HumanPRENbase
Database of Prenylated Human
Proteins and their Orthologues
Protein CaaX Farnesylation, CaaX Geranylgeranylation and Rab Geranylgeranylation

CLUSTER parameter selection

REQUIRE one of the features for at least one member of listed clusters:
Status-KNOWN Status-LIKELY Status-NEW
EXCLUDE clusters with the following features for at least one member:
Status-OUT-OF-CONTEXT
Other features for cluster members are ALLOWED.
Minimum cluster-size: 1

SEQUENCE parameter selection

INCLUDE entries with the following features:
FT-substrate(s) GGT1-substrate(s) Viruses Mammalia Aves Amphibia Fishes Insecta Nematoda Fungi Plants Other-Eukaryota
EXCLUDE entries with the following features:
GGT2-substrate(s) Synthetic-constructs
Ranked by evOluation of cluster after selection

Querycode: Hcs2220ce111ct11111111111111cm1se220st00202222222221r3 (save for easy recovery of the identical query parameters)
 Clusters  Selected Sequences
General Information Stats Stats Enzyme Taxonomic Kingdom Taxonomic Detail Eukaryota
Status Rank ClustID Name Pren Total PC EvO Number PC EvO FT GGT1 GGT2 Viruses Synthetic Eukaryota Mammalia Birds Amphibia Fishes Insecta Nematoda Fungi Plants Other
+ 1 4557920
(5 isoinpas)		 CDC42 - cell division cycle 42 GTP-binding protein, 25kD 44 52 26.000 37.231 43
Explore		 25.333 35.558 43 43 0 0 0 43 4 1 1 2 3 5 23 0 4
+ 2 55670772
(5 isoinpas)		 RhoA - Rho-related GTP-binding protein 34 40 20.000 28.900 33
Explore		 19.333 27.225 33 33 0 0 0 33 4 1 1 2 2 1 18 0 4
+ 3 54697048
(5 isoinpas)		 RAP1B, member of RAS oncogene family 30 31 13.417 29.032 28
Explore		 12.250 25.290 28 28 0 0 0 28 4 1 0 4 3 1 9 0 6
+ 4 15826631
(6 isoinpas)		 RAC1 - RAS-related C3 botulinum toxin substrate 1 42 52 26.000 33.923 36
Explore		 22.667 24.923 36 36 0 0 0 36 3 0 1 2 1 1 11 13 4
+ 5 15718763
(5 isoinpas)		 K-Ras, Kirsten rat sarcoma-2 viral v-Ki-ras2 oncogene homolog 32 38 17.250 26.947 29
Explore		 16.500 22.132 29 29 0 2 0 27 6 1 2 8 1 2 3 0 4
+ 6 5730120
(3 isoinpas)		 SNARE protein Ykt6 28 41 13.500 19.122 24
Explore		 12.000 14.049 24 24 0 0 0 24 3 0 2 1 0 0 13 4 1
+ 7 42490908
(3 isoinpas)		 RHEB - Ras homolog enriched in brain 25 28 10.000 22.321 18
Explore		 7.500 11.571 18 18 0 0 0 18 4 1 1 0 0 0 11 0 1
+ 8 15126742
(2 isoinpas)		 Lamin B1 13 15 7.583 11.267 13
Explore		 7.583 11.267 13 13 0 0 0 13 3 1 2 1 1 2 0 0 3
* 9 7706567
(2 isoinpas)		 guanine nucleotide binding protein G protein, gamma 13 12 14 5.000 10.286 12
Explore		 5.000 10.286 12 12 0 0 0 12 4 1 2 2 3 0 0 0 0
+ 10 20147713
(2 isoinpas)		 RALA, Ras family small GTP binding protein 11 13 5.500 9.308 11
Explore		 5.500 9.308 11 11 0 0 0 11 2 1 1 2 3 2 0 0 0
* 11 4506405
(2 isoinpas)		 RALB - v-ral simian leukemia viral oncogene homolog B; v-ral simian leukemia viral oncogene homolog B 12 13 4.167 11.077 11
Explore		 3.750 9.308 11 11 0 0 0 11 5 1 1 2 0 0 0 0 2
* 12 32698769
(no isoinpas)		 guanine nucleotide binding protein G protein, gamma 7 9 9 2.917 9.000 9
Explore		 2.917 9.000 9 9 0 0 0 9 4 0 1 2 1 1 0 0 0
+ 13 4456614
(6 isoinpas)		 PALM - paralemmin 9 9 2.333 9.000 9
Explore		 2.333 9.000 9 9 0 0 0 9 5 2 1 1 0 0 0 0 0
? 14 6330169
(no isoinpas)		 DUF544, KIAA1164 protein 17 20 7.083 14.450 13
Explore		 5.417 8.450 13 13 0 0 0 13 3 1 0 0 0 1 7 0 1
+ 15 1839517
(3 isoinpas)		 RhoE - Rho-related GTP-binding protein 9 10 3.000 8.100 9
Explore		 3.000 8.100 9 9 0 0 0 9 5 1 2 1 0 0 0 0 0
+ 16 51036603
(2 isoinpas)		 G-protein gamma-12 subunit 8 8 2.667 8.000 8
Explore		 2.667 8.000 8 8 0 0 0 8 3 0 1 0 3 1 0 0 0
? 17 7243161
(3 isoinpas)		 DUF544 10 11 4.167 9.091 9
Explore		 3.750 7.364 9 9 0 0 0 9 5 0 1 0 0 1 1 1 0
? 18 55777304
(3 isoinpas)		 Ubiquitin-like 3 12 14 7.000 10.286 10
Explore		 5.833 7.143 10 10 0 0 0 10 3 1 1 1 2 0 1 1 0
? 19 42822891
(no isoinpas)		 Selenoprotein W-related 9 9 3.000 9.000 8
Explore		 2.667 7.111 8 8 0 0 0 8 3 1 0 2 2 0 0 0 0
+ 20 68950
(2 isoinpas)		 RAP2B, member RAS oncogene family 7 7 2.917 7.000 7
Explore		 2.917 7.000 7 7 0 0 0 7 2 0 1 2 0 1 0 0 1
+ 21 13623559
(2 isoinpas)		 2',3'-cyclic nucleotide 3' phosphodiesterase 10 12 2.250 8.333 9
Explore		 2.000 6.750 9 9 0 0 0 9 6 0 1 2 0 0 0 0 0
+ 22 7657514
(no isoinpas)		 Rho6/Rnd1 - Rho-related GTP-binding protein 7 8 1.750 6.125 7
Explore		 1.750 6.125 7 7 0 0 0 7 4 0 2 1 0 0 0 0 0
+ 23 4506339
(2 isoinpas)		 peroxisomal biogenesis factor 19 17 28 8.000 10.321 13
Explore		 6.000 6.036 13 13 0 0 0 13 6 0 1 1 0 2 2 1 0
* 24 38016957
(2 isoinpas)		 RhoF - Rho-related GTP-binding protein 6 6 2.000 6.000 6
Explore		 2.000 6.000 6 6 0 0 0 6 3 1 1 1 0 0 0 0 0
+ 25 21166359
(no isoinpas)		 G-protein-coupled receptor kinase 7 7 9 1.167 5.444 7
Explore		 1.167 5.444 7 7 0 0 0 7 4 0 0 3 0 0 0 0 0
? 26 3417289
(3 isoinpas)		 C16orf45 homolog 6 7 1.500 5.143 6
Explore		 1.500 5.143 6 6 0 0 0 6 4 1 0 1 0 0 0 0 0
+ 27 3406430
(4 isoinpas)		 hPRL-3 protein tyrosine phosphatase 6 7 1.500 5.143 6
Explore		 1.500 5.143 6 6 0 0 0 6 3 0 1 2 0 0 0 0 0
+ 28 16740917
(no isoinpas)		 G protein, gamma 10 5 5 1.250 5.000 5
Explore		 1.250 5.000 5 5 0 0 0 5 3 0 1 1 0 0 0 0 0
? 29 40788968
(3 isoinpas)		 KIAA0878 protein 5 5 0.833 5.000 5
Explore		 0.833 5.000 5 5 0 0 0 5 4 1 0 0 0 0 0 0 0
+ 30 21553323
(no isoinpas)		 Di-Ras1, small GTP-binding tumor suppressor 1, Rig 5 5 0.833 5.000 5
Explore		 0.833 5.000 5 5 0 0 0 5 3 0 0 2 0 0 0 0 0
+ 31 21748630
(2 isoinpas)		 protein phosphatase 1 regulatory subunit 16A 10 13 2.500 7.692 8
Explore		 2.000 4.923 8 8 0 0 0 8 5 0 0 1 2 0 0 0 0
+ 32 4506381
(2 isoinpas)		 RAC2 - RAS-related C3 botulinum toxin substrate 2 9 10 2.667 8.100 7
Explore		 2.000 4.900 7 7 0 0 0 7 4 1 1 1 0 0 0 0 0
? 33 6164721
(7 isoinpas)		 F-box protein Fbl2 12 31 5.000 4.645 12
Explore		 5.000 4.645 12 12 0 0 0 12 5 1 0 2 0 1 3 0 0
+ 34 37595069
(no isoinpas)		 N-Ras, neuroblastoma RAS viral oncogene homolog 13 14 3.000 12.071 8
Explore		 2.000 4.571 8 8 0 0 0 8 6 1 0 0 0 0 0 0 1
* 35 36036
(3 isoinpas)		 RhoG - Rho-related GTP-binding protein 6 8 2.000 4.500 6
Explore		 2.000 4.500 6 6 0 0 0 6 2 1 1 2 0 0 0 0 0
+ 36 39653934
(4 isoinpas)		 lamin A/progerin 12 28 4.167 5.143 11
Explore		 3.750 4.321 11 11 0 0 0 11 4 1 1 1 0 0 0 0 4
* 37 15277321
(no isoinpas)		 RAS-like, family 10, member B 5 6 1.250 4.167 5
Explore		 1.250 4.167 5 5 0 0 0 5 3 0 1 1 0 0 0 0 0
* 38 54695756
(no isoinpas)		 RAC3 - RAS-related C3 botulinum toxin substrate 3 5 6 1.333 4.167 5
Explore		 1.333 4.167 5 5 0 0 0 5 2 1 0 1 0 0 0 0 1
* 39 23503303
(no isoinpas)		 conserved serine-threonine kinase 7 12 1.750 4.083 7
Explore		 1.750 4.083 7 7 0 0 0 7 4 0 0 0 2 1 0 0 0
* 40 54696976
(3 isoinpas)		 M-Ras, muscle RAS oncogene homolog, R-Ras3 9 12 3.000 6.750 7
Explore		 2.333 4.083 7 7 0 0 0 7 4 1 1 1 0 0 0 0 0
+ 41 31795561
(no isoinpas)		 complexin 4, binds to SNAP receptor complexes 4 4 1.000 4.000 4
Explore		 1.000 4.000 4 4 0 0 0 4 2 0 1 1 0 0 0 0 0
* 42 5454030
(no isoinpas)		 RRP22, RAS-related on chromosome 22 4 4 0.333 4.000 4
Explore		 0.333 4.000 4 4 0 0 0 4 4 0 0 0 0 0 0 0 0
+ 43 30583721
(3 isoinpas)		 lamin B2 14 37 5.500 5.297 12
Explore		 5.000 3.892 12 12 0 0 0 12 1 1 2 2 1 0 0 0 5
+ 44 37718739
(3 isoinpas)		 RhoB - Rho-related GTP-binding protein 5 7 1.667 3.571 5
Explore		 1.667 3.571 5 5 0 0 0 5 2 1 1 0 0 0 1 0 0
+ 45 4678722
(3 isoinpas)		 CLICK-III/CaMKIgamma - Calcium/calmodulin-dependent protein kinase type 1G 6 11 1.500 3.273 6
Explore		 1.500 3.273 6 6 0 0 0 6 4 1 0 1 0 0 0 0 0
* 46 54695658
(no isoinpas)		 RhoN - Rho-related GTP-binding protein 4 5 0.667 3.200 4
Explore		 0.667 3.200 4 4 0 0 0 4 3 0 0 1 0 0 0 0 0
? 47 13775218
(no isoinpas)		 cysteine-motif similar to RING finger 4 5 0.667 3.200 4
Explore		 0.667 3.200 4 4 0 0 0 4 3 1 0 0 0 0 0 0 0
* 48 5454028
(no isoinpas)		 R-Ras, related RAS viral r-ras oncogene homolog 4 5 0.333 3.200 4
Explore		 0.333 3.200 4 4 0 0 0 4 4 0 0 0 0 0 0 0 0
+ 49 4505669
(4 isoinpas)		 phosphodiesterase 6B, cGMP-specific, rod, beta 7 8 1.167 6.125 5
Explore		 0.833 3.125 5 5 0 0 0 5 4 0 1 0 0 0 0 0 0
+ 50 23503098
(3 isoinpas)		 X-linked retinitis pigmentosa GTPase regulator 6 12 0.250 3.000 6
Explore		 0.250 3.000 6 6 0 0 0 6 6 0 0 0 0 0 0 0 0
+ 51 18676540
(3 isoinpas)		 complexin 3, binds to SNAP receptor complexes 3 3 0.500 3.000 3
Explore		 0.500 3.000 3 3 0 0 0 3 2 0 0 1 0 0 0 0 0
* 52 51474992
(no isoinpas)		 low complexity rich protein 3 3 0.250 3.000 3
Explore		 0.250 3.000 3 3 0 0 0 3 3 0 0 0 0 0 0 0 0
+ 53 4758450
(no isoinpas)		 G protein, gamma 4 3 3 0.500 3.000 3
Explore		 0.500 3.000 3 3 0 0 0 3 2 0 1 0 0 0 0 0 0
* 54 15147246
(no isoinpas)		 G protein, gamma 8 3 3 0.500 3.000 3
Explore		 0.500 3.000 3 3 0 0 0 3 2 0 0 1 0 0 0 0 0
+ 55 20147741
(no isoinpas)		 Ras family small GTP binding protein TC21 6 6 1.250 6.000 4
Explore		 1.000 2.667 4 4 0 0 0 4 1 0 0 0 1 0 2 0 0
+ 56 54695766
(no isoinpas)		 RhoC - Rho-related GTP-binding protein 7 10 1.750 4.900 5
Explore		 1.250 2.500 5 5 0 0 0 5 3 0 0 1 0 0 1 0 0
+ 57 21707244
(9 isoinpas)		 guanylate binding proteins 1/2/5 9 15 2.667 5.400 6
Explore		 2.000 2.400 6 6 0 0 0 6 3 1 1 1 0 0 0 0 0
? 58 55664133
(4 isoinpas)		 novel protein 3 4 0.250 2.250 3
Explore		 0.250 2.250 3 3 0 0 0 3 3 0 0 0 0 0 0 0 0
? 59 51468012
(2 isoinpas)		 PREDICTED: hypothetical protein XP_498436 2 2 0.167 2.000 2
Explore		 0.167 2.000 2 2 0 0 0 2 2 0 0 0 0 0 0 0 0
? 60 51471395
(no isoinpas)		 C-terminal variation of peptidyl-prolyl cis-trans isomerase A 2 2 0.167 2.000 2
Explore		 0.167 2.000 2 2 0 0 0 2 2 0 0 0 0 0 0 0 0
* 61 33150588
(2 isoinpas)		 RhoJ - Rho-related GTP-binding protein 6 6 0.500 6.000 3
Explore		 0.250 1.500 3 3 0 0 0 3 3 0 0 0 0 0 0 0 0
? 62 27734755
(no isoinpas)		 F-box and leucine-rich repeat protein 20 6 26 2.083 1.385 6
Explore		 2.083 1.385 6 6 0 0 0 6 2 0 1 1 1 1 0 0 0
* 63 1705960
(4 isoinpas)		 Cone cGMP-specific 3',5'-cyclic phosphodiesterase alpha'-subunit 6 8 1.250 4.500 3
Explore		 0.750 1.125 3 3 0 0 0 3 0 1 1 1 0 0 0 0 0
+ 64 4885425
(2 isoinpas)		 H-Ras, v-Ha-ras Harvey rat sarcoma viral oncogene homolog 21 24 5.000 18.375 5
Explore		 1.333 1.042 5 5 0 0 0 5 0 0 0 0 1 1 1 0 2
? 65 51467487
(no isoinpas)		 F-box protein 10 3 9 0.500 1.000 3
Explore		 0.500 1.000 3 3 0 0 0 3 2 0 0 1 0 0 0 0 0
? 66 37182292
(no isoinpas)		 WLPL514 1 1 0.083 1.000 1
Explore		 0.083 1.000 1 1 0 0 0 1 1 0 0 0 0 0 0 0 0
* 67 55859596
(4 isoinpas)		 PALM2, paralemmin 2, A kinase anchor protein 2 2 5 0.167 0.800 2
Explore		 0.167 0.800 2 2 0 0 0 2 2 0 0 0 0 0 0 0 0
? 68 4505235
(2 isoinpas)		 mannose-6-phosphate isomerase 7 86 1.750 0.570 7
Explore		 1.750 0.570 7 7 0 0 0 7 5 1 0 1 0 0 0 0 0
? 69 51467591
(no isoinpas)		 PREDICTED: hypothetical protein XP_499158 1 2 0.083 0.500 1
Explore		 0.083 0.500 1 1 0 0 0 1 1 0 0 0 0 0 0 0 0
* 70 31616611
(2 isoinpas)		 RAP2C, member RAS oncogene family 9 9 1.333 9.000 2
Explore		 0.333 0.444 2 2 0 0 0 2 0 0 0 0 1 1 0 0 0
? 71 8051621
(2 isoinpas)		 2',5'-oligoadenylate synthetase 1 isoform E18 2 10 0.167 0.400 2
Explore		 0.167 0.400 2 2 0 0 0 2 2 0 0 0 0 0 0 0 0
+ 72 10518344
(no isoinpas)		 RAP2A, member RAS oncogene family 10 10 0.750 10.000 2
Explore		 0.167 0.400 2 2 0 0 0 2 0 0 0 0 2 0 0 0 0
+ 73 21361097
(no isoinpas)		 guanine nucleotide binding protein G protein, gamma 10 2 11 0.167 0.364 2
Explore		 0.167 0.364 2 2 0 0 0 2 2 0 0 0 0 0 0 0 0
+ 74 4758448
(no isoinpas)		 G protein, gamma 11 2 3 0.167 1.333 1
Explore		 0.083 0.333 1 1 0 0 0 1 0 0 0 0 0 0 0 0 1
+ 75 7706359
(3 isoinpas)		 DEXRAS1, dexamethasone-induced RAS 1, RASD1 12 12 1.000 12.000 2
Explore		 0.167 0.333 2 2 0 0 0 2 0 0 0 0 2 0 0 0 0
* 76 55661671
(no isoinpas)		 RAB18 short isoform, member RAS oncogene family 2 3 0.167 1.333 1
Explore		 0.083 0.333 1 1 0 0 0 1 1 0 0 0 0 0 0 0 0
? 77 51458801
(no isoinpas)		 TPR containing protein 3 4 0.250 2.250 1
Explore		 0.083 0.250 1 1 0 0 0 1 1 0 0 0 0 0 0 0 0
? 78 21750201
(no isoinpas)		 similar to C-terminus of Cat eye syndrome critical region protein 2 involved in cytoskeletal organisation 1 4 0.083 0.250 1
Explore		 0.083 0.250 1 1 0 0 0 1 1 0 0 0 0 0 0 0 0
? 79 55665766
(2 isoinpas)		 heparanase 2, glycosyl hydrolase family 79 N-terminal domain 1 5 0.083 0.200 1
Explore		 0.083 0.200 1 1 0 0 0 1 1 0 0 0 0 0 0 0 0
? 80 51476045
(no isoinpas)		 weak similarity to carbonic anhydrase 1 5 0.083 0.200 1
Explore		 0.083 0.200 1 1 0 0 0 1 1 0 0 0 0 0 0 0 0
? 81 12314158
(3 isoinpas)		 DUF1339, possibly integral membrane protein 11 21 0.917 5.762 2
Explore		 0.167 0.190 2 2 0 0 0 2 0 0 0 0 0 2 0 0 0
? 82 40353014
(no isoinpas)		 Chondroitin N-acetylgalactosaminyltransferase 1 7 0.083 0.143 1
Explore		 0.083 0.143 1 1 0 0 0 1 1 0 0 0 0 0 0 0 0
+ 83 4585864
(2 isoinpas)		 phosphodiesterase 6A, alpha subunit 7 7 0.500 7.000 1
Explore		 0.083 0.143 1 1 0 0 0 1 0 0 1 0 0 0 0 0 0
+ 84 4506529
(no isoinpas)		 rhodopsin kinase 6 8 0.500 4.500 1
Explore		 0.083 0.125 1 1 0 0 0 1 0 1 0 0 0 0 0 0 0
+ 85 54633194
(3 isoinpas)		 protein phosphatase 1, regulatory inhibitor subunit 16B 7 8 0.500 6.125 1
Explore		 0.083 0.125 1 1 0 0 0 1 0 0 0 0 1 0 0 0 0
+ 86 1710024
(2 isoinpas)		 RAB28, member RAS oncogene family isoform 1 8 9 0.583 7.111 1
Explore		 0.083 0.111 1 1 0 0 0 1 0 0 0 0 0 0 0 0 1
? 87 15559717
(no isoinpas)		 Adaptin 1 9 0.083 0.111 1
Explore		 0.083 0.111 1 1 0 0 0 1 1 0 0 0 0 0 0 0 0
? 88 21956647
(4 isoinpas)		 ubiquitin specific protease 32 9 11 0.667 7.364 1
Explore		 0.083 0.091 1 1 0 0 0 1 0 0 0 0 1 0 0 0 0
+ 89 38524620
(no isoinpas)		 prickle-like 2 10 12 0.833 8.333 1
Explore		 0.083 0.083 1 1 0 0 0 1 0 0 0 0 0 0 0 0 1
? 90 458692
(3 isoinpas)		 WD repeat domain 42A 7 16 0.500 3.062 1
Explore		 0.083 0.062 1 1 0 0 0 1 0 0 0 0 0 0 1 0 0
* 91 6841496
(3 isoinpas)		 RAB23, member RAS oncogene family 12 16 1.000 9.000 1
Explore		 0.083 0.062 1 1 0 0 0 1 0 0 0 0 0 0 0 0 1
? 92 28178838
(2 isoinpas)		 isocitrate dehydrogenase 3 NAD+ gamma isoform b precursor 1 18 0.083 0.056 1
Explore		 0.083 0.056 1 1 0 0 0 1 1 0 0 0 0 0 0 0 0
? 93 23065557
(no isoinpas)		 glutathione S-transferase M4 isoform 2 1 18 0.083 0.056 1
Explore		 0.083 0.056 1 1 0 0 0 1 1 0 0 0 0 0 0 0 0

Your query selected 634 sequences in 93 clusters.