCC----CCCCCCCCHHH-------HHHHHHHCCCCEE T ss_conf ---------------------------------168999702578----00104678899-------9999996499389 Q ss_pred EECCCCCCCHHHHHHHHC Q ss_conf 521233210345655322 Q Fun_An_XP_0013 272 YTTPFLANSLQSLIHSSL 289 (523) Q Consensus 272 YTS~~~~~nl~~Llh~~l 289 (523) -+|.+...++..+.+... T Consensus 181 e~SAk~g~gI~elf~~i~ 198 (211) T 2g3y_A 181 ETSAAVQHNVKELFEGIV 198 (211) T ss_dssp ECBTTTTBSHHHHHHHHH T ss_pred EEECCCCCCHHHHHHHHH T ss_conf 997048868889999999 No 38 >2fn4_A P23, RAS-related protein R-RAS; GDP/GTP binding, GTP hydrolysis, structural genomics, structural genomics consortium, SGC; HET: GDP; 1.65A {Homo sapiens} SCOP: c.37.1.8 Probab=97.93 E-value=0.0019 Score=44.78 Aligned_columns=156 Identities=18% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+|+|..+.||+||+..+.+..... .... ..+-.|.....-|... -++.+|-. .+...+..+. T Consensus 12 I~viG~~~vGKTsLi~~l~~~~~~~----~~~~----------t~~~~~~~~~~~~~~~--i~~~i~d~-~~~~~~~~~~ 74 (181) T 2fn4_A 12 LVVVGGGGVGKSALTIQFIQSYFVS----DYDP----------TIEDSYTKICSVDGIP--ARLDILDT-AGQEEFGAMR 74 (181) T ss_dssp EEEEECTTSSHHHHHHHHHHSSCCS----SCCT----------TCCEEEEEEEEETTEE--EEEEEEEC-CCTTTTSCCH T ss_pred EEEEECCCCCHHHHHHHHHCCCCCC----CCCC----------EEEEEEEEEECCCCEE--EEEEEECC-CCCHHHHHHH T ss_conf 9998079987999999986382367----6354----------1577665553368827--99886024-5720110001 Q ss_pred HHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC Q ss_conf 11058101200334333000031368999999999999998506958889999999998622688767777767777664 Q Fun_An_XP_0013 129 KPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSSA 208 (523) Q Consensus 129 k~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s~ 208 (523) +..+..-. .++++.|.+.+.+ .+.+.+|...+....... T Consensus 75 ~~~~~~~~----~~i~v~d~~~~~s-~~~~~~~~~~~~~~~~~~------------------------------------ 113 (181) T 2fn4_A 75 EQYMRAGH----GFLLVFAINDRQS-FNEVGKLFTQILRVKDRD------------------------------------ 113 (181) T ss_dssp HHHHHHCS----EEEEEEETTCHHH-HHHHHHHHHHHHHHHTSS------------------------------------ T ss_pred HHHHCCHH----HEEEEEEECCCCH-HHHHHHHHHHHHHHCCCC------------------------------------ T ss_conf 22200001----0233100012100-234432232222110157------------------------------------ Q ss_pred CCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHH Q ss_conf 53213688875326789507999618755678886358855689999999999998718412552123321034565532 Q Fun_An_XP_0013 209 GPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIHSS 288 (523) Q Consensus 209 ~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh~~ 288 (523) ++|+++|++|+| |+.++....+. ++.++.++++..|.||.+...++..+.+.. T Consensus 114 ----------------~~piilvgnK~D----l~~~~~~~~~~-------~~~~~~~~~~~~~e~Sak~~~~v~~~f~~l 166 (181) T 2fn4_A 114 ----------------DFPVVLVGNKAD----LESQRQVPRSE-------ASAFGASHHVAYFEASAKLRLNVDEAFEQL 166 (181) T ss_dssp ----------------CCCEEEEEECGG----GGGGCCSCHHH-------HHHHHHHTTCEEEECBTTTTBSHHHHHHHH T ss_pred ----------------CCEEEEEECCCC----CHHHHHHHHHH-------HHHHHHHCCCCEEEEEECCCCCHHHHHHHH T ss_conf ----------------850799706655----10233104788-------889998708727999605898888999999 Q ss_pred C Q ss_conf 2 Q Fun_An_XP_0013 289 L 289 (523) Q Consensus 289 l 289 (523) + T Consensus 167 ~ 167 (181) T 2fn4_A 167 V 167 (181) T ss_dssp H T ss_pred H T ss_conf 9 No 39 >1oix_A RAS-related protein RAB-11A; small G protein, intracellular trafficking, GTP-binding, lipoprotein, prenylation, protein transport; HET: GDP; 1.7A {Homo sapiens} SCOP: c.37.1.8 Probab=97.92 E-value=0.0012 Score=46.02 Aligned_columns=156 Identities=17% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+|+|....||++|+..+....... .....- +..+....+...+.. -.+.+|-. .+...+..+. T Consensus 32 I~iiG~~~vGKSSLi~~l~~~~~~~----~~~~t~--------~~~~~~~~~~~~~~~---~~~~i~d~-~g~~~~~~~~ 95 (191) T 1oix_A 32 VVLIGDSGVGKSNLLSRFTRNEFNL----ESKSTI--------GVEFATRSIQVDGKT---IKAQIWDT-AGLERYRAIT 95 (191) T ss_dssp EEEEECTTSSHHHHHHHHHHSCCCC----SCCCCC--------SEEEEEEEEEETTEE---EEEEEEEE-CSCCSSSCCC T ss_pred EEEEECCCCCHHHHHHHHHCCCCCC----CCCCCC--------CCCCCEEEEEEECEE---EEEEEECC-CCCHHHHHHH T ss_conf 9998179977899999986482564----443321--------220110268750213---44455147-7720234567 Q ss_pred HHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC Q ss_conf 11058101200334333000031368999999999999998506958889999999998622688767777767777664 Q Fun_An_XP_0013 129 KPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSSA 208 (523) Q Consensus 129 k~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s~ 208 (523) +..+..-.+ ++++.|.+.+.+ ++.+.+|...++..... T Consensus 96 ~~~~~~~d~----iilv~d~~~~~S-~~~~~~~~~~i~~~~~~------------------------------------- 133 (191) T 1oix_A 96 SAYYRGAVG----ALLVYDIAKHLT-YENVERWLKELRDHADS------------------------------------- 133 (191) T ss_dssp HHHHTTCCE----EEEEEETTCHHH-HHTHHHHHHHHHHHSCT------------------------------------- T ss_pred HHHCCCCCE----EEEEEEECCCCC-HHHHHHHHHHHHHHCCC------------------------------------- T ss_conf 764136765----899975077530-68999988877763289------------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHH Q ss_conf 53213688875326789507999618755678886358855689999999999998718412552123321034565532 Q Fun_An_XP_0013 209 GPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIHSS 288 (523) Q Consensus 209 ~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh~~ 288 (523) .+|+++|++|+| |.+++.-..++ ++.||-+++...+.||.+...+...+.... T Consensus 134 ----------------~~piiivgnK~D----l~~~~~i~~~e-------~~~~~~~~~~~~~evSak~~~~I~elf~~i 186 (191) T 1oix_A 134 ----------------NIVIMLVGNKSD----LRHLRAVPTDE-------ARAFAEKNGLSFIETSALDSTNVEAAFQTI 186 (191) T ss_dssp ----------------TCEEEEEEECGG----GGGGCCSCHHH-------HHHHHHHTTCEEEECCTTTCTTHHHHHHHH T ss_pred ----------------CCEEEEEECCCC----CCCCCCCCHHH-------HHHHHHHCCCCEEEEECCCCCCHHHHHHHH T ss_conf ----------------977999841433----00003688899-------999999639938999616886888999999 Q ss_pred C Q ss_conf 2 Q Fun_An_XP_0013 289 L 289 (523) Q Consensus 289 l 289 (523) + T Consensus 187 ~ 187 (191) T 1oix_A 187 L 187 (191) T ss_dssp H T ss_pred H T ss_conf 9 No 40 >1ky3_A GTP-binding protein YPT7P; vesicular traffic, GTP hydrolysis, YPT/RAB protein, endocytosis, hydrolase; HET: GDP; 1.35A {Saccharomyces cerevisiae} SCOP: c.37.1.8 Probab=97.92 E-value=0.0016 Score=45.31 Aligned_columns=160 Identities=18% Q ss_pred EEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHH Q ss_conf 47886477987321232331111245566312256567444433420223310006774551101678717887112320 Q Fun_An_XP_0013 48 NLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPL 127 (523) Q Consensus 48 nilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~L 127 (523) .|+++|..+.||+||+..|.+..... .... .++..+.........+..-.+..|.. .+...+..+ T Consensus 10 kI~iiG~~~vGKTsLl~~l~~~~~~~----~~~~----------t~~~~~~~~~~~~~~~~~~~~~i~~~-~~~~~~~~~ 74 (182) T 1ky3_A 10 KVIILGDSGVGKTSLMHRYVNDKYSQ----QYKA----------TIGADFLTKEVTVDGDKVATMQVWDT-AGQERFQSL 74 (182) T ss_dssp EEEEECCTTSSHHHHHHHHHHSCCCT----TC-------------CCCSCEEEEECCSSSCCEEEEEECC-C-------- T ss_pred EEEEEECCCCCHHHHHHHHHCCCCCC----CCCC----------CEEEEEEEEEEEECCCEEEEEEEECC-CCCHHCCCC T ss_conf 99998079987999999986580156----6345----------04556888888753837999986035-210000121 Q ss_pred HHHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 01105810120033433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 128 LKPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 128 Lk~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) .+..+. .-..++++.|.+.++++ +.+.+|..-+..+...-..+ T Consensus 75 ~~~~~~----~~~~~i~v~d~~~~~s~-~~~~~~~~~i~~~~~~~~~~-------------------------------- 117 (182) T 1ky3_A 75 GVAFYR----GADCCVLVYDVTNASSF-ENIKSWRDEFLVHANVNSPE-------------------------------- 117 (182) T ss_dssp --CCST----TCCEEEEEEETTCHHHH-HTHHHHHHHHHHHHCCSCTT-------------------------------- T ss_pred CHHHHC----CCEEEEEEEECCCCCHH-HHHHHHHHHHHHHHHHCCCC-------------------------------- T ss_conf 034412----42058998603671012-22335678899886412789-------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHC-CEEEEECCCCCCCHHHHHH Q ss_conf 453213688875326789507999618755678886358855689999999999998718-4125521233210345655 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHG-ASLIYTTPFLANSLQSLIH 286 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYG-AsLiYTS~~~~~nl~~Llh 286 (523) ++|++||++|+|..+ .++....++ ++.||-+|| ...|.||.+...++..|.. T Consensus 118 -----------------~~piiiv~nK~Dl~~--~~~~~~~~~--------~~~~~~~~~~~~~~e~Sa~~~~gi~elf~ 170 (182) T 1ky3_A 118 -----------------TFPFVILGNKIDAEE--SKKIVSEKS--------AQELAKSLGDIPLFLTSAKNAINVDTAFE 170 (182) T ss_dssp -----------------TCCEEEEEECTTSCG--GGCCSCHHH--------HHHHHHHTTSCCEEEEBTTTTBSHHHHHH T ss_pred -----------------CEEEEEEECCCCHHH--HHCCCCHHH--------HHHHHHHCCCCEEEEEECCCCCCHHHHHH T ss_conf -----------------706885203437234--211243789--------99999970796089986268868889999 No 41 >cd04113 Rab4 Rab4 subfamily. Rab4 has been implicated in numerous functions within the cell. It helps regulate endocytosis through the sorting, recycling, and degradation of early endosomes. Mammalian Rab4 is involved in the regulation of many surface proteins including G-protein-coupled receptors, transferrin receptor, integrins, and surfactant protein A. Experimental data implicate Rab4 in regulation of the recycling of internalized receptors back to the plasma membrane. It is also believed to influence receptor-mediated antigen processing in B-lymphocytes, in calcium-dependent exocytosis in platelets, in alpha-amylase secretion in pancreatic cells, and in insulin-induced translocation of Glut4 from internal vesicles to the cell surface. Rab4 is known to share effector proteins with Rab5 and Rab11. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to p Probab=97.91 E-value=0.00091 Score=46.92 Aligned_columns=151 Identities=13% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|+.+.||++|+..+...+-.. ++.. -+|..|....= +.++...++.+|=. .|.-.+..+. T Consensus 3 iviiGd~~VGKTsli~~~~~~~f~~----~~~~----------Tig~~~~~~~i-~~~~~~~~l~i~Dt-~G~e~~~~l~ 66 (161) T cd04113 3 FIIIGSSGTGKSCLLHRFVENKFKE----DSQH----------TIGVEFGSKII-RVGGKRVKLQIWDT-AGQERFRSVT 66 (161) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCC----CCCC----------CCCCCEEEEEE-EECCEEEEEEEEEC-CCCCHHHHHH T ss_conf 8998269855899999986281066----6564----------10120135899-88896999998325-8870134555 Q ss_pred HHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC Q ss_conf 11058101200334333000031368999999999999998506958889999999998622688767777767777664 Q Fun_An_XP_0013 129 KPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSSA 208 (523) Q Consensus 129 k~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s~ 208 (523) +..+..-. .++|+-|.+.+.+| +.+++|+.-+|..... T Consensus 67 ~~~~~~a~----~~iivydi~~~~Sf-~~i~~w~~~~~~~~~~------------------------------------- 104 (161) T cd04113 67 RSYYRGAA----GALLVYDITNRTSF-EALPTWLSDARALASP------------------------------------- 104 (161) T ss_pred HHHCCCCC----EEEEEEECCCHHHH-HHHHHHHHHHHHHCCC------------------------------------- T ss_conf 86426997----79999855986689-9999999999872489------------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHH Q ss_conf 5321368887532678950799961875567888635885568999999999999871841255212332103456 Q Fun_An_XP_0013 209 GPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSL 284 (523) Q Consensus 209 ~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~L 284 (523) .+|+++|++||| |+.++....++ .+.+|.++|...|.||++...|.+.+ T Consensus 105 ----------------~~~iilvgNK~D----L~~~r~v~~~e-------~~~~a~~~~~~~~e~Sak~~~ni~e~ 153 (161) T cd04113 105 ----------------NIVVILVGNKSD----LADQREVTFLE-------ASRFAQENGLLFLETSALTGENVEEA 153 (161) T ss_pred ----------------CCEEEEEECCCC----CCCCCCCCHHH-------HHHHHHHCCCEEEEEECCCCCCHHHH T ss_conf ----------------968999832456----42133458899-------99999965990999971589888899 No 42 >1u8z_A RAS-related protein RAL-A; GNP, GTP, GMPPNP, GPPNHP, GDP, GTPase; HET: GDP; 1.50A {Saguinus oedipus} SCOP: c.37.1.8 Probab=97.90 E-value=0.0016 Score=45.26 Aligned_columns=167 Identities=16% Q ss_pred CCCEEEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHH Q ss_conf 84204788647798732123233111124556631225656744443342022331000677455110167871788711 Q Fun_An_XP_0013 44 LPEKNLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLS 123 (523) Q Consensus 44 lpsKnilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~ 123 (523) +|-.-|+++|..+.||++||..+.+..... +..... +-.|...-..|.. .-++.+|-. .|... T Consensus 2 ~~~~KI~iiG~~~vGKTsLi~~~~~~~~~~----~~~~t~--------~~~~~~~~~~~~~----~~~l~i~d~-~g~~~ 64 (168) T 1u8z_A 2 LALHKVIMVGSGGVGKSALTLQFMYDEFVE----DYEPTK--------ADSYRKKVVLDGE----EVQIDILDT-AGQED 64 (168) T ss_dssp CCEEEEEEECSTTSSHHHHHHHHHHSCCCS----CCCTTC--------CEEEEEEEEETTE----EEEEEEEEC-CC--- T ss_pred CCCEEEEEEECCCCCHHHHHHHHHCCCCCC----CCCCCE--------ECCCEEECCCCCE----EEEEECCCC-CCCHH T ss_conf 660578998279977899999986384476----534320--------1010100256662----464200234-56011 Q ss_pred HHHHHHHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCC Q ss_conf 23200110581012003343330000313689999999999999985069588899999999986226887677777677 Q Fun_An_XP_0013 124 FAPLLKPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQG 203 (523) Q Consensus 124 ~~~LLk~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~ 203 (523) +..+.+.....-.. ++++.|.+.+.++ +.+..|...+......- T Consensus 65 ~~~~~~~~~~~~~~----~i~v~d~~~~~s~-~~~~~~~~~~~~~~~~~------------------------------- 108 (168) T 1u8z_A 65 YAAIRDNYFRSGEG----FLCVFSITEMESF-AATADFREQILRVKEDE------------------------------- 108 (168) T ss_dssp CHHHHHHHHHHCSE----EEEEEETTCHHHH-HHHHHHHHHHHHHHCCT------------------------------- T ss_pred HCCCCCCCHHCCHH----EEEHHHHHCCCCH-HHHHHHHHHHHHCCCCC------------------------------- T ss_conf 12223100001000----0001111100325-78999997543203799------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHH Q ss_conf 77664532136888753267895079996187556788863588556899999999999987184125521233210345 Q Fun_An_XP_0013 204 FTSSAGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQS 283 (523) Q Consensus 204 ~~~s~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~ 283 (523) .+|++||++|+| |+.+..-..++ ++.++.++|+..|.+|++...++.. T Consensus 109 ---------------------~~piiiv~nK~D----l~~~~~v~~~~-------~~~~~~~~~~~~~e~Sa~~~~gi~e 156 (168) T 1u8z_A 109 ---------------------NVPFLLVGNKSD----LEDKRQVSVEE-------AKNRADQWNVNYVETSAKTRANVDK 156 (168) T ss_dssp ---------------------TSCEEEEEECGG----GGGGCCSCHHH-------HHHHHHHHTCEEEECCTTTCTTHHH T ss_pred ---------------------CCEEEEECCCHH----HHHHCCCCHHH-------HHHHHHHCCCCEEEEECCCCCCHHH T ss_conf ---------------------837997145201----23311543789-------9999996599589986168878889 Q ss_pred HHHHHCCCCCCCCC Q ss_conf 65532253224667 Q Fun_An_XP_0013 284 LIHSSLGIHSLLKR 297 (523) Q Consensus 284 Llh~~lgih~ll~~ 297 (523) +.... +..+..| T Consensus 157 ~f~~i--~~~i~~r 168 (168) T 1u8z_A 157 VFFDL--MREIRAR 168 (168) T ss_dssp HHHHH--HHHHHTC T ss_pred HHHHH--HHHHHHC T ss_conf 99999--9999719 No 43 >d1ky3a_ c.37.1.8 (A:) Rab-related protein ypt7p {Baker's yeast (Saccharomyces cerevisiae)} SCOP: d1ky2a_ Probab=97.89 E-value=0.0017 Score=45.16 Aligned_columns=162 Identities=18% Q ss_pred EEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHH Q ss_conf 47886477987321232331111245566312256567444433420223310006774551101678717887112320 Q Fun_An_XP_0013 48 NLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPL 127 (523) Q Consensus 48 nilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~L 127 (523) .|+|+|..+.||+||+..+....... .... .++-.|..............+.+|-. .+...+..+ T Consensus 4 ki~iiG~~~vGKStli~~l~~~~~~~----~~~~----------t~~~~~~~~~~~~~~~~~~~~~i~d~-~~~~~~~~~ 68 (175) T d1ky3a_ 4 KVIILGDSGVGKTSLMHRYVNDKYSQ----QYKA----------TIGADFLTKEVTVDGDKVATMQVWDT-AGQERFQSL 68 (175) T ss_dssp EEEEECCTTSSHHHHHHHHHHSCCCT----TC-------------CCCSCEEEEECCSSSCCEEEEEECC-C-------- T ss_pred EEEEEECCCCCHHHHHHHHHCCCCCC----CCCC----------EEEEEEEEEEEEECCCCEEEEEEECC-CHHHHHHHH T ss_conf 89998079988999999986480156----6145----------16753567777633661489997115-101233110 Q ss_pred HHHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 01105810120033433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 128 LKPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 128 Lk~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) ....+..-. .++++.|.+.+.++-. +..|...++.+...-... T Consensus 69 ~~~~~~~~d----~~ilv~D~~~~~s~~~-~~~~~~~i~~~~~~~~~~-------------------------------- 111 (175) T d1ky3a_ 69 GVAFYRGAD----CCVLVYDVTNASSFEN-IKSWRDEFLVHANVNSPE-------------------------------- 111 (175) T ss_dssp --CCSTTCC----EEEEEEETTCHHHHHT-HHHHHHHHHHHHCCSCTT-------------------------------- T ss_pred HHHHHCCCC----EEEEEEECCCCCCHHH-HHHHHHHHHHHHHHCCCC-------------------------------- T ss_conf 021211110----2244320036561457-777689999986312889-------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHH Q ss_conf 45321368887532678950799961875567888635885568999999999999871841255212332103456553 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIHS 287 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh~ 287 (523) ++|++||++|+|..+ ++..-..++-..|.+.+ .....|.+|.+...++.-+.+. T Consensus 112 -----------------~~Piiiv~nK~Dl~~--~~~~~~~~~~~~~~~~~-------~~~~~~e~Sa~~g~gi~e~f~~ 165 (175) T d1ky3a_ 112 -----------------TFPFVILGNKIDAEE--SKKIVSEKSAQELAKSL-------GDIPLFLTSAKNAINVDTAFEE 165 (175) T ss_dssp -----------------TCCEEEEEECTTSCG--GGCCSCHHHHHHHHHHT-------TSCCEEEEBTTTTBSHHHHHHH T ss_pred -----------------CEEEEEEEECCCCCC--CCCCCCHHHHHHHHHHH-------CCCCEEEEECCCCCCHHHHHHH T ss_conf -----------------727999851246400--02655688999999980-------7971899861688688899999 No 44 >2atx_A Small GTP binding protein TC10; GTPase, P-loop, alpha-beta; HET: GNP; 2.65A {Homo sapiens} SCOP: c.37.1.8 Probab=97.88 E-value=0.0014 Score=45.63 Aligned_columns=161 Identities=14% Q ss_pred EEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHH Q ss_conf 47886477987321232331111245566312256567444433420223310006774551101678717887112320 Q Fun_An_XP_0013 48 NLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPL 127 (523) Q Consensus 48 nilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~L 127 (523) .|+|+|..+.||++|+..+. .+++++--..-....-...+...+.. .++.+|-. .+...+..+ T Consensus 20 Ki~iiG~~~vGKTsli~~~~-------------~~~~~~~~~~t~~~~~~~~i~~~~~~---~~l~i~D~-~g~~~~~~~ 82 (194) T 2atx_A 20 KCVVVGDGAVGKTCLLMSYA-------------NDAFPEEYVPTVFDHYAVSVTVGGKQ---YLLGLYDT-AGQEDYDRL 82 (194) T ss_dssp EEEEEECTTSSHHHHHHHHH-------------HSSCCCSCCCSSCCCEEEEEESSSCE---EEEEEECC-CCSSSSTTT T ss_pred EEEEEECCCCCHHHHHHHHH-------------CCCCCCCCCCEEEEEEEEEEEECCCE---EEEEEECC-CCCCCCHHH T ss_conf 89998179987899999986-------------38437753541654344566534944---88876125-321000012 Q ss_pred HHHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 01105810120033433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 128 LKPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 128 Lk~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) .+..+..-. .++||.|.++++++-.-+.+|+..++.+... T Consensus 83 ~~~~~~~~~----~~ilV~d~~~~~sf~~~~~~~~~~~~~~~~~------------------------------------ 122 (194) T 2atx_A 83 RPLSYPMTD----VFLICFSVVNPASFQNVKEEWVPELKEYAPN------------------------------------ 122 (194) T ss_dssp GGGGCTTCS----EEEEEEETTCHHHHHHHHHTHHHHHHHHSTT------------------------------------ T ss_pred HHHHHCCCE----EEECCCCCCHHHHHHHHHHHHHHHHHHCCCC------------------------------------ T ss_conf 333202010----0200000104678888888766666530678------------------------------------ Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHH---HHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEE-ECCCCCCCHHH Q ss_conf 4532136888753267895079996187556---7888635885568999999999999871841255-21233210345 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKI---EKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIY-TTPFLANSLQS 283 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i---~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiY-TS~~~~~nl~~ 283 (523) +|+++|.+|+|.. ..+++-.+.+..... ....+++|-++|+..|+ ||.+...|.+. T Consensus 123 ------------------~~iilVgnK~Dl~~~~~~~~~~~~~~~~~v~--~~e~~~~a~~~~~~~~~e~Sak~~~~I~~ 182 (194) T 2atx_A 123 ------------------VPFLLIGTQIDLRDDPKTLARLNDMKEKPIC--VEQGQKLAKEIGACCYVECSALTQKGLKT 182 (194) T ss_dssp ------------------CCEEEEEECTTSTTCHHHHHHHTTTTCCCCC--HHHHHHHHHHHTCSCEEECCTTTCTTHHH T ss_pred ------------------CCEEEEECCCCCCCCHHHHHHHHHHHCCCCC--HHHHHHHHHHCCCCEEEEEEECCCCCHHH T ss_conf ------------------5379986264555430367776552025637--89999999971892278975048878889 Q ss_pred HH Q ss_conf 65 Q Fun_An_XP_0013 284 LI 285 (523) Q Consensus 284 Ll 285 (523) +. T Consensus 183 ~f 184 (194) T 2atx_A 183 VF 184 (194) T ss_dssp HH T ss_pred HH T ss_conf 99 No 45 >2dpx_A GTP-binding protein RAD; GTPase, small-G, RGK, signal transduction, diabetes; HET: GDP; 1.80A {Homo sapiens} Probab=97.88 E-value=0.00036 Score=49.52 Aligned_columns=154 Identities=20% Q ss_pred EEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHH Q ss_conf 47886477987321232331111245566312256567444433420223310006774551101678717887112320 Q Fun_An_XP_0013 48 NLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPL 127 (523) Q Consensus 48 nilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~L 127 (523) .|+|+|...+||++|+..+.+..... .+|....+--...++|=.. .++.+|=. .|...+..+ T Consensus 9 kI~viG~~~~GKTsli~~l~~~~~~~----------~~~~~~~~~~~~i~~~~~~-------~~l~i~D~-~g~~~~~~~ 70 (174) T 2dpx_A 9 KVLLLGAPGVGKSALARIFGGVEDGP----------EAEAAGHTYDRSIVVDGEE-------ASLMVYDI-WEQDGGRWL 70 (174) T ss_dssp EEEEECCTTSSHHHHHHHHHTCC-------------------CEEEEEEEETTEE-------EEEEEECC--------CC T ss_pred EEEEEECCCCCHHHHHHHHHCCCCCC----------CCCEEEEEEEEEEEECCEE-------EEEEEEEC-CCCCCCHHH T ss_conf 89998079987999999984563664----------1230476455423660401-------34777621-000100111 Q ss_pred HHHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 01105810120033433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 128 LKPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 128 Lk~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) .+..+..-. .++|+.|.++|+++ +.+.+|...+.++...- T Consensus 71 ~~~~~~~~d----~~i~v~d~~~~~s~-~~~~~~~~~i~~~~~~~----------------------------------- 110 (174) T 2dpx_A 71 PGHCMAMGD----AYVIVYSVTDKGSF-EKASELRVQLRRARQTD----------------------------------- 110 (174) T ss_dssp HHHHHTSCS----EEEEEEETTCHHHH-HHHHHHHHHHHHHC-------------------------------------- T ss_pred HHHHHHCCH----HHHHEECCCCCCCC-CCCCHHHHHHHHCCCCC----------------------------------- T ss_conf 111110100----00000002123420-10000123432101124----------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHH Q ss_conf 45321368887532678950799961875567888635885568999999999999871841255212332103456553 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIHS 287 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh~ 287 (523) .+|++||++|+| ..+.-....+-++.|+-+||+..|.||.+...+...+... T Consensus 111 -----------------~~piiiv~nK~D-----------l~~~~~v~~~e~~~~~~~~~~~~~~~Sak~~~~i~~~f~~ 162 (174) T 2dpx_A 111 -----------------DVPIILVGNKSD-----------LVRSREVSVDEGRACAVVFDCKFIETSAALHHNVQALFEG 162 (174) T ss_dssp -----------------CCCEEEEEECTT-----------CCTTCCSCHHHHHHHHHHHTSEEEECBTTTTBTHHHHHHH T ss_pred -----------------CEEEEEEHHCCC-----------HHHHCCCCHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHH T ss_conf -----------------202010011122-----------1231155278888899865971899861689788899999 No 46 >cd04122 Rab14 Rab14 subfamily. Rab14 GTPases are localized to biosynthetic compartments, including the rough ER, the Golgi complex, and the trans-Golgi network, and to endosomal compartments, including early endosomal vacuoles and associated vesicles. Rab14 is believed to function in both the biosynthetic and recycling pathways between the Golgi and endosomal compartments. Rab14 has also been identified on GLUT4 vesicles, and has been suggested to help regulate GLUT4 translocation. In addition, Rab14 is believed to play a role in the regulation of phagocytosis. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GT Probab=97.85 E-value=0.0013 Score=45.81 Aligned_columns=152 Identities=14% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+|+|..+.|||+|+..+...+-.. +... -+|..|....= +.++...++.+|=.+.-+-+ T Consensus 5 ivviGd~~VGKTsli~r~~~~~f~~----~~~~----------Ti~~~~~~k~i-~~~~~~v~l~i~Dt~G~e~~----- 64 (166) T cd04122 5 YIIIGDMGVGKSCLLHQFTEKKFMA----DCPH----------TIGVEFGTRII-EVNGQKIKLQIWDTAGQERF----- 64 (166) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCC----CCCC----------CCCCEEEEEEE-EECCEEEEEEEEECCCCHHH----- T ss_conf 9998269955899998876384364----4562----------10221467888-52890899998635886023----- Q ss_pred HHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 110581012003-3433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 129 KPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 129 k~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) ..+.+..++++ .++|+-|.+.+-+| +.+.+|+.-++.+... T Consensus 65 -~~~~~~~~~~a~~~ilvydit~~~Sf-~~i~~w~~~~~~~~~~------------------------------------ 106 (166) T cd04122 65 -RAVTRSYYRGAAGALMVYDITRRSTY-NHLSSWLTDARNLTNP------------------------------------ 106 (166) T ss_pred -HHHHHHHCCCCCEEEEEEECCCHHHH-HHHHHHHHHHHHCCCC------------------------------------ T ss_conf -45538642698759998207998789-9999999999740489------------------------------------ Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHH Q ss_conf 4532136888753267895079996187556788863588556899999999999987184125521233210345655 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIH 286 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh 286 (523) .+|+++|.+||| |+.++....|+ ...+|-++|+..|-||++...|...+-+ T Consensus 107 -----------------~~~iilVGNK~D----L~~~r~v~~~e-------~~~~a~~~~~~~~E~SAk~~~nV~e~F~ 157 (166) T cd04122 107 -----------------NTVIFLIGNKAD----LEAQRDVTYEE-------AKQFADENGLLFLECSAKTGENVEDAFL 157 (166) T ss_pred -----------------CCEEEEECCHHH----HHHHCCCCHHH-------HHHHHHHCCCEEEEEECCCCCCHHHHHH T ss_conf -----------------957999637254----44303541789-------9999996499199997158988789999 No 47 >e2atva1 c.37.1.8 (A:5-172) Ras-like estrogen-regulated growth inhibitor, RERG {Human (Homo sapiens) [TaxID:9606]} Probab=97.85 E-value=0.0015 Score=45.57 Aligned_columns=163 Identities=15% Q ss_pred EEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHH Q ss_conf 47886477987321232331111245566312256567444433420223310006774551101678717887112320 Q Fun_An_XP_0013 48 NLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPL 127 (523) Q Consensus 48 nilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~L 127 (523) .|+++|....||++||..+.+..... +... .++..|.-...-|... -.+.+|-. .+...+... T Consensus 4 KI~iiG~~~vGKSsli~~~~~~~~~~----~~~~----------t~~~~~~~~~~~~~~~--~~~~i~d~-~g~~~~~~~ 66 (168) T e2atva1 4 KLAIFGRAGVGKSALVVRFLTKRFIW----EYDP----------TLESTYRHQATIDDEV--VSMEILDT-AGQEDTIQR 66 (168) T ss_pred EEEEEECCCCCHHHHHHHHHCCCCCC----CCCC----------CEEEEEEEEEEECCEE--EEEEEEEE-CCCHHHHHH T ss_conf 89998079987999999986381167----6256----------2366678999756907--99999862-063046666 Q ss_pred HHHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 01105810120033433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 128 LKPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 128 Lk~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) ..+.-.+. .++|+.|.+.|.++-. +..|...++.....- T Consensus 67 ~~~~~~~d-----~~ilv~d~~~~~S~~~-~~~~~~~i~~~~~~~----------------------------------- 105 (168) T e2atva1 67 EGHMRWGE-----GFVLVYDITDRGSFEE-VLPLKNILDEIKKPK----------------------------------- 105 (168) T ss_pred HHHHCCCC-----EEEEEEEECCCCCHHH-HHHHHHHHHHHCCCC----------------------------------- T ss_conf 65411782-----7999986448565668-889999988631899----------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCC-CHHHHHH Q ss_conf 453213688875326789507999618755678886358855689999999999998718412552123321-0345655 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLAN-SLQSLIH 286 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~-nl~~Llh 286 (523) .+|++||++|+| |+.+.....++. +.+|-++++..|.||.+... |...+.+ T Consensus 106 -----------------~~piiivgnK~D----l~~~~~i~~~e~-------~~~~~~~~~~~~e~Sa~~g~gnv~e~f~ 157 (168) T e2atva1 106 -----------------NVTLILVGNKAD----LDHSRQVSTEEG-------EKLATELACAFYECSACTGEGNITEIFY 157 (168) T ss_pred -----------------CCEEEEEEECCC----CCCCCCCCHHHH-------HHHHHHCCCCEEEEEECCCCCCHHHHHH T ss_conf -----------------978999971356----443466798999-------9999964994999972259836789999 Q ss_pred HHCCCCCCCCCC Q ss_conf 322532246675 Q Fun_An_XP_0013 287 SSLGIHSLLKRQ 298 (523) Q Consensus 287 ~~lgih~ll~~~ 298 (523) .. +..+++|. T Consensus 158 ~l--~~~i~~~~ 167 (168) T e2atva1 158 EL--CREVRRRR 167 (168) T ss_pred HH--HHHHHHCC T ss_conf 99--99998605 No 48 >cd04101 RabL4 RabL4 (Rab-like4) subfamily. RabL4s are novel proteins that have high sequence similarity with Rab family members, but display features that are distinct from Rabs, and have been termed Rab-like. As in other Rab-like proteins, RabL4 lacks a prenylation site at the C-terminus. The specific function of RabL4 remains unknown. Probab=97.85 E-value=0.0018 Score=44.90 Aligned_columns=153 Identities=14% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|..+-||++|+..+......-...-...- +.+|....+.= +.+++ ..+.+|=. .|...+..+. T Consensus 3 vv~iGd~~VGKTsli~~~~~~~~~f~~~y~~T~----------~~~~~~~~~~i-~~~~~-~~l~i~Dt-aGqe~~~~~~ 69 (164) T cd04101 3 CAVVGDPAVGKTAFVQMFHSNGAVFPKNYLMTT----------GCDFVVKEVPV-DTDNT-VELFIFDS-AGQELYSDMV 69 (164) T ss_pred EEEEECCCCCHHHHHHHHHHCCCEECCCCCCCE----------EEEEEEEEEEE-CCCCE-EEEEEEEC-CCCHHHHHHH T ss_conf 899807982189888877616844166654311----------24567999997-79967-99999603-8722467887 Q ss_pred HHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC Q ss_conf 11058101200334333000031368999999999999998506958889999999998622688767777767777664 Q Fun_An_XP_0013 129 KPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSSA 208 (523) Q Consensus 129 k~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s~ 208 (523) +..+.--.. ++|+-|.+++.+| +.+.+|+.-++.+-. T Consensus 70 ~~~~~~a~~----~ilvydit~~~Sf-~~i~~w~~~i~~~~~-------------------------------------- 106 (164) T cd04101 70 SNYWESPSV----FILVYDVSNKASF-ENCSRWVNKVRTASK-------------------------------------- 106 (164) T ss_pred HHHCCCCCE----EEEEEECCCHHHH-HHHHHHHHHHHHHCC-------------------------------------- T ss_conf 874249976----9999417997689-999999999998449-------------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHH Q ss_conf 5321368887532678950799961875567888635885568999999999999871841255212332103456 Q Fun_An_XP_0013 209 GPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSL 284 (523) Q Consensus 209 ~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~L 284 (523) .+|+++|.+|+| |+..+--.+++ .+.+|-.+|+..|.||++...|...+ T Consensus 107 ----------------~~p~ilVGNK~D----L~~~r~V~~~~-------~~~~a~~~~~~~~e~SAktg~nV~e~ 155 (164) T cd04101 107 ----------------HMPGVLVGNKMD----LADKAEVTDAQ-------AQAFAQANQLKFFKTSALRGVGYEEP 155 (164) T ss_pred ----------------CCEEEEEECCCC----CCCCCCCCHHH-------HHHHHHHCCCCEEEEECCCCCCHHHH T ss_conf ----------------973999821434----00116789899-------99999963994999971689887899 No 49 >2atv_A RERG, RAS-like estrogen-regulated growth inhibitor; GDP/GTP binding, GTP hydrolysis, structural genomics, structural genomics consortium, SGC; HET: GDP; 1.90A {Homo sapiens} SCOP: c.37.1.8 Probab=97.84 E-value=0.0029 Score=43.60 Aligned_columns=156 Identities=15% Q ss_pred EEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHH Q ss_conf 47886477987321232331111245566312256567444433420223310006774551101678717887112320 Q Fun_An_XP_0013 48 NLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPL 127 (523) Q Consensus 48 nilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~L 127 (523) .|+|+|..+.||++|+..+....-.. +... -+|..|.....-|..+ -++.+|-. .+...+..+ T Consensus 30 KI~viG~~~vGKTsLi~~~~~~~~~~----~~~~----------Ti~~~~~~~~~~~~~~--~~l~i~d~-~g~~~~~~~ 92 (196) T 2atv_A 30 KLAIFGRAGVGKSALVVRFLTKRFIW----EYDP----------TLESTYRHQATIDDEV--VSMEILDT-AGQEDTIQR 92 (196) T ss_dssp EEEEECCTTSSHHHHHHHHHHSCCCS----CCCT----------TCCEEEEEEEEETTEE--EEEEEEEC-CCCCCCHHH T ss_pred EEEEEECCCCCHHHHHHHHHCCCCCC----CCCC----------CEEEEEEEEEEECCEE--EEEEEECC-CCCCHHHHH T ss_conf 79998079977899999986381576----5453----------1003688988861568--88877404-443201220 Q ss_pred HHHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 01105810120033433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 128 LKPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 128 Lk~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) ..+.-.+. .+|++.|.+.|.++-. +..|...++..-..- T Consensus 93 ~~~~~~~d-----~~ilvfD~~~~~S~~~-~~~~~~~~~~~~~~~----------------------------------- 131 (196) T 2atv_A 93 EGHMRWGE-----GFVLVYDITDRGSFEE-VLPLKNILDEIKKPK----------------------------------- 131 (196) T ss_dssp HHHHHHCS-----EEEEEEETTCHHHHHT-HHHHHHHHHHHHTTS----------------------------------- T ss_pred HHHCCCCC-----EEEEEEEECCCCCHHH-HHHHHHCCCCCCCCC----------------------------------- T ss_conf 12003560-----4789998504546224-555531011223678----------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCC-CHHHHHH Q ss_conf 453213688875326789507999618755678886358855689999999999998718412552123321-0345655 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLAN-SLQSLIH 286 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~-nl~~Llh 286 (523) .+|+++|++|+| |++++.-..++ ++.||=.+|+..|.||++... |...+.. T Consensus 132 -----------------~~piilVgnK~D----l~~~r~i~~~e-------~~~~a~~~~~~~~e~Sak~g~~nV~e~f~ 183 (196) T 2atv_A 132 -----------------NVTLILVGNKAD----LDHSRQVSTEE-------GEKLATELACAFYECSACTGEGNITEIFY 183 (196) T ss_dssp -----------------CCCEEEEEECGG----GGGGCCSCHHH-------HHHHHHHHTSEEEECCTTTCTTCHHHHHH T ss_pred -----------------CCEEEEEECCCC----CCHHCCCCHHH-------HHHHHHHCCCCEEEEEECCCCCCHHHHHH T ss_conf -----------------861899952534----10011677889-------99999964994899972058824788999 Q ss_pred HHC Q ss_conf 322 Q Fun_An_XP_0013 287 SSL 289 (523) Q Consensus 287 ~~l 289 (523) ..+ T Consensus 184 ~l~ 186 (196) T 2atv_A 184 ELC 186 (196) T ss_dssp HHH T ss_pred HHH T ss_conf 999 No 50 >cd01866 Rab2 Rab2 subfamily. Rab2 is localized on cis-Golgi membranes and interacts with Golgi matrix proteins. Rab2 is also implicated in the maturation of vesicular tubular clusters (VTCs), which are microtubule-associated intermediates in transport between the ER and Golgi apparatus. In plants, Rab2 regulates vesicle trafficking between the ER and the Golgi bodies and is important to pollen tube growth. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site at the C-terminus, with sequence motifs CC, CXC, or CCX. Lipid binding is essential for membrane attachment, a key featur Probab=97.82 E-value=0.0021 Score=44.54 Aligned_columns=152 Identities=17% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|..+.||++|+..+...+-.. .+.-.- |.+|....|.-.+.. .++.+|=.+..+-+ T Consensus 7 ivliGd~~VGKTsli~r~~~~~f~~----~~~~Ti--------~~~~~~k~i~~~~~~---v~l~iwDt~G~e~~----- 66 (168) T cd01866 7 YIIIGDTGVGKSCLLLQFTDKRFQP----VHDLTI--------GVEFGARMITIDGKQ---IKLQIWDTAGQESF----- 66 (168) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCC----CCCCCE--------EEEEEEEECCCCCCE---EEEEEEECCCCCCH----- T ss_conf 9998169843899999985482575----445300--------000012321467842---89998753888411----- Q ss_pred HHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 110581012003-3433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 129 KPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 129 k~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) ..+.+..++++ .++|+-|.+++-+| +.|..|+..++.+... T Consensus 67 -~~l~~~~~~~a~~~iivfdvt~~~Sf-~~i~~w~~~~~~~~~~------------------------------------ 108 (168) T cd01866 67 -RSITRSYYRGAAGALLVYDITRRETF-NHLTSWLEDARQHSNS------------------------------------ 108 (168) T ss_pred -HHHHHHHCCCCCEEEEEEECCCHHHH-HHHHHHHHHHHHHCCC------------------------------------ T ss_conf -24536534799779999766997789-9999999999973699------------------------------------ Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHH Q ss_conf 4532136888753267895079996187556788863588556899999999999987184125521233210345655 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIH 286 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh 286 (523) .+|+++|-+|+| |+.++....++ .+.+|-++|+..|-||++...|...+-+ T Consensus 109 -----------------~~piilVGnK~D----L~~~r~v~~~e-------~~~~a~~~~~~~~E~SAkt~~nV~~~F~ 159 (168) T cd01866 109 -----------------NMTIMLIGNKCD----LESRREVSYEE-------GEAFAKEHGLIFMETSAKTASNVEEAFI 159 (168) T ss_pred -----------------CCEEEEEECCHH----HHHHCCCCHHH-------HHHHHHHCCCEEEEEECCCCCCHHHHHH T ss_conf -----------------968999833201----23304776889-------9999996598499986157988789999 No 51 >e2f7sa1 c.37.1.8 (A:5-190) Rab27b {Human (Homo sapiens) [TaxID:9606]} SCOP: u2f7sb_ Probab=97.81 E-value=0.00072 Score=47.55 Aligned_columns=168 Identities=18% Q ss_pred EEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHH Q ss_conf 47886477987321232331111245566312256567444433420223310006774551101678717887112320 Q Fun_An_XP_0013 48 NLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPL 127 (523) Q Consensus 48 nilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~L 127 (523) .|+++|....||+||+..+.+.................. .+.+.-........+.....++.|-. .+...+..+ T Consensus 7 ki~ivG~~~vGKSsLi~~l~~~~~~~~~~~t~~~~~~~~-----~~~~~~~~~~~~~~~~~~~~~~~~d~-~~~~~~~~~ 80 (186) T e2f7sa1 7 KLLALGDSGVGKTTFLYRYTDNKFNPKFITTVGIDFREK-----RVVYNAQGPNGSSGKAFKVHLQLWDT-AGQERFRSL 80 (186) T ss_pred EEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEE-----EEEECCCCCEEEECCCEEEEEEEEEC-CCHHHHHHH T ss_conf 999981799879999999865811665145430135799-----99986755200001440589998762-102332101 Q ss_pred HHHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 01105810120033433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 128 LKPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 128 Lk~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) .+..+..-. .++++.|.++++++-+ +..|+.-++.....- T Consensus 81 ~~~~~~~~d----~ii~v~d~~~~~s~~~-~~~~~~~i~~~~~~~----------------------------------- 120 (186) T e2f7sa1 81 TTAFFRDAM----GFLLMFDLTSQQSFLN-VRNWMSQLQANAYCE----------------------------------- 120 (186) T ss_pred HHHHHCCCC----EEEEECCCCCCCCHHH-HHHHHHHHHHHCCCC----------------------------------- T ss_conf 022200435----4898303456555678-989999999850679----------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHH Q ss_conf 45321368887532678950799961875567888635885568999999999999871841255212332103456553 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIHS 287 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh~ 287 (523) .+|++||++|+| ..++.....+.++.|+-++|...|-||.+...+...+... T Consensus 121 -----------------~~piiiv~nK~D-----------l~~~~~v~~~~~~~~~~~~~~~~~~~Sa~~g~gi~e~f~~ 172 (186) T e2f7sa1 121 -----------------NPDIVLIGNKAD-----------LPDQREVNERQARELADKYGIPYFETSAATGQNVEKAVET 172 (186) T ss_pred -----------------CCEEEEEECCCC-----------CCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHH T ss_conf -----------------964899740544-----------2212477989999999964993999962689688899999 Q ss_pred HC Q ss_conf 22 Q Fun_An_XP_0013 288 SL 289 (523) Q Consensus 288 ~l 289 (523) .+ T Consensus 173 l~ 174 (186) T e2f7sa1 173 LL 174 (186) T ss_pred HH T ss_conf 99 No 52 >1m7b_A RND3/RHOE small GTP-binding protein; small GTPase; HET: GTP; 2.00A {Homo sapiens} SCOP: c.37.1.8 Probab=97.80 E-value=0.00076 Score=47.42 Aligned_columns=171 Identities=16% Q ss_pred HCCCCCEEEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCC Q ss_conf 04884204788647798732123233111124556631225656744443342022331000677455110167871788 Q Fun_An_XP_0013 41 GKRLPEKNLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEP 120 (523) Q Consensus 41 ~~rlpsKnilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~ 120 (523) +++--...|+|+|..+.||++|+..+......... .|-+...|-..+ +.++....+.+|=. .| T Consensus 2 ~~~~~r~KI~iiG~~~vGKSsLi~~~~~~~~~~~~--------~~t~~~~~~~~~--------~~~~~~~~l~i~D~-~g 64 (184) T 1m7b_A 2 SNQNVKCKIVVVGDSQCGKTALLHVFAKDCFPENY--------VPTVFENYTASF--------EIDTQRIELSLWDT-SG 64 (184) T ss_dssp ----CEEEEEEEESTTSSHHHHHHHHHHSCCCSSC--------CCCSEEEEEEEE--------ECSSCEEEEEEEEE-CC T ss_pred CCCCEEEEEEEEECCCCCHHHHHHHHHCCCCCCCC--------CCEEEEEEEEEE--------EECCEEEEEEECCC-CC T ss_conf 88542699999817998789999998638436663--------543777565532--------20653477642145-44 Q ss_pred CHHHHHHHHHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCC Q ss_conf 71123200110581012003343330000313689999999999999985069588899999999986226887677777 Q Fun_An_XP_0013 121 SLSFAPLLKPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGG 200 (523) Q Consensus 121 d~~~~~LLk~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~ 200 (523) ...+..+.+..+. .-..++++.|.+.+.++-+-++.|...++.+.. T Consensus 65 ~~~~~~~~~~~~~----~~~~ii~v~d~~~~~sf~~~~~~~~~~~~~~~~------------------------------ 110 (184) T 1m7b_A 65 SPYYDNVRPLSYP----DSDAVLICFDISRPETLDSVLKKWKGEIQEFCP------------------------------ 110 (184) T ss_dssp SGGGTTTGGGGCT----TCSEEEEEEETTCHHHHHHHHHTHHHHHHHHCT------------------------------ T ss_pred CCCCCCCCHHHHC----CCEEEEEEEECCCHHHHHHHHHHHHHHHHHHCC------------------------------ T ss_conf 4333100001101----212466664067165688888877888876179------------------------------ Q ss_pred CCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHH-HHHHHHHHHHHCCEEEE-ECCCCC Q ss_conf 6777766453213688875326789507999618755678886358855689999-99999999871841255-212332 Q Fun_An_XP_0013 201 AQGFTSSAGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFI-LQFMRTLLLKHGASLIY-TTPFLA 278 (523) Q Consensus 201 ~~~~~~s~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfI-qQ~lRt~cLqYGAsLiY-TS~~~~ 278 (523) .+|+++|++|+|.............++...| .+-...+|=+.|+-.++ ||.+.. T Consensus 111 ------------------------~~piilvgnK~D~~~~~~~~~~~~~~~~~~i~~~~~~~~~~~~~~~~~~E~Sak~~ 166 (184) T 1m7b_A 111 ------------------------NTKMLLVGCKSDLRTDVSTLVELSNHRQTPVSYDQGANMAKQIGAATYIECSALQS 166 (184) T ss_dssp ------------------------TCEEEEEEECGGGGGCHHHHHHHHTTTCCCCCHHHHHHHHHHHTCSEEEECBTTTB T ss_pred ------------------------CCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEEEECCC T ss_conf ------------------------94189986254754320367887752033558899999999718953899751468 Q ss_pred CC-HHHHHH Q ss_conf 10-345655 Q Fun_An_XP_0013 279 NS-LQSLIH 286 (523) Q Consensus 279 ~n-l~~Llh 286 (523) .| ...+.+ T Consensus 167 ~n~v~e~f~ 175 (184) T 1m7b_A 167 ENSVRDIFH 175 (184) T ss_dssp HHHHHHHHH T ss_pred CCHHHHHHH T ss_conf 724899999 No 53 >d1ek0a_ c.37.1.8 (A:) Ypt51 {Baker's yeast (Saccharomyces cerevisiae)} Probab=97.80 E-value=0.0035 Score=43.09 Aligned_columns=155 Identities=16% Q ss_pred EEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHH Q ss_conf 47886477987321232331111245566312256567444433420223310006774551101678717887112320 Q Fun_An_XP_0013 48 NLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPL 127 (523) Q Consensus 48 nilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~L 127 (523) .|+++|..+.||++|+..+.+..... +...+- +..|....+.-.+.. .++.+|-. .|...+..+ T Consensus 5 Ki~ivG~~~vGKTsli~~l~~~~~~~----~~~~t~--------~~~~~~~~i~~~~~~---~~~~i~D~-~g~~~~~~~ 68 (170) T d1ek0a_ 5 KLVLLGEAAVGKSSIVLRFVSNDFAE----NKEPTI--------GAAFLTQRVTINEHT---VKFEIWDT-AGQERFASL 68 (170) T ss_dssp EEEEECSTTSSHHHHHHHHHHSCCCT----TCCCCS--------SEEEEEEEEEETTEE---EEEEEEEE-CCSGGGGGG T ss_pred EEEEEECCCCCHHHHHHHHHCCCCCC----CCCCEE--------EEEEEEEEEEECCEE---EEEEEECC-CCCHHHHHH T ss_conf 89998079987999999986483357----635315--------533567789998968---99987226-682245555 Q ss_pred HHHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 01105810120033433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 128 LKPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 128 Lk~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) .+..+..-.. ++++.|.+.|.++ +++..|+..++..... T Consensus 69 ~~~~~~~~d~----~i~v~d~~~~~s~-~~~~~~~~~i~~~~~~------------------------------------ 107 (170) T d1ek0a_ 69 APXYYRNAQA----ALVVYDVTKPQSF-IKARHWVKELHEQASK------------------------------------ 107 (170) T ss_dssp HHHHHTTCSE----EEEEEETTCHHHH-HHHHHHHHHHHHHSCT------------------------------------ T ss_pred HHHHHCCCCC----EEEEEEECCCHHH-HHHHHHHHHHHHHHCC------------------------------------ T ss_conf 2544035784----1899974161236-7899999999864215------------------------------------ Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHH Q ss_conf 45321368887532678950799961875567888635885568999999999999871841255212332103456 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSL 284 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~L 284 (523) ..|+++|.+|+|..+...+..-- ++-++.++-++++..+.+|.+...+++.+ T Consensus 108 -----------------~~~~iiv~nK~D~~~~~~~~~i~--------~~~~~~~~~~~~~~~~e~Sa~~~~gi~e~ 159 (170) T d1ek0a_ 108 -----------------DIIIALVGNKIDXLQEGGERKVA--------REEGEKLAEEKGLLFFETSAKTGENVNDV 159 (170) T ss_dssp -----------------TCEEEEEEECGGGGGSSCCCCSC--------HHHHHHHHHHHTCEEEECCTTTCTTHHHH T ss_pred -----------------CCCEEEEECCCCCCCCCCCCCCC--------HHHHHHHHHHCCCEEEEEECCCCCCHHHH T ss_conf -----------------87279997175521115654217--------78999999955984999862689788899 No 54 >d1wmsa_ c.37.1.8 (A:) Rab9a {Human (Homo sapiens)} SCOP: d1s8fb_ d1wmsb_ d1s8fa_ u1yzla1 Probab=97.79 E-value=0.004 Score=42.70 Aligned_columns=158 Identities=15% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|..+.||+||+..+.... ....-..++ +..|....+.-.... ..+.+|-. .+.-.+..+. T Consensus 9 i~iiG~~~vGKTsLi~~l~~~~-------~~~~~~~t~-----~~~~~~~~~~~~~~~---~~l~i~d~-~~~~~~~~~~ 72 (174) T d1wmsa_ 9 VILLGDGGVGKSSLMNRYVTNK-------FDTQLFHTI-----GVEFLNKDLEVDGHF---VTMQIWDT-AGQERFRSLR 72 (174) T ss_dssp EEEECCTTSSHHHHHHHHHHSC-------CCC----CC-----SEEEEEEEEEETTEE---EEEEEEEC-CCCGGGHHHH T ss_pred EEEEECCCCCHHHHHHHHHCCC-------CCCCCCCEE-----EECCEEEEEEECCEE---EEEEEEEC-CCCHHHHHHH T ss_conf 9998179987899999986481-------356633214-----301047899988938---89987202-4640234544 Q ss_pred HHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC Q ss_conf 11058101200334333000031368999999999999998506958889999999998622688767777767777664 Q Fun_An_XP_0013 129 KPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSSA 208 (523) Q Consensus 129 k~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s~ 208 (523) +..+..-. .++++.|.+.+.++-. +.+|...++.+......+ T Consensus 73 ~~~~~~~d----~ii~v~D~s~~~s~~~-i~~~~~~i~~~~~~~~~~--------------------------------- 114 (174) T d1wmsa_ 73 TPFYRGSD----CCLLTFSVDDSQSFQN-LSNWKKEFIYYADVKEPE--------------------------------- 114 (174) T ss_dssp GGGGTTCS----EEEEEEETTCHHHHHT-HHHHHHHHHHHHTCSCTT--------------------------------- T ss_pred HHHHCCCC----EEEEEEECCCHHHHHH-HHHHHHHHHHHCCCCCCC--------------------------------- T ss_conf 44205772----7999985288679998-855678887640456778--------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEE-ECCCCCCCHHHHHHH Q ss_conf 5321368887532678950799961875567888635885568999999999999871841255-212332103456553 Q Fun_An_XP_0013 209 GPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIY-TTPFLANSLQSLIHS 287 (523) Q Consensus 209 ~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiY-TS~~~~~nl~~Llh~ 287 (523) ++|+++|++|+| |..+.-..+| ++.+.-+++.-.+| ||.+...+.+.+... T Consensus 115 ----------------~~piilv~nK~D----l~~~~v~~~e--------~~~~~~~~~~~~~~e~Sak~g~~v~e~f~~ 166 (174) T d1wmsa_ 115 ----------------SFPFVILGNKID----ISERQVSTEE--------AQAWCRDNGDYPYFETSAKDATNVAAAFEE 166 (174) T ss_dssp ----------------TSCEEEEEECTT----CSSCSSCHHH--------HHHHHHHTTCCCEEECCTTTCTTHHHHHHH T ss_pred ----------------CCCEEEEECCCC----CCCCCCCHHH--------HHHHHHHCCCCCEEEEECCCCCCHHHHHHH T ss_conf ----------------861899950558----2213588899--------999999707970899860589888899999 Q ss_pred H Q ss_conf 2 Q Fun_An_XP_0013 288 S 288 (523) Q Consensus 288 ~ 288 (523) . T Consensus 167 l 167 (174) T d1wmsa_ 167 A 167 (174) T ss_dssp H T ss_pred H T ss_conf 9 No 55 >2oil_A CATX-8, RAS-related protein RAB-25; G-protein, GDP, structural genomics, structural genomics consortium, SGC; HET: GDP; 2.30A {Homo sapiens} Probab=97.77 E-value=0.0027 Score=43.85 Aligned_columns=152 Identities=12% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|..+.||+||+..+.+..... +... -.++.+....- ..++..-++.+|-. .+...+..+. T Consensus 28 I~iiG~~~vGKSSli~~l~~~~~~~----~~~~----------t~~~~~~~~~~-~~~~~~~~l~i~d~-~g~~~~~~~~ 91 (193) T 2oil_A 28 VVLIGESGVGKTNLLSRFTRNEFSH----DSRT----------TIGVEFSTRTV-MLGTAAVKAQIWDT-AGLERYRAIT 91 (193) T ss_dssp EEEESSTTSSHHHHHHHHHHSCCCS----SCCC----------CSSEEEEEEEE-EETTEEEEEEEEEE-SCCCTTCTTH T ss_pred EEEEECCCCCHHHHHHHHHCCCCCC----CCCC----------CEEEEEEEEEE-EECCEEEEEEEECC-CCCHHHCCCH T ss_conf 9998079987999999986581157----6356----------14666777788-76565666676146-6700110000 Q ss_pred HHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC Q ss_conf 11058101200334333000031368999999999999998506958889999999998622688767777767777664 Q Fun_An_XP_0013 129 KPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSSA 208 (523) Q Consensus 129 k~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s~ 208 (523) +..+..-. .++++.|.+++.++ +.+.+|+.-++.+... T Consensus 92 ~~~~~~~~----~~i~v~d~~~~~s~-~~~~~~~~~i~~~~~~------------------------------------- 129 (193) T 2oil_A 92 SAYYRGAV----GALLVFDLTKHQTY-AVVERWLKELYDHAEA------------------------------------- 129 (193) T ss_dssp HHHHTTCC----EEEEEEETTCHHHH-HTHHHHHHHHHTTSCT------------------------------------- T ss_pred HCCCCCCE----EEEEEEEECCCCHH-HHHHHHHHHHHHCCCC------------------------------------- T ss_conf 02256752----79999750340000-0111100122100356------------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHH Q ss_conf 53213688875326789507999618755678886358855689999999999998718412552123321034565 Q Fun_An_XP_0013 209 GPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLI 285 (523) Q Consensus 209 ~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Ll 285 (523) .+|+++|++|+| |+++..-.. +.++.+|-.++...|.+|.+...++..|. T Consensus 130 ----------------~~piilv~nK~D----l~~~~~v~~-------~~~~~~~~~~~~~~~~~Sak~~~~I~elf 179 (193) T 2oil_A 130 ----------------TIVVMLVGNKSD----LSQAREVPT-------EEARMFAENNGLLFLETSALDSTNVELAF 179 (193) T ss_dssp ----------------TCEEEEEEECGG----GGGGCCSCH-------HHHHHHHHHTTCEEEEECTTTCTTHHHHH T ss_pred ----------------CEEEEEEECCHH----HHHHHCCHH-------HHHHHHHHHCCCEEEEEECCCCCCHHHHH T ss_conf ----------------134433213202----233311136-------77789998659729998626897888999 No 56 >1z2a_A RAS-related protein RAB-23; RAB GTPase, vesicular trafficking, protein transport; HET: GDP; 1.90A {Mus musculus} SCOP: c.37.1.8 Probab=97.76 E-value=0.0037 Score=42.93 Aligned_columns=162 Identities=17% Q ss_pred EEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHH Q ss_conf 47886477987321232331111245566312256567444433420223310006774551101678717887112320 Q Fun_An_XP_0013 48 NLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPL 127 (523) Q Consensus 48 nilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~L 127 (523) .|+++|..+.||++|+..+....... +....- +..|....+...+.. ..+..|-. .+...+..+ T Consensus 7 Ki~ivG~~~vGKSsll~~~~~~~~~~----~~~~t~--------~~~~~~~~~~~~~~~---~~~~~~d~-~g~~~~~~~ 70 (168) T 1z2a_A 7 KMVVVGNGAVGKSSMIQRYCKGIFTK----DYKKTI--------GVDFLERQIQVNDED---VRLMLWDT-AGQEEFDAI 70 (168) T ss_dssp EEEEECSTTSSHHHHHHHHHHCCCCC----CSSCCC--------SSSEEEEEEEETTEE---EEEEEECC-TTGGGTTCC T ss_pred EEEEECCCCCCHHHHHHHHHCCCCCC----CCCCCC--------CCCCCCEECCCCCCE---EEEEEECC-CCCCCCCHH T ss_conf 89998189977899999986381465----422101--------221000010358815---89864115-775310010 Q ss_pred HHHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 01105810120033433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 128 LKPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 128 Lk~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) .+..+. .-..++|+.|.++|.++-+ +.+|+.-++.+ T Consensus 71 ~~~~~~----~~~~~i~v~d~~~~~s~~~-~~~~~~~i~~~--------------------------------------- 106 (168) T 1z2a_A 71 TKAYYR----GAQACVLVFSTTDRESFEA-ISSWREKVVAE--------------------------------------- 106 (168) T ss_dssp CHHHHT----TCCEEEEEEETTCHHHHHT-HHHHHHHHHHH--------------------------------------- T ss_pred HHHHHH----CCHHHHHHHHHHHHHHHHH-HHHHHHHHHHC--------------------------------------- T ss_conf 134431----1011011111001123333-22100001210--------------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHH Q ss_conf 45321368887532678950799961875567888635885568999999999999871841255212332103456553 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIHS 287 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh~ 287 (523) .-.+|+++|++|+|. .++.....+ .++.|+-++|+..|.+|.+...+...|... T Consensus 107 ---------------~~~~~iilvgnK~Dl----~~~~~v~~~-------~~~~~a~~~~~~~~e~Sa~~~~~i~~l~~~ 160 (168) T 1z2a_A 107 ---------------VGDIPTALVQNKIDL----LDDSCIKNE-------EAEGLAKRLKLRFYRTSVKEDLNVSEVFKY 160 (168) T ss_dssp ---------------HCSCCEEEEEECGGG----GGGCSSCHH-------HHHHHHHHHTCEEEECBTTTTBSSHHHHHH T ss_pred ---------------CCCCEEEEEECCCCH----HHHHHHHHH-------HHHHHHHHCCCCEEEEECCCCCCHHHHHHH T ss_conf ---------------688238997313571----232100478-------999999965991899861589788899999 Q ss_pred HCCCCCCCCC Q ss_conf 2253224667 Q Fun_An_XP_0013 288 SLGIHSLLKR 297 (523) Q Consensus 288 ~lgih~ll~~ 297 (523) . +..++.+ T Consensus 161 l--~~~~l~k 168 (168) T 1z2a_A 161 L--AEKHLQK 168 (168) T ss_dssp H--HHHHHC- T ss_pred H--HHHHHHC T ss_conf 9--9999719 No 57 >cd00877 Ran Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases. Ran GTPase is involved in diverse biological functions, such as nuclear transport, spindle formation during mitosis, DNA replication, and cell division. Among the Ras superfamily, Ran is a unique small G protein. It does not have a lipid modification motif at the C-terminus to bind to the membrane, which is often observed within the Ras superfamily. Ran may therefore interact with a wide range of proteins in various intracellular locations. Like other GTPases, Ran exists in GTP- and GDP-bound conformations that interact differently with effectors. Conversion between these forms and the assembly or disassembly of effector complexes requires the interaction of regulator proteins. The intrinsic GTPase activity of Ran is very low, but it is greatly stimulated by a GTPase-activating protein (RanGAP1) located in the cytoplasm. By contrast, RCC1, a guanine nucleotide exchange factor that generates RanGTP, is Probab=97.76 E-value=0.0028 Score=43.69 Aligned_columns=159 Identities=20% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|+.+.||++|+..+....-.. .+..-- |..+....+...+.. .++.+|=. .|...| T Consensus 3 IvliGd~~VGKTsli~r~~~~~F~~----~y~~Ti--------g~~~~~~~~~~~~~~---i~l~iwDt-aG~e~f---- 62 (166) T cd00877 3 LVLVGDGGTGKTTFVKRHLTGEFEK----KYVATL--------GVEVHPLDFHTNRGK---IRFNVWDT-AGQEKF---- 62 (166) T ss_pred EEEEECCCCCHHHHHHHHHCCEECC----CCCCEE--------EEEEEEEEEEECCCE---EEEEEEEC-CCCCCC---- T ss_conf 8998269844899988876381166----645346--------448889999987947---99998845-785213---- Q ss_pred HHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 110581012003-3433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 129 KPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 129 k~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) -.+.+..++++ .+|++-|.+.+++|-. +..|+.-++++.. T Consensus 63 -~~l~~~y~~~a~~~ilvfDit~~~Sf~~-i~~w~~~i~~~~~------------------------------------- 103 (166) T cd00877 63 -GGLRDGYYIGGQCAIIMFDVTSRVTYKN-VPNWHRDLVRVCG------------------------------------- 103 (166) T ss_pred -CCCCCCCCCCCCEEEEEEECCCHHHHHH-HHHHHHHHHHHCC------------------------------------- T ss_conf -5455120002675899986699789898-9889999986459------------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCH----HH Q ss_conf 45321368887532678950799961875567888635885568999999999999871841255212332103----45 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSL----QS 283 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl----~~ 283 (523) .+|+++|.+|+| |+......++. .++.++|+..|-||++...|. +. T Consensus 104 -----------------~ipivlVGNK~D----l~~~~~~~~~~---------~~~~~~~~~~~EtSAk~g~NV~e~F~~ 153 (166) T cd00877 104 -----------------NIPIVLCGNKVD----IKDRKVKAKQI---------TFHRKKNLQYYEISAKSNYNFEKPFLW 153 (166) T ss_pred -----------------CCCEEEEECCCC----CCCCCCCHHHH---------HHHHHCCCCEEEEECCCCCCHHHHHHH T ss_conf -----------------965899932677----32011248999---------999957994999970489898899999 Q ss_pred HHHHHCCCCCCCC Q ss_conf 6553225322466 Q Fun_An_XP_0013 284 LIHSSLGIHSLLK 296 (523) Q Consensus 284 Llh~~lgih~ll~ 296 (523) |+.+.|+--.|-+ T Consensus 154 la~~il~~~n~~~ 166 (166) T cd00877 154 LARKLLGNPNLEF 166 (166) T ss_pred HHHHHHCCCCCCC T ss_conf 9999853789789 No 58 >d1c1ya_ c.37.1.8 (A:) Rap1A {Human (Homo sapiens)} SCOP: d1guaa_ Probab=97.75 E-value=0.0053 Score=41.96 Aligned_columns=157 Identities=17% Q ss_pred EEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHH Q ss_conf 47886477987321232331111245566312256567444433420223310006774551101678717887112320 Q Fun_An_XP_0013 48 NLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPL 127 (523) Q Consensus 48 nilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~L 127 (523) .|+|+|..+.||+||+..+...+... .... -.+-.|.-...-+... ..+.+|-. .|...+..+ T Consensus 5 kI~viG~~~vGKTsLi~~~~~~~~~~----~~~~----------t~~~~~~~~~~~~~~~--~~~~~~D~-~g~~~~~~~ 67 (167) T d1c1ya_ 5 KLVVLGSGGVGKSALTVQFVQGIFVE----KYDP----------TIEDSYRKQVEVDCQQ--CMLEILDT-AGTEQFTAM 67 (167) T ss_dssp EEEEECSTTSSHHHHHHHHHHCCCCC----SCCC----------CSEEEEEEEEESSSCE--EEEEEEEE-CSSCSSTTH T ss_pred EEEEEECCCCCHHHHHHHHHCCCCCC----CCCC----------CCCEEEEEEEEECCEE--EEEEEEEC-CCCCCHHHH T ss_conf 89998079987899999986282166----5466----------3220368999873613--56788723-786411355 Q ss_pred HHHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 01105810120033433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 128 LKPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 128 Lk~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) .+.....-. .|+++.|.+.+++| +.+.+|..-+..+...- T Consensus 68 ~~~~~~~~~----~vilv~D~~~~~s~-~~~~~~~~~~~~~~~~~----------------------------------- 107 (167) T d1c1ya_ 68 RDLYMKNGQ----GFALVYSITAQSTF-NDLQDLREQILRVKDTE----------------------------------- 107 (167) T ss_dssp HHHHHHHCS----EEEEEEETTCHHHH-HTHHHHHHHHHHHHCCS----------------------------------- T ss_pred HHHHCCCCC----EEEEEEECCCCCCH-HHHHHHHHHHHHHCCCC----------------------------------- T ss_conf 576404886----89998216877557-88999998898740789----------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEE-ECCCCCCCHHHHHH Q ss_conf 45321368887532678950799961875567888635885568999999999999871841255-21233210345655 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIY-TTPFLANSLQSLIH 286 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiY-TS~~~~~nl~~Llh 286 (523) ++|+++|++|+| |.+++....|+ ++.+.-+|++..++ ||++...+...|.+ T Consensus 108 -----------------~~piiivgnK~D----l~~~~~v~~~~-------~~~~~~~~~~~~~~e~Sa~~g~gi~elf~ 159 (167) T d1c1ya_ 108 -----------------DVPMILVGNKCD----LEDERVVGKEQ-------GQNLARQWCNCAFLESSAKSKINVNEIFY 159 (167) T ss_dssp -----------------CCCEEEEEECTT----CGGGCCSCHHH-------HHHHHHHTTSCEEEECBTTTTBSHHHHHH T ss_pred -----------------CCEEEEEEECCC----CCCCCCCCHHH-------HHHHHHHHCCCEEEEEECCCCCCHHHHHH T ss_conf -----------------817999840468----52224679899-------99999983697189975158978889999 Q ss_pred HHC Q ss_conf 322 Q Fun_An_XP_0013 287 SSL 289 (523) Q Consensus 287 ~~l 289 (523) ..+ T Consensus 160 ~l~ 162 (167) T d1c1ya_ 160 DLV 162 (167) T ss_dssp HHH T ss_pred HHH T ss_conf 999 No 59 >2a9k_A RAS-related protein RAL-A; bacterial ADP-ribosyltransferase, RAL, RHO, GDP-binding; HET: GDP NAD; 1.73A {Homo sapiens} SCOP: c.37.1.8 Probab=97.75 E-value=0.0054 Score=41.87 Aligned_columns=165 Identities=15% Q ss_pred HHCCCCCEEEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECC Q ss_conf 40488420478864779873212323311112455663122565674444334202233100067745511016787178 Q Fun_An_XP_0013 40 NGKRLPEKNLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSE 119 (523) Q Consensus 40 s~~rlpsKnilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d 119 (523) +.++++-+.|+|+|....||++||..+.+..... +..... +-.|...-+.|.. .-.+.+|-. . T Consensus 12 ~~~~~~~~KI~ivG~~~vGKTsLl~~l~~~~~~~----~~~~T~--------~~~~~~~~~~~~~----~~~l~i~d~-~ 74 (187) T 2a9k_A 12 SQNSLALHKVIMVGSGGVGKSALTLQFMYDEFVE----DYEPTK--------ADSYRKKVVLDGE----EVQIDILDT-A 74 (187) T ss_dssp -----CEEEEEEECSTTSSHHHHHHHHHHSCCCC----SCCTTC--------CEEEEEEEEETTE----EEEEEEEEC-C T ss_pred CCCCCCEEEEEEEECCCCCHHHHHHHHHHCCCCC----CCCCEE--------EEEEEEEEEECCE----EEEEEEECC-C T ss_conf 7677424789998279987899999987064478----635406--------6435788762664----676666202-4 Q ss_pred CCHHHHHHHHHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCC Q ss_conf 87112320011058101200334333000031368999999999999998506958889999999998622688767777 Q Fun_An_XP_0013 120 PSLSFAPLLKPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSG 199 (523) Q Consensus 120 ~d~~~~~LLk~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~ 199 (523) +...+..+.+..+..-.. ++++.|.+++.++-. +..|...+......- T Consensus 75 g~~~~~~~~~~~~~~~d~----~i~v~d~~~~~s~~~-~~~~~~~~~~~~~~~--------------------------- 122 (187) T 2a9k_A 75 GQEDYAAIRDNYFRSGEG----FLCVFSITEMESFAA-TADFREQILRVKEDE--------------------------- 122 (187) T ss_dssp CTTCCHHHHHHHHHHCSE----EEEEEETTCHHHHHH-HHHHHHHHHHHHCCT--------------------------- T ss_pred CCCHHCCCCCCCCCCCCE----EEEEECCCCCHHHHH-HHHHHHHHHCCCCCC--------------------------- T ss_conf 720001010001235515----777521654002688-987642110025799--------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCC Q ss_conf 76777766453213688875326789507999618755678886358855689999999999998718412552123321 Q Fun_An_XP_0013 200 GAQGFTSSAGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLAN 279 (523) Q Consensus 200 ~~~~~~~s~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~ 279 (523) .+|++||++|+| |+.+.....++ ++.||-++|..+|.+|.+... T Consensus 123 -------------------------~~piiiv~nK~D----l~~~~~i~~~~-------~~~~~~~~~~~~~e~Sak~g~ 166 (187) T 2a9k_A 123 -------------------------NVPFLLVGNKSD----LEDKRQVSVEE-------AKNRAEQWNVNYVETSAKTRA 166 (187) T ss_dssp -------------------------TCCEEEEEECGG----GGGGCCSCHHH-------HHHHHHHTTCEEEECCTTTCT T ss_pred -------------------------CCEEEEECCCCC----CCCCCCCCHHH-------HHHHHHHCCCCEEEEECCCCC T ss_conf -------------------------727997347654----10015678899-------999999659938999616887 Q ss_pred CHHHHHHHHC Q ss_conf 0345655322 Q Fun_An_XP_0013 280 SLQSLIHSSL 289 (523) Q Consensus 280 nl~~Llh~~l 289 (523) ++..+.+... T Consensus 167 gi~e~f~~l~ 176 (187) T 2a9k_A 167 NVDKVFFDLM 176 (187) T ss_dssp THHHHHHHHH T ss_pred CHHHHHHHHH T ss_conf 8889999999 No 60 >pfam00071 Ras Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices. Probab=97.73 E-value=0.0029 Score=43.68 Aligned_columns=150 Identities=17% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+|+|..+.||++|+..+...+-.. +... -++..++ ...-..++..-.+++|=. .|.-.+ T Consensus 2 i~viG~~~vGKTsli~r~~~~~f~~----~~~~----------Ti~~~~~-~k~v~~~~~~~~l~i~Dt-~g~e~~---- 61 (162) T pfam00071 2 LVLVGDGGVGKSSLLIRFTQNKFPE----EYIP----------TIGVDFY-TKTIEVDGKTVKLQIWDT-AGQERF---- 61 (162) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCC----CCCC----------EEEEEEE-EEEEEECCEEEEEEEEEC-CCCCHH---- T ss_conf 7888179966899999986383276----5442----------0101578-999987367999999866-998013---- Q ss_pred HHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 110581012003-3433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 129 KPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 129 k~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) ..+.+..++++ .++|+-|.+..=+| +.+++|+..++++... T Consensus 62 -~~~~~~~~~~ad~~ilvfd~~~~~Sf-~~i~~w~~~i~~~~~~------------------------------------ 103 (162) T pfam00071 62 -RSLRPAYYRGAQGFLLVYDITSRDSF-ENVKKWLEEILRHADE------------------------------------ 103 (162) T ss_pred -HHHHHHHCCCCCEEEEEEECCCHHHH-HHHHHHHHHHHHHCCC------------------------------------ T ss_conf -56758650489889999877997899-9999999999984599------------------------------------ Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHH Q ss_conf 45321368887532678950799961875567888635885568999999999999871841255212332103456 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSL 284 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~L 284 (523) .+|+++|++|+| |+.++.-..++ .+.+|-++++..|.||.+...+.+.+ T Consensus 104 -----------------~~piilvgnK~D----l~~~~~i~~~e-------~~~~~~~~~~~y~e~Sak~g~gI~e~ 152 (162) T pfam00071 104 -----------------NVPIVLVGNKCD----LEDQRVVSTEE-------GEALAKELGLPFMETSAKTNTNVEEA 152 (162) T ss_pred -----------------CCEEEEEEECCH----HHHHCCCCHHH-------HHHHHHHCCCCEEEEECCCCCCHHHH T ss_conf -----------------948999850420----11211676889-------99999964995999971479888899 No 61 >cd04140 ARHI_like ARHI subfamily. ARHI (A Ras homolog member I) is a member of the Ras family with several unique structural and functional properties. ARHI is expressed in normal human ovarian and breast tissue, but its expression is decreased or eliminated in breast and ovarian cancer. ARHI contains an N-terminal extension of 34 residues (human) that is required to retain its tumor suppressive activity. Unlike most other Ras family members, ARHI is maintained in the constitutively active (GTP-bound) state in resting cells and has modest GTPase activity. ARHI inhibits STAT3 (signal transducers and activators of transcription 3), a latent transcription factor whose abnormal activation plays a critical role in oncogenesis. Most Ras proteins contain a lipid modification site at the C-terminus, with a typical sequence motif CaaX, where a = an aliphatic amino acid and X = any amino acid. Lipid binding is essential for membrane attachment, a key feature of most Ras proteins. Due to Probab=97.73 E-value=0.0034 Score=43.18 Aligned_columns=153 Identities=12% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|..+.||++|+..+....-.. ++.. -++-.|.-+...+... ..+.+|=. .|...|..+. T Consensus 4 IvliGd~~VGKTsli~r~~~~~F~~----~y~~----------ti~~~~~~~i~~~~~~--~~l~i~Dt-~G~e~~~~l~ 66 (165) T cd04140 4 VVVFGAGGVGKSSLVLRFVKGTFRE----SYIP----------TIEDTYRQVISCSKNI--CTLQITDT-TGSHQFPAMQ 66 (165) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCC----CCCC----------CEECEEEEEEEECCCE--EEEEEECC-CCCCCHHHHH T ss_conf 8998079965899998876282066----5454----------2001157788636948--99997037-7631023566 Q ss_pred HHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC Q ss_conf 11058101200334333000031368999999999999998506958889999999998622688767777767777664 Q Fun_An_XP_0013 129 KPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSSA 208 (523) Q Consensus 129 k~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s~ 208 (523) +..+.--+ .+||+-|.+++.+| +.+..|...+++.-..-... T Consensus 67 ~~~~~~a~----~~ilvydit~~~Sf-~~i~~~~~~i~~~~~~~~~~--------------------------------- 108 (165) T cd04140 67 RLSISKGH----AFILVYSVTSKQSL-EELKPIYELICEIKGNNIEK--------------------------------- 108 (165) T ss_pred HHHHCCCC----EEEEEEECCCHHHH-HHHHHHHHHHHHHHCCCCCC--------------------------------- T ss_conf 88621898----58999875997788-99999999999862248898--------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHH Q ss_conf 5321368887532678950799961875567888635885568999999999999871841255212332103456 Q Fun_An_XP_0013 209 GPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSL 284 (523) Q Consensus 209 ~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~L 284 (523) +|+++|-+|+| |+.++.-..++ .+.+|-++|+..|.||++...|...+ T Consensus 109 -----------------ipiilvGNK~D----l~~~r~V~~~e-------~~~~a~~~~~~~~E~SAk~~~nv~~~ 156 (165) T cd04140 109 -----------------IPIMLVGNKCD----ESHKREVSSNE-------GAACATEWNCAFMETSAKTNHNVQEL 156 (165) T ss_pred -----------------CEEEEEECCCC----CCCCCCCCHHH-------HHHHHHHCCCCEEEEECCCCCCHHHH T ss_conf -----------------57999503114----01046689899-------99999956995899971489887899 No 62 >2fv8_A H6, RHO-related GTP-binding protein RHOB; GDP/GTP binding, GTP hydrolysis, structural genomics, structural genomics consortium, SGC; HET: GDP; 1.90A {Homo sapiens} SCOP: c.37.1.8 Probab=97.73 E-value=0.00068 Score=47.74 Aligned_columns=179 Identities=13% Q ss_pred CCCCCEEEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCC Q ss_conf 48842047886477987321232331111245566312256567444433420223310006774551101678717887 Q Fun_An_XP_0013 42 KRLPEKNLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPS 121 (523) Q Consensus 42 ~rlpsKnilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d 121 (523) ..++.+.|+|+|..+.||++||..+....-.. .... .++..|.--..-+... ..+.+|-. .+. T Consensus 21 ~~~~~~KI~iiG~~~vGKSSLi~~l~~~~~~~----~~~~----------T~~~~~~~~i~~~~~~--~~l~i~D~-~g~ 83 (207) T 2fv8_A 21 QSMIRKKLVVVGDGACGKTCLLIVFSKDEFPE----VYVP----------TVFENYVADIEVDGKQ--VELALWDT-AGQ 83 (207) T ss_dssp GGSEEEEEEEEECTTSSHHHHHHHHHHSSCC---------------------CCEEEEEEEETTEE--EEEEEEEC-TTC T ss_pred HHHHCEEEEEEECCCCCHHHHHHHHHCCCCCC----CCCC----------EEEEEEEEEEEEEEEE--EEEECCCC-CCC T ss_conf 21300136688169977999999986174575----4453----------2552048999872055--64300455-320 Q ss_pred HHHHHHHHHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCC Q ss_conf 11232001105810120033433300003136899999999999999850695888999999999862268876777776 Q Fun_An_XP_0013 122 LSFAPLLKPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGA 201 (523) Q Consensus 122 ~~~~~LLk~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~ 201 (523) ..+..+.+..+. .-..++++.|.+.++++-.-.+.|+..++...... T Consensus 84 ~~~~~~~~~~~~----~~~~~ilv~d~~~~~Sf~~i~~~~~~~~~~~~~~~----------------------------- 130 (207) T 2fv8_A 84 EDYDRLRPLSYP----DTDVILMCFSVDSPDSLENIPEKWVPEVKHFCPNV----------------------------- 130 (207) T ss_dssp TTCTTTGGGGCT----TCCEEEEEEETTCHHHHHHHHHTHHHHHHHHSTTC----------------------------- T ss_pred HHHHHHHHHHHH----HHHHHHHEECCCHHHHHHHHHHHHHHHHHHHCCCE----------------------------- T ss_conf 122245677544----64510000114406789998887789986307963----------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHH-HHHHHHHHCC-EEEEECCCCCC Q ss_conf 777766453213688875326789507999618755678886358855689999999-9999987184-12552123321 Q Fun_An_XP_0013 202 QGFTSSAGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQF-MRTLLLKHGA-SLIYTTPFLAN 279 (523) Q Consensus 202 ~~~~~s~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~-lRt~cLqYGA-sLiYTS~~~~~ 279 (523) |+++|++|+|....-+-...+.+..-.-|-.- .++++.+++. ..|.||++... T Consensus 131 -------------------------piilVgnK~Dl~~~~~v~~~~~~~~~~~i~~~~~~~~~~~~~~~~~~e~Sa~~~~ 185 (207) T 2fv8_A 131 -------------------------PIILVANKKDLRSDEHVRTELARMKQEPVRTDDGRAMAVRIQAYDYLECSAKTKE 185 (207) T ss_dssp -------------------------CEEEEEECGGGGGCHHHHHHHHHTTCCCCCHHHHHHHHHHTTCSEEEECCTTTCT T ss_pred -------------------------EEEECCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEECCCCC T ss_conf -------------------------8997115877530124558899875122567899999997089518997516886 Q ss_pred CHHHHHHHHCCCCCCCCC Q ss_conf 034565532253224667 Q Fun_An_XP_0013 280 SLQSLIHSSLGIHSLLKR 297 (523) Q Consensus 280 nl~~Llh~~lgih~ll~~ 297 (523) ++..+.... +..++++ T Consensus 186 gi~e~f~~i--~~~~l~k 201 (207) T 2fv8_A 186 GVREVFETA--TRAALQK 201 (207) T ss_dssp THHHHHHHH--HHHHHSC T ss_pred CHHHHHHHH--HHHHHHH T ss_conf 778999999--9999998 No 63 >2bov_A RAla, RAS-related protein RAL-A; C3BOT, exoenzyme, RAla, GTPase, ribosylating toxin, GTP-binding, lipoprotein, prenylation; HET: GDP; 2.66A {Homo sapiens} Probab=97.72 E-value=0.0057 Score=41.73 Aligned_columns=156 Identities=16% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|..+.||+||+..+.+..... +..... +-.|.+.-..+.. ..++.+|-.+..+-+....- T Consensus 17 I~iiG~~~vGKTsLi~~l~~~~~~~----~~~~t~--------~~~~~~~~~~~~~----~~~l~i~d~~g~~~~~~~~~ 80 (206) T 2bov_A 17 VIMVGSGGVGKSALTLQFMYDEFVE----DYEPTK--------ADSYRKKVVLDGE----EVQIDILDTAGQEDYAAIRD 80 (206) T ss_dssp EEEECSTTSSHHHHHHHHHHSCCCT----TCCTTC--------CEEEEEEEEETTE----EEEEEEEECCCTTCCHHHHH T ss_pred EEEEECCCCCHHHHHHHHHCCCCCC----CCCCCE--------EEEEEEEEEECCE----EEEEEEEECCCCCCCCCCCC T ss_conf 9998279987899999986283167----525630--------4578999983474----89998730247431131000 Q ss_pred HHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC Q ss_conf 11058101200334333000031368999999999999998506958889999999998622688767777767777664 Q Fun_An_XP_0013 129 KPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSSA 208 (523) Q Consensus 129 k~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s~ 208 (523) .+.-.+. .++++.|.+.+.++-+ +..|...+......- T Consensus 81 ~~~~~~~-----~~i~v~d~~~~~s~~~-~~~~~~~~~~~~~~~------------------------------------ 118 (206) T 2bov_A 81 NYFRSGE-----GFLCVFSITEMESFAA-TADFREQILRVKEDE------------------------------------ 118 (206) T ss_dssp HHHHHCS-----EEEEEEETTCHHHHHH-HHHHHHHHHHHTTCS------------------------------------ T ss_pred CCCCCCC-----EEEEEECCCCHHHHHH-HHHHHHHHHHCCCCC------------------------------------ T ss_conf 0011220-----1122211432001688-998866643114799------------------------------------ Q ss_pred CCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHH Q ss_conf 53213688875326789507999618755678886358855689999999999998718412552123321034565532 Q Fun_An_XP_0013 209 GPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIHSS 288 (523) Q Consensus 209 ~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh~~ 288 (523) .+|+++|++|+| |+.......+. ++.|+-+||+..|.+|++...++..+.... T Consensus 119 ----------------~~piilv~nK~D----l~~~~~v~~~~-------~~~~~~~~~~~~~~~Sa~~~~~i~~~f~~l 171 (206) T 2bov_A 119 ----------------NVPFLLVGNKSD----LEDKRQVSVEE-------AKNRAEQWNVNYVETSAKTRANVDKVFFDL 171 (206) T ss_dssp ----------------CCCEEEEEECTT----CGGGCCSCHHH-------HHHHHHHHTCEEEEECTTTCTTHHHHHHHH T ss_pred ----------------CCEEEEECCCCC----CHHCCCCCHHH-------HHHHHHHCCCCEEEEEECCCCCHHHHHHHH T ss_conf ----------------707997147644----00104678899-------999999648955898605898888999999 Q ss_pred C Q ss_conf 2 Q Fun_An_XP_0013 289 L 289 (523) Q Consensus 289 l 289 (523) + T Consensus 172 ~ 172 (206) T 2bov_A 172 M 172 (206) T ss_dssp H T ss_pred H T ss_conf 9 No 64 >1kao RAP2A; GTP-binding protein, small G protein, GDP, RAS; HET: GDP; 1.7A {Homo sapiens} SCOP: c.37.1.8 Probab=97.72 E-value=0.005 Score=42.09 Aligned_columns=154 Identities=14% Q ss_pred EEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHH Q ss_conf 47886477987321232331111245566312256567444433420223310006774551101678717887112320 Q Fun_An_XP_0013 48 NLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPL 127 (523) Q Consensus 48 nilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~L 127 (523) .|+++|..+.||+|||.++.+..... ..+|....+-....+++-.. -.+..|-.+..+.+.... T Consensus 5 Ki~liG~~~vGKTSll~~l~~~~~~~---------~~~~t~~~~~~~~~~~~~~~-------~~~~~~d~~g~~~~~~~~ 68 (167) T 1kao 5 KVVVLGSGGVGKSALTVQFVTGTFIE---------KYDPTIEDFYRKEIEVDSSP-------SVLEILDTAGTEQFASMR 68 (167) T ss_dssp EEEEECCTTSSHHHHHHHHHHSCCCS---------CCCTTCCEEEEEEEEETTEE-------EEEEEEECCCTTCCHHHH T ss_pred EEEEEECCCCCHHHHHHHHHCCCCCC---------CCCCCCEEEEEEEEECCCEE-------EEEEEECCCCCCCHHHHH T ss_conf 89988079987899999986482365---------53442025776643048826-------888753056753013567 Q ss_pred HHHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 01105810120033433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 128 LKPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 128 Lk~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) ..+.-.+ -.++++.|.+.+++ .+.+.+|..-+......- T Consensus 69 ~~~~~~~-----~~~i~v~d~~~~~s-~~~~~~~~~~~~~~~~~~----------------------------------- 107 (167) T 1kao 69 DLYIKNG-----QGFILVYSLVNQQS-FQDIKPMRDQIIRVKRYE----------------------------------- 107 (167) T ss_dssp HHHHHHC-----SEEEEEEETTCHHH-HHHHHHHHHHHHHHTTTS----------------------------------- T ss_pred HHHHHCC-----CEEEEEECCCCCHH-HHHHHHHHHHHHHHCCCC----------------------------------- T ss_conf 7775201-----20133322431012-211124456776420345----------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHH Q ss_conf 4532136888753267895079996187556788863588556899999999999987184125521233210345655 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIH 286 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh 286 (523) .+|++||.+|+| ++....-..+. ++++|.++++.+|-||.+...+...|.. T Consensus 108 -----------------~~piiiv~nK~D----l~~~~~v~~~~-------~~~~~~~~~~~~~~~Sa~~~~gi~elf~ 158 (167) T 1kao 108 -----------------KVPVILVGNKVD----LESEREVSSSE-------GRALAEEWGCPFMETSAKSKTMVDELFA 158 (167) T ss_dssp -----------------CCCEEEEEECGG----GGGGCCSCHHH-------HHHHHHHHTSCEEEECTTCHHHHHHHHH T ss_pred -----------------CCEEEEEECCCC----CCCCCCCCHHH-------HHHHHHHCCCCEEEEECCCCCCHHHHHH T ss_conf -----------------411345311221----00001578889-------9999996498089986268868789999 No 65 >e2atxa1 c.37.1.8 (A:9-193) RhoQ {Human (Homo sapiens) [TaxID:9606]} SCOP: u2atxb_ Probab=97.71 E-value=0.002 Score=44.72 Aligned_columns=163 Identities=15% Q ss_pred EEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHH Q ss_conf 47886477987321232331111245566312256567444433420223310006774551101678717887112320 Q Fun_An_XP_0013 48 NLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPL 127 (523) Q Consensus 48 nilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~L 127 (523) +|+|+|..+.||+||+..+....... +..... +-.|...-..+.. .-++.+|=. .|...+..+ T Consensus 11 ki~viG~~~vGKTsli~~~~~~~~~~----~~~~t~--------~~~~~~~i~~~~~----~~~l~i~D~-~g~~~~~~~ 73 (185) T e2atxa1 11 KCVVVGDGAVGKTCLLMSYANDAFPE----EYVPTV--------FDHYAVSVTVGGK----QYLLGLYDT-AGQEDYDRL 73 (185) T ss_pred EEEEEECCCCCHHHHHHHHHCCCCCC----CCCCEE--------EEEEEEEEEECCC----EEEEEEEEC-CCCCHHHHH T ss_conf 99998069988999999986383267----635516--------8888899987396----489998505-573112333 Q ss_pred HHHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 01105810120033433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 128 LKPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 128 Lk~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) .+..+..-. .++||.|.++|++|-.-.+.|...++.+.. T Consensus 74 ~~~~~~~~d----~~i~v~D~~~~~S~~~~~~~~~~~~~~~~~------------------------------------- 112 (185) T e2atxa1 74 RPLSYPMTD----VFLICFSVVNPASFQNVKEEWVPELKEYAP------------------------------------- 112 (185) T ss_pred HHHHCCCCE----EEEEEEECCCCCHHHHHHHHHHHHHHHHCC------------------------------------- T ss_conf 454314342----567887435740278877888999986079------------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHH-HHHHHHHHHHHCCEEEE-ECCCCCCCHHHHH Q ss_conf 453213688875326789507999618755678886358855689999-99999999871841255-2123321034565 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFI-LQFMRTLLLKHGASLIY-TTPFLANSLQSLI 285 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfI-qQ~lRt~cLqYGAsLiY-TS~~~~~nl~~Ll 285 (523) .+|+++|.+|+|....-..+....+..-.-| ++..++++-++|+-.++ +|.+...|+..+. T Consensus 113 -----------------~~piiivgnK~Dl~~~~~~~~~~~~~~~~~v~~~~~~~~a~~~~~~~~~e~Sa~t~~gi~e~f 175 (185) T e2atxa1 113 -----------------NVPFLLIGTQIDLRDDPKTLARLNDMKEKPICVEQGQKLAKEIGACCYVECSALTQKGLKTVF 175 (185) T ss_pred -----------------CCEEEEEEECCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHH T ss_conf -----------------707999972358765124666554411466788999999997089137887505787878999 No 66 >d1g16a_ c.37.1.8 (A:) Rab-related protein Sec4 {Baker's yeast (Saccharomyces cerevisiae)} SCOP: d1g16b_ d1g16c_ d1g16d_ Probab=97.70 E-value=0.0065 Score=41.35 Aligned_columns=153 Identities=16% Q ss_pred EEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHH Q ss_conf 47886477987321232331111245566312256567444433420223310006774551101678717887112320 Q Fun_An_XP_0013 48 NLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPL 127 (523) Q Consensus 48 nilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~L 127 (523) .|+++|..+.||++|+..+...+... +....- +..+.+..+...+.. .++.+|-. .|...+ T Consensus 4 Ki~iiG~~~vGKTsli~~~~~~~~~~----~~~~~~--------~~~~~~~~~~~~~~~---~~~~i~D~-~g~~~~--- 64 (166) T d1g16a_ 4 KILLIGDSGVGKSCLLVRFVEDKFNP----SFITTI--------GIDFKIKTVDINGKK---VKLQIWDT-AGQERF--- 64 (166) T ss_dssp EEEEEESTTSSHHHHHHHHHHCCCCC-------------------CCEEEEEEESSSCE---EEEEEECC-TTGGGT--- T ss_pred EEEEEECCCCCHHHHHHHHHCCCCCC----CCCCCC--------CEEEEEEEEEECCCE---EEEEEEEC-CCCCHH--- T ss_conf 89998079987999999986480067----623444--------215789999872874---89997306-883001--- Q ss_pred HHHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC Q ss_conf 0110581012003-343330000313689999999999999985069588899999999986226887677777677776 Q Fun_An_XP_0013 128 LKPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTS 206 (523) Q Consensus 128 Lk~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~ 206 (523) ..+.+..++.+ .++++.|.++|=++ +.+.+|+..++..-.. T Consensus 65 --~~~~~~~~~~~~~~i~v~d~~~~~s~-~~~~~~~~~i~~~~~~----------------------------------- 106 (166) T d1g16a_ 65 --RTITTAYYRGAMGIILVYDITDERTF-TNIKQWFKTVNEHAND----------------------------------- 106 (166) T ss_dssp --SCCCHHHHTTEEEEEEEEETTCHHHH-HTHHHHHHHHHHHSCT----------------------------------- T ss_pred --HHHHHHHHCCCCEEEEEEECCCCCHH-HHHHHHHHHHHHHCCC----------------------------------- T ss_conf --11104450488489998513463102-3433678999973047----------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHH Q ss_conf 64532136888753267895079996187556788863588556899999999999987184125521233210345655 Q Fun_An_XP_0013 207 SAGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIH 286 (523) Q Consensus 207 s~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh 286 (523) .+|++||++|+|. .++.-..|+ ++.++-++|+..|.+|.+...+...+.. T Consensus 107 ------------------~~~iivv~nK~Dl-----~~~~i~~~~-------~~~~~~~~~~~~~e~Sa~~g~gi~e~f~ 156 (166) T d1g16a_ 107 ------------------EAQLLLVGNKSDM-----ETRVVTADQ-------GEALAKELGIPFIESSAKNDDNVNEIFF 156 (166) T ss_dssp ------------------TCEEEEEEECTTC-----TTCCSCHHH-------HHHHHHHHTCCEEECBTTTTBSHHHHHH T ss_pred ------------------CCCEEEEECCCCH-----HHCCCCHHH-------HHHHHHHCCCCEEEEECCCCCCHHHHHH T ss_conf ------------------7530100000002-----210686899-------9999996499289996158988889999 Q ss_pred H Q ss_conf 3 Q Fun_An_XP_0013 287 S 287 (523) Q Consensus 287 ~ 287 (523) . T Consensus 157 ~ 157 (166) T d1g16a_ 157 T 157 (166) T ss_dssp H T ss_pred H T ss_conf 9 No 67 >1z06_A RAS-related protein RAB-33B; RAB GTPase, RAB33B GTPase, vesicular trafficking, protein transport; HET: GNP; 1.81A {Mus musculus} SCOP: c.37.1.8 Probab=97.70 E-value=0.0016 Score=45.23 Aligned_columns=153 Identities=13% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+|+|..+.||++|+..+.+.............. |.+..+...++. -.+..|............. T Consensus 23 v~ivG~~~vGKTsLi~~l~~~~~~~~~~~t~~~~------------~~~~~~~~~~~~---~~~~~~d~~g~~~~~~~~~ 87 (189) T 1z06_A 23 IIVIGDSNVGKTCLTYRFCAGRFPDRTEATIGVD------------FRERAVDIDGER---IKIQLWDTAGQERFRKSMV 87 (189) T ss_dssp EEEECCTTSSHHHHHHHHHHSSCCSSCCCCCSCC------------EEEEEEEETTEE---EEEEEEECCCSHHHHTTTH T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEEE------------EEEEEEEECCCC---CEEEEEECCCCHHHHHHHH T ss_conf 9998169987899999986381266624204445------------643567740424---3688840567213433100 Q ss_pred HHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC Q ss_conf 11058101200334333000031368999999999999998506958889999999998622688767777767777664 Q Fun_An_XP_0013 129 KPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSSA 208 (523) Q Consensus 129 k~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s~ 208 (523) +..+. .-..++++.|.+.|.++ +.+.+|..-++.++.. T Consensus 88 ~~~~~----~~~~~i~v~d~~~~~s~-~~i~~~~~~i~~~~~~------------------------------------- 125 (189) T 1z06_A 88 QHYYR----NVHAVVFVYDMTNMASF-HSLPAWIEECKQHLLA------------------------------------- 125 (189) T ss_dssp HHHHT----TCCEEEEEEETTCHHHH-HTHHHHHHHHHHHCCC------------------------------------- T ss_pred HHHCC----CCCEEEEEEECCCCHHH-HHHHHHHHHHHHHCCC------------------------------------- T ss_conf 32304----66668998732553025-7899999875321026------------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHH Q ss_conf 5321368887532678950799961875567888635885568999999999999871841255212332103456 Q Fun_An_XP_0013 209 GPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSL 284 (523) Q Consensus 209 ~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~L 284 (523) -.+|+++|++|+|. .+......+-++.||-++|...|-||.+-..+...+ T Consensus 126 ---------------~~~piilvgnK~Dl-----------~~~~~i~~~~~~~~~~~~~~~~~e~Sak~~~~~~~i 175 (189) T 1z06_A 126 ---------------NDIPRILVGNKCDL-----------RSAIQVPTDLAQKFADTHSMPLFETSAKNPNDNDHV 175 (189) T ss_dssp ---------------SCCCEEEEEECTTC-----------GGGCCSCHHHHHHHHHHTTCCEEECCSSSGGGGSCH T ss_pred ---------------CCCEEEEEEECCCC-----------CCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCH T ss_conf ---------------89579999606784-----------300247889999999955991899840458888577 No 68 >2cjw_A GTP-binding protein GEM; RAS-like protein KIR; nucleotide-binding, small GTPase, conformational change, cysteine-modified, G-protein hydrolase; HET: GDP; 2.10A {Homo sapiens} Probab=97.70 E-value=0.0042 Score=42.58 Aligned_columns=158 Identities=15% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+|+|..+.||++|+..++... .......... +..+.-..|.-...+-....+.+|-. .|.-.+ T Consensus 9 I~iiG~~~vGKTsli~r~~~~~---~~~~~~~~~~--------~~~~~~~~~~~~~~~~~~~~~~i~d~-~g~e~~---- 72 (192) T 2cjw_A 9 VVLIGEQGVGKSTLANIFAGVH---DSMDSDXEVL--------GEDTYERTLMVDGESATIILLDMWEN-KGENEW---- 72 (192) T ss_dssp EEEECSTTSSHHHHHHHHHHHS---CC----CGGG--------CTTEEEEEEEETTEEEEEEEECCC-----CCCT---- T ss_pred EEEEECCCCCHHHHHHHHHCCC---CCCCCCCCCE--------EEEEEEEEECCCCCEEEEEEEEEEEE-HHHHHH---- T ss_conf 9998179987999999986365---5534445523--------78888886225682256787642000-000000---- Q ss_pred HHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 110581012003-3433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 129 KPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 129 k~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) +....++.+ .++++.|.+.+.++.. +++|..-++.+...- T Consensus 73 ---~~~~~~~~~~~~ilv~di~~~~s~~~-~~~~~~~i~~~~~~~----------------------------------- 113 (192) T 2cjw_A 73 ---LHDHCMQVGDAYLIVYSITDRASFEK-ASELRIQLRRARQTE----------------------------------- 113 (192) T ss_dssp ---TGGGHHHHCSEEEEEEETTCHHHHHH-HHHHHHHHHHHTTTS----------------------------------- T ss_pred ---HHHHHHHHHHHHHHHEEECCCCCHHH-HHHHHHHHHHHCCCC----------------------------------- T ss_conf ---00232100112211100012346236-789998875411468----------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHH Q ss_conf 45321368887532678950799961875567888635885568999999999999871841255212332103456553 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIHS 287 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh~ 287 (523) .+|+++|++|+| |+..+....++ .+.+|..||...+-+|.+...+...|... T Consensus 114 -----------------~~piiivgnK~D----l~~~~~i~~~e-------~~~~~~~~~~~~~e~Sak~g~gi~~~f~~ 165 (192) T 2cjw_A 114 -----------------DIPIILVGNKSD----LVRXREVSVSE-------GRAXAVVFDXKFIETSAAVQHNVKELFEG 165 (192) T ss_dssp -----------------CCCEEEEEECTT----CGGGCCSCHHH-------HHHHHHHTTCEEEECBTTTTBSHHHHHHH T ss_pred -----------------CEEEEEECCCCC----HHHCCCCCHHH-------HHHHHHHCCCEEEEEEECCCCCHHHHHHH T ss_conf -----------------702898505644----10225778899-------98899863880899960488788899999 Q ss_pred HC Q ss_conf 22 Q Fun_An_XP_0013 288 SL 289 (523) Q Consensus 288 ~l 289 (523) .. T Consensus 166 i~ 167 (192) T 2cjw_A 166 IV 167 (192) T ss_dssp HH T ss_pred HH T ss_conf 99 No 69 >2gf9_A RAS-related protein RAB-3D; G-protein, structural genomics, structural genomics consortium, SGC; HET: GDP; 1.53A {Homo sapiens} Probab=97.68 E-value=0.0083 Score=40.66 Aligned_columns=156 Identities=19% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+|+|..+.||++|+..+....... .....- +..+.+..+...++. .++.+|-. .|...+..+. T Consensus 25 I~iiG~~~vGKSsLi~~l~~~~~~~----~~~~t~--------~~~~~~~~~~~~~~~---v~~~i~D~-~g~~~~~~~~ 88 (189) T 2gf9_A 25 LLLIGNSSVGKTSFLFRYADDSFTP----AFVSTV--------GIDFKVKTVYRHDKR---IKLQIWDT-AGQERYRTIT 88 (189) T ss_dssp EEEECSTTSSHHHHHHHHHHSCCCC----SCCCCC--------CCEEEEEEEEETTEE---EEEEEEEC-CSCCSSCCSG T ss_pred EEEEECCCCCHHHHHHHHHCCCCCC----CCCCCE--------ECCCEEEEEEECCEE---EEEEEECC-CCCCHHHHHH T ss_conf 9998179987899999986480364----524210--------012102445421158---99988406-7742134555 Q ss_pred HHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC Q ss_conf 11058101200334333000031368999999999999998506958889999999998622688767777767777664 Q Fun_An_XP_0013 129 KPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSSA 208 (523) Q Consensus 129 k~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s~ 208 (523) ...... -..++|+.|.+.+.++ +.+++|...++..... T Consensus 89 ~~~~~~----~~~~iivfd~~~~~S~-~~~~~~~~~~~~~~~~------------------------------------- 126 (189) T 2gf9_A 89 TAYYRG----AMGFLLMYDIANQESF-AAVQDWATQIKTYSWD------------------------------------- 126 (189) T ss_dssp GGGGTT----CSEEEEEEETTCHHHH-HTHHHHHHHHHHHSCT------------------------------------- T ss_pred HHHCCC----CEEEEEEEECCCCHHH-HHHHHHHCCCCCCCCC------------------------------------- T ss_conf 876059----7189999850330123-3332100000102246------------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHH Q ss_conf 53213688875326789507999618755678886358855689999999999998718412552123321034565532 Q Fun_An_XP_0013 209 GPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIHSS 288 (523) Q Consensus 209 ~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh~~ 288 (523) .+|++||++|+| |..++.-..++ ++.++-+++..+|.||.+...++..|.... T Consensus 127 ----------------~~piiivgnK~D----l~~~~~v~~~e-------~~~~a~~~~~~~~e~Sa~~~~gI~elf~~i 179 (189) T 2gf9_A 127 ----------------NAQVILVGNKCD----LEDERVVPAED-------GRRLADDLGFEFFEASAKENINVKQVFERL 179 (189) T ss_dssp ----------------TCEEEEEEECTT----CGGGCCSCHHH-------HHHHHHHHTCEEEECBTTTTBSHHHHHHHH T ss_pred ----------------CEEEEEECCCCC----CHHHHHHHHHH-------HHHHHHHCCCCEEEEECCCCCCHHHHHHHH T ss_conf ----------------624775013232----01232001789-------999999659918999626897889999999 Q ss_pred C Q ss_conf 2 Q Fun_An_XP_0013 289 L 289 (523) Q Consensus 289 l 289 (523) + T Consensus 180 ~ 180 (189) T 2gf9_A 180 V 180 (189) T ss_dssp H T ss_pred H T ss_conf 9 No 70 >d1oiva_ c.37.1.8 (A:) Rab11a {Human (Homo sapiens)} Probab=97.68 E-value=0.0044 Score=42.45 Aligned_columns=156 Identities=15% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|..+.||+||+..+.+..... .... ..+..+....-.-.... -++.+|-. .|...+..+- T Consensus 9 i~ivG~~~vGKSSLi~~l~~~~~~~----~~~~----------~~~~~~~~~~~~~~~~~-~~~~i~D~-~g~~~~~~~~ 72 (168) T d1oiva_ 9 VVLIGDSGVGKSNLLSRFTRNEFNL----ESKS----------TIGVEFATRSIQVDGKT-IKAQIWDT-AGQERYRAIT 72 (168) T ss_dssp EEEESSTTSSHHHHHHHHHHSCCCS----SCCC----------CSSEEEEEEEEEETTEE-EEEEEEEE-CSCCCCHHHH T ss_pred EEEEECCCCCHHHHHHHHHCCCCCC----CCCC----------EEEEEEEEEEEEECCEE-EEEEEECC-CCCCHHHHHH T ss_conf 9998369987999999986580343----6553----------26533422789988948-99998506-7830123555 Q ss_pred HHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC Q ss_conf 11058101200334333000031368999999999999998506958889999999998622688767777767777664 Q Fun_An_XP_0013 129 KPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSSA 208 (523) Q Consensus 129 k~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s~ 208 (523) +..+.--.. ++|+.|-+.+.++-. +.+|+.-++...... T Consensus 73 ~~~~~~~d~----~i~v~d~~~~~s~~~-i~~~~~~i~~~~~~~------------------------------------ 111 (168) T d1oiva_ 73 SAYYRGAVG----ALLVYDIAKHLTYEN-VERWLKELRDHADSN------------------------------------ 111 (168) T ss_dssp HHHHTTEEE----EEEEEETTCHHHHHT-HHHHHHHHHHHSCTT------------------------------------ T ss_pred HHHHCCCCE----EEEEEEECCCCHHHH-HHHHHHHHHHHCCCC------------------------------------ T ss_conf 776227878----999998426301688-999999998614895------------------------------------ Q ss_pred CCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHH Q ss_conf 53213688875326789507999618755678886358855689999999999998718412552123321034565532 Q Fun_An_XP_0013 209 GPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIHSS 288 (523) Q Consensus 209 ~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh~~ 288 (523) +|++||++|+| |++++.-..|+ .+.+|-++|+..|-||.+...++..+.... T Consensus 112 -----------------~piiivgnK~D----l~~~~~v~~~~-------~~~~~~~~~~~~~e~Sak~g~~i~e~f~~i 163 (168) T d1oiva_ 112 -----------------IVIMLVGNKSD----LRHLRAVPTDE-------ARAFAEKNGLSFIETSALDSTNVEAAFQTI 163 (168) T ss_dssp -----------------CEEEEEEECTT----CGGGCCSCHHH-------HHHHHHHHTCEEEECCTTTCTTHHHHHHHH T ss_pred -----------------EEEEEEEECCC----HHHCCCCCHHH-------HHHHHHHCCCCEEEEECCCCCCHHHHHHHH T ss_conf -----------------38996110001----22203779899-------999999639938999716897878999999 Q ss_pred C Q ss_conf 2 Q Fun_An_XP_0013 289 L 289 (523) Q Consensus 289 l 289 (523) + T Consensus 164 i 164 (168) T d1oiva_ 164 L 164 (168) T ss_dssp H T ss_pred H T ss_conf 9 No 71 >cd04127 Rab27A Rab27a subfamily. The Rab27a subfamily consists of Rab27a and its highly homologous isoform, Rab27b. Unlike most Rab proteins whose functions remain poorly defined, Rab27a has many known functions. Rab27a has multiple effector proteins, and depending on which effector it binds, Rab27a has different functions as well as tissue distribution and/or cellular localization. Putative functions have been assigned to Rab27a when associated with the effector proteins Slp1, Slp2, Slp3, Slp4, Slp5, DmSlp, rabphilin, Dm/Ce-rabphilin, Slac2-a, Slac2-b, Slac2-c, Noc2, JFC1, and Munc13-4. Rab27a has been associated with several human diseases, including hemophagocytic syndrome (Griscelli syndrome or GS), Hermansky-Pudlak syndrome, and choroidermia. In the case of GS, a rare, autosomal recessive disease, a Rab27a mutation is directly responsible for the disorder. When Rab27a is localized to the secretory granules of pancreatic beta cells, it is believed to mediate glucose-stimulated Probab=97.68 E-value=0.0044 Score=42.45 Aligned_columns=160 Identities=21% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCC-------CCCCCEEEEEEECCCC Q ss_conf 788647798732123233111124556631225656744443342022331000677-------4551101678717887 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADH-------EDTLARVSAYLLSEPS 121 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~-------eD~~aR~svyiL~d~d 121 (523) |+|+|+.+.||++|+..+...+-.. .+..-- |+++..-.+.-+.. +...-.+.+|=. .|. T Consensus 7 ivviGd~~vGKTsli~r~~~~~f~~----~~~~Ti--------g~~~~~k~i~~~~~~~~~~~~~~~~v~l~iwDt-aGq 73 (180) T cd04127 7 FLALGDSGVGKTSFLYQYTDNKFNP----KFITTV--------GIDFREKRVVYNSSGPGGTLGRGQRIHLQLWDT-AGQ 73 (180) T ss_pred EEEEECCCCCHHHHHHHHHCCEECC----CCCCEE--------EEEEEEEEEEEECCCCCCCCCCCCEEEEEEEEC-CCC T ss_conf 9998069843899988876383277----635401--------113557799971255433245772799999724-776 Q ss_pred HHHHHHHHHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCC Q ss_conf 11232001105810120033433300003136899999999999999850695888999999999862268876777776 Q Fun_An_XP_0013 122 LSFAPLLKPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGA 201 (523) Q Consensus 122 ~~~~~LLk~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~ 201 (523) -.|..+.+....--.. ++|+-|-+.+.++-. +..|+..++.+..+- T Consensus 74 e~~~~l~~~~~~~a~~----~ilvydit~~~Sf~~-~~~w~~~i~~~~~~~----------------------------- 119 (180) T cd04127 74 ERFRSLTTAFFRDAMG----FLLIFDLTNEQSFLN-VRNWMSQLQTHAYCE----------------------------- 119 (180) T ss_pred CHHHHHHHHHCCCCCE----EEEEEECCCHHHHHH-HHHHHHHHHHHCCCC----------------------------- T ss_conf 2145676886049988----999974689668899-999999998613678----------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCH Q ss_conf 77776645321368887532678950799961875567888635885568999999999999871841255212332103 Q Fun_An_XP_0013 202 QGFTSSAGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSL 281 (523) Q Consensus 202 ~~~~~s~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl 281 (523) .+|+++|++|+| |++++.-..++ .+.+|=++|+..|.||++...|. T Consensus 120 -----------------------~~~ivlVgNK~D----l~~~r~Vs~~e-------~~~~a~~~~~~~~e~SAk~~~nV 165 (180) T cd04127 120 -----------------------NPDIVLCGNKAD----LEDQRQVSEEQ-------AKALADKYGIPYFETSAATGTNV 165 (180) T ss_pred -----------------------CCEEEEEECCCC----CCCCCCCCHHH-------HHHHHHHCCCCEEEEECCCCCCH T ss_conf -----------------------750788720235----52112248789-------99999965995999971479887 Q ss_pred HHHHHHHC Q ss_conf 45655322 Q Fun_An_XP_0013 282 QSLIHSSL 289 (523) Q Consensus 282 ~~Llh~~l 289 (523) ..+..... T Consensus 166 ~e~F~~l~ 173 (180) T cd04127 166 EKAVERLL 173 (180) T ss_pred HHHHHHHH T ss_conf 89999999 No 72 >1z08_A RAS-related protein RAB-21; RAB GTPase, vesicular trafficking, protein transport; HET: GNP; 1.80A {Homo sapiens} SCOP: c.37.1.8 Probab=97.68 E-value=0.02 Score=38.12 Aligned_columns=164 Identities=18% Q ss_pred HCCCCCEEEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCC Q ss_conf 04884204788647798732123233111124556631225656744443342022331000677455110167871788 Q Fun_An_XP_0013 41 GKRLPEKNLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEP 120 (523) Q Consensus 41 ~~rlpsKnilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~ 120 (523) ++|-.+=.|+|+|..+.||++||..+.+..... .....- +..+.+..+...+.. -++.+|-. .+ T Consensus 1 ~~~~~~~Ki~ivG~~~vGKSsLi~~l~~~~~~~----~~~~~~--------~~~~~~~~~~~~~~~---~~l~~~d~-~~ 64 (170) T 1z08_A 1 GSRAYSFKVVLLGEGCVGKTSLVLRYCENKFND----KHITTL--------GASFLTKKLNIGGKR---VNLAIWDT-AG 64 (170) T ss_dssp ---CEEEEEEEECCTTSCHHHHHHHHHHCCCCS----SCCCCC--------SCEEEEEEEESSSCE---EEEEEEEC-CC T ss_pred CCCCEEEEEEEEECCCCCHHHHHHHHHCCCCCC----CCCCCC--------CCEEEEEEECCCCEE---EEEEEECC-CC T ss_conf 970106788998179977899999986580365----444323--------320113330266147---88753013-21 Q ss_pred CHHHHHHHHHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCC Q ss_conf 71123200110581012003343330000313689999999999999985069588899999999986226887677777 Q Fun_An_XP_0013 121 SLSFAPLLKPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGG 200 (523) Q Consensus 121 d~~~~~LLk~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~ 200 (523) ...+..+.+.....-. .++++.|.+.+.++-. +.+|+..++...... T Consensus 65 ~~~~~~~~~~~~~~~~----~~i~v~d~~~~~s~~~-~~~~~~~~~~~~~~~---------------------------- 111 (170) T 1z08_A 65 QERFHALGPIYYRDSN----GAILVYDITDEDSFQK-VKNWVKELRKMLGNE---------------------------- 111 (170) T ss_dssp C-------CCSSTTCS----EEEEEEETTCHHHHHH-HHHHHHHHHHHHGGG---------------------------- T ss_pred HHHHCCCCHHHHCCCC----EEEEEECCCCCCCCHH-HHHHHHHHCCCCCCC---------------------------- T ss_conf 0000112302220562----5788731432332000-112110000024555---------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCC Q ss_conf 67777664532136888753267895079996187556788863588556899999999999987184125521233210 Q Fun_An_XP_0013 201 AQGFTSSAGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANS 280 (523) Q Consensus 201 ~~~~~~s~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~n 280 (523) +|+++|++|+| |.+++.-..++ ++.++-++|+..|.+|.+...+ T Consensus 112 -------------------------~p~ilVgnK~D----l~~~~~i~~~~-------~~~~~~~~~~~~~e~Sa~~g~g 155 (170) T 1z08_A 112 -------------------------ICLCIVGNKID----LEKERHVSIQE-------AESYAESVGAKHYHTSAKQNKG 155 (170) T ss_dssp -------------------------SEEEEEEECGG----GGGGCCSCHHH-------HHHHHHHTTCEEEEEBTTTTBS T ss_pred -------------------------CCEEECCCCCH----HHHHCCCCHHH-------HHHHHHHCCCCEEEEECCCCCC T ss_conf -------------------------42122034401----11110345789-------9999996499389996158978 Q ss_pred HHHHHHHHC Q ss_conf 345655322 Q Fun_An_XP_0013 281 LQSLIHSSL 289 (523) Q Consensus 281 l~~Llh~~l 289 (523) ...|+.... T Consensus 156 i~~lf~~i~ 164 (170) T 1z08_A 156 IEELFLDLC 164 (170) T ss_dssp HHHHHHHHH T ss_pred HHHHHHHHH T ss_conf 889999999 No 73 >1vg8_A RAS-related protein RAB-7; GTP-binding protein; HET: GNP; 1.70A {Rattus norvegicus} SCOP: c.37.1.8 Probab=97.67 E-value=0.0097 Score=40.23 Aligned_columns=165 Identities=18% Q ss_pred HHCCCCCEEEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECC Q ss_conf 40488420478864779873212323311112455663122565674444334202233100067745511016787178 Q Fun_An_XP_0013 40 NGKRLPEKNLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSE 119 (523) Q Consensus 40 s~~rlpsKnilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d 119 (523) +++|---..|+|+|....||+||+..+....-.. .....- +..|....+...... .++.+|-. . T Consensus 2 ~~~k~~~~KI~iiG~~~vGKSsLi~~l~~~~~~~----~~~~ti--------~~~~~~~~~~~~~~~---~~~~i~D~-~ 65 (207) T 1vg8_A 2 TSRKKVLLKVIILGDSGVGKTSLMNQYVNKKFSN----QYKATI--------GADFLTKEVMVDDRL---VTMQIWDT-A 65 (207) T ss_dssp -----CEEEEEEECCTTSSHHHHHHHHHHSCCCS----SCCCCC--------SEEEEEEEEESSSCE---EEEEEEEE-C T ss_pred CCCCCEEEEEEEEECCCCCHHHHHHHHHCCCCCC----CCCCCE--------EEEEEEEEEEECCCE---EEEEEECC-C T ss_conf 7666446899998079987899999986480167----525630--------357899997512761---55565327-7 Q ss_pred CCHHHHHHHHHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCC Q ss_conf 871123200110581012003-3433300003136899999999999999850695888999999999862268876777 Q Fun_An_XP_0013 120 PSLSFAPLLKPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSS 198 (523) Q Consensus 120 ~d~~~~~LLk~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~ 198 (523) |...+ ..+.+..++.. .++|+.|-+.+.++-. +.+|..-++..+...... T Consensus 66 g~~~~-----~~~~~~~~~~~~~~i~v~d~~~~~s~~~-~~~~~~~~~~~~~~~~~~----------------------- 116 (207) T 1vg8_A 66 GQERF-----QSLGVAFYRGADCCVLVFDVTAPNTFKT-LDSWRDEFLIQASPRDPE----------------------- 116 (207) T ss_dssp SSGGG-----SCSCCGGGTTCSEEEEEEETTCHHHHHT-HHHHHHHHHHHHCCSSGG----------------------- T ss_pred CCCCC-----CCCCCCCCCCCCEEEEEEEEECCHHHCC-CHHHHHHHHHHHHHCCCC----------------------- T ss_conf 64311-----2255310024211334443200001002-034689999986211678----------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCC Q ss_conf 77677776645321368887532678950799961875567888635885568999999999999871841255212332 Q Fun_An_XP_0013 199 GGAQGFTSSAGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLA 278 (523) Q Consensus 199 ~~~~~~~~s~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~ 278 (523) ++|+++|.+|+| +.......++...|.+. .+++..|.+|++.. T Consensus 117 --------------------------~~piiiV~nK~D----l~~~~~~~~~~~~~~~~-------~~~~~~~~~Sa~~~ 159 (207) T 1vg8_A 117 --------------------------NFPFVVLGNKID----LENRQVATKRAQAWCYS-------KNNIPYFETSAKEA 159 (207) T ss_dssp --------------------------GSCEEEEEECTT----SSCCCSCHHHHHHHHHH-------TTSCCEEECBTTTT T ss_pred --------------------------CCEEEEEECCCC----CCHHHHHHHHHHHHHHH-------HCCCCEEEEECCCC T ss_conf --------------------------841899844645----10111048999999998-------53894477513567 Q ss_pred CCHHHHHH Q ss_conf 10345655 Q Fun_An_XP_0013 279 NSLQSLIH 286 (523) Q Consensus 279 ~nl~~Llh 286 (523) .+...|.. T Consensus 160 ~gi~~lf~ 167 (207) T 1vg8_A 160 INVEQAFQ 167 (207) T ss_dssp BSHHHHHH T ss_pred CCHHHHHH T ss_conf 78889999 No 74 >1gwn_A RHO-related GTP-binding protein RHOE; inactive GTPase, signal transduction; HET: GTP; 2.1A {Mus musculus} SCOP: c.37.1.8 Probab=97.66 E-value=0.0013 Score=45.85 Aligned_columns=163 Identities=17% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|..+.||++|+..+......... .|-+...|-..+ ..++....+.+|-. .|...+..+. T Consensus 31 I~liG~~~vGKTSli~~l~~~~~~~~~--------~~ti~~~~~~~~--------~~~~~~~~i~i~Dt-~G~~~~~~~~ 93 (205) T 1gwn_A 31 IVVVGDSQCGKTALLHVFAKDCFPENY--------VPTVFENYTASF--------EIDTQRIELSLWDT-SGSPYYDNVR 93 (205) T ss_dssp EEEEESTTSSHHHHHHHHHHSCCCSSC--------CCCSEEEEEEEE--------ESSSSEEEEEEEEE-CCSGGGTTTG T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCC--------CCEEEEEEEEEE--------EECCEEEEEEEECC-CCCCCCCCCC T ss_conf 999816998789999998628447653--------430244589999--------86347886543124-2223443234 Q ss_pred HHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC Q ss_conf 11058101200334333000031368999999999999998506958889999999998622688767777767777664 Q Fun_An_XP_0013 129 KPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSSA 208 (523) Q Consensus 129 k~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s~ 208 (523) +..+. .-..++++.|.+.+.+|-.-++.|...++.... T Consensus 94 ~~~~~----~ad~~ilv~dv~~~~Sf~~~~~~~~~~i~~~~~-------------------------------------- 131 (205) T 1gwn_A 94 PLSYP----DSDAVLICFDISRPETLDSVLKKWKGEIQEFCP-------------------------------------- 131 (205) T ss_dssp GGGCT----TCSEEEEEEETTCHHHHHHHHHTHHHHHHHHCT-------------------------------------- T ss_pred CCCCC----CCEEEEEEEECCCHHHHHHHHHHHHHHHHHHCC-------------------------------------- T ss_conf 10012----201124576325466777888888999986357-------------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHH-HHHHHHHHHHHCCEEEE-ECCCCCCC-HHHHH Q ss_conf 53213688875326789507999618755678886358855689999-99999999871841255-21233210-34565 Q Fun_An_XP_0013 209 GPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFI-LQFMRTLLLKHGASLIY-TTPFLANS-LQSLI 285 (523) Q Consensus 209 ~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfI-qQ~lRt~cLqYGAsLiY-TS~~~~~n-l~~Ll 285 (523) .+|+++|.+|+|..+......+...+.-..| .+..+.+|-++|+-.++ ||.+...| ...+. T Consensus 132 ----------------~~piiiVgNK~Dl~~~~~~~~~~~~~~~~~I~~~~~~~~a~~~~~~~~~E~SA~~~~n~i~evF 195 (205) T 1gwn_A 132 ----------------NTKMLLVGCKSDLRTDVSTLVELSNHRQTPVSYDQGANMAKQIGAATYIECSALQSENSVRDIF 195 (205) T ss_dssp ----------------TCEEEEEEECGGGGGCHHHHHHHHTTTCCCCCHHHHHHHHHHHTCSEEEECCTTTCHHHHHHHH T ss_pred ----------------CCCEEEEECCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHH T ss_conf ----------------8727998605576532025788875212356889999999971895389975147871589999 Q ss_pred H Q ss_conf 5 Q Fun_An_XP_0013 286 H 286 (523) Q Consensus 286 h 286 (523) + T Consensus 196 ~ 196 (205) T 1gwn_A 196 H 196 (205) T ss_dssp H T ss_pred H T ss_conf 9 No 75 >d1m7ba_ c.37.1.8 (A:) RhoE (RND3) {Mouse (Mus musculus)} Probab=97.65 E-value=0.0023 Score=44.27 Aligned_columns=163 Identities=16% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|..+.||++|+..+....... .+.- -++-.|.--..-|... -++.+|=. .|...+..+. T Consensus 5 I~iiG~~~vGKTsli~~~~~~~f~~----~~~~----------t~~~~~~~~~~~~~~~--~~~~i~D~-~g~~~~~~~~ 67 (179) T d1m7ba_ 5 IVVVGDSQCGKTALLHVFAKDCFPE----NYVP----------TVFENYTASFEIDTQR--IELSLWDT-SGSPYYDNVR 67 (179) T ss_dssp EEEEESTTSSHHHHHHHHHHSCCCS----SCCC----------CSEEEEEEEEECSSCE--EEEEEEEE-CCSGGGTTTG T ss_pred EEEEECCCCCHHHHHHHHHCCCCCC----CCCC----------EEEEEEEEEEECCCCC--CEEEEECC-CCCCCCCHHH T ss_conf 9997069987899999986282366----6343----------3676213432013311--02686114-4321000000 Q ss_pred HHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC Q ss_conf 11058101200334333000031368999999999999998506958889999999998622688767777767777664 Q Fun_An_XP_0013 129 KPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSSA 208 (523) Q Consensus 129 k~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s~ 208 (523) +..... -..+||+.|.+.++++-.-++.|...++.. T Consensus 68 ~~~~~~----~d~~iivydv~~~~Sf~~i~~~~~~~~~~~---------------------------------------- 103 (179) T d1m7ba_ 68 PLSYPD----SDAVLICFDISRPETLDSVLKKWKGEIQEF---------------------------------------- 103 (179) T ss_dssp GGGCTT----CSEEEEEEETTCHHHHHHHHHTHHHHHHHH---------------------------------------- T ss_pred HHHHCC----CCEEEEEEECCCCHHHHHHHHHHHHHHHHH---------------------------------------- T ss_conf 566327----865799980686035788988777777640---------------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHH-HHHHHHHHCCEEEE-ECCCCCCC-HHHHH Q ss_conf 53213688875326789507999618755678886358855689999999-99999871841255-21233210-34565 Q Fun_An_XP_0013 209 GPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQF-MRTLLLKHGASLIY-TTPFLANS-LQSLI 285 (523) Q Consensus 209 ~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~-lRt~cLqYGAsLiY-TS~~~~~n-l~~Ll 285 (523) .-.+|++||++|+|.-+......+...+.--.|.+- .+.+|-++||..+| ||++...| .+.+. T Consensus 104 --------------~~~~piilvgnK~DL~~~~~~~~~~~~~~~~~Vs~~e~~~la~~~~~~~y~E~SA~t~~n~v~~~F 169 (179) T d1m7ba_ 104 --------------CPNTKMLLVGCKSDLRTDVSTLVELSNHRQTPVSYDQGANMAKQIGAATYIECSALQSENSVRDIF 169 (179) T ss_dssp --------------CTTCEEEEEEECGGGGGCHHHHHHHHTTTCCCCCHHHHHHHHHHHTCSEEEECBTTTBHHHHHHHH T ss_pred --------------CCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHH T ss_conf --------------267415787526663210345665443037658989999999970895289875036884089999 Q ss_pred H Q ss_conf 5 Q Fun_An_XP_0013 286 H 286 (523) Q Consensus 286 h 286 (523) + T Consensus 170 ~ 170 (179) T d1m7ba_ 170 H 170 (179) T ss_dssp H T ss_pred H T ss_conf 9 No 76 >d1moza_ c.37.1.8 (A:) ADP-ribosylation factor {Baker's yeast (Saccharomyces cerevisiae), ARL1} Probab=97.65 E-value=0.0012 Score=46.17 Aligned_columns=171 Identities=18% Q ss_pred HHHHHHHHHHHHHCCCCCEEEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCC Q ss_conf 37789888766404884204788647798732123233111124556631225656744443342022331000677455 Q Fun_An_XP_0013 29 NIWSSMLDSVANGKRLPEKNLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDT 108 (523) Q Consensus 29 nLWssiL~~vss~~rlpsKnilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~ 108 (523) ||.|.|++..-+.++-. .|+++|..+.||+||+..+.+.......+.. +..+..+...+ T Consensus 2 ~~~~~~~~~~~~~~k~~--ki~viG~~~~GKSSLi~~l~~~~~~~~~~~~-------------~~~~~~~~~~~------ 60 (182) T d1moza_ 2 NIFSSMFDKLWGSNKEL--RILILGLDGAGKTTILYRLQIGEVVTTKPTI-------------GFNVETLSYKN------ 60 (182) T ss_dssp HHHHHHHGGGTTCSSCE--EEEEEEETTSSHHHHHHHTCCSEEEEECSST-------------TCCEEEEEETT------ T ss_pred HHHHHHHHHHCCCCCEE--EEEEEECCCCCHHHHHHHHHHCCCCCCCCCC-------------CCEEEEEEECC------ T ss_conf 26889999743888337--9999817998799999998512333444324-------------40488874055------ Q ss_pred CCEEEEEEECCCCHHHHHHHHHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH Q ss_conf 11016787178871123200110581012003343330000313689999999999999985069588899999999986 Q Fun_An_XP_0013 109 LARVSAYLLSEPSLSFAPLLKPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWR 188 (523) Q Consensus 109 ~aR~svyiL~d~d~~~~~LLk~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~ 188 (523) .++..|-. .+...+....+..... ...++++.|.++++++.+-.+.|..+++.. T Consensus 61 -~~~~~~d~-~~~~~~~~~~~~~~~~----~~~~i~v~d~~~~~s~~~~~~~~~~~~~~~-------------------- 114 (182) T d1moza_ 61 -LKLNVWDL-GGQTSIRPYWRCYYAD----TAAVIFVVDSTDKDRMSTASKELHLMLQEE-------------------- 114 (182) T ss_dssp -EEEEEEEE-C----CCTTGGGTTTT----EEEEEEEEETTCTTTHHHHHHHHHHHTTSS-------------------- T ss_pred -EEEEECCC-CHHHHHHHHHHHHHHC----CCEEEEEEEECCCCCHHHHHHHHHHHHHHC-------------------- T ss_conf -57874043-0134433455554202----332467774025787778999999998501-------------------- Q ss_pred HCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCC Q ss_conf 22688767777767777664532136888753267895079996187556788863588556899999999999987184 Q Fun_An_XP_0013 189 DRKRGMDSSSGGAQGFTSSAGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGA 268 (523) Q Consensus 189 e~~~~~~~~~~~~~~~~~s~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGA 268 (523) ....+|++||++|+|... ....-+...+.-...|-.+.. T Consensus 115 ---------------------------------~~~~~piiiv~nK~Dl~~--------~~~~~~i~~~~~~~~~~~~~~ 153 (182) T d1moza_ 115 ---------------------------------ELQDAALLVFANKQDQPG--------ALSASEVSKELNLVELKDRSW 153 (182) T ss_dssp ---------------------------------TTSSCEEEEEEECTTSTT--------CCCHHHHHHHTTTTTCCSSCE T ss_pred ---------------------------------CCCCEEEEEEEECCCCCC--------CCCHHHHHHHHHHHHHHCCCC T ss_conf ---------------------------------447505899973358644--------479889999988875411793 Q ss_pred EEEEECCCCCCCHHHHHHH Q ss_conf 1255212332103456553 Q Fun_An_XP_0013 269 SLIYTTPFLANSLQSLIHS 287 (523) Q Consensus 269 sLiYTS~~~~~nl~~Llh~ 287 (523) ..|.||++.-.+++.++.. T Consensus 154 ~~~~~Sa~tg~gi~e~~~~ 172 (182) T d1moza_ 154 SIVASSAIKGEGITEGLDW 172 (182) T ss_dssp EEEEEBGGGTBTHHHHHHH T ss_pred EEEEEECCCCCCHHHHHHH T ss_conf 5899853679888999999 No 77 >cd04110 Rab35 Rab35 subfamily. Rab35 is one of several Rab proteins to be found to participate in the regulation of osteoclast cells in rats. In addition, Rab35 has been identified as a protein that interacts with nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) in human cells. Overexpression of NPM-ALK is a key oncogenic event in some anaplastic large-cell lymphomas; since Rab35 interacts with N|PM-ALK, it may provide a target for cancer treatments. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site at the C-terminus, with sequence motifs CC, CXC, or CCX. Lipid binding is Probab=97.65 E-value=0.0057 Score=41.74 Aligned_columns=151 Identities=17% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|+.+.||++|+-.+....-.. .+.--- |..|.-..|.-+++. .++.+|=.+..+-+ T Consensus 9 vv~iGd~~VGKTsli~r~~~~~F~~----~y~~Ti--------g~~~~~k~v~i~~~~---~~l~iwDtaGqe~~----- 68 (199) T cd04110 9 LLIIGDSGVGKSSLLLRFADNTFSG----SYITTI--------GVDFKIRTVEINGER---VKLQIWDTAGQERF----- 68 (199) T ss_pred EEEEECCCCCHHHHHHHHHCCEECC----CCCCCE--------EEEEEEEEEEECCEE---EEEEEEECCCCCHH----- T ss_conf 9998269843899998876180076----646511--------223578889985839---99999866997035----- Q ss_pred HHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 110581012003-3433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 129 KPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 129 k~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) ..+.+..++++ .+|||-|.+.+.+| +.|.+|+..++.... T Consensus 69 -~~l~~~y~~~a~~~ilVydit~~~Sf-~~i~~w~~~i~~~~~------------------------------------- 109 (199) T cd04110 69 -RTITSTYYRGTHGVIVVYDVTNGESF-VNVKRWLQEIEQNCD------------------------------------- 109 (199) T ss_pred -HHHHHHHCCCCCEEEEEEECCCHHHH-HHHHHHHHHHHHHCC------------------------------------- T ss_conf -67767650389879999877997799-999999999985125------------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHH Q ss_conf 4532136888753267895079996187556788863588556899999999999987184125521233210345655 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIH 286 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh 286 (523) -+|+++|..|+| |+..+-...|+.. .+|-++|+..|.||++...|...+.+ T Consensus 110 -----------------~~~~iLVGNK~D----l~~~r~v~~ee~~-------~~a~~~~~~f~EtSAktg~nV~e~F~ 160 (199) T cd04110 110 -----------------DVCKVLVGNKND----DPERKVVETEDAY-------KFAGQMGISLFETSAKENINVEEMFN 160 (199) T ss_pred -----------------CCCEEEEEECCC----CHHHCCCCHHHHH-------HHHHHCCCCEEEEECCCCCCHHHHHH T ss_conf -----------------673699840336----3112265689999-------99996699599997158988889999 No 78 >1c1y_A RAS-related protein RAP-1A; GTP-binding proteins, protein-protein complex, effectors; HET: GTP; 1.90A {Homo sapiens} SCOP: c.37.1.8 Probab=97.65 E-value=0.0093 Score=40.35 Aligned_columns=156 Identities=15% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|..+.||+||+..+....... .... ..+..|.-...-+... ..+..|-. .|.-.+..+. T Consensus 6 i~iiG~~~vGKTsli~~~~~~~~~~----~~~~----------~~~~~~~~~~~~~~~~--~~~~~~d~-~g~e~~~~~~ 68 (167) T 1c1y_A 6 LVVLGSGGVGKSALTVQFVQGIFVE----KYDP----------TIEDSYRKQVEVDCQQ--CMLEILDT-AGTEQFTAMR 68 (167) T ss_dssp EEEECSTTSSHHHHHHHHHHCCCCC----SCCC----------CSEEEEEEEEESSSCE--EEEEEEEE-CSSCSSTTHH T ss_pred EEEEECCCCCHHHHHHHHHCCCCCC----CCCC----------CCCCCEEEEEEECCEE--EEEEEEEC-CCCCCCHHHH T ss_conf 8988079987899999986283365----5465----------2200111211225746--88776403-4633101333 Q ss_pred HHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC Q ss_conf 11058101200334333000031368999999999999998506958889999999998622688767777767777664 Q Fun_An_XP_0013 129 KPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSSA 208 (523) Q Consensus 129 k~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s~ 208 (523) +.....-. .++++.|.+.|.++ +.+..|..-+..+... T Consensus 69 ~~~~~~~~----~~i~v~d~~~~~s~-~~~~~~~~~~~~~~~~------------------------------------- 106 (167) T 1c1y_A 69 DLYMKNGQ----GFALVYSITAQSTF-NDLQDLREQILRVKDT------------------------------------- 106 (167) T ss_dssp HHHHHHCS----EEEEEEETTCHHHH-HTHHHHHHHHHHHHCC------------------------------------- T ss_pred HHHHHHCC----CEEEEEECCCCHHH-HHHHHHHHHHHHHCCC------------------------------------- T ss_conf 44531113----42788415670014-4556664333332057------------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH-CCEEEEECCCCCCCHHHHHHH Q ss_conf 5321368887532678950799961875567888635885568999999999999871-841255212332103456553 Q Fun_An_XP_0013 209 GPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKH-GASLIYTTPFLANSLQSLIHS 287 (523) Q Consensus 209 ~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqY-GAsLiYTS~~~~~nl~~Llh~ 287 (523) -.+|+++|++|+| |..++....++- +.++.+| +...|.||.+...+...|... T Consensus 107 ---------------~~~~iilv~nK~D----l~~~~~v~~~~~-------~~~~~~~~~~~~~e~Sak~~~~i~elf~~ 160 (167) T 1c1y_A 107 ---------------EDVPMILVGNKCD----LEDERVVGKEQG-------QNLARQWCNCAFLESSAKSKINVNEIFYD 160 (167) T ss_dssp ---------------SCCCEEEEEECTT----CGGGCCSCHHHH-------HHHHHHTTSCEEEECBTTTTBSHHHHHHH T ss_pred ---------------CCCEEEEEECCCC----CHHHHCCCHHHH-------HHHHHHHCCCEEEEEECCCCCCHHHHHHH T ss_conf ---------------8850899822654----001214667899-------99999835971899861688687899999 Q ss_pred HC Q ss_conf 22 Q Fun_An_XP_0013 288 SL 289 (523) Q Consensus 288 ~l 289 (523) .. T Consensus 161 i~ 162 (167) T 1c1y_A 161 LV 162 (167) T ss_dssp HH T ss_pred HH T ss_conf 99 No 79 >cd04119 RJL RJL (RabJ-Like) subfamily. RJLs are found in many protists and as chimeras with C-terminal DNAJ domains in deuterostome metazoa. They are not found in plants, fungi, and protostome metazoa, suggesting a horizontal gene transfer between protists and deuterostome metazoa. RJLs lack any known membrane targeting signal and contain a degenerate phosphate/magnesium-binding 3 (PM3) motif, suggesting an impaired ability to hydrolyze GTP. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Probab=97.64 E-value=0.005 Score=42.12 Aligned_columns=156 Identities=16% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|+.+.||++|+..+...+-.. ++..-- +.+| .++.-..++...++.+|=. .|...|..+. T Consensus 3 ivivGd~~vGKTsli~r~~~~~f~~----~y~~Ti--------g~~~---~~k~i~~~~~~~~l~iwDt-aG~e~~~~~~ 66 (168) T cd04119 3 VISMGNSGVGKSCIIKRYCEGRFVS----KYLPTI--------GIDY---GVKKVSVRNKEVRVNFFDL-SGHPEYLEVR 66 (168) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCC----CCCCCE--------EEEE---EEEEEEECCEEEEEEEEEC-CCCHHHHHHH T ss_conf 8998079854899998877180166----536503--------5555---5678888794899998606-8981257887 Q ss_pred HHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC Q ss_conf 11058101200334333000031368999999999999998506958889999999998622688767777767777664 Q Fun_An_XP_0013 129 KPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSSA 208 (523) Q Consensus 129 k~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s~ 208 (523) +..+.--+ .++++-|.+++.++-. +.+|+.-++.++.....- T Consensus 67 ~~~~~~a~----~~ilvydit~~~Sf~~-i~~w~~~~~~~~~~~~~~--------------------------------- 108 (168) T cd04119 67 NEFYKDTQ----GVLLVYDVTDRQSFEA-LDSWLKEMKQEGGPHGNM--------------------------------- 108 (168) T ss_pred HHHHCCCC----EEEEEEECCCHHHHHH-HHHHHHHHHHHCCCCCCC--------------------------------- T ss_conf 88723999----3899985699778999-999999999860555666--------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHH Q ss_conf 5321368887532678950799961875567888635885568999999999999871841255212332103456 Q Fun_An_XP_0013 209 GPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSL 284 (523) Q Consensus 209 ~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~L 284 (523) -.+|+++|-+|+| |...+.-..++ .+.+|-++|+..|-||++...|...+ T Consensus 109 ---------------~~~~iilvGNK~D----l~~~r~V~~~~-------~~~~a~~~~~~~~E~SAk~~~nV~e~ 158 (168) T cd04119 109 ---------------ENIVVVVCANKID----LTKHRAVSEDE-------GRLWAESKGFKYFETSACTGEGVNEM 158 (168) T ss_pred ---------------CCCEEEEEECCCC----CCCCCCCCHHH-------HHHHHHHCCCEEEEEECCCCCCHHHH T ss_conf ---------------8747999705323----32357679899-------99999964991999971589787899 No 80 >e2a5ja1 c.37.1.8 (A:9-181) Rab2b {Human (Homo sapiens) [TaxID:9606]} SCOP: u1z0aa1 u1z0ad_ u1z0ab_ Probab=97.64 E-value=0.0027 Score=43.85 Aligned_columns=156 Identities=17% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+|+|..+.||++|+..+.+..... +... ..+..+....-.-.+.. .++.+|-. .|...+..+. T Consensus 6 V~ivG~~~vGKTsLi~~~~~~~~~~----~~~~----------t~~~~~~~~~~~~~~~~-~~l~i~d~-~g~~~~~~~~ 69 (173) T e2a5ja1 6 YIIIGDTGVGKSCLLLQFTDKRFQP----VHDL----------TIGVEFGARMVNIDGKQ-IKLQIWDT-AGQESFRSIT 69 (173) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCC----CCCC----------EEEEECCCCCCEECCCE-EEEEEEEC-CCCCCCCCHH T ss_conf 9998369977999999986483466----6341----------35520010111015852-79998614-7853110000 Q ss_pred HHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC Q ss_conf 11058101200334333000031368999999999999998506958889999999998622688767777767777664 Q Fun_An_XP_0013 129 KPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSSA 208 (523) Q Consensus 129 k~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s~ 208 (523) +..+ -....++++.|.+++.++ +.+.+|+.-+.....+ T Consensus 70 ~~~~----~~~d~~i~v~d~~~~~s~-~~~~~~~~~i~~~~~~------------------------------------- 107 (173) T e2a5ja1 70 RSYY----RGAAGALLVYDITRRETF-NHLTSWLEDARQHSSS------------------------------------- 107 (173) T ss_pred HHHH----CCCCEEEEEEECCCHHHH-HHHHHHHHHHHHHCCC------------------------------------- T ss_conf 5550----489768999742651467-8988889998852167------------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHH Q ss_conf 53213688875326789507999618755678886358855689999999999998718412552123321034565532 Q Fun_An_XP_0013 209 GPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIHSS 288 (523) Q Consensus 209 ~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh~~ 288 (523) ..|++||++|+|. +++-..-++.++.+|-++|...|.||++...+...+.+.. T Consensus 108 ----------------~~p~iivgnK~Dl-----------~~~~~v~~~~~~~~~~~~~~~~~e~Saktg~gv~e~F~~l 160 (173) T e2a5ja1 108 ----------------NMVIMLIGNKSDL-----------ESRRDVKREEGEAFAREHGLIFMETSAKTACNVEEAFINT 160 (173) T ss_pred ----------------CCEEEEEECCCCC-----------HHHCCCCHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHH T ss_conf ----------------6123221011244-----------1010320889999999649849998516898888999999 Q ss_pred C Q ss_conf 2 Q Fun_An_XP_0013 289 L 289 (523) Q Consensus 289 l 289 (523) . T Consensus 161 ~ 161 (173) T e2a5ja1 161 A 161 (173) T ss_pred H T ss_conf 9 No 81 >d3raba_ c.37.1.8 (A:) Rab3a {Rat (Rattus norvegicus)} Probab=97.64 E-value=0.014 Score=39.21 Aligned_columns=156 Identities=17% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|..+.||+||+..+.+..... ....+- +..+.+..+...+.. ..+..|.. .+...+..+- T Consensus 8 I~ivG~~~vGKSsLi~~l~~~~~~~----~~~~~~--------~~~~~~~~~~~~~~~---~~~~i~~~-~g~~~~~~~~ 71 (169) T d3raba_ 8 ILIIGNSSVGKTSFLFRYADDSFTP----AFVSTV--------GIDFKVKTIYRNDKR---IKLQIWDT-AGQERYRTIT 71 (169) T ss_dssp EEEECSTTSSHHHHHHHHHHSCCCS----SCCCCC--------SEEEEEEEEEETTEE---EEEEEEEE-CCSGGGHHHH T ss_pred EEEEECCCCCHHHHHHHHHCCEECC----CCCCCC--------CCCEEEEEEEECCCE---EEEEEECC-CCCCHHHHHH T ss_conf 8998369987999999985680034----521123--------421136777645820---36787216-7630233454 Q ss_pred HHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC Q ss_conf 11058101200334333000031368999999999999998506958889999999998622688767777767777664 Q Fun_An_XP_0013 129 KPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSSA 208 (523) Q Consensus 129 k~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s~ 208 (523) +........ ++++.|.+.+.+ .+.++.|...++... T Consensus 72 ~~~~~~~~~----~i~v~d~~~~~s-~~~~~~~~~~i~~~~--------------------------------------- 107 (169) T d3raba_ 72 TAYYRGAMG----FILMYDITNEES-FNAVQDWSTQIKTYS--------------------------------------- 107 (169) T ss_dssp HTTTTTCCE----EEEEEETTCHHH-HHTHHHHHHHHHHHC--------------------------------------- T ss_pred HHHHHHHEE----EEEEEECCCCCH-HHHHHHHHHHHHHCC--------------------------------------- T ss_conf 443211101----133320222210-345566655532101--------------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHH Q ss_conf 53213688875326789507999618755678886358855689999999999998718412552123321034565532 Q Fun_An_XP_0013 209 GPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIHSS 288 (523) Q Consensus 209 ~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh~~ 288 (523) ...+|+++|++|+| +.++.....++ ++.+|-++|+..|.||.+...+...+.... T Consensus 108 --------------~~~~pii~v~nK~D----~~~~~~~~~~~-------~~~~~~~~~~~~~e~Sa~~~~gi~e~f~~l 162 (169) T d3raba_ 108 --------------WDNAQVLLVGNKCD----MEDERVVSSER-------GRQLADHLGFEFFEASAKDNINVKQTFERL 162 (169) T ss_dssp --------------CSCCEEEEEEECTT----CGGGCCSCHHH-------HHHHHHHHTCEEEECBTTTTBSHHHHHHHH T ss_pred --------------CCCCEEEEHHHHCC----HHHHCCCCHHH-------HHHHHHHCCCEEEEEECCCCCCHHHHHHHH T ss_conf --------------37732685012124----13300442899-------999999649808998626898888999999 Q ss_pred C Q ss_conf 2 Q Fun_An_XP_0013 289 L 289 (523) Q Consensus 289 l 289 (523) + T Consensus 163 ~ 163 (169) T d3raba_ 163 V 163 (169) T ss_dssp H T ss_pred H T ss_conf 9 No 82 >2ce2_X GTPase HRAS; guanine nucleotide binding protein, fluorescence, membrane, signaling protein, disease mutation, golgi stack, GTP- binding; HET: GDP XY2; 1.0A {Homo sapiens} Probab=97.63 E-value=0.0075 Score=40.95 Aligned_columns=160 Identities=16% Q ss_pred CCCEEEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHH Q ss_conf 84204788647798732123233111124556631225656744443342022331000677455110167871788711 Q Fun_An_XP_0013 44 LPEKNLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLS 123 (523) Q Consensus 44 lpsKnilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~ 123 (523) +++=.|+++|..+.||+|||..+.+..... .... ..+..|.....-|... .++.+|-. .|.-. T Consensus 1 m~e~Ki~iiG~~~vGKTsll~~~~~~~~~~----~~~~----------t~~~~~~~~~~~~~~~--~~~~~~d~-~g~~~ 63 (166) T 2ce2_X 1 MTEYKLVVVGAGGVGKSALTIQLIQNHFVD----ECDP----------TIEDSYRKQVVIDGET--CLLDILDT-AGQEE 63 (166) T ss_dssp CCEEEEEEEESTTSSHHHHHHHHHHSSCCS----CCCT----------TCCEEEEEEEEETTEE--EEEEEEEC-CCCSS T ss_pred CCCEEEEEEECCCCCHHHHHHHHHCCCCCC----CCCC----------CEEEEEEEEEEECCEE--EEEEEECC-CCCCC T ss_conf 982368998079987899999986383255----5343----------0000256778643435--53124404-67643 Q ss_pred HHHHHHHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCC Q ss_conf 23200110581012003343330000313689999999999999985069588899999999986226887677777677 Q Fun_An_XP_0013 124 FAPLLKPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQG 203 (523) Q Consensus 124 ~~~LLk~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~ 203 (523) +..+.+..+..-.. ++++.|.+++.++-+ +.+|..-++...... T Consensus 64 ~~~~~~~~~~~~~~----~i~v~d~~~~~s~~~-~~~~~~~i~~~~~~~------------------------------- 107 (166) T 2ce2_X 64 YSAMRDQYMRTGEG----FLCVFAINNTKSFED-IHQYREQIKRVKDSD------------------------------- 107 (166) T ss_dssp CCHHHHHHHHHCSE----EEEEEETTCHHHHHH-HHHHHHHHHHHHTCS------------------------------- T ss_pred CCCCCCHHHHHHEE----EEEEEECCCHHHHHH-HHHHHHHHHHHCCCC------------------------------- T ss_conf 32111001110001----110121341122344-445665555302789------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHH Q ss_conf 77664532136888753267895079996187556788863588556899999999999987184125521233210345 Q Fun_An_XP_0013 204 FTSSAGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQS 283 (523) Q Consensus 204 ~~~s~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~ 283 (523) .+|+++|.+|+| ..++...+++. +.++.++|...|.||.+...+... T Consensus 108 ---------------------~~piiiv~nK~D-----l~~~~~~~~~~-------~~~~~~~~~~~~e~Sak~~~gi~e 154 (166) T 2ce2_X 108 ---------------------DVPMVLVGNKSD-----LAARTVESRQA-------QDLARSYGIPYIETSAKTRQGVED 154 (166) T ss_dssp ---------------------CCCEEEEEECTT-----CSCCCSCHHHH-------HHHHHHHTCCEEEECTTTCTTHHH T ss_pred ---------------------CCEEEEEECCCC-----HHHCCCHHHHH-------HHHHHHCCCEEEEEECCCCCCHHH T ss_conf ---------------------848999502545-----01103407899-------999996498189986268868789 Q ss_pred HHHHHC Q ss_conf 655322 Q Fun_An_XP_0013 284 LIHSSL 289 (523) Q Consensus 284 Llh~~l 289 (523) +....+ T Consensus 155 ~f~~i~ 160 (166) T 2ce2_X 155 AFYTLV 160 (166) T ss_dssp HHHHHH T ss_pred HHHHHH T ss_conf 999999 No 83 >1yzq_A Small GTP binding protein RAB6 isoform; RAB GTPase, vesicular trafficking, protein transport; HET: GNP; 1.78A {Homo sapiens} SCOP: c.37.1.8 Probab=97.63 E-value=0.0083 Score=40.67 Aligned_columns=154 Identities=18% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+|+|..+.||++|+..+....... +....- +..|....+...+.. ..+..|-. .+...+..+. T Consensus 9 I~iiG~~~vGKTsli~~~~~~~~~~----~~~~t~--------~~~~~~~~~~~~~~~---~~l~~~d~-~g~~~~~~~~ 72 (170) T 1yzq_A 9 LVFLGEQSVGKTSLITRFMYDSFDN----TYQATI--------GIDFLSKTMYLEDRT---IRLQLWDT-AGQERFRSLI 72 (170) T ss_dssp EEEEESTTSSHHHHHHHHHHSCCCS----SCCCCC--------SEEEEEEEEECSSCE---EEEEEEEE-CCSGGGGGGH T ss_pred EEEEECCCCCHHHHHHHHHCCCCCC----CCCCCE--------EEEEEEEEEECCCCE---EEEEECCC-CCCCHHCCCC T ss_conf 9998079977899999986482455----544210--------003433576115846---76643146-5521001233 Q ss_pred HHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC Q ss_conf 11058101200334333000031368999999999999998506958889999999998622688767777767777664 Q Fun_An_XP_0013 129 KPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSSA 208 (523) Q Consensus 129 k~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s~ 208 (523) +..+. .-..++++.|.+.|+++. .+..|..-++.+... T Consensus 73 ~~~~~----~~~~~i~v~d~~~~~s~~-~i~~~~~~~~~~~~~------------------------------------- 110 (170) T 1yzq_A 73 PSYIR----DSAAAVVVYDITNVNSFQ-QTTKWIDDVRTERGS------------------------------------- 110 (170) T ss_dssp HHHHT----TCSEEEEEEETTCHHHHH-THHHHHHHHHHHHTT------------------------------------- T ss_pred HHHHC----CCEEEEEEECCCCHHHHH-HHHHHHHHHHHHCCC------------------------------------- T ss_conf 00100----011346643156602455-555655433221147------------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHH Q ss_conf 5321368887532678950799961875567888635885568999999999999871841255212332103456553 Q Fun_An_XP_0013 209 GPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIHS 287 (523) Q Consensus 209 ~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh~ 287 (523) .+|+++|++|+|..+.-+. ..+.++.++-+++...|-+|++...+...|... T Consensus 111 ----------------~~p~ilV~nK~Dl~~~~~~-----------~~~~~~~~~~~~~~~~~evSa~~~~gv~~~f~~ 162 (170) T 1yzq_A 111 ----------------DVIIMLVGNKTDLADKRQV-----------SIEEGERKAKELNVMFIETSAKAGYNVKQLFRR 162 (170) T ss_dssp ----------------SSEEEEEEECTTCGGGCCS-----------CHHHHHHHHHHTTCEEEECCTTTCTTHHHHHHH T ss_pred ----------------CCEEEEEECCCCHHHHHHH-----------HHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHH T ss_conf ----------------8417998625581233324-----------689999999964981899862689788899999 No 84 >1i2m_A RAN, GTP-binding nuclear protein RAN; beta-propeller, G fold or GTPase fold; 1.76A {Homo sapiens} SCOP: c.37.1.8 Probab=97.63 E-value=0.0024 Score=44.18 Aligned_columns=150 Identities=12% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|..+.||++|+..+....... .+...- +..|....+..++.. -++.+|=. .|...+..+. T Consensus 13 IvivG~~~vGKTsLi~~~~~~~f~~----~~~~Ti--------~~d~~~~~~~~~~~~---~~l~i~Dt-~g~~~~~~~~ 76 (216) T 1i2m_A 13 LVLVGDGGTGKTTFVKRHLTGEFEK----KYVATL--------GVEVHPLVFHTNRGP---IKFNVWDT-AGQEKFGGLR 76 (216) T ss_dssp EEEEECTTSSHHHHHHTTC-----C----CEEEET--------TEEEEEEEECBTTCC---EEEEEEEC-TTHHHHSSCG T ss_pred EEEEECCCCCHHHHHHHHHCCCCCC----CCCCEE--------EEEEEEEEECCCCCC---CCEEECCC-CCCHHHHHCC T ss_conf 9988079987999999986383266----524404--------566655430368852---11122243-1101221010 Q ss_pred HHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC Q ss_conf 11058101200334333000031368999999999999998506958889999999998622688767777767777664 Q Fun_An_XP_0013 129 KPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSSA 208 (523) Q Consensus 129 k~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s~ 208 (523) +..+..-. .++++.|.+++.+| +.+.+|+.-++....+. T Consensus 77 ~~~~~~~~----~~i~v~d~~~~~Sf-~~i~~~~~~~~~~~~~~------------------------------------ 115 (216) T 1i2m_A 77 DGYYIQAQ----CAIIMFDVTSRVTY-KNVPNWHRDLVRVCENI------------------------------------ 115 (216) T ss_dssp GGGTTTCC----EEEEEEETTSGGGG-TTHHHHHHHHHHHHCSC------------------------------------ T ss_pred HHHHCCCE----EEEEECCCCCCCCH-HHHHHHHHHHHHHCCCC------------------------------------ T ss_conf 01221300----12311023311001-33567666667623882------------------------------------ Q ss_pred CCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHH Q ss_conf 532136888753267895079996187556788863588556899999999999987184125521233210345655 Q Fun_An_XP_0013 209 GPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIH 286 (523) Q Consensus 209 ~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh 286 (523) |+++|++|+| |.....-.+..- +|-++|+..|.||.+...++..+.. T Consensus 116 ------------------piilvgnK~D----l~~~~~~~~~~~---------~~~~~~~~~~e~SAk~g~gV~e~f~ 162 (216) T 1i2m_A 116 ------------------PIVLCGNKVD----IKDRKVKAKSIV---------FHRKKNLQYYDISAKSNYNFEKPFL 162 (216) T ss_dssp ------------------CEEEEEECCC----CSCSCCTTTSHH---------HHSSCSSEEEEEBTTTTBTTTHHHH T ss_pred ------------------EEEEEECCCC----CHHHHHHHHHHH---------HHHHCCCCEEEEECCCCCCHHHHHH T ss_conf ------------------5887414665----202311689999---------9996489658885167988889999 No 85 >d1m7ba_ c.37.1.8 (A:) RhoE (RND3) {Mouse (Mus musculus)} SCOP: d1gwnc_ Probab=97.62 E-value=0.0021 Score=44.56 Aligned_columns=163 Identities=17% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|..+.||++|+..+....... +... -.+-.|.....-|... -++.+|=. .|...+..+. T Consensus 5 I~iiG~~~vGKSsli~~~~~~~f~~----~~~~----------ti~~~~~~~~~~~~~~--~~~~i~Dt-~g~~~~~~~~ 67 (179) T d1m7ba_ 5 IVVVGDSQCGKTALLHVFAKDCFPE----NYVP----------TVFENYTASFEIDTQR--IELSLWDT-SGSPYYDNVR 67 (179) T ss_dssp EEEEESTTSSHHHHHHHHHHSCCCS----SCCC----------CSEEEEEEEEECSSCE--EEEEEEEE-CCSGGGTTTG T ss_pred EEEEECCCCCHHHHHHHHHCCCCCC----CCCC----------EEEEEEEEEEEECCEE--EEEEEEEC-CCCCCCCCCC T ss_conf 9997079987899999986284267----6244----------0688888865515568--99998713-5511003122 Q ss_pred HHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC Q ss_conf 11058101200334333000031368999999999999998506958889999999998622688767777767777664 Q Fun_An_XP_0013 129 KPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSSA 208 (523) Q Consensus 129 k~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s~ 208 (523) +.++.--. .++++.|++.+.++-.-++.|...++.... T Consensus 68 ~~~~~~~d----~~ilv~d~~~~~S~~~~~~~~~~~~~~~~~-------------------------------------- 105 (179) T d1m7ba_ 68 PLSYPDSD----AVLICFDISRPETLDSVLKKWKGEIQEFCP-------------------------------------- 105 (179) T ss_dssp GGGCTTCS----EEEEEEETTCHHHHHHHHHTHHHHHHHHCT-------------------------------------- T ss_pred HHHHCCCC----EEEEEEECCCHHHHHHHHHHHHHHHHHHCC-------------------------------------- T ss_conf 03331787----699998637614688885334899997348-------------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHH-HHHHHHHHCCEEEE-ECCCCCCC-HHHHH Q ss_conf 53213688875326789507999618755678886358855689999999-99999871841255-21233210-34565 Q Fun_An_XP_0013 209 GPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQF-MRTLLLKHGASLIY-TTPFLANS-LQSLI 285 (523) Q Consensus 209 ~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~-lRt~cLqYGAsLiY-TS~~~~~n-l~~Ll 285 (523) .+|+++|++|+|..+......+..++.--.|.+- .+.++-++|+-.+| ||.+...| ...+. T Consensus 106 ----------------~~piilVgnK~DL~~~~~~~~~~~~~~~~~Vs~~e~~~la~~~~~~~y~E~SA~~~~n~v~~vF 169 (179) T d1m7ba_ 106 ----------------NTKMLLVGCKSDLRTDVSTLVELSNHRQTPVSYDQGANMAKQIGAATYIECSALQSENSVRDIF 169 (179) T ss_dssp ----------------TCEEEEEEECGGGGGCHHHHHHHHTTTCCCCCHHHHHHHHHHHTCSEEEECBTTTBHHHHHHHH T ss_pred ----------------CCCEEEEECCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHH T ss_conf ----------------7504656415554431135665542037747989999999971894389874036874189999 Q ss_pred H Q ss_conf 5 Q Fun_An_XP_0013 286 H 286 (523) Q Consensus 286 h 286 (523) | T Consensus 170 ~ 170 (179) T d1m7ba_ 170 H 170 (179) T ss_dssp H T ss_pred H T ss_conf 9 No 86 >cd04124 RabL2 RabL2 subfamily. RabL2 (Rab-like2) subfamily. RabL2s are novel Rab proteins identified recently which display features that are distinct from other Rabs, and have been termed Rab-like. RabL2 contains RabL2a and RabL2b, two very similar Rab proteins that share 98% sequence identity in humans. RabL2b maps to the subtelomeric region of chromosome 22q13.3 and RabL2a maps to 2q13, a region that suggests it is also a subtelomeric gene. Both genes are believed to be expressed ubiquitously, suggesting that RabL2s are the first example of duplicated genes in human proximal subtelomeric regions that are both expressed actively. Like other Rab-like proteins, RabL2s lack a prenylation site at the C-terminus. The specific functions of RabL2a and RabL2b remain unknown. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-b Probab=97.62 E-value=0.0054 Score=41.88 Aligned_columns=146 Identities=21% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|+.+.||++|+..+...+-.. .+.. -.+-.++...- ..++....+.+|=. .|...| T Consensus 3 iiliGd~~VGKTsli~r~~~~~f~~----~~~~----------t~~~~~~~k~~-~~~~~~v~l~iwDt-~G~e~~---- 62 (161) T cd04124 3 IILLGDSAVGKSKLVERFLMDGYEP----QQLS----------TYALTLYKHNA-KFEGKTILVDFWDT-AGQERF---- 62 (161) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCC----CCCC----------CEEEEEEEEEE-EECCEEEEEEEEEC-CCCCHH---- T ss_conf 8998069944889887865386376----6235----------32567899999-99886999999745-784110---- Q ss_pred HHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 110581012003-3433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 129 KPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 129 k~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) ..+.+.-++++ .++|+-|.+.+.++ +.|.+|+.-++++-. T Consensus 63 -~~~~~~~~~~a~~~ilvfDit~~~Sf-~~l~~W~~~i~~~~~------------------------------------- 103 (161) T cd04124 63 -QTMHASYYHKAHACILVFDVTRKITY-KNLSKWYEELREYRP------------------------------------- 103 (161) T ss_pred -HHHHHHHCCCCCEEEEEEECCCHHHH-HHHHHHHHHHHHHCC------------------------------------- T ss_conf -35667430247858999866996688-999999999998469------------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHH Q ss_conf 45321368887532678950799961875567888635885568999999999999871841255212332103456 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSL 284 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~L 284 (523) -+|+++|.+|+|. +.. +.+--+.++-++++..|+||+|...|...+ T Consensus 104 -----------------~~p~ilVGNK~Dl-----------~~~---~~~~~~~~a~~~~~~~fetSAk~g~nV~e~ 149 (161) T cd04124 104 -----------------EIPCIVVANKIDL-----------DPS---VTQKKFNFAEKHNLPLYYVSAADGTNVVKL 149 (161) T ss_pred -----------------CCEEEEEECCCCC-----------CHH---HHHHHHHHHHHCCCCEEEEECCCCCCHHHH T ss_conf -----------------9379998237656-----------435---689999999965991999972689887899 No 87 >1z0j_A RAB-22, RAS-related protein RAB-22A; RAB GTPase, RAB22 GTPase, endosomal trafficking; HET: GTP; 1.32A {Mus musculus} SCOP: c.37.1.8 Probab=97.62 E-value=0.017 Score=38.67 Aligned_columns=154 Identities=22% Q ss_pred EEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHH Q ss_conf 47886477987321232331111245566312256567444433420223310006774551101678717887112320 Q Fun_An_XP_0013 48 NLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPL 127 (523) Q Consensus 48 nilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~L 127 (523) .|+|+|..+.||+|||..+.+..... .....- +..+....+...... .++.+|-. .|...+..+ T Consensus 8 kI~iiG~~~vGKSsLi~~l~~~~~~~----~~~~t~--------~~~~~~~~~~~~~~~---~~~~~~d~-~g~~~~~~~ 71 (170) T 1z0j_A 8 KVCLLGDTGVGKSSIMWRFVEDSFDP----NINPTI--------GASFMTKTVQYQNEL---HKFLIWDT-AGLERFRAL 71 (170) T ss_dssp EEEEECCTTSSHHHHHHHHHHSCCCT----TCCCCC--------SEEEEEEEEEETTEE---EEEEEEEE-CCSGGGGGG T ss_pred EEEEEECCCCCHHHHHHHHHCCCCCC----CCCCCC--------CHHHHHHCCCCCCEE---EEEEECCC-CCCCHHHHH T ss_conf 88998079987899999986481355----523200--------000111001001403---54431026-662012121 Q ss_pred HHHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 01105810120033433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 128 LKPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 128 Lk~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) .+..+..-.. ++++.|.+.+-.+-+ +..|+..++.....- T Consensus 72 ~~~~~~~~~~----~i~v~d~~~~~s~~~-~~~~~~~~~~~~~~~----------------------------------- 111 (170) T 1z0j_A 72 APMYYRGSAA----AIIVYDITKEETFST-LKNWVRELRQHGPPS----------------------------------- 111 (170) T ss_dssp THHHHTTCSE----EEEEEETTCHHHHHH-HHHHHHHHHHHSCTT----------------------------------- T ss_pred HHHHHCCCCE----EEEEEECCCCHHHHH-HHHHHHHHHCCCCCC----------------------------------- T ss_conf 0132036650----799974355113432-333432211037998----------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHH Q ss_conf 4532136888753267895079996187556788863588556899999999999987184125521233210345655 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIH 286 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh 286 (523) +|+++|++|+| |..++...+++ ++.++-++++..|.||++...+++.|.. T Consensus 112 ------------------~piilv~nK~D----l~~~~~~~~~~-------~~~~~~~~~~~~~e~Sa~~~~~i~elf~ 161 (170) T 1z0j_A 112 ------------------IVVAIAGNKCD----LTDVREVMERD-------AKDYADSIHAIFVETSAKNAININELFI 161 (170) T ss_dssp ------------------SEEEEEEECTT----CGGGCCSCHHH-------HHHHHHHTTCEEEECBTTTTBSHHHHHH T ss_pred ------------------CEEEEEECCCC----HHHHHHHHHHH-------HHHHHHHCCCEEEEEECCCCCCHHHHHH T ss_conf ------------------46999833430----01332013578-------8999995498599985268978889999 No 88 >d1ukvy_ c.37.1.8 (Y:) GTPase Ytp1 {Baker's yeast (Saccharomyces cerevisiae)} Probab=97.62 E-value=0.01 Score=40.12 Aligned_columns=152 Identities=17% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|..+.||+||+..+....... ++...- +..|.+..+...+.. .++.+|-. .|...+ T Consensus 9 I~iiG~~~vGKTSLi~~~~~~~~~~----~~~~t~--------~~~~~~~~~~~~~~~---~~i~i~D~-~g~e~~---- 68 (204) T d1ukvy_ 9 LLLIGNSGVGKSCLLLRFSDDTYTN----DYISTI--------GVDFKIKTVELDGKT---VKLQIWDT-AGQERF---- 68 (204) T ss_dssp EEEEESTTSSHHHHHHHHHHSCCCT----TCCCSS--------CCCEEEEEEEETTEE---EEEEEECC-TTTTTT---- T ss_pred EEEEECCCCCHHHHHHHHHCCCCCC----CCCCCE--------EEEEEEEEEEECCEE---EEEEEECC-CCCCHH---- T ss_conf 8898169977999999986481057----624521--------124668899888868---87443026-773012---- Q ss_pred HHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 110581012003-3433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 129 KPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 129 k~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) ..+.+..+.++ .+|+|.|.+.+.++-. +++|+.-++..... T Consensus 69 -~~~~~~~~~~ad~iilvfd~~d~~S~~~-~~~~~~~i~~~~~~------------------------------------ 110 (204) T d1ukvy_ 69 -RTITSSYYRGSHGIIIVYDVTDQESFNG-VKMWLQEIDRYATS------------------------------------ 110 (204) T ss_dssp -TCCCHHHHTTCSEEEEEEETTCHHHHHH-HHHHHHHHHHHSCT------------------------------------ T ss_pred -HHHHHHHHCCCCEEEEEEECCCHHHHHH-HHHHHHHHHHHHCC------------------------------------ T ss_conf -3456776147974799985166012335-68999998653102------------------------------------ Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHH Q ss_conf 4532136888753267895079996187556788863588556899999999999987184125521233210345655 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIH 286 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh 286 (523) .+|++||++|+| ++.++.-..+ -++.||..+|+..|-||.+...+.+.+.+ T Consensus 111 -----------------~~~iiivgnK~D----~~~~~~v~~~-------e~~~~~~~~~~~~~e~SAk~~~gi~e~f~ 161 (204) T d1ukvy_ 111 -----------------TVLKLLVGNKCD----LKDKRVVEYD-------VAKEFADANKMPFLETSALDSTNVEDAFL 161 (204) T ss_dssp -----------------TCEEEEEEECTT----CTTTCCSCHH-------HHHHHHHHTTCCEEECCTTTCTTHHHHHH T ss_pred -----------------CCEEEEEEECCC----CHHCCCCCHH-------HHHHHHHHCCCEEEEEECCCCCCHHHHHH T ss_conf -----------------410245541134----0010254189-------99999996198189995168988899999 No 89 >2gf0_A GTP-binding protein DI-RAS1; GDP/GTP binding, GTP hydrolysis, structural genomics, structural genomics consortium, SGC; HET: GDP; 1.90A {Homo sapiens} SCOP: c.37.1.8 Probab=97.62 E-value=0.0038 Score=42.86 Aligned_columns=156 Identities=14% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+|+|..+.||++|+..+-...... +... -.+..|..+..-+... -++.+|-. .|...+..+- T Consensus 11 I~viG~~~vGKSsli~~~~~~~~~~----~~~~----------t~~~~~~~~~~~~~~~--~~~~i~d~-~g~~~~~~~~ 73 (199) T 2gf0_A 11 VVVFGAGGVGKSSLVLRFVKGTFRD----TYIP----------TIEDTYRQVISCDKSV--CTLQITDT-TGSHQFPAMQ 73 (199) T ss_dssp EEEEECTTSSHHHHHHHHHHSCCCC----TTSC----------CCCEEEEEEEEETTEE--EEEEEEEC-CGGGSCHHHH T ss_pred EEEEECCCCCHHHHHHHHHCCCCCC----CCCC----------CEEEEEEEEEEECCCC--CEEEEEEC-CCCCHHHHHH T ss_conf 9997079987999999986284267----6343----------0222578998506622--20235421-2211002343 Q ss_pred HHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC Q ss_conf 11058101200334333000031368999999999999998506958889999999998622688767777767777664 Q Fun_An_XP_0013 129 KPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSSA 208 (523) Q Consensus 129 k~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s~ 208 (523) +..+.- --.++|+.|.+.+.++ +.+..|+.++.++-... T Consensus 74 ~~~~~~----~~~~iiv~d~~~~~S~-~~~~~~~~~~~~~~~~~------------------------------------ 112 (199) T 2gf0_A 74 RLSISK----GHAFILVFSVTSKQSL-EELGPIYKLIVQIKGSV------------------------------------ 112 (199) T ss_dssp HHHHHH----CSEEEEEEETTCHHHH-HTTHHHHHHHHHHHSCG------------------------------------ T ss_pred HHHCCC----CCEEEEEEECHHHHHH-HHHHHHHHHHHHHCCCC------------------------------------ T ss_conf 211022----2200011101023467-77665310003320234------------------------------------ Q ss_pred CCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHH Q ss_conf 53213688875326789507999618755678886358855689999999999998718412552123321034565532 Q Fun_An_XP_0013 209 GPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIHSS 288 (523) Q Consensus 209 ~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh~~ 288 (523) -++|+++|++|+| ..++.-..|+. +.||-.+|...|.+|.+...++..+.... T Consensus 113 ---------------~~~piilvgnK~D-----l~~~~v~~e~~-------~~~~~~~~~~~~e~Sa~~g~gi~~~f~~i 165 (199) T 2gf0_A 113 ---------------EDIPVMLVGNKCD-----ETQREVDTREA-------QAVAQEWKCAFMETSAKMNYNVKELFQEL 165 (199) T ss_dssp ---------------GGSCEEEEEECTT-----CSSCSSCHHHH-------HHHHHHHTCEEEECBTTTTBSHHHHHHHH T ss_pred ---------------CCCEEEEHHHHHH-----HHCCCCCHHHH-------HHHHHHCCCEEEEEECCCCCCHHHHHHHH T ss_conf ---------------7720220100110-----11026678899-------99999659708998616886778999999 Q ss_pred C Q ss_conf 2 Q Fun_An_XP_0013 289 L 289 (523) Q Consensus 289 l 289 (523) + T Consensus 166 ~ 166 (199) T 2gf0_A 166 L 166 (199) T ss_dssp H T ss_pred H T ss_conf 9 No 90 >cd04160 Arfrp1 Arfrp1 subfamily. Arfrp1 (Arf-related protein 1), formerly known as ARP, is a membrane-associated Arf family member that lacks the N-terminal myristoylation motif. Arfrp1 is mainly associated with the trans-Golgi compartment and the trans-Golgi network, where it regulates the targeting of Arl1 and the GRIP domain-containing proteins, golgin-97 and golgin-245, onto Golgi membranes. It is also involved in the anterograde transport of the vesicular stomatitis virus G protein from the Golgi to the plasma membrane, and in the retrograde transport of TGN38 and Shiga toxin from endosomes to the trans-Golgi network. Arfrp1 also inhibits Arf/Sec7-dependent activation of phospholipase D. Deletion of Arfrp1 in mice causes embryonic lethality at the gastrulation stage and apoptosis of mesodermal cells, indicating its importance in development. Probab=97.61 E-value=0.012 Score=39.73 Aligned_columns=162 Identities=22% Q ss_pred EEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHH Q ss_conf 47886477987321232331111245566312256567444433420223310006774551101678717887112320 Q Fun_An_XP_0013 48 NLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPL 127 (523) Q Consensus 48 nilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~L 127 (523) .||++|..+.|||+||..+.............+-.- .+|+.+..+.-.+ .++.+|=+ .|...|..+ T Consensus 1 ~IvliG~~~~GKTsll~rl~~~~~~~~~~~~~~~~~--------T~g~~~~~i~~~~-----~~l~iwD~-~Gqe~~~~~ 66 (167) T cd04160 1 SVLILGLDNAGKTTFLEQLKTLFSKYKGLPPSKITP--------TVGLNIGTIEVGN-----ARLKFWDL-GGQESLRSL 66 (167) T ss_pred CEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCEEE--------EEEEEEEEEEECC-----EEEEEEEC-CCCHHHHHH T ss_conf 978995189868999999852024456754440333--------5545898888878-----89999846-874046776 Q ss_pred HHHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 01105810120033433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 128 LKPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 128 Lk~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) -+.... .--.+|+|+|-+++ +++..+..++.+.+..-... T Consensus 67 ~~~y~~----~a~~ii~VvD~sd~----~~~~~~~~~l~~~l~~~~~~-------------------------------- 106 (167) T cd04160 67 WDKYYA----ECHAIIYVIDSTDR----ERFEESKSALEKVLRNEALE-------------------------------- 106 (167) T ss_pred HHHHCC----CCCEEEEEEECCCC----CCHHHHHHHHHHHHHCCCCC-------------------------------- T ss_conf 764157----98679999744875----35688999999997221558-------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHH Q ss_conf 4532136888753267895079996187556788863588556899999999999987184125521233210345655 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIH 286 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh 286 (523) ++|++|++.|+| .......|+.--+++-.-..+-+..-.+|.||++.-.+++..+. T Consensus 107 -----------------~~Pili~~NK~D------l~~~~~~eei~~~l~~~~~~~~~r~~~~~~~SA~tG~Gv~e~f~ 162 (167) T cd04160 107 -----------------GVPLLILANKQD------LPDALSVEEIKEVFQDKAEEIGRRDCLVLPVSALEGTGVREGIE 162 (167) T ss_pred -----------------CCEEEEEECCCC------CCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHH T ss_conf -----------------977999834879------53123788999999988998740891799985136888899999 No 91 >d1kao__ c.37.1.8 (-) Rap2a {Human (Homo sapiens)} Probab=97.61 E-value=0.0087 Score=40.54 Aligned_columns=157 Identities=15% Q ss_pred EEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHH Q ss_conf 47886477987321232331111245566312256567444433420223310006774551101678717887112320 Q Fun_An_XP_0013 48 NLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPL 127 (523) Q Consensus 48 nilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~L 127 (523) .|+++|...+||+||+..+....... ..+|....+.-...+++-.. ..+..|-. .|...+..+ T Consensus 5 ki~lvG~~~vGKTsLi~~l~~~~~~~---------~~~~t~~~~~~~~~~~~~~~-------~~~~i~d~-~g~~~~~~~ 67 (167) T d1kao__ 5 KVVVLGSGGVGKSALTVQFVTGTFIE---------KYDPTIEDFYRKEIEVDSSP-------SVLEILDT-AGTEQFASM 67 (167) T ss_dssp EEEEECCTTSSHHHHHHHHHHSCCCS---------CCCTTCCEEEEEEEEETTEE-------EEEEEEEC-CCTTCCHHH T ss_pred EEEEEECCCCCHHHHHHHHHCCCCCC---------CCCCCCEEEEEEEEEECCEE-------EEEEEEEE-CCCCHHHHH T ss_conf 89998179987899999986482167---------63653012689999873678-------99998730-274301233 Q ss_pred HHHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 01105810120033433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 128 LKPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 128 Lk~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) .+..+..- -.++++.|.+.|.++-. +..|..-+......- T Consensus 68 ~~~~~~~~----~~~i~v~d~~~~~s~~~-~~~~~~~~~~~~~~~----------------------------------- 107 (167) T d1kao__ 68 RDLYIKNG----QGFILVYSLVNQQSFQD-IKPMRDQIIRVKRYE----------------------------------- 107 (167) T ss_dssp HHHHHHHC----SEEEEEEETTCHHHHHH-HHHHHHHHHHHTTTS----------------------------------- T ss_pred HHHHHCCC----CEEEEEEECCCCCCCCH-HHHHHHHHHHHCCCC----------------------------------- T ss_conf 25430277----66999985043333211-347788988641799----------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHH Q ss_conf 45321368887532678950799961875567888635885568999999999999871841255212332103456553 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIHS 287 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh~ 287 (523) ++|++||.+|+| |+.......+ .++.++.++|+..|.||.+...+...|... T Consensus 108 -----------------~~piiivgnK~D----l~~~~~v~~~-------~~~~~~~~~~~~~~e~Sa~~g~gi~~lf~~ 159 (167) T d1kao__ 108 -----------------KVPVILVGNKVD----LESEREVSSS-------EGRALAEEWGCPFMETSAKSKTMVDELFAE 159 (167) T ss_dssp -----------------CCCEEEEEECGG----GGGGCCSCHH-------HHHHHHHHHTSCEEEECTTCHHHHHHHHHH T ss_pred -----------------CCEEEEEEECCC----CCCCCCCCHH-------HHHHHHHHCCCEEEEEECCCCCCHHHHHHH T ss_conf -----------------846999750335----4556667989-------999999964980899861689788899999 Q ss_pred HC Q ss_conf 22 Q Fun_An_XP_0013 288 SL 289 (523) Q Consensus 288 ~l 289 (523) .+ T Consensus 160 i~ 161 (167) T d1kao__ 160 IV 161 (167) T ss_dssp HH T ss_pred HH T ss_conf 99 No 92 >2nzj_A GTP-binding protein REM 1; GDP/GTP binding, GTP hydrolysis, RAD and GEM like GTP binding protein 1, structural genomics; HET: GDP; 2.50A {Homo sapiens} Probab=97.60 E-value=0.0075 Score=40.95 Aligned_columns=155 Identities=17% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+|+|....||++|+..+.+.......+.. +..+.-..|.-.+.+ -++.+|=.+.........+ T Consensus 7 i~ivG~~~vGKSsLi~~~~~~~~~~~~~t~-------------~~~~~~~~i~~~~~~---~~~~i~Dt~g~~~~~~~~~ 70 (175) T 2nzj_A 7 VVLLGDPGVGKTSLASLFAGKQERDLHEQL-------------GEDVYERTLTVDGED---TTLVVVDTWEAEKLDKSWS 70 (175) T ss_dssp EEEECCTTSSHHHHHHHHHCC-----CCCS-------------SSSEEEEEEEETTEE---EEEEEECCC-------CHH T ss_pred EEEEECCCCCHHHHHHHHHCCCCCCCCCCE-------------EEEEEEECCCCCCEE---EEEEEECCCCHHHHHHHHH T ss_conf 989827998799999998557246653760-------------443453003446536---7777621221013434433 Q ss_pred HHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 110581012003-3433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 129 KPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 129 k~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) ..+. ++++ .++++.|.+++.++ +.+.+|..-++.....- T Consensus 71 ~~~~----~~~~d~~ilv~d~~~~~s~-~~~~~~~~~~~~~~~~~----------------------------------- 110 (175) T 2nzj_A 71 QESC----LQGGSAYVIVYSIADRGSF-ESASELRIQLRRTHQAD----------------------------------- 110 (175) T ss_dssp HHHT----TTSCSEEEEEEETTCHHHH-HHHHHHHHHHHHC--------------------------------------- T ss_pred HHHH----HHHHHHHHHHHHCCCCCCC-HHHHHHHHHHHHHCCCC----------------------------------- T ss_conf 3565----4322454444311123430-03567778876312577----------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHH Q ss_conf 45321368887532678950799961875567888635885568999999999999871841255212332103456553 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIHS 287 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh~ 287 (523) ++|++||.+||| |+....-..++- +.||.+||+..|-||.+-..++..+... T Consensus 111 -----------------~~~iilvgnK~D----l~~~~~v~~~~~-------~~~~~~~~~~~~e~Sa~~~~~i~~~f~~ 162 (175) T 2nzj_A 111 -----------------HVPIILVGNKAD----LARCREVSVEEG-------RACAVVFDCKFIETSATLQHNVAELFEG 162 (175) T ss_dssp -----------------CCCEEEEEECTT----CTTTCCSCHHHH-------HHHHHHHTSEEEECBTTTTBSHHHHHHH T ss_pred -----------------CEEEEEEECCCC----HHHHHCCCHHHH-------HHHHHHCCCCEEEEECCCCCCHHHHHHH T ss_conf -----------------427999814766----112204417788-------8899974981899862588788899999 No 93 >cd04123 Rab21 Rab21 subfamily. The localization and function of Rab21 are not clearly defined, with conflicting data reported. Rab21 has been reported to localize in the ER in human intestinal epithelial cells, with partial colocalization with alpha-glucosidase, a late endosomal/lysosomal marker. More recently, Rab21 was shown to colocalize with and affect the morphology of early endosomes. In Dictyostelium, GTP-bound Rab21, together with two novel LIM domain proteins, LimF and ChLim, has been shown to regulate phagocytosis. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site Probab=97.57 E-value=0.0081 Score=40.75 Aligned_columns=151 Identities=12% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|..+.||++|+..+....-.. ++..-- +.+|....+.-++.. ..+.+|=. .|...+..+. T Consensus 3 i~~iGd~~vGKTsli~r~~~~~f~~----~~~~ti--------~~~~~~k~i~~~~~~---~~l~iwDt-~G~~~~~~~~ 66 (162) T cd04123 3 VVLLGEGRVGKTSLVLRYVENKFNE----KHESTT--------QASFFQKTVNIGGKR---IDLAIWDT-AGQERYHALG 66 (162) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCC----CCCCCC--------CCCCEEEEEECCCCE---EEEEEEEC-CCCHHHHHHH T ss_conf 8998269965899999986281177----645411--------244135533159938---99997307-8750235665 Q ss_pred HHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC Q ss_conf 11058101200334333000031368999999999999998506958889999999998622688767777767777664 Q Fun_An_XP_0013 129 KPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSSA 208 (523) Q Consensus 129 k~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s~ 208 (523) +..+. .-..++++-|.+.+.+|-. +++|+.-++++... T Consensus 67 ~~~~~----~a~~~ilvydit~~~Sf~~-i~~w~~~i~~~~~~------------------------------------- 104 (162) T cd04123 67 PIYYR----DADGAILVYDITDADSFQK-VKKWIKELKQMRGN------------------------------------- 104 (162) T ss_pred HHHHC----CCCEEEEEEECCCHHHHHH-HHHHHHHHHHHCCC------------------------------------- T ss_conf 76614----8986899942798778999-99999989973189------------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHH Q ss_conf 5321368887532678950799961875567888635885568999999999999871841255212332103456 Q Fun_An_XP_0013 209 GPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSL 284 (523) Q Consensus 209 ~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~L 284 (523) .+|+++|.+|+| |++++.-..++ .+.+|-++|+..|-||++...|...+ T Consensus 105 ----------------~~piilVGNK~D----l~~~r~V~~~~-------~~~~a~~~~~~~~E~Sak~~~nv~e~ 153 (162) T cd04123 105 ----------------NISLVIVGNKID----LERQRVVSKSE-------AEEYAKSVGAKHFETSAKTGKGIEEL 153 (162) T ss_pred ----------------CCEEEEEEEHHH----HHHHCCCCHHH-------HHHHHHHCCCCEEEEECCCCCCHHHH T ss_conf ----------------965999840023----12102547789-------99999964993899971589787899 No 94 >cd04125 RabA_like RabA-like subfamily. RabA was first identified in D. discoideum, where its expression levels were compared to other Rabs in growing and developing cells. The RabA mRNA levels were below the level of detection by Northern blot analysis, suggesting a very low level of expression. The function of RabA remains unknown. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site at the C-terminus, with sequence motifs CC, CXC, or CCX. Lipid binding is essential for membrane attachment, a key feature of most Rab proteins. Probab=97.56 E-value=0.0088 Score=40.52 Aligned_columns=150 Identities=15% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|..+.||++|+..+....... .+..-- |.+|..-.|.=.+.. ..+.+|=.+..+-+ T Consensus 3 IvviGd~~VGKTsli~r~~~~~f~~----~~~~Ti--------g~d~~~k~i~~~~~~---v~l~iwDtaGqe~~----- 62 (188) T cd04125 3 VVIIGDYGVGKSSLLKRFTEDEFSE----STKSTI--------GVDFKIKTVYIENKI---IKLQIWDTNGQERF----- 62 (188) T ss_pred EEEEECCCCCHHHHHHHHHCCCCCC----CCCCCE--------EEEEEEEEEEECCEE---EEEEEEECCCCCHH----- T ss_conf 8998269954899999876280177----646730--------212578899986849---99998756998202----- Q ss_pred HHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 110581012003-3433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 129 KPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 129 k~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) ..+.+..++++ .+||+-|.+.+.+| +.+++|+.-++++... T Consensus 63 -~~l~~~~~~~a~~~ilvyDit~~~Sf-~~i~~w~~~i~~~~~~------------------------------------ 104 (188) T cd04125 63 -RSLNNSYYRGAHGYLLVYDVTDQESF-ENLKFWINEINRYARE------------------------------------ 104 (188) T ss_pred -HHHHHHHHCCCCEEEEEEECCCHHHH-HHHHHHHHHHHHHCCC------------------------------------ T ss_conf -56768763089859999866997899-9999999999861699------------------------------------ Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHH Q ss_conf 45321368887532678950799961875567888635885568999999999999871841255212332103456 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSL 284 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~L 284 (523) .+|+++|++|+| |+.++.-..++ .+.||-++|+..|-||++...|...+ T Consensus 105 -----------------~~~~ilvgNK~D----L~~~r~V~~~~-------~~~~a~~~~~~~fEtSAktg~nV~e~ 153 (188) T cd04125 105 -----------------NVIKVIVANKSD----LVNNKVVDSNI-------AKSFCDSLNIPFFETSAKQSINVEEA 153 (188) T ss_pred -----------------CCEEEEEEECCC----CHHHCCCCHHH-------HHHHHHHCCCCEEEEECCCCCCHHHH T ss_conf -----------------968999851352----30123369999-------99999856992999962589888899 No 95 >cd04128 Spg1 Spg1p. Spg1p (septum-promoting GTPase) was first identified in the fission yeast S. pombe, where it regulates septum formation in the septation initiation network (SIN) through the cdc7 protein kinase. Spg1p is an essential gene that localizes to the spindle pole bodies. When GTP-bound, it binds cdc7 and causes it to translocate to spindle poles. Sid4p (septation initiation defective) is required for localization of Spg1p to the spindle pole body, and the ability of Spg1p to promote septum formation from any point in the cell cycle depends on Sid4p. Spg1p is negatively regulated by Byr4 and cdc16, which form a two-component GTPase activating protein (GAP) for Spg1p. The existence of a SIN-related pathway in plants has been proposed. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are Probab=97.56 E-value=0.014 Score=39.21 Aligned_columns=155 Identities=19% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|+.+.||++|+-......-.. .+.--- |+.|.-..+.=.+.. ..+.+|=. .|.-.|..+. T Consensus 3 ivliGd~~VGKTsLi~r~~~~~F~~----~y~~Ti--------G~~~~~k~i~v~~~~---v~l~iwDt-aGqE~f~~~~ 66 (182) T cd04128 3 IGLLGDAQIGKTSLMVKYVEGEFDE----DYIQTL--------GVNFMEKTISIRGTE---ITFSIWDL-GGQREFINML 66 (182) T ss_pred EEEEECCCCCHHHHHHHHHCCEECC----CCCCEE--------EEEEEEEEEEECCEE---EEEEEEEC-CCCCCCHHHH T ss_conf 8998169843888877764371277----635503--------446789899988968---99887316-8883101277 Q ss_pred HHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC Q ss_conf 11058101200334333000031368999999999999998506958889999999998622688767777767777664 Q Fun_An_XP_0013 129 KPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSSA 208 (523) Q Consensus 129 k~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s~ 208 (523) +....--. .++|+-|.+.+-+| +.+++|+..++.+ ... T Consensus 67 ~~y~~~a~----~~ilVfDit~~~Sf-~~i~~W~~~i~~~----~~~--------------------------------- 104 (182) T cd04128 67 PLVCNDAV----AILFMFDLTRKSTL-NSIKEWYRQARGF----NKT--------------------------------- 104 (182) T ss_pred HHHCCCCC----EEEEEEECCCHHHH-HHHHHHHHHHHHH----CCC--------------------------------- T ss_conf 86403777----68999865997899-9999999999862----799--------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHH Q ss_conf 5321368887532678950799961875567888635885568999999999999871841255212332103456 Q Fun_An_XP_0013 209 GPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSL 284 (523) Q Consensus 209 ~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~L 284 (523) .+|| +|-+|+|.+ .+...+.-+.+....+.+|-++|+.+|.||.|...|...+ T Consensus 105 ----------------~~~I-LVGNK~DL~------~~~~~~~~~~~~~~~~~~a~~~~~~~~etSAktg~nV~e~ 157 (182) T cd04128 105 ----------------AIPI-LVGTKYDLF------ADLPPEEQEEITKQARKYAKAMKAPLIFCSTSHSINVQKI 157 (182) T ss_pred ----------------CCEE-EEECCCCCC------CCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHH T ss_conf ----------------6089-983274310------0144245677889999999972995999972479887899 No 96 >1ksh_A ARF-like protein 2; small GTPase, small GTP-binding protein, ARF family; HET: CME GDP; 1.80A {Mus musculus} SCOP: c.37.1.8 Probab=97.56 E-value=0.0028 Score=43.71 Aligned_columns=155 Identities=16% Q ss_pred EEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHH Q ss_conf 47886477987321232331111245566312256567444433420223310006774551101678717887112320 Q Fun_An_XP_0013 48 NLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPL 127 (523) Q Consensus 48 nilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~L 127 (523) .|+++|..+.||+||+..+.+.+.....+.. +..+.-++..+ .++.+|-+ .|...+ T Consensus 20 kI~iiG~~~vGKTsLl~~l~~~~~~~~~~t~-------------~~~~~~i~~~~-------~~~~i~D~-~g~~~~--- 75 (186) T 1ksh_A 20 RLLMLGLDNAGKTTILKKFNGEDVDTISPTL-------------GFNIKTLEHRG-------FKLNIWDV-GGQKSL--- 75 (186) T ss_dssp EEEEECSTTSSHHHHHHHHTTCCCSSCCCCS-------------SEEEEEEEETT-------EEEEEEEE-CCSHHH--- T ss_pred EEEEEECCCCCHHHHHHHHHCCCCCEEEEEE-------------EEEEEEEECCC-------EEEEEEEC-CCCCCH--- T ss_conf 7999816998799999988378340343367-------------66887640587-------35787741-562300--- Q ss_pred HHHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC Q ss_conf 0110581012003-343330000313689999999999999985069588899999999986226887677777677776 Q Fun_An_XP_0013 128 LKPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTS 206 (523) Q Consensus 128 Lk~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~ 206 (523) ..+....++++ .++++.|.+++..+-+..+.|..+++....+ T Consensus 76 --~~~~~~~~~~~d~~i~v~d~~~~~~~~~~~~~~~~~~~~~~~~----------------------------------- 118 (186) T 1ksh_A 76 --RSYWRNYFESTDGLIWVVDSADRQRMQDCQRELQSLLVEERLA----------------------------------- 118 (186) T ss_dssp --HTTGGGGCTTCSEEEEEEETTCGGGHHHHHHHHHHHHTCGGGT----------------------------------- T ss_pred --HHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCC----------------------------------- T ss_conf --1212543123354303563013102688998753112222116----------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHH Q ss_conf 64532136888753267895079996187556788863588556899999999999987184125521233210345655 Q Fun_An_XP_0013 207 SAGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIH 286 (523) Q Consensus 207 s~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh 286 (523) ++|++||++|+|. .-....-+..++....++-.++...|.+|.+...++..++. T Consensus 119 ------------------~~piiiv~nK~Dl--------~~~~~~~~i~~~~~~~~~~~~~~~~~~~Sa~~g~gi~e~~~ 172 (186) T 1ksh_A 119 ------------------GATLLIFANKQDL--------PGALSCNAIQEALELDSIRSHHWRIQGCSAVTGEDLLPGID 172 (186) T ss_dssp ------------------TCEEEEEEECTTS--------TTCCCHHHHHHHTTGGGCCSSCEEEEECCTTTCTTHHHHHH T ss_pred ------------------CCCEEEEEECCCC--------CCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHH T ss_conf ------------------7634898622587--------43479889999999886411782699985267988899999 Q ss_pred HHC Q ss_conf 322 Q Fun_An_XP_0013 287 SSL 289 (523) Q Consensus 287 ~~l 289 (523) ..+ T Consensus 173 ~L~ 175 (186) T 1ksh_A 173 WLL 175 (186) T ss_dssp HHH T ss_pred HHH T ss_conf 999 No 97 >1zd9_A ADP-ribosylation factor-like 10B; transport protein, GDP-binding, membrane trafficking, structural genomics, structural genomics consortium, SGC; HET: GDP; 1.70A {Homo sapiens} SCOP: c.37.1.8 Probab=97.56 E-value=0.0021 Score=44.60 Aligned_columns=181 Identities=17% Q ss_pred HHHHHHHHHHCCCC-----CEEEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCC Q ss_conf 89888766404884-----2047886477987321232331111245566312256567444433420223310006774 Q Fun_An_XP_0013 32 SSMLDSVANGKRLP-----EKNLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHE 106 (523) Q Consensus 32 ssiL~~vss~~rlp-----sKnilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~e 106 (523) |+--.+-+++.-+| +-.|+++|..+.||+||+..|....... +... -+|+.+..+.-.+ T Consensus 3 ~~~~~~~~~s~~~p~g~~~~~kI~ivG~~~~GKTsLi~~l~~~~~~~----~~~~----------Ti~~~~~~i~~~~-- 66 (188) T 1zd9_A 3 SSHHHHHHSSGLVPRGSKEEMELTLVGLQYSGKTTFVNVIASGQFNE----DMIP----------TVGFNMRKITKGN-- 66 (188) T ss_dssp ----------------CCEEEEEEEECSTTSSHHHHHHHHHHSCCCC----SCCC----------CCSEEEEEEEETT-- T ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCCCC----CCEE----------EEECEEEECCCCE-- T ss_conf 53233333557788877760589998259987899999985680222----4101----------3402032035753-- Q ss_pred CCCCEEEEEEECCCCHHHHHHHHHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH Q ss_conf 55110167871788711232001105810120033433300003136899999999999999850695888999999999 Q Fun_An_XP_0013 107 DTLARVSAYLLSEPSLSFAPLLKPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTE 186 (523) Q Consensus 107 D~~aR~svyiL~d~d~~~~~LLk~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~ 186 (523) .++.+|=. .|...+..+.+..+.. -..++++.|.+++.+ ++.+..|+.-+.++...- T Consensus 67 ---~~~~i~D~-~G~~~~~~~~~~~~~~----~~~~ilv~d~~d~~s-~~~~~~~~~~i~~~~~~~-------------- 123 (188) T 1zd9_A 67 ---VTIKLWDI-GGQPRFRSMWERYCRG----VSAIVYMVDAADQEK-IEASKNELHNLLDKPQLQ-------------- 123 (188) T ss_dssp ---EEEEEEEE-CCSHHHHTTHHHHHTT----CSEEEEEEETTCGGG-HHHHHHHHHHHHTCGGGT-------------- T ss_pred ---EEEEEEEE-CCCCCCCCCCHHHHCC----CCCCCCCCCCCCCCC-HHHHHHHHHHHHHHHHCC-------------- T ss_conf ---79988630-2300012231012114----321010035532311-012456655431011117-------------- Q ss_pred HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH Q ss_conf 86226887677777677776645321368887532678950799961875567888635885568999999999999871 Q Fun_An_XP_0013 187 WRDRKRGMDSSSGGAQGFTSSAGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKH 266 (523) Q Consensus 187 ~~e~~~~~~~~~~~~~~~~~s~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqY 266 (523) ++|++||++|+|.......+ +++...-..++-.+ T Consensus 124 --------------------------------------~~piiiv~nK~Dl~~~~~~~--------~i~~~~~~~~~~~~ 157 (188) T 1zd9_A 124 --------------------------------------GIPVLVLGNKRDLPGALDEK--------ELIEKMNLSAIQDR 157 (188) T ss_dssp --------------------------------------TCCEEEEEECTTSTTCCCHH--------HHHHHTTGGGCCSS T ss_pred --------------------------------------CCEEEEEEECCCCCCCCCHH--------HHHHHHHHHHHHHC T ss_conf --------------------------------------83477522004654547887--------89999888887517 Q ss_pred CCEEEEECCCCCCCHHHHHHHHCCCCCCCCCCC Q ss_conf 841255212332103456553225322466755 Q Fun_An_XP_0013 267 GASLIYTTPFLANSLQSLIHSSLGIHSLLKRQS 299 (523) Q Consensus 267 GAsLiYTS~~~~~nl~~Llh~~lgih~ll~~~~ 299 (523) +...|.||.+...++..++... ++.+-.|.+ T Consensus 158 ~~~~~~~Sa~~g~gv~e~~~~l--i~~i~~~~~ 188 (188) T 1zd9_A 158 EICCYSISCKEKDNIDITLQWL--IQHSKSRRS 188 (188) T ss_dssp CEEEEECCTTTCTTHHHHHHHH--HHTCC---- T ss_pred CCEEEEEECCCCCCHHHHHHHH--HHHHHHCCC T ss_conf 9669998524787889999999--999985069 No 98 >cd04159 Arl10_like Arl10-like subfamily. Arl9/Arl10 was identified from a human cancer-derived EST dataset. No functional information about the subfamily is available at the current time, but crystal structures of human Arl10b and Arl10c have been solved. Probab=97.55 E-value=0.0035 Score=43.09 Aligned_columns=153 Identities=20% Q ss_pred EEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHH Q ss_conf 47886477987321232331111245566312256567444433420223310006774551101678717887112320 Q Fun_An_XP_0013 48 NLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPL 127 (523) Q Consensus 48 nilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~L 127 (523) +|+++|..+.|||+|+..+....... +... -+||.|..|...+ .++.+|=+ .|...|.++ T Consensus 1 ~IvivG~~~vGKTsl~~~~~~~~f~~----~~~~----------Tig~~~~~i~~~~-----~~l~iwDt-aGqe~~~~~ 60 (159) T cd04159 1 EITLVGLQNSGKTTLVNVIAGGQFSE----DTIP----------TVGFNMRKVTKGN-----VTLKVWDL-GGQPRFRSM 60 (159) T ss_pred CEEEEECCCCCHHHHHHHHHCCCCCC----CEEE----------EEEEEEEEEEECC-----EEEEEEEC-CCCHHHHHH T ss_conf 97899428986899999875494165----3230----------0002799988477-----89999855-873135788 Q ss_pred HHHCCCHHHHCCE-EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC Q ss_conf 0110581012003-343330000313689999999999999985069588899999999986226887677777677776 Q Fun_An_XP_0013 128 LKPLLTPQSIPET-LVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTS 206 (523) Q Consensus 128 Lk~al~~~sl~~T-LVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~ 206 (523) . +.-++++ .+|+|.|-|++ +++.....++++.+.....+ T Consensus 61 ~-----~~y~~~a~~ii~V~D~td~----~s~~~~~~~l~~ll~~~~~~------------------------------- 100 (159) T cd04159 61 W-----ERYCRGVNAIVYVVDAADR----TALEAAKNELHDLLEKPSLE------------------------------- 100 (159) T ss_pred H-----HHHHHCCCCEEEEEECCCH----HHHHHHHHHHHHHHHCCCCC------------------------------- T ss_conf 9-----8763104851799854886----67899999999875103779------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHH Q ss_conf 64532136888753267895079996187556788863588556899999999999987184125521233210345655 Q Fun_An_XP_0013 207 SAGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSLIH 286 (523) Q Consensus 207 s~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~Llh 286 (523) ++|+++|+.|+|.-+.+..+.--.+..++.+++. .-..|-||++...+++.++. T Consensus 101 ------------------~ipili~gNK~Dl~~~~~~~e~~~~~~~~~~~~~--------~~~~~~~SAktg~gI~e~f~ 154 (159) T cd04159 101 ------------------GIPLLVLGNKNDLPGALSVDELIEQMNLKSITDR--------EVSCYSISCKEKTNIDIVLD 154 (159) T ss_pred ------------------CCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCC--------CCEEEEEECCCCCCHHHHHH T ss_conf ------------------9579998124684212588899999989998518--------94589986147988899999 No 99 >cd04136 Rap_like Rap-like subfamily. The Rap subfamily consists of the Rap1, Rap2, and RSR1. Rap subfamily proteins perform different cellular functions, depending on the isoform and its subcellular localization. For example, in rat salivary gland, neutrophils, and platelets, Rap1 localizes to secretory granules and is believed to regulate exocytosis or the formation of secretory granules. Rap1 has also been shown to localize in the Golgi of rat fibroblasts, zymogen granules, plasma membrane, and microsomal membrane of the pancreatic acini, as well as in the endocytic compartment of skeletal muscle cells and fibroblasts. Rap1 localizes in the nucleus of human oropharyngeal squamous cell carcinomas (SCCs) and cell lines. Rap1 plays a role in phagocytosis by controlling the binding of adhesion receptors (typically integrins) to their ligands. In yeast, Rap1 has been implicated in multiple functions, including activation and silencing of transcription and maintenance of telomeres. Probab=97.55 E-value=0.0052 Score=41.97 Aligned_columns=151 Identities=15% Q ss_pred EEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHH Q ss_conf 78864779873212323311112455663122565674444334202233100067745511016787178871123200 Q Fun_An_XP_0013 49 LLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPLL 128 (523) Q Consensus 49 ilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~LL 128 (523) |+++|+.+-||++|+..+...+ ....-.|-+++.+--.. ..++....+.+|=. .|...|..+. T Consensus 4 iilvGd~~VGKTsli~r~~~~~--------f~~~~~~ti~~~~~k~i--------~v~~~~~~l~iwDt-aG~e~~~~l~ 66 (163) T cd04136 4 VVVLGSGGVGKSALTVQFVQGI--------FVEKYDPTIEDSYRKQI--------EVDGQQCMLEILDT-AGTEQFTAMR 66 (163) T ss_pred EEEEECCCCCHHHHHHHHHCCE--------ECCCCCCCCCCCEEEEE--------EECCEEEEEEEEEC-CCCHHHHHHH T ss_conf 8997079843899999886280--------06765651000126889--------88896899998847-9980356888 Q ss_pred HHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC Q ss_conf 11058101200334333000031368999999999999998506958889999999998622688767777767777664 Q Fun_An_XP_0013 129 KPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSSA 208 (523) Q Consensus 129 k~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s~ 208 (523) +..+.--.. ++|+-|.+.+.+| +.+.+|...+......- T Consensus 67 ~~~~~~a~~----~ilvfdvt~~~Sf-~~i~~~~~~i~~~~~~~------------------------------------ 105 (163) T cd04136 67 DLYIKNGQG----FVLVYSITSQSSF-NDLQDLREQILRVKDTE------------------------------------ 105 (163) T ss_pred HHHHCCCCE----EEEEEECCCHHHH-HHHHHHHHHHHHHCCCC------------------------------------ T ss_conf 875116882----8999756997888-99999999999740899------------------------------------ Q ss_pred CCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHH Q ss_conf 5321368887532678950799961875567888635885568999999999999871841255212332103456 Q Fun_An_XP_0013 209 GPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQFMRTLLLKHGASLIYTTPFLANSLQSL 284 (523) Q Consensus 209 ~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~lRt~cLqYGAsLiYTS~~~~~nl~~L 284 (523) .+|+++|.+|+| |+.++-...++ ...++-++|+..|.||++...|...+ T Consensus 106 ----------------~ip~ilVGNK~D----L~~~r~v~~~~-------~~~~a~~~~~~~~E~Sak~~~nv~e~ 154 (163) T cd04136 106 ----------------NVPMVLVGNKCD----LEDERVVSREE-------GQALARQWGCPFYETSAKSKINVDEV 154 (163) T ss_pred ----------------CCEEEEECCCCC----CCCCCCCCHHH-------HHHHHHHCCCCEEEEECCCCCCHHHH T ss_conf ----------------938999724467----64656379899-------99999966995999971479787899 No 100 >2rex_B RHO-related GTP-binding protein RHO6; complex, structural genomics consortium, SGC, GTPase, GNP, plexin, effector domain, alternative splicing; HET: GNP; 2.30A {Homo sapiens} Probab=97.55 E-value=0.0011 Score=46.33 Aligned_columns=164 Identities=20% Q ss_pred EEEEECCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHHHHHH Q ss_conf 47886477987321232331111245566312256567444433420223310006774551101678717887112320 Q Fun_An_XP_0013 48 NLLILGGTPESQREFLDTLAADSSDPSLSNDKRKGRVPPVANQFALGYTYQDVLDADHEDTLARVSAYLLSEPSLSFAPL 127 (523) Q Consensus 48 nilvLGg~~~~k~tll~~Ls~~~~~~~~~~d~~kGr~ppia~~~~LgY~Y~dV~D~D~eD~~aR~svyiL~d~d~~~~~L 127 (523) .|+|+|..+.||++|+..+.... ......|-+...|...+ ..++..-++.+|=. .|...+..+ T Consensus 12 Ki~vvG~~~vGKTsli~~~~~~~--------~~~~~~~t~~~~~~~~~--------~~~~~~~~l~iwD~-~g~~~~~~~ 74 (197) T 2rex_B 12 KLVLVGDVQCGKTAMLQVLAKDC--------YPETYVPTVFENYTACL--------ETEEQRVELSLWDT-SGSPYYDNV 74 (197) T ss_dssp EEEEECSTTSSHHHHHHHHHHSC--------CCCSCCCCSEEEEEEEE-----------CCCEEEEEEEE-CCSGGGTTT T ss_pred EEEEEECCCCCHHHHHHHHHCCC--------CCCCCCCEEEEEEEEEE--------EEECEEEEEEEECC-CCCCCCCCC T ss_conf 89998169987899999986175--------57653432777567752--------32021457764113-121122212 Q ss_pred HHHCCCHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC Q ss_conf 01105810120033433300003136899999999999999850695888999999999862268876777776777766 Q Fun_An_XP_0013 128 LKPLLTPQSIPETLVVILLDWSDPWTWIRRLREWVRLLRHVLISLDDETKIVMEENLTEWRDRKRGMDSSSGGAQGFTSS 207 (523) Q Consensus 128 Lk~al~~~sl~~TLVvIvlDwS~PWt~me~L~~W~~vLr~hi~sL~~e~~~~mee~~~~~~e~~~~~~~~~~~~~~~~~s 207 (523) .+..+. .-..|+|+.|.+++=++-.-+..|...++++.. T Consensus 75 ~~~~~~----~~~~~i~v~d~~~~~S~~~~~~~~~~~~~~~~~------------------------------------- 113 (197) T 2rex_B 75 RPLCYS----DSDAVLLCFDISRPETVDSALKKWRTEILDYCP------------------------------------- 113 (197) T ss_dssp GGGGGT----TCSEEEEEEETTCTTTC--CHHHHHHHHHHHCT------------------------------------- T ss_pred CCCCCC----CEEEEEEEECCCHHHHHHHHHHHHHHHHHHHCC------------------------------------- T ss_conf 300010----112357630456067899999887776776179------------------------------------- Q ss_pred CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHH-HHHHHHHHCCEEEE-ECCCCC-CCHHHH Q ss_conf 453213688875326789507999618755678886358855689999999-99999871841255-212332-103456 Q Fun_An_XP_0013 208 AGPVTIPLGPGEWDEGLGIPMCVVCQGADKIEKLEKDHGWHEEQFDFILQF-MRTLLLKHGASLIY-TTPFLA-NSLQSL 284 (523) Q Consensus 208 ~~~v~lPLg~g~lt~nLGiPi~VVctkaD~i~~LEKe~dykdE~fDfIqQ~-lRt~cLqYGAsLiY-TS~~~~-~nl~~L 284 (523) .+|+++|++|+|...-...-..+.++.---|..- .+++|-++|+..++ ||.+.. ++.+.+ T Consensus 114 -----------------~~~iilVgnK~DL~~~~~~~~~~~~~~~~~is~~e~~~~a~~~~~~~y~E~Sakt~~~~v~~~ 176 (197) T 2rex_B 114 -----------------STRVLLIGCKTDLRTDLSTLMELSHQKQAPISYEQGCAIAKQLGAEIYLEGSAFTSEKSIHSI 176 (197) T ss_dssp -----------------TSEEEEEEECGGGGGCHHHHHHHHHTTCCCCCHHHHHHHHHHTTCSCEEECBTTTBHHHHHHH T ss_pred -----------------CCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEEEECCCCHHHHHH T ss_conf -----------------947999504568632113556655542046788999999996599589987523466127999 Q ss_pred HH Q ss_conf 55 Q Fun_An_XP_0013 285 IH 286 (523) Q Consensus 285 lh 286 (523) .. T Consensus 177 f~ 178 (197) T 2rex_B 177 FR 178 (197) T ss_dssp HH T ss_pred HH T ss_conf 99 Done!