HumanPRENbase
Database of Prenylated Human
Proteins and their Orthologues
Protein CaaX Farnesylation, CaaX Geranylgeranylation and Rab Geranylgeranylation

CLUSTER parameter selection

REQUIRE one of the features for at least one member of listed clusters:
Status-KNOWN
EXCLUDE clusters with the following features for at least one member:
Status-LIKELY Status-NEW Status-OUT-OF-CONTEXT
Other features for cluster members are ALLOWED.
Minimum cluster-size: 1

SEQUENCE parameter selection

INCLUDE entries with the following features:
Viruses Mammalia Aves Amphibia Fishes Insecta Nematoda Fungi Plants Other-Eukaryota
EXCLUDE entries with the following features:
Synthetic-constructs
Ranked by evOluation of full cluster

Querycode: Hcs2000ce111ct11111111111111cm1se111st00202222222221r2 (save for easy recovery of the identical query parameters)
 Clusters  Selected Sequences
General Information Stats Stats Enzyme Taxonomic Kingdom Taxonomic Detail Eukaryota
Status Rank ClustID Name Pren Total PC EvO Number PC EvO FT GGT1 GGT2 Viruses Synthetic Eukaryota Mammalia Birds Amphibia Fishes Insecta Nematoda Fungi Plants Other
+ 1 13569962
(4 isoinpas)		 RAB1B, member RAS oncogene family 68 72 42.750 64.222 67
Explore		 42.000 62.347 11 1 67 0 0 67 5 1 2 1 5 2 19 17 15
+ 2 4105819
(3 isoinpas)		 RAB7, member RAS oncogene family 56 58 36.750 54.069 56
Explore		 36.750 54.069 0 0 56 0 0 56 6 1 1 2 3 1 16 14 12
+ 3 4557920
(5 isoinpas)		 CDC42 - cell division cycle 42 GTP-binding protein, 25kD 44 52 26.000 37.231 44
Explore		 26.000 37.231 44 43 0 0 0 44 4 1 1 2 3 5 24 0 4
+ 4 15826631
(6 isoinpas)		 RAC1 - RAS-related C3 botulinum toxin substrate 1 42 52 26.000 33.923 42
Explore		 26.000 33.923 40 38 0 0 0 42 3 0 1 2 2 1 13 14 6
+ 5 49168476
(5 isoinpas)		 RAB11B, member RAS oncogene family 37 41 22.000 33.390 37
Explore		 22.000 33.390 5 0 37 0 0 37 3 1 1 2 0 1 11 10 8
+ 6 54697048
(5 isoinpas)		 RAP1B, member of RAS oncogene family 30 31 15.333 29.032 30
Explore		 15.333 29.032 29 29 0 0 0 30 4 1 1 4 3 1 9 0 7
+ 7 55670772
(5 isoinpas)		 RhoA - Rho-related GTP-binding protein 34 40 20.000 28.900 34
Explore		 20.000 28.900 33 34 0 0 0 34 4 1 1 2 3 1 18 0 4
+ 8 54696264
(3 isoinpas)		 RAB6A, member RAS oncogene family 31 34 21.750 28.265 30
Explore		 21.000 26.471 0 0 30 0 0 30 5 1 2 1 3 2 7 3 6
+ 9 4506365
(2 isoinpas)		 RAB2, member RAS oncogene family 32 37 20.000 27.676 31
Explore		 19.333 25.973 1 0 31 0 0 31 5 1 0 1 4 2 2 8 8
+ 10 15718763
(5 isoinpas)		 K-Ras, Kirsten rat sarcoma-2 viral v-Ki-ras2 oncogene homolog 32 38 17.250 26.947 32
Explore		 17.250 26.947 32 29 0 2 0 30 6 1 3 8 1 2 4 0 5
+ 11 106189
(2 isoinpas)		 RAB5A, member RAS oncogene family 25 27 17.250 23.148 25
Explore		 17.250 23.148 0 0 25 0 0 25 5 1 2 2 1 1 3 5 5
+ 12 42490908
(3 isoinpas)		 RHEB - Ras homolog enriched in brain 25 28 16.000 22.321 25
Explore		 16.000 22.321 25 18 0 0 0 25 4 1 1 1 3 2 12 0 1
+ 13 5730120
(3 isoinpas)		 SNARE protein Ykt6 28 41 13.500 19.122 28
Explore		 13.500 19.122 28 24 0 0 0 28 3 0 2 1 0 0 14 4 4
+ 14 4885425
(2 isoinpas)		 H-Ras, v-Ha-ras Harvey rat sarcoma viral oncogene homolog 21 24 11.250 18.375 21
Explore		 11.250 18.375 20 6 0 5 0 16 5 1 1 1 1 1 2 0 4
+ 15 7706563
(no isoinpas)		 RAB8B, member RAS oncogene family 18 20 9.917 16.200 18
Explore		 9.917 16.200 7 7 18 0 0 18 3 0 1 1 0 2 8 1 2
+ 16 21327708
(no isoinpas)		 nucleosome assembly protein 1-like 1 25 41 11.500 15.244 25
Explore		 11.500 15.244 25 0 0 0 0 25 3 1 2 1 0 0 11 7 0
+ 17 33695095
(2 isoinpas)		 RAB10, member RAS oncogene family 15 15 7.583 15.000 15
Explore		 7.583 15.000 0 0 15 0 0 15 4 1 1 2 2 2 0 0 3
+ 18 37595069
(no isoinpas)		 N-Ras, neuroblastoma RAS viral oncogene homolog 13 14 6.000 12.071 13
Explore		 6.000 12.071 13 8 0 0 0 13 6 1 1 1 0 0 3 0 1
+ 19 7706359
(3 isoinpas)		 DEXRAS1, dexamethasone-induced RAS 1, RASD1 12 12 6.000 12.000 12
Explore		 6.000 12.000 12 2 0 0 0 12 4 1 1 2 3 1 0 0 0
+ 20 15126742
(2 isoinpas)		 Lamin B1 13 15 7.583 11.267 13
Explore		 7.583 11.267 13 13 0 0 0 13 3 1 2 1 1 2 0 0 3
+ 21 19923260
(3 isoinpas)		 RAB4A, member RAS oncogene family 11 11 3.750 11.000 11
Explore		 3.750 11.000 0 0 11 0 0 11 5 1 0 2 2 0 0 0 1
+ 22 4506339
(2 isoinpas)		 peroxisomal biogenesis factor 19 17 28 9.333 10.321 17
Explore		 9.333 10.321 17 13 0 0 0 17 6 0 1 1 1 2 5 1 0
+ 23 48146269
(5 isoinpas)		 RAB27A, member RAS oncogene family 11 12 4.583 10.083 11
Explore		 4.583 10.083 0 0 11 0 0 11 4 0 2 1 3 1 0 0 0
+ 24 10518344
(no isoinpas)		 RAP2A, member RAS oncogene family 10 10 3.750 10.000 9
Explore		 3.750 8.100 9 2 0 0 0 9 4 0 1 1 2 0 0 0 1
+ 25 20147713
(2 isoinpas)		 RALA, Ras family small GTP binding protein 11 13 5.500 9.308 11
Explore		 5.500 9.308 11 11 0 0 0 11 2 1 1 2 3 2 0 0 0
+ 26 4456614
(6 isoinpas)		 PALM - paralemmin 9 9 2.333 9.000 9
Explore		 2.333 9.000 9 9 0 0 0 9 5 2 1 1 0 0 0 0 0
+ 27 7689363
(2 isoinpas)		 RAB3A, member RAS oncogene family 9 9 2.667 9.000 8
Explore		 2.333 7.111 0 0 8 0 0 8 3 0 1 2 2 0 0 0 0
+ 28 23308519
(3 isoinpas)		 prickle-like 1 9 9 3.750 9.000 9
Explore		 3.750 9.000 9 0 0 0 0 9 4 1 1 2 0 1 0 0 0
+ 29 4505783
(2 isoinpas)		 phosphorylase kinase, beta 13 19 4.583 8.895 13
Explore		 4.583 8.895 13 0 0 0 0 13 6 1 0 1 3 2 0 0 0
+ 30 13623559
(2 isoinpas)		 2',3'-cyclic nucleotide 3' phosphodiesterase 10 12 2.250 8.333 10
Explore		 2.250 8.333 10 9 0 0 0 10 6 0 2 2 0 0 0 0 0
+ 31 38524620
(no isoinpas)		 prickle-like 2 10 12 4.167 8.333 10
Explore		 4.167 8.333 10 1 0 0 0 10 4 0 0 2 2 1 0 0 1
+ 32 28200377
(3 isoinpas)		 DnaJA2 - DnaJ/Hsp40 homolog, subfamily A, member 2 14 24 8.167 8.167 14
Explore		 8.167 8.167 13 1 0 0 0 14 3 1 2 1 0 2 0 1 4
+ 33 4506381
(2 isoinpas)		 RAC2 - RAS-related C3 botulinum toxin substrate 2 9 10 3.333 8.100 9
Explore		 3.333 8.100 9 7 0 0 0 9 4 1 1 2 0 0 0 1 0
+ 34 1839517
(3 isoinpas)		 RhoE - Rho-related GTP-binding protein 9 10 3.000 8.100 9
Explore		 3.000 8.100 9 9 0 0 0 9 5 1 2 1 0 0 0 0 0
+ 35 51036603
(2 isoinpas)		 G-protein gamma-12 subunit 8 8 2.667 8.000 8
Explore		 2.667 8.000 8 8 0 0 0 8 3 0 1 0 3 1 0 0 0
+ 36 21748630
(2 isoinpas)		 protein phosphatase 1 regulatory subunit 16A 10 13 3.333 7.692 10
Explore		 3.333 7.692 10 8 0 0 0 10 5 0 0 1 2 2 0 0 0
+ 37 55665085
(2 isoinpas)		 BRO1/Rhophilin-like domain 9 11 3.000 7.364 9
Explore		 3.000 7.364 9 0 0 0 0 9 5 1 0 2 0 1 0 0 0
+ 38 1710024
(2 isoinpas)		 RAB28, member RAS oncogene family isoform 1 8 9 2.333 7.111 8
Explore		 2.333 7.111 8 1 0 0 0 8 5 1 0 1 0 0 0 0 1
+ 39 4585864
(2 isoinpas)		 phosphodiesterase 6A, alpha subunit 7 7 1.500 7.000 7
Explore		 1.500 7.000 7 1 0 0 0 7 5 0 1 1 0 0 0 0 0
+ 40 68950
(2 isoinpas)		 RAP2B, member RAS oncogene family 7 7 2.917 7.000 7
Explore		 2.917 7.000 7 7 0 0 0 7 2 0 1 2 0 1 0 0 1
+ 41 4092830
(2 isoinpas)		 DEXRAS2, RASD2, Rhes 7 7 2.333 7.000 7
Explore		 2.333 7.000 7 0 0 0 0 7 4 1 1 0 1 0 0 0 0
+ 42 4505669
(4 isoinpas)		 phosphodiesterase 6B, cGMP-specific, rod, beta 7 8 1.750 6.125 7
Explore		 1.750 6.125 7 5 0 0 0 7 5 0 1 1 0 0 0 0 0
+ 43 54633194
(3 isoinpas)		 protein phosphatase 1, regulatory inhibitor subunit 16B 7 8 1.500 6.125 7
Explore		 1.500 6.125 7 1 0 0 0 7 5 1 0 0 1 0 0 0 0
+ 44 2695592
(2 isoinpas)		 photoreceptor transducin gamma subunit T1 7 8 1.750 6.125 7
Explore		 1.750 6.125 7 0 0 0 0 7 4 0 1 2 0 0 0 0 0
+ 45 7657514
(no isoinpas)		 Rho6/Rnd1 - Rho-related GTP-binding protein 7 8 1.750 6.125 7
Explore		 1.750 6.125 7 7 0 0 0 7 4 0 2 1 0 0 0 0 0
+ 46 20147741
(no isoinpas)		 Ras family small GTP binding protein TC21 6 6 1.250 6.000 6
Explore		 1.250 6.000 6 4 0 0 0 6 1 0 0 0 2 0 3 0 0
+ 47 21166359
(no isoinpas)		 G-protein-coupled receptor kinase 7 7 9 1.167 5.444 7
Explore		 1.167 5.444 7 7 0 0 0 7 4 0 0 3 0 0 0 0 0
+ 48 21707244
(9 isoinpas)		 guanylate binding proteins 1/2/5 9 15 2.667 5.400 9
Explore		 2.667 5.400 8 7 0 0 0 9 6 1 1 1 0 0 0 0 0
+ 49 30583721
(3 isoinpas)		 lamin B2 14 37 5.500 5.297 14
Explore		 5.500 5.297 14 12 0 0 0 14 3 1 2 2 1 0 0 0 5
+ 50 3406430
(4 isoinpas)		 hPRL-3 protein tyrosine phosphatase 6 7 1.500 5.143 6
Explore		 1.500 5.143 6 6 0 0 0 6 3 0 1 2 0 0 0 0 0
+ 51 39653934
(4 isoinpas)		 lamin A/progerin 12 28 4.167 5.143 12
Explore		 4.167 5.143 12 11 0 0 0 12 4 1 1 2 0 0 0 0 4
+ 52 16740917
(no isoinpas)		 G protein, gamma 10 5 5 1.250 5.000 5
Explore		 1.250 5.000 5 5 0 0 0 5 3 0 1 1 0 0 0 0 0
+ 53 4758994
(2 isoinpas)		 RAB28, member RAS oncogene family isoform 2 5 5 1.250 5.000 5
Explore		 1.250 5.000 5 0 0 0 0 5 2 0 0 0 1 2 0 0 0
+ 54 21553323
(no isoinpas)		 Di-Ras1, small GTP-binding tumor suppressor 1, Rig 5 5 0.833 5.000 5
Explore		 0.833 5.000 5 5 0 0 0 5 3 0 0 2 0 0 0 0 0
+ 55 14589849
(no isoinpas)		 G protein, gamma 2, transducing activity 5 5 0.833 5.000 5
Explore		 0.833 5.000 5 0 0 0 0 5 4 0 0 1 0 0 0 0 0
+ 56 51460469
(6 isoinpas)		 RhoQ - Rho-related GTP-binding protein, TC10 5 5 1.250 5.000 5
Explore		 1.250 5.000 5 0 0 0 0 5 2 1 0 2 0 0 0 0 0
+ 57 54695766
(no isoinpas)		 RhoC - Rho-related GTP-binding protein 7 10 2.333 4.900 7
Explore		 2.333 4.900 5 7 0 0 0 7 3 1 0 1 0 0 2 0 0
+ 58 49257311
(3 isoinpas)		 RAB13, member RAS oncogene family 7 10 1.750 4.900 6
Explore		 1.500 3.600 5 1 6 0 0 6 4 0 0 1 0 0 0 0 1
+ 59 4506529
(no isoinpas)		 rhodopsin kinase 6 8 1.500 4.500 6
Explore		 1.500 4.500 6 1 0 0 0 6 4 1 0 1 0 0 0 0 0
+ 60 31795561
(no isoinpas)		 complexin 4, binds to SNAP receptor complexes 4 4 1.000 4.000 4
Explore		 1.000 4.000 4 4 0 0 0 4 2 0 1 1 0 0 0 0 0
+ 61 4507271
(2 isoinpas)		 LKB1 - serine/threonine protein kinase 11 7 13 2.333 3.769 7
Explore		 2.333 3.769 7 0 0 0 0 7 4 0 1 1 0 0 0 0 1
+ 62 37718739
(3 isoinpas)		 RhoB - Rho-related GTP-binding protein 5 7 1.667 3.571 5
Explore		 1.667 3.571 5 5 0 0 0 5 2 1 1 0 0 0 1 0 0
+ 63 4678722
(3 isoinpas)		 CLICK-III/CaMKIgamma - Calcium/calmodulin-dependent protein kinase type 1G 6 11 1.500 3.273 6
Explore		 1.500 3.273 6 6 0 0 0 6 4 1 0 1 0 0 0 0 0
+ 64 4506263
(no isoinpas)		 prostaglandin I2 prostacyclin receptor IP 4 5 0.250 3.200 4
Explore		 0.250 3.200 4 0 0 0 0 4 4 0 0 0 0 0 0 0 0
+ 65 18676540
(3 isoinpas)		 complexin 3, binds to SNAP receptor complexes 3 3 0.500 3.000 3
Explore		 0.500 3.000 3 3 0 0 0 3 2 0 0 1 0 0 0 0 0
+ 66 23503098
(3 isoinpas)		 X-linked retinitis pigmentosa GTPase regulator 6 12 0.250 3.000 6
Explore		 0.250 3.000 6 6 0 0 0 6 6 0 0 0 0 0 0 0 0
+ 67 4758450
(no isoinpas)		 G protein, gamma 4 3 3 0.500 3.000 3
Explore		 0.500 3.000 3 3 0 0 0 3 2 0 1 0 0 0 0 0 0
+ 68 627477
(4 isoinpas)		 INPP5A - inositol-polyphosphate 5-phosphatase EC 3.1.3. 5 15 1.250 1.667 5
Explore		 1.250 1.667 5 0 0 0 0 5 3 1 1 0 0 0 0 0 0
+ 69 1246236
(3 isoinpas)		 PTP-IV1b, protein tyrosine phosphatase 3 6 0.333 1.500 3
Explore		 0.333 1.500 3 0 0 0 0 3 2 0 1 0 0 0 0 0 0
+ 70 55770834
(4 isoinpas)		 centromere protein F 350/400kD 4 11 0.667 1.455 4
Explore		 0.667 1.455 4 0 0 0 0 4 3 1 0 0 0 0 0 0 0
+ 71 4758448
(no isoinpas)		 G protein, gamma 11 2 3 0.333 1.333 2
Explore		 0.333 1.333 2 1 0 0 0 2 1 0 0 0 0 0 0 0 1
+ 72 4502781
(2 isoinpas)		 centromere protein E 3 16 0.500 0.562 3
Explore		 0.500 0.562 3 0 0 0 0 3 2 0 1 0 0 0 0 0 0
+ 73 21361097
(no isoinpas)		 guanine nucleotide binding protein G protein, gamma 10 2 11 0.167 0.364 2
Explore		 0.167 0.364 2 2 0 0 0 2 2 0 0 0 0 0 0 0 0
+ 74 38606970
(4 isoinpas)		 phospholipase A2, group IVC cytosolic, calcium-independent 1 6 0.083 0.167 1
Explore		 0.083 0.167 1 0 0 0 0 1 1 0 0 0 0 0 0 0 0

Your query selected 988 sequences in 74 clusters.